Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HMSD	284293	broad.mit.edu	37	18	61627535	61627535	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:61627535C>T	ENST00000408945.3	+	4	568	c.366C>T	c.(364-366)ttC>ttT	p.F122F	HMSD_ENST00000481726.1_Intron	NM_001123366.1	NP_001116838.1	A8MTL9	HMSD_HUMAN	histocompatibility (minor) serpin domain containing	122						extracellular region	serine-type endopeptidase inhibitor activity	p.F122F(1)		kidney(1)|large_intestine(2)|lung(2)|stomach(1)	6						TATTCTATTTCGATAATATTT	0.299000													7	28					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21628966	21628966	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:21628966C>T	ENST00000328843.6	+	12	2145	c.2114C>T	c.(2113-2115)cCc>cTc	p.P705L	DNAH11_ENST00000409508.3_Missense_Mutation_p.P705L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	705	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTGAATCAACCCTTGGTTAAA	0.318000									Kartagener syndrome				27	58					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134825406	134825406	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:134825406T>C	ENST00000398015.3	+	4	1292	c.922T>C	c.(922-924)Tac>Cac	p.Y308H	EPHB1_ENST00000488154.1_3'UTR|EPHB1_ENST00000493838.1_5'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	308	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GACCGGTTATTACCGAGCGGA	0.587000													28	40					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57358297	57358297	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:57358297G>A	ENST00000518770.1	-	3	369	c.216C>T	c.(214-216)ccC>ccT	p.P72P	PENK_ENST00000523051.1_Intron|PENK_ENST00000314922.3_Intron|PENK_ENST00000451791.2_Intron			P01210	PENK_HUMAN	proenkephalin	131					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCCGCGCGGTGGGCCGGAGGC	0.667000													23	37					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990388	63990388	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:63990388G>A	ENST00000370657.4	-	4	1101	c.1068C>T	c.(1066-1068)agC>agT	p.S356S	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	356					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	CCATCAGGCAGCTGAGCGCAG	0.498000													72	48					0	0	1	0	0
SRD5A2	6716	broad.mit.edu	37	2	31754392	31754392	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:31754392G>A	ENST00000405650.1	-	0	848				AL133247.2_ENST00000435713.1_RNA			P31213	S5A2_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)						androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity					Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GTGGTGAAAAGCTCGCAGCCC	0.463000													21	33					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242271053	242271053	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:242271053C>T	ENST00000442594.2	-	9	1392	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	PLD5_ENST00000536534.1_Missense_Mutation_p.E387K|PLD5_ENST00000427495.1_Missense_Mutation_p.E325K	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	387						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GGATCAGTTTCCTTCCAGAAG	0.383000													70	197					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111025282	111025282	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:111025282A>T	ENST00000262839.2	-	8	2899	c.1981T>A	c.(1981-1983)Ttc>Atc	p.F661I		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	661					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ATGATGTTGAAAGGAGGTGGC	0.478000													97	26					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73585784	73585784	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:73585784C>T	ENST00000339362.5	+	27	4243	c.3796C>T	c.(3796-3798)Cac>Tac	p.H1266Y	NEO1_ENST00000261908.6_Missense_Mutation_p.H1266Y|NEO1_ENST00000560262.1_Intron|NEO1_ENST00000558964.1_Missense_Mutation_p.H1255Y			Q92859	NEO1_HUMAN	neogenin 1	1266					axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						CCATCATTTCCACTCCAGCAG	0.522000													72	138					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52940709	52940709	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:52940709G>A	ENST00000371544.3	-	13	2784	c.2522C>T	c.(2521-2523)tCg>tTg	p.S841L	ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000257177.4_Missense_Mutation_p.S841L	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	841					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TGGGTCAGGCGACTTAGACAA	0.398000													46	92					0	0	1	0	0
ARL14	80117	broad.mit.edu	37	3	160395381	160395381	+	Missense_Mutation	SNP	G	G	A	rs35634980	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:160395381G>A	ENST00000320767.2	+	1	434	c.247G>A	c.(247-249)Gat>Aat	p.D83N		NM_025047.2	NP_079323.1	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	83			D -> N (in dbSNP:rs35634980).		small GTPase mediated signal transduction	intracellular	GTP binding			lung(6)	6			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			TGAGAACACCGATGGGCTGGT	0.433000													32	54					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21033871	21033871	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:21033871C>T	ENST00000381545.3	+	12	1633	c.1414C>T	c.(1414-1416)Cca>Tca	p.P472S	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P472S|LST3_ENST00000540229.1_Missense_Mutation_p.P472S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P472S|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	472	Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TCAGTGGGAACCAGTCTGTGG	0.373000													61	111					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175067695	175067695	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:175067695C>T	ENST00000239462.4	+	9	2196	c.2083C>T	c.(2083-2085)Cag>Tag	p.Q695*		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	695	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GAAGGGGGACCAGGAGAGCAA	0.592000													35	113					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012930	29012930	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:29012930G>A	ENST00000377175.1	-	1	87	c.23C>T	c.(22-24)tCt>tTt	p.S8F		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						ACCATGTAAAGAACTATAATT	0.403000													31	88					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165173261	165173261	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:165173261G>A	ENST00000342310.3	-	9	1387	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	LMX1A_ENST00000294816.2_Silent_p.F335F|LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000367893.4_Silent_p.F335F	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	335						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CCAGGTCATGGAAAAGGGGCT	0.507000													44	108					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4445773	4445773	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:4445773G>A	ENST00000254718.4	-	22	3379	c.3073C>T	c.(3073-3075)Cgg>Tgg	p.R1025W	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.R1025W			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	1025					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						TGACGGGGCCGCACCGGGCCC	0.617000													5	146					0	0	1	0	0
KLHDC2	23588	broad.mit.edu	37	14	50244939	50244939	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:50244939G>C	ENST00000298307.5	+	5	1372	c.511G>C	c.(511-513)Gta>Cta	p.V171L	KLHDC2_ENST00000557247.1_Missense_Mutation_p.V171L|KLHDC2_ENST00000554589.1_Missense_Mutation_p.V171L|KLHDC2_ENST00000553538.1_3'UTR	NM_014315.2	NP_055130.1	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	171						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(31;0.000959)|Breast(41;0.0117)					TGAAGATAAAGTATTGGGAAC	0.308000													5	130					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216274397	216274397	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:216274397C>T	ENST00000354785.4	-	15	2557	c.2188G>A	c.(2188-2190)Gaa>Aaa	p.E730K	FN1_ENST00000421182.1_Missense_Mutation_p.E730K|FN1_ENST00000359671.1_Missense_Mutation_p.E730K|FN1_ENST00000357009.2_Missense_Mutation_p.E730K|FN1_ENST00000356005.4_Missense_Mutation_p.E730K|FN1_ENST00000443816.1_Missense_Mutation_p.E730K|FN1_ENST00000346544.3_Missense_Mutation_p.E730K|FN1_ENST00000345488.5_Missense_Mutation_p.E730K|FN1_ENST00000336916.4_Missense_Mutation_p.E730K|FN1_ENST00000323926.6_Missense_Mutation_p.E730K|FN1_ENST00000357867.4_Missense_Mutation_p.E730K|FN1_ENST00000446046.1_Missense_Mutation_p.E730K|FN1_ENST00000432072.2_Missense_Mutation_p.E730K			P02751	FINC_HUMAN	fibronectin 1	730	Fibronectin type-III 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTGTGATTTCGGTCACAGAT	0.542000													18	40					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72843566	72843566	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:72843566T>C	ENST00000293190.5	-	9	2028	c.1882A>G	c.(1882-1884)Atg>Gtg	p.M628V	GRIN2C_ENST00000347612.4_Missense_Mutation_p.M628V	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	628					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	ACCAGAACCATGATCTTGCTG	0.577000													60	83					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681259	55681259	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:55681259G>A	ENST00000344514.1	-	1	799	c.800C>T	c.(799-801)tCt>tTt	p.S267F		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TTGATCTAGAGAATAGGAAGA	0.438000													39	60					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224758	248224758	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:248224758C>T	ENST00000359959.3	+	1	775	c.775C>T	c.(775-777)Cta>Tta	p.L259L	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTACACTTATCTACGTCCAAG	0.493000													7	277					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599500	136599500	+	Silent	SNP	G	G	A	rs137966151		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:136599500G>A	ENST00000531224.1	-	4	771	c.519C>T	c.(517-519)ccC>ccT	p.P173P	BCLAF1_ENST00000527759.1_Silent_p.P171P|BCLAF1_ENST00000530767.1_Silent_p.P173P|BCLAF1_ENST00000527536.1_Silent_p.P173P|BCLAF1_ENST00000392348.2_Silent_p.P171P|BCLAF1_ENST00000353331.4_Silent_p.P171P	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	173					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCTCTTCTTGGGGTTCCCCTT	0.408000													72	209					0	0	1	0	0
TDGF1	6997	broad.mit.edu	37	3	46620608	46620608	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:46620608C>T	ENST00000296145.5	+	2	792	c.59C>T	c.(58-60)tCt>tTt	p.S20F	LRRC2_ENST00000296144.3_Intron|TDGF1_ENST00000542931.1_Missense_Mutation_p.S4F	NM_003212.3	NP_003203.1	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	20					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity			cervix(2)|endometrium(1)|kidney(1)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		ATGGCCATTTCTAAAGTCTTT	0.393000													64	98					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7329715	7329715	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:7329715C>T	ENST00000333870.3	+	3	479	c.405C>T	c.(403-405)cgC>cgT	p.R135R	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Intron	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	135	Arg-rich.					integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				gccgttgtcgccgtcgctgct	0.592000													40	76					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646362	57646362	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:57646362C>T	ENST00000269834.1	-	5	1728	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCAGAACATCCATAAGGTTT	0.408000													68	124					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153578164	153578164	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:153578164G>A	ENST00000422373.1	-	45	7629	c.7381C>T	c.(7381-7383)Ccc>Tcc	p.P2461S	FLNA_ENST00000344736.4_Missense_Mutation_p.P2429S|FLNA_ENST00000498491.1_5'UTR|FLNA_ENST00000360319.4_Missense_Mutation_p.P2461S|FLNA_ENST00000369856.3_Missense_Mutation_p.P602S|FLNA_ENST00000369850.3_Missense_Mutation_p.P2469S	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2469					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCTTGGAGGGGCCGTCAATG	0.612000											OREG0003592	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	26	10					0	0	1	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987148	7987148	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:7987148G>A	ENST00000221573.6	+	4	652	c.601G>A	c.(601-603)Gac>Aac	p.D201N	SNAPC2_ENST00000597584.1_5'UTR	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	201					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						CACTGAAGAAGACTTTGCTGT	0.592000													62	111					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85967974	85967974	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:85967974C>T	ENST00000372117.3	+	11	1111	c.1008C>T	c.(1006-1008)acC>acT	p.T336T	CDHR1_ENST00000332904.3_Silent_p.T336T|CDHR1_ENST00000440770.2_Silent_p.T95T	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	336	Cadherin 3.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						CCCAGGCCACCGTCCCAGTCA	0.582000													33	49					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140453	3140453	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:3140453C>T	ENST00000252463.2	-	5	904	c.817G>A	c.(817-819)Gaa>Aaa	p.E273K	ZSCAN10_ENST00000538082.2_Missense_Mutation_p.E191K|ZSCAN10_ENST00000575108.1_5'UTR	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	273					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						TCCAAAATTTCACTGCTGCCA	0.647000													101	163					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143792629	143792629	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:143792629G>A	ENST00000408949.2	+	1	489	c.429G>A	c.(427-429)ctG>ctA	p.L143L		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					GCACTGTCCTGGCCTCAACTT	0.448000													79	109					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144943558	144943558	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:144943558G>A	ENST00000525985.1	-	2	3935	c.3864C>T	c.(3862-3864)ttC>ttT	p.F1288F				P58107	EPIPL_HUMAN	epiplakin 1	1288						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTCAACAAGGAAGCCAGATG	0.667000													44	104					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113599432	113599432	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:113599432C>T	ENST00000297405.5	-	23	3992	c.3748G>A	c.(3748-3750)Gga>Aga	p.G1250R	CSMD3_ENST00000343508.3_Missense_Mutation_p.G1210R|CSMD3_ENST00000455883.2_Missense_Mutation_p.G1146R|CSMD3_ENST00000352409.3_Missense_Mutation_p.G1250R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1250	CUB 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGCAAAATTCCTTCATTATTC	0.348000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			44	130					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73012771	73012771	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:73012771C>T	ENST00000261180.4	+	13	2383	c.2287C>T	c.(2287-2289)Cct>Tct	p.P763S		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	763					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AGCTCTTTATCCTCTAGATAA	0.363000													59	74					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459813	66459813	+	RNA	SNP	G	G	A	rs10752517	by1000genomes	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:66459813G>A	ENST00000424345.1	+	0	73																											tccaggatttgtccccagtgc	0.343000													3	18					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995048	140995048	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:140995048G>A	ENST00000285879.4	+	4	2144	c.1858G>A	c.(1858-1860)Gaa>Aaa	p.E620K	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	620							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGGGGGAGGAATTCCAGTC	0.562000										HNSCC(15;0.026)			238	79					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121341742	121341742	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:121341742C>T	ENST00000338040.4	+	3	1880	c.1466C>T	c.(1465-1467)cCc>cTc	p.P489L		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	489					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding	p.P489H(1)		NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GATGAGTTCCCCCTGCACTTC	0.502000													12	29					0	0	1	0	0
MIR329-2	574409	broad.mit.edu	37	14	101493486	101493486	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:101493486G>A	ENST00000385029.1	+	0	50					NR_029968.1																						TATTGAGGACGAAACACACCT	0.458000													63	104					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40940389	40940389	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:40940389C>T	ENST00000246914.5	+	10	2025	c.2004C>T	c.(2002-2004)ctC>ctT	p.L668L	WNK4_ENST00000587705.1_3'UTR	NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	668					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GGAGGAATCTCCGGCGCAGAC	0.567000													26	65					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42466932	42466932	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:42466932G>A	ENST00000381668.5	-	26	2717	c.2486C>T	c.(2485-2487)tCc>tTc	p.S829F	ATP8A1_ENST00000264449.10_Missense_Mutation_p.S814F	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	829					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GTAGTCAGAGGAATTAGCTGC	0.443000													31	37					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58740832	58740832	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:58740832C>T	ENST00000305921.3	+	6	1969	c.1737C>T	c.(1735-1737)acC>acT	p.T579T		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	579					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TTAAACTCACCATGCGACGCA	0.448000											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	39	67					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28737419	28737419	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:28737419C>T	ENST00000257197.3	-	3	527	c.266G>A	c.(265-267)aGg>aAg	p.R89K	DSC1_ENST00000257198.5_Missense_Mutation_p.R89K|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	89					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AAAACTTTTCCTTTCAGAAGA	0.433000													33	52					0	0	1	0	0
MRPL11	65003	broad.mit.edu	37	11	66204361	66204361	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:66204361G>A	ENST00000329819.4	-	5	572	c.493C>T	c.(493-495)Cta>Tta	p.L165L	MRPL11_ENST00000524576.1_Intron|MRPL11_ENST00000430466.2_Intron|MRPL11_ENST00000310999.7_Intron	NM_170739.2	NP_733935.1	Q9Y3B7	RM11_HUMAN	mitochondrial ribosomal protein L11	0					translation		structural constituent of ribosome			endometrium(3)|lung(2)|ovary(1)|prostate(1)	7						CCATTTCTTAGAACATTTGCA	0.468000													39	63					0	0	1	0	0
HNRNPUL2	221092	broad.mit.edu	37	11	62490138	62490138	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:62490138C>T	ENST00000301785.5	-	6	1222	c.1030G>A	c.(1030-1032)Gaa>Aaa	p.E344K	RP11-831H9.16_ENST00000403734.2_Missense_Mutation_p.E344K	NM_001079559.2	NP_001073027.1	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 2	344	B30.2/SPRY.				cell killing	nucleus	ATP binding|nucleic acid binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TGTCCATTTTCTGCCTTGAGT	0.428000													47	74					0	0	1	0	0
TGFB3	7043	broad.mit.edu	37	14	76429781	76429781	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:76429781C>T	ENST00000238682.3	-	5	1101	c.804G>A	c.(802-804)aaG>aaA	p.K268K	TGFB3_ENST00000556285.1_Silent_p.K268K	NM_003239.2	NP_003230.1	P10600	TGFB3_HUMAN	transforming growth factor, beta 3	268					cell growth|cell-cell junction organization|detection of hypoxia|face morphogenesis|in utero embryonic development|induction of apoptosis|lung alveolus development|mammary gland development|menstrual cycle phase|negative regulation of cell proliferation|negative regulation of DNA replication|negative regulation of macrophage cytokine production|negative regulation of neuron apoptosis|odontogenesis|ossification involved in bone remodeling|palate development|platelet activation|platelet degranulation|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of collagen biosynthetic process|positive regulation of DNA replication|positive regulation of epithelial to mesenchymal transition|positive regulation of filopodium assembly|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|response to progesterone stimulus|salivary gland morphogenesis|transforming growth factor beta receptor signaling pathway	extracellular matrix|platelet alpha granule lumen	growth factor activity|identical protein binding|transforming growth factor beta binding|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11				BRCA - Breast invasive adenocarcinoma(234;0.0169)		CCTTCTGCTTCTTGAGGCGCC	0.572000													52	94					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54431397	54431397	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:54431397A>G	ENST00000566473.2	+	5	600	c.600A>G	c.(598-600)gaA>gaG	p.E200E	ANKFN1_ENST00000318698.2_Silent_p.E200E			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	200										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GGGCCCGAGAAAGTCCACACT	0.473000													9	29					0	0	1	0	0
PRL	5617	broad.mit.edu	37	6	22287760	22287760	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:22287760C>T	ENST00000306482.1	-	5	1073	c.555G>A	c.(553-555)caG>caA	p.Q185Q	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	185					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					CATCAGCCATCTGCAGGGATG	0.423000													28	84					0	0	1	0	0
F7	2155	broad.mit.edu	37	13	113770101	113770101	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:113770101C>T	ENST00000375581.3	+	6	593	c.558C>T	c.(556-558)tcC>tcT	p.S186S	F7_ENST00000541084.1_Silent_p.S117S|F7_ENST00000346342.3_Silent_p.S164S	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	186	EGF-like 2.		S -> F (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	ACGGGGTGTCCTGCACACCCA	0.602000													29	41					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468796	56468796	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:56468796C>T	ENST00000288221.6	-	2	495	c.240G>A	c.(238-240)atG>atA	p.M80I		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	80						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TTCCCAGAGTCATAGTGCCCT	0.507000													89	113					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212488718	212488718	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:212488718G>A	ENST00000342788.4	-	18	2441	c.2131C>T	c.(2131-2133)Cgt>Tgt	p.R711C	ERBB4_ENST00000402597.1_Missense_Mutation_p.R701C|ERBB4_ENST00000436443.1_Missense_Mutation_p.R711C	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	711					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.R711C(1)		NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTCAAAATACGAAGTTGAGCT	0.423000										TSP Lung(8;0.080)			28	46					0	0	1	0	0
PCYOX1	51449	broad.mit.edu	37	2	70502244	70502244	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:70502244G>A	ENST00000433351.2	+	4	676	c.648G>A	c.(646-648)atG>atA	p.M216I	PCYOX1_ENST00000505044.2_Missense_Mutation_p.M139I|PCYOX1_ENST00000264441.5_Missense_Mutation_p.M216I|PCYOX1_ENST00000545138.1_Missense_Mutation_p.M138I	NM_016297.3	NP_057381.3	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1	216					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)	15						TCAATGAAATGATTGCTCCTG	0.448000													70	134					0	0	1	0	0
INPP4B	8821	broad.mit.edu	37	4	143081585	143081585	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:143081585G>A	ENST00000513000.1	-	18	1922	c.1489C>T	c.(1489-1491)Ccc>Tcc	p.P497S	INPP4B_ENST00000308502.4_Missense_Mutation_p.P497S|INPP4B_ENST00000262992.4_Missense_Mutation_p.P497S|INPP4B_ENST00000509777.1_Missense_Mutation_p.P497S|INPP4B_ENST00000508116.1_Missense_Mutation_p.P497S	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	497					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TGGTCTTGGGGACTGCTCTCC	0.507000													57	86					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903093	5903093	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:5903093G>A	ENST00000378961.4	+	4	507	c.303G>A	c.(301-303)agG>agA	p.R101R		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	101						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CCTCCAGCAGGGGAGAGGCAG	0.552000													22	39					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198267481	198267481	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:198267481T>A	ENST00000335508.5	-	14	1967	c.1876A>T	c.(1876-1878)Aac>Tac	p.N626Y		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	626					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding	p.N626Y(2)|p.N626D(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GCTGTTGTGTTACGGACATAC	0.438000			Mis		myelodysplastic syndrome								26	65					0	0	1	0	0
DFNB59	494513	broad.mit.edu	37	2	179323240	179323240	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:179323240C>T	ENST00000409117.3	+	5	909	c.553C>T	c.(553-555)Cac>Tac	p.H185Y	DFNB59_ENST00000605419.1_3'UTR|DFNB59_ENST00000375129.4_Missense_Mutation_p.H185Y	NM_001042702.3	NP_001036167.1	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	185					sensory perception of sound					breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			AATATAGTTTCACTTTATGGA	0.318000													30	69					0	0	1	0	0
CD300LG	146894	broad.mit.edu	37	17	41926251	41926251	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:41926251C>T	ENST00000317310.4	+	2	410	c.369C>T	c.(367-369)ttC>ttT	p.F123F	CD300LG_ENST00000377203.4_Silent_p.F123F|CD300LG_ENST00000293396.8_Silent_p.F123F|CD300LG_ENST00000588884.1_Silent_p.F123F|CD300LG_ENST00000586233.1_Silent_p.F123F|CD300LG_ENST00000539718.1_Silent_p.F123F	NM_145273.3	NP_660316.2	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g	123						apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity			central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|skin(4)	19		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCTCTCTGTTCGTCTTTCCAG	0.557000													28	52					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107866985	107866985	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:107866985G>A	ENST00000370067.1	+	3	955	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370074.4_Missense_Mutation_p.E110K|NTNG1_ENST00000370065.1_Missense_Mutation_p.E110K|NTNG1_ENST00000542803.1_Missense_Mutation_p.E110K|NTNG1_ENST00000370072.3_Missense_Mutation_p.E110K|NTNG1_ENST00000370061.3_Missense_Mutation_p.E110K|NTNG1_ENST00000370070.2_Missense_Mutation_p.E110K|NTNG1_ENST00000370066.1_Missense_Mutation_p.E110K|NTNG1_ENST00000370073.2_Missense_Mutation_p.E110K|NTNG1_ENST00000370068.1_Missense_Mutation_p.E110K|NTNG1_ENST00000370071.2_Missense_Mutation_p.E110K			Q9Y2I2	NTNG1_HUMAN	netrin G1	110	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GTTTGATTTTGAAGGAAGACA	0.478000													105	183					0	0	1	0	0
PPP1CA	5499	broad.mit.edu	37	11	67166016	67166016	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:67166016G>A	ENST00000376745.4	-	7	1131	c.983C>T	c.(982-984)gCc>gTc	p.A328V	PPP1CA_ENST00000312989.7_Missense_Mutation_p.A339V|PPP1CA_ENST00000358239.4_Missense_Mutation_p.A284V|PPP1CA_ENST00000532446.1_5'UTR	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	328					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			CTATTTCTTGGCTTTGGCGGA	0.607000													18	41					0	0	1	0	0
COLQ	8292	broad.mit.edu	37	3	15495392	15495392	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:15495392C>T	ENST00000383788.5	-	16	1367	c.1242G>A	c.(1240-1242)gtG>gtA	p.V414V	COLQ_ENST00000383781.4_Silent_p.V404V|COLQ_ENST00000383785.2_3'UTR|COLQ_ENST00000603808.1_Silent_p.V415V|COLQ_ENST00000435459.2_Silent_p.V404V|COLQ_ENST00000383786.5_Silent_p.V380V|COLQ_ENST00000383787.2_Silent_p.V405V	NM_005677.3	NP_005668.2	Q9Y215	COLQ_HUMAN	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	414					acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft				endometrium(2)|large_intestine(4)|lung(10)|skin(3)	19						CACAGTCCTCCACACCCTCAT	0.587000													8	23					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128452344	128452344	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:128452344C>T	ENST00000297788.4	+	13	2886	c.2519C>T	c.(2518-2520)cCt>cTt	p.P840L	CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000464832.1_Intron|CCDC136_ENST00000487361.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	840						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GACGAGGAACCTGCTGAGCCT	0.522000													9	22					0	0	1	0	0
CBX2	84733	broad.mit.edu	37	17	77758698	77758698	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:77758698T>G	ENST00000310942.4	+	5	1560	c.1456T>G	c.(1456-1458)Tcc>Gcc	p.S486A		NM_005189.2	NP_005180.1	Q14781	CBX2_HUMAN	chromobox homolog 2	486					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCCGTCAGTGTCCGTTCAGAC	0.627000													26	45					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087225	47087225	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:47087225G>A	ENST00000374312.1	+	3	861	c.442G>A	c.(442-444)Ggc>Agc	p.G148S	NPY4R_ENST00000395716.1_Missense_Mutation_p.G148S	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CAACCCAACAGGCTGGAAGCC	0.592000													60	220					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189586498	189586498	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:189586498G>A	ENST00000264731.3	+	8	1211	c.1122G>A	c.(1120-1122)acG>acA	p.T374T	TP63_ENST00000392463.2_Silent_p.T280T|TP63_ENST00000392461.3_Silent_p.T280T|TP63_ENST00000437221.1_Silent_p.T280T|TP63_ENST00000440651.2_Intron|TP63_ENST00000392460.3_Silent_p.T374T|TP63_ENST00000456148.1_Intron|TP63_ENST00000354600.5_Silent_p.T280T|TP63_ENST00000320472.5_Silent_p.T374T|TP63_ENST00000418709.2_Silent_p.T374T|TP63_ENST00000382063.4_Silent_p.T289T|TP63_ENST00000449992.1_Silent_p.T195T	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	374	Interaction with HIPK2.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GTGATGGTACGAAGCGCCGTA	0.498000										HNSCC(45;0.13)			59	115					0	0	1	0	0
SOHLH1	402381	broad.mit.edu	37	9	138586222	138586222	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:138586222G>A	ENST00000298466.5	-	7	1017	c.957C>T	c.(955-957)ggC>ggT	p.G319G	SOHLH1_ENST00000425225.1_Intron	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	319					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		TGAACCCAGGGCCCCACTCAC	0.637000													21	39					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69796373	69796373	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:69796373C>T	ENST00000251566.4	-	5	1225	c.1195G>A	c.(1195-1197)Gat>Aat	p.D399N	UGT2A3_ENST00000420231.2_Missense_Mutation_p.D110N	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	399						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCTATGTTATCAAGCTGATCA	0.413000													64	102					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223062	44223062	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:44223062C>T	ENST00000244314.5	+	2	551	c.352C>T	c.(352-354)Cca>Tca	p.P118S		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	118						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				AGCCGGCTCTCCAGGCTGCCC	0.652000													21	25					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538746	55538746	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:55538746C>T	ENST00000220676.1	+	4	2452	c.2304C>T	c.(2302-2304)tcC>tcT	p.S768S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	768					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CTCAAAATTCCAAGGTTCAAG	0.284000													24	37					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55533728	55533728	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:55533728G>A	ENST00000220676.1	+	2	350	c.202G>A	c.(202-204)Gat>Aat	p.D68N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	68	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.D68N(1)		NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGCTCTGCTGGATAACTTGTC	0.597000													71	109					0	0	1	0	0
NMNAT2	23057	broad.mit.edu	37	1	183273853	183273853	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:183273853C>T	ENST00000294868.4	-	1	156	c.22G>A	c.(22-24)Gaa>Aaa	p.E8K	NMNAT2_ENST00000287713.6_Intron	NM_170706.3	NP_733820.1	Q9BZQ4	NMNA2_HUMAN	nicotinamide nucleotide adenylyltransferase 2	0					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	18						GCCTGAATTTCCTCTAGTTCC	0.542000													101	98					0	0	1	0	0
PIH1D1	55011	broad.mit.edu	37	19	49952896	49952896	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:49952896G>A	ENST00000262265.5	-	3	408	c.173C>T	c.(172-174)aCc>aTc	p.T58I	PIH1D1_ENST00000596049.1_Missense_Mutation_p.T58I	NM_017916.2	NP_060386.1	Q9NWS0	PIHD1_HUMAN	PIH1 domain containing 1	58					box C/D snoRNP assembly	pre-snoRNP complex				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|urinary_tract(1)	11		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		CGAGGAGTTGGTCTTTATGCA	0.537000													25	46					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94728527	94728527	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:94728527A>G	ENST00000283357.5	+	2	200	c.154A>G	c.(154-156)Act>Gct	p.T52A		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	52										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		TGCCTCTCCAACTGCGACTGC	0.408000													13	28					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196438152	196438152	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:196438152A>T	ENST00000367433.5	-	6	532	c.431T>A	c.(430-432)aTa>aAa	p.I144K	KCNT2_ENST00000294725.8_Missense_Mutation_p.I144K|KCNT2_ENST00000451324.2_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.I144K			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	144						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGCATTAATTATTTCCAAGAT	0.299000													17	17					0	0	1	0	0
SMCO3	440087	broad.mit.edu	37	12	14959082	14959082	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:14959082G>A	ENST00000316048.2	-	2	605	c.533C>T	c.(532-534)gCc>gTc	p.A178V	C12orf60_ENST00000330828.2_Intron|C12orf60_ENST00000527783.1_Intron	NM_001013698.2	NP_001013720.2			single-pass membrane protein with coiled-coil domains 3																		TCCCAGGATGGCACGGACAAT	0.423000													62	92					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111576501	111576501	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:111576501C>T	ENST00000261486.5	-	10	1078	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K	RP11-526F3.1_ENST00000504004.1_RNA	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	268	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding	p.E268K(1)		breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		AATGAGGTTTCGTTACACTAA	0.363000													20	47					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			154	130					0	0	1	0	0
MAU2	23383	broad.mit.edu	37	19	19454710	19454710	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:19454710C>T	ENST00000392313.5	+	10	1084	c.1038C>T	c.(1036-1038)tgC>tgT	p.C346C	MAU2_ENST00000262815.8_Silent_p.C346C|MAU2_ENST00000585823.2_3'UTR	NM_015329.3	NP_056144.3	Q9Y6X3	SCC4_HUMAN	MAU2 sister chromatid cohesion factor	346					cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	18						TCATCATGTGCCGCCTTGTCA	0.602000													61	102					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64681116	64681116	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:64681116C>T	ENST00000357395.3	+	107	19560	c.8416C>T	c.(8416-8418)Cac>Tac	p.H2806Y	SYNE2_ENST00000344113.4_Missense_Mutation_p.H6421Y|SYNE2_ENST00000458046.2_Missense_Mutation_p.H55Y|SYNE2_ENST00000555022.1_Missense_Mutation_p.H299Y|SYNE2_ENST00000394768.2_Missense_Mutation_p.H2806Y|SYNE2_ENST00000358025.3_Missense_Mutation_p.H6421Y|SYNE2_ENST00000555002.1_Missense_Mutation_p.H3055Y|SYNE2_ENST00000554805.1_Missense_Mutation_p.H204Y|SYNE2_ENST00000554584.1_Missense_Mutation_p.H6363Y|ESR2_ENST00000542956.1_Intron			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6421					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GGAGTGGGACCACACAGGCGA	0.642000													49	71					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10348323	10348323	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:10348323C>T	ENST00000255381.2	-	37	5546	c.5436G>A	c.(5434-5436)ggG>ggA	p.G1812G	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1812					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCTGCTTCTTCCCACCCTTCA	0.557000													68	112					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33560282	33560282	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:33560282G>A	ENST00000228567.3	-	3	815	c.519C>T	c.(517-519)tcC>tcT	p.S173S	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	173						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GTCTTCGGAAGGAACTGTGGC	0.438000													48	88					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27319175	27319175	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:27319175G>A	ENST00000407991.1	-	7	2169	c.1561C>T	c.(1561-1563)Ctg>Ttg	p.L521L	CHRNA2_ENST00000240132.2_Silent_p.L506L|CHRNA2_ENST00000520933.2_Silent_p.L521L	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	521						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AACGGAGGCAGAAAGAGGCCG	0.567000													46	88					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113536329	113536329	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:113536329C>T	ENST00000375630.2	+	29	3615	c.3527C>T	c.(3526-3528)tCc>tTc	p.S1176F	ATP11A_ENST00000487903.1_3'UTR|ATP11A_ENST00000375645.3_3'UTR	NM_032189.3	NP_115565.3	P98196	AT11A_HUMAN	ATPase, class VI, type 11A	0					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CACTGCAGTTCCATCCCAAGT	0.622000													64	107					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136567097	136567097	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:136567097C>T	ENST00000264162.2	-	8	2830	c.2820G>A	c.(2818-2820)ggG>ggA	p.G940G		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	940	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCACATTGCTCCCTGGTGTGT	0.542000													48	69					0	0	1	0	0
PIGZ	80235	broad.mit.edu	37	3	196678748	196678748	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:196678748G>C	ENST00000412723.1	-	2	301	c.155C>G	c.(154-156)cCg>cGg	p.P52R	PIGZ_ENST00000443835.1_Missense_Mutation_p.P52R	NM_025163.2	NP_079439.2	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Z	52					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			breast(1)|endometrium(1)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	14	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		GCCCGTCTGCGGAAGGAGACA	0.572000													20	39					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125281920	125281920	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:125281920C>T	ENST00000340750.1	+	1	501	c.501C>T	c.(499-501)tcC>tcT	p.S167S		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						CCCAGCTGTCCTTTTGTGCTG	0.493000													32	79					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33560247	33560247	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:33560247G>A	ENST00000228567.3	-	3	850	c.554C>T	c.(553-555)tCc>tTc	p.S185F	SYT10_ENST00000535526.1_Missense_Mutation_p.S4F	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	185						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					ATCAACACTGGAAACCTGCAT	0.433000													60	95					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113082376	113082376	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:113082376C>T	ENST00000393845.2	-	20	2785	c.2719G>A	c.(2719-2721)Gga>Aga	p.G907R	WDR52_ENST00000295868.2_Missense_Mutation_p.G907R	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	907										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						GTTTCAATTCCAAACTATAGG	0.343000													27	42					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567266	45567266	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:45567266C>T	ENST00000588982.1	-	3	714	c.213G>A	c.(211-213)caG>caA	p.Q71Q	ZBTB7C_ENST00000535628.2_Silent_p.Q71Q|ZBTB7C_ENST00000332053.2_Silent_p.Q71Q|ZBTB7C_ENST00000590800.1_Silent_p.Q71Q|ZBTB7C_ENST00000586438.1_Silent_p.Q71Q			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	71	BTB.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						AGACGTAGGGCTGGCTGGCTA	0.592000													47	44					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64488199	64488199	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:64488199C>T	ENST00000358025.3	+	36	5548	c.5318C>T	c.(5317-5319)cCt>cTt	p.P1773L	SYNE2_ENST00000344113.4_Missense_Mutation_p.P1773L|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Missense_Mutation_p.P1773L	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1773					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GCCCTGTCTCCTTCTGACAGC	0.488000													27	55					0	0	1	0	0
MEIS1	4211	broad.mit.edu	37	2	66798424	66798424	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:66798424G>A	ENST00000407092.2	+	12	1618	c.1161G>A	c.(1159-1161)atG>atA	p.M387I	MEIS1_ENST00000495021.2_3'UTR|MEIS1_ENST00000409517.1_3'UTR|MEIS1_ENST00000272369.9_3'UTR|MEIS1_ENST00000488550.1_3'UTR|MEIS1_ENST00000398506.2_Missense_Mutation_p.M385I|MEIS1_ENST00000444274.2_3'UTR			O00470	MEIS1_HUMAN	Meis homeobox 1	15	Required for transcriptional activation (By similarity).						sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						GTGGTCCAATGGGTGTGAGTA	0.493000													7	17					0	0	1	0	0
CENPP	401541	broad.mit.edu	37	9	95099878	95099878	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:95099878A>G	ENST00000375587.3	+	3	860	c.345A>G	c.(343-345)acA>acG	p.T115T		NM_001012267.1	NP_001012267.1	Q6IPU0	CENPP_HUMAN	centromere protein P	115					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(1)	16						ACATGGTTACATTTCAACTTG	0.333000													66	93					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4925382	4925382	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:4925382C>T	ENST00000396658.4	+	14	3674	c.2971C>T	c.(2971-2973)Ccg>Tcg	p.P991S	UBN1_ENST00000545171.1_Missense_Mutation_p.P991S|UBN1_ENST00000262376.6_Missense_Mutation_p.P991S|UBN1_ENST00000590769.1_Missense_Mutation_p.P991S	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	991	Ser-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						GCTGACCTCGCCGTCCCTAAA	0.572000													63	115					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24201912	24201912	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:24201912G>A	ENST00000536471.1	-	3	454	c.196C>T	c.(196-198)Cgg>Tgg	p.R66W	CNR2_ENST00000374472.4_Missense_Mutation_p.R66W			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	66					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	GAGGGCTTCCGGCGGAGTTGG	0.547000													39	76					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543603	28543603	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:28543603C>T	ENST00000452236.2	-	3	1496	c.879G>A	c.(877-879)ggG>ggA	p.G293G		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	293					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TATCTGTTTCCCCATTTACAG	0.408000													78	239					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200944036	200944036	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:200944036G>A	ENST00000332129.2	-	33	4897	c.4581C>T	c.(4579-4581)atC>atT	p.I1527I	KIF21B_ENST00000360529.5_Silent_p.I1527I|KIF21B_ENST00000461742.2_Silent_p.I1540I|KIF21B_ENST00000422435.2_Silent_p.I1540I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1540					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GCGCATTGGGGATTTGCTGTG	0.642000													44	116					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12645699	12645699	+	Missense_Mutation	SNP	G	G	A	rs80338796		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:12645699G>A	ENST00000251849.4	-	7	1209	c.770C>T	c.(769-771)tCg>tTg	p.S257L	RAF1_ENST00000542177.1_Missense_Mutation_p.S176L|RAF1_ENST00000442415.2_Missense_Mutation_p.S257L|RAF1_ENST00000534997.1_Missense_Mutation_p.S42L	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	257			S -> L (in NS5 and LEOPARD2; shows in vitro greater kinase activity and enhanced ERK activation than wild-type).		activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity	p.S257L(3)|p.S257W(1)	ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	TGTGGATGTCGACCTCTGCCT	0.527000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				37	62					0	0	1	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722308	64722308	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:64722308G>A	ENST00000338957.4	+	5	1797	c.1730G>A	c.(1729-1731)cGg>cAg	p.R577Q	ZC3H12B_ENST00000423889.3_Missense_Mutation_p.R566Q	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	566							endonuclease activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GTGTATGCCCGGAATCCTAAC	0.468000													22	3					0	0	1	0	0
MSL3P1	151507	broad.mit.edu	37	2	234774686	234774686	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:234774686C>T	ENST00000438684.1	-	0	1428					NR_024322.1																						GTTTTGTGCTCTGGATAAAAA	0.423000													4	1					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021829	132021829	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:132021829C>T	ENST00000356920.5	+	15	2895	c.2801C>T	c.(2800-2802)tCc>tTc	p.S934F	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	934	Actin-like.						ATP binding										GCCTCCAGCTCCTCCCTAGAG	0.622000													8	392					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62550966	62550966	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:62550966C>T	ENST00000430451.2	+	5	1684	c.1487C>T	c.(1486-1488)tCa>tTa	p.S496L		NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	496										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GATAGTACTTCATCCACGCAG	0.552000													65	103					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50763780	50763780	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:50763780C>T	ENST00000300589.2	+	11	3123	c.3018C>T	c.(3016-3018)gcC>gcT	p.A1006A		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	1006					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TCCTGCAGGCCCTTGAAAGGA	0.493000													22	38					0	0	1	0	0
HGFAC	3083	broad.mit.edu	37	4	3446379	3446379	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:3446379G>A	ENST00000382774.3	+	7	875	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	HGFAC_ENST00000511533.1_Missense_Mutation_p.G254S	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	254	EGF-like 2.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCTGAACGGGGGCACCTGCCA	0.721000													10	12					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23232545	23232545	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:23232545G>A	ENST00000400191.3	+	10	1849	c.1831G>A	c.(1831-1833)Gag>Aag	p.E611K	EPHB2_ENST00000374630.3_Missense_Mutation_p.E611K|EPHB2_ENST00000374627.1_Missense_Mutation_p.E606K|EPHB2_ENST00000374632.3_Missense_Mutation_p.E612K	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	611					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GGCAGTGCGGGAGTTTGCCAA	0.522000													16	38					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55708576	55708576	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:55708576C>T	ENST00000376350.3	-	9	1921	c.1899G>A	c.(1897-1899)gaG>gaA	p.E633E	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Silent_p.E455E	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	633	Fibronectin type-III 7.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GTTCCAGGGCCTCCACTTTGT	0.582000													48	75					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51135724	51135724	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:51135724C>T	ENST00000338916.4	-	2	1126	c.493G>A	c.(493-495)Gac>Aac	p.D165N	SYT3_ENST00000593901.1_Missense_Mutation_p.D165N|SYT3_ENST00000544769.1_Missense_Mutation_p.D165N|SYT3_ENST00000600079.1_Missense_Mutation_p.D165N	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	165						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GGATACGAGTCCATGTCCAAG	0.647000													19	38					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713875	142713875	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:142713875G>A	ENST00000369381.2	-	0	730																											TCCTGATTATGAAAATCCTAA	0.299000													10	105					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135095839	135095839	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:135095839C>T	ENST00000409645.1	+	7	907	c.655C>T	c.(655-657)Cgt>Tgt	p.R219C	MGAT5_ENST00000281923.2_Missense_Mutation_p.R219C			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	219					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		GGCGGAAATTCGTACAGATTT	0.368000													17	50					0	0	1	0	0
LOC93432	93432	broad.mit.edu	37	7	141896588	141896588	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:141896588C>T	ENST00000477922.3	+	40	4658	c.4604C>T	c.(4603-4605)tCc>tTc	p.S1535F																	endometrium(1)|lung(5)	6						TATCCATTTTCCAGAAACCAC	0.463000													6	17					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111463936	111463936	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:111463936G>A	ENST00000265162.5	+	12	2179	c.1837G>A	c.(1837-1839)Gga>Aga	p.G613R		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	613					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding	p.G613*(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TAATCCTAGTGGAAATGCTTT	0.383000													39	89					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69058566	69058566	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:69058566C>T	ENST00000288368.4	+	34	4487	c.4210C>T	c.(4210-4212)Cat>Tat	p.H1404Y		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1404					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GTTTAAAATTCATCCTGTTCT	0.318000													43	70					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31809560	31809560	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:31809560C>T	ENST00000446923.2	+	7	1640	c.1249C>T	c.(1249-1251)Caa>Taa	p.Q417*	ZEB1_ENST00000542815.3_Nonsense_Mutation_p.Q366*|ZEB1_ENST00000560721.2_Nonsense_Mutation_p.Q413*|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000320985.10_Nonsense_Mutation_p.Q433*|ZEB1_ENST00000361642.5_Nonsense_Mutation_p.Q434*	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	433					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GGAGAATAATCAAGCCAATCT	0.383000													30	62					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42085041	42085041	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:42085041G>A	ENST00000395925.3	-	6	852	c.768C>T	c.(766-768)ccC>ccT	p.P256P	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	256					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TGGCAGCTGAGGGAATAATGT	0.557000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				64	115					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101375456	101375456	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:101375456G>A	ENST00000344327.3	-	2	668	c.244C>T	c.(244-246)Cga>Tga	p.R82*	TRPC6_ENST00000526713.1_5'UTR|TRPC6_ENST00000532133.1_Nonsense_Mutation_p.R82*|TRPC6_ENST00000348423.4_Nonsense_Mutation_p.R82*|TRPC6_ENST00000360497.4_Nonsense_Mutation_p.R82*	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	82					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GCTGGTCCTCGATTAGCTAAC	0.493000													68	114					0	0	1	0	0
SCEL	8796	broad.mit.edu	37	13	78176801	78176801	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:78176801C>T	ENST00000535157.1	+	16	1094	c.924C>T	c.(922-924)ctC>ctT	p.L308L	SCEL_ENST00000469982.1_Intron|SCEL-AS1_ENST00000456280.2_RNA|SCEL-AS1_ENST00000457528.2_RNA|SCEL_ENST00000377246.3_Silent_p.L310L|SCEL_ENST00000349847.3_Silent_p.L330L	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	330	16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		GACAAAATCTCGAATCTGTTG	0.338000													45	87					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60557996	60557996	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:60557996C>T	ENST00000400324.4	-	13	1607	c.1387G>A	c.(1387-1389)Gag>Aag	p.E463K	DIAPH3_ENST00000400330.1_Missense_Mutation_p.E463K|DIAPH3_ENST00000377908.2_Missense_Mutation_p.E452K|DIAPH3_ENST00000267215.4_Missense_Mutation_p.E463K|DIAPH3_ENST00000465066.1_5'UTR|DIAPH3_ENST00000400319.1_Missense_Mutation_p.E393K|DIAPH3_ENST00000400320.1_Missense_Mutation_p.E417K	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	463	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GATACACACTCATCAATTAAT	0.313000													58	92					0	0	1	0	0
