Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
TAS1R2	80834	broad.mit.edu	37	1	19181198	19181198	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:19181198G>A	uc001bba.1	-	3	767	c.766C>T	c.(766-768)CGC>TGC	p.R256C		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	256	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GTCACCAGGCGCTGGCGCTCC	0.637000												
E2F2	1870	broad.mit.edu	37	1	23836399	23836399	+	Silent	SNP	G	G	A	rs146034018		TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:23836399G>A	uc001bhe.1	-	7	1715	c.1287C>T	c.(1285-1287)TAC>TAT	p.Y429Y		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	429	Transactivation (Potential).				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CCCCAAGGTCGTAGGAGTCGA	0.622000												
CCDC21	64793	broad.mit.edu	37	1	26566316	26566316	+	Silent	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:26566316C>T	uc001bls.1	+	2	173	c.42C>T	c.(40-42)CAC>CAT	p.H14H	CCDC21_uc001blr.2_Silent_p.H14H|CCDC21_uc010ofa.1_Silent_p.H14H	NM_022778	NP_073615	Q6P2H3	CEP85_HUMAN	coiled-coil domain containing 21	14						centrosome|nucleolus|spindle pole					0		all_cancers(24;7e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.6e-26)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;9.48e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00917)|READ - Rectum adenocarcinoma(331;0.0649)		GGATCTCTCACGTCACTTCAC	0.388000												
ARID1A	8289	broad.mit.edu	37	1	27100357	27100357	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:27100357C>T	uc001bmv.1	+	17	4442	c.4069C>T	c.(4069-4071)CAG>TAG	p.Q1357*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1356*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1357*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q974*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q203*|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1357	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTTCCCCAGCCAGCAGACTAC	0.507000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
C1orf173	127254	broad.mit.edu	37	1	75038657	75038657	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:75038657A>C	uc001dgg.2	-	14	2956	c.2737T>G	c.(2737-2739)TTG>GTG	p.L913V		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	913	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AGATGCTCCAAGTTCAGGGCT	0.542000												
BTBD8	284697	broad.mit.edu	37	1	92573497	92573497	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:92573497G>T	uc001doo.2	+	4	868	c.601G>T	c.(601-603)GTG>TTG	p.V201L	BTBD8_uc010otc.1_RNA	NM_183242	NP_899065	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	201						nucleus				ovary(1)	1		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		GAAGCTTTATGTGAAACCTTG	0.318000												
CD160	11126	broad.mit.edu	37	1	145699047	145699047	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:145699047G>A	uc001eol.1	-	5	662	c.444C>T	c.(442-444)CAC>CAT	p.H148H	NBPF10_uc001emp.3_Intron|CD160_uc001eom.1_Silent_p.H39H|CD160_uc010oyz.1_RNA	NM_007053	NP_008984	O95971	BY55_HUMAN	CD160 antigen precursor	148					cell proliferation|cell surface receptor linked signaling pathway|cellular defense response|regulation of immune response	anchored to plasma membrane	MHC class I receptor activity|receptor binding				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TGAACTCAAGGTGTTGTCTTT	0.468000												
FLG	2312	broad.mit.edu	37	1	152280800	152280800	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:152280800T>G	uc001ezu.1	-	3	6598	c.6562A>C	c.(6562-6564)AGT>CGT	p.S2188R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2188	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTTGCACTTCTGGATCCT	0.532000									Ichthyosis			
FCRL3	115352	broad.mit.edu	37	1	157667628	157667628	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:157667628T>G	uc001frb.2	-	5	672	c.380A>C	c.(379-381)AAC>ACC	p.N127T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.N127T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Missense_Mutation_p.N127T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	127	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TTGATGAGTGTTTTTGTTGTC	0.408000												
OR10R2	343406	broad.mit.edu	37	1	158449668	158449668	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:158449668A>T	uc010pik.1	+	1	1	c.1A>T	c.(1-3)ATG>TTG	p.M1L	uc001fso.1_Intron	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					aaagGAGTGCATGCCCCAAAT	0.224000												
SELP	6403	broad.mit.edu	37	1	169564011	169564011	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:169564011C>G	uc001ggi.3	-	13	2271	c.2206G>C	c.(2206-2208)GAG>CAG	p.E736Q	SELP_uc001ggh.2_Missense_Mutation_p.E571Q|SELP_uc009wvr.2_Missense_Mutation_p.E736Q	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	736	Extracellular (Potential).|Sushi 9.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	AACTGGCCCTCTAGACAATGG	0.458000												
FAM5B	57795	broad.mit.edu	37	1	177250278	177250278	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:177250278A>G	uc001glf.2	+	8	2278	c.1966A>G	c.(1966-1968)AGC>GGC	p.S656G	FAM5B_uc001glg.2_Missense_Mutation_p.S551G	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	656						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCTGGATGACAGCTCCAATGA	0.458000												
CACNA1E	777	broad.mit.edu	37	1	181727164	181727164	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:181727164G>A	uc001gow.2	+	31	4576	c.4411G>A	c.(4411-4413)GTG>ATG	p.V1471M	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1359M|CACNA1E_uc001gox.1_Missense_Mutation_p.V697M|CACNA1E_uc009wxt.2_Missense_Mutation_p.V697M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1471	IV.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCAGTACCGCGTGTGGCACTT	0.532000												
PLXNA2	5362	broad.mit.edu	37	1	208390683	208390683	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:208390683G>A	uc001hgz.2	-	2	1343	c.585C>T	c.(583-585)TTC>TTT	p.F195F	PLXNA2_uc001hha.3_Silent_p.F249F	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	195	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACAGGGTCGGGAAGTAATCCT	0.572000												
