Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
UBE2J2	118424	broad.mit.edu	37	1	1203290	1203290	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:1203290G>A	uc001adn.2	-	2	393	c.83C>T	c.(82-84)CCG>CTG	p.P28L	UBE2J2_uc001adm.2_5'UTR|UBE2J2_uc001ado.2_Missense_Mutation_p.P28L|UBE2J2_uc001adp.2_Missense_Mutation_p.P28L|UBE2J2_uc001adq.2_5'UTR|UBE2J2_uc001adr.2_Intron|UBE2J2_uc001ads.2_5'UTR	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	28	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		GTAAGGCACCGGGTCTTTCTT	0.582000												
PRAMEF20	645425	broad.mit.edu	37	1	13743092	13743092	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:13743092G>A	uc009voa.1	+	2	380	c.281G>A	c.(280-282)CGT>CAT	p.R94H		NM_001099852	NP_001093322	Q5VT98	PRA20_HUMAN	PRAME family member 20	94										ovary(1)	1	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.5e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000156)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACAGGGTTCGTCTCAGGTGA	0.607000												
UBR4	23352	broad.mit.edu	37	1	19451145	19451145	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:19451145G>C	uc001bbi.2	-	65	9482	c.9478C>G	c.(9478-9480)CTA>GTA	p.L3160V	UBR4_uc001bbk.1_Missense_Mutation_p.L807V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3160					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATTTCTGTTAGAAGCTGAGTA	0.428000												
ZBTB40	9923	broad.mit.edu	37	1	22837716	22837716	+	Silent	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:22837716G>C	uc001bft.2	+	11	2389	c.1878G>C	c.(1876-1878)CTG>CTC	p.L626L	ZBTB40_uc001bfu.2_Silent_p.L626L|ZBTB40_uc009vqi.1_Silent_p.L514L|ZBTB40_uc001bfv.1_Silent_p.L255L	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	626					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		AAGCTTCCCTGAGAGCAGTGC	0.507000												
HCRTR1	3061	broad.mit.edu	37	1	32085185	32085185	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:32085185C>A	uc009vtx.2	+	4	637	c.252C>A	c.(250-252)TTC>TTA	p.F84L	HCRTR1_uc001btb.2_Intron|HCRTR1_uc001btc.3_Intron|HCRTR1_uc001btd.2_Missense_Mutation_p.F84L|HCRTR1_uc010ogl.1_Missense_Mutation_p.F84L	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	84	Helical; Name=2; (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		CCAACTACTTCATTGTCAACC	0.612000												
KIAA0467	23334	broad.mit.edu	37	1	43891237	43891237	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:43891237A>C	uc001cjk.1	+	5	674	c.212A>C	c.(211-213)CAG>CCG	p.Q71P	KIAA0467_uc009vws.1_Missense_Mutation_p.Q913P	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	913						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GTGGAGCCACAGTATGGGCGA	0.557000												
DMAP1	55929	broad.mit.edu	37	1	44684006	44684006	+	Silent	SNP	G	G	A	rs145462822	byFrequency	TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:44684006G>A	uc001clq.1	+	5	497	c.417G>A	c.(415-417)TCG>TCA	p.S139S	DMAP1_uc010okt.1_Missense_Mutation_p.R178Q|DMAP1_uc001clr.1_Silent_p.S139S|DMAP1_uc001cls.1_Silent_p.S139S|DMAP1_uc010oku.1_Intron	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	139					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					CTGTGTACTCGGAGCAGGAGT	0.562000											OREG0013437	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
NFIA	4774	broad.mit.edu	37	1	61824865	61824865	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:61824865G>C	uc001czw.2	+	6	1349	c.865G>C	c.(865-867)GGT>CGT	p.G289R	NFIA_uc001czy.2_Missense_Mutation_p.G281R|NFIA_uc010oos.1_Missense_Mutation_p.G334R|NFIA_uc001czv.2_Missense_Mutation_p.G289R	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	289					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						GGACAGTCCTGGTGAGGAGCC	0.517000												
NEGR1	257194	broad.mit.edu	37	1	72163810	72163810	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:72163810T>G	uc001dfw.2	-	4	648	c.548A>C	c.(547-549)GAA>GCA	p.E183A	NEGR1_uc001dfv.2_Missense_Mutation_p.E55A|NEGR1_uc010oqs.1_Intron	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	183	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TTGTCCATTTTCAAATGGTTT	0.373000												
LPHN2	23266	broad.mit.edu	37	1	82436124	82436124	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:82436124A>G	uc001dit.3	+	15	2990	c.2809A>G	c.(2809-2811)AAA>GAA	p.K937E	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.K937E|LPHN2_uc001div.2_Missense_Mutation_p.K937E|LPHN2_uc009wcd.2_Missense_Mutation_p.K937E|LPHN2_uc001diw.2_Missense_Mutation_p.K521E|LPHN2_uc009wce.1_Missense_Mutation_p.K23E	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	950	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATATTCAAGGAAAAAATATTA	0.378000												
HSD3B1	3283	broad.mit.edu	37	1	120056814	120056814	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:120056814C>T	uc001ehv.1	+	4	813	c.668C>T	c.(667-669)CCA>CTA	p.P223L	HSD3B1_uc001ehw.2_Missense_Mutation_p.P225L	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	223					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	ACTGTTAACCCAGTCTATGTT	0.517000												
PIP5K1A	8394	broad.mit.edu	37	1	151211637	151211637	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:151211637G>T	uc001exj.2	+	11	1713	c.1261G>T	c.(1261-1263)GCC>TCC	p.A421S	PIP5K1A_uc001exi.2_Missense_Mutation_p.A408S|PIP5K1A_uc010pcu.1_Missense_Mutation_p.A381S|PIP5K1A_uc001exk.2_Missense_Mutation_p.A408S|PIP5K1A_uc010pcv.1_Missense_Mutation_p.A178S	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	421	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTCTTGGAAAGCCCTGGTACA	0.373000												
LCE1A	353131	broad.mit.edu	37	1	152800031	152800031	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:152800031A>C	uc010pdw.1	+	1	83	c.83A>C	c.(82-84)AAG>ACG	p.K28T		NM_178348	NP_848125	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	28	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			cccactcctaagtgcccccca	0.423000												
PMVK	10654	broad.mit.edu	37	1	154904868	154904868	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:154904868A>C	uc001ffq.2	-	2	442	c.119T>G	c.(118-120)GTC>GGC	p.V40G		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	40					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GAGCCGGAGGACAGCACAGAC	0.532000												
BCAN	63827	broad.mit.edu	37	1	156622677	156622677	+	Silent	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:156622677C>A	uc001fpp.2	+	8	2271	c.1935C>A	c.(1933-1935)CCC>CCA	p.P645P	BCAN_uc001fpo.2_Silent_p.P645P	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	645					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCGTGGTCCCCGCATCAGGTA	0.587000												
OR10K2	391107	broad.mit.edu	37	1	158390187	158390187	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158390187T>G	uc010pii.1	-	1	470	c.470A>C	c.(469-471)CAG>CCG	p.Q157P		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TGTGATGATCTGTGCAACAGT	0.493000												
OR10K2	391107	broad.mit.edu	37	1	158390391	158390391	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158390391T>G	uc010pii.1	-	1	266	c.266A>C	c.(265-267)AAG>ACG	p.K89T		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AATGGTCTTCTTCTGGGACAG	0.483000												
OR10K1	391109	broad.mit.edu	37	1	158435416	158435416	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158435416G>T	uc010pij.1	+	1	65	c.65G>T	c.(64-66)AGG>ATG	p.R22M		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCCCTGGCCAGGCTGCAGCAG	0.517000												
OR10Z1	128368	broad.mit.edu	37	1	158576978	158576978	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158576978T>C	uc010pio.1	+	1	750	c.750T>C	c.(748-750)ATT>ATC	p.I250I		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TGGTCATTATTCATTATGGCT	0.522000												
SPTA1	6708	broad.mit.edu	37	1	158583547	158583547	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158583547T>C	uc001fst.1	-	50	7152	c.6953A>G	c.(6952-6954)AAG>AGG	p.K2318R		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2318	EF-hand 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTTCTCAAACTTGGGCTCATG	0.537000												
SPTA1	6708	broad.mit.edu	37	1	158606546	158606546	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158606546T>G	uc001fst.1	-	37	5394	c.5195A>C	c.(5194-5196)AAG>ACG	p.K1732T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1732	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCGTATCAACTTCTCCCTAAA	0.473000												
SPTA1	6708	broad.mit.edu	37	1	158615013	158615013	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158615013G>A	uc001fst.1	-	29	4358	c.4159C>T	c.(4159-4161)CGC>TGC	p.R1387C		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1387	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATCTTCTTGCGTTTTTCCCAA	0.433000												
SPTA1	6708	broad.mit.edu	37	1	158651331	158651331	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158651331A>G	uc001fst.1	-	4	716	c.517T>C	c.(517-519)TGG>CGG	p.W173R		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	173	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCTCCAATCCACTCTAAGATG	0.522000												
PYHIN1	149628	broad.mit.edu	37	1	158908331	158908331	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:158908331A>G	uc001ftb.2	+	3	655	c.410A>G	c.(409-411)CAG>CGG	p.Q137R	PYHIN1_uc001fta.3_Missense_Mutation_p.Q137R|PYHIN1_uc001ftc.2_Missense_Mutation_p.Q128R|PYHIN1_uc001ftd.2_Missense_Mutation_p.Q137R|PYHIN1_uc001fte.2_Missense_Mutation_p.Q128R	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	137					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					CTTGGACCTCAGGTAAGCTTC	0.488000												
FCER1A	2205	broad.mit.edu	37	1	159276003	159276003	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:159276003A>G	uc001ftq.2	+	5	656	c.557A>G	c.(556-558)GAG>GGG	p.E186G		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	186	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CTGGACTATGAGTCTGAGCCC	0.458000												
OR10J1	26476	broad.mit.edu	37	1	159410501	159410501	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:159410501A>C	uc010piv.1	+	1	953	c.953A>C	c.(952-954)AAG>ACG	p.K318T	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	318	Cytoplasmic (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					GTTGGTGGGAAGTTTTCCTGA	0.488000												
APCS	325	broad.mit.edu	37	1	159558396	159558396	+	Silent	SNP	T	T	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:159558396T>A	uc001ftv.2	+	2	666	c.570T>A	c.(568-570)TCT>TCA	p.S190S		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	190	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					ATATCCTGTCTGCCTATCAGG	0.502000												
VANGL2	57216	broad.mit.edu	37	1	160394940	160394940	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:160394940T>C	uc001fwb.1	+	9	1637	c.1338T>C	c.(1336-1338)CCT>CCC	p.P446P	VANGL2_uc001fwc.1_Silent_p.P446P	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	446	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CGGCTGGACCTACCATCCAGT	0.557000												
HMCN1	83872	broad.mit.edu	37	1	185992242	185992242	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:185992242C>A	uc001grq.1	+	36	5935	c.5706C>A	c.(5704-5706)AAC>AAA	p.N1902K		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1902	Ig-like C2-type 16.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGGCTACCAACGCAGCTGGAG	0.388000												
CFH	3075	broad.mit.edu	37	1	196684839	196684839	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:196684839A>C	uc001gtj.3	+	11	1876	c.1636A>C	c.(1636-1638)AGC>CGC	p.S546R		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	546	Sushi 9.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CAATACTGGAAGCACCACTGG	0.264000												
NAV1	89796	broad.mit.edu	37	1	201752711	201752711	+	Silent	SNP	G	G	A	rs144457633		TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:201752711G>A	uc001gwu.2	+	7	2882	c.2535G>A	c.(2533-2535)CCG>CCA	p.P845P	NAV1_uc001gwv.1_Silent_p.P353P|NAV1_uc001gww.1_Silent_p.P454P|NAV1_uc001gwx.2_Silent_p.P454P|NAV1_uc001gwy.1_Silent_p.P226P	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	845					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CCCCCAGTCCGGCACCCATCC	0.547000												
KLHL12	59349	broad.mit.edu	37	1	202861698	202861698	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:202861698C>T	uc001gyo.1	-	12	1870	c.1670G>A	c.(1669-1671)CGC>CAC	p.R557H	KLHL12_uc001gym.1_3'UTR|KLHL12_uc001gyn.1_3'UTR|KLHL12_uc010pqc.1_Missense_Mutation_p.R595H	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	557	Kelch 6.|Interaction with DVL3.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			AGCATCACAGCGCTGGGTTCC	0.493000												
CD34	947	broad.mit.edu	37	1	208061155	208061155	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:208061155G>A	uc001hgw.1	-	8	1344	c.1086C>T	c.(1084-1086)AAC>AAT	p.N362N	CD34_uc001hgv.1_Silent_p.N204N|CD34_uc001hgx.1_3'UTR|CD34_uc010psj.1_Silent_p.N227N	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	362	Cytoplasmic (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						GGCCGGTCCCGTTTTCCTGAG	0.607000												
AIDA	64853	broad.mit.edu	37	1	222849460	222849460	+	Silent	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:222849460G>C	uc001hnn.2	-	7	766	c.561C>G	c.(559-561)CCC>CCG	p.P187P	AIDA_uc001hno.2_RNA|AIDA_uc010pus.1_Silent_p.P163P	NM_022831	NP_073742	Q96BJ3	AIDA_HUMAN	axin interactor, dorsalization associated	187	Axin-binding (By similarity).				dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity						0						CTGTAATATAGGGATCGATGC	0.363000												
C1orf55	163859	broad.mit.edu	37	1	226180108	226180108	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:226180108C>T	uc001hpu.3	-	4	564	c.511G>A	c.(511-513)GTC>ATC	p.V171I	C1orf55_uc001hpv.2_Missense_Mutation_p.V171I	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	171										lung(1)	1	Breast(184;0.197)					CCTTTGAGGACGGAATCCTCC	0.527000												
OBSCN	84033	broad.mit.edu	37	1	228434396	228434396	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:228434396G>A	uc009xez.1	+	13	3969	c.3925G>A	c.(3925-3927)GCG>ACG	p.A1309T	OBSCN_uc001hsn.2_Missense_Mutation_p.A1309T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1309	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CATAGAGGCTGCGGGCTGCAT	0.637000												
EGLN1	54583	broad.mit.edu	37	1	231556836	231556836	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:231556836C>T	uc001huv.2	-	1	3955	c.799G>A	c.(799-801)GAA>AAA	p.E267K	EGLN1_uc001huu.3_5'Flank	NM_022051	NP_071334	Q9GZT9	EGLN1_HUMAN	egl nine homolog 1	267					negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding				0		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)	CCAATGGTTTCGCAGCCGGGC	0.567000												
DISC1	27185	broad.mit.edu	37	1	231954086	231954086	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:231954086T>C	uc001huz.2	+	9	1857	c.1804T>C	c.(1804-1806)TGG>CGG	p.W602R	TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.W591R|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.W557R|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.W557R|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.W591R|TSNAX-DISC1_uc010pwk.1_Silent_p.S556S|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwr.1_Missense_Mutation_p.W602R|DISC1_uc010pws.1_Silent_p.S567S|DISC1_uc010pwt.1_Missense_Mutation_p.L549P|DISC1_uc010pwu.1_Missense_Mutation_p.L199P|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.W602R|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.W602R|DISC1_uc010pxb.1_Missense_Mutation_p.W602R|DISC1_uc010pxc.1_Intron|DISC1_uc010pxd.1_Missense_Mutation_p.W247R|DISC1_uc010pxe.1_Missense_Mutation_p.W602R|DISC1_uc009xfr.2_Missense_Mutation_p.W557R|DISC1_uc010pxf.1_Missense_Mutation_p.W602R|DISC1_uc010pxg.1_Intron|DISC1_uc010pxh.1_Missense_Mutation_p.W634R|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Missense_Mutation_p.W247R|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.W480R|DISC1_uc010pxn.1_Missense_Mutation_p.W247R|DISC1_uc001hva.2_Missense_Mutation_p.W602R|DISC2_uc001hvd.2_RNA	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	602	Potential.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Interaction with TRAF3IP1.|Interaction with ATF4 and ATF5.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				AAACCATTTCTGGACGGCTAA	0.473000												