TRAV12-2	28673	broad.mit.edu	37	14	22356055	22356055	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:22356055G>A	ENST00000390437.2	+	0	19																											TTCTTTTTATGATTTTTAAAG	0.383000													6	7					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209778984	209778984	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:209778984C>T	ENST00000009105.1	+	5	645	c.400C>T	c.(400-402)Cta>Tta	p.L134L	CAMK1G_ENST00000361322.2_Silent_p.L134L			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	134	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		AGTGAAATACCTACATGAGAA	0.532000													37	135					0	0	1	0	0
UTS2	10911	broad.mit.edu	37	1	7912982	7912982	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:7912982C>T	ENST00000377516.2	-	2	402	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	UTS2_ENST00000361696.5_Missense_Mutation_p.E28K|UTS2_ENST00000054668.5_Splice_Site_p.E43_splice			O95399	UTS2_HUMAN	urotensin 2	28					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity			kidney(1)|lung(4)|urinary_tract(1)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		AAGGATATTTCCCTGGAGTCA	0.378000													122	91					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152287830	152287830	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:152287830C>T	ENST00000368799.1	-	2	138	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	35	EF-hand 1.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAGAAGTTCCTTCAGCTCT	0.348000									Ichthyosis				62	195					0	0	1	0	0
SKAP2	8935	broad.mit.edu	37	7	26765109	26765109	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:26765109G>A	ENST00000345317.2	-	9	1047	c.734C>T	c.(733-735)cCa>cTa	p.P245L	SKAP2_ENST00000489977.1_5'UTR|SKAP2_ENST00000539623.1_Missense_Mutation_p.P73L	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	245					B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						ATTGCTTATTGGTAGAGGATG	0.318000													26	59					0	0	1	0	0
PVRL1	5818	broad.mit.edu	37	11	119548540	119548540	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:119548540G>A	ENST00000264025.3	-	3	988	c.458C>T	c.(457-459)aCc>aTc	p.T153I	PVRL1_ENST00000340882.2_Missense_Mutation_p.T153I|PVRL1_ENST00000341398.2_Missense_Mutation_p.T153I|PVRL1_ENST00000524510.1_5'UTR	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	153	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CACTGCCTGGGTACCCTCTAT	0.582000													27	36					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17697254	17697254	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:17697254C>T	ENST00000353383.1	+	3	1461	c.992C>T	c.(991-993)cCa>cTa	p.P331L	RAI1_ENST00000261641.6_Missense_Mutation_p.P331L	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	331	Gln-rich.					cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GTCCGGACCCCAGAGCAGTAC	0.642000													82	149					0	0	1	0	0
STRA6	64220	broad.mit.edu	37	15	74473149	74473149	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:74473149C>T	ENST00000323940.5	-	18	2059	c.1814G>A	c.(1813-1815)aGc>aAc	p.S605N	STRA6_ENST00000563965.1_Missense_Mutation_p.S644N|STRA6_ENST00000423167.2_Missense_Mutation_p.S596N|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000449139.2_Missense_Mutation_p.S605N|STRA6_ENST00000535552.1_Missense_Mutation_p.S642N|STRA6_ENST00000574278.1_Missense_Mutation_p.S620N|STRA6_ENST00000416286.3_Missense_Mutation_p.S597N|STRA6_ENST00000395105.4_Missense_Mutation_p.S605N	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	605					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						TGGTCTGAGGCTGTCCTGGGG	0.617000													42	82					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219920312	219920312	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:219920312C>T	ENST00000295731.5	-	3	852	c.853G>A	c.(853-855)Gag>Aag	p.E285K		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	285					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTGCCGGCTCCGTGTGATTG	0.677000													16	29					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64748639	64748639	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:64748639C>T	ENST00000536360.1	-	5	1551	c.738G>A	c.(736-738)gtG>gtA	p.V246V				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	246					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GTTCAATGCTCACTGATCTCT	0.433000													49	86					0	0	1	0	0
ENGASE	64772	broad.mit.edu	37	17	77082115	77082115	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:77082115C>T	ENST00000579016.1	+	14	1916	c.1916C>T	c.(1915-1917)cCc>cTc	p.P639L		NM_001042573.2	NP_001036038.1	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	639						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						CGGGAGGGGCCCCCTGCTCTG	0.657000													35	59					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31540608	31540608	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:31540608G>A	ENST00000389082.5	-	21	4018	c.3754C>T	c.(3754-3756)Cga>Tga	p.R1252*	DENND5B_ENST00000306833.6_Nonsense_Mutation_p.R1287*|DENND5B_ENST00000536562.1_Nonsense_Mutation_p.R1287*	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1252	RUN 2.					integral to membrane		p.R1252*(1)		NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						TGCAGAATTCGGATAAGGGAG	0.488000													24	39					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064338	9064338	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:9064338G>A	ENST00000397910.4	-	3	23311	c.23108C>T	c.(23107-23109)tCc>tTc	p.S7703F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7705	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAATGTGGTGGAAACAGGATG	0.562000													43	64					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188198	7188198	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:7188198C>T	ENST00000542285.1	-	11	1749	c.1600G>A	c.(1600-1602)Gac>Aac	p.D534N				P00736	C1R_HUMAN	complement component 1, r subcomponent	586	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AAGCCCAGGTCGTAGAAGGTA	0.562000													28	39					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72163754	72163754	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:72163754C>T	ENST00000357731.4	-	4	843	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	NEGR1_ENST00000306821.3_Missense_Mutation_p.E74K|NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000434200.1_Intron	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	202	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GCACTGCATTCATATTCCCCA	0.353000													30	55					0	0	1	0	0
KCTD13	253980	broad.mit.edu	37	16	29918198	29918198	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:29918198C>T	ENST00000568000.1	-	6	1986	c.985G>A	c.(985-987)Gac>Aac	p.D329N		NM_178863.3	NP_849194.1	Q8WZ19	BACD1_HUMAN	potassium channel tetramerization domain containing 13	329					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	7						AGAGGTCAGTCCTTGAAGACA	0.602000													29	45					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227966606	227966606	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:227966606C>T	ENST00000396625.3	-	16	1157	c.950G>A	c.(949-951)gGa>gAa	p.G317E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G317E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	317	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ACCTGGAGATCCATAGGAACC	0.313000													8	8					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122130171	122130171	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:122130171G>A	ENST00000334010.7	-	11	2237	c.1816C>T	c.(1816-1818)Cct>Tct	p.P606S	CADPS2_ENST00000449022.2_Missense_Mutation_p.P606S|CADPS2_ENST00000313070.7_Missense_Mutation_p.P606S|CADPS2_ENST00000412584.2_Missense_Mutation_p.P606S	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	606					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						CCTCCTTTAGGATTCAGTTTC	0.348000													38	54					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26211990	26211990	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:26211990C>T	ENST00000379034.1	+	2	176	c.27C>T	c.(25-27)ctC>ctT	p.L9L		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	9										breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						AGAGTAAGCTCCGTACCTGTG	0.582000													38	15					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23524492	23524492	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:23524492C>T	ENST00000296682.3	+	10	1182	c.1000C>T	c.(1000-1002)Cag>Tag	p.Q334*		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	334	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGTGGCCTTCCAGTACCACAG	0.537000										HNSCC(3;0.000094)			26	62					0	0	1	0	0
LOC100129935	100129935	broad.mit.edu	37	19	40132963	40132963	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:40132963G>A	ENST00000594263.1	+	0	1753					NR_026870.1																						GTGACCATAGGATCCCCAGAG	0.463000													3	5					0	0	1	0	0
MARCH2	51257	broad.mit.edu	37	19	8491631	8491631	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:8491631C>T	ENST00000602117.1	+	3	770	c.315C>T	c.(313-315)taC>taT	p.Y105Y	MARCH2_ENST00000601283.1_Intron|RP11-886P16.6_ENST00000595706.1_RNA|MARCH2_ENST00000215555.2_Silent_p.Y105Y|MARCH2_ENST00000381035.4_Silent_p.Y105Y|MARCH2_ENST00000393944.1_Silent_p.Y105Y			Q9P0N8	MARH2_HUMAN	membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase	105					endocytosis	cytoplasmic vesicle|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|skin(1)|urinary_tract(1)	10						ACACCAGCTACTGCGAGCTGT	0.607000													26	55					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31594485	31594485	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:31594485G>A	ENST00000319386.3	+	4	1219	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	CCDC129_ENST00000407970.3_Missense_Mutation_p.E76K|CCDC129_ENST00000451887.2_Missense_Mutation_p.E102K|CCDC129_ENST00000482748.1_3'UTR|CCDC129_ENST00000409210.1_5'UTR			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	76										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CTCTGCAAATGAAAACTTTCA	0.323000													5	3					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29820946	29820946	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:29820946C>T	ENST00000375398.2	-	11	2443	c.1994G>A	c.(1993-1995)cGa>cAa	p.R665Q	SVIL_ENST00000375400.3_Intron|SVIL_ENST00000355867.4_Missense_Mutation_p.R665Q			O95425	SVIL_HUMAN	supervillin	665					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CGATTCCTTTCGTTCTGCTGA	0.478000													79	124					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16003236	16003236	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:16003236G>A	ENST00000221700.5	-	5	503	c.408C>T	c.(406-408)ctC>ctT	p.L136L	CYP4F2_ENST00000592328.1_Silent_p.L136L|CYP4F2_ENST00000011989.7_5'UTR	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	136					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CACTCAGCAGGAGCCCATCCC	0.577000													52	78					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929509	121929509	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:121929509C>T	ENST00000265922.3	-	8	2600	c.2139G>A	c.(2137-2139)ggG>ggA	p.G713G	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		713					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GCTGGGGTTTCCCCGGGGCCA	0.552000													57	102					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39222597	39222597	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:39222597T>G	ENST00000333039.2	-	3	1129	c.1006A>C	c.(1006-1008)Acc>Ccc	p.T336P		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	336	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					GAGAAGGGGGTGCCCTGGCCG	0.642000													47	90					0	0	1	0	0
TERF2IP	54386	broad.mit.edu	37	16	75682397	75682397	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:75682397C>T	ENST00000300086.4	+	1	714	c.617C>T	c.(616-618)tCc>tTc	p.S206F		NM_018975.3	NP_061848.2	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting protein	206					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)	5						AGCCCCTCCTCCCAGAAGCTC	0.701000													5	9					0	0	1	0	0
FRMD8	83786	broad.mit.edu	37	11	65164292	65164292	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:65164292C>T	ENST00000317568.5	+	7	767	c.604C>T	c.(604-606)Cct>Tct	p.P202S	FRMD8_ENST00000355991.5_Missense_Mutation_p.P146S|FRMD8_ENST00000416776.2_Missense_Mutation_p.P168S	NM_031904.3	NP_114110.1	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	202	FERM.					cytoskeleton	binding	p.P202S(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|urinary_tract(1)	17						CTCCTTCCTCCCTGCCCACCT	0.697000													3	9					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58967343	58967343	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:58967343C>T	ENST00000391696.1	+	3	1934	c.1002C>T	c.(1000-1002)tcC>tcT	p.S334S	ZNF324B_ENST00000545523.1_Silent_p.S344S|ZNF324B_ENST00000336614.4_Silent_p.S344S			Q6AW86	Z324B_HUMAN	zinc finger protein 324B	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TCCGCTGCTCCGAGTGCGGCA	0.687000													25	16					0	0	1	0	0
ZNF431	170959	broad.mit.edu	37	19	21366788	21366788	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:21366788C>T	ENST00000311048.7	+	5	1826	c.1682C>T	c.(1681-1683)tCa>tTa	p.S561L	ZNF431_ENST00000600692.1_3'UTR|ZNF431_ENST00000594425.1_Intron	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	561					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						CAAAATAATTCATACTGGAGA	0.368000													18	35					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167625870	167625870	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:167625870C>T	ENST00000519204.1	+	15	2668	c.2550C>T	c.(2548-2550)atC>atT	p.I850I	TENM2_ENST00000403607.2_Silent_p.I795I|TENM2_ENST00000518659.1_Silent_p.I971I|TENM2_ENST00000520394.1_Silent_p.I739I|TENM2_ENST00000545108.1_Silent_p.I971I					teneurin transmembrane protein 2																		TCGACCTGATCGCAAATGGAG	0.562000													54	99					0	0	1	0	0
LALBA	3906	broad.mit.edu	37	12	48961786	48961786	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:48961786G>A	ENST00000301046.2	-	4	408	c.383C>T	c.(382-384)gCc>gTc	p.A128V	LALBA_ENST00000549817.1_3'UTR	NM_002289.2	NP_002280.1	P00709	LALBA_HUMAN	lactalbumin, alpha-	128					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity			large_intestine(1)|stomach(2)	3						AGTGCAGAGGGCTTTATGGGC	0.522000													9	10					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43710238	43710238	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr21:43710238G>A	ENST00000398437.1	+	12	1925	c.1777G>A	c.(1777-1779)Gaa>Aaa	p.E593K	ABCG1_ENST00000361802.2_Missense_Mutation_p.E447K|ABCG1_ENST00000398457.2_Missense_Mutation_p.E437K|ABCG1_ENST00000343687.3_Missense_Mutation_p.E446K|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000340588.4_Missense_Mutation_p.E555K|ABCG1_ENST00000398449.3_Missense_Mutation_p.E435K|ABCG1_ENST00000347800.2_Missense_Mutation_p.E432K			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	447	ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	GATCGGGAACGAAGCCAAGAA	0.562000													60	125					0	0	1	0	0
GALNS	2588	broad.mit.edu	37	16	88909220	88909220	+	Silent	SNP	G	G	A	rs140588640		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:88909220G>A	ENST00000268695.5	-	2	226	c.138C>T	c.(136-138)ctC>ctT	p.L46L	GALNS_ENST00000542788.1_Intron|GALNS_ENST00000565364.1_5'UTR	NM_000512.4	NP_000503.1	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	46						lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(8)	22				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	CATACACCCCGAGGTCACCCC	0.602000													17	18					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88780634	88780634	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:88780634G>A	ENST00000418177.2	-	2	774	c.407C>T	c.(406-408)tCc>tTc	p.S136F	GRM5_ENST00000455756.2_Missense_Mutation_p.S136F|GRM5_ENST00000393294.3_Missense_Mutation_p.S136F|GRM5_ENST00000393297.1_Missense_Mutation_p.S136F|GRM5_ENST00000305432.5_Missense_Mutation_p.S136F|GRM5_ENST00000305447.4_Missense_Mutation_p.S136F			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	136					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.S136Y(2)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GGAGCGGAAGGAAGAGGAGGA	0.512000													68	25					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209180027	209180027	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:209180027A>C	ENST00000264380.4	+	15	2095	c.1937A>C	c.(1936-1938)cAg>cCg	p.Q646P		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	646					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CAGGTTGTTCAGACAGTCCGA	0.453000													28	45					0	0	1	0	0
MPHOSPH6	10200	broad.mit.edu	37	16	82185039	82185039	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:82185039G>A	ENST00000258169.4	-	3	295	c.245C>T	c.(244-246)cCt>cTt	p.P82L	MPHOSPH6_ENST00000563504.1_Missense_Mutation_p.P53L	NM_005792.2	NP_005783.2	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6	82					M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding			endometrium(1)|large_intestine(1)|lung(3)	5						CTCAACCTCAGGATTAAATCC	0.308000													31	55					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47408146	47408146	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:47408146G>A	ENST00000398879.1	-	17	2463	c.2097C>T	c.(2095-2097)atC>atT	p.I699I	TNS3_ENST00000355730.3_Silent_p.I459I|TNS3_ENST00000311160.9_Silent_p.I699I			Q68CZ2	TENS3_HUMAN	tensin 3	699						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGAGCTGCTCGATGGACTGGT	0.627000													123	202					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69748027	69748027	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:69748027G>A	ENST00000409085.4	-	11	1525	c.1149C>T	c.(1147-1149)ccC>ccT	p.P383P	AAK1_ENST00000406297.3_Silent_p.P383P|AAK1_ENST00000409068.1_Silent_p.P383P	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	383						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						CTGGCTGGATGGGAAGGATTC	0.547000													69	107					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8192441	8192441	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:8192441C>T	ENST00000162391.3	+	2	1158	c.13C>T	c.(13-15)Cta>Tta	p.L5L	FOXJ2_ENST00000428177.2_Silent_p.L5L	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	5					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		GGCTTCTGACCTAGAGAGTAG	0.532000													60	108					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739391	38739391	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:38739391G>A	ENST00000449082.2	-	27	5319	c.5320C>T	c.(5320-5322)Ccc>Tcc	p.P1774S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1774					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ATTCTCAGGGGACCAGAGAGA	0.468000													43	75					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42848889	42848889	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:42848889C>T	ENST00000334370.4	+	12	2636	c.2001C>T	c.(1999-2001)ttC>ttT	p.F667F	MEGF8_ENST00000251268.6_Silent_p.F667F	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	717						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CGCCTGTCTTCGTCACGTCCC	0.672000													33	68					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46211644	46211644	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:46211644C>T	ENST00000334344.6	+	5	782	c.610C>T	c.(610-612)Ctt>Ttt	p.L204F	ARID2_ENST00000422737.1_Missense_Mutation_p.L55F	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	204					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CACTTTACTACTTGCTAATGC	0.328000			"""N, S, F"""		hepatocellular carcinoma								26	38					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196642628	196642628	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:196642628T>A	ENST00000312428.6	-	59	11060	c.10960A>T	c.(10960-10962)Acg>Tcg	p.T3654S	DNAH7_ENST00000409063.1_Missense_Mutation_p.T137S	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3654					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTGCGCAGCGTGCGCCGGTCC	0.478000													32	43					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21971126	21971126	+	Silent	SNP	C	C	T	rs140182559	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:21971126C>T	ENST00000261200.4	-	30	3728	c.3729G>A	c.(3727-3729)tcG>tcA	p.S1243S	ABCC9_ENST00000345162.2_Silent_p.S1207S|ABCC9_ENST00000261201.4_Silent_p.S1243S	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1243	ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATCCAGAATTCGAAGACCCAC	0.408000													68	153					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176993856	176993856	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:176993856C>T	ENST00000367654.2	-	6	1146	c.1133G>A	c.(1132-1134)cGa>cAa	p.R378Q	ASTN1_ENST00000361833.2_Missense_Mutation_p.R378Q|ASTN1_ENST00000367657.3_Missense_Mutation_p.R378Q|ASTN1_ENST00000424564.2_Missense_Mutation_p.R378Q|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	378					cell migration|neuron cell-cell adhesion	integral to membrane		p.R378Q(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CACAGGACTTCGGGGAGAACC	0.493000													22	34					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149247552	149247552	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:149247552C>T	ENST00000407073.1	+	12	4649	c.3652C>T	c.(3652-3654)Cat>Tat	p.H1218Y	MBD5_ENST00000404807.1_Missense_Mutation_p.H1451Y	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1218						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATTTTTAGATCATCCAGGCCA	0.498000													44	84					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124350590	124350590	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:124350590G>A	ENST00000409039.3	+	40	6808	c.6783G>A	c.(6781-6783)tgG>tgA	p.W2261*		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2261	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GACCATACTGGAAAAAATGGG	0.348000													20	42					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96963125	96963125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:96963125C>T	ENST00000389672.5	+	5	1638	c.1600C>T	c.(1600-1602)Caa>Taa	p.Q534*	EPHA6_ENST00000470610.2_Nonsense_Mutation_p.Q534*	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	439						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GACCACGGATCAAGATGGTAA	0.403000													44	75					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37454063	37454063	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:37454063G>A	ENST00000374660.1	+	18	1975	c.1876G>A	c.(1876-1878)Gaa>Aaa	p.E626K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E626K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E626K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	682						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GGACTATGAAGAAAATTCTTG	0.289000													33	58					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55321881	55321881	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:55321881C>T	ENST00000314644.2	+	1	99	c.99C>T	c.(97-99)ttC>ttT	p.F33F		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						AGCAAATTTTCCTTTGTCCTA	0.368000										HNSCC(20;0.049)			64	126					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56434752	56434752	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:56434752A>T	ENST00000370754.5	-	54	13686	c.13687T>A	c.(13687-13689)Tca>Aca	p.S4563T	DST_ENST00000370769.4_Missense_Mutation_p.S4385T|DST_ENST00000421834.2_Missense_Mutation_p.S2297T|DST_ENST00000312431.6_3'UTR|DST_ENST00000361203.3_Missense_Mutation_p.S4383T|DST_ENST00000244364.6_Missense_Mutation_p.S1971T|DST_ENST00000370788.2_Missense_Mutation_p.S2297T|DST_ENST00000446842.2_Missense_Mutation_p.S4059T			Q03001	DYST_HUMAN	dystonin	4383					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GACTTCAATGATTTAACAAGA	0.333000													29	20					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31747282	31747282	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:31747282G>A	ENST00000375663.3	-	28	3760	c.3320C>T	c.(3319-3321)gCc>gTc	p.A1107V		NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1107					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	CAGCTCAAGGGCGGCTTCTGC	0.687000													22	10					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46717864	46717864	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:46717864C>T	ENST00000318962.4	-	19	2140	c.2057G>A	c.(2056-2058)gGa>gAa	p.G686E	ALS2CL_ENST00000415953.1_Missense_Mutation_p.G686E|ALS2CL_ENST00000383742.3_Missense_Mutation_p.G33E	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	686					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity	p.G686E(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GAGCAGCTTTCCCAGGGGGTG	0.617000													41	89					0	0	1	0	0
TRBV28	28559	broad.mit.edu	37	7	142428720	142428720	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:142428720C>T	ENST00000390400.2	+	0	100																											ACCCAGAGCTCGAGATATCTA	0.448000													16	23					0	0	1	0	0
PPP6R2	9701	broad.mit.edu	37	22	50832548	50832548	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:50832548G>A	ENST00000359139.3	+	3	605	c.211G>A	c.(211-213)Gag>Aag	p.E71K	PPP6R2_ENST00000216061.5_Missense_Mutation_p.E71K|PPP6R2_ENST00000395741.3_Missense_Mutation_p.E71K|PPP6R2_ENST00000395744.3_Missense_Mutation_p.E71K	NM_001242898.1|NM_001242899.1|NM_001242900.1|NM_014678.4	NP_001229827.1|NP_001229828.1|NP_001229829.1|NP_055493.2	O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	71						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						GGACATGGAGGAGAAGGTCCG	0.592000													69	81					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72746489	72746489	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:72746489G>A	ENST00000377182.4	+	7	1572	c.955G>A	c.(955-957)Gat>Aat	p.D319N	MAMDC2-AS1_ENST00000591368.1_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	319	MAM 2.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						TGCCCTGGATGATATTTCATT	0.413000													73	107					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105459626	105459626	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:105459626C>T	ENST00000351513.2	-	3	661	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	177					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGAAGGCTTCGTACAGCTCC	0.428000													48	82					0	0	1	0	0
AGMO	392636	broad.mit.edu	37	7	15584536	15584536	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:15584536C>T	ENST00000342526.3	-	3	439	c.270G>A	c.(268-270)agG>agA	p.R90R		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	90					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding	p.R90S(1)		breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						GTTCAATGCTCCTGAAAAATA	0.313000													44	93					0	0	1	0	0
FCF1	51077	broad.mit.edu	37	14	75200844	75200844	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:75200844A>G	ENST00000341162.4	+	7	573	c.519A>G	c.(517-519)ggA>ggG	p.G173G	FCF1_ENST00000553615.1_Silent_p.G158G|FCF1_ENST00000534938.2_Silent_p.G161G	NM_015962.4	NP_057046.1	Q9Y324	FCF1_HUMAN	FCF1 rRNA-processing protein	173					rRNA processing	nucleolus				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(234;0.0037)		AGATTCCTGGAGTTCCTATCA	0.383000													17	50					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55826536	55826536	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:55826536G>A	ENST00000373965.2	-	19	2616	c.2222C>T	c.(2221-2223)gCc>gTc	p.A741V	PCDH15_ENST00000373957.3_Missense_Mutation_p.A712V|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.A734V|PCDH15_ENST00000437009.1_Missense_Mutation_p.A663V|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.A739V|PCDH15_ENST00000395438.1_Missense_Mutation_p.A734V|PCDH15_ENST00000320301.6_Missense_Mutation_p.A734V|PCDH15_ENST00000373955.1_Missense_Mutation_p.A734V|PCDH15_ENST00000395432.2_Missense_Mutation_p.A697V|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.A734V|PCDH15_ENST00000409834.1_Missense_Mutation_p.A345V|PCDH15_ENST00000395445.1_Missense_Mutation_p.A741V|PCDH15_ENST00000395433.1_Missense_Mutation_p.A712V	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	734	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCCACAAAGGCATTGGCTTC	0.338000										HNSCC(58;0.16)			27	58					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533433	92533433	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:92533433C>T	ENST00000298047.6	+	9	7271	c.7254C>T	c.(7252-7254)gcC>gcT	p.A2418A	FAT3_ENST00000525166.1_Silent_p.A2268A|FAT3_ENST00000409404.2_Silent_p.A2418A			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2418	Cadherin 22.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGTACAAGCCTCTGATGCAG	0.443000										TCGA Ovarian(4;0.039)			46	91					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19429316	19429316	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:19429316C>T	ENST00000261537.6	+	17	2817	c.2553C>T	c.(2551-2553)ctC>ctT	p.L851L	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	851					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			AGAAATGCCTCATCTGTAAAG	0.338000													47	74					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101724397	101724397	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:101724397C>T	ENST00000506729.1	-	12	2183	c.2012G>A	c.(2011-2013)gGa>gAa	p.G671E	SLCO6A1_ENST00000379807.3_Missense_Mutation_p.G671E|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.G418E|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.G609E|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.G418E			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	671						integral to membrane|plasma membrane	transporter activity	p.G671A(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CTTACATATTCCTACCAATAA	0.269000													12	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071478	9071478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:9071478C>T	ENST00000397910.4	-	3	16171	c.15968G>A	c.(15967-15969)tGg>tAg	p.W5323*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5325	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTTGTCATCCATGACACATT	0.532000													38	51					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97331067	97331067	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:97331067C>T	ENST00000266742.4	+	9	1352	c.1013C>T	c.(1012-1014)tCc>tTc	p.S338F	NEDD1_ENST00000457368.2_Missense_Mutation_p.S249F|NEDD1_ENST00000557644.1_Missense_Mutation_p.S345F|NEDD1_ENST00000411739.2_Missense_Mutation_p.S249F|NEDD1_ENST00000429527.2_Missense_Mutation_p.S338F	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	338					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol				breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						GTTCAGAATTCCGGAATTGTC	0.423000													57	88					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77353396	77353396	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:77353396C>T	ENST00000451710.3	-	35	5952	c.5715G>A	c.(5713-5715)gaG>gaA	p.E1905E	TRPM6_ENST00000376864.4_Silent_p.E1905E|TRPM6_ENST00000449912.2_Silent_p.E1896E|TRPM6_ENST00000376871.3_Silent_p.E738E|TRPM6_ENST00000376872.3_Silent_p.E856E|TRPM6_ENST00000361255.3_Silent_p.E1896E|TRPM6_ENST00000360774.1_Silent_p.E1901E			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1901	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						ACATCAGCTCCTCCAGGGTGT	0.468000													42	68					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961368	73961368	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:73961368G>A	ENST00000373468.1	-	3	3675	c.3024C>T	c.(3022-3024)tcC>tcT	p.S1008S	KIAA2022_ENST00000055682.5_Silent_p.S1008S			Q5QGS0	K2022_HUMAN	KIAA2022	1008					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TCAAGCTTAAGGAGCAATAAT	0.478000													27	12					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39051792	39051792	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:39051792C>T	ENST00000355481.4	+	89	12438	c.12307C>T	c.(12307-12309)Cag>Tag	p.Q4103*	RYR1_ENST00000360985.3_Nonsense_Mutation_p.Q4103*|RYR1_ENST00000359596.3_Nonsense_Mutation_p.Q4108*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4108					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCCAGAAATCCAGTTCCTGCT	0.567000													38	62					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65103431	65103431	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:65103431G>A	ENST00000358691.5	-	31	5261	c.5095C>T	c.(5095-5097)Ccc>Tcc	p.P1699S	HELZ_ENST00000580168.1_Missense_Mutation_p.P1700S	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGGCCATAGGGAAAACCTGGC	0.483000													56	118					0	0	1	0	0
SLC39A13	91252	broad.mit.edu	37	11	47431928	47431928	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:47431928A>C	ENST00000524928.1	+	1	293	c.283A>C	c.(283-285)Acc>Ccc	p.T95P	SLC39A13_ENST00000531974.1_Missense_Mutation_p.T95P|SLC39A13_ENST00000362021.4_Missense_Mutation_p.T95P|SLC39A13_ENST00000354884.4_Missense_Mutation_p.T95P|SLC39A13_ENST00000533076.1_Missense_Mutation_p.T95P			Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter), member 13	95					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|kidney(1)|lung(1)|prostate(1)	4				Lung(87;0.0936)		AGAGATGGGGACCATGCTGCG	0.632000													24	60					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96034328	96034328	+	Missense_Mutation	SNP	C	C	T	rs145603966		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:96034328C>T	ENST00000358812.4	+	2	147	c.13C>T	c.(13-15)Cgg>Tgg	p.R5W	MANEA_ENST00000369293.1_Missense_Mutation_p.R5W	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	5					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		GGCAAAGTTTCGGAGAAGGAC	0.313000													51	25					0	0	1	0	0
CD101	9398	broad.mit.edu	37	1	117576493	117576493	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:117576493C>T	ENST00000256652.4	+	9	2894	c.2836C>T	c.(2836-2838)Cct>Tct	p.P946S	RP11-27K13.3_ENST00000445523.1_RNA|CD101_ENST00000369470.1_Missense_Mutation_p.P946S|CD101_ENST00000467588.1_3'UTR	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	946					cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GCCCACGCTTCCTTCCAGGAT	0.463000													54	119					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14769802	14769802	+	Silent	SNP	T	T	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:14769802T>A	ENST00000380881.4	-	28	5942	c.5127A>T	c.(5125-5127)atA>atT	p.I1709I	FREM1_ENST00000422223.2_Silent_p.I1708I|FREM1_ENST00000380894.1_Silent_p.I244I|FREM1_ENST00000486223.1_5'UTR|FREM1_ENST00000380880.3_Silent_p.I1708I			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1708					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAGATGGGTTTATGATGTAAA	0.343000													18	6					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57666650	57666650	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:57666650G>A	ENST00000554048.2	-	5	528	c.529C>T	c.(529-531)Cct>Tct	p.P177S		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	177						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		AGTCCCTCAGGAATCTTGCCC	0.488000													35	50					0	0	1	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307644	39307644	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:39307644G>A	ENST00000541347.1	-	2	596	c.357C>T	c.(355-357)ttC>ttT	p.F119F	CX3CR1_ENST00000542107.1_Silent_p.F119F|CX3CR1_ENST00000358309.3_Silent_p.F151F|CX3CR1_ENST00000399220.2_Silent_p.F119F	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	119					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TGACGGTGATGAAGAATATGC	0.502000													55	94					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69796346	69796346	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:69796346C>T	ENST00000251566.4	-	5	1252	c.1222G>A	c.(1222-1224)Gga>Aga	p.G408R	UGT2A3_ENST00000420231.2_Missense_Mutation_p.G119R	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	408						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ACAGCTGCTCCTTTGGCCTTC	0.418000													67	118					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20566695	20566695	+	Silent	SNP	G	G	A	rs147574915		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:20566695G>A	ENST00000329697.6	-	4	660	c.492C>T	c.(490-492)atC>atT	p.I164I	ACSM2B_ENST00000567001.1_Silent_p.I164I|ACSM2B_ENST00000565322.1_Silent_p.I85I|ACSM2B_ENST00000414188.2_Silent_p.I164I|ACSM2B_ENST00000565232.1_Silent_p.I164I	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	164					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CCACTTCTTGGATGACTTCAT	0.453000													102	135					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2775010	2775010	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:2775010G>A	ENST00000380605.2	-	14	2095	c.2031C>T	c.(2029-2031)ggC>ggT	p.G677G		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	677					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CTGAATGGTAGCCCTCGGCAC	0.602000													41	49					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66458028	66458028	+	RNA	SNP	G	G	T	rs75630327		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:66458028G>T	ENST00000424345.1	+	0	67																											GGATCTTCAGGAGGAGGTCCT	0.701000													5	31					0.00307968	0.00308847	1	1	0
AZGP1	563	broad.mit.edu	37	7	99564732	99564732	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:99564732G>A	ENST00000292401.4	-	4	927	c.791C>T	c.(790-792)tCc>tTc	p.S264F	AZGP1_ENST00000483612.1_5'UTR|AZGP1_ENST00000411734.1_3'UTR	NM_001185.3	NP_001176.1	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	264	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CACCACCCAGGACTGGTAAGT	0.637000													23	68					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52812968	52812968	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:52812968G>A	ENST00000273283.2	+	4	340	c.316G>A	c.(316-318)Gga>Aga	p.G106R	ITIH1_ENST00000540715.1_5'UTR|ITIH1_ENST00000542827.1_Missense_Mutation_p.G106R	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	106	VIT.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TACAGCAGATGGAAACGCATT	0.537000													24	48					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159163739	159163739	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:159163739G>A	ENST00000368125.4	+	5	757	c.600G>A	c.(598-600)cgG>cgA	p.R200R	CADM3_ENST00000368124.4_Silent_p.R234R	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	200	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					AGGTTACCCGGGAGGATGATG	0.498000													29	66					0	0	1	0	0
MAP3K2	10746	broad.mit.edu	37	2	128083346	128083346	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:128083346G>A	ENST00000409947.1	-	9	917	c.635C>T	c.(634-636)tCt>tTt	p.S212F	MAP3K2_ENST00000344908.5_Missense_Mutation_p.S212F			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	212					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		TCCTGAGCCAGAATTTTCAGG	0.353000													41	53					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155127884	155127884	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:155127884G>A	ENST00000286448.6	+	4	478	c.313G>A	c.(313-315)Gag>Aag	p.E105K	VAMP7_ENST00000460621.1_Missense_Mutation_p.E64K|VAMP7_ENST00000262640.6_Missense_Mutation_p.E105K|VAMP7_ENST00000479687.1_3'UTR	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	105	Longin.				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CATGAATAGCGAGTTCTCAAG	0.393000													73	116					0	0	1	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186571052	186571052	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:186571052G>A	ENST00000412955.2	+	2	346	c.205G>A	c.(205-207)Gga>Aga	p.G69R	ADIPOQ_ENST00000444204.2_Missense_Mutation_p.G69R|ADIPOQ-AS1_ENST00000422718.1_RNA|ADIPOQ_ENST00000320741.2_Missense_Mutation_p.G69R			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	69	Collagen-like.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GGGTGAGAAAGGAGATCCAGG	0.517000													10	13					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197021838	197021838	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:197021838G>A	ENST00000367412.1	-	9	1524	c.1481C>T	c.(1480-1482)cCa>cTa	p.P494L		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	494	Sushi 8.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TGGGGTTAATGGAGATAAGTC	0.323000													67	58					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	67					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362514	105362514	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:105362514C>T	ENST00000369774.4	-	15	2737	c.2461G>A	c.(2461-2463)Gac>Aac	p.D821N	SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.D793N|SH3PXD2A_ENST00000427662.2_Intron|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.D688N|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.D656N			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	821					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GTGATGAGGTCGGATGAGCTT	0.632000													69	117					0	0	1	0	0
TMEM38A	79041	broad.mit.edu	37	19	16791328	16791328	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:16791328C>T	ENST00000187762.2	+	3	493	c.402C>T	c.(400-402)atC>atT	p.I134I		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	134						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						CGGTGGGCATCCATCACGCCC	0.527000													86	126					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108469041	108469041	+	Silent	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:108469041A>T	ENST00000263054.6	-	7	1090	c.1083T>A	c.(1081-1083)ccT>ccA	p.P361P	SORCS1_ENST00000344440.6_Silent_p.P361P	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	361						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGCCTGGAAAAGGCTGATTCC	0.403000													30	61					0	0	1	0	0
POP1	10940	broad.mit.edu	37	8	99142282	99142282	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:99142282G>A	ENST00000401707.2	+	5	644	c.563G>A	c.(562-564)cGg>cAg	p.R188Q	POP1_ENST00000349693.3_Missense_Mutation_p.R188Q	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	188					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CACATGAACCGGACGCTAGAA	0.418000													63	71					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237272514	237272514	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:237272514C>T	ENST00000409907.3	-	15	2052	c.1778G>A	c.(1777-1779)gGa>gAa	p.G593E	IQCA1_ENST00000309507.5_Missense_Mutation_p.G590E|IQCA1_ENST00000431676.2_Missense_Mutation_p.G552E			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	593							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						GAGGTTGGCTCCCGTTTCGGT	0.507000													50	93					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44683986	44683986	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:44683986A>G	ENST00000396058.1	+	5	1531	c.1364A>G	c.(1363-1365)aAg>aGg	p.K455R	ZNF197_ENST00000344387.4_Missense_Mutation_p.K455R|RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000383744.4_Intron			O14709	ZN197_HUMAN	zinc finger protein 197	455					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AAACCTTATAAGTGTAAGGAG	0.428000													54	77					0	0	1	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010864	59010864	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:59010864G>A	ENST00000263093.2	-	7	1771	c.1662C>T	c.(1660-1662)acC>acT	p.T554T	SLC27A5_ENST00000601355.1_Silent_p.T470T	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	554					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity	p.T554I(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CGGACCGGAAGGTGTCCCCGA	0.657000													29	36					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526069	176526069	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:176526069G>A	ENST00000367662.3	+	2	1775	c.611G>A	c.(610-612)aGg>aAg	p.R204K	PAPPA2_ENST00000367661.3_Missense_Mutation_p.R204K	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	204					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTGTGGAAGAGGCGGGCGGAA	0.562000													137	98					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103148803	103148803	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:103148803G>A	ENST00000295269.4	+	12	2510	c.2053G>A	c.(2053-2055)Gat>Aat	p.D685N		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	685					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TGACAGCAGTGATCCAGGATC	0.453000													41	62					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52941670	52941670	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:52941670C>T	ENST00000332323.6	+	4	1057	c.996C>T	c.(994-996)atC>atT	p.I332I	ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Silent_p.I319I|ZNF534_ENST00000301085.4_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						ATCTTGTAATCCATACTGGAG	0.418000													12	25					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158057667	158057667	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:158057667G>A	ENST00000264428.4	+	5	614	c.344G>A	c.(343-345)aGg>aAg	p.R115K	GLRB_ENST00000509282.1_Missense_Mutation_p.R115K|GLRB_ENST00000541722.1_Missense_Mutation_p.R115K|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	115					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	AATGACCCCAGGCTGAAGCTC	0.378000													34	51					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584363	30584363	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:30584363G>A	ENST00000217299.3	+	3	1017	c.843G>A	c.(841-843)caG>caA	p.Q281Q		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	281						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CCTCCTACCAGAAGGTGCTGC	0.711000													26	19					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157739827	157739827	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:157739827G>A	ENST00000361516.3	-	4	472	c.424C>T	c.(424-426)Cag>Tag	p.Q142*	FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000392274.3_Nonsense_Mutation_p.Q142*	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	142	Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AAGCAGAACTGGAGTTGAACA	0.567000													62	61					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124336154	124336154	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:124336154G>A	ENST00000368909.3	+	7	629	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	DMBT1_ENST00000368956.2_Missense_Mutation_p.E175K|DMBT1_ENST00000368955.3_Missense_Mutation_p.E175K|DMBT1_ENST00000338354.3_Missense_Mutation_p.E175K|DMBT1_ENST00000330163.4_Missense_Mutation_p.E175K|DMBT1_ENST00000344338.3_Missense_Mutation_p.E175K|DMBT1_ENST00000359586.6_Missense_Mutation_p.E175K	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	175	SRCR 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCAGGACACGAATCCTACCT	0.582000													61	126					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13769246	13769246	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:13769246C>T	ENST00000265104.4	-	58	9825		c.e58-1		DNAH5_ENST00000504001.3_Splice_Site	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTTTTAAGACCTAATTCAATA	0.413000									Kartagener syndrome				88	134					0	0	1	0	0
KCNG3	170850	broad.mit.edu	37	2	42671136	42671136	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:42671136G>A	ENST00000306078.1	-	2	1844	c.1249C>T	c.(1249-1251)Cat>Tat	p.H417Y	KCNG3_ENST00000394973.4_Missense_Mutation_p.H406Y	NM_133329.5|NM_172344.2	NP_579875.1|NP_758847.1	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G, member 3	417						endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	6						TTGAGCTCATGATAACACTGC	0.383000													55	79					0	0	1	0	0
DAZL	1618	broad.mit.edu	37	3	16633647	16633647	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:16633647C>T	ENST00000250863.8	-	10	1091	c.804G>A	c.(802-804)gtG>gtA	p.V268V	DAZL_ENST00000399444.2_Silent_p.V248V	NM_001190811.1	NP_001177740.1	Q92904	DAZL_HUMAN	deleted in azoospermia-like	248					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity		RAF1/DAZL(2)	endometrium(1)|large_intestine(3)|lung(4)|prostate(3)	11						TGCTTCGGTCCACAGATTTCT	0.343000													52	127					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73590889	73590889	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:73590889C>T	ENST00000339362.5	+	28	4549	c.4102C>T	c.(4102-4104)Ccg>Tcg	p.P1368S	NEO1_ENST00000261908.6_Missense_Mutation_p.P1368S|NEO1_ENST00000560262.1_Missense_Mutation_p.P1315S|NEO1_ENST00000558964.1_Missense_Mutation_p.P1357S			Q92859	NEO1_HUMAN	neogenin 1	1368					axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						GCCAGCAATCCCGCCTCCAGG	0.582000													52	56					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2211778	2211778	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:2211778C>T	ENST00000398665.3	+	16	1530	c.1494C>T	c.(1492-1494)ttC>ttT	p.F498F		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	498						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGCAGTTCCTGGCATACA	0.607000													4	5					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10426900	10426900	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:10426900G>A	ENST00000245503.5	-	37	5769	c.5385C>T	c.(5383-5385)acC>acT	p.T1795T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Silent_p.T1795T|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1795					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.T1795T(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GATCCTTCACGGTCTGCTCCA	0.567000													73	113					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73822656	73822656	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:73822656G>A	ENST00000373109.2	-	11	1581	c.1137C>T	c.(1135-1137)atC>atT	p.I379I	SPOCK2_ENST00000536168.1_Silent_p.I379I|SPOCK2_ENST00000317376.4_Silent_p.I379I	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	379					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						AGAAGCCCACGATGTCATCTG	0.672000													6	16					0	0	1	0	0
TACR1	6869	broad.mit.edu	37	2	75425860	75425860	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:75425860C>T	ENST00000305249.4	-	1	966	c.201G>A	c.(199-201)acG>acA	p.T67T	TACR1_ENST00000409848.3_Silent_p.T67T	NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1	67					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	GAAAATAGTTCGTCACTGTCC	0.512000													34	29					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053349	133053349	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:133053349G>A	ENST00000262283.5	-	9	1086	c.987C>T	c.(985-987)ctC>ctT	p.L329L	OC90_ENST00000603859.1_Silent_p.L133L|OC90_ENST00000443356.2_Silent_p.L133L|OC90_ENST00000254627.3_Silent_p.L133L			Q02509	OC90_HUMAN	otoconin 90	133	Phospholipase A2-like 2.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CGGGGTCTTGGAGACAGTCCA	0.572000													59	195					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367267	107367267	+	Silent	SNP	G	G	A	rs148835250	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:107367267G>A	ENST00000542196.1	-	1	684	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						AAGAGACAATGATTAATAACA	0.433000													53	107					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5860039	5860039	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:5860039G>A	ENST00000327087.8	-	11	1212	c.1141C>T	c.(1141-1143)Ctt>Ttt	p.L381F	ANO2_ENST00000356134.5_Missense_Mutation_p.L382F|ANO2_ENST00000546188.1_Missense_Mutation_p.L382F			Q9NQ90	ANO2_HUMAN	anoctamin 2	386						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CATCCATAAAGAAACACAATC	0.353000													12	15					0	0	1	0	0
EBNA1BP2	10969	broad.mit.edu	37	1	43630414	43630414	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:43630414G>A	ENST00000431635.2	-	9	1083	c.935C>T	c.(934-936)tCa>tTa	p.S312L	EBNA1BP2_ENST00000236051.2_Missense_Mutation_p.S257L	NM_001159936.1	NP_001153408.1	Q99848	EBP2_HUMAN	EBNA1 binding protein 2	257					ribosome biogenesis	membrane fraction|nucleolus	protein binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)	16	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GTTCCACTTTGAGCCTTTCTT	0.483000													39	98					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55449588	55449588	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:55449588C>T	ENST00000588756.1	-	7	2439	c.1953G>A	c.(1951-1953)ccG>ccA	p.P651P	NLRP7_ENST00000340844.2_Silent_p.P651P|NLRP7_ENST00000328092.5_Intron|NLRP7_ENST00000592784.1_Silent_p.P651P|NLRP7_ENST00000590030.1_Silent_p.P651P|NLRP7_ENST00000448121.2_Intron|NLRP7_ENST00000446217.1_Silent_p.P679P			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	651			P -> S (in HYDM).				ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GAGCCCAGTTCGGAATGGTTA	0.488000													41	80					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618097	77618097	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:77618097G>T	ENST00000521891.2	+	2	2222	c.1774G>T	c.(1774-1776)Ggc>Tgc	p.G592C	ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G592C|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G592C|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G592C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	592						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCACCAGCATGGCTTTACCCC	0.582000										HNSCC(33;0.089)			44	59					4.06502e-11	4.10003e-11	1	1	0