RPS6KC1	26750	broad.mit.edu	37	1	213349743	213349743	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr1:213349743C>T	uc010ptr.1	+	8	1111	c.952C>T	c.(952-954)CCT>TCT	p.P318S	RPS6KC1_uc001hkd.2_Missense_Mutation_p.P306S|RPS6KC1_uc010pts.1_Intron|RPS6KC1_uc010ptt.1_Intron|RPS6KC1_uc010ptu.1_Missense_Mutation_p.P137S|RPS6KC1_uc010ptv.1_5'UTR|RPS6KC1_uc001hke.2_Missense_Mutation_p.P137S	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	318					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CTTCCATTAGCCTCCAGGATC	0.473000												
AKR1C1	1645	broad.mit.edu	37	10	5008119	5008119	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:5008119A>C	uc001iho.2	+	7	939	c.98A>C	c.(97-99)AAA>ACA	p.K33T	AKR1E2_uc001ihl.1_Intron|AKR1C2_uc010qan.1_Intron|AKR1C3_uc001ihr.2_Missense_Mutation_p.K33T|AKR1C1_uc009xhx.2_Missense_Mutation_p.K33T|AKR1C1_uc001ihq.2_Missense_Mutation_p.K33T	NM_001353	NP_001344	Q04828	AK1C1_HUMAN	aldo-keto reductase family 1, member C1	33					bile acid and bile salt transport|bile acid metabolic process|cholesterol homeostasis|intestinal cholesterol absorption|protein homooligomerization|response to organophosphorus|xenobiotic metabolic process	cytosol	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid binding|indanol dehydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			ovary(2)	2					NADH(DB00157)	CCTAAAAGTAAAGCTTTAGAG	0.443000												
RPP38	10557	broad.mit.edu	37	10	15146039	15146039	+	Silent	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:15146039T>G	uc001iny.3	+	3	1439	c.726T>G	c.(724-726)CCT>CCG	p.P242P	RPP38_uc009xjm.2_Silent_p.P242P|RPP38_uc001inx.3_Silent_p.P242P	NM_183005	NP_892117	P78345	RPP38_HUMAN	ribonuclease P/MRP 38 subunit	242					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			ovary(1)	1						TGTCAAAACCTAAGAGAAAGC	0.403000												
PLXDC2	84898	broad.mit.edu	37	10	20465942	20465942	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:20465942A>C	uc001iqg.1	+	8	1535	c.898A>C	c.(898-900)ACA>CCA	p.T300P	PLXDC2_uc001iqh.1_Missense_Mutation_p.T251P|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	300	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TCGAAGAAGAACAATTTATGA	0.323000												
MYO3A	53904	broad.mit.edu	37	10	26462823	26462823	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:26462823A>C	uc001isn.2	+	30	3990	c.3630A>C	c.(3628-3630)GAA>GAC	p.E1210D	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1210					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TAGGGCCAGAAGTAAGCCCCA	0.413000												
ZEB1	6935	broad.mit.edu	37	10	31810825	31810825	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:31810825A>C	uc001ivs.3	+	7	2625	c.2562A>C	c.(2560-2562)CAA>CAC	p.Q854H	ZEB1_uc001ivr.3_Missense_Mutation_p.Q636H|ZEB1_uc010qee.1_Missense_Mutation_p.Q636H|ZEB1_uc010qef.1_Missense_Mutation_p.Q636H|ZEB1_uc009xlj.1_Missense_Mutation_p.Q780H|ZEB1_uc010qeg.1_Missense_Mutation_p.Q713H|ZEB1_uc009xlk.1_Missense_Mutation_p.Q636H|ZEB1_uc001ivt.3_Missense_Mutation_p.Q636H|ZEB1_uc001ivu.3_Missense_Mutation_p.Q855H|ZEB1_uc001ivv.3_Missense_Mutation_p.Q834H|ZEB1_uc010qeh.1_Missense_Mutation_p.Q787H|ZEB1_uc009xlo.1_Missense_Mutation_p.Q837H|ZEB1_uc009xlp.2_Missense_Mutation_p.Q838H	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	854					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				CTGCAGTCCAAGAACCACCCT	0.438000												
SLIT1	6585	broad.mit.edu	37	10	98773796	98773796	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:98773796T>C	uc001kmw.2	-	29	3341	c.3089A>G	c.(3088-3090)CAG>CGG	p.Q1030R		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1030	EGF-like 3.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CAGGGGGCACTGGCAGGTGTA	0.602000												
SEC31B	25956	broad.mit.edu	37	10	102257863	102257863	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:102257863C>A	uc001krc.1	-	15	1888	c.1786G>T	c.(1786-1788)GCC>TCC	p.A596S	SEC31B_uc010qpo.1_Missense_Mutation_p.A595S|SEC31B_uc001krd.1_Missense_Mutation_p.A133S|SEC31B_uc001krf.1_Missense_Mutation_p.A133S|SEC31B_uc001kre.1_Missense_Mutation_p.A133S|SEC31B_uc001krg.1_Missense_Mutation_p.A165S	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	596					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CCAGCCTGGGCCAGGATAATG	0.552000												
C10orf118	55088	broad.mit.edu	37	10	115910947	115910947	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:115910947T>G	uc001lbb.1	-	4	1444	c.792A>C	c.(790-792)GAA>GAC	p.E264D	C10orf118_uc001lbc.1_Missense_Mutation_p.E264D|C10orf118_uc009xye.1_RNA	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	264	Potential.									ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		AAGCTTTAACTTCTTTATTAA	0.328000												
PRLHR	2834	broad.mit.edu	37	10	120354492	120354492	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr10:120354492G>A	uc001ldp.1	-	2	404	c.265C>T	c.(265-267)CGC>TGC	p.R89C		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	89	Cytoplasmic (Potential).			R -> P (in Ref. 1; AAC50504).	female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		TGCAGCCGGCGCACCCGCGCG	0.652000												
TRIM5	85363	broad.mit.edu	37	11	5700392	5700392	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:5700392A>T	uc001mbm.1	-	3	682	c.425T>A	c.(424-426)CTC>CAC	p.L142H	TRIM5_uc001mbq.1_Missense_Mutation_p.L142H|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Missense_Mutation_p.L142H|TRIM5_uc001mbo.2_Missense_Mutation_p.L142H|TRIM5_uc001mbp.2_Missense_Mutation_p.L142H	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	142	Potential.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		AGCTGCCTGGAGCTTCACCTG	0.453000												
RAG2	5897	broad.mit.edu	37	11	36614484	36614484	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:36614484T>C	uc001mwv.3	-	2	1423	c.1235A>G	c.(1234-1236)GAG>GGG	p.E412G	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	412					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				GTAGCCTGTCTCAGACTCATC	0.403000									Familial_Hemophagocytic_Lymphohistiocytosis			
OR4C12	283093	broad.mit.edu	37	11	50003180	50003180	+	Silent	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:50003180T>C	uc010ria.1	-	1	858	c.858A>G	c.(856-858)ACA>ACG	p.T286T		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CATTTCTGAGTGTGTAGACCA	0.388000												
OR5L2	26338	broad.mit.edu	37	11	55595336	55595336	+	Silent	SNP	C	C	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:55595336C>A	uc001nhy.1	+	1	642	c.642C>A	c.(640-642)ATC>ATA	p.I214I		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TCATGATCATCCTCACCTCCT	0.502000										HNSCC(27;0.073)		
