Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
DNAJC11	55735	broad.mit.edu	37	1	6712953	6712953	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:6712953C>A	uc001aof.2	-	6	672	c.566G>T	c.(565-567)GGA>GTA	p.G189V	DNAJC11_uc010nzt.1_Missense_Mutation_p.G151V|DNAJC11_uc001aog.2_Missense_Mutation_p.G189V|DNAJC11_uc010nzu.1_Missense_Mutation_p.G99V	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	189					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTCCATTTCCATTCTGGGT	0.463000												
SPEN	23013	broad.mit.edu	37	1	16260713	16260713	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:16260713G>A	uc001axk.1	+	11	8182	c.7978G>A	c.(7978-7980)GTC>ATC	p.V2660I	SPEN_uc010obp.1_Missense_Mutation_p.V2619I	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2660	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTGGTGAACGTCTCCCTGGT	0.562000												
TXLNA	200081	broad.mit.edu	37	1	32660744	32660744	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:32660744C>T	uc001bui.2	+	11	1654	c.1589C>T	c.(1588-1590)ACA>ATA	p.T530I	TXLNA_uc001buj.2_Missense_Mutation_p.T530I	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin	530				T -> A (in Ref. 2; CAD91138).	cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCACCGAGCACAGAAGCATCA	0.667000												
SEMA6C	10500	broad.mit.edu	37	1	151110229	151110229	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:151110229G>T	uc001ewu.2	-	10	1014	c.714C>A	c.(712-714)TTC>TTA	p.F238L	SEMA6C_uc001ewv.2_Missense_Mutation_p.F238L|SEMA6C_uc001eww.2_Missense_Mutation_p.F198L|SEMA6C_uc010pcq.1_Missense_Mutation_p.F238L|SEMA6C_uc009wml.1_RNA	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	238	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGCGGAAGAAGAAGTAGACAT	0.557000												
ISG20L2	81875	broad.mit.edu	37	1	156696911	156696911	+	Silent	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:156696911C>T	uc001fps.1	-	1	795	c.534G>A	c.(532-534)AAG>AAA	p.K178K	ISG20L2_uc001fpt.1_Silent_p.K178K|C1orf66_uc001fpu.2_5'Flank|C1orf66_uc001fpv.2_5'Flank	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	178	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTGCCACCATCTTCCGTGGCA	0.493000											OREG0013885	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
ARHGAP30	257106	broad.mit.edu	37	1	161023088	161023088	+	Silent	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:161023088G>A	uc001fxl.2	-	6	970	c.624C>T	c.(622-624)CTC>CTT	p.L208L	ARHGAP30_uc001fxk.2_Silent_p.L208L|ARHGAP30_uc001fxm.2_Silent_p.L54L|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_Silent_p.L54L	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	208	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CCACGTGTGTGAGGATGAACT	0.557000												
TDRD5	163589	broad.mit.edu	37	1	179631422	179631422	+	Splice_Site	SNP	G	G	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:179631422G>T	uc001gnf.1	+	14	2593	c.2343_splice	c.e14+1	p.K781_splice	TDRD5_uc010pnp.1_Splice_Site_p.K835_splice|TDRD5_uc001gnh.1_Splice_Site_p.K336_splice	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5						DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GCCACAGAAGGTTAGATCCTT	0.269000												
KIF21B	23046	broad.mit.edu	37	1	200969033	200969033	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:200969033G>A	uc001gvs.1	-	12	2062	c.1745C>T	c.(1744-1746)ACG>ATG	p.T582M	KIF21B_uc001gvr.1_Missense_Mutation_p.T582M|KIF21B_uc009wzl.1_Missense_Mutation_p.T582M|KIF21B_uc010ppn.1_Missense_Mutation_p.T582M	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	582	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GTTCTCATCCGTCTCCTCGCT	0.627000												
RYR2	6262	broad.mit.edu	37	1	237617837	237617837	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:237617837G>T	uc001hyl.1	+	15	1559	c.1439G>T	c.(1438-1440)CGA>CTA	p.R480L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	480	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACAGACTACGAGCCCTGAAG	0.443000												
RYR2	6262	broad.mit.edu	37	1	237765353	237765353	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr1:237765353C>T	uc001hyl.1	+	35	4745	c.4625C>T	c.(4624-4626)GCG>GTG	p.A1542V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1542	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTATTTCCTGCGGTTTTTGCA	0.299000												