SIPA1L2	57568	broad.mit.edu	37	1	232561464	232561464	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:232561464A>G	uc001hvg.2	-	16	4659	c.4501T>C	c.(4501-4503)TTT>CTT	p.F1501L	SIPA1L2_uc001hvf.2_Missense_Mutation_p.F575L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1501					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAACTGCCAAAGGAGGACCCC	0.597000												
FMN2	56776	broad.mit.edu	37	1	240555824	240555824	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:240555824A>C	uc010pyd.1	+	15	5097	c.4872A>C	c.(4870-4872)CAA>CAC	p.Q1624H	FMN2_uc010pye.1_Missense_Mutation_p.Q1628H|FMN2_uc010pyf.1_Missense_Mutation_p.Q239H|FMN2_uc010pyg.1_Missense_Mutation_p.Q220H	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1624	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAATTGACCAAGAGGCAGAGG	0.343000												
OR2L2	26246	broad.mit.edu	37	1	248201578	248201578	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:248201578T>G	uc001idw.2	+	1	105	c.9T>G	c.(7-9)AAT>AAG	p.N3K	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CCATGGAAAATTACAATCAAA	0.299000												
OR2T4	127074	broad.mit.edu	37	1	248525557	248525557	+	Silent	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr1:248525557A>C	uc001ieh.1	+	1	675	c.675A>C	c.(673-675)TCA>TCC	p.S225S		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	225	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAGACACCTCACTCTATGAGA	0.483000												
PTCHD3	374308	broad.mit.edu	37	10	27703150	27703150	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:27703150C>T	uc001itu.2	-	1	148	c.30G>A	c.(28-30)CCG>CCA	p.P10P		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	10					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GCTCCGGCCCCGGCCTGGGCT	0.622000												
ANKRD30A	91074	broad.mit.edu	37	10	37421204	37421204	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:37421204A>G	uc001iza.1	+	4	478	c.379A>G	c.(379-381)AGA>GGA	p.R127G		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	183	ANK 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CATAACGAAAAGAAGTGAGCA	0.289000												
PCDH15	65217	broad.mit.edu	37	10	55581852	55581852	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:55581852T>G	uc001jju.1	-	33	6029	c.5634A>C	c.(5632-5634)GAA>GAC	p.E1878D	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Missense_Mutation_p.E732D|PCDH15_uc010qhv.1_Missense_Mutation_p.E1875D|PCDH15_uc010qhw.1_Missense_Mutation_p.E1838D|PCDH15_uc010qhx.1_Missense_Mutation_p.E1809D|PCDH15_uc010qhy.1_Missense_Mutation_p.E1885D|PCDH15_uc010qhz.1_Missense_Mutation_p.E1880D|PCDH15_uc010qia.1_Missense_Mutation_p.E1858D|PCDH15_uc010qib.1_Missense_Mutation_p.E1855D	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1878	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCCTTTTGGTTCTCTCTGAG	0.393000										HNSCC(58;0.16)		
DDX50	79009	broad.mit.edu	37	10	70666568	70666568	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:70666568A>G	uc001jou.2	+	2	296	c.189A>G	c.(187-189)AAA>AAG	p.K63K	DDX50_uc001jot.2_Silent_p.K63K|DDX50_uc010qjc.1_Silent_p.K63K	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	63						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1						AGGCCAAAAAATCTAAAATGA	0.378000												
GRID1	2894	broad.mit.edu	37	10	87489289	87489289	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:87489289A>G	uc001kdl.1	-	9	1417	c.1316T>C	c.(1315-1317)CTT>CCT	p.L439P	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.L10P	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	439	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CACCACTTTAAGAGTCAATCC	0.512000										Multiple Myeloma(13;0.14)		
AGAP11	119385	broad.mit.edu	37	10	88768495	88768495	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:88768495G>T	uc001kee.2	+	12	1690	c.486G>T	c.(484-486)ATG>ATT	p.M162I	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	162	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GTGATTATATGAAGAATATTC	0.443000												
CC2D2B	387707	broad.mit.edu	37	10	97791581	97791581	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:97791581C>T	uc001kll.2	+	9	984	c.785C>T	c.(784-786)ACG>ATG	p.T262M	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_RNA|CC2D2B_uc010qop.1_Missense_Mutation_p.T341M|uc009xvb.1_Intron	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	262										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		ATCCAGGTCACGGGATTTCCC	0.388000												
INA	9118	broad.mit.edu	37	10	105037931	105037931	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:105037931G>A	uc001kws.2	+	1	1012	c.963G>A	c.(961-963)GCG>GCA	p.A321A	uc001kwr.2_5'Flank|INA_uc009xxj.2_Silent_p.A321A	NM_032727	NP_116116	Q16352	AINX_HUMAN	internexin neuronal intermediate filament	321	Coil 2.|Rod.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			ovary(1)|breast(1)	2				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		AGCTGCAGGCGCGCACCATCG	0.677000												
SORCS1	114815	broad.mit.edu	37	10	108923912	108923912	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:108923912T>C	uc001kym.2	-	1	381	c.373A>G	c.(373-375)AGT>GGT	p.S125G	SORCS1_uc001kyl.2_Missense_Mutation_p.S125G|SORCS1_uc009xxs.2_Missense_Mutation_p.S125G|SORCS1_uc001kyn.1_Missense_Mutation_p.S125G|SORCS1_uc001kyo.2_Missense_Mutation_p.S125G	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	125	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGGCTCCGACTCGCGCCCTCT	0.701000												
C10orf96	374355	broad.mit.edu	37	10	118137945	118137945	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:118137945G>C	uc001lck.2	+	8	915	c.664G>C	c.(664-666)GAA>CAA	p.E222Q		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	222										ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		ACTTAAAAAAGAATTAGAACT	0.279000												
PRLHR	2834	broad.mit.edu	37	10	120353892	120353892	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:120353892C>T	uc001ldp.1	-	2	1004	c.865G>A	c.(865-867)GTC>ATC	p.V289I		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	289	Helical; Name=6; (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		AGCCAGCAGACGGCGAACACC	0.692000												
CPXM2	119587	broad.mit.edu	37	10	125506504	125506504	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:125506504T>C	uc001lhk.1	-	14	2372	c.2047A>G	c.(2047-2049)AAC>GAC	p.N683D	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	683					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TCTCCAGGGTTCAGGAGGCGC	0.537000												
C10orf137	26098	broad.mit.edu	37	10	127438041	127438041	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:127438041G>T	uc001liq.1	+	22	3477	c.3184G>T	c.(3184-3186)GCC>TCC	p.A1062S	C10orf137_uc001lio.1_Missense_Mutation_p.A1028S|C10orf137_uc001lip.1_Missense_Mutation_p.A766S|C10orf137_uc001lis.1_Missense_Mutation_p.A388S|C10orf137_uc001lit.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	1062					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTACAGCAAGGCCGCAAAGCT	0.463000												
EBF3	253738	broad.mit.edu	37	10	131666103	131666103	+	Silent	SNP	G	G	A	rs149960200	by1000genomes	TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr10:131666103G>A	uc001lki.1	-	9	887	c.828C>T	c.(826-828)GGC>GGT	p.G276G		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	285	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AGAAGTTGTCGCCAATTATGA	0.567000												
MUC5B	727897	broad.mit.edu	37	11	1270309	1270309	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:1270309T>C	uc009ycr.1	+	51	13744	c.13618T>C	c.(13618-13620)TCC>CCC	p.S4540P	MUC5B_uc001ltb.2_Missense_Mutation_p.S4070P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4067	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCAGCCCTGTCCAGCCCTCA	0.687000												
IGF2	3481	broad.mit.edu	37	11	2154256	2154256	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:2154256G>A	uc009yde.2	-	4	607	c.504C>T	c.(502-504)CAC>CAT	p.H168H	IGF2_uc001lvf.2_RNA|IGF2_uc001lvg.2_Silent_p.H168H|IGF2_uc009ydf.2_Silent_p.H224H|IGF2_uc001lvh.2_Silent_p.H168H|INS-IGF2_uc001lvi.2_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	168					glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GGGCGCCCCCGTGGGCGGGGT	0.682000												
OR52R1	119695	broad.mit.edu	37	11	4825639	4825639	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:4825639A>G	uc010qym.1	-	1	209	c.209T>C	c.(208-210)GTT>GCT	p.V70A		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	Error:Variant_position_missing_in_Q8NGF1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTGCTGGGAACGCAATCTAC	0.458000												
OR52N4	390072	broad.mit.edu	37	11	5776163	5776163	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:5776163T>C	uc001mbu.2	+	1	241	c.193T>C	c.(193-195)TTG>CTG	p.L65L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		GTACTACTTCTTGGCCATGCT	0.448000												
MRVI1	10335	broad.mit.edu	37	11	10648081	10648081	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:10648081A>G	uc010rcc.1	-	9	1186	c.800T>C	c.(799-801)GTG>GCG	p.V267A	MRVI1_uc001miw.2_Missense_Mutation_p.V258A|MRVI1_uc010rcb.1_Missense_Mutation_p.V259A|MRVI1_uc009ygb.1_5'UTR|MRVI1_uc001mix.2_5'UTR|MRVI1_uc001miz.2_Missense_Mutation_p.V176A|MRVI1_uc009ygc.1_Missense_Mutation_p.V176A|MRVI1_uc010rcd.1_Intron|MRVI1_uc009ygd.1_5'UTR|MRVI1_uc010rce.1_Intron	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	240					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		GCCCTGAGACACTTTCCTCTG	0.532000												
LRRC4C	57689	broad.mit.edu	37	11	40137506	40137506	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:40137506T>C	uc001mxa.1	-	2	2301	c.337A>G	c.(337-339)AGA>GGA	p.R113G	LRRC4C_uc001mxc.1_Missense_Mutation_p.R109G|LRRC4C_uc001mxd.1_Missense_Mutation_p.R109G|LRRC4C_uc001mxb.1_Missense_Mutation_p.R109G	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	113	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCAATGGTTCTGATATGGTTC	0.438000												
CKAP5	9793	broad.mit.edu	37	11	46774965	46774965	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:46774965A>C	uc001ndi.1	-	37	5062	c.4952T>G	c.(4951-4953)CTG>CGG	p.L1651R	CKAP5_uc009ylg.1_Missense_Mutation_p.L1537R|CKAP5_uc001ndj.1_Missense_Mutation_p.L1591R|CKAP5_uc001ndh.1_Missense_Mutation_p.L580R	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1651					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CCGAGAATCCAGCATTAAGGT	0.493000												
LRP4	4038	broad.mit.edu	37	11	46890212	46890212	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:46890212G>A	uc001ndn.3	-	33	5036	c.4890C>T	c.(4888-4890)GCC>GCT	p.A1630A	uc001ndl.2_Intron	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1630	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CCGAGGCTCTGGCAAAGCAGA	0.567000												
OR5D16	390144	broad.mit.edu	37	11	55606243	55606243	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:55606243A>G	uc010rio.1	+	1	16	c.16A>G	c.(16-18)AGA>GGA	p.R6G		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TCTGACAGAGAGAAATACGAC	0.413000												
TCN1	6947	broad.mit.edu	37	11	59626717	59626717	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:59626717C>T	uc001noj.2	-	5	678	c.580G>A	c.(580-582)GCT>ACT	p.A194T		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	194					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGGTCAGAGCCAGGACAGCC	0.294000												
MS4A2	2206	broad.mit.edu	37	11	59857259	59857259	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:59857259C>A	uc001nop.2	+	2	253	c.151C>A	c.(151-153)CTG>ATG	p.L51M	MS4A2_uc009ymu.2_Missense_Mutation_p.L51M	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	51	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	GCATACATGGCTGACAGTTTT	0.473000												
B3GAT3	26229	broad.mit.edu	37	11	62383980	62383980	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:62383980G>A	uc001ntw.2	-	4	936	c.907C>T	c.(907-909)CGG>TGG	p.R303W	B3GAT3_uc009ynz.2_Missense_Mutation_p.R296W|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Missense_Mutation_p.R303W	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	303	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						TCCCTTACCCGAGTGCAGTTG	0.562000												
SNX32	254122	broad.mit.edu	37	11	65617659	65617659	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:65617659G>A	uc001ofr.2	+	4	418	c.291G>A	c.(289-291)TCG>TCA	p.S97S	SNX32_uc009yqt.2_3'UTR|SNX32_uc010rop.1_Missense_Mutation_p.R137Q	NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B	97	PX.				cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		TTGAGGCTTCGAGGGAAAAGC	0.602000												
PITPNM1	9600	broad.mit.edu	37	11	67260437	67260437	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:67260437G>A	uc001olx.2	-	22	3628	c.3439C>T	c.(3439-3441)CGT>TGT	p.R1147C	PITPNM1_uc001olw.2_Missense_Mutation_p.R429C|PITPNM1_uc001oly.2_Missense_Mutation_p.R1147C|PITPNM1_uc001olz.2_Missense_Mutation_p.R1146C	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	1147					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CGCACGGCACGGCCCACGATG	0.647000												
UVRAG	7405	broad.mit.edu	37	11	75851978	75851978	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:75851978G>A	uc001oxc.2	+	15	1862	c.1621G>A	c.(1621-1623)GAG>AAG	p.E541K	UVRAG_uc010rrw.1_Missense_Mutation_p.E440K|UVRAG_uc001oxd.2_Missense_Mutation_p.E169K|UVRAG_uc010rrx.1_Missense_Mutation_p.E169K|UVRAG_uc010rry.1_Missense_Mutation_p.E97K	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	541					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						GGGAGAGACCGAGAGAAAGAT	0.488000												
DSCAML1	57453	broad.mit.edu	37	11	117332215	117332215	+	Silent	SNP	G	G	A	rs145257382		TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:117332215G>A	uc001prh.1	-	18	3545	c.3543C>T	c.(3541-3543)GGC>GGT	p.G1181G		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1121	Fibronectin type-III 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTTTGAGGACGCCATTGAGGG	0.632000												
C11orf63	79864	broad.mit.edu	37	11	122756770	122756770	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:122756770C>T	uc001pym.2	+	2	510	c.213C>T	c.(211-213)CCC>CCT	p.P71P	C11orf63_uc001pyl.1_Silent_p.P71P	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	71										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GTATGGAGCCCGACAGCTTAG	0.512000												
PARP11	57097	broad.mit.edu	37	12	3923335	3923335	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:3923335T>C	uc001qmk.1	-	6	602	c.547A>G	c.(547-549)AAA>GAA	p.K183E	PARP11_uc001qml.2_Missense_Mutation_p.K190E|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_Missense_Mutation_p.K109E|PARP11_uc001qmn.2_Missense_Mutation_p.K109E	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	183	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			CCTCTTTTTTTCTTGAGCTGA	0.348000												
ANO2	57101	broad.mit.edu	37	12	5908717	5908717	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:5908717C>T	uc001qnm.2	-	10	1071	c.999G>A	c.(997-999)GCG>GCA	p.A333A		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	338	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CTCCATAGCGCGCCCATTCTT	0.418000												