SORCS3	22986	broad.mit.edu	37	10	106960878	106960878	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:106960878G>A	ENST00000369701.3	+	16	2355	c.2127_splice	c.e16-1	p.G710_splice	SORCS3_ENST00000369699.4_5'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	710						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCTCTCTAAGGGAGAGCCTTG	0.443000													31	50					0	0	1	0	0
TSPAN2	10100	broad.mit.edu	37	1	115600211	115600211	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:115600211C>T	ENST00000369516.2	-	6	494	c.463G>A	c.(463-465)Gaa>Aaa	p.E155K	TSPAN2_ENST00000369515.2_Missense_Mutation_p.E130K|TSPAN2_ENST00000369514.2_Missense_Mutation_p.E155K|TSPAN2_ENST00000491992.1_5'UTR	NM_005725.4	NP_005716.2	O60636	TSN2_HUMAN	tetraspanin 2	155						integral to membrane				central_nervous_system(1)|large_intestine(4)|lung(3)|pancreas(1)|prostate(1)	10	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		TCGGAGCTTTCTTTTCCACAG	0.502000													162	141					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723453	58723453	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:58723453G>A	ENST00000300079.5	+	7	1005	c.955G>A	c.(955-957)Gag>Aag	p.E319K	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Missense_Mutation_p.E288K	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	288						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	GGCCTCCTGTGAGTGGCACCA	0.428000													43	62					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60802380	60802380	+	Missense_Mutation	SNP	C	C	T	rs147565657		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:60802380C>T	ENST00000544856.2	-	8	2398	c.2020G>A	c.(2020-2022)Gag>Aag	p.E674K	RP11-156L14.1_ENST00000579201.1_RNA|MARCH10_ENST00000583600.1_Missense_Mutation_p.E713K|MARCH10_ENST00000311269.5_Missense_Mutation_p.E675K|RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.E675K|RP11-156L14.1_ENST00000584597.1_RNA|RP11-156L14.1_ENST00000577270.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	675							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						CCGCAAGGCTCCAGGAGGGGG	0.532000													47	86					0	0	1	0	0
CCDC115	84317	broad.mit.edu	37	2	131099446	131099446	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:131099446G>A	ENST00000259229.2	-	2	406	c.183C>T	c.(181-183)tcC>tcT	p.S61S	CCDC115_ENST00000409127.1_Silent_p.S56S|CCDC115_ENST00000437688.2_Silent_p.S56S	NM_032357.2	NP_115733.2	Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	61						endosome|lysosome				central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	7	Colorectal(110;0.1)					GCTCCATGTGGGAAGCATACT	0.677000													18	26					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177249810	177249810	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:177249810G>A	ENST00000361539.4	+	8	1810	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		500						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CGAGTCCCTGGAAAACTTTCT	0.587000													18	67					0	0	1	0	0
DRGX	644168	broad.mit.edu	37	10	50594795	50594795	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:50594795C>T	ENST00000374139.2	-	4	354	c.344G>A	c.(343-345)aGa>aAa	p.R115K	DRGX_ENST00000434016.1_Missense_Mutation_p.R120K			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	120					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						GTTGATGTTTCTCACTGGAGG	0.642000													54	76					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760805	62760805	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:62760805G>A	ENST00000336232.2	-	11	1668	c.1533C>T	c.(1531-1533)tcC>tcT	p.S511S	SLC22A8_ENST00000535878.1_Silent_p.S388S|SLC22A8_ENST00000430500.2_Silent_p.S511S|SLC22A8_ENST00000545207.1_Silent_p.S420S|SLC22A8_ENST00000311438.8_3'UTR	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	511					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						TTGCCCGCAGGGACCTAGGGA	0.617000													17	31					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768675	57768675	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:57768675G>A	ENST00000371030.2	+	1	2601	c.2601G>A	c.(2599-2601)ggG>ggA	p.G867G		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	867						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AGGTGCCAGGGGGCTCAAAGG	0.657000													27	51					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169351717	169351717	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:169351717G>A	ENST00000511577.1	-	13	1836	c.1589C>T	c.(1588-1590)tCg>tTg	p.S530L	DDX60L_ENST00000260184.7_Missense_Mutation_p.S530L|DDX60L_ENST00000505890.1_Missense_Mutation_p.S530L			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	530							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TGATTCTAACGATTTCCCATA	0.368000													10	12					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97311558	97311558	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:97311558C>T	ENST00000389672.5	+	12	2527	c.2489C>T	c.(2488-2490)tCt>tTt	p.S830F	EPHA6_ENST00000502694.1_Missense_Mutation_p.S222F|EPHA6_ENST00000442602.2_Missense_Mutation_p.S196F|EPHA6_ENST00000514100.1_Missense_Mutation_p.S222F	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	735	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GGGGGAGGATCTTTGCCCCCC	0.542000													24	28					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31138999	31138999	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:31138999G>A	ENST00000538351.1	-	7	942	c.188C>T	c.(187-189)tCc>tTc	p.S63F	ZNF438_ENST00000436087.2_Missense_Mutation_p.S112F|ZNF438_ENST00000452305.1_Missense_Mutation_p.S102F|ZNF438_ENST00000375311.1_Intron|ZNF438_ENST00000442986.1_Missense_Mutation_p.S112F|ZNF438_ENST00000331737.6_Missense_Mutation_p.S102F|ZNF438_ENST00000361310.3_Missense_Mutation_p.S112F|ZNF438_ENST00000444692.2_Missense_Mutation_p.S102F|ZNF438_ENST00000413025.1_Missense_Mutation_p.S112F	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TTCAGGTAGGGACATTCTGGG	0.468000													58	116					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553020	140553020	+	Missense_Mutation	SNP	C	C	T	rs113945814		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:140553020C>T	ENST00000231137.3	+	1	778	c.604C>T	c.(604-606)Cgg>Tgg	p.R202W		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		202	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTGCTGGATCGGGAAGAGAT	0.507000													40	57					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79350694	79350694	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:79350694G>A	ENST00000419573.3	-	3	787	c.513C>T	c.(511-513)atC>atT	p.I171I	RASGRF1_ENST00000558480.2_Silent_p.I171I|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	171					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TCAGCCGCTCGATCTCGATCT	0.602000													71	90					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116304847	116304847	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:116304847G>A	ENST00000533213.2	-	6	932	c.631C>T	c.(631-633)Ccg>Tcg	p.P211S	ABLIM1_ENST00000277895.5_Missense_Mutation_p.P271S|ABLIM1_ENST00000369252.4_Missense_Mutation_p.P211S			O14639	ABLM1_HUMAN	actin binding LIM protein 1	271	LIM zinc-binding 2.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TCACAGTACGGAGCACCATCC	0.542000													69	91					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58366007	58366007	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:58366007G>A	ENST00000300896.4	-	5	642	c.448C>T	c.(448-450)Ctt>Ttt	p.L150F	USP32_ENST00000393003.3_Missense_Mutation_p.L150F	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	150					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TTTAGAAAAAGCCAATTTCTA	0.333000													28	52					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169639033	169639033	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:169639033G>A	ENST00000428432.2	+	4	507	c.118G>A	c.(118-120)Gac>Aac	p.D40N	SAMD7_ENST00000335556.3_Missense_Mutation_p.D40N	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	40										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGCTCCAACTGACCCAAGACA	0.413000													86	124					0	0	1	0	0
YJEFN3	374887	broad.mit.edu	37	19	19645861	19645861	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:19645861C>T	ENST00000555938.1	+	5	346	c.334C>T	c.(334-336)Ctc>Ttc	p.L112F	YJEFN3_ENST00000436027.4_Missense_Mutation_p.L63F|YJEFN3_ENST00000514277.3_Missense_Mutation_p.L113F																							GTTGCCCGCTCTCTCCCGGAA	0.642000													82	121					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45254578	45254578	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:45254578G>A	ENST00000164227.5	+	2	595	c.351G>A	c.(349-351)atG>atA	p.M117I		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	117	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				TGTGCCCCATGGAACACCCCC	0.597000			T	IGH@	CLL								48	96					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	60					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75101981	75101981	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:75101981C>T	ENST00000326665.5	-	6	804	c.586G>A	c.(586-588)Gct>Act	p.A196T		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	196										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGAAACAGAGCTTCATTTTCC	0.328000													72	131					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152129199	152129199	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:152129199C>T	ENST00000316073.3	-	3	440	c.376G>A	c.(376-378)Gag>Aag	p.E126K		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	126	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTTTCTTCCTCGTGCCTCTGT	0.547000													134	338					0	0	1	0	0
THAP4	51078	broad.mit.edu	37	2	242545739	242545739	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:242545739G>A	ENST00000407315.1	-	3	1821	c.1390C>T	c.(1390-1392)Ctg>Ttg	p.L464L	THAP4_ENST00000402136.1_Silent_p.L52L|THAP4_ENST00000402545.1_Silent_p.L52L	NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	464							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		GAGAAGTTCAGCATGGGCTGG	0.582000													6	5					0	0	1	0	0
GTSF1L	149699	broad.mit.edu	37	20	42354906	42354906	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:42354906G>A	ENST00000373003.1	-	1	732	c.429C>T	c.(427-429)atC>atT	p.I143I	GTSF1L_ENST00000373005.2_Silent_p.I118I	NM_001008901.1|NM_176791.3	NP_001008901.1|NP_789761.1	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like	143							metal ion binding			endometrium(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CTGGTCTGAGGATCTTCTGGG	0.443000													46	82					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398778	89398778	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:89398778G>A	ENST00000439576.2	+	12	3336	c.2962G>A	c.(2962-2964)Gga>Aga	p.G988R	ACAN_ENST00000561243.1_Missense_Mutation_p.G988R|ACAN_ENST00000559004.1_Missense_Mutation_p.G988R|ACAN_ENST00000352105.7_Missense_Mutation_p.G988R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	988					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CACTGCCCCTGGAGTAGAGGA	0.542000													74	137					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803700	185803700	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:185803700C>T	ENST00000302277.6	+	4	4171	c.3577C>T	c.(3577-3579)Cct>Tct	p.P1193S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1193						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGCACTCTTTCCTTCACTGCT	0.453000													112	208					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140057149	140057149	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:140057149G>A	ENST00000371561.3	+	14	3068	c.1971G>A	c.(1969-1971)ctG>ctA	p.L657L	GRIN1_ENST00000315048.3_Silent_p.L657L|GRIN1_ENST00000371550.4_Silent_p.L657L|GRIN1_ENST00000371560.3_Silent_p.L678L|GRIN1_ENST00000371555.4_Silent_p.L678L|GRIN1_ENST00000371559.4_Silent_p.L657L|GRIN1_ENST00000371546.4_Silent_p.L678L|GRIN1_ENST00000371553.3_Silent_p.L678L|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000350902.5_Silent_p.L657L	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	657					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TCCTGGTGCTGGACCGGCCGG	0.682000													4	19					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54912996	54912996	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:54912996C>A	ENST00000293373.6	+	16	1584	c.1505C>A	c.(1504-1506)cCt>cAt	p.P502H	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.P452H	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	502					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GCTAAGGCCCCTCTGCACCTG	0.488000													46	79					1.61004e-24	1.63171e-24	1	1	0
EHMT1	79813	broad.mit.edu	37	9	140710440	140710440	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:140710440C>T	ENST00000460843.1	+	23	3327	c.3300C>T	c.(3298-3300)ccC>ccT	p.P1100P		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1100	Pre-SET.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CGGAGCCTCCCTTGATCTTCG	0.572000													11	21					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34182070	34182070	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:34182070C>T	ENST00000373381.4	-	20	3209	c.3033G>A	c.(3031-3033)ctG>ctA	p.L1011L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	971	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCCACTTTCCAGGTGGAAGG	0.572000													15	23					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	119999149	119999149	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:119999149C>T	ENST00000341846.5	-	2	1280	c.859G>A	c.(859-861)Gat>Aat	p.D287N	TRIM29_ENST00000541857.1_Missense_Mutation_p.D20N|TRIM29_ENST00000529044.1_Missense_Mutation_p.D26N	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	287					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		TCAGCTTCATCCTCAATCTCA	0.557000													22	36					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43527965	43527965	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:43527965G>A	ENST00000220420.5	-	10	1423	c.1416C>T	c.(1414-1416)tcC>tcT	p.S472S	TGM5_ENST00000349114.4_Silent_p.S390S	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	472					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CTCCTCTTTGGGAGCCATGGA	0.582000													44	84					0	0	1	0	0
UBE4A	9354	broad.mit.edu	37	11	118245918	118245918	+	Missense_Mutation	SNP	G	G	A	rs145336832	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:118245918G>A	ENST00000252108.3	+	9	1555	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q	UBE4A_ENST00000431736.2_Missense_Mutation_p.R482Q	NM_001204077.1|NM_004788.3	NP_001191006.1|NP_004779.2	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	475					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(7)|liver(2)|lung(14)|ovary(3)|prostate(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	56	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GATGAAGAACGAAAAATTAAA	0.448000													20	34					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113479850	113479850	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:113479850C>T	ENST00000487903.1	+	11	1067	c.979C>T	c.(979-981)Ccg>Tcg	p.P327S	ATP11A_ENST00000283558.8_Missense_Mutation_p.P327S|ATP11A_ENST00000375645.3_Missense_Mutation_p.P327S|ATP11A_ENST00000375630.2_Missense_Mutation_p.P327S			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	327					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCGGGATGAGCCGTGGTATAA	0.483000													25	46					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	769331	769331	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:769331C>T	ENST00000297440.6	+	2	647	c.627C>T	c.(625-627)atC>atT	p.I209I	HEATR2_ENST00000313147.5_Silent_p.I209I|HEATR2_ENST00000438961.1_3'UTR	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	209							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		AGTCTCTGATCGGGCCCCTGA	0.627000													17	47					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50041130	50041130	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:50041130C>T	ENST00000335154.5	-	24	3033	c.2800G>A	c.(2800-2802)Gcc>Acc	p.A934T	FMNL3_ENST00000550488.1_Missense_Mutation_p.A933T|FMNL3_ENST00000293590.5_Missense_Mutation_p.A934T|FMNL3_ENST00000352151.5_Missense_Mutation_p.A883T	NM_175736.4	NP_783863.4	Q8IVF7	FMNL3_HUMAN	formin-like 3	934	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						TTCTTGCGGGCTTCATTCTCT	0.587000													50	83					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23811825	23811825	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:23811825C>T	ENST00000354639.3	+	15	2288	c.1824C>T	c.(1822-1824)tcC>tcT	p.S608S	STK31_ENST00000428484.1_Silent_p.S608S|STK31_ENST00000355870.3_Silent_p.S631S|STK31_ENST00000433467.2_Silent_p.S631S|STK31_ENST00000405627.3_3'UTR	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	631							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						ACTTGCTATCCATTAAGAAGA	0.313000													28	58					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41352930	41352930	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:41352930G>A	ENST00000551295.2	+	15	1815	c.1698G>A	c.(1696-1698)ggG>ggA	p.G566G	CNTN1_ENST00000348761.2_Silent_p.G555G|CNTN1_ENST00000347616.1_Silent_p.G566G|CNTN1_ENST00000360099.3_Silent_p.G566G|CNTN1_ENST00000547849.1_Silent_p.G566G|CNTN1_ENST00000547702.1_Silent_p.G566G	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	566	Ig-like C2-type 6.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				ATTCCAATGGGGAATTACTAA	0.408000													28	44					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4856063	4856063	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:4856063A>C	ENST00000399583.3	-	8	1949	c.1762T>G	c.(1762-1764)Tgc>Ggc	p.C588G	RADIL_ENST00000538469.1_Missense_Mutation_p.C348G|RADIL_ENST00000536091.1_Missense_Mutation_p.V534G	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	588	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		AATGGCGGGCACTCCAGGAGT	0.687000													4	14					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471587	61471587	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:61471587G>A	ENST00000398019.2	+	8	1186	c.861G>A	c.(859-861)atG>atA	p.M287I	SERPINB7_ENST00000546027.1_Missense_Mutation_p.M287I|SERPINB7_ENST00000336429.2_Missense_Mutation_p.M287I|SERPINB7_ENST00000540675.1_Missense_Mutation_p.M270I	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	287					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				ATTATGAAATGAAACAATATT	0.398000													25	58					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369098	86369098	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:86369098C>T	ENST00000400286.2	-	2	2144	c.1546G>A	c.(1546-1548)Gat>Aat	p.D516N		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	516						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CAGGGGTTATCCTCAAGGTCA	0.428000													49	60					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19861716	19861716	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:19861716G>A	ENST00000225737.6	-	4	645	c.488C>T	c.(487-489)tCa>tTa	p.S163L	AKAP10_ENST00000572155.1_5'UTR|AKAP10_ENST00000395536.3_Missense_Mutation_p.S163L	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	163	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CCAAGTTGTTGAATGAAAACT	0.438000													48	63					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42543112	42543112	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:42543112C>T	ENST00000318522.5	+	18	2240	c.1978C>T	c.(1978-1980)Ctg>Ttg	p.L660L	EML4_ENST00000453191.2_Intron|EML4_ENST00000402711.2_Silent_p.L602L|EML4_ENST00000401738.3_Silent_p.L671L	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	660					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						GTGGTTTGTTCTGGATGCAGA	0.353000			T	ALK	NSCLC								46	77					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49390574	49390574	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:49390574G>A	ENST00000421952.2	-	2	2106	c.2085C>T	c.(2083-2085)ttC>ttT	p.F695F		NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	695	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						CCCTCACCCCGAAGAGGACCT	0.547000											OREG0021778	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	65					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38905946	38905946	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:38905946C>T	ENST00000359357.3	+	76	11363	c.11109C>T	c.(11107-11109)atC>atT	p.I3703I	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000441566.1_Silent_p.I3667I|DNAH8_ENST00000449981.2_Silent_p.I3920I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGGTCAACATCATGTATCAGA	0.507000													39	23					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64679780	64679780	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:64679780C>T	ENST00000543942.2	-	7	1800	c.1174G>A	c.(1174-1176)Gat>Aat	p.D392N	C12orf56_ENST00000536975.1_5'UTR|RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000333722.5_Missense_Mutation_p.D232N	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	395										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		GCATTCTTATCCCTAGACTCC	0.353000													16	31					0	0	1	0	0
CCDC57	284001	broad.mit.edu	37	17	80151677	80151677	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:80151677G>A	ENST00000389641.4	-	6	842	c.806C>T	c.(805-807)tCt>tTt	p.S269F	CCDC57_ENST00000392343.3_Missense_Mutation_p.S269F|CCDC57_ENST00000392347.1_Missense_Mutation_p.S269F			Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	269										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TAGCTGCACAGAGTGAAGTTT	0.448000													3	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179649069	179649069	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:179649069C>T	ENST00000589042.1	-	16	2727	c.2503G>A	c.(2503-2505)Gcc>Acc	p.A835T	TTN_ENST00000359218.5_Missense_Mutation_p.A789T|TTN_ENST00000591111.1_Missense_Mutation_p.A835T|TTN_ENST00000342992.6_Missense_Mutation_p.A835T|TTN_ENST00000460472.2_Missense_Mutation_p.A789T|TTN_ENST00000360870.5_Missense_Mutation_p.A835T|TTN_ENST00000342175.6_Missense_Mutation_p.A789T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	835							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACTACCGGCTATTGATGCC	0.448000													36	59					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8018372	8018372	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:8018372C>T	ENST00000380149.1	-	4	936	c.906G>A	c.(904-906)tgG>tgA	p.W302*	ALOXE3_ENST00000318227.3_Nonsense_Mutation_p.W278*|ALOXE3_ENST00000448843.2_Nonsense_Mutation_p.W146*			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	146	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						CATAGATCTTCCAGCTTCCGA	0.473000													61	121					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	419601	419601	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:419601G>A	ENST00000256509.2	+	16	2494	c.1852G>A	c.(1852-1854)Gat>Aat	p.D618N	CHL1_ENST00000397491.2_Missense_Mutation_p.D602N|CHL1-AS1_ENST00000417612.1_RNA	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	602	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAGTGCTGCCGATATAACTCA	0.368000													44	85					0	0	1	0	0
CHRDL1	91851	broad.mit.edu	37	X	109931888	109931888	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:109931888G>A	ENST00000218054.4	-	9	1115	c.919C>T	c.(919-921)Ccc>Tcc	p.P307S	CHRDL1_ENST00000482160.1_Missense_Mutation_p.P228S|CHRDL1_ENST00000372042.1_Missense_Mutation_p.P308S|CHRDL1_ENST00000434224.1_Missense_Mutation_p.P228S|CHRDL1_ENST00000394797.4_Missense_Mutation_p.P307S|CHRDL1_ENST00000372045.1_Missense_Mutation_p.P301S|CHRDL1_ENST00000444321.2_Missense_Mutation_p.P307S	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	301	VWFC 3.				BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TACTTGCAGGGGTATCGATTG	0.473000													89	32					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124438107	124438107	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:124438107G>A	ENST00000360013.3	+	60	8878	c.8751G>A	c.(8749-8751)gtG>gtA	p.V2917V	KALRN_ENST00000291478.4_Silent_p.V1220V|KALRN_ENST00000428018.2_Silent_p.V1188V	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2916	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TCATCAATGTGATCTTACAGG	0.512000													27	62					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66458014	66458014	+	RNA	SNP	T	T	C	rs75891239	by1000genomes	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:66458014T>C	ENST00000424345.1	+	0	67																											GGTGCTGCAGTGGCGGATCTT	0.721000													5	32					0	0	1	0	0
SASH3	54440	broad.mit.edu	37	X	128926407	128926407	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:128926407C>T	ENST00000356892.3	+	5	660	c.546C>T	c.(544-546)acC>acT	p.T182T		NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	182	SH3.									breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						GAGTCCACACCGACTTCACTC	0.622000													101	41					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108172972	108172972	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:108172972C>T	ENST00000273353.3	-	22	2396	c.2340G>A	c.(2338-2340)ggG>ggA	p.G780G		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	780	Actin-binding (By similarity).|Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GGCCCAGAAACCCAGCTTTAA	0.403000													33	55					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101794106	101794106	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:101794106C>T	ENST00000506729.1	-	6	1282	c.1111G>A	c.(1111-1113)Gat>Aat	p.D371N	SLCO6A1_ENST00000379807.3_Missense_Mutation_p.D371N|SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000513675.1_Intron|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.D309N|SLCO6A1_ENST00000379810.1_Intron			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	371						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GCACATAAATCCTTGATATTA	0.303000													41	93					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100928738	100928738	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:100928738C>T	ENST00000548884.1	+	6	1198	c.657C>T	c.(655-657)acC>acT	p.T219T	NR1H4_ENST00000188403.7_Silent_p.T229T|NR1H4_ENST00000551379.1_Silent_p.T233T|NR1H4_ENST00000392986.3_Silent_p.T223T|NR1H4_ENST00000549996.1_Silent_p.T172T	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	233					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.T219T(3)|p.T233T(2)		NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						CAGATCAGACCGTGAATGAAG	0.428000													31	61					0	0	1	0	0
INTS6-AS1	100507398	broad.mit.edu	37	13	52035444	52035444	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:52035444G>A	ENST00000594959.1	+	0	411				INTS6-AS1_ENST00000593709.1_RNA|INTS6-AS1_ENST00000599315.1_RNA|INTS6-AS1_ENST00000598864.1_RNA|INTS6-AS1_ENST00000601572.1_RNA|INTS6-AS1_ENST00000594358.1_RNA|INTS6-AS1_ENST00000594488.1_RNA|INTS6-AS1_ENST00000597745.1_RNA|INTS6-AS1_ENST00000596303.1_RNA|INTS6-AS1_ENST00000434512.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000594604.1_RNA|INTS6-AS1_ENST00000595997.1_RNA|INTS6-AS1_ENST00000602089.1_RNA|INTS6-AS1_ENST00000593429.1_RNA|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000596180.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000601318.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|INTS6-AS1_ENST00000601034.1_RNA|RPS4XP16_ENST00000595905.1_RNA|INTS6-AS1_ENST00000593928.1_RNA|INTS6-AS1_ENST00000600477.1_RNA																							ACAGAGCAGTGGGTGAAATGG	0.403000													9	19					0	0	1	0	0
HOXD10	3236	broad.mit.edu	37	2	176981927	176981927	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:176981927A>T	ENST00000249501.4	+	1	621	c.366A>T	c.(364-366)aaA>aaT	p.K122N	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	122						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		AGCGCAACAAACTCATTTCGG	0.498000													82	120					0	0	1	0	0
KCNJ10	3766	broad.mit.edu	37	1	160011957	160011957	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:160011957G>A	ENST00000368089.3	-	2	592	c.366C>T	c.(364-366)tcC>tcT	p.S122S	KCNJ10_ENST00000509700.1_5'UTR	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	122						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGATTCAAGGGAGAAGAGGA	0.577000													108	78					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951997	119951997	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:119951997G>A	ENST00000307142.4	+	4	2263	c.2067G>A	c.(2065-2067)agG>agA	p.R689R	SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Silent_p.R689R|SYNPO2_ENST00000429713.2_Silent_p.R689R	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	689						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						AGGCCAAAAGGAGAAGCACGA	0.468000													19	58					0	0	1	0	0
SRGAP2	23380	broad.mit.edu	37	1	206613347	206613347	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:206613347G>A	ENST00000414007.1	+	13	1370	c.1370G>A	c.(1369-1371)aGa>aAa	p.R457K	SRGAP2_ENST00000419187.2_5'UTR			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	597					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					CTGCAGGAGAGAGCTCTGCAC	0.483000													17	58					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79980482	79980482	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:79980482A>T	ENST00000373275.4	-	15	1687	c.1471T>A	c.(1471-1473)Ttt>Att	p.F491I		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	491										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TCCCAAATAAAAATGTTCCCA	0.383000													37	14					0	0	1	0	0
RBM27	54439	broad.mit.edu	37	5	145610319	145610319	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:145610319C>T	ENST00000265271.5	+	6	855	c.689C>T	c.(688-690)tCc>tTc	p.S230F	RBM27_ENST00000506502.1_Missense_Mutation_p.S230F	NM_018989.1	NP_061862.1	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	230					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGCAGTATTCCTCTGGGGCA	0.463000													52	75					0	0	1	0	0
METTL14	57721	broad.mit.edu	37	4	119613142	119613142	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:119613142C>T	ENST00000388822.4	+	5	498	c.331C>T	c.(331-333)Cag>Tag	p.Q111*	METTL14_ENST00000506780.1_Nonsense_Mutation_p.Q73*			Q9HCE5	MTL14_HUMAN	methyltransferase like 14	111						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						TTAGGGAACACAGAGCTTAAA	0.328000													42	94					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110853802	110853802	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:110853802C>T	ENST00000375820.4	-	19	1188	c.1067G>A	c.(1066-1068)gGa>gAa	p.G356E	COL4A1_ENST00000543140.1_Missense_Mutation_p.G356E	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	356	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GCCTGGCTCTCCTCTTGGCCC	0.562000													25	47					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	98943539	98943539	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:98943539C>T	ENST00000254898.5	+	3	732	c.501C>T	c.(499-501)atC>atT	p.I167I	MATN2_ENST00000522025.2_Intron|MATN2_ENST00000520016.1_Silent_p.I167I|MATN2_ENST00000521689.1_Silent_p.I167I|MATN2_ENST00000524308.1_Silent_p.I167I	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	167	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding	p.I167I(2)		breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TCATAATGATCGTGACAGATG	0.597000													16	67					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45309861	45309861	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:45309861G>A	ENST00000313237.5	-	5	822	c.672C>T	c.(670-672)ccC>ccT	p.P224P	PHF21B_ENST00000404079.2_Intron|PHF21B_ENST00000403565.1_Intron|PHF21B_ENST00000396103.3_Intron|PHF21B_ENST00000447824.3_Intron	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	224							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		TGCCATggaggggtgaagggg	0.642000													53	65					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118506206	118506206	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:118506206C>T	ENST00000311085.8	+	24	5800	c.5720C>T	c.(5719-5721)tCt>tTt	p.S1907F	DMXL1_ENST00000539542.1_Missense_Mutation_p.S1907F	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1907										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TGTTCTCCTTCTTCTCCATTA	0.383000													59	99					0	0	1	0	0
DDX21	9188	broad.mit.edu	37	10	70730096	70730096	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:70730096C>T	ENST00000354185.4	+	8	1474	c.1376C>T	c.(1375-1377)gCt>gTt	p.A459V		NM_001256910.1|NM_004728.3	NP_001243839.1|NP_004719.2	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 21	459	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CAGAATTCAGCTATAAAGCAG	0.438000													17	25					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192280925	192280925	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:192280925C>T	ENST00000392318.3	+	30	3491	c.3244C>T	c.(3244-3246)Ctc>Ttc	p.L1082F	MYO1B_ENST00000439065.2_Missense_Mutation_p.L327F|MYO1B_ENST00000304164.4_Missense_Mutation_p.L1082F|MYO1B_ENST00000392316.1_Missense_Mutation_p.L1053F|MYO1B_ENST00000339514.4_Missense_Mutation_p.L1024F	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	1082						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TCGCACAACTCTCAGCCAAAC	0.413000													68	118					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43934182	43934182	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:43934182G>A	ENST00000261488.6	-	7	971	c.394C>T	c.(394-396)Cct>Tct	p.P132S	ENOX1_ENST00000482207.1_5'UTR|ENOX1_ENST00000412891.1_Missense_Mutation_p.P132S|ENOX1_ENST00000540032.1_5'UTR	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	132	Pro-rich.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CTTGTGGAAGGAGGTGGAAGA	0.393000													21	46					0	0	1	0	0
SCYL2	55681	broad.mit.edu	37	12	100717409	100717409	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:100717409C>T	ENST00000360820.2	+	11	1939	c.1502C>T	c.(1501-1503)tCc>tTc	p.S501F		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	501					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						CAAACATCTTCCCTTGCGGTA	0.299000													32	39					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4929509	4929509	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:4929509G>A	ENST00000359350.4	+	1	910	c.910G>A	c.(910-912)Ggg>Agg	p.G304R	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAAGATCTTGGGGAAGTTGCT	0.398000													39	69					0	0	1	0	0
ZNF385A	25946	broad.mit.edu	37	12	54765286	54765286	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:54765286G>A	ENST00000546970.1	-	6	864	c.575C>T	c.(574-576)tCc>tTc	p.S192F	RP11-753H16.5_ENST00000552785.1_RNA|ZNF385A_ENST00000394313.2_Missense_Mutation_p.S192F|ZNF385A_ENST00000551109.1_Missense_Mutation_p.S192F|ZNF385A_ENST00000551771.1_Intron|RP11-753H16.3_ENST00000550474.1_RNA|ZNF385A_ENST00000552382.1_5'UTR|ZNF385A_ENST00000352268.6_Intron|ZNF385A_ENST00000338010.5_Missense_Mutation_p.S212F			Q96PM9	Z385A_HUMAN	zinc finger protein 385A	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|urinary_tract(1)	15						CTGGGACAGGGAGTTCACAGC	0.607000													80	143					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28992812	28992812	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:28992812G>A	ENST00000359747.4	+	15	2463	c.2434G>A	c.(2434-2436)Gaa>Aaa	p.E812K	RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.E793K	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	793					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTATGCAGATGAAGATGAAGG	0.413000													45	62					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993488	140993488	+	Nonsense_Mutation	SNP	C	C	T	rs145052423		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:140993488C>T	ENST00000285879.4	+	4	584	c.298C>T	c.(298-300)Cag>Tag	p.Q100*	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	100							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGAATTCTCAGAGTTCTCC	0.572000										HNSCC(15;0.026)			100	36					0	0	1	0	0
C8orf22	492307	broad.mit.edu	37	8	49987797	49987797	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:49987797G>A	ENST00000399653.4	+	5	420	c.237G>A	c.(235-237)atG>atA	p.M79I	C8orf22_ENST00000303202.8_3'UTR|C8orf22_ENST00000522267.1_3'UTR|C8orf22_ENST00000517663.1_3'UTR	NM_001007176.4|NM_001256597.1	NP_001007177.1|NP_001243526.1	Q8WWR9	PDPFL_HUMAN	chromosome 8 open reading frame 22	0										large_intestine(1)|lung(7)|prostate(1)	9		all_cancers(86;0.0452)|all_epithelial(80;0.000863)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TATGTAGCATGAACAGTTGAT	0.463000													47	82					0	0	1	0	0
TIGD3	220359	broad.mit.edu	37	11	65124381	65124381	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:65124381G>A	ENST00000309880.5	+	2	1309	c.1102G>A	c.(1102-1104)Ggc>Agc	p.G368S		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	368					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						GCTGGCTCCCGGCAAAACGCC	0.632000													53	109					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182344910	182344910	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:182344910C>G	ENST00000397033.2	+	6	1101	c.671C>G	c.(670-672)tCt>tGt	p.S224C		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	224					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGGACTGGCTCTCTTTTTGTC	0.303000													31	53					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140640985	140640985	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:140640985C>T	ENST00000509479.2	-	5	3765	c.2909G>A	c.(2908-2910)gGc>gAc	p.G970D	MGST2_ENST00000515137.1_Intron	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	966					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					CCCAGGCATGCCCTGCAAGCT	0.597000													29	58					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38802765	38802765	+	Silent	SNP	G	G	A	rs149892218		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:38802765G>A	ENST00000449082.2	-	6	800	c.801C>T	c.(799-801)ctC>ctT	p.L267L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	267					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGCCCTTGAAGAGTTGCAGCC	0.468000													43	46					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44612295	44612295	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:44612295T>C	ENST00000273320.3	+	6	2122	c.1693T>C	c.(1693-1695)Tgt>Cgt	p.C565R	ZKSCAN7_ENST00000426540.1_Missense_Mutation_p.C565R|ZKSCAN7_ENST00000431636.1_Intron|RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000341840.3_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		TCGGAGTAAATGTCTTATTCG	0.428000													38	86					0	0	1	0	0
EZR	7430	broad.mit.edu	37	6	159205710	159205710	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:159205710G>A	ENST00000367075.3	-	6	685	c.517C>T	c.(517-519)Cag>Tag	p.Q173*	EZR_ENST00000392177.4_Nonsense_Mutation_p.Q141*|EZR_ENST00000476189.1_5'UTR|EZR_ENST00000337147.7_Nonsense_Mutation_p.Q173*	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	173	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TGCCACACCTGGATCCGGTCC	0.547000			T	ROS1	NSCLC								17	9					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28617510	28617510	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:28617510G>A	ENST00000395609.1	-	9	1400	c.642C>T	c.(640-642)tcC>tcT	p.S214S	SULT1A1_ENST00000569554.1_Silent_p.S214S|SULT1A1_ENST00000395607.1_Silent_p.S214S|SULT1A1_ENST00000350842.4_Silent_p.S136S|SULT1A1_ENST00000314752.7_Silent_p.S214S			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	214					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						CCTCTGGCAGGGAGCGCCCCA	0.547000													19	81					0	0	1	0	0
KERA	11081	broad.mit.edu	37	12	91449860	91449860	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:91449860G>A	ENST00000266719.3	-	2	446	c.199C>T	c.(199-201)Cct>Tct	p.P67S		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	67	LRRNT.				response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						GGAATAGCAGGAATTTCTTTG	0.388000													51	67					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564145	176564145	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:176564145C>T	ENST00000367662.3	+	3	2569	c.1405C>T	c.(1405-1407)Ccc>Tcc	p.P469S	PAPPA2_ENST00000367661.3_Missense_Mutation_p.P469S	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	469	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGAGTGGGTTCCCTTTAGAGA	0.537000													104	83					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327571	57327571	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:57327571C>T	ENST00000326441.9	-	10	2602	c.2239G>A	c.(2239-2241)Gaa>Aaa	p.E747K	PEG3_ENST00000593695.1_Missense_Mutation_p.E621K|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E747K|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E623K|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	747					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AACGCCTTTTCGTCCTCATCA	0.408000													97	149					0	0	1	0	0
CNTD2	79935	broad.mit.edu	37	19	40732319	40732319	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:40732319T>C	ENST00000430325.2	-	1	278	c.230A>G	c.(229-231)gAa>gGa	p.E77G	CNTD2_ENST00000433940.1_Missense_Mutation_p.E77G	NM_024877.3	NP_079153.2	B4DX65	B4DX65_HUMAN	cyclin N-terminal domain containing 2	77					regulation of cyclin-dependent protein kinase activity		protein kinase binding			lung(1)|prostate(1)	2						GTACTCGCGTTCTCCCTGCAG	0.746000													8	30					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910800	230910800	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:230910800C>T	ENST00000295190.4	-	4	1500	c.1042G>A	c.(1042-1044)Gag>Aag	p.E348K		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	348						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TCGTTTTGCTCCGATAAGTTA	0.418000													22	53					0	0	1	0	0
ZNF80	7634	broad.mit.edu	37	3	113955475	113955475	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:113955475G>A	ENST00000482457.2	-	1	950	c.447C>T	c.(445-447)atC>atT	p.I149I		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	149						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CACGATGCTGGATGAAGACAG	0.493000													51	81					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136260755	136260755	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:136260755C>T	ENST00000371957.3	+	9	838	c.731C>T	c.(730-732)tCc>tTc	p.S244F	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	244	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTGCGGAAGTCCCTCCGCCAG	0.557000													28	58					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021406	5021406	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:5021406C>T	ENST00000382545.3	+	2	1969	c.862C>T	c.(862-864)Ctg>Ttg	p.L288L	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	288					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGCCACCTCCCTGGCCATCCT	0.547000													50	92					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449466	35449466	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:35449466G>A	ENST00000404801.1	-	4	1679	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F	ZNF792_ENST00000605484.1_Silent_p.F364F	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CAATGTGGCTGAAGAATTTCC	0.483000													35	70					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106882313	106882313	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:106882313C>T	ENST00000286398.7	+	16	2290	c.2002C>T	c.(2002-2004)Cga>Tga	p.R668*	SMC2_ENST00000374793.3_Nonsense_Mutation_p.R668*|SMC2_ENST00000374787.3_Nonsense_Mutation_p.R668*|SMC2_ENST00000303219.8_Nonsense_Mutation_p.R668*	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	668	Flexible hinge.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						ATCAGGTGCTCGATCCCAGGC	0.393000													78	141					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73012685	73012685	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:73012685C>T	ENST00000261180.4	+	13	2297	c.2201C>T	c.(2200-2202)cCt>cTt	p.P734L	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	734					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GGCTATTTGCCTCAGAATATT	0.373000													37	83					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28188547	28188547	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:28188547A>G	ENST00000304658.5	-	3	701	c.201T>C	c.(199-201)gtT>gtC	p.V67V	XPO6_ENST00000565698.1_Silent_p.V53V	NM_015171.2	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	67	Importin N-terminal.				protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						TTACCTCAAAAACTGTTAAAC	0.373000													30	23					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3157847	3157847	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:3157847C>T	ENST00000262958.3	+	6	1124	c.866C>T	c.(865-867)tCc>tTc	p.S289F		NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	289					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		ATCCCCACCTCCCACCTGGCT	0.473000													77	110					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10442709	10442709	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:10442709C>T	ENST00000397077.1	-	7	1284	c.709G>A	c.(709-711)Gat>Aat	p.D237N	ATP2B2_ENST00000352432.4_Missense_Mutation_p.D237N|ATP2B2_ENST00000360273.2_Missense_Mutation_p.D237N|ATP2B2_ENST00000343816.4_Missense_Mutation_p.D237N|ATP2B2_ENST00000383800.4_Missense_Mutation_p.D237N			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	237					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GAGCTTTCATCAATCTTGAGG	0.587000													29	47					0	0	1	0	0
RHNO1	83695	broad.mit.edu	37	12	2994575	2994575	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:2994575C>T	ENST00000489288.2	+	2	195	c.43C>T	c.(43-45)Ccg>Tcg	p.P15S	RHNO1_ENST00000464682.2_Intron|RHNO1_ENST00000461997.2_Missense_Mutation_p.P15S	NM_001252499.2|NM_001257097.1|NM_001257098.1	NP_001239428.1|NP_001244026.1|NP_001244027.1			RAD9-HUS1-RAD1 interacting nuclear orphan 1																		CCAGAAAGCCCCGCTGCTGTT	0.557000													42	73					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163535	32163535	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:32163535C>T	ENST00000564145.1	-	0	65																											GGTGCCTTCTCCAAACTCATC	0.572000													24	86					0	0	1	0	0
NSA2	10412	broad.mit.edu	37	5	74066523	74066523	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:74066523G>A	ENST00000296802.5	+	4	779	c.410G>A	c.(409-411)cGa>cAa	p.R137Q	NSA2_ENST00000513356.1_3'UTR	NM_014886.3	NP_055701.1	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog (S. cerevisiae)	137	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex				breast(1)|endometrium(2)|kidney(1)|lung(1)|ovary(1)|skin(1)	7						AAAGTTATTCGAACAGGAAAG	0.373000													50	66					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41176598	41176598	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:41176598T>C	ENST00000263413.3	-	8	1411	c.1147A>G	c.(1147-1149)Agt>Ggt	p.S383G	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Missense_Mutation_p.S383G	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	383	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AGTTCCTCACTGCTAAACTGA	0.403000													27	42					0	0	1	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49963067	49963067	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:49963067C>T	ENST00000293350.4	+	4	624	c.461C>T	c.(460-462)tCc>tTc	p.S154F	ALDH16A1_ENST00000540132.1_Intron|ALDH16A1_ENST00000455361.2_Missense_Mutation_p.S154F|ALDH16A1_ENST00000433981.2_5'UTR	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	154							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		ATCCAGGCATCCACCCAGGAG	0.637000													27	52					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74466653	74466653	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:74466653G>A	ENST00000394019.2	-	21	2525	c.2128C>T	c.(2128-2130)Ctt>Ttt	p.L710F	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.L710F|SLC4A5_ENST00000358683.4_Missense_Mutation_p.L646F|SLC4A5_ENST00000359484.4_Missense_Mutation_p.L646F|SLC4A5_ENST00000377634.4_Missense_Mutation_p.L710F|SLC4A5_ENST00000346834.4_Missense_Mutation_p.L710F|SLC4A5_ENST00000377632.1_Missense_Mutation_p.L710F|SLC4A5_ENST00000357822.5_Missense_Mutation_p.L710F|SLC4A5_ENST00000483195.1_5'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	710						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GTGAGGTTAAGGAGGTTGTAC	0.557000													44	82					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13940885	13940885	+	Missense_Mutation	SNP	G	G	A	rs147446446	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:13940885G>A	ENST00000294489.6	+	5	1030	c.689G>A	c.(688-690)cGa>cAa	p.R230Q	PDPN_ENST00000376061.4_Missense_Mutation_p.R112Q|PDPN_ENST00000475043.1_Missense_Mutation_p.R112Q|PDPN_ENST00000509009.1_Missense_Mutation_p.R149Q|PDPN_ENST00000487038.1_Missense_Mutation_p.R112Q|PDPN_ENST00000513143.1_Missense_Mutation_p.R112Q|PDPN_ENST00000376057.4_Missense_Mutation_p.R230Q			Q86YL7	PDPN_HUMAN	podoplanin	154					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GTGGTTATGCGAAAAATGTCG	0.418000													32	64					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814163	137814163	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:137814163C>T	ENST00000409968.1	+	3	491	c.313C>T	c.(313-315)Cag>Tag	p.Q105*	THSD7B_ENST00000272643.3_Nonsense_Mutation_p.Q105*|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.Q74*					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGACCTCTTTCAGTGGGAGGT	0.537000													26	33					0	0	1	0	0
IL23R	149233	broad.mit.edu	37	1	67705956	67705956	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:67705956C>T	ENST00000347310.5	+	9	1311	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	IL23R_ENST00000395227.1_Silent_p.F125F|IL23R_ENST00000473881.1_Intron|IL23R_ENST00000371002.1_Intron	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	380					inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						ACAGATCATTCCGAACTGGGT	0.328000													24	41					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141986780	141986780	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:141986780C>T	ENST00000389484.3	-	6	1793	c.822G>A	c.(820-822)tgG>tgA	p.W274*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	274					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTGATTGTCCATTCATCTG	0.328000										TSP Lung(27;0.18)			29	71					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115534607	115534607	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:115534607G>A	ENST00000354462.3	+	3	192	c.34G>A	c.(34-36)Gag>Aag	p.E12K	PLEKHS1_ENST00000369309.1_Missense_Mutation_p.E82K|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.E262K|PLEKHS1_ENST00000361048.1_Missense_Mutation_p.E268K|PLEKHS1_ENST00000369312.4_Missense_Mutation_p.E180K					pleckstrin homology domain containing, family S member 1																		GACATCCCATGAGTCTGTGGA	0.453000													62	90					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95560406	95560406	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:95560406G>A	ENST00000526495.1	-	26	5474	c.5183C>T	c.(5182-5184)tCc>tTc	p.S1728F	DICER1_ENST00000541352.1_Missense_Mutation_p.S1728F|DICER1_ENST00000393063.1_Missense_Mutation_p.S1728F|DICER1_ENST00000556045.1_Missense_Mutation_p.S626F|DICER1_ENST00000527414.1_Missense_Mutation_p.S1728F|DICER1_ENST00000343455.3_Missense_Mutation_p.S1728F			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1728	RNase III 2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GACCCCCGGGGAGTGCTGCCG	0.532000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				38	74					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109849468	109849468	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:109849468C>T	ENST00000357155.1	-	1	195		c.e1+1		MYBPHL_ENST00000477962.1_Splice_Site	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like											central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CCATGGGTCACCTTCTATAGG	0.642000													13	31					0	0	1	0	0