JMJD1C	221037	broad.mit.edu	37	10	64958456	64958456	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr10:64958456T>C	uc001jmn.2	-	12	5608	c.5308A>G	c.(5308-5310)ATA>GTA	p.I1770V	JMJD1C_uc001jml.2_Missense_Mutation_p.I1551V|JMJD1C_uc001jmm.2_Missense_Mutation_p.I1482V|JMJD1C_uc010qiq.1_Missense_Mutation_p.I1588V|JMJD1C_uc009xpi.2_Missense_Mutation_p.I1588V|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Intron	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1770					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AAACCATCTATTCTAACTACT	0.303000												
IFIT2	3433	broad.mit.edu	37	10	91066746	91066746	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr10:91066746G>A	uc009xts.2	+	2	1208	c.1033G>A	c.(1033-1035)GCT>ACT	p.A345T	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	345	TPR 5.				negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				CAGCCTCCATGCTCTAGCAGA	0.458000												
AFAP1L2	84632	broad.mit.edu	37	10	116061162	116061162	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr10:116061162C>T	uc001lbn.2	-	13	1794	c.1493G>A	c.(1492-1494)CGC>CAC	p.R498H	AFAP1L2_uc001lbo.2_Missense_Mutation_p.R498H|AFAP1L2_uc010qse.1_Missense_Mutation_p.R551H|AFAP1L2_uc001lbp.2_Missense_Mutation_p.R526H|AFAP1L2_uc001lbr.1_Missense_Mutation_p.R498H|AFAP1L2_uc001lbm.2_Missense_Mutation_p.R20H|AFAP1L2_uc010qsd.1_Missense_Mutation_p.R64H|AFAP1L2_uc001lbq.1_Missense_Mutation_p.R20H	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	498					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		CTCCTCCTGGCGGTCCTGGCT	0.617000												
SSRP1	6749	broad.mit.edu	37	11	57100226	57100226	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr11:57100226T>C	uc001njt.2	-	6	908	c.641A>G	c.(640-642)TAT>TGT	p.Y214C	SSRP1_uc010rjq.1_Missense_Mutation_p.Y214C	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	214					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						CCGAATGTCATAACGACCACG	0.522000												
DDB1	1642	broad.mit.edu	37	11	61076454	61076454	+	Splice_Site	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr11:61076454C>T	uc001nrc.3	-	21	2887	c.2661_splice	c.e21+1	p.T887_splice	DDB1_uc010rle.1_Splice_Site_p.T198_splice|DDB1_uc010rlf.1_Splice_Site_p.T887_splice	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1						cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CCAGGCCTCACCGTGCTATTG	0.502000								NER				
CCDC87	55231	broad.mit.edu	37	11	66360392	66360392	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr11:66360392G>A	uc001oiq.3	-	1	163	c.95C>T	c.(94-96)CCA>CTA	p.P32L	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	32										ovary(1)|skin(1)	2						CTGAGGCTCTGGGGACGTCGT	0.672000											OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
MMP27	64066	broad.mit.edu	37	11	102575437	102575437	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr11:102575437G>A	uc001phd.1	-	2	195	c.172C>T	c.(172-174)CTC>TTC	p.L58F		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	58					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TCATCTATGAGACTCCTATTC	0.378000												
ATM	472	broad.mit.edu	37	11	108205742	108205742	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr11:108205742T>G	uc001pkb.1	+	55	8442	c.8057T>G	c.(8056-8058)TTT>TGT	p.F2686C	ATM_uc009yxr.1_Missense_Mutation_p.F2686C|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.F1338C	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2686					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATACAGTCATTTAAAGCAGAA	0.373000			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)		
KDM5A	5927	broad.mit.edu	37	12	427605	427605	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:427605T>A	uc001qif.1	-	19	2927	c.2564A>T	c.(2563-2565)GAG>GTG	p.E855V	KDM5A_uc001qie.1_Missense_Mutation_p.E855V|KDM5A_uc010sdn.1_Missense_Mutation_p.E814V	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	855					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TTCATGAAACTCTTCCACATC	0.368000			T 	NUP98	AML							
KCNA6	3742	broad.mit.edu	37	12	4920527	4920527	+	Silent	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:4920527G>A	uc001qng.2	+	1	2186	c.1320G>A	c.(1318-1320)TCG>TCA	p.S440S		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	440	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						TCGTGGGCTCGCTGTGTGCCA	0.602000										HNSCC(72;0.22)		