KLRG1	10219	broad.mit.edu	37	12	9162086	9162086	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:9162086A>G	uc001qvh.2	+	5	534	c.523A>G	c.(523-525)AGC>GGC	p.S175G	KLRG1_uc001qvg.2_Missense_Mutation_p.S175G	NM_005810	NP_005801	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G,	175	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			central_nervous_system(1)	1						TCAAGCCTCAAGCTGTGAAGT	0.433000												
A2M	2	broad.mit.edu	37	12	9231846	9231846	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:9231846T>G	uc001qvk.1	-	25	3226	c.3113A>C	c.(3112-3114)AAC>ACC	p.N1038T	A2M_uc001qvj.1_Missense_Mutation_p.N80T|A2M_uc009zgk.1_Missense_Mutation_p.N888T	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1038					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TTACCAGGTGTTGCCCTGGTT	0.284000												
CLEC12A	160364	broad.mit.edu	37	12	10133243	10133243	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:10133243A>C	uc001qwr.3	+	4	630	c.442A>C	c.(442-444)AGT>CGT	p.S148R	CLEC12A_uc001qwq.2_Missense_Mutation_p.S158R|CLEC12A_uc001qws.3_Missense_Mutation_p.S115R|CLEC12A_uc001qwt.2_Missense_Mutation_p.S77R	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor	148	Extracellular (Potential).|C-type lectin.					integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1						TTATTTCCTAAGTGATGATGT	0.413000												
LRRK2	120892	broad.mit.edu	37	12	40657648	40657648	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:40657648A>C	uc001rmg.3	+	14	1722	c.1601A>C	c.(1600-1602)AAA>ACA	p.K534T	LRRK2_uc001rmh.1_Missense_Mutation_p.K156T	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	534					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AATATGGTTAAAAAACAGTGT	0.294000												
SLC38A4	55089	broad.mit.edu	37	12	47186787	47186787	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:47186787G>T	uc001rpi.2	-	3	467	c.68C>A	c.(67-69)GCT>GAT	p.A23D	SLC38A4_uc001rpj.2_Missense_Mutation_p.A23D|SLC38A4_uc009zkl.2_Missense_Mutation_p.A23D	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	23	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					GCTATCTGGAGCACTTTCTCC	0.433000												
KRT84	3890	broad.mit.edu	37	12	52774882	52774882	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:52774882A>C	uc001sah.1	-	6	1233	c.1185T>G	c.(1183-1185)ATT>ATG	p.I395M		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	395	Rod.|Coil 2.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGGCGTGCTCAATCTCTGCCT	0.557000												
TENC1	23371	broad.mit.edu	37	12	53457541	53457541	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:53457541G>A	uc001sbp.2	+	29	4240	c.4105G>A	c.(4105-4107)GTG>ATG	p.V1369M	TENC1_uc001sbl.2_Missense_Mutation_p.V1245M|TENC1_uc001sbn.2_Missense_Mutation_p.V1379M|TENC1_uc001sbq.2_Missense_Mutation_p.V767M|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Missense_Mutation_p.V862M|TENC1_uc001sbs.2_Missense_Mutation_p.V188M	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1369					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						CTTTGGTTTCGTGGCCAAGAA	0.537000												
STAT6	6778	broad.mit.edu	37	12	57501478	57501478	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:57501478G>A	uc009zpe.2	-	3	416	c.165C>T	c.(163-165)GCC>GCT	p.A55A	STAT6_uc009zpf.2_Silent_p.A55A|STAT6_uc001sna.2_Silent_p.A55A|STAT6_uc010srb.1_5'UTR|STAT6_uc010src.1_Intron|STAT6_uc010srd.1_Intron|STAT6_uc009zpg.2_Silent_p.A104A	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	55					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						CTGAAAGTAGGGCACTAGCCA	0.612000												
LRP1	4035	broad.mit.edu	37	12	57554830	57554830	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:57554830C>T	uc001snd.2	+	13	2600	c.2134C>T	c.(2134-2136)CGC>TGC	p.R712C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	712	LDL-receptor class B 7.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCGGCTGGGCGCCTCTACTG	0.597000												
ACSS3	79611	broad.mit.edu	37	12	81593201	81593201	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:81593201C>T	uc001szl.1	+	9	1423	c.1332C>T	c.(1330-1332)GTC>GTT	p.V444V	ACSS3_uc001szm.1_Silent_p.V443V|ACSS3_uc001szn.1_Silent_p.V126V	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	444						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GAGTACCTGTCTTAGACCATT	0.393000												
APAF1	317	broad.mit.edu	37	12	99077029	99077029	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:99077029G>A	uc001tfz.2	+	15	2732	c.2155G>A	c.(2155-2157)GGG>AGG	p.G719R	APAF1_uc001tfy.2_Missense_Mutation_p.G708R|APAF1_uc001tga.2_Missense_Mutation_p.G708R|APAF1_uc001tgb.2_Missense_Mutation_p.G719R|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Missense_Mutation_p.G128R	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	719	WD 3.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	CTTAGCCACTGGGTCAAGTGA	0.393000												
UNG	7374	broad.mit.edu	37	12	109541289	109541289	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:109541289C>G	uc001tnz.1	+	6	744	c.674C>G	c.(673-675)TCT>TGT	p.S225C	UNG_uc001toa.1_Missense_Mutation_p.S216C	NM_080911	NP_550433	P13051	UNG_HUMAN	uracil-DNA glycosylase isoform UNG2	225					base-excision repair|interspecies interaction between organisms	mitochondrion|nucleus	protein binding|uracil DNA N-glycosylase activity			lung(1)|central_nervous_system(1)	2						CAAGCCAACTCTCATAAGGAG	0.498000								BER_DNA_glycosylases	Immune_Deficiency_with_Hyper-IgM			
CCDC60	160777	broad.mit.edu	37	12	119943022	119943022	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:119943022G>C	uc001txe.2	+	7	1262	c.797G>C	c.(796-798)AGT>ACT	p.S266T	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	266										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GAGCCCCCAAGTGTGAACACC	0.562000												
CLIP1	6249	broad.mit.edu	37	12	122845597	122845597	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:122845597G>C	uc001ucg.1	-	4	1020	c.914C>G	c.(913-915)GCC>GGC	p.A305G	CLIP1_uc001uch.1_Missense_Mutation_p.A305G|CLIP1_uc001uci.1_Missense_Mutation_p.A305G|CLIP1_uc001ucj.1_Missense_Mutation_p.A6G|CLIP1_uc010tae.1_Missense_Mutation_p.A305G	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	305	Ser-rich.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTTCAGGCTGGCGGACGTGGT	0.602000												
MMP17	4326	broad.mit.edu	37	12	132325159	132325159	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr12:132325159C>T	uc001ujc.1	+	4	563	c.464C>T	c.(463-465)ACG>ATG	p.T155M	MMP17_uc001ujd.1_Missense_Mutation_p.T71M	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	155					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		GGGCACGACACGGTGCGTGCA	0.667000												
SACS	26278	broad.mit.edu	37	13	23907855	23907855	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:23907855A>C	uc001uon.2	-	10	10749	c.10160T>G	c.(10159-10161)CTT>CGT	p.L3387R	SACS_uc001uoo.2_Missense_Mutation_p.L3240R|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3387					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ATACATCAAAAGTGCCTCAAA	0.348000												
RNF17	56163	broad.mit.edu	37	13	25444738	25444738	+	Silent	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:25444738T>G	uc001upr.2	+	32	4349	c.4308T>G	c.(4306-4308)ACT>ACG	p.T1436T	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Silent_p.T1432T|RNF17_uc001ups.2_Silent_p.T1375T|RNF17_uc010aac.2_Silent_p.T628T|RNF17_uc010aad.2_Silent_p.T446T	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1436					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTATAGAAACTTCTAACCAGT	0.408000												
DCLK1	9201	broad.mit.edu	37	13	36686166	36686166	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:36686166A>G	uc001uvf.2	-	3	796	c.563T>C	c.(562-564)GTC>GCC	p.V188A		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	188	Doublecortin 2.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GATGATGGTGACCAGCTTGGG	0.532000												
SOHLH2	54937	broad.mit.edu	37	13	36748937	36748937	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:36748937A>T	uc001uvj.2	-	7	800	c.711T>A	c.(709-711)GAT>GAA	p.D237E	SOHLH2_uc010tei.1_Missense_Mutation_p.D314E	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	237	Helix-loop-helix motif.				cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CTGAAGCCGCATCATTCTTTC	0.423000												
PCDH9	5101	broad.mit.edu	37	13	67205373	67205373	+	Silent	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:67205373A>C	uc001vik.2	-	4	4001	c.3309T>G	c.(3307-3309)ACT>ACG	p.T1103T	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Silent_p.T1069T|PCDH9_uc010thl.1_Silent_p.T1061T	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1103	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CATCTGCTTCAGTCCTCTTGT	0.498000												
CLN5	1203	broad.mit.edu	37	13	77574734	77574734	+	Nonsense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:77574734T>G	uc001vkc.2	+	4	882	c.854T>G	c.(853-855)TTA>TGA	p.L285*		NM_006493	NP_006484	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	236					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		AAATTTGTGTTAAGGACCTTT	0.378000												
SLC10A2	6555	broad.mit.edu	37	13	103703770	103703770	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:103703770C>T	uc001vpy.3	-	4	1195	c.598G>A	c.(598-600)GCG>ACG	p.A200T		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	200	Helical; (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity	p.A200A(1)		ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATGGCGCCCGCGATGGACCCA	0.438000												
NOVA1	4857	broad.mit.edu	37	14	26917993	26917993	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr14:26917993T>C	uc001wpy.2	-	5	1014	c.696A>G	c.(694-696)AAA>AAG	p.K232K	NOVA1_uc001wpz.2_Silent_p.K208K|NOVA1_uc001wqa.2_Silent_p.K110K	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	235	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GTTCAACAGCTTTTCGGTTTT	0.473000												
MDGA2	161357	broad.mit.edu	37	14	47426697	47426697	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr14:47426697A>G	uc001wwj.3	-	9	1958	c.1762T>C	c.(1762-1764)TTT>CTT	p.F588L	MDGA2_uc001wwi.3_Missense_Mutation_p.F359L|MDGA2_uc010ani.2_Missense_Mutation_p.F148L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	588	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TGAGAGTCAAATTGACCCGTC	0.448000												
PYGL	5836	broad.mit.edu	37	14	51383825	51383825	+	Splice_Site	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr14:51383825T>G	uc001wyu.2	-	8	983	c.856_splice	c.e8-1	p.F286_splice	PYGL_uc010tqq.1_Splice_Site_p.F252_splice|PYGL_uc001wyv.2_Splice_Site|PYGL_uc010anz.1_Splice_Site_p.F89_splice	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1						glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TTCAAAAAACTTCAAGCCAGA	0.438000												
KCNH5	27133	broad.mit.edu	37	14	63483661	63483661	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr14:63483661A>C	uc001xfx.2	-	2	136	c.85T>G	c.(85-87)TTA>GTA	p.L29V	KCNH5_uc001xfy.2_Missense_Mutation_p.L29V|KCNH5_uc001xfz.1_5'UTR|KCNH5_uc001xga.2_5'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	29	Cytoplasmic (Potential).|PAS.				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTTCCCAGTAAGAAACTTGAT	0.353000												
DIO2	1734	broad.mit.edu	37	14	80669144	80669144	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr14:80669144T>G	uc010tvq.1	-	4	1112	c.710A>C	c.(709-711)AAA>ACA	p.K237T	DIO2_uc010tvp.1_Missense_Mutation_p.K273T|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Missense_Mutation_p.K237T|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	237					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		ATAAGCAATTTTCTGTCTCTG	0.498000												
EML5	161436	broad.mit.edu	37	14	89168805	89168805	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr14:89168805G>C	uc001xxg.2	-	15	2409	c.2223C>G	c.(2221-2223)TAC>TAG	p.Y741*	EML5_uc001xxh.1_5'UTR	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	741	WD 11.					cytoplasm|microtubule				ovary(3)	3						CTGTTGCCACGTAGTCTTTCA	0.368000												
ATXN3	4287	broad.mit.edu	37	14	92547369	92547369	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr14:92547369G>A	uc001yac.3	-	9	881	c.812C>T	c.(811-813)ACA>ATA	p.T271I	ATXN3_uc010aug.2_Missense_Mutation_p.T256I|ATXN3_uc001yad.3_Missense_Mutation_p.T216I|ATXN3_uc010auh.2_Missense_Mutation_p.T205I|ATXN3_uc001yae.3_Missense_Mutation_p.T173I|ATXN3_uc010twl.1_RNA	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	271					cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		TGTACCTGATGTCTGTGTCAT	0.343000												
TTBK2	146057	broad.mit.edu	37	15	43045040	43045040	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr15:43045040T>C	uc001zqo.2	-	14	2843	c.2404A>G	c.(2404-2406)ATC>GTC	p.I802V	TTBK2_uc010bcy.2_Missense_Mutation_p.I733V	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	802					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AGAGAGGAGATCTCAATACAA	0.408000												
SLC12A1	6557	broad.mit.edu	37	15	48522588	48522588	+	Splice_Site	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr15:48522588A>C	uc001zwn.3	+	7	1081	c.865_splice	c.e7-2	p.E289_splice	SLC12A1_uc010uew.1_Splice_Site_p.E95_splice|SLC12A1_uc010bem.2_Splice_Site_p.E289_splice|SLC12A1_uc010uex.1_Splice_Site_p.E289_splice|SLC12A1_uc001zwq.3_Splice_Site_p.E60_splice|SLC12A1_uc001zwr.3_Splice_Site_p.E16_splice	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2						potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TTGTTTCCCCAGGAGAGTGAT	0.393000												
ONECUT1	3175	broad.mit.edu	37	15	53049845	53049845	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr15:53049845G>A	uc002aci.1	-	2	1433	c.1305C>T	c.(1303-1305)AAC>AAT	p.N435N		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	435	Homeobox.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		TCCTTCTTGCGTTCATGAAGA	0.473000												
HERC1	8925	broad.mit.edu	37	15	63950881	63950881	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr15:63950881C>T	uc002amp.2	-	48	9609	c.9461G>A	c.(9460-9462)AGA>AAA	p.R3154K		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3154					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TAACGTTATTCTCCCAGAGGA	0.458000												
THSD4	79875	broad.mit.edu	37	15	71952875	71952875	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr15:71952875G>A	uc002atb.1	+	7	1238	c.1159G>A	c.(1159-1161)GGC>AGC	p.G387S	THSD4_uc002atd.1_Missense_Mutation_p.G61S|THSD4_uc010ukg.1_Missense_Mutation_p.G27S|THSD4_uc002ate.2_Missense_Mutation_p.G27S	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	387						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GCAGAGCATTGGCTGTGATGA	0.478000												
CLDN9	9080	broad.mit.edu	37	16	3063534	3063534	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr16:3063534G>A	uc010uwo.1	+	1	1078	c.171G>A	c.(169-171)CAG>CAA	p.Q57Q		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	57	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GCGTGGTGCAGAGCACGGGCC	0.662000												
CLDN6	9074	broad.mit.edu	37	16	3065603	3065603	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr16:3065603C>T	uc002csu.3	-	2	480	c.420G>A	c.(418-420)GCG>GCA	p.A140A		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	140	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TGATGGCATGCGCCGTCCAGC	0.622000												
SLC5A11	115584	broad.mit.edu	37	16	24902195	24902195	+	Missense_Mutation	SNP	G	G	A	rs61744722		TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr16:24902195G>A	uc002dmu.2	+	9	902	c.670G>A	c.(670-672)GCC>ACC	p.A224T	SLC5A11_uc002dms.2_Missense_Mutation_p.A160T|SLC5A11_uc010vcd.1_Missense_Mutation_p.A189T|SLC5A11_uc002dmt.2_Intron|SLC5A11_uc010vce.1_Missense_Mutation_p.A154T|SLC5A11_uc010bxt.2_Missense_Mutation_p.A160T	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	224	Helical; (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		TCTAGGTTTTGCCGCGGTTGG	0.542000												