PARP9	83666	broad.mit.edu	37	3	122271276	122271276	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:122271276G>A	ENST00000462315.1	-	5	1389	c.1096C>T	c.(1096-1098)Cct>Tct	p.P366S	PARP9_ENST00000477522.2_Missense_Mutation_p.P366S|PARP9_ENST00000360356.2_Missense_Mutation_p.P401S|PARP9_ENST00000492382.1_Intron|PARP9_ENST00000471785.1_Missense_Mutation_p.P366S	NM_001146106.1	NP_001139578.1	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	401	Macro 2.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		TGAGGTTTAGGAAATTCTGAA	0.318000													27	48					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35732408	35732408	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:35732408C>T	ENST00000187397.4	+	9	1053	c.597C>T	c.(595-597)gtC>gtT	p.V199V	ARPP21_ENST00000337271.5_Silent_p.V199V|ARPP21_ENST00000444190.1_Silent_p.V199V|ARPP21_ENST00000417925.1_Silent_p.V199V|ARPP21_ENST00000458225.1_Silent_p.V199V	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	199	R3H.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GGATGCTTGTCCATCGAGTGG	0.383000													54	70					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532393	40532393	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:40532393G>A	ENST00000297737.6	-	5	553	c.407C>T	c.(406-408)tCt>tTt	p.S136F	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	136						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TTGATAGGGAGATGCGACCAC	0.517000													120	170					0	0	1	0	0
PPP1R9B	84687	broad.mit.edu	37	17	48222508	48222508	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:48222508A>G	ENST00000316878.6	-	4	1470	c.1468T>C	c.(1468-1470)Ttg>Ctg	p.L490L	AC002401.1_ENST00000451776.1_RNA|PPP1R9B_ENST00000501501.2_5'UTR	NM_032595.3	NP_115984.3	Q96SB3	NEB2_HUMAN	protein phosphatase 1, regulatory subunit 9B	490	Interacts with RGS2 (By similarity).|Interacts with protein phosphatase 1 (By similarity).				cell cycle arrest|cell differentiation|cell migration|filopodium assembly|negative regulation of cell growth|nervous system development|regulation of cell growth by extracellular stimulus|regulation of cell proliferation|regulation of exit from mitosis|RNA splicing	adherens junction|cytoskeleton|dendritic spine|filopodium|lamellipodium|nucleoplasm|protein phosphatase type 1 complex|ruffle membrane|synapse	actin binding|protein phosphatase 1 binding|protein phosphatase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8						AACAGCTCCAACCTCTCCACA	0.597000													29	45					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37454062	37454062	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:37454062A>G	ENST00000374660.1	+	18	1974	c.1875A>G	c.(1873-1875)gaA>gaG	p.E625E	ANKRD30A_ENST00000361713.1_Silent_p.E625E|ANKRD30A_ENST00000602533.1_Silent_p.E625E			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	681						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AGGACTATGAAGAAAATTCTT	0.289000													33	60					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68526075	68526075	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:68526075C>T	ENST00000433211.1	-	9	1402	c.1228G>A	c.(1228-1230)Gaa>Aaa	p.E410K	CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000373744.4_Missense_Mutation_p.E410K	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	410					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TCTTTTATTTCCTTTTCCCGG	0.443000													68	135					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77626767	77626767	+	Splice_Site	SNP	T	T	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:77626767T>A	ENST00000461745.1	+	15	3228		c.e15+2		ROBO2_ENST00000487694.3_Splice_Site|ROBO2_ENST00000332191.8_Splice_Site	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)						apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GAATACAAGGTAGGACCCGGG	0.438000													24	41					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73560510	73560510	+	Missense_Mutation	SNP	G	G	A	rs34553577		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:73560510G>A	ENST00000392550.3	+	10	1075	c.958G>A	c.(958-960)Gat>Aat	p.D320N	LLGL2_ENST00000577200.1_Missense_Mutation_p.D320N|LLGL2_ENST00000375227.4_Missense_Mutation_p.D320N|LLGL2_ENST00000578363.1_Missense_Mutation_p.D320N|LLGL2_ENST00000167462.5_Missense_Mutation_p.D320N	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	320					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding	p.D320N(2)		NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGTGATCCACGATGGCCAGCA	0.637000													32	52					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76744409	76744409	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:76744409C>T	ENST00000369963.3	-	2	352	c.163G>A	c.(163-165)Gag>Aag	p.E55K	IMPG1_ENST00000369950.3_Missense_Mutation_p.E133K			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	133					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CAGAAGGTCTCCTGCTGGCAG	0.498000													48	26					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237777681	237777681	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:237777681C>T	ENST00000366574.2	+	37	5570	c.5253C>T	c.(5251-5253)atC>atT	p.I1751I	RYR2_ENST00000360064.6_Silent_p.I1749I|RYR2_ENST00000542537.1_Silent_p.I1735I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1751	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCCAGGGATCGGCCTCAGCA	0.517000													25	68					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7911259	7911259	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:7911259G>A	ENST00000254854.4	+	7	1727	c.1577G>A	c.(1576-1578)gGg>gAg	p.G526E		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	526	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				GTGGCCCAGGGGAGTCGATCA	0.542000													9	37					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951996	119951996	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:119951996G>A	ENST00000307142.4	+	4	2262	c.2066G>A	c.(2065-2067)aGg>aAg	p.R689K	SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Missense_Mutation_p.R689K|SYNPO2_ENST00000429713.2_Missense_Mutation_p.R689K	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	689						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GAGGCCAAAAGGAGAAGCACG	0.468000													18	59					0	0	1	0	0
DGCR14	8220	broad.mit.edu	37	22	19127225	19127225	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:19127225G>A	ENST00000252137.6	-	5	631	c.588C>T	c.(586-588)ctC>ctT	p.L196L		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	196					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					ACGGGAGTTCGAGATTATCTT	0.562000													43	88					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50467675	50467675	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:50467675G>A	ENST00000331340.3	+	8	1065	c.910G>A	c.(910-912)Gaa>Aaa	p.E304K	IKZF1_ENST00000343574.5_Missense_Mutation_p.E217K|IKZF1_ENST00000438033.1_Missense_Mutation_p.E217K|IKZF1_ENST00000357364.4_Missense_Mutation_p.E217K|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000346667.4_Missense_Mutation_p.E74K|IKZF1_ENST00000439701.1_Missense_Mutation_p.E262K|IKZF1_ENST00000359197.5_Missense_Mutation_p.E262K|IKZF1_ENST00000349824.4_Missense_Mutation_p.E161K	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	304					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAAGGAGAACGAAATGATGAA	0.652000			"""D,T"""	BCL6	"""ALL, DLBCL"""								10	16					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155505958	155505958	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:155505958G>A	ENST00000302053.3	-	6	1997	c.1919C>T	c.(1918-1920)cCt>cTt	p.P640L		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	640	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GGTACCTGAAGGATGTGTTTG	0.388000													28	56					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33497236	33497236	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:33497236G>A	ENST00000268876.5	+	12	1748	c.1651G>A	c.(1651-1653)Gac>Aac	p.D551N	UNC45B_ENST00000591048.1_Intron|UNC45B_ENST00000433649.1_Missense_Mutation_p.D551N|UNC45B_ENST00000394570.2_Missense_Mutation_p.D551N|UNC45B_ENST00000378449.1_Intron	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	551					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				CTTTGTCCAGGACGTCCCTGC	0.622000													26	38					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67047099	67047099	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:67047099C>T	ENST00000308595.5	+	5	659	c.369C>T	c.(367-369)ccC>ccT	p.P123P	ADRBK1_ENST00000526285.1_Silent_p.P123P	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	123	N-terminal.|RGS.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	TTCCCCAGCCCTTCTCGAAGA	0.627000													23	68					0	0	1	0	0
LZTFL1	54585	broad.mit.edu	37	3	45874551	45874551	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:45874551G>A	ENST00000296135.6	-	5	621	c.447C>T	c.(445-447)ctC>ctT	p.L149L	LZTFL1_ENST00000539217.1_Silent_p.L145L|LZTFL1_ENST00000536047.1_Silent_p.L132L|LZTFL1_ENST00000490463.1_5'UTR	NM_001276378.1|NM_020347.2	NP_001263307.1|NP_065080.1	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	149										endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	8				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		CCTTGTTTAGGAGTTCTGCTG	0.393000													36	55					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70732278	70732278	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:70732278G>A	ENST00000229195.3	+	10	1535	c.956G>A	c.(955-957)gGa>gAa	p.G319E	CNOT2_ENST00000551483.1_5'UTR|CNOT2_ENST00000418359.3_Missense_Mutation_p.G319E	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	319					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			AAATTCCCTGGAGATAAAAGT	0.328000													47	87					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62463999	62463999	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:62463999C>T	ENST00000383710.4	-	23	3615	c.3266G>A	c.(3265-3267)gGa>gAa	p.G1089E	CADPS_ENST00000283269.9_Missense_Mutation_p.G1050E|CADPS_ENST00000357948.3_Missense_Mutation_p.G1010E	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1089	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CAGGTGCTTTCCAAACTCTTC	0.502000													42	59					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42509959	42509959	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:42509959C>T	ENST00000262895.3	-	16	2178	c.2179G>A	c.(2179-2181)Gaa>Aaa	p.E727K	GRIK5_ENST00000593562.1_Missense_Mutation_p.E727K|GRIK5_ENST00000301218.4_Missense_Mutation_p.E727K	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	727						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CGGTGGTATTCGTTCATGGTG	0.627000													17	26					0	0	1	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58189626	58189626	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:58189626C>T	ENST00000318203.5	+	5	1352	c.655C>T	c.(655-657)Cta>Tta	p.L219L		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	219					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AATAGTTTCCCTAATCATCAT	0.408000													30	33					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428968	48428968	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:48428968C>T	ENST00000224605.2	-	2	1183	c.918G>A	c.(916-918)ctG>ctA	p.L306L		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	306					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						GCCTCTCATCCAGCCCCGGCA	0.741000													8	19					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97915658	97915658	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:97915658C>T	ENST00000370192.3	-	14	1962	c.1862G>A	c.(1861-1863)tGg>tAg	p.W621*		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	621					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ACTTTGACACCAATATGCAGC	0.438000													53	82					0	0	1	0	0
WDR76	79968	broad.mit.edu	37	15	44150935	44150935	+	Silent	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:44150935T>C	ENST00000263795.6	+	11	1546	c.1476T>C	c.(1474-1476)acT>acC	p.T492T	WDR76_ENST00000381246.2_Silent_p.T428T|WDR76_ENST00000478130.1_3'UTR	NM_001167941.1|NM_024908.3	NP_001161413.1|NP_079184.2	Q9H967	WDR76_HUMAN	WD repeat domain 76	492										breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)	20		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		TTTCTTTGACTGAACATACAA	0.408000													52	99					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41352931	41352931	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:41352931G>A	ENST00000551295.2	+	15	1816	c.1699G>A	c.(1699-1701)Gaa>Aaa	p.E567K	CNTN1_ENST00000348761.2_Missense_Mutation_p.E556K|CNTN1_ENST00000347616.1_Missense_Mutation_p.E567K|CNTN1_ENST00000360099.3_Missense_Mutation_p.E567K|CNTN1_ENST00000547849.1_Missense_Mutation_p.E567K|CNTN1_ENST00000547702.1_Missense_Mutation_p.E567K	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	567	Ig-like C2-type 6.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTCCAATGGGGAATTACTAAT	0.403000													28	42					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10403393	10403393	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:10403393G>A	ENST00000221980.4	+	5	1130	c.1067G>A	c.(1066-1068)gGa>gAa	p.G356E		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	356	Ig-like C2-type 4.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			ACACTGGAGGGAGTTCCAGCC	0.657000													18	28					0	0	1	0	0
SHOX2	6474	broad.mit.edu	37	3	157820623	157820623	+	Silent	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:157820623T>C	ENST00000490689.2	-	2	1545	c.12A>G	c.(10-12)gaA>gaG	p.E4E	SHOX2_ENST00000483851.2_Silent_p.E133E|SHOX2_ENST00000441443.2_Silent_p.E4E|SHOX2_ENST00000425436.3_Silent_p.E133E|SHOX2_ENST00000554685.1_5'UTR|SHOX2_ENST00000389589.4_Silent_p.E157E			O60902	SHOX2_HUMAN	short stature homeobox 2	133					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(10)|skin(3)|upper_aerodigestive_tract(1)	20			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TGGTCTGGCCTTCGTCCTCCA	0.572000													59	98					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7911260	7911260	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:7911260G>A	ENST00000254854.4	+	7	1728	c.1578G>A	c.(1576-1578)ggG>ggA	p.G526G		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	526	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TGGCCCAGGGGAGTCGATCAA	0.537000													9	38					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435975	5435975	+	Silent	SNP	G	G	A	rs142943186	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:5435975G>A	ENST00000380419.3	-	4	883	c.846C>T	c.(844-846)atC>atT	p.I282I	TUBAL3_ENST00000479328.1_Silent_p.I242I	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	282					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						CAGCAGAGACGATGGGGGCGA	0.517000													50	109					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46396983	46396983	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:46396983C>T	ENST00000454345.1	+	21	2401	c.2274_splice	c.e21-1	p.A759_splice	DGKZ_ENST00000528615.1_Splice_Site_p.A349_splice|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000527911.1_Splice_Site_p.A571_splice|DGKZ_ENST00000343674.6_Splice_Site_p.A587_splice|DGKZ_ENST00000421244.2_Splice_Site_p.A571_splice|DGKZ_ENST00000318201.8_Splice_Site_p.A548_splice|DGKZ_ENST00000456247.2_Splice_Site_p.A570_splice|DGKZ_ENST00000532868.2_Splice_Site_p.A575_splice|DGKZ_ENST00000395574.3_Splice_Site_p.A537_splice	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	759					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TGCCCACAGGCCGCGCTGCAG	0.667000													9	7					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71354312	71354312	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:71354312G>A	ENST00000392650.3	-	40	5499	c.5499C>T	c.(5497-5499)atC>atT	p.I1833I	SDK2_ENST00000388726.3_Silent_p.I1814I|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1833	Fibronectin type-III 13.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TGTACCGCACGATGATGGGCA	0.657000													90	114					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90106260	90106260	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:90106260G>A	ENST00000405460.2	+	74	15279	c.15183G>A	c.(15181-15183)ggG>ggA	p.G5061G	GPR98_ENST00000425867.2_Silent_p.G722G	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5061	Calx-beta 33.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCAGAATGGGGAACTGTTTT	0.353000													9	27					0	0	1	0	0
ASB18	401036	broad.mit.edu	37	2	237172889	237172889	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:237172889C>T	ENST00000409749.3	-	1	99	c.100G>A	c.(100-102)Gat>Aat	p.D34N	AC079135.1_ENST00000415226.1_RNA	NM_212556.2	NP_997721.2	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box containing 18	34					intracellular signal transduction					large_intestine(1)|lung(3)|ovary(1)|prostate(1)	6		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		CAGATTAAATCCCTCACTCTC	0.507000													27	50					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143091909	143091909	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:143091909C>T	ENST00000275815.3	-	14	2430	c.2344G>A	c.(2344-2346)Gaa>Aaa	p.E782K		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	782	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				ACCTGGGTTTCGTATGTGCCA	0.502000													20	27					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039268	11039268	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr21:11039268C>T	ENST00000470054.1	-	0	935									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGCAGTTGCTCTTGCTGCACA	0.393000													34	449					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130410928	130410928	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:130410928C>T	ENST00000370904.1	-	20	3476	c.2566G>A	c.(2566-2568)Gag>Aag	p.E856K	IGSF1_ENST00000361420.3_Missense_Mutation_p.E865K|IGSF1_ENST00000370903.3_Missense_Mutation_p.E870K|IGSF1_ENST00000467244.1_5'UTR|IGSF1_ENST00000370910.1_Missense_Mutation_p.E856K			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	865	Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						ACCACGAGCTCCACAGGGTCG	0.532000													112	39					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10517195	10517195	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:10517195G>A	ENST00000444303.2	+	8	1340	c.868G>A	c.(868-870)Gag>Aag	p.E290K	AMPD3_ENST00000396554.3_Missense_Mutation_p.E458K	NM_001172431.1	NP_001165902.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	449					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CAGTCCTGAGGAGTGGCCCAA	0.592000													25	25					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50835683	50835683	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:50835683C>T	ENST00000395562.2	+	8	1186	c.717C>T	c.(715-717)ttC>ttT	p.F239F	CHAT_ENST00000339797.1_Silent_p.F203F|CHAT_ENST00000455728.2_Silent_p.F203F|CHAT_ENST00000351556.3_Silent_p.F203F|CHAT_ENST00000337653.2_Silent_p.F321F|CHAT_ENST00000395559.2_Silent_p.F203F	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	321					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TCATTAATTTCCGCCGTCTCA	0.507000													85	126					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149515803	149515803	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:149515803C>T	ENST00000378016.2	+	0	11704							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCCGCTCGCCCTGCATGGCG	0.687000													10	11					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004218	75004218	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:75004218C>T	ENST00000373359.2	-	1	861	c.669G>A	c.(667-669)agG>agA	p.R223R		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	223	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TGAGGAGGTTCCTTGTGTTCC	0.493000													51	15					0	0	1	0	0
CDCA3	83461	broad.mit.edu	37	12	6958951	6958951	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:6958951G>A	ENST00000422785.3	-	4	426	c.322C>T	c.(322-324)Cca>Tca	p.P108S	CDCA3_ENST00000540683.1_Missense_Mutation_p.P108S|CDCA3_ENST00000538862.2_Missense_Mutation_p.P108S|CDCA3_ENST00000229265.6_Intron|CDCA3_ENST00000535406.1_Missense_Mutation_p.P108S			Q99618	CDCA3_HUMAN	cell division cycle associated 3	108	F-box-like.				cell division|mitosis	cytosol				breast(1)|endometrium(1)|large_intestine(4)|lung(1)|stomach(1)	8						ACAGGCTCTGGGGGAAGATTT	0.483000													51	89					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15794027	15794027	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:15794027C>T	ENST00000359621.4	+	7	811	c.786C>T	c.(784-786)atC>atT	p.I262I	CELA2B_ENST00000494280.1_3'UTR	NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	262	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						TCGACTGGATCAATTCGGTAA	0.612000													38	62					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047457	9047457	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:9047457G>A	ENST00000397910.4	-	5	34377	c.34174C>T	c.(34174-34176)Cca>Tca	p.P11392S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11394	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTATTGTTGGAAAATCTGAA	0.458000													84	110					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29498006	29498006	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:29498006C>T	ENST00000389048.3	-	11	2906	c.2000G>A	c.(1999-2001)gGg>gAg	p.G667E	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	667					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGAATTTTCCCCGGGTTTCAG	0.458000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				20	55					0	0	1	0	0
ZNF268	10795	broad.mit.edu	37	12	133779970	133779970	+	Silent	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:133779970T>C	ENST00000536435.2	+	6	2028	c.1698T>C	c.(1696-1698)agT>agC	p.S566S	ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000537565.1_Silent_p.S405S|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000228289.5_Silent_p.S566S|ZNF268_ENST00000542986.2_3'UTR	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	566						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AAGCCTTCAGTCGGAAATACC	0.433000													10	8					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657174	143657174	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:143657174G>A	ENST00000392899.1	+	1	148	c.111G>A	c.(109-111)gtG>gtA	p.V37V		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					TGTATGTGGTGACCGTGCTGG	0.512000													133	189					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47244153	47244153	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:47244153C>T	ENST00000371941.3	-	39	4892	c.4869_splice	c.e39-1	p.G1624_splice	PREX1_ENST00000396220.1_3'UTR	NM_020820.3	NP_065871.2	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	1624					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			ACCCTTGGGCCCTGGAAGAAG	0.657000													35	45					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64977815	64977815	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:64977815C>T	ENST00000527323.1	+	19	2191	c.1951C>T	c.(1951-1953)Ctc>Ttc	p.L651F	CAPN1_ENST00000279247.6_Missense_Mutation_p.L651F|CAPN1_ENST00000533129.1_Missense_Mutation_p.L651F|CAPN1_ENST00000524773.1_Missense_Mutation_p.L651F|CAPN1_ENST00000533820.1_Missense_Mutation_p.L651F			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	651	Domain IV.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		AGGCTTCAAGCTCAACAAGAA	0.617000													11	13					0	0	1	0	0
PRND	23627	broad.mit.edu	37	20	4705302	4705302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:4705302G>A	ENST00000305817.2	+	2	176	c.105G>A	c.(103-105)tgG>tgA	p.W35*		NM_012409.2	NP_036541.2	Q9UKY0	PRND_HUMAN	prion protein 2 (dublet)	35	Flexible tail.				protein homooligomerization	anchored to membrane|plasma membrane				breast(3)|endometrium(2)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	13						GAATCAAGTGGAACCGGAAGG	0.622000													33	64					0	0	1	0	0
EIF1AY	9086	broad.mit.edu	37	Y	22737761	22737761	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrY:22737761C>T	ENST00000361365.2	+	1	151	c.4C>T	c.(4-6)Ccc>Tcc	p.P2S	EIF1AY_ENST00000382772.3_Missense_Mutation_p.P2S	NM_004681.3	NP_004672.2	O14602	IF1AY_HUMAN	eukaryotic translation initiation factor 1A, Y-linked	2						cytoplasm	protein binding|translation initiation factor activity										CACCGCCATGCCCAAGAATAA	0.557000													10	1					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84533293	84533293	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:84533293C>T	ENST00000527857.1	+	0	3315					NR_026851.1																						ACTTTTCTGCCCCCCACATAC	0.502000													6	13					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413011	124413011	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:124413011G>A	ENST00000306842.2	-	1	564	c.540C>T	c.(538-540)atC>atT	p.I180I		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GGAGAGGAAGGATGTCACACA	0.498000													31	40					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	472937	472937	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:472937G>A	ENST00000217244.3	-	9	957	c.582C>T	c.(580-582)tcC>tcT	p.S194S	CSNK2A1_ENST00000400217.1_Silent_p.S58S|CSNK2A1_ENST00000460062.1_5'UTR|CSNK2A1_ENST00000349736.5_Silent_p.S194S|CSNK2A1_ENST00000400227.3_Silent_p.S194S	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	194	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			TGAAGTATCGGGAAGCAACTC	0.408000													13	35					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22890729	22890729	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:22890729G>A	ENST00000543184.1	-	5	2152	c.1290C>T	c.(1288-1290)ctC>ctT	p.L430L	PRAME_ENST00000398743.2_Silent_p.L430L|PRAME_ENST00000539862.1_Silent_p.L414L|PRAME_ENST00000402697.1_Silent_p.L430L|PRAME_ENST00000424204.2_Silent_p.L414L|PRAME_ENST00000398741.1_Silent_p.L430L|PRAME_ENST00000405655.3_Silent_p.L430L	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	430	Mediates interaction with RARA.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		TCAGCCCGATGAGGTGCTGCA	0.562000													58	90					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92926918	92926918	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:92926918C>T	ENST00000373079.3	-	1	1649	c.1386G>A	c.(1384-1386)ctG>ctA	p.L462L	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	462					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						AGTCCTCATCCAGGATAGCAT	0.398000													28	6					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140249988	140249988	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:140249988C>T	ENST00000398640.2	+	1	1300	c.1300C>T	c.(1300-1302)Ctg>Ttg	p.L434L	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGCCTTCTCTGTGGGCCAC	0.612000													130	182					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203708702	203708702	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:203708702C>T	ENST00000357681.5	+	21	4461	c.3338C>T	c.(3337-3339)tCc>tTc	p.S1113F	ATP2B4_ENST00000341360.2_3'UTR|ATP2B4_ENST00000367219.3_3'UTR|ATP2B4_ENST00000367218.3_3'UTR|ATP2B4_ENST00000391954.2_3'UTR	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	1149	Calmodulin-binding subdomain B (By similarity).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TTCCATAGTTCCCTCCACGAA	0.488000													89	81					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33875198	33875198	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:33875198G>A	ENST00000374408.3	-	4	1480	c.1384C>T	c.(1384-1386)Ctg>Ttg	p.L462L		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	462										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			AACCGGGACAGAGCTGGGGCA	0.632000													25	47					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140082507	140082507	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:140082507G>A	ENST00000323927.2	-	2	170	c.166C>T	c.(166-168)Cgg>Tgg	p.R56W		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	56					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		ACCGCCGCCCGGAGCTCCTCT	0.642000													12	26					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201061109	201061109	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:201061109C>T	ENST00000362061.3	-	4	758	c.532G>A	c.(532-534)Ggg>Agg	p.G178R	CACNA1S_ENST00000367338.3_Missense_Mutation_p.G178R	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	178					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTAGGCACCCCCGACACCAGC	0.612000													43	38					0	0	1	0	0
XPO5	57510	broad.mit.edu	37	6	43514469	43514469	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:43514469G>A	ENST00000265351.7	-	20	2391	c.2181C>T	c.(2179-2181)agC>agT	p.S727S		NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	727					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			CACCCAGAATGCTGTATACAC	0.373000													11	6					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36221442	36221442	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:36221442C>T	ENST00000222270.7	+	25	5201	c.5201C>T	c.(5200-5202)tCc>tTc	p.S1734F	WBP7_ENST00000420124.1_Missense_Mutation_p.S1734F|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					ACCACAGGTTCCATCCGCATT	0.607000													175	306					0	0	1	0	0
AQP11	282679	broad.mit.edu	37	11	77301058	77301058	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:77301058C>T	ENST00000313578.3	+	1	379	c.21C>T	c.(19-21)ctC>ctT	p.L7L	AQP11_ENST00000528638.1_Intron	NM_173039.2	NP_766627.1	Q8NBQ7	AQP11_HUMAN	aquaporin 11	7						cell surface|integral to membrane	transporter activity			kidney(2)|large_intestine(1)|lung(5)	8	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			TGCTGGGGCTCCGGTCCGAGC	0.711000													11	21					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275729	130275729	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:130275729G>A	ENST00000257359.6	-	9	3100	c.2394C>T	c.(2392-2394)ttC>ttT	p.F798F		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	798	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CTTTTGGGGGGAAGACCTCGC	0.572000													113	217					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28723643	28723643	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:28723643G>A	ENST00000257197.3	-	8	1312	c.1051C>T	c.(1051-1053)Cca>Tca	p.P351S	DSC1_ENST00000257198.5_Missense_Mutation_p.P351S|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	351	Cadherin 2.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AAAGATGGTGGATTGTCATTT	0.348000													23	41					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50678350	50678350	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:50678350C>T	ENST00000355832.5	-	18	3734	c.3656G>A	c.(3655-3657)gGa>gAa	p.G1219E	ERCC6_ENST00000542458.1_Missense_Mutation_p.G589E|RP11-123B3.2_ENST00000423283.1_RNA	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	1219					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AATTCGAGTTCCTTCAAACTT	0.443000								Direct reversal of damage;Nucleotide excision repair (NER)					152	289					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19856851	19856851	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:19856851C>T	ENST00000548109.1	+	0	72																											GCTCTCATGTCATCTACAGCA	0.333000													4	66					0	0	1	0	0
FAM160B2	64760	broad.mit.edu	37	8	21959748	21959748	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:21959748C>T	ENST00000289921.7	+	15	1960	c.1914C>T	c.(1912-1914)ccC>ccT	p.P638P		NM_022749.5	NP_073586.5	Q86V87	F16B2_HUMAN	family with sequence similarity 160, member B2	638										endometrium(2)|kidney(1)|lung(2)|prostate(3)|urinary_tract(1)	9						TCCCCCACCCCCATATTCATG	0.632000													29	54					0	0	1	0	0
CCNL1	57018	broad.mit.edu	37	3	156868171	156868171	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:156868171C>T	ENST00000295926.3	-	6	793		c.e6-1		CCNL1_ENST00000461804.1_Splice_Site|CCNL1_ENST00000479052.1_Splice_Site	NM_020307.2	NP_064703.1	Q9UK58	CCNL1_HUMAN	cyclin L1						regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			NS(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			CATGTAATTCCTGAAAAATAT	0.358000													11	26					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52200426	52200426	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:52200426C>T	ENST00000354534.5	+	27	5334	c.5156C>T	c.(5155-5157)cCt>cTt	p.P1719L	SCN8A_ENST00000545061.1_Missense_Mutation_p.P1678L	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1719					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AACCGCCCCCCTGACTGCAGC	0.507000													27	52					0	0	1	0	0
IGHG4	3503	broad.mit.edu	37	14	106091309	106091309	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:106091309G>A	ENST00000390543.2	-	0	584																											ACTCCTTGCCGTTCAGCCAGT	0.592000													5	560					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53993701	53993701	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:53993701G>A	ENST00000396403.4	+	4	343	c.215G>A	c.(214-216)gGg>gAg	p.G72E	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	72	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ATCCACACAGGGACATTGCAA	0.373000													50	97					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48598577	48598577	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:48598577C>T	ENST00000323776.5	+	8	1314	c.1152C>T	c.(1150-1152)ttC>ttT	p.F384F	MYCBPAP_ENST00000436259.2_Silent_p.F347F	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	347					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			AGCTGGATTTCAGCCAGCAGG	0.562000													6	14					0	0	1	0	0
PGLS	25796	broad.mit.edu	37	19	17628118	17628118	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:17628118C>T	ENST00000252603.2	+	3	462	c.418C>T	c.(418-420)Ccg>Tcg	p.P140S		NM_012088.2	NP_036220.1	O95336	6PGL_HUMAN	6-phosphogluconolactonase	140						cytosol	6-phosphogluconolactonase activity			endometrium(1)|lung(1)	2						GGACTCCATCCCGGTTTTCGA	0.617000													102	215					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165356	151165356	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:151165356C>T	ENST00000282466.3	-	4	2412	c.2413G>A	c.(2413-2415)Gaa>Aaa	p.E805K		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	805					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACCATAAATTCCTCATGTAGA	0.478000													51	75					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138378223	138378223	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:138378223G>A	ENST00000409968.1	+	20	3904	c.3726G>A	c.(3724-3726)gtG>gtA	p.V1242V	THSD7B_ENST00000272643.3_Silent_p.V1245V|THSD7B_ENST00000413152.2_Silent_p.V1214V|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGCTTGGTGGAATGCGTGG	0.463000													49	94					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768301	117768301	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:117768301T>C	ENST00000317775.6	-	2	1259	c.574A>G	c.(574-576)Acc>Gcc	p.T192A	NOS1_ENST00000344089.3_Missense_Mutation_p.T192A|NOS1_ENST00000338101.4_Missense_Mutation_p.T192A	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	192	Interaction with NOSIP (By similarity).|PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTGACTCTGGTTGCTTTCTTC	0.632000													85	124					0	0	1	0	0
FGFBP2	83888	broad.mit.edu	37	4	15964132	15964132	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:15964132C>T	ENST00000259989.6	-	1	727	c.621G>A	c.(619-621)tgG>tgA	p.W207*	FGFBP2_ENST00000509331.1_Intron	NM_031950.3	NP_114156.1	Q9BYJ0	FGFP2_HUMAN	fibroblast growth factor binding protein 2	207						extracellular space	growth factor binding			central_nervous_system(1)|lung(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	9						GGAAGGGTTTCCAACAATGTT	0.547000													42	59					0	0	1	0	0
TNIP3	79931	broad.mit.edu	37	4	122078270	122078270	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:122078270C>T	ENST00000454328.1	-	6	569	c.342G>A	c.(340-342)cgG>cgA	p.R114R	TNIP3_ENST00000057513.3_Silent_p.R114R|TNIP3_ENST00000507879.1_Silent_p.R184R|TNIP3_ENST00000509841.1_Silent_p.R191R			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	114										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						GCAGCCGGTCCCGGGTCAGGT	0.637000													153	268					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24121399	24121399	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:24121399G>A	ENST00000215743.3	+	2	186	c.134G>A	c.(133-135)aGg>aAg	p.R45K	MMP11_ENST00000477567.1_3'UTR	NM_005940.3	NP_005931.2	P24347	MMP11_HUMAN	matrix metallopeptidase 11 (stromelysin 3)	45					collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	27		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				CATGCCGAGAGGAGGGGGCCA	0.682000													8	12					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480454	73480454	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:73480454G>A	ENST00000523207.1	+	2	1073	c.485G>A	c.(484-486)cGa>cAa	p.R162Q		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	162				ER -> DG (in Ref. 1; AAP46292).	regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding	p.R162Q(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			ATGCGAGAGCGAGAAGGAGAA	0.458000													53	146					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183217534	183217534	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:183217534C>T	ENST00000341319.3	-	4	1026	c.991G>A	c.(991-993)Gaa>Aaa	p.E331K		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	331										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			ACAAACCGTTCATCCTTCGTG	0.577000													85	50					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93065372	93065372	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:93065372G>A	ENST00000359558.2	-	14	1442	c.1143C>T	c.(1141-1143)atC>atT	p.I381I	CALCR_ENST00000421592.1_Silent_p.I363I|CALCR_ENST00000360249.4_Silent_p.I363I|CALCR_ENST00000394441.1_Silent_p.I347I|CALCR_ENST00000426151.1_Silent_p.I347I	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	363					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GGGGCACAAGGATCATGGTGG	0.493000													22	47					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109270446	109270446	+	Silent	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:109270446T>C	ENST00000370017.3	+	7	1405	c.1128T>C	c.(1126-1128)agT>agC	p.S376S	FNDC7_ENST00000271311.2_Silent_p.S377S	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	377	Fibronectin type-III 5.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GTTGTCCTAGTGACATTAACC	0.542000													86	126					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628194	3628194	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:3628194G>A	ENST00000325418.4	+	1	984	c.965G>A	c.(964-966)cGc>cAc	p.R322H	ITGAE_ENST00000571185.1_Intron|ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	322					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity	p.R322H(1)									CCCAAGGGCCGCATTGTGCCA	0.582000													4	86					0	0	1	0	0
SNRNP27	11017	broad.mit.edu	37	2	70122296	70122296	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:70122296G>A	ENST00000244227.3	+	2	530	c.105G>A	c.(103-105)gaG>gaA	p.E35E	SNRNP27_ENST00000409116.1_Silent_p.E35E	NM_006857.2	NP_006848.1	Q8WVK2	SNR27_HUMAN	small nuclear ribonucleoprotein 27kDa (U4/U6.U5)	35	Arg-rich.				mRNA processing|RNA splicing	nucleus	nucleic acid binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	11						GGTCTCGGGAGAGAGATCGGA	0.552000													60	99					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84564872	84564872	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:84564872G>A	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							AAAACACTGTGTTCAGTGATG	0.468000													3	3					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25121453	25121453	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:25121453G>C	ENST00000332271.5	-	17	2482	c.2066C>G	c.(2065-2067)aCa>aGa	p.T689R	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000533313.1_Missense_Mutation_p.T571R|PIWIL3_ENST00000527701.1_Missense_Mutation_p.T571R	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	689	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CTCTTCTCCTGTTTTCTGGAT	0.428000													42	77					0	0	1	0	0
COMT	1312	broad.mit.edu	37	22	19956206	19956206	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:19956206G>T	ENST00000361682.6	+	6	1145	c.763G>T	c.(763-765)Gac>Tac	p.D255Y	COMT_ENST00000449653.1_Missense_Mutation_p.D205Y|COMT_ENST00000407537.1_Missense_Mutation_p.D205Y|COMT_ENST00000403710.1_Missense_Mutation_p.D255Y|COMT_ENST00000406520.3_Missense_Mutation_p.D255Y	NM_000754.3	NP_000745.1	P21964	COMT_HUMAN	catechol-O-methyltransferase	255					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			kidney(1)|lung(1)|ovary(1)|prostate(1)|stomach(1)	5	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	GGAGGTGGTGGACGGCCTGGA	0.647000													25	41					3.73148e-12	3.76722e-12	1	1	0
ENDOD1	23052	broad.mit.edu	37	11	94862016	94862016	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:94862016C>T	ENST00000278505.4	+	2	894	c.776C>T	c.(775-777)cCa>cTa	p.P259L		NM_015036.2	NP_055851.1	O94919	ENDD1_HUMAN	endonuclease domain containing 1	259						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				AAACTGCTTCCATTTAACCCT	0.458000													34	43					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89923388	89923388	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:89923388C>T	ENST00000405460.2	+	7	1129	c.1033C>T	c.(1033-1035)Caa>Taa	p.Q345*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	345	Calx-beta 3.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTGAAATTTCAAATAGTTGA	0.388000													77	146					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1902632	1902632	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:1902632C>T	ENST00000503128.1	+	2	458	c.251C>T	c.(250-252)tCc>tTc	p.S84F	WHSC1_ENST00000514045.1_Missense_Mutation_p.S84F|WHSC1_ENST00000508803.1_Missense_Mutation_p.S84F|WHSC1_ENST00000436793.1_Missense_Mutation_p.S84F|WHSC1_ENST00000382895.3_Missense_Mutation_p.S84F|WHSC1_ENST00000382892.2_Missense_Mutation_p.S84F|WHSC1_ENST00000382891.5_Missense_Mutation_p.S84F|WHSC1_ENST00000420906.2_Missense_Mutation_p.S84F|WHSC1_ENST00000398261.1_Missense_Mutation_p.S84F			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	84					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GATCTTACTTCCCGGGTGTTT	0.552000			T	IGH@	MM								48	61					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120998805	120998805	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:120998805C>T	ENST00000392793.1	+	9	2390	c.2119C>T	c.(2119-2121)Ccc>Tcc	p.P707S	TECTA_ENST00000264037.2_Missense_Mutation_p.P707S			O75443	TECTA_HUMAN	tectorin alpha	707					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGGCTGCTTCCCCAAGCGGGA	0.657000													42	76					0	0	1	0	0
AGTR1	185	broad.mit.edu	37	3	148459740	148459740	+	Silent	SNP	G	G	A	rs1064535		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:148459740G>A	ENST00000542281.1	+	4	1364	c.918G>A	c.(916-918)ggG>ggA	p.G306G	AGTR1_ENST00000497524.1_Silent_p.G306G|AGTR1_ENST00000474935.1_Silent_p.G306G|AGTR1_ENST00000475347.1_Silent_p.G306G|AGTR1_ENST00000418473.2_Silent_p.G306G|AGTR1_ENST00000404754.2_Silent_p.G306G|AGTR1_ENST00000402260.1_Silent_p.G306G|AGTR1_ENST00000461609.1_Silent_p.G306G|AGTR1_ENST00000349243.3_Silent_p.G306G	NM_031850.3	NP_114038.4	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	306					calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	GCTTTCTGGGGAAAAAATTTA	0.368000													26	54					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44921440	44921440	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:44921440G>A	ENST00000261866.7	-	9	1898	c.1882C>T	c.(1882-1884)Cac>Tac	p.H628Y	SPG11_ENST00000427534.2_Missense_Mutation_p.H628Y|SPG11_ENST00000559193.1_Missense_Mutation_p.H628Y|SPG11_ENST00000535302.2_Missense_Mutation_p.H628Y|SPG11_ENST00000558319.1_Missense_Mutation_p.H628Y	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	628					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCTTCAGTGTGAATGAAAAGC	0.398000													40	81					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55794837	55794837	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:55794837C>T	ENST00000379665.2	+	1	624	c.525C>T	c.(523-525)ttC>ttT	p.F175F		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						TTGACCATTTCATCTGTGATT	0.438000													126	201					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29056048	29056048	+	Missense_Mutation	SNP	C	C	T	rs141527621		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:29056048C>T	ENST00000257189.4	+	16	2908	c.2825C>T	c.(2824-2826)tCc>tTc	p.S942F		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	942					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding	p.S942F(1)		breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCTTCTGGTTCCCTCGTGCAA	0.507000													68	100					0	0	1	0	0
IFRD1	3475	broad.mit.edu	37	7	112112351	112112351	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:112112351C>T	ENST00000403825.3	+	10	1380	c.1119C>T	c.(1117-1119)acC>acT	p.T373T	IFRD1_ENST00000535603.1_Silent_p.T323T|IFRD1_ENST00000005558.4_Silent_p.T373T	NM_001550.3	NP_001541.2	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	373					multicellular organismal development|myoblast cell fate determination		binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|urinary_tract(1)	15						AAAAACACACCTATGACACCT	0.398000													45	89					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875138	247875138	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:247875138C>T	ENST00000302084.2	-	1	967	c.920G>A	c.(919-921)gGa>gAa	p.G307E	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GATTTATTTTCCCTTCCATTT	0.423000													110	73					0	0	1	0	0
TRBV5-5	28610	broad.mit.edu	37	7	142149136	142149136	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:142149136G>A	ENST00000390372.3	-	0	141																											TGTGCCCAGAGATAGGAGAGC	0.517000													51	74					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52789588	52789588	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:52789588G>A	ENST00000216862.3	-	2	702	c.309C>T	c.(307-309)tcC>tcT	p.S103S	CYP24A1_ENST00000395955.3_Silent_p.S103S	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	103					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CCGACTCAAAGGAACCCAACT	0.637000													47	69					0	0	1	0	0
COX18	285521	broad.mit.edu	37	4	73923904	73923904	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:73923904G>A	ENST00000295890.4	-	6	1020	c.929C>T	c.(928-930)aCc>aTc	p.T310I	COX18_ENST00000507544.2_Missense_Mutation_p.T311I	NM_173827.2	NP_776188.1	Q8N8Q8	COX18_HUMAN	COX18 cytochrome C oxidase assembly factor	310					protein insertion into mitochondrial membrane|respiratory chain complex IV assembly	integral to mitochondrial inner membrane	protein transporter activity			large_intestine(4)|lung(2)	6	Breast(15;0.00096)		Epithelial(6;1.26e-06)|OV - Ovarian serous cystadenocarcinoma(6;9.45e-06)|all cancers(17;2.05e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATCTGACTTGGTCGATGGTAT	0.388000													51	108					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109849469	109849469	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:109849469C>T	ENST00000357155.1	-	1	194	c.145_splice	c.e1+1	p.E49_splice	MYBPHL_ENST00000477962.1_5'UTR	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	49	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CATGGGTCACCTTCTATAGGG	0.647000													11	31					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49764870	49764870	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:49764870C>T	ENST00000561648.1	-	3	142	c.89G>A	c.(88-90)gGa>gAa	p.G30E	ZNF423_ENST00000562871.1_5'UTR|ZNF423_ENST00000562520.1_5'UTR|ZNF423_ENST00000262383.2_Missense_Mutation_p.G30E|ZNF423_ENST00000563137.2_5'UTR	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	30					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CTCTGGCTCTCCTTCTAGGCC	0.488000													84	131					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3242264	3242264	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:3242264C>T	ENST00000217939.6	-	5	1616	c.1462G>A	c.(1462-1464)Gat>Aat	p.D488N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	488	Ig-like C2-type 1.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACAGTCTGATCTCTTTGCACA	0.507000													107	33					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88478526	88478526	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:88478526T>A	ENST00000552810.1	-	35	4884	c.4541A>T	c.(4540-4542)gAa>gTa	p.E1514V	CEP290_ENST00000309041.7_Missense_Mutation_p.E1516V|CEP290_ENST00000397838.3_Missense_Mutation_p.E574V|CEP290_ENST00000547691.2_Missense_Mutation_p.E574V	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1514					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						CTTTTCTCTTTCTGCAGTGGC	0.393000													46	56					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55826535	55826535	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:55826535G>A	ENST00000373965.2	-	19	2617	c.2223C>T	c.(2221-2223)gcC>gcT	p.A741A	PCDH15_ENST00000373957.3_Silent_p.A712A|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Silent_p.A734A|PCDH15_ENST00000437009.1_Silent_p.A663A|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000414778.1_Silent_p.A739A|PCDH15_ENST00000395438.1_Silent_p.A734A|PCDH15_ENST00000320301.6_Silent_p.A734A|PCDH15_ENST00000373955.1_Silent_p.A734A|PCDH15_ENST00000395432.2_Silent_p.A697A|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Silent_p.A734A|PCDH15_ENST00000409834.1_Silent_p.A345A|PCDH15_ENST00000395445.1_Silent_p.A741A|PCDH15_ENST00000395433.1_Silent_p.A712A	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	734	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GACCCACAAAGGCATTGGCTT	0.333000										HNSCC(58;0.16)			25	59					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79324609	79324609	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:79324609G>A	ENST00000419573.3	-	7	1282	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	RASGRF1_ENST00000558480.2_Silent_p.F336F|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	336	DH.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GGTTGCGGACGAACTCTTGGT	0.587000													23	29					0	0	1	0	0