LEPREL2	10536	broad.mit.edu	37	12	6948180	6948180	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:6948180G>A	uc001qra.1	+	16	1956	c.1922G>A	c.(1921-1923)CGC>CAC	p.R641H	LEPREL2_uc001qqz.1_Missense_Mutation_p.R448H|LEPREL2_uc001qrb.1_Missense_Mutation_p.R448H|GNB3_uc001qrc.2_5'Flank|GNB3_uc001qrd.2_5'Flank|GNB3_uc009zfe.2_5'Flank	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	641	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GTGCGTCCTCGCTGTGGGCGC	0.657000												
ENDOU	8909	broad.mit.edu	37	12	48105513	48105513	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:48105513C>T	uc001rpu.1	-	9	1172	c.1018G>A	c.(1018-1020)GGC>AGC	p.G340S	ENDOU_uc010sll.1_Intron|ENDOU_uc001rpt.1_Missense_Mutation_p.G299S|ENDOU_uc010slm.1_Missense_Mutation_p.G277S	NM_006025	NP_006016	P21128	ENDOU_HUMAN	placental protein 11 precursor	340					female pregnancy|immune response|proteolysis	cytoplasm|extracellular space|plasma membrane	endoribonuclease activity|growth factor activity|manganese ion binding|polysaccharide binding|RNA binding|scavenger receptor activity|serine-type peptidase activity			ovary(2)|pancreas(1)	3						TTATAGTAGCCGTCCCAGTTG	0.547000												
OR6C1	390321	broad.mit.edu	37	12	55715045	55715045	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:55715045G>A	uc010spi.1	+	1	662	c.662G>A	c.(661-663)AGA>AAA	p.R221K		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TACATTATCAGAACAATTTTG	0.383000												
LRP1	4035	broad.mit.edu	37	12	57591339	57591339	+	Silent	SNP	C	C	T	rs138786816		TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:57591339C>T	uc001snd.2	+	58	9640	c.9174C>T	c.(9172-9174)AAC>AAT	p.N3058N		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3058	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCCTGAACAACGCCGTTGCCT	0.557000												
SLC5A8	160728	broad.mit.edu	37	12	101603479	101603479	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:101603479G>A	uc001thz.3	-	1	538	c.148C>T	c.(148-150)CGC>TGC	p.R50C		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	50	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GTCATTCTGCGGCCGCCCATC	0.662000												
NAA25	80018	broad.mit.edu	37	12	112528652	112528652	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:112528652C>A	uc001ttm.2	-	3	181	c.161G>T	c.(160-162)GGT>GTT	p.G54V	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.G26V|NAA25_uc009zwa.1_Missense_Mutation_p.G54V	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	54	TPR 2.					cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TCTCTGTAAACCAATTGCCTT	0.408000												
P2RX4	5025	broad.mit.edu	37	12	121659754	121659754	+	Silent	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr12:121659754C>T	uc001tzr.2	+	3	625	c.321C>T	c.(319-321)CTC>CTT	p.L107L	P2RX4_uc010szr.1_RNA|P2RX4_uc010szs.1_Intron|P2RX4_uc009zxc.2_Silent_p.L107L|P2RX4_uc001tzs.2_Silent_p.L123L|P2RX4_uc009zxb.2_RNA|P2RX4_uc010szt.1_Silent_p.L6L	NM_002560	NP_002551	Q99571	P2RX4_HUMAN	purinergic receptor P2X4	107	Extracellular (Potential).				endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACGTGATCCTCACCATGAACC	0.637000												
RBM26	64062	broad.mit.edu	37	13	79911413	79911413	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr13:79911413A>G	uc001vkz.2	-	19	2577	c.2563T>C	c.(2563-2565)TCT>CCT	p.S855P	RBM26_uc001vky.2_Missense_Mutation_p.S826P|RBM26_uc001vla.2_Missense_Mutation_p.S829P|RBM26_uc010tia.1_Missense_Mutation_p.S210P|RBM26_uc001vkx.2_Missense_Mutation_p.S565P	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	853					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CCCCGACCAGATGAAAGAATC	0.532000												
SDR39U1	56948	broad.mit.edu	37	14	24912008	24912008	+	Splice_Site	SNP	T	T	C	rs17184766	by1000genomes	TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr14:24912008T>C	uc001wpm.2	-	1	1	c.-31_splice	c.e1-1		SDR39U1_uc001wpi.2_5'Flank|SDR39U1_uc001wpj.2_5'Flank|SDR39U1_uc001wpk.2_5'Flank|SDR39U1_uc001wpl.2_5'Flank|SDR39U1_uc001wpn.2_Intron|uc001wpo.1_5'Flank	NM_020195	NP_064580	Q9NRG7	D39U1_HUMAN	short chain dehydrogenase/reductase family 39U,								binding			pancreas(1)	1						TGCGTAAAGTTTAGAGTTTAC	0.582000												