OR10AG1	282770	broad.mit.edu	37	11	55735873	55735873	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:55735873A>C	uc010rit.1	-	1	67	c.67T>G	c.(67-69)TTA>GTA	p.L23V		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	23	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					TACATAAGTAAAAATATACTA	0.323000												
OR5M8	219484	broad.mit.edu	37	11	56258416	56258416	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:56258416A>G	uc001nix.1	-	1	431	c.431T>C	c.(430-432)ATC>ACC	p.I144T		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					AGGCACCGTGATGAGGAAGGA	0.512000												
SLC43A3	29015	broad.mit.edu	37	11	57193027	57193027	+	Missense_Mutation	SNP	G	G	A	rs140882001		TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:57193027G>A	uc001nkg.2	-	4	711	c.301C>T	c.(301-303)CGC>TGC	p.R101C	PRG2_uc001nke.2_5'Flank|SLC43A3_uc001nkh.2_Missense_Mutation_p.R101C|SLC43A3_uc010rjr.1_Missense_Mutation_p.R114C|SLC43A3_uc009yme.2_Missense_Mutation_p.R101C|SLC43A3_uc001nki.2_Missense_Mutation_p.R101C|SLC43A3_uc009ymf.1_Missense_Mutation_p.R101C|SLC43A3_uc010rjs.1_Missense_Mutation_p.R101C|SLC43A3_uc009ymg.1_Missense_Mutation_p.R114C	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	101					transmembrane transport	integral to membrane				central_nervous_system(1)	1						GCTATGAGGCGTGCCACGGTG	0.527000												
ARHGEF17	9828	broad.mit.edu	37	11	73022184	73022184	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:73022184G>A	uc001otu.2	+	1	2522	c.2501G>A	c.(2500-2502)CGT>CAT	p.R834H		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	834					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CCCAGCCGCCGTGGGGAGCTG	0.642000												
GRM5	2915	broad.mit.edu	37	11	88241767	88241767	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr11:88241767G>A	uc001pcq.2	-	9	3832	c.3632C>T	c.(3631-3633)TCG>TTG	p.S1211L	GRM5_uc009yvm.2_Missense_Mutation_p.S1179L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	1211	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CATTCACAACGACGAGGAGCT	0.577000												
A2ML1	144568	broad.mit.edu	37	12	9020616	9020616	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:9020616C>T	uc001quz.3	+	30	3994	c.3896C>T	c.(3895-3897)ACG>ATG	p.T1299M	A2ML1_uc001qva.1_Missense_Mutation_p.T879M|A2ML1_uc010sgm.1_Missense_Mutation_p.T799M|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1143						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGAATGTACACGTTGGAGGCC	0.493000												
C12orf63	374467	broad.mit.edu	37	12	97158901	97158901	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:97158901A>C	uc001tet.1	+	27	3539	c.3461A>C	c.(3460-3462)AAT>ACT	p.N1154T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1154										skin(6)|ovary(1)	7						GGAAAGAAGAATACTAGAATG	0.318000												
ANO4	121601	broad.mit.edu	37	12	101477501	101477501	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:101477501C>T	uc010svm.1	+	16	2013	c.1441C>T	c.(1441-1443)CGG>TGG	p.R481W	ANO4_uc001thw.2_Missense_Mutation_p.R446W|ANO4_uc001thx.2_Missense_Mutation_p.R481W|ANO4_uc001thy.2_Intron	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	481	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CAAGAAAGAGCGGATGAATCC	0.378000										HNSCC(74;0.22)		
FBXO21	23014	broad.mit.edu	37	12	117593659	117593659	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:117593659C>T	uc001twk.2	-	11	1672	c.1633G>A	c.(1633-1635)GGC>AGC	p.G545S	FBXO21_uc001twj.2_Missense_Mutation_p.G538S|FBXO21_uc009zwq.2_Missense_Mutation_p.G478S|FBXO21_uc001twl.1_Missense_Mutation_p.G158S	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	545					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TGGTGGTGGCCGTGCGGCAGG	0.607000											OREG0022166	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
RIMBP2	23504	broad.mit.edu	37	12	130884319	130884319	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:130884319A>C	uc001uil.2	-	18	3201	c.3037T>G	c.(3037-3039)TTC>GTC	p.F1013V		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	1013	SH3 3.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCTTCCAAGAAGTTTGAGGGC	0.463000												
RIMBP2	23504	broad.mit.edu	37	12	130935764	130935764	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:130935764G>A	uc001uil.2	-	5	593	c.429C>T	c.(427-429)AGC>AGT	p.S143S	RIMBP2_uc001uim.2_Silent_p.S51S	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	143						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGCATCTTGCGCTACCGGATC	0.637000												
GALNT9	50614	broad.mit.edu	37	12	132688116	132688116	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:132688116G>A	uc001ukc.3	-	7	1313	c.1197C>T	c.(1195-1197)CGC>CGT	p.R399R	GALNT9_uc009zyr.2_Silent_p.R173R|GALNT9_uc001ukb.2_Silent_p.R256R|GALNT9_uc001uka.2_Silent_p.R33R	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	399	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		CCTCGGCGGCGCGCAGGGCGT	0.642000												
RNF6	6049	broad.mit.edu	37	13	26788949	26788949	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr13:26788949C>T	uc001uqo.2	-	5	1361	c.1070G>A	c.(1069-1071)CGA>CAA	p.R357Q	RNF6_uc001uqn.1_Intron|RNF6_uc010aak.2_Missense_Mutation_p.R357Q|RNF6_uc001uqp.2_Missense_Mutation_p.R357Q|RNF6_uc001uqq.2_Missense_Mutation_p.R357Q|RNF6_uc010tdk.1_Intron	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	357	Arg-rich.				negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		TCTGCGTTCTCGTTCTCTATC	0.428000												
DCLK1	9201	broad.mit.edu	37	13	36699995	36699995	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr13:36699995T>G	uc001uvf.2	-	2	513	c.280A>C	c.(280-282)ACT>CCT	p.T94P		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	94	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TCCGACAGAGTTCGGGTCAAA	0.498000												
PCDH17	27253	broad.mit.edu	37	13	58208321	58208321	+	Silent	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr13:58208321T>C	uc001vhq.1	+	1	2533	c.1641T>C	c.(1639-1641)GCT>GCC	p.A547A	PCDH17_uc010aec.1_Silent_p.A547A	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	547	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGACCAAGGCTTTTGAGTTCA	0.582000												
RNF113B	140432	broad.mit.edu	37	13	98828825	98828825	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr13:98828825G>A	uc001vnk.2	-	1	697	c.666C>T	c.(664-666)CTC>CTT	p.L222L	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	222							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			TCTCCCACCCGAGCTTGTAAT	0.532000												