HS3ST4	9951	broad.mit.edu	37	16	26147507	26147507	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr16:26147507T>G	uc002dof.2	+	2	1701	c.1309T>G	c.(1309-1311)TTG>GTG	p.L437V		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	437	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	p.L437L(1)		large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		ACCCTTCAACTTGATGTTTTA	0.473000												
TSNAXIP1	55815	broad.mit.edu	37	16	67861893	67861893	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr16:67861893C>A	uc002euj.2	+	16	2368	c.1974C>A	c.(1972-1974)AGC>AGA	p.S658R	TSNAXIP1_uc002euf.3_3'UTR|TSNAXIP1_uc010vka.1_Missense_Mutation_p.S712R|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.S643R|TSNAXIP1_uc002eug.3_Missense_Mutation_p.S366R|TSNAXIP1_uc002euh.3_Missense_Mutation_p.S366R|TSNAXIP1_uc002eui.3_Missense_Mutation_p.S366R|TSNAXIP1_uc002euk.2_Missense_Mutation_p.S391R	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	658					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		AGCCTGCAAGCTAGGAACTTG	0.532000												
TAT	6898	broad.mit.edu	37	16	71606201	71606201	+	Silent	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr16:71606201C>A	uc002fap.2	-	6	693	c.594G>T	c.(592-594)CTG>CTT	p.L198L		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	198					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCAGTTGTTTCAGGTCAATTT	0.408000												
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
MYH10	4628	broad.mit.edu	37	17	8526315	8526315	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr17:8526315A>C	uc002gll.2	-	2	346	c.250T>G	c.(250-252)TTT>GTT	p.F84V	MYH10_uc002glm.2_Missense_Mutation_p.F84V|MYH10_uc010cnx.2_Missense_Mutation_p.F84V	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	84	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						ACCTTGGAAAACTTAGGTGGG	0.403000												
TNFAIP1	7126	broad.mit.edu	37	17	26667474	26667474	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr17:26667474G>A	uc002hax.1	+	3	364	c.345G>A	c.(343-345)GGG>GGA	p.G115G	TNFAIP1_uc002hay.2_Silent_p.G115G|TNFAIP1_uc010waf.1_Silent_p.G11G	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	115					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TCATCCAGGGGCTGGTGAATA	0.547000												
MED24	9862	broad.mit.edu	37	17	38191438	38191438	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr17:38191438C>T	uc002htt.2	-	6	804	c.491G>A	c.(490-492)CGC>CAC	p.R164H	MED24_uc010wes.1_Missense_Mutation_p.R5H|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.R189H|MED24_uc002htu.2_Missense_Mutation_p.R151H|MED24_uc010cwn.2_Missense_Mutation_p.R151H|MED24_uc010weu.1_Missense_Mutation_p.R74H|MED24_uc010wev.1_Missense_Mutation_p.R114H|MED24_uc010wew.1_Missense_Mutation_p.R93H|MED24_uc010wex.1_Intron|MED24_uc010wez.1_5'Flank|MED24_uc010wfa.1_Missense_Mutation_p.R114H|MED24_uc010wfb.1_Missense_Mutation_p.R176H|MED24_uc010wfc.1_Missense_Mutation_p.R101H	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	164					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TTTCTCCAGGCGCTGAAGGCA	0.657000											OREG0024387	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
KIF2B	84643	broad.mit.edu	37	17	51901901	51901901	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr17:51901901C>A	uc002iua.2	+	1	1663	c.1507C>A	c.(1507-1509)CTC>ATC	p.L503I	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	503					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CACACTGGTGCTCCGGGACTC	0.473000												
BCAS3	54828	broad.mit.edu	37	17	58885385	58885385	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr17:58885385T>G	uc002iyv.3	+	7	533	c.424T>G	c.(424-426)TTT>GTT	p.F142V	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Missense_Mutation_p.F142V|BCAS3_uc002iyw.3_Missense_Mutation_p.F138V	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	142						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			ATGTGATAACTTTGCTGAAAA	0.303000												
ABCA6	23460	broad.mit.edu	37	17	67087325	67087325	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr17:67087325G>C	uc002jhw.1	-	26	3662	c.3487C>G	c.(3487-3489)CCT>GCT	p.P1163A		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1163	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GTATATGAAGGAACCAATACC	0.323000												
SETBP1	26040	broad.mit.edu	37	18	42531308	42531308	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr18:42531308A>C	uc010dni.2	+	4	2299	c.2003A>C	c.(2002-2004)AAG>ACG	p.K668T		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	668						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		ACTATCAATAAGATGAAGACA	0.473000									Schinzel-Giedion_syndrome			
SALL3	27164	broad.mit.edu	37	18	76752229	76752229	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr18:76752229C>A	uc002lmt.2	+	2	238	c.238C>A	c.(238-240)CTG>ATG	p.L80M	SALL3_uc010dra.2_5'Flank	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCCGCCCGTGCTGATCGTGCA	0.716000												
GRIN3B	116444	broad.mit.edu	37	19	1005304	1005304	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:1005304G>A	uc002lqo.1	+	3	1804	c.1804G>A	c.(1804-1806)GGC>AGC	p.G602S		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	602	Cytoplasmic (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TAGCCCCTACGGCCTCACGCC	0.642000												
MUC16	94025	broad.mit.edu	37	19	9067492	9067492	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:9067492T>G	uc002mkp.2	-	3	20158	c.19954A>C	c.(19954-19956)ACA>CCA	p.T6652P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6654	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGGAGAATGTTGACTCCATC	0.507000												
JUNB	3726	broad.mit.edu	37	19	12903585	12903585	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:12903585A>T	uc002mvc.2	+	1	1276	c.1000A>T	c.(1000-1002)AAC>TAC	p.N334Y	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	334						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						CCACGTCAGCAACGGCTGTCA	0.657000												
FKBP8	23770	broad.mit.edu	37	19	18650400	18650400	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:18650400C>T	uc002njk.1	-	3	536	c.423G>A	c.(421-423)CCG>CCA	p.P141P	FKBP8_uc002nji.1_5'UTR|FKBP8_uc010xqi.1_Silent_p.P170P|FKBP8_uc002njj.1_Silent_p.P141P|FKBP8_uc002njl.1_Silent_p.P141P|FKBP8_uc002njm.1_Silent_p.P141P|FKBP8_uc010ebr.1_Intron|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	141	PPIase FKBP-type.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						ACACCAGCTCCGGCTCCTCCT	0.682000												
ZNF257	113835	broad.mit.edu	37	19	22271961	22271961	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:22271961A>T	uc010ecx.2	+	4	1578	c.1409A>T	c.(1408-1410)CAG>CTG	p.Q470L	ZNF257_uc010ecy.2_Missense_Mutation_p.Q438L	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	470	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				GCCTTTAACCAGTCTTCACAC	0.408000												
ZNF91	7644	broad.mit.edu	37	19	23544823	23544823	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:23544823T>C	uc002nre.2	-	4	1071	c.958A>G	c.(958-960)AAA>GAA	p.K320E	ZNF91_uc010xrj.1_Missense_Mutation_p.K288E	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	320						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTGTAGGGTTTCTCTCCAGTA	0.388000												
C19orf2	8725	broad.mit.edu	37	19	30503321	30503321	+	Silent	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:30503321A>T	uc002nsr.2	+	10	1338	c.1308A>T	c.(1306-1308)GGA>GGT	p.G436G	C19orf2_uc002nsq.2_Silent_p.G418G|C19orf2_uc002nss.2_Silent_p.G396G|C19orf2_uc002nst.2_Silent_p.G360G	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	436					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		ATAGGCGGGGAGTTTTGAGGA	0.458000												
APLP1	333	broad.mit.edu	37	19	36365445	36365445	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:36365445T>C	uc002oce.2	+	9	1234	c.1096T>C	c.(1096-1098)TCT>CCT	p.S366P	APLP1_uc010xsz.1_Missense_Mutation_p.S327P|APLP1_uc002ocf.2_Missense_Mutation_p.S366P|APLP1_uc002ocg.2_Missense_Mutation_p.S269P|APLP1_uc010xta.1_Missense_Mutation_p.S360P	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	366	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGAGCAGGTGTCTGGTGAGCG	0.632000												
SPRED3	399473	broad.mit.edu	37	19	38881012	38881012	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:38881012G>A	uc002oim.2	+	1	74	c.70G>A	c.(70-72)GGG>AGG	p.G24R	GGN_uc002oij.1_5'Flank|GGN_uc002oik.1_5'Flank|GGN_uc010efy.1_5'Flank|SPRED3_uc002oil.1_Missense_Mutation_p.G24R	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	24	WH1.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTGGGGGGCGGGGGCCTCAG	0.726000												
TBC1D17	79735	broad.mit.edu	37	19	50390983	50390983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:50390983G>A	uc002pqo.2	+	15	1703	c.1551G>A	c.(1549-1551)TGG>TGA	p.W517*	TBC1D17_uc010ybg.1_Nonsense_Mutation_p.W484*|TBC1D17_uc002pqp.2_Nonsense_Mutation_p.W168*|TBC1D17_uc002pqr.2_Nonsense_Mutation_p.W168*|TBC1D17_uc002pqs.2_RNA|IL4I1_uc002pqv.1_3'UTR|IL4I1_uc010eno.1_3'UTR|IL4I1_uc002pqw.1_3'UTR	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	517	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		AGGTGCTGTGGACAGGGCTCC	0.667000												
LENG9	94059	broad.mit.edu	37	19	54973371	54973371	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:54973371T>A	uc010yez.1	-	1	1524	c.1405A>T	c.(1405-1407)AGC>TGC	p.S469C		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	469					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		ACTTCCTGGCTGAGGGTGAAC	0.652000												
ZNF471	57573	broad.mit.edu	37	19	57036546	57036546	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:57036546T>C	uc002qnh.2	+	5	1243	c.1110T>C	c.(1108-1110)ACT>ACC	p.T370T		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		GTTATCATACTGGAGAGAAGC	0.398000												
USP29	57663	broad.mit.edu	37	19	57641380	57641380	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:57641380T>C	uc002qny.2	+	4	1693	c.1337T>C	c.(1336-1338)CTC>CCC	p.L446P		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	446					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATGCTGTTCTCAAGGTAGAA	0.383000												
ZNF135	7694	broad.mit.edu	37	19	58578734	58578734	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr19:58578734T>C	uc010yhq.1	+	5	1014	c.918T>C	c.(916-918)GGT>GGC	p.G306G	ZNF135_uc002qre.2_Silent_p.G294G|ZNF135_uc002qrd.1_Silent_p.G252G|ZNF135_uc002qrf.2_Silent_p.G252G|ZNF135_uc002qrg.2_Silent_p.G264G|ZNF135_uc010yhr.1_Silent_p.G115G	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	306					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CTCACACAGGTGAGAAGCCCT	0.512000												
APOB	338	broad.mit.edu	37	2	21234209	21234209	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:21234209G>A	uc002red.2	-	26	5659	c.5531C>T	c.(5530-5532)TCT>TTT	p.S1844F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1844					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAAGGCAGCAGAAGAGATGGC	0.468000												
EHBP1	23301	broad.mit.edu	37	2	63058193	63058193	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:63058193G>A	uc002sby.2	+	7	1016	c.534G>A	c.(532-534)ATG>ATA	p.M178I	EHBP1_uc010fcp.2_Missense_Mutation_p.M178I|EHBP1_uc002sbx.2_Missense_Mutation_p.M178I|EHBP1_uc002sbz.2_Missense_Mutation_p.M178I|EHBP1_uc002scb.2_Missense_Mutation_p.M178I	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	178						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TGATGAGTATGAAGCAGGCTG	0.343000									Hereditary_Prostate_Cancer			
CNRIP1	25927	broad.mit.edu	37	2	68544371	68544371	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:68544371A>C	uc002sek.3	-	2	899	c.248T>G	c.(247-249)GTT>GGT	p.V83G	CNRIP1_uc002sej.3_Missense_Mutation_p.V83G|CNRIP1_uc002sel.3_RNA|CNRIP1_uc010fdd.1_Missense_Mutation_p.V83G	NM_015463	NP_056278	Q96F85	CNRP1_HUMAN	cannabinoid receptor interacting protein 1	83							protein binding			liver(1)	1						CGTATAAACAACTCTGTCCCC	0.498000												
DYSF	8291	broad.mit.edu	37	2	71741005	71741005	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:71741005C>A	uc002sie.2	+	6	993	c.617C>A	c.(616-618)GCG>GAG	p.A206E	DYSF_uc010feg.2_Missense_Mutation_p.A237E|DYSF_uc010feh.2_Missense_Mutation_p.A206E|DYSF_uc002sig.3_Missense_Mutation_p.A206E|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.A206E|DYSF_uc010fef.2_Missense_Mutation_p.A237E|DYSF_uc010fei.2_Missense_Mutation_p.A237E|DYSF_uc010fek.2_Missense_Mutation_p.A238E|DYSF_uc010fej.2_Missense_Mutation_p.A207E|DYSF_uc010fel.2_Missense_Mutation_p.A207E|DYSF_uc010feo.2_Missense_Mutation_p.A238E|DYSF_uc010fem.2_Missense_Mutation_p.A207E|DYSF_uc010fen.2_Missense_Mutation_p.A238E|DYSF_uc002sif.2_Missense_Mutation_p.A207E	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	206	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						AAGCGAAGTGCGCCTACATCT	0.587000												
CNTNAP5	129684	broad.mit.edu	37	2	125262020	125262020	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:125262020T>C	uc002tno.2	+	8	1575	c.1211T>C	c.(1210-1212)CTT>CCT	p.L404P	CNTNAP5_uc010flu.2_Missense_Mutation_p.L405P	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	404	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GATGGTCTGCTTCTGTCCACA	0.552000												
FAM123C	205147	broad.mit.edu	37	2	131520539	131520539	+	Silent	SNP	C	C	T	rs140458255		TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:131520539C>T	uc002trw.2	+	2	1084	c.894C>T	c.(892-894)CCC>CCT	p.P298P	FAM123C_uc010fmv.2_Silent_p.P298P|FAM123C_uc010fms.1_Silent_p.P298P|FAM123C_uc010fmt.1_Silent_p.P298P|FAM123C_uc010fmu.1_Silent_p.P298P	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	298										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		TGGCCTCGCCCGCCCAGAATG	0.657000												
NCKAP5	344148	broad.mit.edu	37	2	133971302	133971302	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:133971302T>G	uc002ttp.2	-	5	567	c.193A>C	c.(193-195)AGT>CGT	p.S65R	NCKAP5_uc002ttq.2_Missense_Mutation_p.S65R|NCKAP5_uc002ttt.1_Missense_Mutation_p.S65R|NCKAP5_uc002tts.1_Missense_Mutation_p.S40R	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	65							protein binding				0						GCCCCCTCACTTGTTCTTTGG	0.488000												
LRP1B	53353	broad.mit.edu	37	2	141625304	141625304	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:141625304A>T	uc002tvj.1	-	27	5406	c.4434T>A	c.(4432-4434)TAT>TAA	p.Y1478*	LRP1B_uc010fnl.1_Nonsense_Mutation_p.Y660*	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1478	Extracellular (Potential).|LDL-receptor class B 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTCACTCCCATATAGAGACA	0.448000										TSP Lung(27;0.18)		
LRP1B	53353	broad.mit.edu	37	2	141665505	141665505	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:141665505T>C	uc002tvj.1	-	22	4433	c.3461A>G	c.(3460-3462)GAG>GGG	p.E1154G	LRP1B_uc010fnl.1_Missense_Mutation_p.E336G	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1154	Extracellular (Potential).|LDL-receptor class A 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCAGAGTTTCTCTGGCTGCAG	0.448000										TSP Lung(27;0.18)		
LRP1B	53353	broad.mit.edu	37	2	141747223	141747223	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:141747223T>G	uc002tvj.1	-	17	3620	c.2648A>C	c.(2647-2649)AAT>ACT	p.N883T	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	883	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAGCTATGATTGACTGGGAG	0.363000										TSP Lung(27;0.18)		
GALNT13	114805	broad.mit.edu	37	2	155102400	155102400	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:155102400T>C	uc002tyr.3	+	7	1329	c.762T>C	c.(760-762)ACT>ACC	p.T254T	GALNT13_uc002tyt.3_Silent_p.T254T|GALNT13_uc010foc.1_Silent_p.T73T|GALNT13_uc010fod.2_Silent_p.T7T	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	254	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CAGACATGACTTATGGGGGTT	0.408000												