KLHDC1	122773	broad.mit.edu	37	14	50206898	50206898	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr14:50206898A>G	uc001www.2	+	11	1007	c.979A>G	c.(979-981)ACA>GCA	p.T327A	SDCCAG1_uc010anj.1_Intron|KLHDC1_uc010tqg.1_Missense_Mutation_p.T282A|KLHDC1_uc010tqh.1_Missense_Mutation_p.T242A	NM_172193	NP_751943	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	327	Kelch 6.					cytoplasm				pancreas(1)	1	all_epithelial(31;0.00244)|Breast(41;0.00964)					TGCCTTGGATACAGTAAGAAA	0.323000												
SCAMP2	10066	broad.mit.edu	37	15	75137840	75137840	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr15:75137840C>T	uc002azb.1	-	8	903	c.829G>A	c.(829-831)GTG>ATG	p.V277M	ULK3_uc010ulp.1_5'Flank|ULK3_uc010ulq.1_5'Flank|ULK3_uc010ulr.1_5'Flank|ULK3_uc010bkf.1_5'Flank|ULK3_uc002ayv.2_5'Flank|ULK3_uc010uls.1_5'Flank|ULK3_uc010ult.1_5'Flank|ULK3_uc010ulu.1_5'Flank|SCAMP2_uc002aza.1_Missense_Mutation_p.V127M|SCAMP2_uc010bkg.1_RNA	NM_005697	NP_005688	O15127	SCAM2_HUMAN	secretory carrier membrane protein 2	277	Helical; (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						ACTGAGAGCACGGCACAGAGG	0.562000												
LINGO1	84894	broad.mit.edu	37	15	77906417	77906417	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr15:77906417G>A	uc002bct.1	-	2	1884	c.1832C>T	c.(1831-1833)GCG>GTG	p.A611V	LINGO1_uc002bcu.1_Missense_Mutation_p.A605V	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	611	Cytoplasmic (Potential).				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						CTTGCGGGGCGCGTCGGCGGA	0.483000												
ZNF710	374655	broad.mit.edu	37	15	90610422	90610422	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr15:90610422C>T	uc002bov.1	+	2	176	c.53C>T	c.(52-54)TCC>TTC	p.S18F		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GTGGTGCTGTCCTTGGCTCAG	0.632000												
ST8SIA2	8128	broad.mit.edu	37	15	92977597	92977597	+	Silent	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr15:92977597G>A	uc002bra.2	+	3	437	c.282G>A	c.(280-282)CTG>CTA	p.L94L	ST8SIA2_uc002brb.2_Silent_p.L73L	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	94	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CGCTCTCTCTGAGGATCAGGT	0.468000												
CACNA1H	8912	broad.mit.edu	37	16	1260449	1260449	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr16:1260449G>A	uc002cks.2	+	19	4173	c.3925G>A	c.(3925-3927)GTC>ATC	p.V1309I	CACNA1H_uc002ckt.2_Missense_Mutation_p.V1309I|CACNA1H_uc002cku.2_Missense_Mutation_p.V15I|CACNA1H_uc010brj.2_Missense_Mutation_p.V15I|CACNA1H_uc002ckv.2_Missense_Mutation_p.V15I	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1309	III.|Helical; Name=S1 of repeat III; (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCTCAACTGCGTCACCATCGC	0.637000												
KIAA0430	9665	broad.mit.edu	37	16	15718973	15718973	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr16:15718973G>A	uc002ddr.2	-	9	2204	c.2011C>T	c.(2011-2013)CAC>TAC	p.H671Y	KIAA0430_uc002ddq.2_Missense_Mutation_p.H527Y|KIAA0430_uc010uzv.1_Missense_Mutation_p.H667Y|KIAA0430_uc010uzw.1_Missense_Mutation_p.H669Y	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	670						peroxisome	nucleotide binding|RNA binding				0						AGCCTCAGGTGACCTTGCTGG	0.507000												
CDH5	1003	broad.mit.edu	37	16	66422264	66422264	+	Silent	SNP	C	C	T	rs112611173		TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr16:66422264C>T	uc002eom.3	+	4	693	c.537C>T	c.(535-537)GAC>GAT	p.D179D	CDH5_uc002eon.1_Silent_p.D179D	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	179	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TGGATGCAGACGACCCCACTG	0.527000												
MAP2K4	6416	broad.mit.edu	37	17	12043162	12043162	+	Silent	SNP	G	G	A	rs55794822	by1000genomes	TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr17:12043162G>A	uc002gnj.2	+	10	1116	c.1047G>A	c.(1045-1047)ACG>ACA	p.T349T	MAP2K4_uc002gnk.2_Silent_p.T360T|MAP2K4_uc010vvi.1_Silent_p.T231T|MAP2K4_uc010vvj.1_Silent_p.T221T	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	349	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(2)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		TTAGCCTTACGAAGGATGAAT	0.338000			D|Mis|N		pancreatic|breast|colorectal							
TMEM132E	124842	broad.mit.edu	37	17	32961845	32961845	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr17:32961845T>G	uc002hif.2	+	8	1774	c.1446T>G	c.(1444-1446)GAT>GAG	p.D482E		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	482	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		AGGATGAGGATGAGGAGGAGG	0.617000												