NALCN	259232	broad.mit.edu	37	13	101756694	101756694	+	Silent	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr13:101756694A>G	uc001vox.1	-	25	3030	c.2841T>C	c.(2839-2841)ACT>ACC	p.T947T		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	947	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGATGACAGCAGTTGGAGTGA	0.358000												
MYO16	23026	broad.mit.edu	37	13	109704747	109704747	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr13:109704747A>C	uc001vqt.1	+	25	3032	c.2906A>C	c.(2905-2907)AAG>ACG	p.K969T	MYO16_uc010agk.1_Missense_Mutation_p.K991T|MYO16_uc001vqu.1_Missense_Mutation_p.K769T|MYO16_uc010tjh.1_Missense_Mutation_p.K481T	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	969	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CGAGGACATAAGTCTGCCCTG	0.368000												
LRFN5	145581	broad.mit.edu	37	14	42356155	42356155	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr14:42356155C>A	uc001wvm.2	+	3	1525	c.327C>A	c.(325-327)AAC>AAA	p.N109K	LRFN5_uc010ana.2_Missense_Mutation_p.N109K	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	109	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGAATAGCAACAGATTGACTA	0.373000										HNSCC(30;0.082)		
DIO2	1734	broad.mit.edu	37	14	80669227	80669227	+	Silent	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr14:80669227T>G	uc010tvq.1	-	4	1029	c.627A>C	c.(625-627)CGA>CGC	p.R209R	DIO2_uc010tvp.1_Silent_p.R245R|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Silent_p.R209R|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	209					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		CAGCCACAACTCGGCACTGGG	0.527000											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
SERPINA9	327657	broad.mit.edu	37	14	94936126	94936126	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr14:94936126T>C	uc001ydf.2	-	2	267	c.106A>G	c.(106-108)ATC>GTC	p.I36V	SERPINA9_uc001yde.2_Missense_Mutation_p.I36V|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Intron|SERPINA9_uc001ydh.1_Missense_Mutation_p.I36V|SERPINA9_uc001ydi.1_Intron	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	18					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		ACACAGTAGATTGGAGCACAG	0.512000												
C15orf2	23742	broad.mit.edu	37	15	24923084	24923084	+	Silent	SNP	A	A	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr15:24923084A>T	uc001ywo.2	+	1	2544	c.2070A>T	c.(2068-2070)TCA>TCT	p.S690S		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	690					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CAGCATCATCATCCAAACCTC	0.493000												
SRRM2	23524	broad.mit.edu	37	16	2813747	2813747	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr16:2813747G>A	uc002crk.2	+	11	3767	c.3218G>A	c.(3217-3219)AGT>AAT	p.S1073N	SRRM2_uc002crj.1_Missense_Mutation_p.S977N|SRRM2_uc002crl.1_Missense_Mutation_p.S1073N|SRRM2_uc010bsu.1_Missense_Mutation_p.S977N	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1073	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GATACTTCAAGTCCAGAAGTG	0.463000												
TAOK2	9344	broad.mit.edu	37	16	29996795	29996795	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr16:29996795C>T	uc002dva.1	+	14	2467	c.1684C>T	c.(1684-1686)CGG>TGG	p.R562W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.R562W|TAOK2_uc002dvc.1_Missense_Mutation_p.R562W|TAOK2_uc010bzm.1_Missense_Mutation_p.R569W|TAOK2_uc002dvd.1_Missense_Mutation_p.R389W	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	562					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GGCCGAGGAGCGGAAGTTCCA	0.632000												
MNT	4335	broad.mit.edu	37	17	2298250	2298250	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr17:2298250G>A	uc002fur.2	-	2	824	c.572C>T	c.(571-573)CCG>CTG	p.P191L		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	191					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		GGGTGGGGGCGGCTGCTGGGG	0.667000												
OR1A1	8383	broad.mit.edu	37	17	3119769	3119769	+	Silent	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr17:3119769T>G	uc010vrc.1	+	1	855	c.855T>G	c.(853-855)CCT>CCG	p.P285P		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGTTAAATCCTTTCATCTACA	0.463000												
MFSD6L	162387	broad.mit.edu	37	17	8700939	8700939	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr17:8700939G>A	uc002glp.1	-	1	1648	c.1500C>T	c.(1498-1500)TAC>TAT	p.Y500Y		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	500	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						AGCCACTCCCGTAAAAGTGGC	0.627000												
CASC3	22794	broad.mit.edu	37	17	38323766	38323766	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr17:38323766C>T	uc010cwt.1	+	9	1847	c.1552C>T	c.(1552-1554)CGA>TGA	p.R518*	CASC3_uc002hue.2_Nonsense_Mutation_p.R518*	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	518	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						CCAGGGTGGTCGAGCCAAACG	0.498000												
FAM104A	84923	broad.mit.edu	37	17	71223362	71223362	+	Missense_Mutation	SNP	G	G	A	rs145613050		TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr17:71223362G>A	uc002jji.3	-	2	351	c.263C>T	c.(262-264)CCC>CTC	p.P88L	FAM104A_uc002jjj.3_Missense_Mutation_p.P88L	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	88											0			LUSC - Lung squamous cell carcinoma(166;0.197)			GGTCTGGGGGGGAAGATGGTT	0.428000												
ARMC7	79637	broad.mit.edu	37	17	73124926	73124926	+	Silent	SNP	C	C	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr17:73124926C>G	uc002jmw.1	+	3	692	c.390C>G	c.(388-390)CGC>CGG	p.R130R	ARMC7_uc010wru.1_3'UTR|ARMC7_uc010dga.1_RNA	NM_024585	NP_078861	Q9H6L4	ARMC7_HUMAN	armadillo repeat containing 7	130	ARM 2.						binding			pancreas(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			CGCCGGGCCGCAGCTTTCTCC	0.642000												
RNF213	57674	broad.mit.edu	37	17	78348265	78348265	+	Missense_Mutation	SNP	G	G	A	rs61743307	byFrequency	TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr17:78348265G>A	uc002jyh.1	+	25	7392	c.7169G>A	c.(7168-7170)CGG>CAG	p.R2390Q	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.R772Q	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CAGGGGCTGCGGCAGGACCAC	0.547000												