NCR3	259197	broad.mit.edu	37	6	31557874	31557874	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:31557874G>A	ENST00000376073.4	-	2	336	c.73C>T	c.(73-75)Cct>Tct	p.P25S	NCR3_ENST00000376071.4_Missense_Mutation_p.P25S|NCR3_ENST00000376072.3_Missense_Mutation_p.P25S|NCR3_ENST00000340027.5_Missense_Mutation_p.P25S|NCR3_ENST00000491161.1_5'UTR	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	25	Ig-like.				cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						CGAATCTCAGGGGGCTGGGAC	0.572000													27	23					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73836020	73836020	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:73836020C>T	ENST00000207549.4	-	12	1334	c.955G>A	c.(955-957)Gga>Aga	p.G319R	UNC13D_ENST00000587504.1_5'UTR|UNC13D_ENST00000412096.2_Missense_Mutation_p.G319R	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	319	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GAGGTGCTTCCCGCCTGAGGG	0.667000									Familial Hemophagocytic Lymphohistiocytosis				32	47					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196438154	196438154	+	Silent	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:196438154T>C	ENST00000367433.5	-	6	530	c.429A>G	c.(427-429)gaA>gaG	p.E143E	KCNT2_ENST00000294725.8_Silent_p.E143E|KCNT2_ENST00000451324.2_5'UTR|KCNT2_ENST00000367431.4_Silent_p.E143E			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	143						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CATTAATTATTTCCAAGATGA	0.303000													17	17					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169642892	169642892	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:169642892G>A	ENST00000428432.2	+	5	647	c.258G>A	c.(256-258)agG>agA	p.R86R	SAMD7_ENST00000335556.3_Silent_p.R86R	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	86										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TGGCCAGAAGGAATGAAATGA	0.358000													18	42					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95604014	95604014	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:95604014G>A	ENST00000343958.4	-	2	1269	c.1046C>T	c.(1045-1047)tCc>tTc	p.S349F	FGD6_ENST00000546711.1_Missense_Mutation_p.S349F|FGD6_ENST00000549499.1_Missense_Mutation_p.S349F	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	349	Poly-Ser.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						AGTAAGACAGGAAGAGCTACT	0.403000													54	97					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44377703	44377703	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:44377703C>T	ENST00000587539.1	-	3	662	c.663G>A	c.(661-663)ggG>ggA	p.G221G	ZNF404_ENST00000324394.6_Silent_p.G219G	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				TAAAAGCCTTCCCGCATTGCT	0.378000													68	89					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121980431	121980431	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:121980431C>T	ENST00000498619.1	+	4	987	c.549C>T	c.(547-549)ttC>ttT	p.F183F	CASR_ENST00000490131.1_Silent_p.F183F|CASR_ENST00000296154.5_Silent_p.F183F	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	183					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TCAAGTCTTTCCTCCGAACCA	0.512000													89	145					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82372829	82372829	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:82372829G>A	ENST00000370728.1	+	6	846	c.201G>A	c.(199-201)acG>acA	p.T67T	LPHN2_ENST00000319517.6_Silent_p.T67T|LPHN2_ENST00000370723.1_Silent_p.T67T|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000370721.1_Silent_p.T67T|LPHN2_ENST00000370730.1_Silent_p.T67T|LPHN2_ENST00000370717.2_Silent_p.T67T|LPHN2_ENST00000370725.1_Silent_p.T67T|LPHN2_ENST00000370727.1_Silent_p.T67T|LPHN2_ENST00000370715.1_Silent_p.T67T|LPHN2_ENST00000359929.3_Silent_p.T67T|LPHN2_ENST00000394879.1_Silent_p.T67T|LPHN2_ENST00000335786.5_Silent_p.T67T|LPHN2_ENST00000370713.1_Silent_p.T67T|LPHN2_ENST00000271029.4_Silent_p.T67T			O95490	LPHN2_HUMAN	latrophilin 2	67	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATGGTCGGACGGATGACAAGA	0.453000													55	90					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60687680	60687680	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:60687680C>T	ENST00000335712.6	-	4	2594	c.2367G>A	c.(2365-2367)atG>atA	p.M789I	BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Missense_Mutation_p.M755I|BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000356842.4_Intron|BCL11A_ENST00000358510.4_Missense_Mutation_p.M755I|BCL11A_ENST00000359629.5_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	789					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CATGCGTTTTCATGTGCCTGG	0.488000			T	IGH@	B-CLL								50	99					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57548144	57548144	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:57548144C>T	ENST00000243077.3	+	7	1461	c.995C>T	c.(994-996)cCt>cTt	p.P332L	LRP1_ENST00000554174.1_Missense_Mutation_p.P332L	NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	332					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCCCTGGACCCTGCCATGGGG	0.557000													18	44					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24813339	24813339	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:24813339C>T	ENST00000376451.2	+	8	1853	c.1593C>T	c.(1591-1593)gtC>gtT	p.V531V	KIAA1217_ENST00000430453.2_Intron|KIAA1217_ENST00000376454.3_Silent_p.V848V|KIAA1217_ENST00000376462.1_Silent_p.V768V|KIAA1217_ENST00000458595.1_Silent_p.V813V|KIAA1217_ENST00000396446.1_Silent_p.V531V|KIAA1217_ENST00000307544.6_Silent_p.V531V|KIAA1217_ENST00000396445.1_Silent_p.V531V|KIAA1217_ENST00000376452.3_Silent_p.V813V			Q5T5P2	SKT_HUMAN	KIAA1217	848					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CCGCAGAAGTCCTGAAGAGTC	0.607000													40	65					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60521106	60521106	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:60521106C>T	ENST00000371201.3	-	3	219	c.112G>A	c.(112-114)Gag>Aag	p.E38K	C1orf87_ENST00000450089.2_Missense_Mutation_p.E38K	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	38							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CTGTCATTCTCCTTGCTGTGA	0.423000													51	68					0	0	1	0	0
USP13	8975	broad.mit.edu	37	3	179478950	179478950	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:179478950C>T	ENST00000263966.3	+	17	2470	c.1999C>T	c.(1999-2001)Ccg>Tcg	p.P667S	USP13_ENST00000496897.1_Missense_Mutation_p.P602S	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	667	UBA 1.				ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			GATGGGTTTCCCGCTGGAAGC	0.512000													56	88					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12120836	12120836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:12120836C>T	ENST00000379388.2	+	4	1140	c.808C>T	c.(808-810)Cag>Tag	p.Q270*		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	270					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GTCTGCTGCTCAGAAGAATGA	0.428000													171	102					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140784075	140784075	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:140784075C>T	ENST00000573521.1	+	1	1556	c.1556C>T	c.(1555-1557)tCc>tTc	p.S519F	PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCTGTGCTCCTTTGACTAT	0.463000													27	42					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29911150	29911150	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:29911150T>C	ENST00000396634.1	+	5	790	c.449T>C	c.(448-450)cTg>cCg	p.L150P	HLA-A_ENST00000376806.5_Missense_Mutation_p.L150P|HLA-A_ENST00000376802.2_Missense_Mutation_p.L150P|HLA-A_ENST00000376809.5_Missense_Mutation_p.L150P			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	150	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TACATCGCCCTGAACGAGGAC	0.647000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			16	8					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96748641	96748641	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:96748641G>A	ENST00000260682.6	+	9	1341	c.1329G>A	c.(1327-1329)atG>atA	p.M443I		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	443					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TGGCCGGCATGGAGCTGTTTT	0.448000													76	132					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140221789	140221789	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:140221789C>T	ENST00000275884.6	-	17	3194	c.2777G>A	c.(2776-2778)aGa>aAa	p.R926K	DENND2A_ENST00000496613.1_Missense_Mutation_p.R926K|DENND2A_ENST00000537639.1_Missense_Mutation_p.R926K			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	926	dDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					CTGCAGGGTTCTCTCCTCACG	0.577000													25	47					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55175832	55175832	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:55175832C>T	ENST00000391736.1	+	6	866	c.551C>T	c.(550-552)cCt>cTt	p.P184L	LILRB4_ENST00000391733.3_Missense_Mutation_p.P184L|LILRB4_ENST00000391734.3_Missense_Mutation_p.P184L|LILRB4_ENST00000270452.2_Missense_Mutation_p.P184L|LILRB4_ENST00000430952.2_Missense_Mutation_p.P184L	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	184	Ig-like C2-type 2.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CCCATGAGTCCTGTGACCTCA	0.592000													57	92					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925140	27925140	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:27925140G>A	ENST00000244623.1	+	1	122	c.122G>A	c.(121-123)gGc>gAc	p.G41D		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ACCATCTTTGGCAATCTGACC	0.428000													52	151					0	0	1	0	0
PCMTD2	55251	broad.mit.edu	37	20	62904828	62904828	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:62904828G>A	ENST00000308824.6	+	6	1088	c.961G>A	c.(961-963)Gaa>Aaa	p.E321K	PCMTD2_ENST00000369758.3_Missense_Mutation_p.E294K|PCMTD2_ENST00000266078.6_Missense_Mutation_p.E97K|PCMTD2_ENST00000299468.7_Intron	NM_018257.2	NP_060727.2	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	321						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(9)|upper_aerodigestive_tract(1)	17	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					ACGGAGGGAAGAAGAAGAGAA	0.517000													62	105					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216371	55216371	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:55216371G>A	ENST00000340465.2	+	5	777	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	231						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCAAAATGATGAATTATGCAG	0.418000													30	15					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529119	5529119	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:5529119C>T	ENST00000311659.4	-	2	1817	c.1670G>A	c.(1669-1671)gGa>gAa	p.G557E	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	557										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTATACCTCCTGCCACACT	0.562000													34	51					0	0	1	0	0
POP1	10940	broad.mit.edu	37	8	99142284	99142284	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:99142284A>G	ENST00000401707.2	+	5	646	c.565A>G	c.(565-567)Acg>Gcg	p.T189A	POP1_ENST00000349693.3_Missense_Mutation_p.T189A	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	189					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CATGAACCGGACGCTAGAATT	0.423000													63	71					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112934	248112934	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:248112934C>T	ENST00000357191.3	+	1	775	c.775C>T	c.(775-777)Cta>Tta	p.L259L	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CTACACTTATCTACGTCCAAG	0.483000													76	155					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84533292	84533292	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:84533292C>T	ENST00000527857.1	+	0	3314					NR_026851.1																						GACTTTTCTGCCCCCCACATA	0.502000													6	13					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39284091	39284091	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:39284091C>A	ENST00000373229.5	-	5	802	c.789G>T	c.(787-789)caG>caT	p.Q263H	KCNK16_ENST00000425054.2_Intron|KCNK16_ENST00000437525.2_Missense_Mutation_p.Q263H|KCNK16_ENST00000507712.1_Intron|KCNK16_ENST00000373227.4_Intron	NM_032115.3	NP_115491.1	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	263						integral to membrane	potassium channel activity|voltage-gated ion channel activity			large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)	13						GCAGCCAGAGCTGGCAGCATC	0.662000													6	5					0.000274275	0.000275582	1	1	0
OR6F1	343169	broad.mit.edu	37	1	247875320	247875320	+	Silent	SNP	G	G	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:247875320G>C	ENST00000302084.2	-	1	785	c.738C>G	c.(736-738)acC>acG	p.T246T	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAGCACCACGGTGAGATGCG	0.532000													128	93					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19571831	19571831	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:19571831C>T	ENST00000507958.1	-	10	2100	c.1110G>A	c.(1108-1110)ctG>ctA	p.L370L	CDH18_ENST00000506372.1_Silent_p.L370L|CDH18_ENST00000511273.1_Silent_p.L370L|CDH18_ENST00000502796.1_Silent_p.L370L|CDH18_ENST00000274170.4_Silent_p.L370L|CDH18_ENST00000382275.1_Silent_p.L370L			Q13634	CAD18_HUMAN	cadherin 18, type 2	370	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CAATGATCTTCAGCATAGTAG	0.408000													39	55					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73269889	73269889	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:73269889G>A	ENST00000224721.6	+	3	201	c.196G>A	c.(196-198)Gtg>Atg	p.V66M	CDH23_ENST00000398809.4_Missense_Mutation_p.V66M|CDH23-AS1_ENST00000428918.1_RNA|CDH23_ENST00000398842.3_Missense_Mutation_p.V66M|CDH23_ENST00000461841.3_Missense_Mutation_p.V111M|CDH23_ENST00000299366.7_Missense_Mutation_p.V111M	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	66	Cadherin 1.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						TGACCCCCTGGTGTTTGGCGT	0.572000													42	73					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1426872	1426872	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:1426872G>A	ENST00000345913.4	+	3	241	c.150G>A	c.(148-150)gtG>gtA	p.V50V	TPO_ENST00000329066.4_Silent_p.V50V|TPO_ENST00000337415.3_Silent_p.V50V|TPO_ENST00000382201.3_Silent_p.V50V|TPO_ENST00000346956.3_Silent_p.V50V|TPO_ENST00000349624.3_Silent_p.V50V|TPO_ENST00000497517.2_Intron|TPO_ENST00000382269.3_Silent_p.V50V|TPO_ENST00000539820.1_Silent_p.V50V|TPO_ENST00000382198.1_Silent_p.V50V	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	50					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AGCGCCTGGTGGACACCGCCA	0.592000													20	40					0	0	1	0	0
CXCL12	6387	broad.mit.edu	37	10	44876285	44876285	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:44876285G>A	ENST00000374429.2	-	2	191	c.105C>T	c.(103-105)ttC>ttT	p.F35F	CXCL12_ENST00000395793.3_Silent_p.F35F|AL137026.1_ENST00000593376.1_Intron|CXCL12_ENST00000374426.2_Silent_p.F35F|CXCL12_ENST00000496375.1_5'UTR|CXCL12_ENST00000343575.6_Silent_p.F35F|CXCL12_ENST00000395795.4_Silent_p.F35F|CXCL12_ENST00000395794.2_Silent_p.F35F	NM_000609.5|NM_001277990.1	NP_000600.1|NP_001264919.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	35					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	CATGGCTTTCGAAGAATCGGC	0.463000													88	143					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756416	248756416	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:248756416G>A	ENST00000330500.2	-	1	684	c.654C>T	c.(652-654)taC>taT	p.Y218Y		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGATATAGTAGTAAGACACTG	0.458000													70	58					0	0	1	0	0
STRIP1	85369	broad.mit.edu	37	1	110596512	110596512	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:110596512C>T	ENST00000369795.3	+	21	2514	c.2492C>T	c.(2491-2493)tCc>tTc	p.S831F	STRIP1_ENST00000369796.1_Missense_Mutation_p.S736F	NM_033088.2	NP_149079.2			striatin interacting protein 1																		AAGCCCATTTCCTGGGAAGAG	0.527000											OREG0013647	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	33					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435975	158435975	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:158435975C>T	ENST00000289451.2	+	1	704	c.624C>T	c.(622-624)gtC>gtT	p.V208V		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TTGCCTTGGTCATTCCTCTGC	0.473000													135	110					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48805978	48805978	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:48805978G>A	ENST00000315396.7	-	10	1784	c.1102C>T	c.(1102-1104)Cgg>Tgg	p.R368W		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	368										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		AGCTGTCCCCGCACATCCTGG	0.647000													4	98					0	0	1	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010865	59010865	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:59010865G>A	ENST00000263093.2	-	7	1770	c.1661C>T	c.(1660-1662)aCc>aTc	p.T554I	SLC27A5_ENST00000601355.1_Missense_Mutation_p.T470I	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	554					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity	p.T554I(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GGACCGGAAGGTGTCCCCGAG	0.657000													31	36					0	0	1	0	0
SIKE1	80143	broad.mit.edu	37	1	115321893	115321893	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:115321893G>A	ENST00000369528.5	-	3	367	c.290C>T	c.(289-291)tCc>tTc	p.S97F	SIKE1_ENST00000506320.1_5'UTR|SIKE1_ENST00000060969.5_Missense_Mutation_p.S93F	NM_001102396.1|NM_025073.2	NP_001095866.1|NP_079349.2	Q9BRV8	SIKE1_HUMAN	suppressor of IKBKE 1	93						cytosol	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6						TTCCTCCAAGGAAATCCATAG	0.388000													77	53					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160999567	160999567	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:160999567G>A	ENST00000447678.1	-	28	4579	c.4459C>T	c.(4459-4461)Cct>Tct	p.P1487S	LPA_ENST00000316300.5_Missense_Mutation_p.P1487S	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3995	Kringle 13.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGTTCAGAAGGAGCCTCTGTG	0.483000													53	24					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110986192	110986192	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:110986192G>A	ENST00000524391.1	-	2	1458	c.426C>T	c.(424-426)atC>atT	p.I142I	KCNV1_ENST00000297404.1_Silent_p.I142I|RP11-696P8.2_ENST00000530667.1_RNA			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	142						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TGAGCTCATCGATGCCCCAGT	0.652000													41	26					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10450912	10450912	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:10450912C>T	ENST00000245503.5	-	4	612	c.228G>A	c.(226-228)caG>caA	p.Q76Q	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.Q76Q|MYH2_ENST00000532183.1_Silent_p.Q76Q	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	76	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TGGGGAAGACCTGATCATCCT	0.418000													85	178					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210574681	210574681	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:210574681A>G	ENST00000360351.4	+	12	5282	c.4776A>G	c.(4774-4776)acA>acG	p.T1592T	MAP2_ENST00000392194.1_Silent_p.T236T|MAP2_ENST00000361559.4_Silent_p.T236T|MAP2_ENST00000447185.1_Silent_p.T1588T|MAP2_ENST00000199940.6_Silent_p.T293T|MAP2_ENST00000475600.1_3'UTR	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1592					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GTACCTCAACACCCACTACCC	0.527000													43	85					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120387881	120387881	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:120387881G>A	ENST00000331113.4	+	6	2827	c.1862G>A	c.(1861-1863)gGa>gAa	p.G621E	RP4-797C5.2_ENST00000450480.1_RNA	NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	621					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GAGTACTCAGGAGGAAATATT	0.423000													16	40					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42281764	42281764	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:42281764G>A	ENST00000282030.5	+	2	749	c.453G>A	c.(451-453)acG>acA	p.T151T	SETBP1_ENST00000426838.4_Silent_p.T151T	NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	151						nucleus	DNA binding	p.T97T(1)|p.T151T(1)		NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCAAAGCCACGAAGGAGGAAG	0.428000									Schinzel-Giedion syndrome				32	48					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72350659	72350659	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:72350659G>A	ENST00000389916.4	+	18	2805	c.2667G>A	c.(2665-2667)agG>agA	p.R889R		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	889					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CAAAGAGAAGGAAGCGGAGGT	0.657000													3	12					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4294650	4294650	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:4294650C>T	ENST00000301272.2	-	4	521	c.476G>A	c.(475-477)gGa>gAa	p.G159E	TMIGD2_ENST00000600349.1_Intron|TMIGD2_ENST00000600114.1_Missense_Mutation_p.G39E|TMIGD2_ENST00000595645.1_Missense_Mutation_p.G159E	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	159						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCATGCTTCCCACCCCCAG	0.632000													182	257					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2830745	2830745	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:2830745C>T	ENST00000602557.1	-	58	9375	c.8820G>A	c.(8818-8820)aaG>aaA	p.K2940K	CSMD1_ENST00000537824.1_Silent_p.K2939K|CSMD1_ENST00000520002.1_Silent_p.K2940K|CSMD1_ENST00000602723.1_Silent_p.K2882K|CSMD1_ENST00000400186.3_Silent_p.K2882K|CSMD1_ENST00000542608.1_Silent_p.K2881K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2940	Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGAGAAGACTCTTTGTCTTAA	0.532000													75	120					0	0	1	0	0
OR52K2	119774	broad.mit.edu	37	11	4471058	4471058	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:4471058C>T	ENST00000325719.4	+	1	534	c.489C>T	c.(487-489)ttC>ttT	p.F163F		NM_001005172.2	NP_001005172.2	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K, member 2	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|skin(6)	25		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACTCCCCTTCCTGCTGAGAT	0.577000													64	93					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7252557	7252557	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:7252557C>T	ENST00000266542.4	-	4	648	c.556G>A	c.(556-558)Gac>Aac	p.D186N	C1RL_ENST00000544702.1_Missense_Mutation_p.D186N|C1RL_ENST00000545280.1_Missense_Mutation_p.D70N	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	186					complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GCAGGGTTGTCTCCAGGTGCG	0.597000													21	29					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21788257	21788257	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:21788257G>A	ENST00000328843.6	+	53	8622	c.8591G>A	c.(8590-8592)gGg>gAg	p.G2864E	DNAH11_ENST00000409508.3_Missense_Mutation_p.G2857E			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2864	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GTTGGAGTTGGGGGCAGTGGC	0.542000									Kartagener syndrome				28	46					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183109539	183109539	+	Splice_Site	SNP	G	G	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:183109539G>T	ENST00000258341.4	+	27	4731	c.4473_splice	c.e27-1	p.A1492_splice	RP11-181K3.4_ENST00000457852.2_RNA	NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	1492	Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCCCTTACAGGCTTCACAGGC	0.408000													23	65					6.44725e-10	6.49656e-10	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20493408	20493408	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:20493408C>T	ENST00000504154.1	+	9	1052	c.800C>T	c.(799-801)tCt>tTt	p.S267F	SLIT2_ENST00000503823.1_Missense_Mutation_p.S267F|SLIT2_ENST00000503837.1_Missense_Mutation_p.S271F|SLIT2_ENST00000273739.5_Missense_Mutation_p.S271F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	267	LRRNT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATGGCTCCTTCTTGTAGTGTT	0.413000													79	120					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50763781	50763781	+	Missense_Mutation	SNP	C	C	T	rs41450053		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:50763781C>T	ENST00000300589.2	+	11	3124	c.3019C>T	c.(3019-3021)Ctt>Ttt	p.L1007F		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	1007					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CCTGCAGGCCCTTGAAAGGAA	0.493000													22	38					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53539339	53539339	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:53539339A>G	ENST00000357758.3	-	6	1662	c.1479T>C	c.(1477-1479)taT>taC	p.Y493Y	DDHD1_ENST00000323669.5_Silent_p.Y493Y|DDHD1_ENST00000395606.1_Silent_p.Y500Y	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	493					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					GTGGACTAGTATAATACATTA	0.328000													19	34					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180041160	180041160	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:180041160C>T	ENST00000261937.6	-	24	3317	c.3239G>A	c.(3238-3240)tGg>tAg	p.W1080*	FLT4_ENST00000393347.3_Nonsense_Mutation_p.W1080*|FLT4_ENST00000502649.1_Nonsense_Mutation_p.W1080*	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1080	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGGGGCCATCCACTTCAGGGG	0.617000													42	64					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189854121	189854121	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:189854121G>A	ENST00000304636.3	+	8	806		c.e8-1		COL3A1_ENST00000317840.5_Splice_Site	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1						axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTTATTTTCAGGGCCCTCCAG	0.333000													12	16					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84562916	84562916	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:84562916C>T	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							TAAATCTTTCCATATGAGGAT	0.413000													5	8					0	0	1	0	0
IGHA1	3493	broad.mit.edu	37	14	106173680	106173680	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:106173680C>T	ENST00000390547.2	-	0	886																											GCGCAGTATGCTGGTCACAGC	0.662000													5	140					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049655	9049655	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:9049655G>A	ENST00000397910.4	-	5	32179	c.31976C>T	c.(31975-31977)tCg>tTg	p.S10659L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10661	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATCTGTCCCCGAAATAGTGAC	0.498000													41	55					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79682555	79682555	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:79682555C>T	ENST00000331531.5	+	3	381	c.261C>T	c.(259-261)gaC>gaT	p.D87D	SLC25A10_ENST00000571730.1_Silent_p.D242D|SLC25A10_ENST00000350690.5_Silent_p.D87D|SLC25A10_ENST00000541223.1_Silent_p.D242D|SLC25A10_ENST00000545862.1_Silent_p.D44D	NM_001270888.1	NP_001257817.1	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	87					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	CTGTGCGGGACCGTGTGGCCA	0.701000													147	249					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43820995	43820995	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:43820995C>T	ENST00000382031.1	+	5	8069	c.8038C>T	c.(8038-8040)Cgg>Tgg	p.R2680W	MAP1A_ENST00000399453.1_Missense_Mutation_p.R2442W|MAP1A_ENST00000300231.5_Missense_Mutation_p.R2442W			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2442						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CACTGAGCCTCGGCCCCATCG	0.647000													29	53					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47282765	47282765	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:47282765G>C	ENST00000271153.4	+	9	1152	c.1116G>C	c.(1114-1116)gaG>gaC	p.E372D	CYP4B1_ENST00000452782.2_Missense_Mutation_p.E210D|CYP4B1_ENST00000371919.4_Missense_Mutation_p.E358D|CYP4B1_ENST00000371923.4_Missense_Mutation_p.E373D			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	372					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					GCATCAAGGAGAGCTTCCGCC	0.552000													51	82					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43893730	43893730	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:43893730C>T	ENST00000450892.2	-	24	4642	c.4565G>A	c.(4564-4566)gGa>gAa	p.G1522E	STRC_ENST00000541030.1_Missense_Mutation_p.G749E	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1522					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		AGGACGAAATCCCCGGGGGGG	0.532000													28	64					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686274	54686274	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:54686274G>A	ENST00000540264.2	-	2	1515	c.1006C>T	c.(1006-1008)Cac>Tac	p.H336Y	RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000435572.2_Missense_Mutation_p.H336Y|NFE2_ENST00000312156.4_Missense_Mutation_p.H336Y|NFE2_ENST00000553070.1_Missense_Mutation_p.H336Y			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	336	Leucine-zipper.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						TCCCGAAGGTGCTGGAAAATG	0.607000													39	74					0	0	1	0	0
NPIPB15	440348	broad.mit.edu	37	16	74425426	74425426	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:74425426C>T	ENST00000429990.1	+	7	876	c.780C>T	c.(778-780)tcC>tcT	p.S260S						nuclear pore complex interacting protein family, member B15																		CTGATAACTCCCTGAGCCTCA	0.517000													21	295					0	0	1	0	0
CCNL1	57018	broad.mit.edu	37	3	156868170	156868170	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:156868170C>T	ENST00000295926.3	-	6	793	c.674_splice	c.e6-1	p.W225_splice	CCNL1_ENST00000461804.1_Splice_Site_p.W225_splice|CCNL1_ENST00000479052.1_5'UTR	NM_020307.2	NP_064703.1	Q9UK58	CCNL1_HUMAN	cyclin L1	225	Cyclin-like 2.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			NS(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			TCATGTAATTCCTGAAAAATA	0.358000													11	25					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603892	140603892	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:140603892G>A	ENST00000239449.4	+	1	815	c.815G>A	c.(814-816)gGa>gAa	p.G272E	PCDHB14_ENST00000515856.2_Missense_Mutation_p.G119E	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		272	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGATGCAGGAAACTATGGA	0.428000													32	65					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173027	51173027	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:51173027G>A	ENST00000440970.1	-	2	3246	c.2815C>T	c.(2815-2817)Cgt>Tgt	p.R939C	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.R1036C	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1036					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GAAAAGCCACGATTGCAAACT	0.448000													31	53					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154007527	154007527	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:154007527G>A	ENST00000496811.1	-	16	1983	c.1903C>T	c.(1903-1905)Cct>Tct	p.P635S	DHX36_ENST00000544526.1_Missense_Mutation_p.P621S|DHX36_ENST00000329463.5_Missense_Mutation_p.P621S|DHX36_ENST00000308361.6_Missense_Mutation_p.P635S	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	635	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TCTTCCAAAGGAGTTCTCAAA	0.328000													21	36					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48494828	48494828	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:48494828C>T	ENST00000435803.1	+	43	12784	c.12760C>T	c.(12760-12762)Cct>Tct	p.P4254S	ABCA13_ENST00000544596.1_Missense_Mutation_p.P14S	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4254					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CACCGAGTACCCTCCCCTCAG	0.572000													6	9					0	0	1	0	0
WDR24	84219	broad.mit.edu	37	16	737047	737047	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:737047G>A	ENST00000293883.4	-	3	1788	c.1029C>T	c.(1027-1029)ctC>ctT	p.L343L	WDR24_ENST00000248142.6_Silent_p.L473L	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	473										breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				GGCCGTAGCAGAGGCCCTCAG	0.706000													12	16					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61040905	61040905	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:61040905C>T	ENST00000252997.2	-	5	959	c.898G>A	c.(898-900)Gcc>Acc	p.A300T		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	300					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			GAGCCCCTGGCCTTGGCGATG	0.652000													5	11					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55086420	55086420	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:55086420C>T	ENST00000251377.3	+	5	708	c.575C>T	c.(574-576)tCg>tTg	p.S192L	LILRA2_ENST00000391737.1_Missense_Mutation_p.S180L|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.S192L|LILRA2_ENST00000251376.3_Missense_Mutation_p.S192L|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2									p.S192L(1)		breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CGCAGGTGGTCGTACAGGTGC	0.572000													82	109					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48456735	48456735	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:48456735G>A	ENST00000358536.4	-	20	4085	c.3816C>T	c.(3814-3816)gtC>gtT	p.V1272V	PLXNB1_ENST00000465117.1_5'UTR|PLXNB1_ENST00000296440.6_Silent_p.V1272V|PLXNB1_ENST00000456774.1_Silent_p.V1089V|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000358459.4_Silent_p.V1089V	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1272	IPT/TIG 3.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCTGGCCACGGACGCATATCT	0.587000													24	32					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17375083	17375083	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:17375083C>T	ENST00000252597.3	-	2	199	c.26G>A	c.(25-27)cGa>cAa	p.R9Q	USHBP1_ENST00000598570.1_5'UTR|USHBP1_ENST00000431146.2_5'UTR	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	9							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						TCGCCGGCTTCGGGGCCGCGT	0.637000													17	32					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91628405	91628405	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:91628405C>T	ENST00000375835.4	-	12	2048	c.1742G>A	c.(1741-1743)gGg>gAg	p.G581E		NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	581	SH2.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						CAGCTCACTCCCTGCAGAGAC	0.562000													44	66					0	0	1	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47650740	47650740	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:47650740C>T	ENST00000294338.2	-	3	328	c.206G>A	c.(205-207)gGa>gAa	p.G69E	PDZK1IP1_ENST00000371885.1_Missense_Mutation_p.G69E|PDZK1IP1_ENST00000491793.1_5'UTR	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	69						integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						TGCCTTGTTTCCGACGGTCAG	0.612000													32	72					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72292479	72292479	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:72292479G>A	ENST00000263563.6	+	6	1004	c.736G>A	c.(736-738)Gac>Aac	p.D246N		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		TGGTGAGGACGACTTGCATGT	0.622000													71	120					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861061	55861061	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:55861061C>T	ENST00000302124.2	+	1	309	c.278C>T	c.(277-279)tCc>tTc	p.S93F	OR8I2_ENST00000560768.1_Missense_Mutation_p.S93F			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S93C(1)		NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					AGATCCATCTCCTTTGTTGGC	0.388000													86	143					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56952656	56952656	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:56952656G>A	ENST00000504904.3	-	7	2427	c.1708C>T	c.(1708-1710)Ctt>Ttt	p.L570F	ZNF667_ENST00000342634.3_Missense_Mutation_p.L698F|ZNF667_ENST00000292069.6_Missense_Mutation_p.L570F|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TGTCGAATAAGGTCTGAGCCA	0.413000													69	107					0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88535191	88535191	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:88535191C>T	ENST00000399271.1	+	5	1497	c.1377C>T	c.(1375-1377)tcC>tcT	p.S459S	RP11-742B18.1_ENST00000506480.1_RNA|DSPP_ENST00000282478.7_Silent_p.S459S	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	459	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		ATGATAAGTCCATGCAAGGAG	0.398000													37	59					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84697540	84697540	+	Missense_Mutation	SNP	C	C	T	rs148351346	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:84697540C>T	ENST00000284136.6	-	5	599	c.556G>A	c.(556-558)Gat>Aat	p.D186N	SEMA3D_ENST00000444867.1_Missense_Mutation_p.D186N	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	186	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TGCTGAGGATCGAAAGGACAT	0.343000													26	72					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28023495	28023495	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:28023495C>T	ENST00000375790.5	-	5	1160	c.728G>A	c.(727-729)gGa>gAa	p.G243E	MKX_ENST00000419761.1_Missense_Mutation_p.G243E			Q8IYA7	MKX_HUMAN	mohawk homeobox	243					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						CCTTGTTTTTCCCATCATGGT	0.448000													79	116					0	0	1	0	0
IDO1	3620	broad.mit.edu	37	8	39785516	39785516	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:39785516C>T	ENST00000518237.1	+	10	1663	c.1024C>T	c.(1024-1026)Ctg>Ttg	p.L342L	IDO1_ENST00000522495.1_Silent_p.L342L|RP11-44K6.3_ENST00000517623.1_RNA	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	342					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	TCTGGTCTCCCTGAGGAGCTA	0.493000													7	18					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52550583	52550583	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:52550583G>A	ENST00000321725.6	+	40	4342	c.4266G>A	c.(4264-4266)agG>agA	p.R1422R		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1422	EGF-like 10.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AGTGCCCTAGGAAGTGCGACC	0.652000													33	63					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32280897	32280897	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:32280897C>T	ENST00000360482.2	-	2	167	c.38G>A	c.(37-39)gGa>gAa	p.G13E	SPOCD1_ENST00000257100.3_Intron|SPOCD1_ENST00000373648.2_Missense_Mutation_p.G13E|SPOCD1_ENST00000533231.1_Missense_Mutation_p.G13E	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	13					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CACAGGGTCTCCTGTGCTGGG	0.597000													19	60					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66458044	66458044	+	RNA	SNP	T	T	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:66458044T>G	ENST00000424345.1	+	0	67																											GTCCTGGGCTTCGGCTGGGGC	0.682000													4	32					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753166	76753166	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:76753166C>T	ENST00000536229.3	+	1	1485	c.776C>T	c.(775-777)gCg>gTg	p.A259V	SALL3_ENST00000575389.2_Missense_Mutation_p.A392V|SALL3_ENST00000537592.2_Missense_Mutation_p.A392V			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCGCTGTCCGCGCTCATGAAG	0.642000													16	25					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61430389	61430389	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:61430389C>T	ENST00000398571.2	-	75	9470	c.9394G>A	c.(9394-9396)Gac>Aac	p.D3132N		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	3132					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TCATAAACGTCATCTTTGCCC	0.318000													26	42					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065685	9065685	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:9065685G>A	ENST00000397910.4	-	3	21964	c.21761C>T	c.(21760-21762)tCt>tTt	p.S7254F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7256	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCTCCACAGAACTGCCTGT	0.483000													90	127					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595882	179595882	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:179595882C>T	ENST00000589042.1	-	60	17734	c.17510G>A	c.(17509-17511)gGa>gAa	p.G5837E	TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G5520E|TTN_ENST00000342992.6_Missense_Mutation_p.G4593E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5520	Ig-like 39.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTGGGTCTCCTTGGGTGAC	0.448000													78	132					0	0	1	0	0
MKS1	54903	broad.mit.edu	37	17	56294094	56294094	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:56294094C>T	ENST00000393119.2	-	3	268	c.194G>A	c.(193-195)gGa>gAa	p.G65E	MKS1_ENST00000313863.6_Missense_Mutation_p.G65E|MKS1_ENST00000546108.1_5'UTR|MKS1_ENST00000337050.7_Missense_Mutation_p.G65E|MKS1_ENST00000537529.2_Missense_Mutation_p.G55E	NM_017777.3	NP_060247.2	Q9NXB0	MKS1_HUMAN	Meckel syndrome, type 1	65					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			endometrium(5)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						TGGGCGGTGTCCACCTCCAAA	0.458000													16	46					0	0	1	0	0
BAD	572	broad.mit.edu	37	11	64037604	64037604	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:64037604G>A	ENST00000544785.1	-	2	393	c.393C>T	c.(391-393)ttC>ttT	p.F131F	BAD_ENST00000394532.3_3'UTR|BAD_ENST00000309032.3_3'UTR			Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	0					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4						AGGCCTGAGGGAAGTACTTCC	0.602000													8	18					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48950608	48950608	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:48950608C>T	ENST00000294954.7	-	6	544	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	LHCGR_ENST00000405626.1_Missense_Mutation_p.E175K|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000344775.3_Missense_Mutation_p.E175K|LHCGR_ENST00000401907.1_Missense_Mutation_p.E175K|LHCGR_ENST00000403273.1_Missense_Mutation_p.E175K	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	175					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTTACAGATTCATTATTCATC	0.373000													17	37					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712329	121712329	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:121712329C>T	ENST00000273691.3	-	6	1240	c.1135G>A	c.(1135-1137)Gat>Aat	p.D379N	ILDR1_ENST00000344209.5_Missense_Mutation_p.D423N|ILDR1_ENST00000393631.1_Missense_Mutation_p.D334N|ILDR1_ENST00000462014.1_Missense_Mutation_p.D391N|ILDR1_ENST00000460554.1_5'UTR	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	423						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GAGGGGACATCGCTTAGGCTG	0.632000													33	33					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46095087	46095087	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:46095087G>A	ENST00000323040.4	-	2	982	c.38C>T	c.(37-39)tCg>tTg	p.S13L	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	13						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GTCCACGCGCGAGTCCACGTG	0.687000													35	41					0	0	1	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6530407	6530407	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:6530407C>T	ENST00000377748.1	-	17	2417	c.1920G>A	c.(1918-1920)aaG>aaA	p.K640K	PLEKHG5_ENST00000544978.1_Silent_p.K563K|PLEKHG5_ENST00000400913.1_Silent_p.K563K|PLEKHG5_ENST00000535355.1_Silent_p.K632K|PLEKHG5_ENST00000537245.1_Silent_p.K642K|PLEKHG5_ENST00000377725.1_Silent_p.K563K|PLEKHG5_ENST00000377737.2_Silent_p.K563K|PLEKHG5_ENST00000377728.3_Silent_p.K563K|PLEKHG5_ENST00000400915.3_Silent_p.K619K|PLEKHG5_ENST00000377732.1_Silent_p.K600K|PLEKHG5_ENST00000340850.5_Silent_p.K563K|PLEKHG5_ENST00000377740.3_Silent_p.K640K	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	619	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GCAGAAATTCCTTCAGGAGCT	0.642000													49	35					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101706018	101706018	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:101706018C>T	ENST00000261637.4	+	21	2690	c.2516C>T	c.(2515-2517)tCc>tTc	p.S839F		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	839					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GAGCCACGGTCCAGGGAGCTT	0.453000													56	124					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901687	51901687	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:51901687C>T	ENST00000268919.4	+	1	1449	c.1293C>T	c.(1291-1293)atC>atT	p.I431I		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	431	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TGTTCCAGATCATCCTGAAGT	0.507000													16	35					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8111539	8111539	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:8111539G>A	ENST00000379328.3	+	5	1596	c.1028G>A	c.(1027-1029)gGg>gAg	p.G343E	GATA3_ENST00000346208.3_Missense_Mutation_p.G342E|GATA3_ENST00000461472.1_3'UTR	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	342					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						AATGCCTGTGGGCTCTACTAC	0.572000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						27	45					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25297593	25297593	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:25297593G>T	ENST00000354189.5	-	9	917	c.882C>A	c.(880-882)ttC>ttA	p.F294L	CASC1_ENST00000320267.9_Missense_Mutation_p.F230L|CASC1_ENST00000395987.3_Missense_Mutation_p.F236L|CASC1_ENST00000545133.1_Missense_Mutation_p.F171L|CASC1_ENST00000557684.1_5'UTR|CASC1_ENST00000537577.1_Missense_Mutation_p.F118L|CASC1_ENST00000395990.2_Missense_Mutation_p.F190L	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	230										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			GTGTTTCAGAGAATCTAACAC	0.363000													17	36					1.15088e-07	1.15747e-07	1	1	0
AEBP1	165	broad.mit.edu	37	7	44147091	44147091	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:44147091G>A	ENST00000223357.3	+	3	954	c.649G>A	c.(649-651)Gca>Aca	p.A217T		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	217	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						CCATGTGGAGGCACGGGAGCA	0.652000													20	46					0	0	1	0	0
LCN12	286256	broad.mit.edu	37	9	139847361	139847361	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:139847361C>T	ENST00000371633.3	+	2	132	c.132C>T	c.(130-132)ttC>ttT	p.F44F		NM_178536.3	NP_848631.2	Q6JVE5	LCN12_HUMAN	lipocalin 12	44					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|kidney(1)|lung(1)|prostate(2)	5	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GGGAATGGTTCGTCCTGGGCC	0.672000													71	150					0	0	1	0	0
MPHOSPH10	10199	broad.mit.edu	37	2	71360300	71360300	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:71360300A>G	ENST00000244230.2	+	2	714	c.362A>G	c.(361-363)gAg>gGg	p.E121G	MPHOSPH10_ENST00000498451.2_Missense_Mutation_p.E121G	NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	121					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						GATGGTTCAGAGATAGAGGCT	0.423000													29	33					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101381423	101381423	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:101381423C>T	ENST00000392979.3	+	7	965	c.604C>T	c.(604-606)Cct>Tct	p.P202S	ANO4_ENST00000538618.1_3'UTR|ANO4_ENST00000392977.3_Missense_Mutation_p.P237S|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	237						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CTACACTGCCCCTTTCAGCCA	0.507000										HNSCC(74;0.22)	OREG0022059	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	79	138					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158368903	158368903	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:158368903C>T	ENST00000334438.1	-	1	353	c.354G>A	c.(352-354)gtG>gtA	p.V118V		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					CATATCCCATCACAGCAATGA	0.493000													107	83					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10874719	10874719	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:10874719C>T	ENST00000379491.4	-	5	1177	c.1030G>A	c.(1030-1032)Gaa>Aaa	p.E344K	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	344					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TTAGTCCTTTCCACAAGGCTG	0.502000													63	211					0	0	1	0	0
TPSD1	23430	broad.mit.edu	37	16	1308340	1308340	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:1308340C>T	ENST00000211076.3	+	5	840	c.692C>T	c.(691-693)tCt>tTt	p.S231F	TPSD1_ENST00000397534.2_Missense_Mutation_p.S224F	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	231	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				CAGGGTGACTCTGGAGGGCCC	0.672000													33	47					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961563	1961563	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:1961563C>T	ENST00000217305.2	-	4	396	c.171G>A	c.(169-171)gaG>gaA	p.E57E	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Silent_p.E57E|PDYN_ENST00000539905.1_Silent_p.E57E	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	57					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TCTCCCATTCCTCAGAGGGCA	0.542000													43	62					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70148333	70148333	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:70148333G>A	ENST00000335568.5	+	2	825	c.823G>A	c.(823-825)Gat>Aat	p.D275N	UGT2B28_ENST00000511240.1_Missense_Mutation_p.D275N	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	275					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	ACCAAACATTGATTTTGTTGG	0.403000													129	199					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95497824	95497824	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:95497824C>T	ENST00000432432.2	-	0	1019					NR_040113.1																						GACACTTTCTCGGGGACACAC	0.353000													86	174					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25427549	25427549	+	RNA	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:25427549A>T	ENST00000424208.1	+	0	272				SNHG14_ENST00000365306.1_RNA	NR_003305.1																						TGAGAACCTTATATTGTCCTG	0.517000													131	233					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258595	56258595	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:56258595G>A	ENST00000327216.2	-	1	276	c.252C>T	c.(250-252)ttC>ttT	p.F84F		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TCTCTGAAAGGAAAATCTCCA	0.468000													24	78					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55406938	55406938	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:55406938C>T	ENST00000398661.2	-	3	330	c.198_splice	c.e3-1	p.E67_splice	HMGCLL1_ENST00000370850.2_Splice_Site_p.E37_splice|HMGCLL1_ENST00000308161.4_Splice_Site_p.E37_splice|HMGCLL1_ENST00000274901.4_Splice_Site_p.E37_splice|HMGCLL1_ENST00000428842.1_Splice_Site_p.E37_splice|HMGCLL1_ENST00000508459.1_Splice_Site_p.E37_splice	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	67							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TGGGATGTTTCCTGAAATGCA	0.343000													12	8					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133978827	133978827	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:133978827C>T	ENST00000220616.4	+	30	5611	c.5571C>T	c.(5569-5571)tcC>tcT	p.S1857S	TG_ENST00000542445.1_Silent_p.S227S|TG_ENST00000519543.1_Silent_p.S11S|TG_ENST00000377869.1_Silent_p.S1800S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1857					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AACTTTTCTCCCCTGTGGACC	0.443000													29	104					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98742691	98742691	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:98742691C>T	ENST00000286067.2	+	1	1651	c.1544C>T	c.(1543-1545)tCc>tTc	p.S515F		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	515										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TCGGATTCTTCCTCTGCTGAC	0.388000													63	76					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105609870	105609870	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:105609870C>T	ENST00000331782.3	-	25	3593	c.3190G>A	c.(3190-3192)Gct>Act	p.A1064T	JAG2_ENST00000347004.2_Missense_Mutation_p.A1026T	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	1064					auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCGGTGACAGCCAGGAGCAGT	0.682000													4	7					0	0	1	0	0
LRRC73	221424	broad.mit.edu	37	6	43475632	43475632	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:43475632C>T	ENST00000372441.1	-	4	1489	c.589G>A	c.(589-591)Gtg>Atg	p.V197M		NM_001012974.1	NP_001012992.1	Q5JTD7	CF154_HUMAN	leucine rich repeat containing 73	197																	CTAGAGGCCACAGCTACAGCC	0.557000													3	17					0	0	1	0	0
FAM160B2	64760	broad.mit.edu	37	8	21959747	21959747	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:21959747C>T	ENST00000289921.7	+	15	1959	c.1913C>T	c.(1912-1914)cCc>cTc	p.P638L		NM_022749.5	NP_073586.5	Q86V87	F16B2_HUMAN	family with sequence similarity 160, member B2	638										endometrium(2)|kidney(1)|lung(2)|prostate(3)|urinary_tract(1)	9						TTCCCCCACCCCCATATTCAT	0.632000													30	50					0	0	1	0	0
INMT	11185	broad.mit.edu	37	7	30795057	30795057	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:30795057G>A	ENST00000013222.5	+	3	398	c.382G>A	c.(382-384)Gag>Aag	p.E128K	INMT_ENST00000484180.1_3'UTR|INMT-FAM188B_ENST00000458257.1_Intron|INMT_ENST00000409539.1_Missense_Mutation_p.E127K	NM_001199219.1|NM_006774.4	NP_001186148.1|NP_006765.4	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	128						cytoplasm	amine N-methyltransferase activity			kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|stomach(1)	23						GGAGGAGAAGGAGGAGAAGCT	0.637000													9	28					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112949	248112949	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:248112949C>T	ENST00000357191.3	+	1	790	c.790C>T	c.(790-792)Ctg>Ttg	p.L264L	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCCAAGATCCCTGCGATCTCC	0.483000													117	85					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52947285	52947285	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:52947285C>T	ENST00000371544.3	-	11	1920	c.1658G>A	c.(1657-1659)aGa>aAa	p.R553K	ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000257177.4_Missense_Mutation_p.R553K	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	553					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						GTCATCCATTCTTTTTGGGTC	0.338000													77	100					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140732067	140732067	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:140732067C>T	ENST00000523390.1	+	1	2240	c.2240C>T	c.(2239-2241)tCc>tTc	p.S747F	PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1												p.S747F(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGCCCTATTCCTACAATCTA	0.532000													65	80					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39873047	39873047	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:39873047G>A	ENST00000502986.2	+	11	1431	c.1189G>A	c.(1189-1191)Gga>Aga	p.G397R	IDO2_ENST00000389060.4_Missense_Mutation_p.G384R|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	384					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						GGGCACAGGTGGAACCGCAGT	0.537000													47	81					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307259	140307259	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:140307259A>G	ENST00000253807.2	+	1	782	c.782A>G	c.(781-783)gAt>gGt	p.D261G	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.D261G|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGATCCAGATGAAGGGTCC	0.547000													21	36					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101794107	101794107	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:101794107C>T	ENST00000506729.1	-	6	1281	c.1110G>A	c.(1108-1110)aaG>aaA	p.K370K	SLCO6A1_ENST00000379807.3_Silent_p.K370K|SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000513675.1_Intron|SLCO6A1_ENST00000389019.3_Silent_p.K308K|SLCO6A1_ENST00000379810.1_Intron			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	370						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CACATAAATCCTTGATATTAG	0.303000													41	93					0	0	1	0	0