UBTF	7343	broad.mit.edu	37	17	42287592	42287592	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr17:42287592A>G	uc002igb.2	-	14	1593	c.1526T>C	c.(1525-1527)GTG>GCG	p.V509A	UBTF_uc002igc.2_Missense_Mutation_p.V472A|UBTF_uc010czs.2_Missense_Mutation_p.V509A|UBTF_uc002igd.2_Missense_Mutation_p.V472A|UBTF_uc010czt.2_Missense_Mutation_p.V509A|UBTF_uc002ige.2_Missense_Mutation_p.V472A	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	509	HMG box 5.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CAAGGCCTTCACCCGGTCATT	0.522000											OREG0024456	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
OR7A10	390892	broad.mit.edu	37	19	14952341	14952341	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:14952341C>T	uc002mzx.1	-	1	349	c.349G>A	c.(349-351)GTG>ATG	p.V117M		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					TAGGCCATCACGGTCAGAAGG	0.483000												
ZFP82	284406	broad.mit.edu	37	19	36884862	36884862	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:36884862A>G	uc002ody.1	-	5	615	c.380T>C	c.(379-381)ATT>ACT	p.I127T		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						CTGTCCTTCAATTTTTCCTGT	0.378000												
CATSPERG	57828	broad.mit.edu	37	19	38861176	38861176	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:38861176G>C	uc002oih.3	+	29	3311	c.3224G>C	c.(3223-3225)AGC>ACC	p.S1075T	CATSPERG_uc002oig.3_Missense_Mutation_p.S1035T|CATSPERG_uc002oif.3_Missense_Mutation_p.S715T|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1075	Helical; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						GTGTCAGCTAGCGTGTTTGTG	0.522000												
SPTBN4	57731	broad.mit.edu	37	19	41063215	41063215	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:41063215G>A	uc002ony.2	+	26	5662	c.5576G>A	c.(5575-5577)CGC>CAC	p.R1859H	SPTBN4_uc002onx.2_Missense_Mutation_p.R1859H|SPTBN4_uc002onz.2_Missense_Mutation_p.R1859H|SPTBN4_uc010egx.2_Missense_Mutation_p.R602H|SPTBN4_uc002ooa.2_Missense_Mutation_p.R535H	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1859	Spectrin 16.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGGCTGCCCCGCCTGACCACC	0.657000												
LIG1	3978	broad.mit.edu	37	19	48647219	48647219	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:48647219G>A	uc002pia.1	-	10	898	c.778C>T	c.(778-780)CCC>TCC	p.P260S	LIG1_uc010xze.1_5'UTR|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.P192S|LIG1_uc010xzg.1_Missense_Mutation_p.P229S|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	260					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GGATCCAGGGGTCTACGGAGG	0.433000								NER				
CEACAM18	729767	broad.mit.edu	37	19	51983739	51983739	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:51983739G>A	uc002pwv.1	+	3	388	c.388G>A	c.(388-390)GCA>ACA	p.A130T		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	130						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AAACGACAGCGCAGGAAACAT	0.562000												
IL11	3589	broad.mit.edu	37	19	55877404	55877404	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:55877404C>T	uc002qks.1	-	5	707	c.571G>A	c.(571-573)GGA>AGA	p.G191R	FAM71E2_uc002qkr.2_5'Flank|FAM71E2_uc002qkq.2_5'Flank|IL11_uc010yfx.1_Missense_Mutation_p.G112R	NM_000641	NP_000632	P20809	IL11_HUMAN	interleukin 11 precursor	191					B cell differentiation|fat cell differentiation|megakaryocyte differentiation|negative regulation of hormone secretion|platelet activation|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity|growth factor activity|interleukin-11 receptor binding				0	Breast(117;0.191)	Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Oprelvekin(DB00038)	AGCAGCAGTCCCCTCACGGCC	0.542000												
TMEM190	147744	broad.mit.edu	37	19	55889178	55889178	+	Missense_Mutation	SNP	C	C	T	rs146395464		TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:55889178C>T	uc002qkt.1	+	4	247	c.229C>T	c.(229-231)CGG>TGG	p.R77W		NM_139172	NP_631911	Q8WZ59	TM190_HUMAN	transmembrane protein 190 precursor	77	Extracellular (Potential).					integral to membrane					0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AGAAAACGTGCGGAGGAAGCA	0.677000												