XIRP2	129446	broad.mit.edu	37	2	167760333	167760333	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:167760333T>G	uc002udx.2	+	1	359	c.341T>G	c.(340-342)CTT>CGT	p.L114R	XIRP2_uc010fpn.2_Missense_Mutation_p.L114R|XIRP2_uc010fpo.2_Missense_Mutation_p.L114R|XIRP2_uc010fpp.2_Missense_Mutation_p.L114R	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCCATTGCCCTTGATGAGCTG	0.498000												
MYO3B	140469	broad.mit.edu	37	2	171258164	171258164	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:171258164C>T	uc002ufy.2	+	18	2235	c.2092C>T	c.(2092-2094)CGC>TGC	p.R698C	MYO3B_uc002ufv.2_Missense_Mutation_p.R685C|MYO3B_uc010fqb.1_Missense_Mutation_p.R685C|MYO3B_uc002ufz.2_Missense_Mutation_p.R698C|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	698	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GATTGTGAATCGCATTAATAC	0.547000												
TTN	7273	broad.mit.edu	37	2	179470170	179470170	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:179470170G>A	uc010zfg.1	-	228	46372	c.46148C>T	c.(46147-46149)CCT>CTT	p.P15383L	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P9078L|TTN_uc010zfi.1_Missense_Mutation_p.P9011L|TTN_uc010zfj.1_Missense_Mutation_p.P8886L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16310							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACATTAAGAGGTAGGGATGG	0.348000												
TTN	7273	broad.mit.edu	37	2	179614992	179614992	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:179614992T>G	uc002unb.2	-	46	12359	c.12135A>C	c.(12133-12135)AAA>AAC	p.K4045N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACTGGGACTTTATGTGCTT	0.393000												
TTN	7273	broad.mit.edu	37	2	179633583	179633583	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:179633583A>C	uc010zfg.1	-	38	9204	c.8980T>G	c.(8980-8982)TAT>GAT	p.Y2994D	TTN_uc010zfh.1_Missense_Mutation_p.Y2948D|TTN_uc010zfi.1_Missense_Mutation_p.Y2948D|TTN_uc010zfj.1_Missense_Mutation_p.Y2948D|TTN_uc002unb.2_Missense_Mutation_p.Y2994D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2994							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCCTTCATAGTTCACTGTC	0.378000												
STAT1	6772	broad.mit.edu	37	2	191848385	191848385	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:191848385G>A	uc002usj.2	-	17	1817	c.1429C>T	c.(1429-1431)CTG>TTG	p.L477L	STAT1_uc010fse.1_Silent_p.L477L|STAT1_uc002usk.2_Silent_p.L477L|STAT1_uc002usl.2_Silent_p.L479L|STAT1_uc010fsf.1_Silent_p.L289L	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	477					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TCCGCCACCAGCATGTTGTAC	0.547000												
PLCL1	5334	broad.mit.edu	37	2	198950584	198950584	+	Silent	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:198950584T>G	uc010fsp.2	+	2	2634	c.2343T>G	c.(2341-2343)ACT>ACG	p.T781T	PLCL1_uc002uuv.3_Silent_p.T702T	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	781	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TTGATGAAACTTTTGAGTTCC	0.388000												
PLCL1	5334	broad.mit.edu	37	2	198950764	198950764	+	Silent	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:198950764T>G	uc010fsp.2	+	2	2814	c.2523T>G	c.(2521-2523)CTT>CTG	p.L841L	PLCL1_uc002uuv.3_Silent_p.L762L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	841					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	ACGTAACCCTTTTTGTCCACA	0.453000												
SPATS2L	26010	broad.mit.edu	37	2	201305422	201305422	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:201305422C>G	uc002uvn.3	+	8	1055	c.703C>G	c.(703-705)CTA>GTA	p.L235V	SPATS2L_uc010fst.2_Missense_Mutation_p.L235V|SPATS2L_uc002uvo.3_Missense_Mutation_p.L175V|SPATS2L_uc002uvp.3_Missense_Mutation_p.L235V|SPATS2L_uc002uvq.3_Missense_Mutation_p.L166V|SPATS2L_uc002uvr.3_Missense_Mutation_p.L235V|SPATS2L_uc010zhc.1_Missense_Mutation_p.L265V	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	235						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						CACCGTTTCTCTAACTAGATA	0.373000												
RAPH1	65059	broad.mit.edu	37	2	204354397	204354397	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:204354397G>A	uc002vad.2	-	4	867	c.642C>T	c.(640-642)TCC>TCT	p.S214S	RAPH1_uc002vae.2_Silent_p.S214S|RAPH1_uc002vaf.2_Silent_p.S214S	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	214					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						TGGAGGCTGCGGAAGTGATGC	0.453000												
ZDBF2	57683	broad.mit.edu	37	2	207170797	207170797	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:207170797A>C	uc002vbp.2	+	5	1795	c.1545A>C	c.(1543-1545)GAA>GAC	p.E515D		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	515							nucleic acid binding|zinc ion binding			ovary(3)	3						CTGTAACAGAAGTAAACCTTC	0.418000												
MAP2	4133	broad.mit.edu	37	2	210557419	210557419	+	Silent	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:210557419A>C	uc002vde.1	+	7	773	c.525A>C	c.(523-525)TCA>TCC	p.S175S	MAP2_uc002vdc.1_Silent_p.S175S|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.S171S	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	175					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTGAGCCTTCAGACCAGAAGG	0.433000												
ABCA12	26154	broad.mit.edu	37	2	215812241	215812241	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:215812241A>C	uc002vew.2	-	48	7364	c.7144T>G	c.(7144-7146)TTC>GTC	p.F2382V	ABCA12_uc002vev.2_Missense_Mutation_p.F2064V|ABCA12_uc010zjn.1_Missense_Mutation_p.F1309V	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2382	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTGTCCTTGAAGGGCATCAGG	0.443000												
CHRND	1144	broad.mit.edu	37	2	233394675	233394675	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:233394675C>T	uc002vsw.2	+	7	650	c.646C>T	c.(646-648)CGG>TGG	p.R216W	CHRND_uc010zmg.1_Missense_Mutation_p.R201W|CHRND_uc010fyc.2_Missense_Mutation_p.R89W|CHRND_uc010zmh.1_Intron	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	216	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GATAGTCCACCGGCCGGCCAG	0.647000												
GPC1	2817	broad.mit.edu	37	2	241405692	241405692	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr2:241405692G>A	uc002vyw.3	+	9	1883	c.1662G>A	c.(1660-1662)AGG>AGA	p.R554R		NM_002081	NP_002072	P35052	GPC1_HUMAN	glypican 1 precursor	554					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		CAGTAGCCAGGCCCCGGTGGC	0.602000												
PLCB1	23236	broad.mit.edu	37	20	8626804	8626804	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:8626804C>T	uc002wnb.2	+	5	443	c.440C>T	c.(439-441)TCC>TTC	p.S147F	PLCB1_uc010zrb.1_Missense_Mutation_p.S46F|PLCB1_uc010gbv.1_Missense_Mutation_p.S147F|PLCB1_uc002wmz.1_Missense_Mutation_p.S147F|PLCB1_uc002wna.2_Missense_Mutation_p.S147F|PLCB1_uc002wnc.1_Missense_Mutation_p.S46F	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	147					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CAAAACATGTCCAGGGATGCA	0.408000												
C20orf26	26074	broad.mit.edu	37	20	20051611	20051611	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:20051611C>T	uc002wru.2	+	3	333	c.257C>T	c.(256-258)TCA>TTA	p.S86L	C20orf26_uc010gcw.1_Missense_Mutation_p.S40L|C20orf26_uc010zse.1_Missense_Mutation_p.S86L|C20orf26_uc010zsf.1_Missense_Mutation_p.S86L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	86										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GACTGGGTGTCAGTGTTCCGG	0.517000												
SSTR4	6754	broad.mit.edu	37	20	23016284	23016284	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:23016284C>T	uc002wsr.2	+	1	228	c.164C>T	c.(163-165)GCG>GTG	p.A55V		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	55	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGCATCTACGCGCTGGTGTGC	0.522000												
CD93	22918	broad.mit.edu	37	20	23065702	23065702	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:23065702G>A	uc002wsv.2	-	1	1276	c.1128C>T	c.(1126-1128)GGC>GGT	p.G376G		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	376	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CTCCAGGACCGCCCGGCTCAT	0.632000												
ACSS1	84532	broad.mit.edu	37	20	24993551	24993551	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:24993551G>A	uc002wub.2	-	11	2482	c.1604C>T	c.(1603-1605)GCT>GTT	p.A535V	ACSS1_uc002wuc.2_Missense_Mutation_p.A533V|ACSS1_uc010gdc.2_Missense_Mutation_p.A330V|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Missense_Mutation_p.A452V	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	535					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGTTCGGTAAGCCCCGTCTCC	0.577000												
C20orf4	25980	broad.mit.edu	37	20	34832708	34832708	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:34832708C>T	uc002xfc.1	+	3	940	c.847C>T	c.(847-849)CGG>TGG	p.R283W	C20orf4_uc002xfd.1_Missense_Mutation_p.R283W|C20orf4_uc002xfe.1_Missense_Mutation_p.R283W	NM_015511	NP_056326	Q9Y312	CT004_HUMAN	hypothetical protein LOC25980	283											0	Breast(12;0.0162)	Myeloproliferative disorder(115;0.0393)				CCTCCTGTGCCGGTCAGAAGC	0.532000												
ZFP64	55734	broad.mit.edu	37	20	50701472	50701472	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:50701472C>A	uc002xwk.2	-	9	1911	c.1562G>T	c.(1561-1563)CGT>CTT	p.R521L	ZFP64_uc002xwj.2_Missense_Mutation_p.R302L	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTTGAAGGGACGGTCCTTACA	0.642000												
RAE1	8480	broad.mit.edu	37	20	55931555	55931555	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:55931555G>C	uc002xyg.2	+	4	590	c.249G>C	c.(247-249)CAG>CAC	p.Q83H	RAE1_uc010gis.1_Missense_Mutation_p.Q36H|RAE1_uc010git.1_Missense_Mutation_p.Q83H|RAE1_uc002xyh.2_Missense_Mutation_p.Q83H|RAE1_uc002xyi.2_Missense_Mutation_p.Q83H	NM_003610	NP_003601	P78406	RAE1L_HUMAN	RAE1 (RNA export 1, S.pombe) homolog	83					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding				0	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			AAGCCCAGCAGATGCACACTG	0.418000												
TAF4	6874	broad.mit.edu	37	20	60584158	60584158	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr20:60584158G>A	uc002ybs.2	-	5	1834	c.1834C>T	c.(1834-1836)CAG>TAG	p.Q612*		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	612	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TCTGTAGACTGCTTGCCAGAT	0.378000												
TMPRSS15	5651	broad.mit.edu	37	21	19704431	19704431	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr21:19704431A>G	uc002ykw.2	-	14	1655	c.1624T>C	c.(1624-1626)TTT>CTT	p.F542L		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	542	Extracellular (Potential).|CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CTGTTTGGAAAGTTCGTAGAA	0.423000												
SLC5A4	6527	broad.mit.edu	37	22	32625330	32625330	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr22:32625330T>C	uc003ami.2	-	11	1133	c.1131A>G	c.(1129-1131)GGA>GGG	p.G377G		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	377	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						GGCCTCGCAGTCCTGGAGCCG	0.532000												
CBX6	23466	broad.mit.edu	37	22	39263079	39263079	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr22:39263079C>T	uc003awl.2	-	5	437	c.374G>A	c.(373-375)CGC>CAC	p.R125H		NM_014292	NP_055107	O95503	CBX6_HUMAN	chromobox homolog 6	125					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex					0	Melanoma(58;0.04)					ACGGTGGCAGCGGCGGATGTC	0.697000												
CELSR1	9620	broad.mit.edu	37	22	46805053	46805053	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr22:46805053G>A	uc003bhw.1	-	9	5066	c.5066C>T	c.(5065-5067)CCT>CTT	p.P1689L	CELSR1_uc011arc.1_Missense_Mutation_p.P2L	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1689	Extracellular (Potential).|Laminin G-like 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTGGGGGTGAGGCATGGCTGC	0.657000												
GRM7	2917	broad.mit.edu	37	3	7620685	7620685	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:7620685A>G	uc003bqm.2	+	8	2366	c.2092A>G	c.(2092-2094)AGC>GGC	p.S698G	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.S698G|GRM7_uc003bql.2_Missense_Mutation_p.S698G|GRM7_uc003bqn.1_Missense_Mutation_p.S281G|GRM7_uc010hch.1_Missense_Mutation_p.S209G	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	698	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CAGACTCATAAGCCCAACATC	0.433000												
SRGAP3	9901	broad.mit.edu	37	3	9027555	9027555	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:9027555G>A	uc003brf.1	-	22	3624	c.2948C>T	c.(2947-2949)ACG>ATG	p.T983M	SRGAP3_uc003brg.1_Missense_Mutation_p.T959M	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	983	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CTGCTTGACCGTGTTCTGCCT	0.642000			T	RAF1	pilocytic astrocytoma							
KCNH8	131096	broad.mit.edu	37	3	19554711	19554711	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:19554711A>C	uc003cbk.1	+	13	2524	c.2329A>C	c.(2329-2331)ACC>CCC	p.T777P	KCNH8_uc010hex.1_Missense_Mutation_p.T238P	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	777	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TTCCCCCAAAACCAAGCAGGA	0.468000												
DCLK3	85443	broad.mit.edu	37	3	36778860	36778861	+	Silent	DNP	GG	GG	AA			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:36778860_36778861GG>AA	uc003cgi.2	-	2	1781_1782	c.1290_1291CC>TT	c.(1288-1293)ATCCTG>ATTTTG	p.430_431IL>IL		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	430_431	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						ACGTACTCCAGGATCAGGTAGA	0.490000												
XYLB	9942	broad.mit.edu	37	3	38390119	38390119	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:38390119T>A	uc003cic.2	+	2	245	c.136T>A	c.(136-138)TTT>ATT	p.F46I	XYLB_uc011ayp.1_5'UTR	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	46					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TCTTCCAGAATTTGGGTATGT	0.438000												
MYRIP	25924	broad.mit.edu	37	3	40085715	40085715	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:40085715C>G	uc003cka.2	+	3	420	c.285C>G	c.(283-285)TAC>TAG	p.Y95*	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Nonsense_Mutation_p.Y95*|MYRIP_uc010hhw.2_Missense_Mutation_p.T52S|MYRIP_uc010hhx.1_Nonsense_Mutation_p.Y95*	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	95	FYVE-type.|RabBD.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GCTGCTCCTACCAGAAGCACG	0.552000												
ERC2	26059	broad.mit.edu	37	3	56207504	56207504	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:56207504C>T	uc003dhr.1	-	4	1375	c.1119G>A	c.(1117-1119)ACG>ACA	p.T373T		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	373	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GGAGAGCCTTCGTCTTGGCTG	0.488000												
CNTN3	5067	broad.mit.edu	37	3	74316425	74316425	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:74316425C>T	uc003dpm.1	-	20	2889	c.2809G>A	c.(2809-2811)GGA>AGA	p.G937R		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	937	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACTTTATATCCTGTTACTTCT	0.353000												
ROBO1	6091	broad.mit.edu	37	3	78700930	78700930	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:78700930G>A	uc003dqe.2	-	19	2972	c.2764C>T	c.(2764-2766)CGC>TGC	p.R922C	ROBO1_uc003dqb.2_Missense_Mutation_p.R883C|ROBO1_uc003dqc.2_Missense_Mutation_p.R886C|ROBO1_uc003dqd.2_Missense_Mutation_p.R886C|ROBO1_uc010hoh.2_Missense_Mutation_p.R114C|ROBO1_uc011bgl.1_Missense_Mutation_p.R494C	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	922	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTCTTCTTGCGGTGTCGATAA	0.433000												
HTR1F	3355	broad.mit.edu	37	3	88039930	88039930	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:88039930T>G	uc003dqr.2	+	2	189	c.31T>G	c.(31-33)TTG>GTG	p.L11V		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	11	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TGATCAAAACTTGACCTCAGA	0.368000												