TRAV3	28690	broad.mit.edu	37	14	22192420	22192420	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:22192420C>T	ENST00000390425.2	+	0	371																											GCCTCCAGTTCCTTCTGAAAT	0.443000													55	78					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047822	9047822	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:9047822G>A	ENST00000397910.4	-	5	34012	c.33809C>T	c.(33808-33810)cCt>cTt	p.P11270L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11272	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTCTCTGCAGGATGGGTGAC	0.488000													13	22					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45033496	45033496	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:45033496C>T	ENST00000454753.1	-	0	315							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				AGCAGGATTCCCATCCAGTGG	0.587000													17	39					0	0	1	0	0
CCNA1	8900	broad.mit.edu	37	13	37011886	37011886	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:37011886G>A	ENST00000418263.1	+	3	765	c.415G>A	c.(415-417)Gat>Aat	p.D139N	CCNA1_ENST00000255465.4_Missense_Mutation_p.D140N|CCNA1_ENST00000440264.1_Missense_Mutation_p.D96N|CCNA1_ENST00000449823.1_Missense_Mutation_p.D96N	NM_001111045.1|NM_003914.3	NP_001104515.1|NP_003905.1	P78396	CCNA1_HUMAN	cyclin A1	140					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		CATCTACATGGATGAACTAGA	0.522000													39	82					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36872607	36872607	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:36872607G>A	ENST00000301807.6	-	21	8582	c.6685C>T	c.(6685-6687)Cat>Tat	p.H2229Y	TRANK1_ENST00000428977.2_Missense_Mutation_p.H2229Y|TRANK1_ENST00000429976.2_Missense_Mutation_p.H2779Y	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2779					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TGTTCTAGATGGATATGCTGC	0.547000													72	87					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286185	48286185	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:48286185G>A	ENST00000320048.1	+	1	773	c.773G>A	c.(772-774)aGg>aAg	p.R258K		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GTCTATATTAGGCCCTGTGTC	0.493000													67	118					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31334094	31334094	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:31334094A>C	ENST00000215862.4	-	14	2349	c.986T>G	c.(985-987)aTc>aGc	p.I329S	MORC2_ENST00000397641.2_Missense_Mutation_p.I391S|MORC2_ENST00000469915.1_Intron	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	391							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						ATACATTTTGATCAGTCGGCT	0.488000													29	55					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24373118	24373118	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:24373118C>T	ENST00000005284.3	+	4	2084	c.882C>T	c.(880-882)tcC>tcT	p.S294S		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	294					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		TCCACAATTCCACACCCAAAG	0.567000													58	92					0	0	1	0	0
LRRC48	83450	broad.mit.edu	37	17	17900816	17900816	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:17900816G>A	ENST00000313838.8	+	10	1246	c.867G>A	c.(865-867)gaG>gaA	p.E289E	LRRC48_ENST00000584166.1_Silent_p.E289E|LRRC48_ENST00000399182.1_Silent_p.E289E|LRRC48_ENST00000399187.1_Silent_p.E289E|LRRC48_ENST00000411504.2_Silent_p.E289E	NM_001130090.1	NP_001123562.1	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48	289						cytoplasm				breast(1)|large_intestine(2)|lung(2)|pancreas(1)|urinary_tract(1)	7	all_neural(463;0.228)					ATATTTTTGAGTATGGCCTGA	0.522000													12	19					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31354891	31354891	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:31354891G>A	ENST00000542188.1	-	8	1344	c.1031C>T	c.(1030-1032)tCc>tTc	p.S344F	TRPM1_ENST00000397795.2_Missense_Mutation_p.S305F|TRPM1_ENST00000256552.6_Missense_Mutation_p.S327F	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	305					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CTCCCTGAGGGACTCATTTAT	0.333000													29	56					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60589625	60589625	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:60589625G>A	ENST00000252996.3	-	2	1498	c.1499C>T	c.(1498-1500)cCc>cTc	p.P500L		NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	500					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GATCTGGACGGGAGGGGCACT	0.667000													20	23					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28545831	28545831	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:28545831G>A	ENST00000401766.2	-	3	974	c.462C>T	c.(460-462)atC>atT	p.I154I	SLC6A4_ENST00000261707.3_Silent_p.I154I			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	154					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	AAATCGGGCAGATTTTCCTCC	0.517000													73	116					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881468	228881468	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:228881468G>A	ENST00000392056.3	-	7	4148	c.4102C>T	c.(4102-4104)Ctc>Ttc	p.L1368F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.L1368F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1368						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGGCAATCGAGAGACTCCTGA	0.502000													47	62					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14748929	14748929	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:14748929C>T	ENST00000253673.5	-	11	1572	c.1472G>A	c.(1471-1473)gGa>gAa	p.G491E	EMR3_ENST00000599900.1_Missense_Mutation_p.G276E|EMR3_ENST00000443157.2_Missense_Mutation_p.G365E|EMR3_ENST00000344373.4_Missense_Mutation_p.G439E	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	491					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						ATCAGCAGTTCCATAAAGGTG	0.493000													64	64					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37975423	37975423	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:37975423A>G	ENST00000330173.1	+	5	1428	c.899A>G	c.(898-900)aAa>aGa	p.K300R	ZNF570_ENST00000586475.1_Missense_Mutation_p.K356R|ZNF570_ENST00000388801.3_Missense_Mutation_p.K97R	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACTGGAGAAAAACCTTACGAA	0.423000													58	81					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832037	61832037	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:61832037C>T	ENST00000280772.1	-	37	8793	c.8602G>A	c.(8602-8604)Gaa>Aaa	p.E2868K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2868					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GAAAGTTTTTCTTTCTGAGAC	0.388000													56	79					0	0	1	0	0
ZNF227	7770	broad.mit.edu	37	19	44739223	44739223	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:44739223C>T	ENST00000313040.7	+	6	845	c.640C>T	c.(640-642)Cat>Tat	p.H214Y	ZNF227_ENST00000391961.2_Missense_Mutation_p.H163Y|ZNF227_ENST00000589005.1_Missense_Mutation_p.H163Y	NM_182490.1	NP_872296.1	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(2)|stomach(1)|urinary_tract(1)	24		Prostate(69;0.0435)				ATCACCATTTCATGAGCATAT	0.358000													35	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179642012	179642012	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:179642012C>T	ENST00000589042.1	-	27	4902	c.4678G>A	c.(4678-4680)Gaa>Aaa	p.E1560K	TTN_ENST00000359218.5_Missense_Mutation_p.E1514K|TTN_ENST00000591111.1_Missense_Mutation_p.E1560K|TTN_ENST00000342992.6_Missense_Mutation_p.E1560K|TTN_ENST00000460472.2_Missense_Mutation_p.E1514K|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000360870.5_Missense_Mutation_p.E1560K|TTN_ENST00000342175.6_Missense_Mutation_p.E1514K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1295	Ig-like 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGTTTTTCTACAAACATC	0.393000													34	52					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138651569	138651569	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:138651569C>T	ENST00000298480.5	+	11	973	c.899C>T	c.(898-900)tCc>tTc	p.S300F	KCNT1_ENST00000490355.2_Missense_Mutation_p.S281F|KCNT1_ENST00000263604.3_Missense_Mutation_p.S281F|KCNT1_ENST00000491806.2_Missense_Mutation_p.S267F|KCNT1_ENST00000488444.2_Missense_Mutation_p.S281F|KCNT1_ENST00000487664.1_Missense_Mutation_p.S255F|KCNT1_ENST00000486577.2_Missense_Mutation_p.S261F|KCNT1_ENST00000371757.2_Missense_Mutation_p.S300F			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	300						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GAGAACCTGTCCCTCCTGACC	0.677000													28	51					0	0	1	0	0
OR51V1	283111	broad.mit.edu	37	11	5221391	5221391	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:5221391G>A	ENST00000321255.1	-	1	539	c.540C>T	c.(538-540)ttC>ttT	p.F180F		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGGATGTGGAAATGACAGT	0.388000													45	70					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42752276	42752276	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:42752276G>A	ENST00000379274.2	+	13	1479	c.1050G>A	c.(1048-1050)acG>acA	p.T350T	DGKH_ENST00000538674.1_Silent_p.T241T|DGKH_ENST00000536612.1_Silent_p.T350T|DGKH_ENST00000337343.4_Silent_p.T486T|DGKH_ENST00000261491.4_Silent_p.T486T|DGKH_ENST00000540693.1_Silent_p.T486T|DGKH_ENST00000498255.2_3'UTR			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	486	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TTCAGATGACGATTTATGAAG	0.378000													56	82					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63885561	63885561	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:63885561G>A	ENST00000246841.3	+	2	2865	c.1822G>A	c.(1822-1824)Gat>Aat	p.D608N	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	580					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						GACCAAGAAGGATAACTCCAT	0.592000													39	52					0	0	1	0	0
ITM2A	9452	broad.mit.edu	37	X	78616940	78616940	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:78616940C>T	ENST00000434584.2	-	4	793	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	ITM2A_ENST00000469541.1_5'UTR|ITM2A_ENST00000373298.2_Missense_Mutation_p.E197K	NM_001171581.1	NP_001165052.1	O43736	ITM2A_HUMAN	integral membrane protein 2A	197	BRICHOS.					integral to membrane	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	18						ACTAGGTCTTCTCGAACCACA	0.383000													26	6					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8009923	8009923	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:8009923T>C	ENST00000318888.4	-	15	1455	c.584A>G	c.(583-585)aAg>aGg	p.K195R	ABLIM2_ENST00000447017.2_Missense_Mutation_p.K494R|ABLIM2_ENST00000341937.5_Splice_Site_p.K460_splice|ABLIM2_ENST00000407564.3_Missense_Mutation_p.K409R|ABLIM2_ENST00000428004.2_Missense_Mutation_p.K420R|ABLIM2_ENST00000361737.5_Splice_Site_p.K419_splice|ABLIM2_ENST00000505872.1_Splice_Site_p.K408_splice|ABLIM2_ENST00000545242.1_Splice_Site_p.K460_splice|ABLIM2_ENST00000514025.1_Missense_Mutation_p.K195R|ABLIM2_ENST00000361581.5_Splice_Site_p.K460_splice|ABLIM2_ENST00000546334.1_Splice_Site_p.K419_splice|ABLIM2_ENST00000296372.8_Missense_Mutation_p.K461R			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	460	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						CCAGCTGCTCTTCTGCTGAAG	0.507000													34	50					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158636178	158636178	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:158636178C>T	ENST00000368148.3	-	16	2328	c.2148G>A	c.(2146-2148)ggG>ggA	p.G716G	SPTA1_ENST00000368147.3_Silent_p.G716G	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	716					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.G716E(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCAGGCCTTTCCCATAATCCT	0.532000													42	31					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50611755	50611755	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:50611755C>T	ENST00000444124.2	-	2	229	c.29G>A	c.(28-30)gGg>gAg	p.G10E	DDC_ENST00000431062.1_Missense_Mutation_p.G10E|DDC_ENST00000426377.1_Missense_Mutation_p.G10E|DDC_ENST00000357936.5_Missense_Mutation_p.G10E|DDC_ENST00000380984.4_Missense_Mutation_p.G10E	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	10					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CATCTCCTTCCCTCTCCTTCG	0.527000													92	180					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219492868	219492868	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:219492868A>G	ENST00000450993.2	+	7	1228	c.889A>G	c.(889-891)Aac>Gac	p.N297D	PLCD4_ENST00000432688.1_Missense_Mutation_p.N297D|PLCD4_ENST00000417849.1_Missense_Mutation_p.N297D	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	297	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TCAACCCCTGAACCACTACTT	0.527000													59	111					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114372637	114372637	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:114372637G>A	ENST00000359785.5	-	17	2203	c.2068C>T	c.(2068-2070)Cgt>Tgt	p.R690C	PTPN22_ENST00000420377.2_Missense_Mutation_p.R690C|PTPN22_ENST00000538253.1_Missense_Mutation_p.R446C|PTPN22_ENST00000528414.1_Missense_Mutation_p.R635C|PTPN22_ENST00000525799.1_Missense_Mutation_p.R563C|PTPN22_ENST00000460620.1_Intron	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	690					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAGAAGAACGATCTTGATGT	0.358000													35	39					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346357	29346357	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:29346357C>T	ENST00000558402.1	+	5	869	c.270C>T	c.(268-270)ctC>ctT	p.L90L	APBA2_ENST00000558330.1_Silent_p.L90L|APBA2_ENST00000411764.1_Silent_p.L90L|APBA2_ENST00000558259.1_Silent_p.L90L|APBA2_ENST00000561069.1_Silent_p.L90L			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	90					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		ACGAGGGCCTCCCTGAGGAGG	0.612000													87	136					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625956	29625956	+	Missense_Mutation	SNP	G	G	A	rs147809085		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:29625956G>A	ENST00000278882.3	+	5	580	c.200G>A	c.(199-201)aGa>aAa	p.R67K	FRG1B_ENST00000358464.4_Missense_Mutation_p.R67K|FRG1B_ENST00000439954.2_Missense_Mutation_p.R72K														p.R67K(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATTGGACCAAGAGAACAATGG	0.338000													5	129					0	0	1	0	0
RPLP0P6	220717	broad.mit.edu	37	2	38709677	38709677	+	RNA	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:38709677A>G	ENST00000417039.1	-	0	696																											CTGTCTGCAGACTGGCTACCC	0.512000													21	47					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372418	126372418	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:126372418G>A	ENST00000394329.3	+	9	10260	c.10247G>A	c.(10246-10248)gGg>gAg	p.G3416E	FAT4_ENST00000335110.5_Missense_Mutation_p.G1714E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3416	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATCAGTGAAGGGGTCCCAATA	0.463000													88	133					0	0	1	0	0
ZNF563	147837	broad.mit.edu	37	19	12430406	12430406	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:12430406G>A	ENST00000293725.5	-	4	638	c.433C>T	c.(433-435)Caa>Taa	p.Q145*	ZNF563_ENST00000595977.1_Nonsense_Mutation_p.Q145*	NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TTCCCACGTTGTTTATGTGTA	0.433000													103	151					0	0	1	0	0
DDX31	64794	broad.mit.edu	37	9	135521432	135521432	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:135521432G>A	ENST00000372159.3	-	13	1696	c.1545C>T	c.(1543-1545)gtC>gtT	p.V515V	DDX31_ENST00000372153.1_Silent_p.V515V|DDX31_ENST00000438527.3_Silent_p.V386V|DDX31_ENST00000310532.2_Silent_p.V515V	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	515	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		TTGAGAAAAAGACAACCATCT	0.478000													20	44					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130340	20130340	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:20130340C>T	ENST00000334554.7	+	10	1328	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F	ZDHHC8_ENST00000320602.7_Missense_Mutation_p.S304F|ZDHHC8_ENST00000405930.3_Missense_Mutation_p.S396F	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	396						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					GACTTTGTGTCCGAGCCGAGC	0.652000													20	28					0	0	1	0	0
ELL2	22936	broad.mit.edu	37	5	95226827	95226827	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:95226827G>A	ENST00000237853.4	-	10	2090	c.1741C>T	c.(1741-1743)Cca>Tca	p.P581S	ELL2_ENST00000431061.2_Missense_Mutation_p.P331S	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	581					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TTTGAGCCTGGAGAAAGGCGC	0.428000													101	160					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2962884	2962884	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:2962884C>T	ENST00000396946.4	-	16	2427	c.2024G>A	c.(2023-2025)aGc>aAc	p.S675N		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	675	PDZ.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGAGGTGAGGCTGTCGCCATT	0.682000			Mis		DLBCL								42	64					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27216652	27216652	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:27216652G>A	ENST00000230582.3	+	3	279	c.264G>A	c.(262-264)tgG>tgA	p.W88*	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	88					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						ACCAACATTGGGTTGGCCAGG	0.522000													54	59					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79094480	79094480	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:79094480G>A	ENST00000326724.4	-	11	3280	c.3256C>T	c.(3256-3258)Cca>Tca	p.P1086S	AATK_ENST00000417379.1_Missense_Mutation_p.P983S	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1086	Pro-rich.					integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			ACCTTGGCTGGGCCTTGGGGC	0.687000													7	7					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27420104	27420104	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:27420104G>A	ENST00000211936.6	-	6	1518	c.1234C>T	c.(1234-1236)Cat>Tat	p.H412Y	ZNF184_ENST00000377419.1_Missense_Mutation_p.H412Y	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						TCACCAGTATGAATCATATGA	0.403000													41	110					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94528179	94528179	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:94528179C>T	ENST00000370225.3	-	13	1977	c.1891G>A	c.(1891-1893)Gga>Aga	p.G631R	ABCA4_ENST00000535735.1_Missense_Mutation_p.G631R	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	631					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AGGTAGATTCCAACTGGAGCC	0.577000													21	29					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30774758	30774758	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:30774758C>T	ENST00000324685.6	+	4	755	c.320C>T	c.(319-321)gCc>gTc	p.A107V	RNF40_ENST00000563683.1_Missense_Mutation_p.A107V|RNF40_ENST00000357890.5_Missense_Mutation_p.A107V|RNF40_ENST00000402121.3_Intron	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	107					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			ACTGTGGAAGCCCTTCTCCGA	0.532000													49	79					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868711	97868711	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:97868711G>A	ENST00000437310.1	+	1	542	c.482G>A	c.(481-483)gGa>gAa	p.G161E		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATCCATGAAGGATTTTTATTC	0.348000													66	199					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6913720	6913720	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:6913720C>T	ENST00000312053.4	+	11	1216	c.1179C>T	c.(1177-1179)ttC>ttT	p.F393F	EMR1_ENST00000381407.5_Silent_p.F252F|EMR1_ENST00000250572.8_Silent_p.F393F|EMR1_ENST00000450315.3_Silent_p.F216F|EMR1_ENST00000381404.4_Silent_p.F341F	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	393	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					GGACTAAATTCACCAAGGAAG	0.458000													53	81					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187235	12187235	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:12187235C>T	ENST00000439326.3	+	4	1475	c.1300C>T	c.(1300-1302)Cct>Tct	p.P434S	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TCTTCCACTTCCTTTCGATAT	0.428000													35	56					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189929294	189929294	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:189929294G>A	ENST00000374866.3	-	25	1979	c.1705C>T	c.(1705-1707)Cca>Tca	p.P569S		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	569					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CGAGCACCTGGAAGCCCAGGT	0.517000													33	61					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5667168	5667168	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:5667168C>T	ENST00000292123.5	+	18	2553	c.2446C>T	c.(2446-2448)Ccc>Tcc	p.P816S	SAFB_ENST00000433404.1_Missense_Mutation_p.P646S|SAFB_ENST00000538656.1_Missense_Mutation_p.P658S|SAFB_ENST00000588852.1_Missense_Mutation_p.P816S|SAFB_ENST00000454510.1_Missense_Mutation_p.P747S|SAFB_ENST00000592224.1_Missense_Mutation_p.P815S	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	816	Arg-rich.|Gly-rich.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GCTGCCTCCTCCCCCCAGGTT	0.697000													18	30					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539350	55539350	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:55539350G>A	ENST00000220676.1	+	4	3056	c.2908G>A	c.(2908-2910)Gaa>Aaa	p.E970K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	970					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTTTGTTATGGAAAGTAATAA	0.328000													52	67					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	17978463	17978463	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:17978463C>T	ENST00000262608.8	+	3	304	c.304C>T	c.(304-306)Cgt>Tgt	p.R102C	CECR2_ENST00000342247.5_Missense_Mutation_p.R101C|CECR2_ENST00000497534.1_3'UTR|CECR2_ENST00000400573.4_Missense_Mutation_p.R121C|CECR2_ENST00000400585.2_5'UTR	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	143					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGACAGTCTCCGTGTGGAGCC	0.488000													28	32					0	0	1	0	0
AP5B1	91056	broad.mit.edu	37	11	65547165	65547165	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:65547165G>A	ENST00000532090.2	-	2	1009	c.799C>T	c.(799-801)Ctg>Ttg	p.L267L		NM_138368.4	NP_612377.4	Q2VPB7	YK046_HUMAN	adaptor-related protein complex 5, beta 1 subunit	210	Leu-rich.						protein binding			lung(1)	1						GCAGCCCGCAGCTCCCGCGCC	0.692000													44	65					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113170211	113170211	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:113170211C>T	ENST00000401783.2	-	38	8005	c.7669G>A	c.(7669-7671)Gat>Aat	p.D2557N	SVEP1_ENST00000374469.1_Missense_Mutation_p.D2534N|SVEP1_ENST00000297826.5_Missense_Mutation_p.D483N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2557	Sushi 20.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TGTGGGGAATCACAGTGGATG	0.498000													26	47					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20228766	20228766	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:20228766C>T	ENST00000418063.2	+	4	515	c.403C>T	c.(403-405)Caa>Taa	p.Q135*	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	135						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						TGGACTTAACCAATGTTTGAC	0.318000													7	25					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32828135	32828135	+	Silent	SNP	C	C	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:32828135C>A	ENST00000421745.2	+	71	14189	c.14055C>A	c.(14053-14055)acC>acA	p.T4685T		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4685	Ubiquitin-conjugating.				anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ATCCTCAGACCTCAAGCTTTT	0.318000													17	34					1.67942e-08	1.69064e-08	1	1	0
GLI3	2737	broad.mit.edu	37	7	42085042	42085042	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:42085042G>A	ENST00000395925.3	-	6	851	c.767C>T	c.(766-768)cCc>cTc	p.P256L	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	256					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GGCAGCTGAGGGAATAATGTC	0.557000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				64	119					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189933514	189933514	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:189933514G>A	ENST00000374866.3	-	19	1529	c.1255C>T	c.(1255-1257)Cct>Tct	p.P419S		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	419					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AAACTTACAGGAAGACCTGGA	0.468000													13	38					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186459315	186459315	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:186459315C>T	ENST00000265023.4	+	10	1342	c.1130C>T	c.(1129-1131)tCa>tTa	p.S377L	KNG1_ENST00000287611.2_Missense_Mutation_p.S377L|KNG1_ENST00000447445.1_Missense_Mutation_p.S341L|RP11-573D15.8_ENST00000599314.1_RNA|RP11-573D15.8_ENST00000354642.2_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	377	Cystatin 3.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GTTTAGATCTCACTGATGAAA	0.358000													35	54					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11725355	11725355	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:11725355C>T	ENST00000381486.2	+	8	1270	c.970C>T	c.(970-972)Cca>Tca	p.P324S	GREB1_ENST00000381483.2_Missense_Mutation_p.P324S|GREB1_ENST00000263834.5_Missense_Mutation_p.P324S|GREB1_ENST00000234142.5_Missense_Mutation_p.P324S	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	324						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCCATCAGCTCCAGATGGTGG	0.517000													12	32					0	0	1	0	0
ASIC5	51802	broad.mit.edu	37	4	156753060	156753060	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:156753060G>A	ENST00000537611.2	-	9	1289	c.1243C>T	c.(1243-1245)Ctt>Ttt	p.L415F		NM_017419.2	NP_059115.1	Q9NY37	ACCN5_HUMAN	acid-sensing (proton-gated) ion channel family member 5	415						integral to membrane|plasma membrane											ATTTTTACAAGATTCTCCCTA	0.308000													55	105					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96205200	96205200	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:96205200G>A	ENST00000299339.2	+	1	222	c.193G>A	c.(193-195)Gac>Aac	p.D65N	CLDN10_ENST00000376873.3_Intron	NM_006984.4	NP_008915.1	P78369	CLD10_HUMAN	claudin 10	65					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			CAACTGCAAGGACTTCCCCTC	0.672000													25	52					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176998830	176998830	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:176998830C>T	ENST00000367654.2	-	5	1073	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	ASTN1_ENST00000361833.2_Missense_Mutation_p.E354K|ASTN1_ENST00000367657.3_Missense_Mutation_p.E354K|ASTN1_ENST00000424564.2_Missense_Mutation_p.E354K|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	354					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GGGTCGTTTTCTGCCTCTGTG	0.502000													26	37					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54543926	54543926	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:54543926C>T	ENST00000566473.2	+	14	1776	c.1776C>T	c.(1774-1776)acC>acT	p.T592T	ANKFN1_ENST00000318698.2_Silent_p.T592T			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	592										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						TACTGATAACCATCCAGGTAT	0.378000													10	15					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77672723	77672723	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:77672723C>T	ENST00000407578.2	-	56	8832	c.8566G>A	c.(8566-8568)Gct>Act	p.A2856T	MYCBP2_ENST00000357337.6_Missense_Mutation_p.A2818T|MYCBP2_ENST00000482517.1_5'UTR|MYCBP2_ENST00000360084.5_Missense_Mutation_p.A341T|MYCBP2_ENST00000544440.2_Missense_Mutation_p.A2818T	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2818					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTAACAGGAGCAGTACTTTTT	0.473000													41	69					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2784559	2784559	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:2784559C>T	ENST00000320876.6	+	45	5997	c.5659C>T	c.(5659-5661)Cgg>Tgg	p.R1887W	SMCHD1_ENST00000261598.8_Missense_Mutation_p.R1887W|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1887					chromosome organization		ATP binding	p.R1887W(2)|p.R1335W(1)		NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						GGATAAACTTCGGGGAATGGT	0.398000													9	21					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112694273	112694273	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:112694273G>T	ENST00000550722.1	-	21	3135	c.2740C>A	c.(2740-2742)Cct>Act	p.P914T	HECTD4_ENST00000430131.2_Missense_Mutation_p.P628T|HECTD4_ENST00000377560.5_Missense_Mutation_p.P878T	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CATGGGGCAGGAATCTTTAAA	0.443000													20	29					1.00905e-13	1.01969e-13	1	1	0
ATXN7	6314	broad.mit.edu	37	3	63981493	63981493	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:63981493C>T	ENST00000398590.3	+	12	2548	c.1995C>T	c.(1993-1995)tcC>tcT	p.S665S	ATXN7_ENST00000487717.1_Silent_p.S665S|ATXN7_ENST00000538065.1_Silent_p.S665S|ATXN7_ENST00000295900.6_Silent_p.S665S|ATXN7_ENST00000484332.1_Silent_p.S520S	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	665	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		TTCCTTCCTCCCCCATGTCCA	0.512000													44	84					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42416644	42416644	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:42416644G>A	ENST00000381668.5	-	36	3628	c.3397_splice	c.e36+1	p.H1133_splice	ATP8A1_ENST00000264449.10_Splice_Site_p.H1118_splice	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	1133					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	AAATACTCACGGAGCAGATTT	0.393000													38	66					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7111499	7111499	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:7111499G>A	ENST00000399510.2	-	4	1071	c.219C>T	c.(217-219)ccC>ccT	p.P73P	DLG4_ENST00000399506.2_Silent_p.P30P|DLG4_ENST00000485100.1_Silent_p.P30P|DLG4_ENST00000302955.6_Silent_p.P30P	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	30	PDZ 1.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						TTACCTGGTTGGGGAGGTGGG	0.682000													54	72					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510522	101510522	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:101510522C>T	ENST00000392979.3	+	24	2772	c.2411C>T	c.(2410-2412)tCt>tTt	p.S804F	ANO4_ENST00000550015.1_Missense_Mutation_p.S359F|ANO4_ENST00000392977.3_Missense_Mutation_p.S839F|ANO4_ENST00000299222.9_Missense_Mutation_p.S359F	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	839						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GAGAACCGATCTGAGCCTGAA	0.512000										HNSCC(74;0.22)			76	121					0	0	1	0	0
LRRC4	64101	broad.mit.edu	37	7	127668930	127668930	+	Silent	SNP	G	G	A	rs139849197		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:127668930G>A	ENST00000249363.3	-	2	2021	c.1764C>T	c.(1762-1764)tcC>tcT	p.S588S	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	588						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		CTGATACACCGGACGGAgctg	0.547000													18	26					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007949	6007949	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:6007949G>A	ENST00000332249.4	-	1	266	c.212C>T	c.(211-213)cCa>cTa	p.P71L		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGCAAGGATGGGTCCATCCA	0.532000													25	38					0	0	1	0	0
FOSL2	2355	broad.mit.edu	37	2	28635187	28635187	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:28635187C>T	ENST00000264716.4	+	4	1716	c.853C>T	c.(853-855)Cct>Tct	p.P285S	FOSL2_ENST00000379619.1_Missense_Mutation_p.P277S|FOSL2_ENST00000545753.1_Missense_Mutation_p.P246S	NM_005253.3	NP_005244.1	P15408	FOSL2_HUMAN	FOS-like antigen 2	285					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTTCACCTATCCTAGCGTCCT	0.617000													27	54					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51399381	51399381	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:51399381G>A	ENST00000266037.9	+	48	5121	c.5098G>A	c.(5098-5100)Gac>Aac	p.D1700N		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1700						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GATGCTGGGTGACGGCTCCAT	0.572000													12	15					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538522	55538522	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:55538522G>A	ENST00000220676.1	+	4	2228	c.2080G>A	c.(2080-2082)Gga>Aga	p.G694R		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	694					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGCAACCAAAGGAATTCTTAA	0.353000													21	42					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28728530	28728530	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:28728530C>T	ENST00000257197.3	-	6	964	c.703G>A	c.(703-705)Gat>Aat	p.D235N	DSC1_ENST00000257198.5_Missense_Mutation_p.D235N|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	235	Cadherin 1.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTATCATTATCATCTTCAATT	0.383000													50	85					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118530812	118530812	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:118530812G>A	ENST00000336338.5	-	39	5602	c.5537C>T	c.(5536-5538)aCt>aTt	p.T1846I		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1846						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GAATAAATCAGTTAGGTGAGC	0.373000													14	38					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152384066	152384066	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:152384066C>T	ENST00000397345.3	-	147	21971	c.21769G>A	c.(21769-21771)Gcc>Acc	p.A7257T	NEB_ENST00000172853.10_Missense_Mutation_p.A5556T|NEB_ENST00000604864.1_Missense_Mutation_p.A7257T|NEB_ENST00000603639.1_Missense_Mutation_p.A7257T|NEB_ENST00000427231.2_Missense_Mutation_p.A7257T|NEB_ENST00000409198.1_Missense_Mutation_p.A5556T	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5556					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCCAGTGGGCTTTGTTGGCT	0.473000													7	18					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043467	117043467	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:117043467C>T	ENST00000371876.1	-	4	3431	c.1010G>A	c.(1009-1011)gGa>gAa	p.G337E	KLHL13_ENST00000545703.1_Missense_Mutation_p.G346E|KLHL13_ENST00000469946.1_Missense_Mutation_p.G337E|KLHL13_ENST00000541812.1_Missense_Mutation_p.G372E|KLHL13_ENST00000371882.1_Missense_Mutation_p.G337E|KLHL13_ENST00000540167.1_Missense_Mutation_p.G372E|KLHL13_ENST00000371878.1_Missense_Mutation_p.G337E|KLHL13_ENST00000262820.3_Missense_Mutation_p.G388E|KLHL13_ENST00000539496.1_Missense_Mutation_p.G391E			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	388					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GAGAAAATTTCCAATGACGGC	0.443000													62	13					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46245377	46245377	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:46245377C>T	ENST00000296140.3	-	2	553	c.428G>A	c.(427-429)cGg>cAg	p.R143Q	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	143					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GGTCCGTGCCCGCAAGGCAAA	0.517000													32	57					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917338	65917338	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:65917338C>T	ENST00000261892.6	+	2	1207	c.920C>T	c.(919-921)cCc>cTc	p.P307L	SLC24A1_ENST00000399033.4_Missense_Mutation_p.P307L|SLC24A1_ENST00000537259.1_Missense_Mutation_p.P307L|SLC24A1_ENST00000544319.2_Missense_Mutation_p.P307L|SLC24A1_ENST00000339868.6_Missense_Mutation_p.P307L|SLC24A1_ENST00000546330.1_Missense_Mutation_p.P307L	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	307					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CCGAAGACTCCCCAGGGAACA	0.547000													56	98					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50463870	50463870	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:50463870C>T	ENST00000447370.2	-	2	489	c.399G>A	c.(397-399)gtG>gtA	p.V133V	SIGLEC11_ENST00000426971.2_Silent_p.V133V	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	133	Ig-like V-type.				cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		TTCCTCTCTCCACCCGAAAGA	0.557000													7	151					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222301148	222301148	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:222301148C>T	ENST00000281821.2	-	13	2358	c.2317G>A	c.(2317-2319)Gat>Aat	p.D773N	EPHA4_ENST00000409854.1_Missense_Mutation_p.D773N|EPHA4_ENST00000409938.1_Missense_Mutation_p.D773N|EPHA4_ENST00000392071.4_Missense_Mutation_p.D722N	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	773	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TCCGGATCATCCTCAAGCACT	0.493000													30	49					0	0	1	0	0
SCYL2	55681	broad.mit.edu	37	12	100717410	100717410	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:100717410C>T	ENST00000360820.2	+	11	1940	c.1503C>T	c.(1501-1503)tcC>tcT	p.S501S		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	501					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						AAACATCTTCCCTTGCGGTAA	0.303000													33	38					0	0	1	0	0
PHF20L1	51105	broad.mit.edu	37	8	133816978	133816978	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:133816978G>C	ENST00000395386.2	+	8	1139	c.840G>C	c.(838-840)aaG>aaC	p.K280N	PHF20L1_ENST00000337920.4_Missense_Mutation_p.K254N|PHF20L1_ENST00000395374.1_Missense_Mutation_p.K119N|PHF20L1_ENST00000395376.1_Missense_Mutation_p.K285N|PHF20L1_ENST00000395382.3_Missense_Mutation_p.K150N|PHF20L1_ENST00000395383.1_Missense_Mutation_p.K284N|PHF20L1_ENST00000395390.2_Missense_Mutation_p.K255N|PHF20L1_ENST00000315808.10_Missense_Mutation_p.K280N|PHF20L1_ENST00000220847.7_5'UTR|PHF20L1_ENST00000395379.1_Missense_Mutation_p.K280N	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	280							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GACTTAACAAGATTACTGGTA	0.333000													61	147					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51140561	51140561	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:51140561G>A	ENST00000338916.4	-	1	741	c.108C>T	c.(106-108)ttC>ttT	p.F36F	SYT3_ENST00000593901.1_Silent_p.F36F|SYT3_ENST00000544769.1_Silent_p.F36F|SYT3_ENST00000600079.1_Silent_p.F36F	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	36						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		TTCGGTCATTGAACTCCTGGC	0.632000													40	63					0	0	1	0	0
TMEM209	84928	broad.mit.edu	37	7	129832639	129832639	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:129832639G>A	ENST00000397622.2	-	6	720	c.598C>T	c.(598-600)Cct>Tct	p.P200S	TMEM209_ENST00000473456.1_Missense_Mutation_p.P200S|TMEM209_ENST00000336804.8_Missense_Mutation_p.P199S|RP11-775D22.3_ENST00000483283.1_RNA|TMEM209_ENST00000462753.1_Missense_Mutation_p.P199S	NM_032842.3	NP_116231.2	Q96SK2	TM209_HUMAN	transmembrane protein 209	200	Ser-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	12	Melanoma(18;0.0435)					TACGGAGAAGGAGGAGAGGGG	0.398000													18	43					0	0	1	0	0
SCARNA2	677766	broad.mit.edu	37	1	109643057	109643057	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:109643057C>T	ENST00000458748.1	+	0	243					NR_003023.1																						AAGCTCTCCTCCTGCGAAGCC	0.706000													15	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179499914	179499914	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:179499914C>T	ENST00000589042.1	-	228	42226	c.42002G>A	c.(42001-42003)gGa>gAa	p.G14001E	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G5061E|TTN_ENST00000591111.1_Missense_Mutation_p.G12360E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G11433E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G4936E|TTN_ENST00000342175.6_Missense_Mutation_p.G5128E|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12360	Ig-like 95.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGAAGTTCTCCTTTCAGTTT	0.368000													38	82					0	0	1	0	0
CEP120	153241	broad.mit.edu	37	5	122727023	122727023	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:122727023G>A	ENST00000306467.5	-	7	1123	c.819C>T	c.(817-819)ctC>ctT	p.L273L	CEP120_ENST00000328236.5_Silent_p.L273L|CEP120_ENST00000395431.2_Silent_p.L273L|CEP120_ENST00000306481.6_Silent_p.L247L			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	273						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						CTCCACAGCAGAGGTGAATCT	0.363000													54	96					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10299732	10299732	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:10299732C>T	ENST00000403437.2	-	33	4662	c.4568G>A	c.(4567-4569)gGa>gAa	p.G1523E	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1523					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						AATTTGCTTTCCTCCCTCTGC	0.428000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				13	24					0	0	1	0	0
HOXB2	3212	broad.mit.edu	37	17	46620947	46620947	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:46620947C>A	ENST00000330070.4	-	2	1721	c.554G>T	c.(553-555)aGg>aTg	p.R185M	HOXB-AS1_ENST00000504972.3_RNA	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	185					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						TTTGACCTGCCTTTCGGTGAG	0.622000													67	84					9.12251e-31	9.25422e-31	1	1	0
MAGEA12	4111	broad.mit.edu	37	X	151900533	151900533	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:151900533C>T	ENST00000393900.3	-	3	621	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	MAGEA12_ENST00000357916.4_Missense_Mutation_p.E90K|MAGEA12_ENST00000393869.3_Missense_Mutation_p.E90K|CSAG4_ENST00000361201.4_RNA	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	90										breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTGTTCTTCGTTGCTGGAG	0.542000													74	27					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028360	21028360	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:21028360C>T	ENST00000381545.3	+	9	1138	c.919C>T	c.(919-921)Caa>Taa	p.Q307*	SLCO1B3_ENST00000261196.2_Nonsense_Mutation_p.Q307*|LST3_ENST00000540229.1_Nonsense_Mutation_p.Q307*|SLCO1B3_ENST00000553473.1_Nonsense_Mutation_p.Q307*|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	307					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity	p.Q307E(1)		breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TGATAGAAATCAAACAGCTAA	0.303000													32	48					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47809679	47809679	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:47809679T>C	ENST00000285106.6	-	13	2341	c.1627A>G	c.(1627-1629)Aag>Gag	p.K543E	CXXC1_ENST00000412036.2_Missense_Mutation_p.K547E|CXXC1_ENST00000589940.1_Silent_p.V530V	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	543					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						TGGAGCCGCTTACAGTATGTT	0.577000													46	94					0	0	1	0	0
SLC39A4	55630	broad.mit.edu	37	8	145638191	145638191	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:145638191G>A	ENST00000276833.5	-	10	1995	c.1692C>T	c.(1690-1692)atC>atT	p.I564I	SLC39A4_ENST00000301305.3_Silent_p.I589I|SLC39A4_ENST00000531013.1_5'UTR	NM_017767.2	NP_060237.2	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter), member 4	589						cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	14	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			CCACTGCCAGGATCCAGGCCT	0.667000													18	61					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52639699	52639699	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:52639699C>T	ENST00000355568.4	-	22	2110	c.1971G>A	c.(1969-1971)tgG>tgA	p.W657*		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	657							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTCCTCCATCCCACTGCCTCC	0.537000													25	45					0	0	1	0	0
CTAGE9	643854	broad.mit.edu	37	6	132031200	132031200	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:132031200G>A	ENST00000314099.8	-	1	1006	c.958C>T	c.(958-960)Cat>Tat	p.H320Y	ENPP3_ENST00000414305.1_Intron|ENPP3_ENST00000358229.5_Intron|ENPP3_ENST00000357639.3_Intron	NM_001145659.1|NM_001278507.1	NP_001139131.1|NP_001265436.1	A4FU28	CTGE9_HUMAN	CTAGE family, member 9	320						integral to membrane				endometrium(1)|lung(1)	2						TTAGCAGCATGAATCAGTTTC	0.358000													18	19					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130765052	130765052	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:130765052C>T	ENST00000276708.4	-	7	1617	c.736G>A	c.(736-738)Gaa>Aaa	p.E246K		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	246						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						cctaccatttcggaaatttcg	0.473000													56	56					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60744889	60744889	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:60744889C>T	ENST00000303375.5	+	6	1514	c.1112C>T	c.(1111-1113)cCt>cTt	p.P371L		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	371					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GAGCCCACCCCTCCAGGTGAG	0.687000													31	46					0	0	1	0	0
OR10A3	26496	broad.mit.edu	37	11	7960713	7960713	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:7960713C>T	ENST00000360759.3	-	1	428	c.355G>A	c.(355-357)Gct>Act	p.A119T		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGGTCATAAGCCATCGCTCCC	0.403000													58	80					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102249834	102249834	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:102249834G>A	ENST00000370345.3	-	21	2993	c.2896C>T	c.(2896-2898)Ctt>Ttt	p.L966F		NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	966	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TCCCCTGGAAGGTATGGCACA	0.602000													32	80					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862259	5862259	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:5862259G>A	ENST00000329322.5	-	1	868	c.869C>T	c.(868-870)cCt>cTt	p.P290L	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Missense_Mutation_p.P294L	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATAGATTACAGGATTGAGGGT	0.413000													32	71					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44449631	44449631	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:44449631G>A	ENST00000360029.3	-	1	1193	c.910C>T	c.(910-912)Cag>Tag	p.Q304*		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	304						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TCGCGGTACTGGTTGACGAAG	0.612000										HNSCC(17;0.042)			19	34					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21792458	21792458	+	Translation_Start_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:21792458C>T	ENST00000281523.2	-	0	469				ZNF385D_ENST00000494118.1_Intron	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D							nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TCAGCTCTCACCCAAGGCTGG	0.532000													25	31					0	0	1	0	0
NXPE1	120400	broad.mit.edu	37	11	114392862	114392862	+	Missense_Mutation	SNP	C	C	T	rs17852630		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:114392862C>T	ENST00000536271.1	-	4	1863	c.620G>A	c.(619-621)gGa>gAa	p.G207E	NXPE1_ENST00000251921.2_Missense_Mutation_p.G349E|NXPE1_ENST00000424269.1_Missense_Mutation_p.G491E					neurexophilin and PC-esterase domain family, member 1																		ATGGAAGTCTCCAAACCTCTC	0.413000													59	79					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856741	53856741	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:53856741C>T	ENST00000458035.1	+	4	2930	c.2813C>T	c.(2812-2814)aCt>aTt	p.T938I	ZNF845_ENST00000595091.1_Missense_Mutation_p.T938I	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	938					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						ACAATTCATACTGGAGAGAAA	0.358000													10	43					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588671	247588671	+	Silent	SNP	C	C	T	rs34698071	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:247588671C>T	ENST00000366497.2	+	4	2706	c.1926C>T	c.(1924-1926)ttC>ttT	p.F642F	NLRP3_ENST00000366496.2_Silent_p.F642F|NLRP3_ENST00000391827.2_Silent_p.F642F|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000391828.3_Silent_p.F642F|NLRP3_ENST00000336119.3_Silent_p.F642F|NLRP3_ENST00000348069.2_Silent_p.F642F	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	642					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGGAGGACTTCGTGCAAAGGG	0.468000													29	69					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30408182	30408182	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:30408182G>A	ENST00000375994.2	+	2	579	c.306G>A	c.(304-306)gcG>gcA	p.A102A	MYLK2_ENST00000375985.4_Silent_p.A102A			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	102					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGCAGACTGCGACACCTGAGA	0.692000													19	37					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867415	6867415	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:6867415C>T	ENST00000299454.4	+	1	533	c.502C>T	c.(502-504)Cca>Tca	p.P168S	OR10A5_ENST00000379831.2_Missense_Mutation_p.P172S			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTTCAGTTTTCCATTCTGTGG	0.527000													68	122					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261979	39261979	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:39261979C>T	ENST00000391415.1	+	1	396	c.339C>T	c.(337-339)acC>acT	p.T113T		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	113	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						GTGAGACGACCTGCTGCCACC	0.662000													16	38					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79094479	79094479	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:79094479G>A	ENST00000326724.4	-	11	3281	c.3257C>T	c.(3256-3258)cCa>cTa	p.P1086L	AATK_ENST00000417379.1_Missense_Mutation_p.P983L	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1086	Pro-rich.					integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CACCTTGGCTGGGCCTTGGGG	0.687000													7	7					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1437330	1437330	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:1437330G>A	ENST00000345913.4	+	4	391	c.300G>A	c.(298-300)gcG>gcA	p.A100A	TPO_ENST00000329066.4_Silent_p.A100A|TPO_ENST00000337415.3_Silent_p.A100A|TPO_ENST00000382201.3_Silent_p.A100A|TPO_ENST00000346956.3_Silent_p.A100A|TPO_ENST00000349624.3_Silent_p.A100A|TPO_ENST00000497517.2_Intron|TPO_ENST00000382269.3_Silent_p.A100A|TPO_ENST00000539820.1_Silent_p.A100A|TPO_ENST00000382198.1_Silent_p.A100A	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	100					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAATACAAGCGATGAAAAGAA	0.493000													34	57					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97251297	97251297	+	Missense_Mutation	SNP	C	C	T	rs139774071	by1000genomes	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:97251297C>T	ENST00000389672.5	+	11	2334	c.2296C>T	c.(2296-2298)Cgg>Tgg	p.R766W	EPHA6_ENST00000502694.1_Missense_Mutation_p.R158W|EPHA6_ENST00000442602.2_Missense_Mutation_p.R132W|EPHA6_ENST00000514100.1_Missense_Mutation_p.R158W	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	671	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.R672R(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CCACATGGATCGGCAAAGAAG	0.433000													32	60					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306679	54306679	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:54306679C>T	ENST00000545554.1	+	1	1579	c.1579C>T	c.(1579-1581)Cat>Tat	p.H527Y	UNC13C_ENST00000260323.11_Missense_Mutation_p.H527Y|UNC13C_ENST00000537900.1_Missense_Mutation_p.H527Y			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	527					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AACCACAACCCATTATGCAGA	0.363000													36	44					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	39967563	39967563	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:39967563C>T	ENST00000308666.3	-	9	2093	c.1958G>A	c.(1957-1959)gGg>gAg	p.G653E		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	653	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						AATTCCAGCCCCTTTTGCAGC	0.378000													31	57					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31334093	31334093	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:31334093G>C	ENST00000215862.4	-	14	2350	c.987C>G	c.(985-987)atC>atG	p.I329M	MORC2_ENST00000397641.2_Missense_Mutation_p.I391M|MORC2_ENST00000469915.1_Intron	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	391							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						CATACATTTTGATCAGTCGGC	0.488000													30	56					0	0	1	0	0