LAMA1	284217	broad.mit.edu	37	18	6958572	6958572	+	Missense_Mutation	SNP	A	A	G	rs140908333		TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr18:6958572A>G	uc002knm.2	-	55	7962	c.7868T>C	c.(7867-7869)CTG>CCG	p.L2623P	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Missense_Mutation_p.L76P|LAMA1_uc010wzj.1_Missense_Mutation_p.L2099P	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2623	Laminin G-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCGACGTACAGATTGGACAC	0.433000												
SYT4	6860	broad.mit.edu	37	18	40851687	40851687	+	Silent	SNP	G	G	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr18:40851687G>C	uc002law.2	-	3	1329	c.960C>G	c.(958-960)TCC>TCG	p.S320S	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Silent_p.S302S|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	320	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CTGAAAGTCCGGACACATCAG	0.418000												
ZSWIM4	65249	broad.mit.edu	37	19	13936482	13936482	+	Silent	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr19:13936482A>G	uc002mxh.1	+	11	2172	c.1983A>G	c.(1981-1983)CCA>CCG	p.P661P	ZSWIM4_uc010xng.1_Silent_p.P584P	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	661							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TCAGCGCCCCACCAGACACCA	0.672000												
ZNF675	171392	broad.mit.edu	37	19	23836911	23836911	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr19:23836911T>G	uc002nri.2	-	4	1006	c.824A>C	c.(823-825)AAG>ACG	p.K275T		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	275	C2H2-type 5.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ATGAATTATCTTATGTGTAGT	0.348000												
GRAMD1A	57655	broad.mit.edu	37	19	35502408	35502408	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr19:35502408C>T	uc010xse.1	+	7	693	c.556C>T	c.(556-558)CGC>TGC	p.R186C	GRAMD1A_uc002nxi.1_Missense_Mutation_p.R273C|GRAMD1A_uc002nxk.2_Missense_Mutation_p.R179C|GRAMD1A_uc002nxl.2_5'UTR|GRAMD1A_uc010xsf.1_Missense_Mutation_p.R191C|GRAMD1A_uc002nxm.1_5'Flank	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	186						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCCCGTGACCGCTGCTTCCT	0.622000												
ZNF667	63934	broad.mit.edu	37	19	56954050	56954050	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr19:56954050T>C	uc002qnd.2	-	5	476	c.314A>G	c.(313-315)CAA>CGA	p.Q105R	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Missense_Mutation_p.Q105R|ZNF667_uc010etm.2_Missense_Mutation_p.Q48R	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GCAGATGCTTTGCCCAGATTT	0.398000												
ZNF274	10782	broad.mit.edu	37	19	58723899	58723899	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr19:58723899G>A	uc002qrq.1	+	10	1811	c.1352G>A	c.(1351-1353)CGC>CAC	p.R451H	ZNF274_uc002qrr.1_Missense_Mutation_p.R419H|ZNF274_uc002qrs.1_Missense_Mutation_p.R346H|ZNF274_uc010eum.1_Missense_Mutation_p.R210H	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	451					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		AAACGATTGCGCAAACGTGAC	0.428000												
TAF1B	9014	broad.mit.edu	37	2	10015998	10015998	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr2:10015998G>A	uc002qzz.2	+	7	658	c.558G>A	c.(556-558)ACG>ACA	p.T186T	TAF1B_uc010exc.2_Silent_p.T186T|TAF1B_uc002qzy.3_Silent_p.T186T|TAF1B_uc010yja.1_Intron|TAF1B_uc010exd.2_Intron	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	186					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCTAAGAAACGTCTGTCTGCT	0.363000												
EGR4	1961	broad.mit.edu	37	2	73518869	73518869	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr2:73518869G>A	uc010yrj.1	-	2	1561	c.1486C>T	c.(1486-1488)CGC>TGC	p.R496C	EGR4_uc010yrk.1_Missense_Mutation_p.R495C	NM_001965	NP_001956	Q05215	EGR4_HUMAN	early growth response 4	392						intracellular	nucleic acid binding|zinc ion binding				0						TCGTCGGAGCGCGCAAAGCTC	0.687000												
STAMBP	10617	broad.mit.edu	37	2	74077571	74077571	+	Silent	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr2:74077571C>T	uc002sjs.2	+	7	986	c.936C>T	c.(934-936)AAC>AAT	p.N312N	STAMBP_uc002sjt.2_Silent_p.N312N|STAMBP_uc002sju.2_Silent_p.N312N|STAMBP_uc002sjv.2_Silent_p.N312N	NM_201647	NP_964010	O95630	STABP_HUMAN	STAM binding protein	312	MPN.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			ovary(1)|lung(1)|breast(1)|pancreas(1)	4						ATTACTGCAACACAGAGAACG	0.458000												
CNTNAP5	129684	broad.mit.edu	37	2	125660638	125660638	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr2:125660638T>C	uc002tno.2	+	22	3977	c.3613T>C	c.(3613-3615)TCA>CCA	p.S1205P	CNTNAP5_uc010flu.2_Missense_Mutation_p.S1206P	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1205	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CATGGTGGACTCAGATGTGAA	0.532000												
STAM2	10254	broad.mit.edu	37	2	153001434	153001434	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr2:153001434T>C	uc002tyc.3	-	6	835	c.485A>G	c.(484-486)AAC>AGC	p.N162S	STAM2_uc010foa.1_Missense_Mutation_p.N162S|STAM2_uc002tyd.2_Missense_Mutation_p.N162S	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	162					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		TTTGTTTTTGTTCGATGACGT	0.318000												
TTN	7273	broad.mit.edu	37	2	179583304	179583304	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr2:179583304A>C	uc010zfg.1	-	82	21021	c.20797T>G	c.(20797-20799)TTG>GTG	p.L6933V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L3594V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7860							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAATCAGCCAATCTTTTCACA	0.403000												
ZNF804A	91752	broad.mit.edu	37	2	185803464	185803464	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr2:185803464C>T	uc002uph.2	+	4	3935	c.3341C>T	c.(3340-3342)GCT>GTT	p.A1114V		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1114						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						gcagctgcagctgcagccgca	0.348000												
CLDN17	26285	broad.mit.edu	37	21	31538305	31538305	+	Silent	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr21:31538305T>G	uc011acv.1	-	1	631	c.631A>C	c.(631-633)AGA>CGA	p.R211R		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	211	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						GTCGTATTTCTTCGCTTATCT	0.458000												