HTR1F	3355	broad.mit.edu	37	3	88040909	88040909	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:88040909A>C	uc003dqr.2	+	2	1168	c.1010A>C	c.(1009-1011)TAT>TCT	p.Y337S		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	337	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TGGCTTGGGTATCTCAATTCC	0.313000												
IGSF11	152404	broad.mit.edu	37	3	118645003	118645003	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:118645003A>G	uc003ebw.2	-	4	772	c.525T>C	c.(523-525)ACT>ACC	p.T175T	IGSF11_uc011biv.1_Silent_p.T175T|IGSF11_uc003ebx.2_Silent_p.T175T|IGSF11_uc003eby.2_Silent_p.T174T|IGSF11_uc003ebz.2_Silent_p.T174T|IGSF11_uc010hqs.2_Silent_p.T174T	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	175	Ig-like C2-type.|Extracellular (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						CCCAAAGGTAAGTTGGTCGAG	0.478000												
POLQ	10721	broad.mit.edu	37	3	121151768	121151768	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:121151768A>G	uc003eee.3	-	29	7785	c.7656T>C	c.(7654-7656)GTT>GTC	p.V2552V	POLQ_uc003eed.2_Silent_p.V1724V	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2552					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAAATACCTGAACAACATCTT	0.438000								DNA_polymerases_(catalytic_subunits)				
PLXNA1	5361	broad.mit.edu	37	3	126751404	126751404	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:126751404C>T	uc003ejg.2	+	29	5341	c.5337C>T	c.(5335-5337)TAC>TAT	p.Y1779Y	PLXNA1_uc003ejh.2_Silent_p.Y447Y	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1802	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		AGCTGCTCTACGCCAAGGACA	0.642000												
KY	339855	broad.mit.edu	37	3	134338003	134338003	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:134338003C>T	uc010hty.2	-	8	759	c.697G>A	c.(697-699)GAG>AAG	p.E233K	KY_uc011blw.1_Missense_Mutation_p.E233K|KY_uc011blx.1_Missense_Mutation_p.E212K|KY_uc003eqr.1_5'UTR	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	233						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						CACATTCTCTCGAAGAGGCCA	0.577000												
PAQR9	344838	broad.mit.edu	37	3	142681901	142681901	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:142681901G>A	uc003evg.2	-	1	278	c.278C>T	c.(277-279)CCG>CTG	p.P93L	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	93	Helical; (Potential).					integral to membrane	receptor activity				0						CAGCAGCAGCGGGATGAAGTG	0.642000												
P2RY13	53829	broad.mit.edu	37	3	151046239	151046239	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:151046239C>G	uc003eyv.2	-	2	626	c.605G>C	c.(604-606)GGG>GCG	p.G202A	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	202	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			CCATTTCAGCCCCAGAGGCCC	0.383000												
GPR160	26996	broad.mit.edu	37	3	169802666	169802666	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:169802666A>C	uc003fgi.2	+	4	1496	c.906A>C	c.(904-906)AAA>AAC	p.K302N	GPR160_uc010hwq.2_Missense_Mutation_p.K302N	NM_014373	NP_055188	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	302	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTAATTTAAAAGACATTGGAT	0.328000												
NAALADL2	254827	broad.mit.edu	37	3	175520892	175520892	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:175520892A>G	uc003fit.2	+	14	2376	c.2289A>G	c.(2287-2289)CAA>CAG	p.Q763Q		NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	763	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AGACCCTTCAAGAAGCCCTGT	0.438000												
FGF12	2257	broad.mit.edu	37	3	191861866	191861866	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:191861866G>A	uc003fsx.2	-	5	1490	c.664C>T	c.(664-666)CGT>TGT	p.R222C	FGF12_uc003fsy.2_Missense_Mutation_p.R160C	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	222					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTCCTTGAACGCCCTTGTTTT	0.328000												
KIAA0226	9711	broad.mit.edu	37	3	197402382	197402382	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr3:197402382C>A	uc003fyc.2	-	19	2834	c.2651G>T	c.(2650-2652)TGC>TTC	p.C884F	KIAA0226_uc003fyd.3_Missense_Mutation_p.C839F|MIR922_hsa-mir-922|MI0005714_5'Flank	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	884	Cys-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TTTGGCTTGGCAGAGCTGGGG	0.542000												
ZNF595	152687	broad.mit.edu	37	4	87099	87099	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:87099T>C	uc003fzv.1	+	6	1861	c.1705T>C	c.(1705-1707)TGT>CGT	p.C569R	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.C337R|ZNF595_uc011but.1_Missense_Mutation_p.C337R	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	569					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		ATGCAAAGAATGTGGCAAAGC	0.393000												
OTOP1	133060	broad.mit.edu	37	4	4199804	4199804	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:4199804T>C	uc003ghp.1	-	5	787	c.757A>G	c.(757-759)AAC>GAC	p.N253D		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	253					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCGTGCAGTTACACTGCGGT	0.522000												
CD38	952	broad.mit.edu	37	4	15839770	15839770	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:15839770A>T	uc011bxc.1	+	5	748	c.641A>T	c.(640-642)AAA>ATA	p.K214I	CD38_uc003gol.1_Missense_Mutation_p.K214I	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	214	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						TCCCGCAGTAAAATCTTTGAC	0.368000												
KIAA1211	57482	broad.mit.edu	37	4	57182545	57182545	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:57182545A>T	uc003hbk.2	+	8	3268	c.2877A>T	c.(2875-2877)CAA>CAT	p.Q959H	KIAA1211_uc010iha.2_Missense_Mutation_p.Q952H|KIAA1211_uc011bzz.1_Missense_Mutation_p.Q869H|KIAA1211_uc003hbm.1_Missense_Mutation_p.Q845H	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	959	Pro-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CACTGGCACAAAAGCCAGCAC	0.637000												
TMPRSS11F	389208	broad.mit.edu	37	4	68956353	68956353	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:68956353T>G	uc003hdt.1	-	3	219	c.170A>C	c.(169-171)AAG>ACG	p.K57T		NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	57	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ATAGAAAGACTTATCATCTGA	0.333000												
C4orf31	79625	broad.mit.edu	37	4	121958019	121958019	+	Silent	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:121958019A>T	uc003idq.1	-	4	1634	c.1107T>A	c.(1105-1107)TCT>TCA	p.S369S		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	369											0						TTTGGTGAGAAGAGACTGGAG	0.413000												
FAT4	79633	broad.mit.edu	37	4	126372719	126372719	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:126372719A>C	uc003ifj.3	+	9	10548	c.10548A>C	c.(10546-10548)GAA>GAC	p.E3516D	FAT4_uc011cgp.1_Missense_Mutation_p.E1814D|FAT4_uc003ifi.1_Missense_Mutation_p.E994D	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3516	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTGAAGGAGAAGTCATGGAAA	0.478000												
FAT4	79633	broad.mit.edu	37	4	126411303	126411303	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:126411303G>T	uc003ifj.3	+	17	13326	c.13326G>T	c.(13324-13326)GAG>GAT	p.E4442D	FAT4_uc011cgp.1_Missense_Mutation_p.E2683D|FAT4_uc003ifi.1_Missense_Mutation_p.E1919D	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4442	EGF-like 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCAGCTGTGAGCCAGGCCTGC	0.612000												
OTUD4	54726	broad.mit.edu	37	4	146067479	146067479	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:146067479T>G	uc003ika.3	-	14	1305	c.1167A>C	c.(1165-1167)GAA>GAC	p.E389D	OTUD4_uc003ijz.3_Missense_Mutation_p.E388D	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	453							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AACGGGATTCTTCTATAGCTT	0.413000												
DCHS2	54798	broad.mit.edu	37	4	155219157	155219157	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:155219157G>A	uc003inw.2	-	18	4944	c.4944C>T	c.(4942-4944)TAC>TAT	p.Y1648Y		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1648	Cadherin 14.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGATAGGGAAGTATTCTGAAG	0.408000												
NPY2R	4887	broad.mit.edu	37	4	156135632	156135632	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:156135632A>C	uc003ioq.2	+	2	1036	c.541A>C	c.(541-543)AGT>CGT	p.S181R	NPY2R_uc003ior.2_Missense_Mutation_p.S181R	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	181	Helical; Name=4; (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CCTGCTGGCAAGTCCCCTGGC	0.552000												
TMEM192	201931	broad.mit.edu	37	4	166000876	166000876	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:166000876C>T	uc003iqz.3	-	6	849	c.750G>A	c.(748-750)GCG>GCA	p.A250A		NM_001100389	NP_001093859	Q8IY95	TM192_HUMAN	transmembrane protein 192	250	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|late endosome|lysosomal membrane|nucleus				skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0926)		TACTCAGCAGCGCATTGTGTC	0.453000												
TLL1	7092	broad.mit.edu	37	4	166935691	166935691	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr4:166935691A>G	uc003irh.1	+	8	1668	c.1021A>G	c.(1021-1023)AGA>GGA	p.R341G	TLL1_uc011cjn.1_Missense_Mutation_p.R341G|TLL1_uc011cjo.1_Missense_Mutation_p.R165G	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	341	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CGCACAGGCAAGAAAGCTGTA	0.448000												
BRD9	65980	broad.mit.edu	37	5	876276	876276	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:876276G>A	uc003jbq.2	-	12	1490	c.1323C>T	c.(1321-1323)GAC>GAT	p.D441D	BRD9_uc003jbl.2_Silent_p.D325D|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Silent_p.D388D|BRD9_uc003jbo.2_Silent_p.D345D|BRD9_uc003jbp.2_Silent_p.D102D|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	441							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			CCAGGAGGTCGTCCACCACTT	0.627000												
SEMA5A	9037	broad.mit.edu	37	5	9108375	9108375	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:9108375A>G	uc003jek.2	-	16	2662	c.1950T>C	c.(1948-1950)TGT>TGC	p.C650C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	650	TSP type-1 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TGTGTGGGGGACATAGCAAAT	0.512000												
DNAH5	1767	broad.mit.edu	37	5	13736033	13736033	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:13736033G>A	uc003jfd.2	-	67	11506	c.11464C>T	c.(11464-11466)CGG>TGG	p.R3822W	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3822					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATGCTGCCCCGCGTAGCCACT	0.443000									Kartagener_syndrome			
RXFP3	51289	broad.mit.edu	37	5	33937122	33937122	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:33937122G>A	uc003jic.1	+	1	634	c.277G>A	c.(277-279)GCC>ACC	p.A93T		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	93	Helical; Name=1; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GGTGGTGTGCGCCCTGGGGTT	0.662000												
CMYA5	202333	broad.mit.edu	37	5	79034410	79034410	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:79034410A>C	uc003kgc.2	+	2	9894	c.9822A>C	c.(9820-9822)CAA>CAC	p.Q3274H		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3274						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATTCATACCAACCGATAGCTG	0.438000												
DMXL1	1657	broad.mit.edu	37	5	118484496	118484496	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:118484496T>G	uc003ksd.2	+	18	3155	c.2974T>G	c.(2974-2976)TGT>GGT	p.C992G	DMXL1_uc010jcl.1_Missense_Mutation_p.C992G	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	992	WD 8.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GGCAACTTCATGTTCAGATGA	0.348000												
ACSL6	23305	broad.mit.edu	37	5	131324527	131324527	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:131324527G>A	uc010jdo.1	-	6	631	c.548C>T	c.(547-549)CCT>CTT	p.P183L	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.P208L|ACSL6_uc003kvy.1_Missense_Mutation_p.P208L|ACSL6_uc003kwb.2_Missense_Mutation_p.P173L|ACSL6_uc003kvz.1_Missense_Mutation_p.P148L|ACSL6_uc003kwa.1_Missense_Mutation_p.P194L|ACSL6_uc010jdn.1_Missense_Mutation_p.P183L|ACSL6_uc010jdp.1_5'Flank	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	183	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GATAGCCCCAGGGCCCAGGGT	0.602000												
PCDHGA2	56113	broad.mit.edu	37	5	140720706	140720706	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:140720706G>A	uc003ljk.1	+	1	2353	c.2168G>A	c.(2167-2169)CGC>CAC	p.R723H	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Missense_Mutation_p.R723H|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	723	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAAGTCACGCCTGCTGCAG	0.642000												
FAT2	2196	broad.mit.edu	37	5	150908750	150908750	+	Missense_Mutation	SNP	C	C	T	rs114070271	byFrequency	TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:150908750C>T	uc003lue.3	-	14	10028	c.10015G>A	c.(10015-10017)GTC>ATC	p.V3339I	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.V32I	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3339	Cadherin 30.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGAGGATGACGTCACCCACA	0.517000												
STC2	8614	broad.mit.edu	37	5	172750412	172750412	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:172750412C>T	uc003mco.1	-	3	1626	c.316G>A	c.(316-318)GCC>ACC	p.A106T	STC2_uc003mcn.1_Missense_Mutation_p.A21T	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	106					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CATTTCAAGGCGTCTTTGATG	0.567000												
FAF2	23197	broad.mit.edu	37	5	175916030	175916030	+	Splice_Site	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr5:175916030T>G	uc003mej.3	+	4	397	c.344_splice	c.e4+2	p.R115_splice		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8						response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						TATATTTAGGTATGTACCTTT	0.343000												
GFOD1	54438	broad.mit.edu	37	6	13365511	13365511	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:13365511G>A	uc003nat.1	-	2	1302	c.637C>T	c.(637-639)CGA>TGA	p.R213*	GFOD1_uc003nas.1_Nonsense_Mutation_p.R110*	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	213						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			GTGATCTGTCGGATGCCCTTG	0.592000												
ZNF311	282890	broad.mit.edu	37	6	28963505	28963505	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:28963505C>T	uc003nlu.2	-	7	1787	c.1274G>A	c.(1273-1275)AGT>AAT	p.S425N	ZNF311_uc011dlk.1_Missense_Mutation_p.S333N|ZNF311_uc003nlv.2_Missense_Mutation_p.S333N	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	425	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						TGAGCTCCGACTGAAGGCCCT	0.512000												
BRPF3	27154	broad.mit.edu	37	6	36181694	36181694	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:36181694C>T	uc003olv.3	+	8	2744	c.2520C>T	c.(2518-2520)CCC>CCT	p.P840P	BRPF3_uc010jwb.2_Intron|BRPF3_uc011dtj.1_Intron|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Intron	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	840					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCCTGGAGCCCACTGGGCCTG	0.493000												
C6orf138	442213	broad.mit.edu	37	6	47847330	47847330	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:47847330C>T	uc011dwm.1	-	3	1284	c.1199G>A	c.(1198-1200)CGC>CAC	p.R400H	C6orf138_uc011dwn.1_Missense_Mutation_p.R164H	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	417						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						CACAGGTTTGCGATCCAGGTA	0.507000												
LAMA2	3908	broad.mit.edu	37	6	129511389	129511389	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:129511389G>A	uc003qbn.2	+	11	1612	c.1507G>A	c.(1507-1509)GGC>AGC	p.G503S	LAMA2_uc003qbo.2_Missense_Mutation_p.G503S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	503	Laminin EGF-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTGCAAATCCGGCTTCTTCAA	0.433000												