GSTCD	79807	broad.mit.edu	37	4	106640681	106640681	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:106640681C>T	ENST00000515279.1	+	3	1111	c.891C>T	c.(889-891)ttC>ttT	p.F297F	GSTCD_ENST00000394728.3_Silent_p.F297F|GSTCD_ENST00000394730.3_Silent_p.F210F|GSTCD_ENST00000515255.1_Intron|GSTCD_ENST00000360505.5_Silent_p.F297F|GSTCD_ENST00000507281.1_Silent_p.F210F			Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain containing	297	GST C-terminal.					cytoplasm	rRNA methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	14		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		TCCATCATTTCTTGGTAAGGT	0.403000													29	58					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115166206	115166206	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:115166206G>A	ENST00000393274.1	-	5	1490	c.865C>T	c.(865-867)Cgt>Tgt	p.R289C	DENND2C_ENST00000393277.1_Missense_Mutation_p.R289C|DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Missense_Mutation_p.R289C	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	289										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGTTCTTCACGAATCGTCTGT	0.343000													32	79					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242401950	242401950	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:242401950G>A	ENST00000264042.3	+	15	1770	c.1600G>A	c.(1600-1602)Gac>Aac	p.D534N	FARP2_ENST00000545004.1_Missense_Mutation_p.D534N|FARP2_ENST00000373287.4_Missense_Mutation_p.D534N	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	534					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CGTGCCTGCAGACGAGGCCTA	0.488000													72	56					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18234941	18234941	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:18234941G>A	ENST00000262811.5	+	8	739	c.739G>A	c.(739-741)Gag>Aag	p.E247K		NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	247							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						GGAGAAGCTGGAGCGGCTTCT	0.602000													8	16					0	0	1	0	0
LRRC20	55222	broad.mit.edu	37	10	72083658	72083658	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:72083658C>T	ENST00000355790.4	-	4	838	c.361G>A	c.(361-363)Gcg>Acg	p.A121T	LRRC20_ENST00000373224.1_Missense_Mutation_p.A121T|LRRC20_ENST00000358141.2_Missense_Mutation_p.A71T|LRRC20_ENST00000395011.1_Missense_Mutation_p.A71T|LRRC20_ENST00000395010.1_Intron	NM_001278212.1|NM_001278214.1|NM_207119.1	NP_001265141.1|NP_001265143.1|NP_997002.1	Q8TCA0	LRC20_HUMAN	leucine rich repeat containing 20	121										endometrium(2)|large_intestine(4)|lung(2)|urinary_tract(1)	9						GTCTCCAGCGCCGGCAGGGCG	0.662000													33	74					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38556912	38556912	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:38556912G>A	ENST00000423485.1	-	22	2826	c.2668C>T	c.(2668-2670)Cca>Tca	p.P890S		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	890					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTGTAACTTGGAAGCTAAATT	0.303000													14	28					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155451079	155451079	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:155451079G>A	ENST00000461783.3	+	6	1995	c.722G>A	c.(721-723)aGc>aAc	p.S241N	TIAM2_ENST00000456144.1_Missense_Mutation_p.S241N|TIAM2_ENST00000318981.5_Missense_Mutation_p.S241N|TIAM2_ENST00000529824.2_Missense_Mutation_p.S241N|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000360366.4_Missense_Mutation_p.S241N			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	241					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGCAAAGGCAGCTCCCTGAGT	0.667000													44	35					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110505956	110505956	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:110505956C>T	ENST00000378402.5	+	63	10407	c.10303C>T	c.(10303-10305)Cgc>Tgc	p.R3435C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3435					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGCAGGATACCGCATTGATGG	0.333000										HNSCC(38;0.096)			30	33					0	0	1	0	0
LCE1A	353131	broad.mit.edu	37	1	152799963	152799963	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:152799963G>A	ENST00000335123.2	+	1	15	c.15G>A	c.(13-15)caG>caA	p.Q5Q		NM_178348.2	NP_848125.1	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	5	Cys-rich.				keratinization					endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	8	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCTGCCAGCAGAGCCAGCAGC	0.607000													118	78					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41798299	41798299	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:41798299C>T	ENST00000392006.3	+	8	1322	c.1149C>T	c.(1147-1149)ttC>ttT	p.F383F	HNRNPUL1_ENST00000378215.4_Silent_p.F269F|HNRNPUL1_ENST00000593587.1_Silent_p.F283F|HNRNPUL1_ENST00000595018.1_Silent_p.F283F|HNRNPUL1_ENST00000263367.3_Silent_p.F294F|HNRNPUL1_ENST00000602130.1_Silent_p.F383F|HNRNPUL1_ENST00000352456.3_Silent_p.F283F	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	383	B30.2/SPRY.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						AGTTCAACTTCGGACAGAGAG	0.557000													68	120					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153578163	153578163	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:153578163G>A	ENST00000422373.1	-	45	7630	c.7382C>T	c.(7381-7383)cCc>cTc	p.P2461L	FLNA_ENST00000344736.4_Missense_Mutation_p.P2429L|FLNA_ENST00000498491.1_5'UTR|FLNA_ENST00000360319.4_Missense_Mutation_p.P2461L|FLNA_ENST00000369856.3_Missense_Mutation_p.P602L|FLNA_ENST00000369850.3_Missense_Mutation_p.P2469L	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2469					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACCTTGGAGGGGCCGTCAAT	0.617000											OREG0003592	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	26	10					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775547	77775547	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:77775547G>A	ENST00000521891.2	+	11	10045	c.9597G>A	c.(9595-9597)gtG>gtA	p.V3199V	ZFHX4_ENST00000455469.2_Silent_p.V3154V|ZFHX4_ENST00000518282.1_Silent_p.V3173V|ZFHX4_ENST00000050961.6_Silent_p.V3150V	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3150						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAACAAGGTGAAAAAAATCA	0.448000										HNSCC(33;0.089)			30	48					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108469040	108469040	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:108469040A>C	ENST00000263054.6	-	7	1091	c.1084T>G	c.(1084-1086)Ttt>Gtt	p.F362V	SORCS1_ENST00000344440.6_Missense_Mutation_p.F362V	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	362						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TAGCCTGGAAAAGGCTGATTC	0.398000													31	61					0	0	1	0	0
OR51B2	79345	broad.mit.edu	37	11	5345472	5345472	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:5345472T>C	ENST00000328813.2	-	1	110	c.56A>G	c.(55-57)gAg>gGg	p.E19G	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGAGCTGCCTCCAGCCCTGG	0.488000											OREG0003719	type=REGULATORY REGION|Gene=OR51B2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	28	41					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49934757	49934757	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:49934757G>A	ENST00000296474.3	-	7	2166	c.2139C>T	c.(2137-2139)acC>acT	p.T713T	MST1R_ENST00000344206.4_Silent_p.T713T	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	713	IPT/TIG 2.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CAGCCCGGCTGGTGCCTACAG	0.612000													46	74					0	0	1	0	0
FCN1	2219	broad.mit.edu	37	9	137803047	137803047	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:137803047G>A	ENST00000371806.3	-	8	756	c.665C>T	c.(664-666)tCa>tTa	p.S222L		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	222	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CACCTTGAATGATTTGTACTT	0.542000													133	219					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21462822	21462822	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:21462822G>A	ENST00000281523.2	-	8	1590	c.1072C>T	c.(1072-1074)Cga>Tga	p.R358*		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	358						nucleus	nucleic acid binding|zinc ion binding	p.R358*(1)		NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						GGAGCAGTTCGAAGACTGAAG	0.582000													20	26					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217142480	217142480	+	Silent	SNP	G	G	A	rs139354980		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:217142480G>A	ENST00000273067.4	-	3	2546	c.780C>T	c.(778-780)ttC>ttT	p.F260F		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	260						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		CCGAGGGGCTGAAAGTTGACC	0.557000													77	102					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111797602	111797602	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:111797602C>T	ENST00000452346.2	+	17	2241	c.2238C>T	c.(2236-2238)tcC>tcT	p.S746S	TMPRSS7_ENST00000419127.1_Silent_p.S620S			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	746	Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						ATAAAGGCTCCCTCGTTCTGC	0.433000													39	68					0	0	1	0	0
RAB3D	9545	broad.mit.edu	37	19	11447877	11447877	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:11447877G>A	ENST00000222120.3	-	2	459	c.199C>T	c.(199-201)Cat>Tat	p.H67Y	RAB3D_ENST00000589655.1_Missense_Mutation_p.H67Y	NM_004283.3	NP_004274.1	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	67					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|ovary(2)	14						CTCTTGTCATGGCGGTAGACG	0.562000													146	245					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80256719	80256719	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:80256719C>T	ENST00000265080.4	+	1	229	c.162C>T	c.(160-162)ttC>ttT	p.F54F	CTC-459I6.1_ENST00000505694.1_RNA	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	54	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TCTTCTACTTCGAGGGCGAGC	0.687000													24	42					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72127916	72127916	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:72127916C>T	ENST00000340726.3	-	15	2047	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	EYA1_ENST00000419131.1_Missense_Mutation_p.E435K|EYA1_ENST00000303824.7_Missense_Mutation_p.E464K|EYA1_ENST00000388740.3_Missense_Mutation_p.E437K|EYA1_ENST00000388742.4_Missense_Mutation_p.E470K|EYA1_ENST00000388743.2_Missense_Mutation_p.E469K|EYA1_ENST00000388741.2_Missense_Mutation_p.E436K	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	470					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GCTTCAATTTCGGCCCTCAAC	0.527000													45	58					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104896997	104896997	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:104896997G>A	ENST00000533400.1	-	9	1238	c.1203C>T	c.(1201-1203)ttC>ttT	p.F401F	CASP1_ENST00000598974.1_Silent_p.F401F|CASP1_ENST00000594519.1_Silent_p.F260F|CASP1_ENST00000593315.1_Silent_p.F380F|CASP1_ENST00000534497.1_Silent_p.F260F|CASP1_ENST00000353247.5_Silent_p.F85F|CASP1_ENST00000531166.1_Silent_p.F85F|CASP1_ENST00000527979.1_Silent_p.F364F|CASP1_ENST00000525825.1_Silent_p.F380F|CASP1_ENST00000526568.1_Silent_p.F308F|CASP1_ENST00000446369.1_Silent_p.F260F|CASP1_ENST00000436863.3_Silent_p.F401F|CASP1_ENST00000415981.2_Silent_p.F85F|CASP1_ENST00000393136.4_Silent_p.F380F	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	401					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	AATGTCCTGGGAAGAGGTAGA	0.453000													36	51					0	0	1	0	0
SLC39A13	91252	broad.mit.edu	37	11	47431683	47431683	+	Missense_Mutation	SNP	G	G	A	rs148165667		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:47431683G>A	ENST00000524928.1	+	1	48	c.38G>A	c.(37-39)gGc>gAc	p.G13D	SLC39A13_ENST00000531974.1_Missense_Mutation_p.G13D|SLC39A13_ENST00000362021.4_Missense_Mutation_p.G13D|SLC39A13_ENST00000354884.4_Missense_Mutation_p.G13D|SLC39A13_ENST00000533076.1_Missense_Mutation_p.G13D			Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter), member 13	13					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|kidney(1)|lung(1)|prostate(1)	4				Lung(87;0.0936)		GGCATGGCGGGCCCAAGGCTC	0.642000													66	96					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102490116	102490116	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:102490116C>T	ENST00000413150.2	+	21	2325	c.2270C>T	c.(2269-2271)tCc>tTc	p.S757F	MAP4K4_ENST00000456652.1_Missense_Mutation_p.S641F|MAP4K4_ENST00000347699.4_Missense_Mutation_p.S842F|MAP4K4_ENST00000350198.4_Missense_Mutation_p.S761F|MAP4K4_ENST00000324219.4_Missense_Mutation_p.S923F|MAP4K4_ENST00000350878.4_Missense_Mutation_p.S882F|MAP4K4_ENST00000302217.5_Missense_Mutation_p.S645F|MAP4K4_ENST00000425019.1_Missense_Mutation_p.S875F	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	842					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CAGACTCAGTCCGCTAGTAGC	0.348000													8	13					0	0	1	0	0
ARNTL2	56938	broad.mit.edu	37	12	27554551	27554551	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:27554551C>T	ENST00000544915.1	+	11	1479	c.1260C>T	c.(1258-1260)ttC>ttT	p.F420F	ARNTL2_ENST00000546179.1_Silent_p.F417F|RP11-165P7.1_ENST00000500498.2_RNA|ARNTL2_ENST00000266503.5_Silent_p.F454F|ARNTL2_ENST00000395901.2_Silent_p.F417F|ARNTL2_ENST00000542388.1_Silent_p.F369F|ARNTL2_ENST00000261178.5_Silent_p.F406F|ARNTL2_ENST00000311001.5_Silent_p.F440F	NM_020183.4	NP_064568.3	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear translocator-like 2	454	PAS 2.				circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	21	Colorectal(261;0.0847)|Lung SC(9;0.184)					GGTTTAGTTTCACAAATCCTT	0.294000													31	36					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178358896	178358896	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:178358896C>T	ENST00000361362.2	+	5	1112	c.582C>T	c.(580-582)gcC>gcT	p.A194A	ZFP2_ENST00000523286.1_Silent_p.A194A|ZFP2_ENST00000503510.2_Silent_p.A194A|ZFP2_ENST00000520301.1_Silent_p.A194A	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GTGGCAAAGCCTTCCATAAGA	0.403000													30	49					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15853535	15853535	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:15853535G>A	ENST00000338282.6	-	12	1405	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F	MYH11_ENST00000576790.1_Silent_p.F433F|MYH11_ENST00000452625.2_Silent_p.F440F|MYH11_ENST00000396324.3_Silent_p.F440F|MYH11_ENST00000300036.5_Silent_p.F433F	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	433	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GTATCCAGCGGAAAAGGCGCT	0.537000			T	CBFB	AML								46	78					0	0	1	0	0
WDR5	11091	broad.mit.edu	37	9	137013422	137013422	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:137013422C>T	ENST00000358625.3	+	8	712	c.541C>T	c.(541-543)Cgt>Tgt	p.R181C	WDR5_ENST00000425041.1_Missense_Mutation_p.R181C	NM_017588.2	NP_060058.1	P61964	WDR5_HUMAN	WD repeat domain 5	181					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		TCATTTTAATCGTGATGGATC	0.373000													48	102					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139163629	139163629	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:139163629A>G	ENST00000395297.1	-	13	3259	c.3089T>C	c.(3088-3090)gTt>gCt	p.V1030A		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1030										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TAAGTTCACAACCTCCACAGC	0.527000										HNSCC(54;0.14)			24	71					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20931479	20931479	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:20931479C>T	ENST00000375071.3	+	2	395	c.213C>T	c.(211-213)atC>atT	p.I71I	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	71					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	GGACCGCTATCCAGAAGGCCG	0.512000													10	22					0	0	1	0	0
E2F7	144455	broad.mit.edu	37	12	77417947	77417947	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:77417947G>A	ENST00000322886.7	-	13	2819	c.2584C>T	c.(2584-2586)Ccc>Tcc	p.P862S	E2F7_ENST00000416496.2_Missense_Mutation_p.P720L	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	862					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						ATGCTCTTGGGGGTCACTGGA	0.458000													29	51					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793721	17793721	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:17793721C>T	ENST00000379472.3	+	2	1110	c.1080C>T	c.(1078-1080)gcC>gcT	p.A360A	KCNC1_ENST00000265969.6_Silent_p.A360A	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	360						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						TGATCTTCGCCACCATGATCT	0.607000													38	48					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170917670	170917670	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:170917670G>A	ENST00000272793.5	+	34	4917	c.4867G>A	c.(4867-4869)Gaa>Aaa	p.E1623K	UBR3_ENST00000418381.1_Missense_Mutation_p.E1623K|UBR3_ENST00000392631.1_Missense_Mutation_p.E444K			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1623					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						GTTATACCATGAAGAAGGAAC	0.299000													33	75					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96291710	96291710	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:96291710C>T	ENST00000277165.6	+	9	1776	c.1582C>T	c.(1582-1584)Cca>Tca	p.P528S	FAM120A_ENST00000340893.4_Missense_Mutation_p.P528S|FAM120A_ENST00000375389.3_Missense_Mutation_p.P528S|FAM120A_ENST00000333936.5_Missense_Mutation_p.P556S	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	528						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CACTGTCCAGCCAATCCCGTG	0.622000													15	54					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2702161	2702161	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:2702161C>T	ENST00000324666.5	+	17	3740	c.3389C>T	c.(3388-3390)cCc>cTc	p.P1130L	FAM193A_ENST00000502458.1_Missense_Mutation_p.P1152L|FAM193A_ENST00000505311.1_Missense_Mutation_p.P1130L|FAM193A_ENST00000382839.3_Missense_Mutation_p.P1130L|FAM193A_ENST00000545951.1_Missense_Mutation_p.P1130L	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	1130										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						CCCACCTCTCCCGGTGAGCAT	0.473000													27	52					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19474632	19474632	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:19474632G>A	ENST00000396229.2	+	7	1928	c.1179G>A	c.(1177-1179)caG>caA	p.Q393Q	TMC5_ENST00000542583.2_Silent_p.Q393Q|TMC5_ENST00000564959.1_Silent_p.Q76Q|TMC5_ENST00000541464.1_Silent_p.Q393Q|TMC5_ENST00000561503.1_Silent_p.Q34Q|TMC5_ENST00000219821.5_Silent_p.Q147Q|TMC5_ENST00000381414.4_Silent_p.Q393Q	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	393						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AAAGCAAACAGACCCATCGTA	0.393000													68	64					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44672328	44672328	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:44672328C>T	ENST00000454036.1	+	10	1439	c.1363C>T	c.(1363-1365)Ccc>Tcc	p.P455S	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Missense_Mutation_p.P432S	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	455					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GAAGTCAATCCCCACTGGCAC	0.617000													49	99					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61829912	61829912	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:61829912G>A	ENST00000280772.1	-	37	10918	c.10727C>T	c.(10726-10728)cCa>cTa	p.P3576L	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3576					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGTTGTTGCTGGAGAGCGGTC	0.478000													40	58					0	0	1	0	0
DLST	1743	broad.mit.edu	37	14	75359558	75359558	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:75359558C>T	ENST00000334220.4	+	8	525	c.464C>T	c.(463-465)cCg>cTg	p.P155L	DLST_ENST00000334212.6_Missense_Mutation_p.P69L|DLST_ENST00000555190.1_3'UTR	NM_001933.4	NP_001924.2	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	155					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(234;0.00698)		AAGGCCAAGCCGGCTGAAGCT	0.537000													39	61					0	0	1	0	0
CNTD2	79935	broad.mit.edu	37	19	40732318	40732318	+	Silent	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:40732318T>C	ENST00000430325.2	-	1	279	c.231A>G	c.(229-231)gaA>gaG	p.E77E	CNTD2_ENST00000433940.1_Silent_p.E77E	NM_024877.3	NP_079153.2	B4DX65	B4DX65_HUMAN	cyclin N-terminal domain containing 2	77					regulation of cyclin-dependent protein kinase activity		protein kinase binding			lung(1)|prostate(1)	2						CGTACTCGCGTTCTCCCTGCA	0.741000													8	31					0	0	1	0	0
REG3G	130120	broad.mit.edu	37	2	79254180	79254180	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:79254180C>T	ENST00000272324.5	+	4	400	c.216C>T	c.(214-216)ccC>ccT	p.P72P	REG3G_ENST00000393897.2_Silent_p.P72P|REG3G_ENST00000409471.1_Intron	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	72	C-type lectin.				acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGAAGCGGCCCTCTGGAAAAC	0.562000													52	150					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3351157	3351157	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:3351157G>A	ENST00000602557.1	-	12	1994	c.1439C>T	c.(1438-1440)tCg>tTg	p.S480L	CSMD1_ENST00000539096.1_Missense_Mutation_p.S479L|CSMD1_ENST00000537824.1_Missense_Mutation_p.S479L|CSMD1_ENST00000520002.1_Missense_Mutation_p.S480L|CSMD1_ENST00000602723.1_Missense_Mutation_p.S480L|CSMD1_ENST00000400186.3_Missense_Mutation_p.S480L|CSMD1_ENST00000542608.1_Missense_Mutation_p.S479L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	480	CUB 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTACAAGACCGATCTGGTGTC	0.507000													6	7					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24193193	24193193	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:24193193G>A	ENST00000437154.2	+	14	1645	c.1606G>A	c.(1606-1608)Gaa>Aaa	p.E536K	RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000540823.1_Missense_Mutation_p.E303K|ADAM28_ENST00000265769.4_Intron|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000397649.3_Intron|RP11-624C23.1_ENST00000518988.1_RNA	NM_021777.3	NP_068547.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	0	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATGTGCGAAGGAAAATCATTT	0.473000													5	6					0	0	1	0	0
IGHV6-1	28385	broad.mit.edu	37	14	106406033	106406033	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:106406033G>A	ENST00000390593.2	-	0	75																											GCACGGGCAGGAAGATGAGGA	0.557000													17	34					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55285036	55285036	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:55285036C>T	ENST00000336077.6	+	3	362	c.322C>T	c.(322-324)Ccc>Tcc	p.P108S	CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR2DL1_ENST00000291633.7_Missense_Mutation_p.P108S|KIR2DL3_ENST00000434419.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000402254.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	108					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity	p.P108>?(1)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		TACTCACTCCCCCTATCAGGT	0.517000													161	342					0	0	1	0	0
METTL14	57721	broad.mit.edu	37	4	119613141	119613141	+	Silent	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:119613141A>T	ENST00000388822.4	+	5	497	c.330A>T	c.(328-330)acA>acT	p.T110T	METTL14_ENST00000506780.1_Silent_p.T72T			Q9HCE5	MTL14_HUMAN	methyltransferase like 14	110						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						TTTAGGGAACACAGAGCTTAA	0.328000													42	92					0	0	1	0	0
NCR3	259197	broad.mit.edu	37	6	31557875	31557875	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:31557875G>A	ENST00000376073.4	-	2	335	c.72C>T	c.(70-72)ccC>ccT	p.P24P	NCR3_ENST00000376071.4_Silent_p.P24P|NCR3_ENST00000376072.3_Silent_p.P24P|NCR3_ENST00000340027.5_Silent_p.P24P|NCR3_ENST00000491161.1_5'UTR	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	24	Ig-like.				cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						GAATCTCAGGGGGCTGGGACA	0.572000													26	23					0	0	1	0	0
C14orf39	317761	broad.mit.edu	37	14	60938167	60938167	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:60938167G>A	ENST00000321731.3	-	7	681	c.522C>T	c.(520-522)ccC>ccT	p.P174P		NM_174978.2	NP_777638.2	Q08AQ4	Q08AQ4_HUMAN	chromosome 14 open reading frame 39	174										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		GTGATGGAAAGGGAGCAGGCA	0.234000													10	24					0	0	1	0	0
SPATA7	55812	broad.mit.edu	37	14	88892794	88892794	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:88892794C>T	ENST00000556553.1	+	6	1054	c.495C>T	c.(493-495)gcC>gcT	p.A165A	SPATA7_ENST00000356583.5_Silent_p.A165A|SPATA7_ENST00000045347.7_Silent_p.A197A|SPATA7_ENST00000393545.4_Silent_p.A197A			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	197			S -> N (in dbSNP:rs17124662).		response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						GCTCTGGAGCCCTGTATGGCA	0.517000													59	76					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73747167	73747167	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:73747167C>T	ENST00000200181.3	+	30	3955	c.3768C>T	c.(3766-3768)tgC>tgT	p.C1256C	ITGB4_ENST00000339591.3_Silent_p.C1256C|ITGB4_ENST00000579662.1_Silent_p.C1256C|ITGB4_ENST00000450894.3_Silent_p.C1256C|ITGB4_ENST00000449880.2_Silent_p.C1256C	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1256	Fibronectin type-III 2.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGAGGTCTGCTATGGCCTGG	0.597000													45	65					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43893731	43893731	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:43893731C>T	ENST00000450892.2	-	24	4641	c.4564G>A	c.(4564-4566)Gga>Aga	p.G1522R	STRC_ENST00000541030.1_Missense_Mutation_p.G749R	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1522					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GGACGAAATCCCCGGGGGGGA	0.532000													27	63					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247557	164247557	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:164247557C>T	ENST00000296533.2	-	2	681	c.150G>A	c.(148-150)gtG>gtA	p.V50V	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	50					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CAAGAATGATCACAGCTCCAT	0.408000													46	81					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88380192	88380192	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:88380192C>T	ENST00000298699.2	-	10	999	c.817_splice	c.e10-1	p.M273_splice	C12orf50_ENST00000550553.1_Splice_Site_p.V234_splice	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	273										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						GGACATCATTCACTTAGAAAA	0.338000													23	33					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18393501	18393501	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:18393501G>A	ENST00000338745.6	-	10	3496	c.1762C>T	c.(1762-1764)Cca>Tca	p.P588S	SATB1_ENST00000417717.2_Missense_Mutation_p.P588S|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Missense_Mutation_p.P588S	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	588					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TGCTCTGCTGGAACATGGATA	0.463000													41	93					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208391105	208391105	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:208391105C>T	ENST00000367033.3	-	2	920	c.163G>A	c.(163-165)Gtc>Atc	p.V55I		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	55	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CCTTGGTGGACGGTCAAGTGG	0.607000													65	192					0	0	1	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180968	142180968	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:142180968G>A	ENST00000390368.2	-	0	48																											GCTGCATGACGGAGGGGTCTT	0.582000													13	35					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95570079	95570079	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:95570079G>A	ENST00000526495.1	-	23	3945	c.3654C>T	c.(3652-3654)tcC>tcT	p.S1218S	DICER1_ENST00000541352.1_Silent_p.S1218S|DICER1_ENST00000393063.1_Silent_p.S1218S|DICER1_ENST00000556045.1_Silent_p.S116S|DICER1_ENST00000527414.1_Silent_p.S1218S|DICER1_ENST00000343455.3_Silent_p.S1218S			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1218					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AATTCTGAATGGAATATGAGG	0.403000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				58	107					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37442503	37442503	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:37442503C>T	ENST00000374660.1	+	13	1642	c.1543C>T	c.(1543-1545)Ctc>Ttc	p.L515F	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.L515F|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.L515F			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	571						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TTAACAGAGTCTCTGTGAGAC	0.279000													24	218					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98377303	98377303	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:98377303C>T	ENST00000186436.5	-	37	5192	c.4964G>A	c.(4963-4965)gGc>gAc	p.G1655D		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1655						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						AGTGGGGTTGCCGTTCTTGCC	0.537000													4	108					0	0	1	0	0
OR5AU1	390445	broad.mit.edu	37	14	21624050	21624050	+	Silent	SNP	G	G	A	rs143241393		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:21624050G>A	ENST00000304418.3	-	1	172	c.135C>T	c.(133-135)atC>atT	p.I45I		NM_001004731.1	NP_001004731.1	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU, member 1	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		AGTGCTCTGCGATGGAGAAAG	0.527000													57	80					0	0	1	0	0
SCARNA2	677766	broad.mit.edu	37	1	109643058	109643058	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:109643058C>T	ENST00000458748.1	+	0	244					NR_003023.1																						AGCTCTCCTCCTGCGAAGCCC	0.706000													15	38					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283440	40283440	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:40283440C>T	ENST00000325157.6	-	2	563	c.313G>A	c.(313-315)Gat>Aat	p.D105N		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	105	ENTH.									breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					TGCTGAAAATCTTTTAGTGTT	0.393000													63	96					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542280	55542280	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:55542280C>T	ENST00000220676.1	+	4	5986	c.5838C>T	c.(5836-5838)ttC>ttT	p.F1946F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1946					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGAAAATTTCTTGGGTTTTT	0.343000													44	76					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25339112	25339112	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:25339112C>T	ENST00000546682.1	+	0	1101				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						CTGGTGGATCCCTCAGGATGG	0.473000													23	33					0	0	1	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39380174	39380174	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:39380174G>A	ENST00000402182.3	+	2	167	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	APOBEC3B_ENST00000407298.3_Missense_Mutation_p.E38K|APOBEC3B_ENST00000333467.3_Missense_Mutation_p.E38K			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	38					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					GCTGTGCTATGAAGTGAAAAT	0.488000													34	60					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949267	89949267	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:89949267C>T	ENST00000405460.2	+	20	3972	c.3876C>T	c.(3874-3876)ttC>ttT	p.F1292F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1292					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCAGTGAGTTCCCTGCTGGTT	0.468000													21	35					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106121864	106121864	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:106121864G>A	ENST00000369704.3	+	3	509	c.375G>A	c.(373-375)gaG>gaA	p.E125E	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	125										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		CTCTGAAAGAGGAAATAGTGA	0.468000													21	22					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166179959	166179959	+	Silent	SNP	C	C	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:166179959C>A	ENST00000357398.3	+	12	2255	c.1965C>A	c.(1963-1965)tcC>tcA	p.S655S	SCN2A_ENST00000283256.6_Silent_p.S655S|SCN2A_ENST00000375427.2_Silent_p.S655S|SCN2A_ENST00000375437.2_Silent_p.S655S			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	655					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTGTGGTCTCCCTGGTCGGGG	0.577000													22	20					0.00229938	0.00230814	1	1	0
C14orf39	317761	broad.mit.edu	37	14	60938168	60938168	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:60938168G>A	ENST00000321731.3	-	7	680	c.521C>T	c.(520-522)cCc>cTc	p.P174L		NM_174978.2	NP_777638.2	Q08AQ4	Q08AQ4_HUMAN	chromosome 14 open reading frame 39	174										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		TGATGGAAAGGGAGCAGGCAC	0.229000													10	24					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374370	95374370	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:95374370C>T	ENST00000494840.1	-	0	1491					NR_077228.1																						CAAACACTTTCGTCCTACATT	0.453000													32	64					0	0	1	0	0
SOX10	6663	broad.mit.edu	37	22	38369841	38369841	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:38369841G>A	ENST00000396884.2	-	4	1344	c.1062C>T	c.(1060-1062)gcC>gcT	p.A354A	SOX10_ENST00000360880.2_Silent_p.A354A|POLR2F_ENST00000405557.1_Intron|POLR2F_ENST00000407936.1_Intron	NM_006941.3	NP_008872.1	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	354						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity			NS(6)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|skin(2)	20	Melanoma(58;0.045)					TCTTCACCTGGGCTTTGGCAT	0.672000													27	34					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123593968	123593968	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:123593968C>T	ENST00000340011.5	+	3	701	c.344C>T	c.(343-345)cCc>cTc	p.P115L	SPAM1_ENST00000402183.2_Missense_Mutation_p.P115L|SPAM1_ENST00000223028.7_Missense_Mutation_p.P115L|SPAM1_ENST00000439500.1_Missense_Mutation_p.P115L|SPAM1_ENST00000460182.1_Missense_Mutation_p.P115L	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	115					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	GGAGGAATCCCCCAGAAGATT	0.398000													47	85					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28409178	28409178	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:28409178C>T	ENST00000337532.5	-	11	1108	c.832G>A	c.(832-834)Gaa>Aaa	p.E278K	MPP7_ENST00000375732.1_Missense_Mutation_p.E278K|MPP7_ENST00000445954.2_Missense_Mutation_p.E153K|MPP7_ENST00000540098.1_Missense_Mutation_p.E278K|MPP7_ENST00000375719.3_Missense_Mutation_p.E278K	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	278	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						GCATCAGCTTCGTGTTTCGCT	0.463000													45	58					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228246797	228246797	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:228246797C>T	ENST00000284523.1	+	4	768	c.690C>T	c.(688-690)ttC>ttT	p.F230F	WNT3A_ENST00000366753.2_Silent_p.F230F	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	230					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				TCGGTGACTTCCTCAAGGACA	0.642000													61	38					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103018164	103018164	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:103018164C>T	ENST00000306312.3	-	18	2129	c.1868G>A	c.(1867-1869)aGc>aAc	p.S623N	SLC26A5_ENST00000354356.4_Missense_Mutation_p.S56N|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000393729.1_Missense_Mutation_p.S586N|SLC26A5_ENST00000339444.6_Missense_Mutation_p.S623N|SLC26A5_ENST00000393735.2_Intron|SLC26A5_ENST00000393727.1_Missense_Mutation_p.S625N|SLC26A5_ENST00000393723.1_Missense_Mutation_p.S593N|SLC26A5_ENST00000393730.1_Missense_Mutation_p.S591N|SLC26A5_ENST00000432958.2_Missense_Mutation_p.S591N	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	623	STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						AGGAAATGTGCTTTTGATCAC	0.403000													47	81					0	0	1	0	0
SMR3B	10879	broad.mit.edu	37	4	71255422	71255422	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:71255422G>A	ENST00000304915.3	+	3	246	c.97G>A	c.(97-99)Gga>Aga	p.G33R	SMR3B_ENST00000504825.1_Missense_Mutation_p.G33R	NM_006685.3	NP_006676.1			submaxillary gland androgen regulated protein 3B											large_intestine(2)|lung(3)|skin(2)	7		all_hematologic(202;0.196)				ATATCCACCTGGACCGCTGGC	0.512000													54	83					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008249	120008249	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:120008249G>A	ENST00000341846.5	-	1	912	c.491C>T	c.(490-492)tCc>tTc	p.S164F		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	164					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GCCGGACTTGGACCGTGAAAA	0.647000													64	87					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253104	124253104	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:124253104T>C	ENST00000375013.2	-	1	154	c.136A>G	c.(136-138)Atc>Gtc	p.I46V		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AAAAGAGTGATCAAGCCAAGG	0.428000													58	147					0	0	1	0	0
PMS2CL	441194	broad.mit.edu	37	7	6776901	6776901	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:6776901C>T	ENST00000486256.1	+	0	1028					NR_002217.1																						AAGGAGCCCTCTAGGACAGAA	0.522000													33	49					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53459239	53459239	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:53459239G>A	ENST00000331173.4	-	1	116	c.71C>T	c.(70-72)cCa>cTa	p.P24L	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373985.1_Intron|PRKG1_ENST00000373980.4_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	24	RRM.				mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		TGCCTCATATGGAATGTTCCC	0.522000													100	168					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45833861	45833861	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr21:45833861G>A	ENST00000397928.1	+	20	3495	c.3050G>A	c.(3049-3051)aGg>aAg	p.R1017K	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.R997K|TRPM2_ENST00000397932.2_Missense_Mutation_p.R1017K|TRPM2_ENST00000300482.5_Missense_Mutation_p.R1017K	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1017						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ACGCAGCAGAGGCCGGCCTTC	0.607000													207	333					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106710531	106710531	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:106710531G>A	ENST00000283148.7	-	15	1326	c.1229C>T	c.(1228-1230)cCc>cTc	p.P410L	UXS1_ENST00000409032.1_Missense_Mutation_p.P237L|UXS1_ENST00000540130.1_Missense_Mutation_p.P348L|UXS1_ENST00000409501.3_Missense_Mutation_p.P405L	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	405					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						CTTTGGTTTGGGGATGTACTG	0.448000													28	48					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762478	24762478	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:24762478G>A	ENST00000376451.2	+	2	582	c.322G>A	c.(322-324)Gag>Aag	p.E108K	KIAA1217_ENST00000430453.2_Missense_Mutation_p.E311K|KIAA1217_ENST00000376454.3_Missense_Mutation_p.E390K|KIAA1217_ENST00000376462.1_Missense_Mutation_p.E310K|KIAA1217_ENST00000458595.1_Missense_Mutation_p.E390K|KIAA1217_ENST00000396446.1_Missense_Mutation_p.E108K|KIAA1217_ENST00000307544.6_Missense_Mutation_p.E108K|KIAA1217_ENST00000396445.1_Missense_Mutation_p.E108K|KIAA1217_ENST00000376452.3_Missense_Mutation_p.E390K			Q5T5P2	SKT_HUMAN	KIAA1217	390					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GTACAGAAATGAGGGTTTCTA	0.488000													62	107					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123900690	123900690	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:123900690C>T	ENST00000431524.1	+	1	394	c.361C>T	c.(361-363)Cgc>Tgc	p.R121C		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GTCCTGTGATCGCTACCTGGC	0.562000													76	132					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338795	13338795	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:13338795G>A	ENST00000602906.1	+	0	583																				kidney(3)|lung(1)	4						TAAGGCagaggaagagaaagg	0.433000													9	12					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101659801	101659801	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:101659801C>T	ENST00000342239.3	-	7	2668	c.2577G>A	c.(2575-2577)cgG>cgA	p.R859R	DNMBP_ENST00000543621.1_Silent_p.R105R|DNMBP_ENST00000324109.4_Silent_p.R859R			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	859	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CAAGCTCATCCCGGTGACCAA	0.413000													52	79					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396841	154396841	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:154396841C>T	ENST00000435029.4	+	1	3582	c.3422C>T	c.(3421-3423)tCc>tTc	p.S1141F		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1141	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCCGAAGGCTCCTTCAAACTG	0.537000													38	52					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57170069	57170069	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:57170069G>A	ENST00000371244.4	+	7	1280	c.1214G>A	c.(1213-1215)gGa>gAa	p.G405E		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	405					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TGGCATCTTGGAATCCGAAGT	0.418000													38	60					0	0	1	0	0
SETD3	84193	broad.mit.edu	37	14	99866533	99866533	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:99866533G>A	ENST00000331768.5	-	12	1400	c.1241C>T	c.(1240-1242)tCg>tTg	p.S414L		NM_032233.2	NP_115609.2	Q86TU7	SETD3_HUMAN	SET domain containing 3	414					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				AGGAAATTCCGAGTTCCCCAA	0.388000													59	80					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	813731	813731	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:813731C>T	ENST00000297440.6	+	10	1998	c.1978C>T	c.(1978-1980)Ccc>Tcc	p.P660S	HEATR2_ENST00000313147.5_Missense_Mutation_p.P660S|HEATR2_ENST00000403952.3_Missense_Mutation_p.P85S	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	660							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CATCCTGGCCCCCAATCTGCA	0.652000													58	110					0	0	1	0	0
CRHBP	1393	broad.mit.edu	37	5	76259219	76259219	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:76259219G>A	ENST00000274368.4	+	6	1167	c.745G>A	c.(745-747)Gga>Aga	p.G249R	CRHBP_ENST00000514258.1_3'UTR	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	249					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		GCTGCTGGGAGGAACTGGATT	0.463000													70	133					0	0	1	0	0
ZNF253	56242	broad.mit.edu	37	19	19990950	19990950	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:19990950C>T	ENST00000589717.1	+	3	313	c.221C>T	c.(220-222)cCc>cTc	p.P74L	ZNF253_ENST00000355650.4_Intron	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	74	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATTGCCAAACCCCCAGGTAGG	0.398000													34	73					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6174305	6174305	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:6174305G>A	ENST00000261405.5	-	11	1545	c.1291C>T	c.(1291-1293)Cag>Tag	p.Q431*		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	431	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AAGCTCACCTGGACAGTCTCA	0.587000													21	33					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88767442	88767442	+	RNA	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:88767442T>C	ENST00000444431.1	+	0	2690				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CCATACTTGATGAACAGTTAT	0.303000													66	142					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14282274	14282274	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:14282274G>A	ENST00000310358.7	+	0	2507							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GGAGCAGGTGGAGAAGTGCAT	0.577000													22	51					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63412632	63412632	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:63412632G>A	ENST00000330258.3	-	2	807	c.535C>T	c.(535-537)Cac>Tac	p.H179Y	AMER1_ENST00000374869.3_Missense_Mutation_p.H179Y|AMER1_ENST00000403336.1_Missense_Mutation_p.H179Y	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									CTCTTCCGGTGACGGCGGATA	0.577000													47	10					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120840528	120840528	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:120840528G>A	ENST00000273666.6	+	7	917	c.646G>A	c.(646-648)Gat>Aat	p.D216N	STXBP5L_ENST00000492541.1_Missense_Mutation_p.D216N|STXBP5L_ENST00000497029.1_Missense_Mutation_p.D216N|STXBP5L_ENST00000471454.1_Missense_Mutation_p.D216N|STXBP5L_ENST00000472879.1_Missense_Mutation_p.D216N	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	216					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ACATTTAAGCGATAGCCCAAG	0.294000													34	62					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135977358	135977358	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:135977358G>A	ENST00000393160.3	-	15	2366	c.2013C>T	c.(2011-2013)ttC>ttT	p.F671F	RALGDS_ENST00000372062.3_Silent_p.F697F|RALGDS_ENST00000393157.3_Silent_p.F725F|RALGDS_ENST00000469972.1_5'UTR|RALGDS_ENST00000542690.1_Silent_p.F797F|RALGDS_ENST00000372047.3_Silent_p.F714F|RALGDS_ENST00000372050.3_Silent_p.F726F	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	726					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		ACTCCGGGACGAAGCTGATGT	0.612000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								3	7					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50832089	50832089	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr18:50832089G>A	ENST00000442544.2	+	13	2669	c.2053_splice	c.e13+1	p.G685_splice	DCC_ENST00000581580.1_Splice_Site_p.G340_splice|DCC_ENST00000412726.1_Splice_Site_p.G533_splice	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	685	Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCTATTCACAGGTCAGTGTTC	0.403000													45	79					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94692559	94692559	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:94692559G>A	ENST00000258526.4	+	27	4475	c.4226G>A	c.(4225-4227)tGg>tAg	p.W1409*	PLXNC1_ENST00000545312.1_Nonsense_Mutation_p.W148*|PLXNC1_ENST00000547057.1_Nonsense_Mutation_p.W456*	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1409					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GTACATATTTGGAAAACAAAC	0.363000													18	41					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18436239	18436239	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:18436239G>A	ENST00000338745.6	-	7	2655	c.921C>T	c.(919-921)ctC>ctT	p.L307L	SATB1_ENST00000417717.2_Silent_p.L307L|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Silent_p.L307L	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	307					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GTGTTGATACGAGCCCAGGGT	0.572000													47	81					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28592617	28592617	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:28592617A>G	ENST00000380982.4	-	20	2609	c.2528T>C	c.(2527-2529)gTt>gCt	p.V843A	FLT3_ENST00000241453.7_Missense_Mutation_p.V843A|FLT3_ENST00000537084.1_Intron			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	843	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GCCCCTGACAACATAGTTGGA	0.458000			"""Mis, O"""		"""AML, ALL"""								33	50					0	0	1	0	0
ASZ1	136991	broad.mit.edu	37	7	117067454	117067454	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:117067454C>T	ENST00000284629.2	-	1	123	c.61G>A	c.(61-63)Gag>Aag	p.E21K		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	21					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity	p.E21K(1)		breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CCATCATCCTCGCTCTCGCTA	0.672000											OREG0003439	type=REGULATORY REGION|Gene=ASZ1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	60	102					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87454249	87454249	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:87454249A>C	ENST00000268616.4	-	5	720	c.503T>G	c.(502-504)gTg>gGg	p.V168G		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	168					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GTTTCGCTCCACATAAAATGC	0.562000													15	32					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46727245	46727245	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:46727245G>A	ENST00000311764.2	+	5	2225	c.1995G>A	c.(1993-1995)gaG>gaA	p.E665E		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	665					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ACAGAGAGGAGGAAGTCTCCC	0.612000													15	23					0	0	1	0	0
ZCCHC7	84186	broad.mit.edu	37	9	37349404	37349404	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:37349404C>T	ENST00000336755.5	+	7	1144	c.1038C>T	c.(1036-1038)gcC>gcT	p.A346A	ZCCHC7_ENST00000534928.1_Silent_p.A56A|ZCCHC7_ENST00000461038.1_3'UTR	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	346							nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		GACCATCAGCCTTAGCATATT	0.428000													50	80					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92088079	92088079	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:92088079C>T	ENST00000256343.3	-	19	2289	c.2133G>A	c.(2131-2133)tgG>tgA	p.W711*		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	711					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				AATATATTTTCCATGTTCGTC	0.368000													50	96					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101576625	101576625	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:101576625C>T	ENST00000536262.2	-	9	1679	c.1121G>A	c.(1120-1122)aGa>aAa	p.R374K		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	374					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGAGAGCGATCTGAAGTAAGG	0.363000													32	54					0	0	1	0	0
C4orf40	401137	broad.mit.edu	37	4	71024057	71024057	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:71024057G>A	ENST00000344526.5	+	3	277	c.88G>A	c.(88-90)Gat>Aat	p.D30N	C4orf40_ENST00000502441.2_Intron|C4orf40_ENST00000502294.1_Missense_Mutation_p.D30N	NM_214711.3	NP_999876.2	Q6MZM9	CD040_HUMAN	chromosome 4 open reading frame 40	30						extracellular region				breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						TGACAATGACGATGGTCACCC	0.388000													64	134					0	0	1	0	0
SNORD114-2	767578	broad.mit.edu	37	14	101418202	101418202	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:101418202G>A	ENST00000363953.1	+	0	10					NR_003194.1																						TGGGACCAATGATAATGACTG	0.328000													26	55					0	0	1	0	0