ZSCAN18	65982	broad.mit.edu	37	19	58601554	58601554	+	Silent	SNP	G	G	A	rs149865437	byFrequency	TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:58601554G>A	uc002qri.2	-	2	390	c.81C>T	c.(79-81)GCC>GCT	p.A27A	ZSCAN18_uc002qrj.3_Silent_p.A27A|ZSCAN18_uc010yhs.1_Intron|ZSCAN18_uc002qrh.2_Silent_p.A27A|ZSCAN18_uc010yht.1_Silent_p.A83A|ZSCAN18_uc002qrk.1_Silent_p.A27A|ZSCAN18_uc002qrl.2_Silent_p.A27A	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	27					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCTGGACTCCGGCTGCTGACC	0.632000												
LTBP1	4052	broad.mit.edu	37	2	33589405	33589405	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr2:33589405C>T	uc002ros.2	+	30	4525	c.4525C>T	c.(4525-4527)CGA>TGA	p.R1509*	LTBP1_uc002rot.2_Nonsense_Mutation_p.R1183*|LTBP1_uc002rou.2_Nonsense_Mutation_p.R1182*|LTBP1_uc002rov.2_Nonsense_Mutation_p.R1129*|LTBP1_uc010ymz.1_Nonsense_Mutation_p.R1140*|LTBP1_uc010yna.1_Nonsense_Mutation_p.R1087*|LTBP1_uc010ynb.1_Nonsense_Mutation_p.R406*	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1508					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGATGTATACGACCGGCTGA	0.408000												
ZNF638	27332	broad.mit.edu	37	2	71591185	71591185	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr2:71591185G>A	uc002shx.2	+	5	1839	c.1520G>A	c.(1519-1521)CGG>CAG	p.R507Q	ZNF638_uc010fec.2_Missense_Mutation_p.R613Q|ZNF638_uc010yqw.1_Missense_Mutation_p.R86Q|ZNF638_uc002shw.2_Missense_Mutation_p.R507Q|ZNF638_uc002shy.2_Missense_Mutation_p.R507Q|ZNF638_uc002shz.2_Missense_Mutation_p.R507Q|ZNF638_uc002sia.2_Missense_Mutation_p.R507Q|ZNF638_uc002sib.1_Missense_Mutation_p.R507Q|ZNF638_uc010fed.2_5'Flank	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	507	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AGATTCCGTCGGTCTCGAAGC	0.453000												
IWS1	55677	broad.mit.edu	37	2	128244161	128244161	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr2:128244161G>A	uc002ton.2	-	13	2599	c.2296C>T	c.(2296-2298)CCC>TCC	p.P766S		NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	766					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TTCCATTTGGGCCTGACAACA	0.493000												
SGOL2	151246	broad.mit.edu	37	2	201437550	201437550	+	Missense_Mutation	SNP	G	G	C	rs150234762	by1000genomes	TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr2:201437550G>C	uc002uvw.2	+	7	2594	c.2481G>C	c.(2479-2481)GAG>GAC	p.E827D	SGOL2_uc010zhd.1_Missense_Mutation_p.E827D|SGOL2_uc010zhe.1_Missense_Mutation_p.E827D	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	827					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AAATATATGAGAATGATAACA	0.323000												
PTPRN	5798	broad.mit.edu	37	2	220164444	220164444	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr2:220164444A>G	uc002vkz.2	-	10	1590	c.1501T>C	c.(1501-1503)TCA>CCA	p.S501P	PTPRN_uc010zlc.1_Missense_Mutation_p.S411P|PTPRN_uc002vla.2_Intron	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	501	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		AAGCTGCCTGAGGACATGTGC	0.602000												
TOX2	84969	broad.mit.edu	37	20	42695404	42695404	+	Missense_Mutation	SNP	C	C	T	rs149010935		TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr20:42695404C>T	uc002xlf.3	+	7	1354	c.1337C>T	c.(1336-1338)TCG>TTG	p.S446L	TOX2_uc010ggo.2_Missense_Mutation_p.S464L|TOX2_uc002xle.3_Missense_Mutation_p.S422L|TOX2_uc010ggp.2_Missense_Mutation_p.S422L|TOX2_uc002xlg.2_Missense_Mutation_p.S263L|TOX2_uc010zwk.1_Missense_Mutation_p.S342L	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	446	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCCAGCAGCTCGGGATCCTGC	0.632000												
DIDO1	11083	broad.mit.edu	37	20	61512983	61512983	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr20:61512983T>A	uc002ydr.1	-	16	4589	c.4325A>T	c.(4324-4326)GAT>GTT	p.D1442V	DIDO1_uc002yds.1_Missense_Mutation_p.D1442V	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1442					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGGCAGGTCATCAACAGTCAC	0.622000												
CHL1	10752	broad.mit.edu	37	3	439943	439943	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr3:439943T>A	uc003bou.2	+	24	3351	c.3080T>A	c.(3079-3081)CTT>CAT	p.L1027H	CHL1_uc003bot.2_Missense_Mutation_p.L1043H|CHL1_uc003bow.1_Missense_Mutation_p.L1027H|CHL1_uc011asi.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1027	Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GGAGTAAATCTTACTCAAAAG	0.348000												