TMEM200A	114801	broad.mit.edu	37	6	130762908	130762908	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:130762908A>C	uc003qca.2	+	3	2212	c.1341A>C	c.(1339-1341)CAA>CAC	p.Q447H	TMEM200A_uc010kfh.2_Missense_Mutation_p.Q447H|TMEM200A_uc010kfi.2_Missense_Mutation_p.Q447H|TMEM200A_uc003qcb.2_Missense_Mutation_p.Q447H	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	447	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TTGTGCCCCAAGTTGCCATCA	0.393000												
SYNE1	23345	broad.mit.edu	37	6	152718078	152718078	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:152718078A>T	uc010kiw.2	-	50	7990	c.7388T>A	c.(7387-7389)CTT>CAT	p.L2463H	SYNE1_uc003qot.3_Missense_Mutation_p.L2470H|SYNE1_uc003qou.3_Missense_Mutation_p.L2463H|SYNE1_uc010kjb.1_Missense_Mutation_p.L2446H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2463	Spectrin 4.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CACTGCATCAAGTTTGCTCTG	0.383000										HNSCC(10;0.0054)		
PLG	5340	broad.mit.edu	37	6	161158022	161158022	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:161158022A>G	uc003qtm.3	+	14	1848	c.1785A>G	c.(1783-1785)CAA>CAG	p.Q595Q		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	595	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGCCCTGGCAAGTCAGTCTTA	0.502000												
QKI	9444	broad.mit.edu	37	6	163984719	163984719	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr6:163984719T>G	uc003qui.2	+	6	1453	c.902T>G	c.(901-903)CTT>CGT	p.L301R	QKI_uc003que.2_Missense_Mutation_p.L301R|QKI_uc003quf.2_Missense_Mutation_p.L301R|QKI_uc003qug.2_Missense_Mutation_p.L301R|QKI_uc003quh.2_Missense_Mutation_p.L293R|QKI_uc003quj.2_Missense_Mutation_p.L293R	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	301					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		ACATCAATCCTTGAGTATCCT	0.433000												
TNRC18	84629	broad.mit.edu	37	7	5363972	5363972	+	Silent	SNP	C	C	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:5363972C>G	uc003soi.3	-	21	6664	c.6315G>C	c.(6313-6315)GGG>GGC	p.G2105G		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2105							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		TCACGGCACCCCCCTTGCCGC	0.622000												
DNAH11	8701	broad.mit.edu	37	7	21760426	21760426	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:21760426T>G	uc003svc.2	+	45	7270	c.7239T>G	c.(7237-7239)TTT>TTG	p.F2413L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2413					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AAGTCTATTTTGTATTTGCTT	0.393000									Kartagener_syndrome			
BMPER	168667	broad.mit.edu	37	7	34182850	34182850	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:34182850T>C	uc011kap.1	+	14	1868	c.1754T>C	c.(1753-1755)GTG>GCG	p.V585A		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	585					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AGGTCCTGTGTGACAGACATG	0.413000												
SFRP4	6424	broad.mit.edu	37	7	37955820	37955820	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:37955820T>C	uc003tfo.3	-	1	706	c.320A>G	c.(319-321)GAC>GGC	p.D107G		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	107	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GGGCTCGCAGTCGTCGCGCGC	0.617000												
C7orf10	79783	broad.mit.edu	37	7	40899936	40899936	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:40899936A>C	uc003thn.1	+	14	1220	c.1175A>C	c.(1174-1176)AAG>ACG	p.K392T	C7orf10_uc003thm.1_Missense_Mutation_p.K388T|C7orf10_uc003tho.1_Missense_Mutation_p.K344T|C7orf10_uc003thp.1_RNA	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	399							transferase activity			ovary(2)	2						AGATACAGTAAGTTCAAGATG	0.547000												
GLI3	2737	broad.mit.edu	37	7	42116369	42116369	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:42116369G>A	uc011kbh.1	-	4	546	c.455C>T	c.(454-456)CCG>CTG	p.P152L	GLI3_uc011kbg.1_Missense_Mutation_p.P93L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	152					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TGGAGGAATCGGAGATGGATC	0.428000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
ADCY1	107	broad.mit.edu	37	7	45753498	45753498	+	Silent	SNP	C	C	T	rs144524280		TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:45753498C>T	uc003tne.3	+	20	3282	c.3264C>T	c.(3262-3264)CCC>CCT	p.P1088P		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	1088	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GACGTCCCCCCGTGTGCCCCA	0.622000												
IKZF1	10320	broad.mit.edu	37	7	50459470	50459470	+	Silent	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:50459470G>T	uc003tow.3	+	8	927	c.759G>T	c.(757-759)CTG>CTT	p.L253L	IKZF1_uc003tox.3_Silent_p.L211L|IKZF1_uc003toy.3_Silent_p.L211L|IKZF1_uc011kck.1_Silent_p.L166L|IKZF1_uc003toz.3_Silent_p.L223L|IKZF1_uc010kyx.2_Intron|IKZF1_uc003tpa.3_Silent_p.L5L	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	253					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CAGAAGACCTGTGCAAGATAG	0.418000			D		ALL							
ZNF680	340252	broad.mit.edu	37	7	63982821	63982821	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:63982821A>T	uc003tta.2	-	4	484	c.311T>A	c.(310-312)TTT>TAT	p.F104Y	ZNF680_uc010kzr.2_Missense_Mutation_p.F31Y	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				CACTTTTTGAAAAGAATCTTT	0.328000												
ZNF680	340252	broad.mit.edu	37	7	63982823	63982823	+	Silent	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:63982823A>T	uc003tta.2	-	4	482	c.309T>A	c.(307-309)TCT>TCA	p.S103S	ZNF680_uc010kzr.2_Silent_p.S30S	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				CTTTTTGAAAAGAATCTTTTA	0.333000												
WBSCR17	64409	broad.mit.edu	37	7	70800597	70800597	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:70800597G>A	uc003tvy.2	+	2	300	c.300G>A	c.(298-300)CCG>CCA	p.P100P	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	100	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGGGCCTTCCGGCTACTCTTT	0.458000												
WBSCR17	64409	broad.mit.edu	37	7	71175770	71175770	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:71175770T>G	uc003tvy.2	+	10	1525	c.1525T>G	c.(1525-1527)TTC>GTC	p.F509V	WBSCR17_uc003tvz.2_Missense_Mutation_p.F208V	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	509	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CAAGGAAGGCTTCCTGCACTT	0.632000												
HGF	3082	broad.mit.edu	37	7	81355304	81355304	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:81355304G>T	uc003uhl.2	-	9	1235	c.1070C>A	c.(1069-1071)CCA>CAA	p.P357Q	HGF_uc003uhm.2_Missense_Mutation_p.P352Q	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	357	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						AGACCCATCTGGATTTCGGCA	0.428000												
PCLO	27445	broad.mit.edu	37	7	82585193	82585193	+	Nonsense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:82585193A>C	uc003uhx.2	-	5	5365	c.5076T>G	c.(5074-5076)TAT>TAG	p.Y1692*	PCLO_uc003uhv.2_Nonsense_Mutation_p.Y1692*	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1623					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTCGTCAAAATACAAACTTG	0.438000												
GRM3	2913	broad.mit.edu	37	7	86468784	86468784	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:86468784T>G	uc003uid.2	+	4	3053	c.1954T>G	c.(1954-1956)TTC>GTC	p.F652V	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.F524V|GRM3_uc010leh.2_Missense_Mutation_p.F244V	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	652	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGGGAGTTCCTTCGCTATCTG	0.527000												
ABCB1	5243	broad.mit.edu	37	7	87196226	87196226	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:87196226A>C	uc003uiz.1	-	7	823	c.405T>G	c.(403-405)TTT>TTG	p.F135L	ABCB1_uc011khc.1_Intron	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	135	ABC transmembrane type-1 1.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CCAGGCACCAAAATGAAACCT	0.423000												
TFPI2	7980	broad.mit.edu	37	7	93519622	93519622	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:93519622G>A	uc003umy.1	-	2	173	c.98C>T	c.(97-99)GCG>GTG	p.A33V	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Missense_Mutation_p.A33V|TFPI2_uc003una.1_Intron|TFPI2_uc003unb.1_Missense_Mutation_p.A33V|TFPI2_uc010lfg.1_Intron	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	33					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			ACAGATCTCCGCGTTATTTCC	0.572000												
ZKSCAN1	7586	broad.mit.edu	37	7	99631029	99631029	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:99631029T>G	uc003usk.1	+	6	1120	c.901T>G	c.(901-903)TTT>GTT	p.F301V	ZKSCAN1_uc003usl.1_Missense_Mutation_p.F265V|ZKSCAN1_uc003usm.1_Missense_Mutation_p.F88V	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	301					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CCAGAAAGAGTTTGGAGAGAA	0.483000												
RELN	5649	broad.mit.edu	37	7	103207203	103207203	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:103207203A>C	uc003vca.2	-	32	4752	c.4592T>G	c.(4591-4593)CTT>CGT	p.L1531R	RELN_uc010liz.2_Missense_Mutation_p.L1531R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1531					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGAACAATAAGCCCTGAGTT	0.408000												
RELN	5649	broad.mit.edu	37	7	103275919	103275919	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:103275919A>G	uc003vca.2	-	19	2578	c.2418T>C	c.(2416-2418)ACT>ACC	p.T806T	RELN_uc010liz.2_Silent_p.T806T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	806	BNR 2.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGAGTTTCCAAGTTATCCCAT	0.443000												
GPR85	54329	broad.mit.edu	37	7	112724143	112724143	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:112724143G>A	uc010ljv.2	-	2	1151	c.634C>T	c.(634-636)CGA>TGA	p.R212*	GPR85_uc003vgp.1_Nonsense_Mutation_p.R212*|GPR85_uc003vgq.2_Nonsense_Mutation_p.R212*|GPR85_uc010ljw.1_Nonsense_Mutation_p.R212*	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	212	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						ATTTTTCTTCGATCGTGGACG	0.493000												
PTPRZ1	5803	broad.mit.edu	37	7	121652018	121652018	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:121652018A>C	uc003vjy.2	+	12	3313	c.2918A>C	c.(2917-2919)AAG>ACG	p.K973T	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	973	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CCAATACCTAAGTCTTCGTTA	0.443000												
AASS	10157	broad.mit.edu	37	7	121717962	121717962	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:121717962G>A	uc003vka.2	-	22	2688	c.2592C>T	c.(2590-2592)ATC>ATT	p.I864I	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.I864I|AASS_uc011knw.1_Silent_p.I352I	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	864	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	AAAAGCCATTGATGTCCCCAT	0.433000												
TAS2R16	50833	broad.mit.edu	37	7	122635196	122635196	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:122635196T>C	uc003vkl.1	-	1	559	c.493A>G	c.(493-495)ACT>GCT	p.T165A		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	165	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						TCAGTTACAGTGCTGTTTCTT	0.403000												
CHRM2	1129	broad.mit.edu	37	7	136700570	136700570	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:136700570T>A	uc003vtf.1	+	4	1581	c.958T>A	c.(958-960)TCT>ACT	p.S320T	CHRM2_uc003vtg.1_Missense_Mutation_p.S320T|CHRM2_uc003vtj.1_Missense_Mutation_p.S320T|CHRM2_uc003vtk.1_Missense_Mutation_p.S320T|CHRM2_uc003vtl.1_Missense_Mutation_p.S320T|CHRM2_uc003vtm.1_Missense_Mutation_p.S320T|CHRM2_uc003vti.1_Missense_Mutation_p.S320T|CHRM2_uc003vto.1_Missense_Mutation_p.S320T|CHRM2_uc003vtn.1_Missense_Mutation_p.S320T|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	320	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	AGATGAGAACTCTAAGCAAAC	0.463000												
DGKI	9162	broad.mit.edu	37	7	137076050	137076050	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:137076050A>G	uc003vtt.2	-	34	3115	c.3114T>C	c.(3112-3114)GCT>GCC	p.A1038A	DGKI_uc003vtu.2_Silent_p.A707A	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	1038					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTGGGTCCCCAGCCTGCTGTG	0.463000												
CNTNAP2	26047	broad.mit.edu	37	7	146741127	146741127	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:146741127A>C	uc003weu.1	+	4	1047	c.531A>C	c.(529-531)GAA>GAC	p.E177D		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	177	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCAGAATTGAAGTTTATGGCT	0.378000										HNSCC(39;0.1)		
CNTNAP2	26047	broad.mit.edu	37	7	146997356	146997356	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:146997356A>C	uc003weu.1	+	9	1988	c.1472A>C	c.(1471-1473)AAA>ACA	p.K491T		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	491	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTTCAAGTTAAAACTGGCGAG	0.388000										HNSCC(39;0.1)		
CHPF2	54480	broad.mit.edu	37	7	150932222	150932222	+	Missense_Mutation	SNP	G	G	A	rs138209627		TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:150932222G>A	uc003wjr.1	+	2	1865	c.352G>A	c.(352-354)GTG>ATG	p.V118M	CHPF2_uc003wjq.1_Missense_Mutation_p.V110M	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	118	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						CACTTTGGCCGTGGCTGTGAA	0.627000												
UBE3C	9690	broad.mit.edu	37	7	157060400	157060400	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr7:157060400G>A	uc010lqs.2	+	23	3515	c.3203G>A	c.(3202-3204)AGT>AAT	p.S1068N	UBE3C_uc003wni.3_Missense_Mutation_p.S431N	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	1068	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CTTTTGCGAAGTAAACTTCTC	0.547000												
CSMD1	64478	broad.mit.edu	37	8	2806830	2806830	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:2806830C>G	uc011kwk.1	-	68	10786	c.10396G>C	c.(10396-10398)GAA>CAA	p.E3466Q	CSMD1_uc011kwj.1_Missense_Mutation_p.E2780Q|CSMD1_uc010lrg.2_Missense_Mutation_p.E1357Q	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3466	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTTGCCTTTCTAGCTTAAAT	0.343000												
CSMD1	64478	broad.mit.edu	37	8	2807839	2807839	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:2807839A>C	uc011kwk.1	-	67	10621	c.10231T>G	c.(10231-10233)TTA>GTA	p.L3411V	CSMD1_uc011kwj.1_Missense_Mutation_p.L2725V|CSMD1_uc010lrg.2_Missense_Mutation_p.L1302V	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3411	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCAGGAGTAAGTGGGCCTCC	0.398000												
BMP1	649	broad.mit.edu	37	8	22064885	22064885	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:22064885C>T	uc003xbg.2	+	18	2675	c.2431C>T	c.(2431-2433)CGA>TGA	p.R811*	BMP1_uc011kzc.1_Nonsense_Mutation_p.R560*|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	811	CUB 4.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GTTCGACGGGCGAGACGCCAA	0.612000												
ANK1	286	broad.mit.edu	37	8	41530411	41530411	+	Silent	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:41530411G>A	uc003xok.2	-	38	4641	c.4557C>T	c.(4555-4557)GAC>GAT	p.D1519D	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Silent_p.D1519D|ANK1_uc003xoj.2_Silent_p.D1519D|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Silent_p.D1560D	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1519	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACAGCAGCTCGTCCTGCAGTG	0.612000												
MYST3	7994	broad.mit.edu	37	8	41836209	41836209	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:41836209T>C	uc010lxb.2	-	7	1538	c.994A>G	c.(994-996)ACT>GCT	p.T332A	MYST3_uc010lxc.2_Missense_Mutation_p.T332A|MYST3_uc003xon.3_Missense_Mutation_p.T332A|MYST3_uc010lxd.2_Missense_Mutation_p.T332A	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	332	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			ATTGGATTAGTATAGCGCCGT	0.388000												