MTP18	51537	broad.mit.edu	37	22	30823179	30823179	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr22:30823179C>T	uc003ahw.1	+	3	365	c.217C>T	c.(217-219)CGC>TGC	p.R73C	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Missense_Mutation_p.R235C|MTP18_uc010gvy.1_Intron|MTP18_uc003ahx.1_Intron	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	73					apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						TGAAGCAGGCCGCAGCGCCAG	0.632000												
SYN3	8224	broad.mit.edu	37	22	33265093	33265093	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr22:33265093A>G	uc003amx.2	-	4	640	c.481T>C	c.(481-483)TTC>CTC	p.F161L	SYN3_uc003amy.2_Missense_Mutation_p.F161L|SYN3_uc003amz.2_Missense_Mutation_p.F160L	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	161	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						ACCAGGATGAAGTCTGGCTTG	0.582000												
FBLN2	2199	broad.mit.edu	37	3	13678019	13678019	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr3:13678019C>T	uc011avb.1	+	16	3273	c.3148C>T	c.(3148-3150)CGC>TGC	p.R1050C	FBLN2_uc011auz.1_Missense_Mutation_p.R1076C|FBLN2_uc011ava.1_Missense_Mutation_p.R1097C|FBLN2_uc011avc.1_Missense_Mutation_p.R1097C	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	1050	EGF-like 10; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GGGTAGCTTCCGCTGCCTGCG	0.602000												
KCNMB2	10242	broad.mit.edu	37	3	178560673	178560673	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr3:178560673T>C	uc003fjd.2	+	5	999	c.656T>C	c.(655-657)CTT>CCT	p.L219P	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Missense_Mutation_p.L219P|KCNMB2_uc003fjf.2_Missense_Mutation_p.L219P|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_RNA	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	219	Cytoplasmic (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			ATGGTGAAACTTACACAGTAC	0.398000												
KIAA1530	57654	broad.mit.edu	37	4	1377628	1377628	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr4:1377628G>A	uc003gde.3	+	13	2383	c.1936G>A	c.(1936-1938)GGG>AGG	p.G646R	KIAA1530_uc010ibv.2_Missense_Mutation_p.G197R	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	646											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			CAGGTACAGCGGGAAAGGCAG	0.572000												
KLB	152831	broad.mit.edu	37	4	39439478	39439478	+	Missense_Mutation	SNP	C	C	T	rs138571801		TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr4:39439478C>T	uc003gua.2	+	3	1565	c.1468C>T	c.(1468-1470)CGG>TGG	p.R490W	KLB_uc011byj.1_Missense_Mutation_p.R490W	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	490	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						ACAGAAAGAGCGGAAACCTAA	0.438000												
UNC5C	8633	broad.mit.edu	37	4	96163619	96163619	+	Silent	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr4:96163619A>G	uc003htp.1	-	7	1223	c.1069T>C	c.(1069-1071)TTG>CTG	p.L357L	UNC5C_uc010ilc.1_Silent_p.L357L|UNC5C_uc003htq.2_Silent_p.L357L	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	357	Extracellular (Potential).|TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTGGATTGCAAGACGAGGCCG	0.542000												
NPY2R	4887	broad.mit.edu	37	4	156136124	156136124	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr4:156136124C>T	uc003ioq.2	+	2	1528	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	NPY2R_uc003ior.2_Missense_Mutation_p.R345W	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	345	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CTGTGAGCAGCGGTTGGATGC	0.517000												
TMEM144	55314	broad.mit.edu	37	4	159136418	159136418	+	Missense_Mutation	SNP	C	C	G	rs11556229		TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr4:159136418C>G	uc003ipx.2	+	4	705	c.185C>G	c.(184-186)CCA>CGA	p.P62R	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	62						integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		TTACATTGTCCAAAGTTTTGG	0.358000												
ADAMTS16	170690	broad.mit.edu	37	5	5239960	5239960	+	Silent	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr5:5239960T>G	uc003jdl.2	+	16	2583	c.2445T>G	c.(2443-2445)ACT>ACG	p.T815T	ADAMTS16_uc003jdk.1_Silent_p.T815T	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	815	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CGGGCACTACTTTCGACTACA	0.512000												
ADCY2	108	broad.mit.edu	37	5	7804726	7804726	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr5:7804726T>G	uc003jdz.1	+	22	2871	c.2804T>G	c.(2803-2805)GTT>GGT	p.V935G	ADCY2_uc011cmo.1_Missense_Mutation_p.V755G|ADCY2_uc010itm.1_Missense_Mutation_p.V131G	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	935	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TTCAGTGGAGTTGAAAAGATT	0.493000												
PCDHB8	56128	broad.mit.edu	37	5	140558400	140558400	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr5:140558400T>C	uc011dai.1	+	1	971	c.785T>C	c.(784-786)GTT>GCT	p.V262A	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	262	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCTTCCTGGTTGTGAAGGTC	0.438000												
HIST1H1D	3007	broad.mit.edu	37	6	26234540	26234540	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:26234540G>C	uc003nhd.2	-	1	677	c.622C>G	c.(622-624)CCG>GCG	p.P208A		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	208					nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GTAACCTTCGGCTTCCCCGAC	0.507000												
CUL7	9820	broad.mit.edu	37	6	43019974	43019974	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:43019974T>G	uc003otq.2	-	2	856	c.553A>C	c.(553-555)ATA>CTA	p.I185L	CUL7_uc011dvb.1_Missense_Mutation_p.I237L|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	185					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGGGCTTGTATCATCCGGCCT	0.577000												
CUL7	9820	broad.mit.edu	37	6	43020260	43020260	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:43020260G>A	uc003otq.2	-	2	570	c.267C>T	c.(265-267)ATC>ATT	p.I89I	CUL7_uc011dvb.1_Silent_p.I141I|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	89					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGGAGGGCCCGATGACCTGGC	0.587000												
HS3ST5	222537	broad.mit.edu	37	6	114378466	114378466	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:114378466A>T	uc003pwg.3	-	2	1028	c.996T>A	c.(994-996)AAT>AAA	p.N332K	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.N332K	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	332	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		AAAATTTTTGATTAAAAGGAT	0.428000												