TAS2R40	259286	broad.mit.edu	37	7	142920020	142920020	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:142920020C>T	ENST00000408947.3	+	1	891	c.849C>T	c.(847-849)atC>atT	p.I283I		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	283					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					TGTGCAAGATCATCATGGCTG	0.468000													48	100					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233349798	233349798	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:233349798G>A	ENST00000304546.1	-	4	1069	c.859C>T	c.(859-861)Ctg>Ttg	p.L287L	ECEL1_ENST00000409941.1_Silent_p.L287L	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	287					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TATGCTGCCAGGATCTGCACC	0.647000													20	37					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817431	69817431	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:69817431G>A	ENST00000251566.4	-	1	78	c.48C>T	c.(46-48)ttC>ttT	p.F16F		NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	16						integral to membrane	glucuronosyltransferase activity	p.F16F(1)		NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGCCAACACAGAAGAGCTGCA	0.473000													25	72					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412034	126412034	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:126412034C>T	ENST00000394329.3	+	17	14070	c.14057C>T	c.(14056-14058)tCc>tTc	p.S4686F	FAT4_ENST00000335110.5_Missense_Mutation_p.S2927F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4686					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGAACCAGCTCCCTAAGCCAC	0.527000													56	126					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93303020	93303020	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:93303020C>T	ENST00000370321.3	+	6	625	c.535C>T	c.(535-537)Cga>Tga	p.R179*		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	179					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TAGTACCAAACGATTCCCTGG	0.358000													27	46					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659988	50659988	+	Missense_Mutation	SNP	G	G	A	rs143587106		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:50659988G>A	ENST00000439308.2	-	16	3292	c.2800C>T	c.(2800-2802)Cct>Tct	p.P934S	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Missense_Mutation_p.P934S	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	934					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCCTCCCCAGGAGCTGAGGGG	0.657000													6	17					0	0	1	0	0
C5AR2	27202	broad.mit.edu	37	19	47845019	47845019	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:47845019G>A	ENST00000595464.1	+	2	1181	c.963G>A	c.(961-963)gtG>gtA	p.V321V	C5AR2_ENST00000600626.1_Silent_p.V321V|C5AR2_ENST00000257267.2_Silent_p.V321V	NM_001271749.1	NP_001258678.1			complement component 5a receptor 2																		ACGAAAGTGTGGACAGCAAGA	0.557000													29	66					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982613	7982613	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:7982613G>A	ENST00000328600.2	-	2	707	c.546C>T	c.(544-546)ctC>ctT	p.L182L		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	182	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTTTTCTGGCGAGAGTTGTCT	0.532000													29	53					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10532971	10532971	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:10532971G>A	ENST00000583535.1	-	40	5826	c.5739C>T	c.(5737-5739)atC>atT	p.I1913I	MYH3_ENST00000226209.7_Silent_p.I1913I	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1913					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GAGATTCTGCGATATCCGCAC	0.567000													49	70					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61467860	61467860	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:61467860G>A	ENST00000343916.3	+	29	1582	c.1579G>A	c.(1579-1581)Gag>Aag	p.E527K	COL9A3_ENST00000462700.1_Intron	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	527	Nonhelical region 3 (NC3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GCGCATCAGGGAGCTGTGTGG	0.672000													8	27					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17277176	17277176	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:17277176C>T	ENST00000544301.1	+	7	1430	c.1017C>T	c.(1015-1017)tcC>tcT	p.S339S	VIM_ENST00000224237.5_Silent_p.S339S	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	339	Coil 2.|Rod.			S -> C (in Ref. 17; AAA61281).	cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton	p.S339S(1)|p.L340M(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGAATGAGTCCCTGGAACGCC	0.458000													24	43					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6700892	6700892	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:6700892C>T	ENST00000309577.6	-	21	3353	c.3190G>A	c.(3190-3192)Gag>Aag	p.E1064K	CHD4_ENST00000544484.1_Missense_Mutation_p.E1061K|CHD4_ENST00000357008.2_Missense_Mutation_p.E1064K|CHD4_ENST00000544040.1_Missense_Mutation_p.E1057K			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1064	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TGCCCACCCTCCTTAAGGTTC	0.468000													61	73					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40704302	40704302	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:40704302G>A	ENST00000253055.3	+	2	991	c.703G>A	c.(703-705)Gag>Aag	p.E235K	MAP3K10_ENST00000593906.1_3'UTR	NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	235	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GGAGGCCATCGAGAACCACAA	0.637000													35	60					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179468872	179468872	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:179468872C>T	ENST00000589042.1	-	282	54766	c.54542G>A	c.(54541-54543)gGa>gAa	p.G18181E	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G9241E|TTN_ENST00000591111.1_Missense_Mutation_p.G16540E|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G15613E|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G9116E|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G9308E|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16540	Ig-like 105.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGCATTGATCCTTTGGTGCG	0.463000													66	107					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856740	53856740	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:53856740A>C	ENST00000458035.1	+	4	2929	c.2812A>C	c.(2812-2814)Act>Cct	p.T938P	ZNF845_ENST00000595091.1_Missense_Mutation_p.T938P	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	938					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GACAATTCATACTGGAGAGAA	0.353000													10	42					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50250699	50250699	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:50250699C>T	ENST00000246801.3	-	5	692	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	204							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		TCAGCATCTTCCACAGACCGG	0.572000													37	68					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389635	20389635	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:20389635G>A	ENST00000315915.4	+	1	895	c.870G>A	c.(868-870)agG>agA	p.R290R		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATACACTAAGGAATAGGGATA	0.398000													67	127					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													8	73					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129065	6129065	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:6129065C>T	ENST00000316529.3	+	1	152	c.57C>T	c.(55-57)atC>atT	p.I19I		NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCAGTTCATCCTGATGGGAT	0.502000													42	58					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52496389	52496389	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:52496389C>T	ENST00000216286.5	-	10	2276	c.2277G>A	c.(2275-2277)ccG>ccA	p.P759P	NID2_ENST00000541773.1_Silent_p.P706P	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	759	EGF-like 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					AAGGATTCCCCGGAGTGGGGT	0.517000													24	42					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17046556	17046556	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:17046556G>A	ENST00000492551.1	-	0	96					NR_026567.1																						GCCGCGGTGGGATCCCCACCG	0.597000													34	300					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11648317	11648317	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:11648317G>A	ENST00000262442.3	+	31	6383	c.6315G>A	c.(6313-6315)cgG>cgA	p.R2105R	DNAH9_ENST00000454412.2_Silent_p.R2105R	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2105					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ATGTCCCCCGGAGGAGAGACC	0.537000													23	51					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122004448	122004448	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:122004448C>T	ENST00000265922.3	-	4	917	c.456G>A	c.(454-456)agG>agA	p.R152R	DBC1_ENST00000373964.2_Silent_p.R152R	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		152	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TCCCTGACTTCCTGTCGAGGC	0.488000													23	56					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18218412	18218412	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:18218412C>T	ENST00000262811.5	+	2	55	c.55C>T	c.(55-57)Cca>Tca	p.P19S		NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	19							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						GCTGAGCCTGCCACGCCGAGG	0.572000													89	125					0	0	1	0	0
LECT1	11061	broad.mit.edu	37	13	53277900	53277900	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr13:53277900C>T	ENST00000448904.2	-	7	942	c.832G>A	c.(832-834)Gaa>Aaa	p.E278K	LECT1_ENST00000377962.3_Missense_Mutation_p.E279K	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	279					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		CAGATTCCTTCGTGATCCAGT	0.453000													45	82					0	0	1	0	0
BRAT1	221927	broad.mit.edu	37	7	2583262	2583262	+	Silent	SNP	G	G	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:2583262G>T	ENST00000340611.4	-	5	1021	c.765C>A	c.(763-765)gcC>gcA	p.A255A		NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	255					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						ACGAGTGTGCGGCGGGGATGG	0.692000													31	79					9.78485e-24	9.90704e-24	1	1	0
TSIX	9383	broad.mit.edu	37	X	73041549	73041549	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:73041549G>A	ENST00000604411.1	+	0	29510				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TTTAAAAACGGAAAAGGTCAA	0.358000													5	1					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99564731	99564731	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:99564731G>A	ENST00000292401.4	-	4	928	c.792C>T	c.(790-792)tcC>tcT	p.S264S	AZGP1_ENST00000483612.1_5'UTR|AZGP1_ENST00000411734.1_3'UTR	NM_001185.3	NP_001176.1	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	264	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCACCACCCAGGACTGGTAAG	0.637000													23	70					0	0	1	0	0
STMN2	11075	broad.mit.edu	37	8	80567234	80567234	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:80567234G>A	ENST00000220876.7	+	4	799	c.417G>A	c.(415-417)atG>atA	p.M139I	STMN2_ENST00000518111.1_Missense_Mutation_p.M139I|STMN2_ENST00000518491.1_Missense_Mutation_p.M128I	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	139					intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			TCCTGAAAATGGAACAAATTA	0.453000													22	30					0	0	1	0	0
UBTF	7343	broad.mit.edu	37	17	42287823	42287823	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:42287823C>T	ENST00000302904.4	-	14	1870	c.1378G>A	c.(1378-1380)Gag>Aag	p.E460K	UBTF_ENST00000393606.3_Missense_Mutation_p.E423K|UBTF_ENST00000529383.1_Missense_Mutation_p.E460K|UBTF_ENST00000436088.1_Missense_Mutation_p.E460K|UBTF_ENST00000526094.1_Missense_Mutation_p.E423K|UBTF_ENST00000533177.1_Missense_Mutation_p.E423K|UBTF_ENST00000343638.5_Missense_Mutation_p.E423K|CTB-175E5.7_ENST00000586560.1_RNA|UBTF_ENST00000527034.1_Missense_Mutation_p.E423K			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I	460					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		AGCGCCGCCTCTCGGGCCTTG	0.731000											OREG0024456	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	25					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541990	55541990	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:55541990C>T	ENST00000220676.1	+	4	5696	c.5548C>T	c.(5548-5550)Cat>Tat	p.H1850Y		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1850					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AATAGCAAATCATCATACAGA	0.418000													30	56					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17086005	17086005	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:17086005G>A	ENST00000443236.1	-	17	2144	c.2113C>T	c.(2113-2115)Cct>Tct	p.P705S	CPAMD8_ENST00000388925.4_Missense_Mutation_p.P444S	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	658						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CACCAAAAAGGACCATCCTCC	0.567000													5	25					0	0	1	0	0
SLC39A13	91252	broad.mit.edu	37	11	47431682	47431682	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:47431682G>A	ENST00000524928.1	+	1	47	c.37G>A	c.(37-39)Ggc>Agc	p.G13S	SLC39A13_ENST00000531974.1_Missense_Mutation_p.G13S|SLC39A13_ENST00000362021.4_Missense_Mutation_p.G13S|SLC39A13_ENST00000354884.4_Missense_Mutation_p.G13S|SLC39A13_ENST00000533076.1_Missense_Mutation_p.G13S			Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter), member 13	13					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|kidney(1)|lung(1)|prostate(1)	4				Lung(87;0.0936)		TGGCATGGCGGGCCCAAGGCT	0.642000													65	101					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46727246	46727246	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:46727246G>A	ENST00000311764.2	+	5	2226	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	666					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAGAGAGGAGGAAGTCTCCCC	0.612000													15	24					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818728	159818728	+	RNA	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:159818728G>A	ENST00000497452.1	-	0	517																											CAAAGTAGGAGGGAACGAAGT	0.522000													69	109					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39645780	39645780	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:39645780C>T	ENST00000216832.4	+	3	302	c.235C>T	c.(235-237)Ctt>Ttt	p.L79F	PNN_ENST00000553331.1_Missense_Mutation_p.L79F|PNN_ENST00000556530.1_Missense_Mutation_p.L79F	NM_002687.3	NP_002678.2	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	79	Necessary for interaction with RNPS1.|Necessary for interactions with KRT8, KRT18 and KRT19.|Necessary for mediating alternative 5' splicing.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		ACAGAGAGACCTTGAAGGGGC	0.368000													8	30					0	0	1	0	0
ZNF781	163115	broad.mit.edu	37	19	38160384	38160384	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:38160384G>A	ENST00000358582.4	-	4	1414	c.666C>T	c.(664-666)ttC>ttT	p.F222F	ZFP30_ENST00000586732.1_Intron|ZNF781_ENST00000590008.1_Silent_p.F222F	NM_152605.3	NP_689818.2	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24						TCACCAGTATGAATTCTTTGA	0.358000													42	73					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766382	77766382	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:77766382C>T	ENST00000521891.2	+	10	7673	c.7225C>T	c.(7225-7227)Ccc>Tcc	p.P2409S	ZFHX4_ENST00000455469.2_Missense_Mutation_p.P2364S|ZFHX4_ENST00000518282.1_Missense_Mutation_p.P2383S|ZFHX4_ENST00000050961.6_Missense_Mutation_p.P2364S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2364	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCTGAATATCCCGCAGAAAA	0.572000										HNSCC(33;0.089)			11	22					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277116	152277116	+	Missense_Mutation	SNP	C	C	T	rs140368354		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:152277116C>T	ENST00000368799.1	-	3	10281	c.10246G>A	c.(10246-10248)Gag>Aag	p.E3416K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3416	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGCCTGCTCGTGGTGGGAT	0.597000									Ichthyosis				362	261					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003539	122003539	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:122003539C>T	ENST00000498619.1	+	7	3206	c.2768C>T	c.(2767-2769)tCc>tTc	p.S923F	CASR_ENST00000490131.1_Missense_Mutation_p.S913F|CASR_ENST00000296154.5_Missense_Mutation_p.S913F	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	913					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCCTCCTCCTCCATCAGCAGC	0.662000													25	50					0	0	1	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28961033	28961033	+	RNA	SNP	T	T	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:28961033T>G	ENST00000417404.1	+	0	1291				SMURF2P1_ENST00000578265.1_RNA|LRRC37BP1_ENST00000412831.1_RNA																							AGTTCCAGGATATGACTATAA	0.264000													4	67					0	0	1	0	0
PCOLCE	5118	broad.mit.edu	37	7	100203371	100203371	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:100203371T>C	ENST00000223061.5	+	5	941	c.661T>C	c.(661-663)Ttc>Ctc	p.F221L		NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	221	CUB 2.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GGTCAGCGTGTTCAACGGAGC	0.687000													6	5					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67269850	67269850	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:67269850C>T	ENST00000356404.3	-	4	553	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	PITPNM1_ENST00000436757.2_Missense_Mutation_p.E110K|PITPNM1_ENST00000534749.1_Missense_Mutation_p.E110K	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	110					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						GTCTCAATTTCAATGGAGAAT	0.617000													56	91					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38697707	38697707	+	Silent	SNP	A	A	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:38697707A>G	ENST00000449981.2	+	4	664	c.555A>G	c.(553-555)aaA>aaG	p.K185K	DNAH8_ENST00000359357.3_Intron					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTTTTGCGAAAGATGGTTGTA	0.338000													5	3					0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97217112	97217112	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:97217112G>A	ENST00000454558.2	+	7	1820	c.643G>A	c.(643-645)Ggg>Agg	p.G215R	ARID5A_ENST00000357485.3_Missense_Mutation_p.G283R			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	283					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						CTGCCGCCATGGGGCAGAGCC	0.652000													12	24					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73787560	73787560	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:73787560G>A	ENST00000342056.2	+	5	1266	c.868G>A	c.(868-870)Gat>Aat	p.D290N	KCNQ5_ENST00000403813.2_Missense_Mutation_p.D290N|KCNQ5_ENST00000402622.2_Missense_Mutation_p.D290N|KCNQ5_ENST00000370392.1_Missense_Mutation_p.D290N|KCNQ5_ENST00000414165.2_Missense_Mutation_p.D290N|KCNQ5_ENST00000370398.1_Missense_Mutation_p.D290N|KCNQ5_ENST00000355635.3_Missense_Mutation_p.D290N|KCNQ5_ENST00000355194.4_Missense_Mutation_p.D290N	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	290					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GGTGGAAAAGGATGCCAATAA	0.318000													33	13					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98001786	98001786	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:98001786C>T	ENST00000355273.2	+	1	55	c.55C>T	c.(55-57)Ctc>Ttc	p.L19F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						AGAGTTTGTTCTCACAGGACT	0.413000													116	165					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85676482	85676482	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:85676482G>A	ENST00000322366.6	-	34	5903	c.5496C>T	c.(5494-5496)atC>atT	p.I1832I	WDFY3_ENST00000295888.4_Silent_p.I1832I			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1832						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATACGTTATGGATAGAAGAGA	0.433000													41	55					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545982	82545982	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:82545982C>T	ENST00000423517.2	-	7	11657	c.11320G>A	c.(11320-11322)Gaa>Aaa	p.E3774K	PCLO_ENST00000437081.1_Missense_Mutation_p.E494K|PCLO_ENST00000333891.8_Missense_Mutation_p.E3774K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3705					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GACTCCCTTTCCACAAGATCA	0.453000													34	56					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138377800	138377800	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:138377800A>T	ENST00000356818.2	+	4	1993	c.1444A>T	c.(1444-1446)Atg>Ttg	p.M482L	PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000401470.3_Missense_Mutation_p.M482L|PPP1R26_ENST00000604351.1_Missense_Mutation_p.M482L|PPP1R26_ENST00000605660.1_Missense_Mutation_p.M482L|PPP1R26_ENST00000605286.1_Missense_Mutation_p.M482L	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	482						nucleolus	protein binding										TGCTGAGCTGATGTGTGCAGA	0.607000													38	60					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585826	82585826	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:82585826T>G	ENST00000423517.2	-	5	4780	c.4443A>C	c.(4441-4443)aaA>aaC	p.K1481N	PCLO_ENST00000333891.8_Missense_Mutation_p.K1481N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1412					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTTGGCTATCTTTTTTAAAAG	0.358000													27	44					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36499159	36499159	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:36499159C>T	ENST00000342292.4	-	1	534	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	172						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGGATGGTTTCCTCCCCAGTC	0.622000													34	66					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117609901	117609901	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:117609901C>T	ENST00000368508.3	-	43	6996	c.6798G>A	c.(6796-6798)acG>acA	p.T2266T	ROS1_ENST00000368507.3_Silent_p.T2260T	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2266					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTCGGTTCTTCGTTTCCATTA	0.393000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								20	18					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976683	4976683	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:4976683G>A	ENST00000380371.1	-	1	260	c.261C>T	c.(259-261)ttC>ttT	p.F87F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CATTGAACAGGAAGATGCTTA	0.463000													71	25					0	0	1	0	0
ANKRD32	84250	broad.mit.edu	37	5	94030913	94030913	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:94030913C>T	ENST00000265140.5	+	21	3492	c.3073C>T	c.(3073-3075)Ctt>Ttt	p.L1025F	ANKRD32_ENST00000493934.1_Intron	NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	1025										NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CCCACACATTCTTAAGGAACT	0.413000													99	151					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21032525	21032525	+	Missense_Mutation	SNP	G	G	A	rs141602442		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:21032525G>A	ENST00000381545.3	+	11	1510	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.E431K|LST3_ENST00000540229.1_Missense_Mutation_p.E431K|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.E431K|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	431					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TCTAATCTGCGAAAGCAAATC	0.303000													30	45					0	0	1	0	0
IFT57	55081	broad.mit.edu	37	3	107885727	107885727	+	Missense_Mutation	SNP	G	G	A	rs149049643		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:107885727G>A	ENST00000264538.3	-	8	1202	c.955C>T	c.(955-957)Cgt>Tgt	p.R319C	IFT57_ENST00000468021.1_5'UTR	NM_018010.3	NP_060480.1	Q9NWB7	IFT57_HUMAN	intraflagellar transport 57 homolog (Chlamydomonas)	319					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	14			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TGAGCTGCACGATATTCTTGA	0.373000													26	59					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164494	139164494	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr8:139164494C>T	ENST00000395297.1	-	13	2394	c.2224G>A	c.(2224-2226)Ggc>Agc	p.G742S		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	742										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCTGGATGCCGCTTGGCAAA	0.522000										HNSCC(54;0.14)			35	59					0	0	1	0	0
SLC39A9	55334	broad.mit.edu	37	14	69925297	69925297	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:69925297G>A	ENST00000031146.4	+	6	1391	c.713G>A	c.(712-714)gGa>gAa	p.G238E	SLC39A9_ENST00000556605.1_Intron|SLC39A9_ENST00000555245.1_3'UTR|SLC39A9_ENST00000336643.5_Missense_Mutation_p.G304E|SLC39A9_ENST00000557046.1_Missense_Mutation_p.G281E			Q9NUM3	S39A9_HUMAN	solute carrier family 39, member 9	304					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|skin(1)|stomach(1)	14				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		CTGTCAGTAGGACACCAGCAT	0.592000													16	17					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5951255	5951255	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:5951255G>A	ENST00000379999.5	+	6	1275	c.1171G>A	c.(1171-1173)Ggg>Agg	p.G391R	FBXO18_ENST00000379994.1_Missense_Mutation_p.G77R|FBXO18_ENST00000362091.4_Missense_Mutation_p.G340R|FBXO18_ENST00000397269.3_5'UTR|FBXO18_ENST00000470089.1_3'UTR	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	340					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						CGCTGCTGCCGGGGTAGGTCT	0.567000													24	36					0	0	1	0	0
CENPN	55839	broad.mit.edu	37	16	81051405	81051405	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:81051405C>T	ENST00000305850.5	+	5	1110	c.320C>T	c.(319-321)tCg>tTg	p.S107L	CENPN_ENST00000428963.2_Missense_Mutation_p.S107L|CENPN_ENST00000299572.5_Missense_Mutation_p.S107L|CENPN_ENST00000439957.3_Missense_Mutation_p.S87L|CENPN_ENST00000393335.3_Missense_Mutation_p.S107L|CMC2_ENST00000565914.1_Intron|CENPN_ENST00000569461.1_Intron|RP11-303E16.3_ENST00000562315.1_RNA	NM_001100624.2|NM_001270474.1	NP_001094094.2|NP_001257403.1	Q96H22	CENPN_HUMAN	centromere protein N	107					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm		p.S107L(1)		breast(1)|large_intestine(5)|lung(4)	10						TTTAAAAATTCGTTCAAGAAA	0.279000													26	40					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143792731	143792731	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:143792731C>T	ENST00000408949.2	+	1	591	c.531C>T	c.(529-531)ttC>ttT	p.F177F		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					ACCACTTTTTCTGTCAAATCA	0.468000													62	98					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112769679	112769679	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:112769679C>T	ENST00000390666.3	-	1	1049	c.858G>A	c.(856-858)aaG>aaA	p.K286K	CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA|MCC_ENST00000408903.3_Intron	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	286					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TCTCCCCCTCCTTGTTGATGG	0.632000													19	33					0	0	1	0	0
BMP4	652	broad.mit.edu	37	14	54417526	54417526	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:54417526C>T	ENST00000245451.4	-	4	844	c.451G>A	c.(451-453)Gag>Aag	p.E151K	BMP4_ENST00000417573.1_Missense_Mutation_p.E151K|BMP4_ENST00000559087.1_Missense_Mutation_p.E151K|BMP4_ENST00000558984.1_Missense_Mutation_p.E151K	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4	151					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						GAGATCACCTCGTTCTCAGGG	0.512000													39	49					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528638	20528638	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:20528638G>A	ENST00000315683.1	+	1	435	c.435G>A	c.(433-435)gcG>gcA	p.A145A		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AGGGGTTTGCGATACTTTCAT	0.388000													74	115					0	0	1	0	0
SLC7A11	23657	broad.mit.edu	37	4	139101888	139101888	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:139101888G>A	ENST00000280612.5	-	10	1452	c.1173C>T	c.(1171-1173)ttC>ttT	p.F391F		NM_014331.3	NP_055146.1	Q9UPY5	XCT_HUMAN	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	391					blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)	18	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	CAAAACTGAGGAAATTCAAAA	0.458000													16	21					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106960879	106960879	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:106960879G>A	ENST00000369701.3	+	16	2356	c.2127_splice	c.e16-1	p.G710_splice	SORCS3_ENST00000369699.4_5'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	710						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTCTCTAAGGGAGAGCCTTGT	0.438000													31	50					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38812793	38812793	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:38812793C>T	ENST00000449082.2	-	4	575	c.576G>A	c.(574-576)ctG>ctA	p.L192L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	192					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CGCTAAAATCCAGCCAGTTCC	0.443000													56	118					0	0	1	0	0
PBX4	80714	broad.mit.edu	37	19	19681608	19681608	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:19681608G>A	ENST00000251203.8	-	3	514	c.228C>T	c.(226-228)ccC>ccT	p.P76P		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	76							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						GGGCGTCAGGGGGATCTTCGT	0.547000													31	68					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234454596	234454596	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:234454596C>T	ENST00000366618.3	+	6	1199	c.1054C>T	c.(1054-1056)Cct>Tct	p.P352S	SLC35F3_ENST00000366617.3_Missense_Mutation_p.P283S	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	283					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CACCTGCATTCCTATTATCCT	0.418000													91	249					0	0	1	0	0
KCNJ10	3766	broad.mit.edu	37	1	160011958	160011958	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:160011958G>A	ENST00000368089.3	-	2	591	c.365C>T	c.(364-366)tCc>tTc	p.S122F	KCNJ10_ENST00000509700.1_5'UTR	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	122						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGATTCAAGGGAGAAGAGGAA	0.582000													107	80					0	0	1	0	0
TMEM182	130827	broad.mit.edu	37	2	103380833	103380833	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:103380833C>T	ENST00000412401.2	+	3	483	c.278C>T	c.(277-279)cCg>cTg	p.P93L	TMEM182_ENST00000486293.1_3'UTR|TMEM182_ENST00000409528.1_5'UTR|TMEM182_ENST00000409173.1_Missense_Mutation_p.P50L	NM_144632.3	NP_653233.3	Q6ZP80	TM182_HUMAN	transmembrane protein 182	93						integral to membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11						TACCTGTCTCCGTACCCCTTC	0.473000													9	94					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125530481	125530481	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:125530481C>T	ENST00000241305.3	-	8	1207	c.1053G>A	c.(1051-1053)ctG>ctA	p.L351L	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	351					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CATACAGCTTCAGGCCCTGGT	0.463000													169	277					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24475350	24475350	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:24475350G>A	ENST00000230036.1	-	5	550	c.441_splice	c.e5+1	p.A147_splice	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	147						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TGTACTCACAGCTCCCATGGT	0.433000													90	82					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31288249	31288249	+	Silent	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:31288249C>T	ENST00000544665.3	+	11	1163	c.1092C>T	c.(1090-1092)ccC>ccT	p.P364P	ITGAM_ENST00000287497.8_Silent_p.P364P	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	364					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						AGAATGGCCCCTTGCTGAGCA	0.498000													11	16					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983330	97983330	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:97983330G>A	ENST00000383696.2	+	1	243	c.202G>A	c.(202-204)Gac>Aac	p.D68N	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CATCTGGAAAGACCCTCACCT	0.423000													144	216					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5951256	5951256	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:5951256G>A	ENST00000379999.5	+	6	1276	c.1173_splice	c.e6+1	p.G391_splice	FBXO18_ENST00000379994.1_Splice_Site_p.G77_splice|FBXO18_ENST00000362091.4_Splice_Site_p.G340_splice|FBXO18_ENST00000397269.3_5'UTR|FBXO18_ENST00000470089.1_3'UTR	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	340					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						GCTGCTGCCGGGGTAGGTCTG	0.562000													25	36					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204587954	204587954	+	Silent	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:204587954G>A	ENST00000367175.1	-	1	3379	c.1167C>T	c.(1165-1167)ttC>ttT	p.F389F	LRRN2_ENST00000367177.3_Silent_p.F389F|LRRN2_ENST00000367176.3_Silent_p.F389F			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	389	LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GCGGCTCGATGAAGCGGACAC	0.667000													40	106					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3265946	3265946	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:3265946C>T	ENST00000576468.1	+	0	418																											TGGACAATTTCCTCCTGGCTG	0.512000													32	71					0	0	1	0	0
SNX18	112574	broad.mit.edu	37	5	53814866	53814866	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:53814866C>T	ENST00000343017.6	+	1	1278	c.1084C>T	c.(1084-1086)Cac>Tac	p.H362Y	SNX18_ENST00000381410.4_Missense_Mutation_p.H362Y|SNX18_ENST00000326277.3_Missense_Mutation_p.H362Y	NM_001145427.1	NP_001138899.1	Q96RF0	SNX18_HUMAN	sorting nexin 18	362	PX.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding			endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	18		Lung NSC(810;3.46e-05)|Breast(144;0.102)				GTGGATGAACCACATGGCCAG	0.637000													27	47					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19856891	19856891	+	RNA	SNP	C	C	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:19856891C>T	ENST00000548109.1	+	0	72																											GTTTAATTAGCCCAACTTCTG	0.368000													5	61					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54876398	54876398	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:54876398G>A	ENST00000434277.2	-	1	204	c.14C>T	c.(13-15)cCc>cTc	p.P5L	LAIR1_ENST00000348231.4_Missense_Mutation_p.P5L|LAIR1_ENST00000474878.1_Missense_Mutation_p.P5L|LAIR1_ENST00000391742.2_Missense_Mutation_p.P5L|LAIR1_ENST00000391743.3_Intron|LAIR1_ENST00000313038.6_Intron|LAIR1_ENST00000463489.1_Intron	NM_002287.3	NP_002278.1	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	5						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		GAGGGCGGTGGGGTGGGGAGA	0.632000													30	61					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142668385	142668385	+	RNA	DEL	G	G	-	rs139797618	by1000genomes	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:142668385delG	ENST00000369381.2	-	0	2507																											gagaggtaatgtgcaggctgg	0.527													4	9	---	---	---	---					
SCNM1	79005	broad.mit.edu	37	1	151139586	151139606	+	Splice_Site	DEL	TTTCTCCTCAGGCTTGCAGCT	TTTCTCCTCAGGCTTGCAGCT	-	rs147425600		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:151139586_151139606delTTTCTCCTCAGGCTTGCAGCT	ENST00000368905.4	+	4	322_332	c.211_splice	c.e4-1	p.71_splice	SCNM1_ENST00000461862.1_3'UTR	NM_001204856.1|NM_024041.3	NP_001191785.1|NP_076946.1	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	71					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTGTTTCCCTTTCTCCTCAGGCTTGCAGCTTTTCTATGGC	0.448													37	89	---	---	---	---					
RP11-815M8.1	0	broad.mit.edu	37	1	222087585	222087585	+	RNA	DEL	G	G	-	rs11342851	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:222087585delG	ENST00000433576.1	-	0	230																											AATGAATATTGGCTAATGTCA	0.388													4	3	---	---	---	---					
TAF1A	9015	broad.mit.edu	37	1	222742985	222742985	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr1:222742985delT	ENST00000350027.4	-	7	914	c.761delA	c.(760-762)gtfs	p.D254fs	TAF1A_ENST00000465263.1_5'UTR|TAF1A_ENST00000366890.1_Frame_Shift_Del_p.D140fs|TAF1A_ENST00000352967.4_Frame_Shift_Del_p.D254fs|TAF1A_ENST00000543857.1_Frame_Shift_Del_p.D254fs|TAF1A_ENST00000391882.1_Frame_Shift_Del_p.D140fs	NM_001201536.1	NP_001188465.1	Q15573	TAF1A_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	254					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding			kidney(3)|large_intestine(3)|lung(11)|urinary_tract(1)	18				GBM - Glioblastoma multiforme(131;0.0186)		TTGGGCTCCATCTCGATCCCC	0.338													58	63	---	---	---	---					
AC008069.1	0	broad.mit.edu	37	2	16939179	16939179	+	RNA	DEL	G	G	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:16939179delG	ENST00000448650.1	+	0	56																											CCTTCCTCCAGGAAGTTTTCC	0.488											OREG0014457	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89100923	89100924	+	RNA	INS	-	-	G			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:89100923_89100924insG	ENST00000393525.3	+	0	1397_1398																											AATATAAAAAAGATACATATGA	0.282													2	4	---	---	---	---					
AC012307.2	0	broad.mit.edu	37	2	96812443	96812443	+	RNA	DEL	C	C	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:96812443delC	ENST00000449242.1	-	0	142																											CTCCTCCGTGCCCTCTGAAAG	0.662													2	4	---	---	---	---					
EDAR	10913	broad.mit.edu	37	2	109524342	109524342	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:109524342delA	ENST00000409271.1	-	10	1476	c.1033delT	c.(1033-1035)ctfs	p.S345fs	EDAR_ENST00000258443.2_Frame_Shift_Del_p.S313fs|EDAR_ENST00000376651.1_Frame_Shift_Del_p.S345fs			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	313					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CTGGTGGCAGACTTCTCCCTG	0.617													47	117	---	---	---	---					
AC133785.1	0	broad.mit.edu	37	2	131593897	131593897	+	RNA	DEL	G	G	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:131593897delG	ENST00000429282.1	-	0	670				AC133785.1_ENST00000446213.2_RNA																							aaaggtaagtgggaggcaaga	0.552													2	4	---	---	---	---					
SCN2A	6326	broad.mit.edu	37	2	166245578	166245578	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr2:166245578delC	ENST00000375437.2	+	27	5552	c.5262delC	c.(5260-5262)ttfs	p.F1756fs	SCN2A_ENST00000375427.2_Frame_Shift_Del_p.F1756fs|SCN2A_ENST00000357398.3_Frame_Shift_Del_p.F1756fs|SCN2A_ENST00000283256.6_Frame_Shift_Del_p.F1756fs	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1756					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TTGGGATTTTCTTTTTTGTCA	0.453													12	305	---	---	---	---					
RP11-384L8.1	0	broad.mit.edu	37	3	32279413	32279413	+	RNA	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:32279413delT	ENST00000565519.1	-	0	657																											TCTTGAAACATTTTTTTTCCC	0.542													2	4	---	---	---	---					
TMCC1	23023	broad.mit.edu	37	3	129370576	129370578	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr3:129370576_129370578delCTG	ENST00000393238.3	-	6	2048_2050	c.1708_1710delCAG	c.(1708-1710)del	p.Q570del	TMCC1_ENST00000329333.5_In_Frame_Del_p.Q391del|TMCC1_ENST00000432054.2_In_Frame_Del_p.Q246del|TMCC1_ENST00000426664.2_In_Frame_Del_p.Q456del	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	570						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						GCTGCACCACCTGCTGCTGCTGC	0.581													7	171	---	---	---	---					
ADGRL3-AS1	101927186	broad.mit.edu	37	4	62960109	62960109	+	RNA	DEL	A	A	-	rs71213030		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:62960109delA	ENST00000506704.1	-	0	456				RP11-84A1.3_ENST00000504135.1_RNA|RP11-84A1.3_ENST00000509461.1_RNA																							gtggggtatgaaaaaaaactc	0.542													4	2	---	---	---	---					
RP11-742B18.1	0	broad.mit.edu	37	4	88586288	88586289	+	RNA	INS	-	-	A	rs59297849		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:88586288_88586289insA	ENST00000506480.1	-	0	322				RP11-742B18.1_ENST00000507894.1_RNA																							ctcaaaaaaagaaaaaaaaaaa	0.426													4	2	---	---	---	---					
LOC101927087	101927087	broad.mit.edu	37	4	125453843	125453843	+	RNA	DEL	G	G	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:125453843delG	ENST00000563724.1	-	0	263																											TAAAAATATAGGAGAGGTTAT	0.408													2	4	---	---	---	---					
RP11-18H21.2	0	broad.mit.edu	37	4	153094968	153094968	+	RNA	DEL	C	C	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr4:153094968delC	ENST00000504799.1	-	0	86																		p.?(1)									AAAATGGTCTCCAAGTGTGCT	0.547													2	4	---	---	---	---					
CTD-2297D10.2	101929176	broad.mit.edu	37	5	5137668	5137669	+	RNA	DEL	CA	CA	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:5137668_5137669delCA	ENST00000512155.1	-	0	99																											TGGGGAGCGCCACACACACACA	0.594													2	4	---	---	---	---					
RP11-124N3.3	0	broad.mit.edu	37	5	19082959	19082959	+	RNA	DEL	G	G	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:19082959delG	ENST00000504827.1	-	0	289																											GAAAGTATGTGGTTGACTTAC	0.323													2	4	---	---	---	---					
MEF2C-AS1	101929423	broad.mit.edu	37	5	88328921	88328922	+	RNA	DEL	TC	TC	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr5:88328921_88328922delTC	ENST00000512585.1	+	0	131				MEF2C-AS1_ENST00000514571.1_RNA|MEF2C-AS1_ENST00000514092.1_RNA|MEF2C-AS1_ENST00000508521.1_RNA																							CTGGATGGGAtctctctctctc	0.470													4	3	---	---	---	---					
LY86-AS1	285780	broad.mit.edu	37	6	6581288	6581289	+	RNA	INS	-	-	A	rs11381372	by1000genomes	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:6581288_6581289insA	ENST00000435641.1	-	0	388				LY86-AS1_ENST00000429345.1_RNA|LY86-AS1_ENST00000447858.1_RNA																							GCAGAGGCCACAGCCAATGAAG	0.441													4	2	---	---	---	---					
LY86-AS1	285780	broad.mit.edu	37	6	6585323	6585324	+	RNA	INS	-	-	CTCCT	rs10660732		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr6:6585323_6585324insCTCCT	ENST00000435641.1	-	0	388				LY86-AS1_ENST00000429345.1_RNA|LY86-AS1_ENST00000447858.1_RNA																							ccccttctctcctcctctcctc	0.545													3	3	---	---	---	---					
RP4-724E13.2	0	broad.mit.edu	37	7	51003024	51003024	+	RNA	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:51003024delT	ENST00000420449.1	+	0	24																											ctttatttccttttttttctt	0.368													2	4	---	---	---	---					
RP11-310H4.1	0	broad.mit.edu	37	7	55651286	55651286	+	RNA	DEL	A	A	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:55651286delA	ENST00000454777.1	+	0	147																											ggtgcccaataactctacatt	0.423													2	4	---	---	---	---					
PMS2P3	5387	broad.mit.edu	37	7	75142142	75142142	+	RNA	DEL	A	A	-	rs35519730		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr7:75142142delA	ENST00000418756.1	-	0	991					NR_028059.1															lung(1)	1						tctcaaaaagaaaaaaaaaaa	0.418													3	3	---	---	---	---					
LOC403323	403323	broad.mit.edu	37	9	66534586	66534587	+	RNA	INS	-	-	C	rs61597357		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:66534586_66534587insC	ENST00000445604.2	-	0	669																											TGAAGCAATTACACATGTTGTC	0.470													3	6	---	---	---	---					
LOC101928438	101928438	broad.mit.edu	37	9	102431636	102431636	+	RNA	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:102431636delT	ENST00000427039.1	-	0	319																											TGGTTCTGCCTTTTACCCAAT	0.388													2	4	---	---	---	---					
RP11-308N19.1	0	broad.mit.edu	37	9	109228522	109228523	+	RNA	INS	-	-	GT	rs35241341	by1000genomes	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr9:109228522_109228523insGT	ENST00000435485.1	+	0	171																											tgtgtgtgtgcgtgtgtgtgtg	0.450													3	4	---	---	---	---					
AL603965.1	0	broad.mit.edu	37	10	47769275	47769275	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr10:47769275delT	ENST00000335083.5	+	2	374	c.96delT	c.(94-96)tgfs	p.C32fs																								GGGGGACTTGTCCCCTGGGAA	0.667													2	4	---	---	---	---					
LOC101927708	101927708	broad.mit.edu	37	11	3518200	3518200	+	RNA	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:3518200delT	ENST00000527970.1	-	0	605				RP13-726E6.1_ENST00000534291.1_lincRNA																							gttcatatagttatgtgtgaa	0.373													2	4	---	---	---	---					
SOX6	55553	broad.mit.edu	37	11	16071289	16071290	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:16071289_16071290insTA	ENST00000528252.1	-	10	1513_1514	c.1323_1324insTA	c.(1321-1326)aagtcafs	p.K441fs	SOX6_ENST00000396356.3_Intron|SOX6_ENST00000352083.6_Intron|SOX6_ENST00000528429.1_Intron|SOX6_ENST00000316399.6_Intron|SOX6_ENST00000527619.1_Frame_Shift_Ins_p.K444fs	NM_001145811.1	NP_001139283.1	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	478					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						TGGTGTTGACTTTTCCATTTAC	0.431													131	218	---	---	---	---					
RP11-750H9.5	0	broad.mit.edu	37	11	47407862	47407862	+	RNA	DEL	T	T	-	rs34641376		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:47407862delT	ENST00000532943.1	-	0	267				RP11-750H9.5_ENST00000532340.1_RNA|RP11-750H9.5_ENST00000527426.1_RNA																							gtgatccccctgccttggcct	0.483													2	4	---	---	---	---					
LOC440040	440040	broad.mit.edu	37	11	49599259	49599259	+	RNA	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:49599259delT	ENST00000527477.1	+	0	1062																											GCAGACTCACTTGTTATGCAG	0.299													2	4	---	---	---	---					
LOC101927226	101927226	broad.mit.edu	37	11	59392386	59392386	+	RNA	DEL	A	A	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:59392386delA	ENST00000531311.1	+	0	59				AP000442.1_ENST00000531108.1_RNA																							actccatctcaaaaaaaaaaa	0.532													2	4	---	---	---	---					
RP11-619A14.3	0	broad.mit.edu	37	11	75926641	75926641	+	RNA	DEL	A	A	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr11:75926641delA	ENST00000531538.1	-	0	39																											CAGGGGAGGTATTGTTATTTT	0.577													2	4	---	---	---	---					
HOTAIR	100124700	broad.mit.edu	37	12	54365254	54365255	+	RNA	INS	-	-	T			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:54365254_54365255insT	ENST00000424518.1	-	0	59				HOTAIR_ENST00000455246.1_RNA	NR_003716.3																						ACAAGCTACAATTTTTTGTGTC	0.406													2	4	---	---	---	---					
RP11-20E24.1	0	broad.mit.edu	37	12	76993076	76993076	+	RNA	DEL	C	C	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr12:76993076delC	ENST00000551082.1	+	0	121																											gggttggggacctctgCTGTA	0.502													2	4	---	---	---	---					
IL25	64806	broad.mit.edu	37	14	23845057	23845058	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:23845057_23845058delTG	ENST00000329715.2	+	2	760_761	c.502_503delTG	c.(502-504)tfs	p.C168fs	IL25_ENST00000397242.2_Frame_Shift_Del_p.C152fs	NM_022789.3	NP_073626.1	Q9H293	IL25_HUMAN	interleukin 25	168					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TTCCTTAGCTTGTGTGTGTGTG	0.604													7	198	---	---	---	---					
RP11-116N8.1	0	broad.mit.edu	37	14	36425913	36425913	+	RNA	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr14:36425913delT	ENST00000550089.1	+	0	242																											CCATTCAACCTTTTTTTCTGA	0.493													2	4	---	---	---	---					
RP11-382A20.5	0	broad.mit.edu	37	15	83749077	83749078	+	RNA	INS	-	-	T	rs111569387		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr15:83749077_83749078insT	ENST00000566841.1	+	0	734				RP11-382A20.6_ENST00000568441.1_RNA																							CAAAAATTCCAttttttttttt	0.450													3	5	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32093362	32093362	+	RNA	DEL	T	T	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:32093362delT	ENST00000566806.1	-	0	499																											TTCAGGTTGCTTTTTTTTTCC	0.438													3	6	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32123215	32123215	+	RNA	DEL	G	G	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:32123215delG	ENST00000564145.1	-	0	456																											tattctagaaGGATAAATTAT	0.343													7	9	---	---	---	---					
LINC01572	101927957	broad.mit.edu	37	16	72658568	72658569	+	RNA	DEL	AC	AC	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr16:72658568_72658569delAC	ENST00000561611.2	-	0	113																											acacacacaaacacacacacac	0.485													2	4	---	---	---	---					
COPS3	8533	broad.mit.edu	37	17	17179429	17179429	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr17:17179429delA	ENST00000539941.2	-	2	253	c.45delT	c.(43-45)ctfs	p.L15fs	COPS3_ENST00000268717.5_Frame_Shift_Del_p.L35fs|COPS3_ENST00000439936.2_Frame_Shift_Del_p.L15fs	NM_001199125.1	NP_001186054.1	Q9UNS2	CSN3_HUMAN	COP9 signalosome subunit 3	35					cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			NS(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						AGTTCTTCGCAAGGAGTTCCC	0.463													34	85	---	---	---	---					
AC007204.2	0	broad.mit.edu	37	19	20055260	20055260	+	RNA	DEL	C	C	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:20055260delC	ENST00000592245.1	+	0	72																											ctgctagccaccctccccttc	0.577													2	4	---	---	---	---					
PRKD2	25865	broad.mit.edu	37	19	47207846	47207847	+	Frame_Shift_Ins	INS	-	-	CC	rs144404837	byFrequency	TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr19:47207846_47207847insCC	ENST00000433867.1	-	5	1048_1049	c.571_572insGG	c.(571-573)ccgfs	p.P191fs	PRKD2_ENST00000291281.4_Frame_Shift_Ins_p.P191fs|PRKD2_ENST00000601806.1_Frame_Shift_Ins_p.P34fs|PRKD2_ENST00000595515.1_Frame_Shift_Ins_p.P191fs|PRKD2_ENST00000600194.1_Frame_Shift_Ins_p.P34fs	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	191					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CCGTTTGCGGGCCCCACTACAG	0.658											OREG0025578	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	58	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29595845	29595845	+	RNA	DEL	A	A	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr20:29595845delA	ENST00000432067.1	-	0	74																											acacagtgagaccttgtccct	0.473													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11048361	11048361	+	RNA	DEL	A	A	-	rs71293628		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr21:11048361delA	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGGGAAGAGAAAAAAACAGG	0.408													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11084479	11084479	+	RNA	DEL	A	A	-	rs112755619		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr21:11084479delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGGGGTCATAAAACCAGAAA	0.413													6	10	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11092161	11092164	+	RNA	DEL	TTTG	TTTG	-	rs142087979		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr21:11092161_11092164delTTTG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCTAGGTTTTTTGTTGTTGtttg	0.402													3	6	---	---	---	---					
LOC101928233	101928233	broad.mit.edu	37	21	44019847	44019847	+	RNA	DEL	G	G	-	rs67573699		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr21:44019847delG	ENST00000419628.1	-	0	1317																											tgtggagggtgggggggggta	0.632													3	4	---	---	---	---					
RP1-231P7P.1	0	broad.mit.edu	37	22	27969425	27969425	+	RNA	DEL	C	C	-	rs35207321		TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:27969425delC	ENST00000415655.1	-	0	66																											CTTTCGAAGAcccccccgctg	0.507													4	3	---	---	---	---					
CTA-833B7.2	0	broad.mit.edu	37	22	37252792	37252792	+	RNA	DEL	A	A	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chr22:37252792delA	ENST00000330602.2	-	0	349																											GGGAGGGACCAAGCCACAGCA	0.463											OREG0026526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
LAMP2	3920	broad.mit.edu	37	X	119602967	119602967	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GN-A4U4-06A-11D-A32N-08	TCGA-GN-A4U4-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e878a6af-4760-42db-a84c-cb18ab32f56a	899c5bb0-7b50-4f87-8773-7cd93a46cf23	g.chrX:119602967delC	ENST00000371335.4	-	1	194	c.58delG	c.(58-60)tcfs	p.V20fs	LAMP2_ENST00000434600.2_Frame_Shift_Del_p.V20fs|LAMP2_ENST00000200639.4_Frame_Shift_Del_p.V20fs|LAMP2_ENST00000538785.1_Frame_Shift_Del_p.V20fs	NM_013995.2	NP_054701.1	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2	20					platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				endometrium(4)|large_intestine(2)|lung(5)|ovary(2)|urinary_tract(2)	15						TCACCCAGGACTAGGCAGACC	0.677													74	13	---	---	---	---					