SNTG1	54212	broad.mit.edu	37	8	51465669	51465669	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:51465669T>G	uc010lxy.1	+	13	1111	c.740T>G	c.(739-741)CTC>CGC	p.L247R	SNTG1_uc003xqs.1_Missense_Mutation_p.L247R|SNTG1_uc010lxz.1_Missense_Mutation_p.L247R|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	247					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ATTCAGTGCCTCTCTGCTGAA	0.428000												
SOX17	64321	broad.mit.edu	37	8	55372478	55372478	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:55372478G>A	uc003xsb.3	+	2	1372	c.1168G>A	c.(1168-1170)GAC>AAC	p.D390N		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	390	Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			GAATCTCCCCGACAGCCACGG	0.607000												
PREX2	80243	broad.mit.edu	37	8	69005938	69005938	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:69005938T>C	uc003xxv.1	+	21	2376	c.2349T>C	c.(2347-2349)GCT>GCC	p.A783A	PREX2_uc003xxu.1_Silent_p.A783A|PREX2_uc011lez.1_Silent_p.A718A	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	783					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CAGGGGATGCTTTTGACTGTA	0.403000												
JPH1	56704	broad.mit.edu	37	8	75156979	75156979	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:75156979G>C	uc003yae.2	-	4	1730	c.1690C>G	c.(1690-1692)CCA>GCA	p.P564A	JPH1_uc003yaf.2_Missense_Mutation_p.P564A|JPH1_uc003yag.1_Missense_Mutation_p.P428A	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	564	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			ACGTCTACTGGAGGGTGCTGG	0.577000												
CRISPLD1	83690	broad.mit.edu	37	8	75941706	75941706	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:75941706A>G	uc003yan.2	+	14	1780	c.1405A>G	c.(1405-1407)AGA>GGA	p.R469G	CRISPLD1_uc011lfk.1_Missense_Mutation_p.R281G|CRISPLD1_uc011lfl.1_Missense_Mutation_p.R281G	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	469	LCCL 2.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			TGTGGACAAAAGAAAGACCTA	0.378000												
PGCP	10404	broad.mit.edu	37	8	97797433	97797433	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:97797433T>G	uc003yhw.2	+	2	474	c.308T>G	c.(307-309)GTT>GGT	p.V103G	PGCP_uc010mbe.2_Missense_Mutation_p.V103G	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	103					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					CTGGAGAAAGTTCACCTGGAG	0.498000												
UBR5	51366	broad.mit.edu	37	8	103327016	103327016	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:103327016C>T	uc003ykr.1	-	15	1883	c.1850G>A	c.(1849-1851)TGT>TAT	p.C617Y	UBR5_uc003yks.1_Missense_Mutation_p.C617Y	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	617					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGCATCACTACACGTGGATGC	0.418000												
ZFPM2	23414	broad.mit.edu	37	8	106800975	106800975	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:106800975G>A	uc003ymd.2	+	6	585	c.562G>A	c.(562-564)GCC>ACC	p.A188T	ZFPM2_uc011lhs.1_5'UTR	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	188					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AACTACGAAGGCCATCTCTGA	0.428000												
ANGPT1	284	broad.mit.edu	37	8	108334268	108334268	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:108334268A>G	uc003ymn.2	-	4	1132	c.664T>C	c.(664-666)TTG>CTG	p.L222L	ANGPT1_uc011lhv.1_Silent_p.L22L|ANGPT1_uc003ymo.2_Silent_p.L222L|ANGPT1_uc003ymp.3_Silent_p.L22L	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	222	Potential.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			CGAGTAACCAAGCCTTGAAGG	0.393000												
CSMD3	114788	broad.mit.edu	37	8	113585834	113585834	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:113585834G>T	uc003ynu.2	-	24	4097	c.3938C>A	c.(3937-3939)GCA>GAA	p.A1313E	CSMD3_uc003yns.2_Missense_Mutation_p.A585E|CSMD3_uc003ynt.2_Missense_Mutation_p.A1273E|CSMD3_uc011lhx.1_Missense_Mutation_p.A1209E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1313	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GCGCATAGATGCACCAGTAAA	0.338000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	114111188	114111188	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:114111188T>G	uc003ynu.2	-	5	873	c.714A>C	c.(712-714)GAA>GAC	p.E238D	CSMD3_uc003ynt.2_Missense_Mutation_p.E198D|CSMD3_uc011lhx.1_Missense_Mutation_p.E238D|CSMD3_uc010mcx.1_Missense_Mutation_p.E238D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	238	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACAAGCATCTTCAGCTGTTA	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
TRPS1	7227	broad.mit.edu	37	8	116632000	116632000	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:116632000T>G	uc003ynz.2	-	2	745	c.286A>C	c.(286-288)AAC>CAC	p.N96H	TRPS1_uc011lhy.1_Missense_Mutation_p.N100H|TRPS1_uc003yny.2_Missense_Mutation_p.N109H|TRPS1_uc010mcy.2_Missense_Mutation_p.N96H	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	96					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GAGGGAAAGTTTCCTCCCTTA	0.488000									Langer-Giedion_syndrome			
FAM91A1	157769	broad.mit.edu	37	8	124801870	124801870	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:124801870A>G	uc003yqv.2	+	15	1357	c.1296A>G	c.(1294-1296)GAA>GAG	p.E432E	FAM91A1_uc011lik.1_Silent_p.E432E|FAM91A1_uc011lil.1_Silent_p.E190E	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	432										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			GCACTGGTGAAGGAGAAGCAC	0.363000												
SCRIB	23513	broad.mit.edu	37	8	144891180	144891180	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:144891180C>A	uc003yzp.1	-	15	1721	c.1714G>T	c.(1714-1716)GCA>TCA	p.A572S	SCRIB_uc003yzo.1_Missense_Mutation_p.A572S	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	572	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GCGTCCTCTGCGAAATGCACC	0.652000												
IFNB1	3456	broad.mit.edu	37	9	21077392	21077392	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:21077392G>C	uc003zok.2	-	1	552	c.477C>G	c.(475-477)TAC>TAG	p.Y159*		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	159					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	CACAGTGACTGTACTCCTTGG	0.443000												
TAF1L	138474	broad.mit.edu	37	9	32633779	32633779	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:32633779C>T	uc003zrg.1	-	1	1889	c.1799G>A	c.(1798-1800)CGG>CAG	p.R600Q	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	600					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AAAGGTGCCCCGAAGACCCTG	0.488000												
RORB	6096	broad.mit.edu	37	9	77300519	77300519	+	Silent	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:77300519C>T	uc004aji.2	+	10	1447	c.1398C>T	c.(1396-1398)GCC>GCT	p.A466A	RORB_uc004ajh.2_Silent_p.A455A	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	466	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CTGACTGTGCCACCGGCTGCA	0.428000												
PRUNE2	158471	broad.mit.edu	37	9	79320386	79320386	+	Silent	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:79320386A>G	uc010mpk.2	-	8	6928	c.6804T>C	c.(6802-6804)GAT>GAC	p.D2268D	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2268					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GTGGATCACCATCAAACAAAG	0.463000												
ROD1	9991	broad.mit.edu	37	9	114997138	114997138	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:114997138G>A	uc004bfw.2	-	9	1113	c.926C>T	c.(925-927)GCT>GTT	p.A309V	ROD1_uc004bfv.2_Missense_Mutation_p.A315V|ROD1_uc004bfx.2_Missense_Mutation_p.A312V|ROD1_uc011lwu.1_Missense_Mutation_p.A281V|ROD1_uc004bfy.2_Missense_Mutation_p.A214V|ROD1_uc004bfz.2_Missense_Mutation_p.A281V	NM_005156	NP_005147	O95758	ROD1_HUMAN	ROD1 regulator of differentiation 1 isoform 1	309					anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1						GGCAAATCCAGCAGCCCCTGC	0.378000												
TLR4	7099	broad.mit.edu	37	9	120475898	120475898	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:120475898T>G	uc004bjz.2	+	3	1783	c.1492T>G	c.(1492-1494)TTG>GTG	p.L498V	TLR4_uc004bka.2_Missense_Mutation_p.L458V|TLR4_uc004bkb.2_Missense_Mutation_p.L298V	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	498	LRR 16.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GCTGAGAAACTTGACCTTCCT	0.448000												
DBC1	1620	broad.mit.edu	37	9	122075621	122075621	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:122075621A>C	uc004bkc.2	-	2	469	c.13T>G	c.(13-15)TTT>GTT	p.F5V	DBC1_uc004bkd.2_Missense_Mutation_p.F5V	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	5					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						AGCTCAACAAACCTCCAGTTC	0.418000												
BAT2L1	84726	broad.mit.edu	37	9	134305594	134305594	+	Silent	SNP	C	C	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:134305594C>G	uc004can.3	+	1	118	c.63C>G	c.(61-63)CTC>CTG	p.L21L	BAT2L1_uc004cam.1_Silent_p.L21L	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	21							protein binding				0						ACTCGACTCTCAGCCTGTTTG	0.453000												
C9orf9	11092	broad.mit.edu	37	9	135762799	135762799	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:135762799G>A	uc004cbx.1	+	3	299	c.188G>A	c.(187-189)CGG>CAG	p.R63Q	C9orf9_uc004cby.1_Missense_Mutation_p.R63Q|C9orf9_uc004cbz.1_Missense_Mutation_p.R63Q	NM_018956	NP_061829	Q96E40	CI009_HUMAN	Rsb-66 protein	63								p.?(1)			0				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		TCCACAGACCGGCGGGTTCTG	0.597000												
CARD9	64170	broad.mit.edu	37	9	139265018	139265018	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr9:139265018C>T	uc004chg.3	-	5	929	c.763G>A	c.(763-765)GCC>ACC	p.A255T	CARD9_uc011mdw.1_Missense_Mutation_p.A255T|CARD9_uc011mdx.1_Missense_Mutation_p.A151T	NM_052813	NP_434700	Q9H257	CARD9_HUMAN	caspase recruitment domain protein 9 isoform 1	255	Potential.				positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			pancreas(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		TGGAGCAGGGCCTTCTCCTGC	0.706000												
PQBP1	10084	broad.mit.edu	37	X	48759272	48759272	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:48759272A>G	uc004dle.2	+	4	434	c.245A>G	c.(244-246)AAC>AGC	p.N82S	PQBP1_uc004dlf.2_Missense_Mutation_p.N82S|PQBP1_uc004dlg.2_Missense_Mutation_p.N82S|PQBP1_uc004dld.2_RNA|PQBP1_uc004dlh.2_Missense_Mutation_p.N82S|PQBP1_uc004dli.2_Missense_Mutation_p.N82S|PQBP1_uc004dlj.1_Missense_Mutation_p.N82S|PQBP1_uc004dln.2_Missense_Mutation_p.N82S|PQBP1_uc010nih.2_RNA|PQBP1_uc010nii.2_Missense_Mutation_p.N40S|PQBP1_uc004dlk.2_Missense_Mutation_p.N82S|PQBP1_uc004dll.2_Missense_Mutation_p.N44S|PQBP1_uc004dlm.2_Missense_Mutation_p.N40S|PQBP1_uc010nij.2_Intron	NM_001032382	NP_001027554	O60828	PQBP1_HUMAN	polyglutamine binding protein 1	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|transcription coactivator activity			large_intestine(1)	1						CATGACCCCAACTCCGTGGTT	0.542000												
GSPT2	23708	broad.mit.edu	37	X	51487269	51487269	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:51487269A>G	uc004dpl.2	+	1	773	c.547A>G	c.(547-549)AAA>GAA	p.K183E		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	183					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					GATGGAGGAAAAAGAGGAAAT	0.478000												
MED12	9968	broad.mit.edu	37	X	70360572	70360572	+	Silent	SNP	A	A	T			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:70360572A>T	uc004dyy.2	+	42	6331	c.6132A>T	c.(6130-6132)TCA>TCT	p.S2044S	MED12_uc004dyz.2_Silent_p.S2043S|MED12_uc004dza.2_Silent_p.S1894S|MED12_uc010nla.2_Silent_p.S673S	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	2044	Gln-rich.|Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GCGTCCGTTCAACAGCCATCC	0.313000												
MAGEE2	139599	broad.mit.edu	37	X	75004270	75004270	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:75004270A>G	uc004ecj.1	-	1	802	c.617T>C	c.(616-618)GTT>GCT	p.V206A		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	206	MAGE 1.									ovary(1)|skin(1)	2						CCACATATCAACTTTTAGCAG	0.498000												
KLHL4	56062	broad.mit.edu	37	X	86877393	86877393	+	Silent	SNP	T	T	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:86877393T>C	uc004efb.2	+	5	1289	c.1107T>C	c.(1105-1107)TCT>TCC	p.S369S	KLHL4_uc004efa.2_Silent_p.S369S	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	369						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TGCTGCTTTCTTACATCAGAC	0.413000												
GPRASP2	114928	broad.mit.edu	37	X	101970603	101970603	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:101970603G>C	uc004ejk.2	+	4	2140	c.806G>C	c.(805-807)AGG>ACG	p.R269T	GPRASP2_uc004ejl.2_Missense_Mutation_p.R269T|GPRASP2_uc004ejm.2_Missense_Mutation_p.R269T|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	269						cytoplasm	protein binding			ovary(1)	1						CCCAGGTCCAGGCCCAGATCC	0.507000												
SERPINA7	6906	broad.mit.edu	37	X	105281009	105281009	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:105281009A>C	uc004eme.1	-	1	57	c.41T>G	c.(40-42)CTT>CGT	p.L14R	SERPINA7_uc010npd.2_Missense_Mutation_p.L14R|SERPINA7_uc010npe.1_Missense_Mutation_p.L14R	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	14					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGTAGCATGAAGCCCAAGTAC	0.438000												
RGAG1	57529	broad.mit.edu	37	X	109696914	109696914	+	Silent	SNP	T	T	G			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:109696914T>G	uc004eor.1	+	3	3315	c.3069T>G	c.(3067-3069)GCT>GCG	p.A1023A	RGAG1_uc011msr.1_Silent_p.A1023A	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1023										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GAGCCTCTGCTTCTGGAGCAA	0.498000												
ACTRT1	139741	broad.mit.edu	37	X	127185305	127185305	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chrX:127185305A>C	uc004eum.2	-	1	1078	c.881T>G	c.(880-882)CTT>CGT	p.L294R		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	294						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GTCTGCATAAAGTTTATTCTG	0.522000												
RIMS2	9699	broad.mit.edu	37	8	105263942	105263942	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr8:105263941_105263941CT>C	uc003yls.3	+	27	4238	c.3997_3997CT>C	c.(3997-3999)cttfs	p.L1333fs	RIMS2_uc003ylp.3_Frame_Shift_Del_p.L1315fs|RIMS2_uc003ylq.3_Frame_Shift_Del_p.L1129fs|RIMS2_uc003ylr.3_Frame_Shift_Del_p.L1154fs	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	Homo sapiens regulating synaptic membrane exocytosis 2 (RIMS2), transcript variant 2, mRNA.	1377	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	Rab GTPase binding|metal ion binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATGGTTCAAACTTTTCCCACC	0.463										HNSCC(12;0.0054)		
FADS3	3995	broad.mit.edu	37	11	61643386	61643387	+	In_Frame_Ins	INS	-	-	CACAGC			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr11:61643385_61643386A>ACACAGC	uc001nsm.3	-	10	1376_1377	c.1223_1224T>GCTGTGT	c.(1222-1224)tgt>tGCTGTGT	p.408_408C>CC		NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	Homo sapiens fatty acid desaturase 3 (FADS3), mRNA.	408					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CGTGCTTGGCACACAGCGACTT	0.649												
DCT	1638	broad.mit.edu	37	13	95121040	95121041	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-8297-01A-12D-2340-08	TCGA-BR-8297-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	722132ab-435b-4269-ac2b-ff9c6ca573ca	d576b3d8-afd5-4475-ac9b-b23933dc84bc	g.chr13:95121039_95121040C>CA	uc010afh.3	-	1	982_983	c.555_556G>TG	c.(553-558)tttgtgfs	p.F185fs	DCT_uc001vlv.4_Frame_Shift_Ins_p.F185fs	NM_001129889	NP_001123361	P40126	TYRP2_HUMAN	Homo sapiens dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (DCT), transcript variant 2, mRNA.	185					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TGGAGCCACACAAAAAAATCAT	0.450												