EYA4	2070	broad.mit.edu	37	6	133783490	133783490	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:133783490T>C	uc003qec.3	+	8	913	c.455T>C	c.(454-456)CTT>CCT	p.L152P	EYA4_uc011ecq.1_Missense_Mutation_p.L98P|EYA4_uc011ecr.1_Missense_Mutation_p.L98P|EYA4_uc003qed.3_Missense_Mutation_p.L152P|EYA4_uc003qee.3_Missense_Mutation_p.L129P|EYA4_uc011ecs.1_Missense_Mutation_p.L152P|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	152			L -> R (in a colorectal cancer sample; somatic mutation).		anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity	p.L152R(1)		large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CCACACATTCTTTCTACACCA	0.448000												
TNFAIP3	7128	broad.mit.edu	37	6	138196897	138196897	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:138196897C>T	uc003qhr.2	+	4	625	c.559C>T	c.(559-561)CAG>TAG	p.Q187*	TNFAIP3_uc003qhs.2_Nonsense_Mutation_p.Q187*	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	187	TRAF-binding.|OTU.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		AAGTGGACTTCAGTACAACTC	0.453000			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma							
AKAP12	9590	broad.mit.edu	37	6	151672610	151672610	+	Silent	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:151672610C>T	uc011eep.1	+	4	3324	c.3084C>T	c.(3082-3084)GGC>GGT	p.G1028G	AKAP12_uc003qoe.2_Silent_p.G1028G|AKAP12_uc003qof.2_Silent_p.G930G|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.G923G	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1028					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TGGAAGGTGGCGTACCTGACA	0.582000												
SYNE1	23345	broad.mit.edu	37	6	152737734	152737734	+	Silent	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:152737734A>C	uc010kiw.2	-	41	6440	c.5838T>G	c.(5836-5838)ACT>ACG	p.T1946T	SYNE1_uc003qot.3_Silent_p.T1953T|SYNE1_uc003qou.3_Silent_p.T1946T|SYNE1_uc010kjb.1_Silent_p.T1929T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1946	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTGCAGGAAGTCCTTTGCT	0.502000										HNSCC(10;0.0054)		
SYNE1	23345	broad.mit.edu	37	6	152782807	152782807	+	Silent	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:152782807A>G	uc010kiw.2	-	21	2921	c.2319T>C	c.(2317-2319)ATT>ATC	p.I773I	SYNE1_uc003qot.3_Silent_p.I780I|SYNE1_uc003qou.3_Silent_p.I773I|SYNE1_uc010kjb.1_Silent_p.I756I|SYNE1_uc003qow.2_Silent_p.I68I|SYNE1_uc003qox.1_Silent_p.I289I|SYNE1_uc003qoz.2_Silent_p.I205I|SYNE1_uc003qoy.2_Silent_p.I340I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	773	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTCTTTGGTAATGAGGTGTG	0.408000										HNSCC(10;0.0054)		
LPA	4018	broad.mit.edu	37	6	160963737	160963737	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr6:160963737T>G	uc003qtl.2	-	35	5622	c.5502A>C	c.(5500-5502)CAA>CAC	p.Q1834H		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4342	Peptidase S1.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGAGACTGACTTGCCAGGGCC	0.507000												
DNAH11	8701	broad.mit.edu	37	7	21639582	21639582	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:21639582A>T	uc003svc.2	+	15	2876	c.2845A>T	c.(2845-2847)ATC>TTC	p.I949F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	949	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGCACAAATGATCTTGTTGCC	0.403000									Kartagener_syndrome			
DNAH11	8701	broad.mit.edu	37	7	21658722	21658722	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:21658722A>C	uc003svc.2	+	24	4305	c.4274A>C	c.(4273-4275)AAG>ACG	p.K1425T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1425	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AATCAGGTCAAGTTTTTAATA	0.383000									Kartagener_syndrome			
GLI3	2737	broad.mit.edu	37	7	42005807	42005807	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:42005807G>A	uc011kbh.1	-	15	2955	c.2864C>T	c.(2863-2865)ACG>ATG	p.T955M	GLI3_uc011kbg.1_Missense_Mutation_p.T896M	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	955					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CGCCAGGCGCGTCTTCAGGCT	0.721000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
NPC1L1	29881	broad.mit.edu	37	7	44579660	44579660	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:44579660G>A	uc003tlb.2	-	2	392	c.336C>T	c.(334-336)CGC>CGT	p.R112R	NPC1L1_uc003tlc.2_Silent_p.R112R|NPC1L1_uc011kbw.1_Silent_p.R112R|NPC1L1_uc003tld.2_Silent_p.R112R	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	112	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AGGCTGGGCAGCGGGTGAGGA	0.612000												
PCLO	27445	broad.mit.edu	37	7	82544222	82544222	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:82544222T>G	uc003uhx.2	-	7	13369	c.13080A>C	c.(13078-13080)GAA>GAC	p.E4360D	PCLO_uc003uhv.2_Missense_Mutation_p.E4360D|PCLO_uc010lec.2_Missense_Mutation_p.E1325D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4291					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTGGGCTTTCTTCTTCAGAAT	0.507000												
FZD1	8321	broad.mit.edu	37	7	90896057	90896057	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:90896057T>A	uc003ula.2	+	1	2275	c.1862T>A	c.(1861-1863)ATC>AAC	p.I621N		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	621	Helical; Name=7; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GGCTTCTGGATCTGGTCCGGC	0.602000												
TFEC	22797	broad.mit.edu	37	7	115580853	115580853	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:115580853T>C	uc003vhj.1	-	8	980	c.796A>G	c.(796-798)ACT>GCT	p.T266A	TFEC_uc003vhk.1_Missense_Mutation_p.T237A|TFEC_uc003vhl.3_3'UTR|TFEC_uc011kmw.1_3'UTR	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	266						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			TGAGACACAGTCAGTTGTTGG	0.468000												
DGKI	9162	broad.mit.edu	37	7	137237206	137237206	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:137237206A>C	uc003vtt.2	-	20	2057	c.2056T>G	c.(2056-2058)TTG>GTG	p.L686V	DGKI_uc003vtu.2_Missense_Mutation_p.L386V	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	686					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GCTGGGGCCAACCTACAGGGC	0.517000												
WEE2	494551	broad.mit.edu	37	7	141424832	141424832	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr7:141424832C>T	uc003vwn.2	+	9	1634	c.1228C>T	c.(1228-1230)CGG>TGG	p.R410W	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	410	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GAAGGATTACCGGCACCTTCC	0.463000												