CACNA1D	776	broad.mit.edu	37	3	53757546	53757546	+	Silent	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr3:53757546C>T	uc003dgv.3	+	13	1915	c.1752C>T	c.(1750-1752)GTC>GTT	p.V584V	CACNA1D_uc003dgu.3_Silent_p.V604V|CACNA1D_uc003dgy.3_Silent_p.V584V|CACNA1D_uc003dgw.3_Silent_p.V251V	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	584	Cytoplasmic (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CATATTTCGTCTCTCTTTTCA	0.478000												
IGSF10	285313	broad.mit.edu	37	3	151155062	151155062	+	Silent	SNP	G	G	C			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr3:151155062G>C	uc011bod.1	-	6	7287	c.7287C>G	c.(7285-7287)GGC>GGG	p.G2429G	IGSF10_uc011bob.1_Silent_p.G456G|IGSF10_uc011boc.1_Silent_p.G408G	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2429					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGGCTTCTGGCCAATTTCTA	0.403000												
EIF4G1	1981	broad.mit.edu	37	3	184046450	184046450	+	Missense_Mutation	SNP	A	A	G	rs112809828		TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr3:184046450A>G	uc003fnp.2	+	27	4183	c.3985A>G	c.(3985-3987)ATG>GTG	p.M1329V	EIF4G1_uc003fnt.2_Missense_Mutation_p.M1040V|EIF4G1_uc003fnq.2_Missense_Mutation_p.M1242V|EIF4G1_uc003fnr.2_Missense_Mutation_p.M1165V|EIF4G1_uc010hxx.2_Missense_Mutation_p.M1336V|EIF4G1_uc003fns.2_Missense_Mutation_p.M1289V|EIF4G1_uc010hxy.2_Missense_Mutation_p.M1336V|EIF4G1_uc003fnv.3_Missense_Mutation_p.M1330V|EIF4G1_uc003fnu.3_Missense_Mutation_p.M1329V|EIF4G1_uc003fnw.2_Missense_Mutation_p.M1336V|EIF4G1_uc003fnx.2_Missense_Mutation_p.M1134V|EIF4G1_uc003fny.3_Missense_Mutation_p.M1133V|EIF4G1_uc003foa.2_Missense_Mutation_p.M1V	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1329	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCTGAGGACATGGAAATTGA	0.532000												
PPP2R2C	5522	broad.mit.edu	37	4	6325201	6325201	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr4:6325201C>T	uc003gjc.2	-	9	1542	c.1172G>A	c.(1171-1173)CGG>CAG	p.R391Q	PPP2R2C_uc003gjb.2_Missense_Mutation_p.R374Q|PPP2R2C_uc011bwd.1_Missense_Mutation_p.R384Q|PPP2R2C_uc011bwe.1_Missense_Mutation_p.R384Q|PPP2R2C_uc003gja.2_Missense_Mutation_p.R391Q	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	391					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						GCACACGCGCCGTGGCTTGAG	0.627000												
TLL1	7092	broad.mit.edu	37	4	166981211	166981211	+	Silent	SNP	C	C	T	rs114032464	by1000genomes	TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr4:166981211C>T	uc003irh.1	+	15	2525	c.1878C>T	c.(1876-1878)AAC>AAT	p.N626N	TLL1_uc011cjn.1_Silent_p.N649N|TLL1_uc011cjo.1_Silent_p.N450N	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	626	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CCAAACTTAACGGCACCATAA	0.463000												
MYO10	4651	broad.mit.edu	37	5	16671582	16671582	+	Silent	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr5:16671582G>A	uc003jft.3	-	38	5847	c.5379C>T	c.(5377-5379)GAC>GAT	p.D1793D	MYO10_uc011cnb.1_Silent_p.D422D|MYO10_uc011cnc.1_Silent_p.D672D|MYO10_uc011cnd.1_Silent_p.D1150D|MYO10_uc011cne.1_Silent_p.D1150D|MYO10_uc010itx.2_Silent_p.D1415D	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1793	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CGTTGTCTGTGTCCAGGAAGC	0.463000												
MAST4	375449	broad.mit.edu	37	5	66430464	66430464	+	Silent	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr5:66430464C>T	uc003jut.1	+	17	1841	c.1773C>T	c.(1771-1773)TGC>TGT	p.C591C	MAST4_uc003juu.1_Silent_p.C601C|MAST4_uc011cra.1_Silent_p.C574C|MAST4_uc003juv.2_Silent_p.C586C|MAST4_uc003juw.2_Silent_p.C586C	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	783	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TGGTTGGATGCGTGCCATTCT	0.468000												
FTSJD2	23070	broad.mit.edu	37	6	37440259	37440259	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr6:37440259T>C	uc003ons.2	+	16	1938	c.1685T>C	c.(1684-1686)ATC>ACC	p.I562T		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	562					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TTTGAGCTAATCCAGGTAAGA	0.468000												
GPR115	221393	broad.mit.edu	37	6	47675062	47675062	+	Silent	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr6:47675062G>A	uc003oza.1	+	2	339	c.81G>A	c.(79-81)AAG>AAA	p.K27K	GPR115_uc003oyz.1_Silent_p.K84K|GPR115_uc003ozb.1_Silent_p.K25K	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	27	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						ATAGATCCAAGATTCACCTAA	0.398000												