CYP7A1	1581	broad.mit.edu	37	8	59412593	59412593	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr8:59412593A>G	uc003xtm.3	-	1	128	c.65T>C	c.(64-66)CTT>CCT	p.L22P		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	22					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CCTAATTCCAAGAATAAGCCA	0.318000									Neonatal_Giant_Cell_Hepatitis			
RIMS2	9699	broad.mit.edu	37	8	104930678	104930678	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr8:104930678G>A	uc003yls.2	+	7	1621	c.1380G>A	c.(1378-1380)CCG>CCA	p.P460P	RIMS2_uc003ylp.2_Silent_p.P682P|RIMS2_uc003ylw.2_Silent_p.P490P|RIMS2_uc003ylq.2_Silent_p.P490P|RIMS2_uc003ylr.2_Silent_p.P537P|RIMS2_uc003ylt.2_Silent_p.P83P|RIMS2_uc003ylu.1_Silent_p.P73P|RIMS2_uc003ylv.1_Silent_p.P73P	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	760					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAGATATACCGCGAATACCTG	0.299000										HNSCC(12;0.0054)		
PAPPA	5069	broad.mit.edu	37	9	118950303	118950303	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr9:118950303A>G	uc004bjn.2	+	2	1667	c.1286A>G	c.(1285-1287)AAC>AGC	p.N429S	PAPPA_uc011lxp.1_Missense_Mutation_p.N222S|PAPPA_uc011lxq.1_Missense_Mutation_p.N222S	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	429	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CCCGAGTGCAACCACACGCTG	0.627000												
P2RY8	286530	broad.mit.edu	37	X	1584751	1584751	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:1584751C>T	uc004cpz.2	-	2	949	c.701G>A	c.(700-702)CGC>CAC	p.R234H		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	234	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCCCACCGCGCGCCTCCGCTG	0.657000			T	CRLF2	B-ALL|Downs associated ALL							
FANCB	2187	broad.mit.edu	37	X	14863287	14863287	+	Missense_Mutation	SNP	A	A	C	rs144205393	by1000genomes	TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:14863287A>C	uc004cwg.1	-	8	1886	c.1618T>G	c.(1618-1620)TTG>GTG	p.L540V	FANCB_uc004cwh.1_Missense_Mutation_p.L540V	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	540					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					CATGGCATCAAGTATGGTGCT	0.408000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia			
FAM47C	442444	broad.mit.edu	37	X	37027957	37027957	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:37027957G>A	uc004ddl.1	+	1	1488	c.1474G>A	c.(1474-1476)GAC>AAC	p.D492N		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	492										ovary(3)	3						AGAGCCTCCCGACACTGGAGT	0.622000												
USP9X	8239	broad.mit.edu	37	X	41002634	41002634	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:41002634C>T	uc004dfb.2	+	10	1885	c.1252C>T	c.(1252-1254)CGT>TGT	p.R418C	USP9X_uc004dfc.2_Missense_Mutation_p.R418C	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	418					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GAAGATTCTTCGTTTTGTCAT	0.348000												
ITM2A	9452	broad.mit.edu	37	X	78618190	78618190	+	Splice_Site	SNP	T	T	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:78618190T>A	uc004edh.2	-	4	777	c.442_splice	c.e4-1	p.G148_splice	ITM2A_uc011mqr.1_Splice_Site_p.G104_splice	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A							integral to membrane	protein binding			lung(2)	2						AGTCATTCCCTGTTAGGTAGG	0.413000												
CYLC1	1538	broad.mit.edu	37	X	83128538	83128538	+	Missense_Mutation	SNP	G	G	T	rs148140928		TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:83128538G>T	uc004eei.1	+	4	843	c.822G>T	c.(820-822)AAG>AAT	p.K274N	CYLC1_uc004eeh.1_Missense_Mutation_p.K273N	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	274					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						ATAATTCAAAGAATTATTCTT	0.318000												
H2BFWT	158983	broad.mit.edu	37	X	103267793	103267793	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:103267793G>A	uc004elr.2	-	1	464	c.440C>T	c.(439-441)CCG>CTG	p.P147L		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	147					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						CATCTGCCCCGGCAGCAGCAG	0.687000												
WDR44	54521	broad.mit.edu	37	X	117577561	117577561	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:117577561A>C	uc004eqn.2	+	18	2848	c.2423A>C	c.(2422-2424)AAG>ACG	p.K808T	WDR44_uc004eqo.2_Missense_Mutation_p.K800T|WDR44_uc011mtr.1_Missense_Mutation_p.K719T|WDR44_uc010nqi.2_Missense_Mutation_p.K518T	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	808	WD 6.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						TCAGAAGATAAGTATGTTTAT	0.358000												
KIAA1210	57481	broad.mit.edu	37	X	118222914	118222914	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:118222914T>G	uc004era.3	-	11	2279	c.2279A>C	c.(2278-2280)AAG>ACG	p.K760T		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	760										ovary(4)|skin(1)	5						AGGCAGAGTCTTGGCATAAAC	0.453000												
DCAF12L2	340578	broad.mit.edu	37	X	125298618	125298618	+	Silent	SNP	C	C	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:125298618C>T	uc004euk.1	-	1	1317	c.1290G>A	c.(1288-1290)GCG>GCA	p.A430A		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	430										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GGGTGTAGAGCGCATTGGGGA	0.597000												
GAB3	139716	broad.mit.edu	37	X	153924213	153924213	+	Silent	SNP	G	G	A			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chrX:153924213G>A	uc004fmj.1	-	8	1554	c.1506C>T	c.(1504-1506)GAC>GAT	p.D502D	GAB3_uc004fmk.1_Silent_p.D503D|GAB3_uc010nve.1_Silent_p.D503D|GAB3_uc004fml.1_Silent_p.D122D	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	502										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AGCTTTCTTCGTCTTCTCTGG	0.348000												
HNF1A	6927	broad.mit.edu	37	12	121438928	121438929	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D7-8579-01A-11D-2340-08	TCGA-D7-8579-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ec246de-8531-4ab1-8733-ae43cc85a8e6	34c5e3bc-b572-4b6e-9780-722172d7adc5	g.chr12:121438927_121438928C>CT	uc001tzg.3	+	9	1851_1852	c.1828_1829C>CT	c.(1828-1830)ctgfs	p.L610fs	HNF1A_uc010szn.2_Frame_Shift_Ins_p.L617fs|HNF1A_uc021rfa.1_Frame_Shift_Ins_p.L641fs|HNF1A_uc021rfb.1_Frame_Shift_Ins_p.L482fs|HNF1A_uc021rfc.1_Non-coding_Transcript	NM_000545	NP_000536	P20823	HNF1A_HUMAN	Homo sapiens HNF1 homeobox A (HNF1A), mRNA.	610					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCAGAGCCACCTGCTGCCATCC	0.624									Hepatic Adenoma, Familial Clustering of			