COL10A1	1300	broad.mit.edu	37	6	116442355	116442355	+	Silent	SNP	T	T	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr6:116442355T>G	uc003pwm.2	-	3	1020	c.924A>C	c.(922-924)GGA>GGC	p.G308G	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	308	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		GTCCTCTTTCTCCCTTCAGGC	0.632000												
SYNE1	23345	broad.mit.edu	37	6	152711422	152711422	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr6:152711422C>T	uc010kiw.2	-	53	8772	c.8170G>A	c.(8170-8172)GCT>ACT	p.A2724T	SYNE1_uc003qot.3_Missense_Mutation_p.A2731T|SYNE1_uc003qou.3_Missense_Mutation_p.A2724T|SYNE1_uc010kjb.1_Missense_Mutation_p.A2707T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2724	Cytoplasmic (Potential).|HAT 5.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TACCTTTGAGCGTGGACGGAG	0.463000										HNSCC(10;0.0054)		
ACHE	43	broad.mit.edu	37	7	100489999	100489999	+	Silent	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr7:100489999G>A	uc003uxd.2	-	2	1665	c.1509C>T	c.(1507-1509)TTC>TTT	p.F503F	UFSP1_uc003uxc.3_5'Flank|ACHE_uc003uxe.2_Silent_p.F503F|ACHE_uc003uxf.2_Silent_p.F503F|ACHE_uc003uxg.2_Silent_p.F503F|ACHE_uc003uxh.2_Silent_p.F415F|ACHE_uc003uxi.2_Silent_p.F503F	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	503					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GTCGCTGGGCGAAGATTTTCT	0.627000												
CASP2	835	broad.mit.edu	37	7	143001838	143001838	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr7:143001838C>T	uc003wco.2	+	10	1336	c.1189C>T	c.(1189-1191)CGG>TGG	p.R397W	CASP2_uc003wcp.2_3'UTR|CASP2_uc011kta.1_Missense_Mutation_p.R281W|CASP2_uc003wcq.2_RNA|CASP2_uc011ktb.1_Missense_Mutation_p.R147W	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	397					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					GTTTTCTGAGCGGGCTTGTGA	0.552000												
SNTG1	54212	broad.mit.edu	37	8	51617181	51617181	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr8:51617181C>T	uc010lxy.1	+	17	1431	c.1060C>T	c.(1060-1062)CGG>TGG	p.R354W	SNTG1_uc003xqs.1_Missense_Mutation_p.R354W|SNTG1_uc010lxz.1_Missense_Mutation_p.R354W|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	354	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GCTGGACCGACGGAAACAGTG	0.557000												
CHD7	55636	broad.mit.edu	37	8	61693580	61693580	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr8:61693580C>G	uc003xue.2	+	3	2164	c.1687C>G	c.(1687-1689)CTA>GTA	p.L563V		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	563	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGAGCCCTTTCTAGAGAAACC	0.433000												
FAM92A1	137392	broad.mit.edu	37	8	94717228	94717228	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr8:94717228G>A	uc010maq.2	+	4	525	c.422G>A	c.(421-423)CGA>CAA	p.R141Q	FAM92A1_uc003yfu.1_RNA|FAM92A1_uc003yfv.3_RNA	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	141	Potential.										0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CCATCTGATCGACATGTTATT	0.338000												
CSMD3	114788	broad.mit.edu	37	8	113318352	113318352	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr8:113318352G>A	uc003ynu.2	-	51	8114	c.7955C>T	c.(7954-7956)ACG>ATG	p.T2652M	CSMD3_uc003yns.2_Missense_Mutation_p.T1854M|CSMD3_uc003ynt.2_Missense_Mutation_p.T2612M|CSMD3_uc011lhx.1_Missense_Mutation_p.T2548M	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2652	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTAACTCGCGTTCCTACCAA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
DMRT2	10655	broad.mit.edu	37	9	1056234	1056234	+	Missense_Mutation	SNP	C	C	T	rs150037258	byFrequency	TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr9:1056234C>T	uc003zha.2	+	4	847	c.647C>T	c.(646-648)GCG>GTG	p.A216V	DMRT2_uc003zgx.3_5'UTR|DMRT2_uc010mgz.2_5'UTR|DMRT2_uc003zgy.3_Missense_Mutation_p.A60V|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.A216V	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	216					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		CCCATTCCAGCGGAGACTTAT	0.448000												
KIAA2026	158358	broad.mit.edu	37	9	5968714	5968714	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr9:5968714C>T	uc003zjq.3	-	3	1733	c.1517G>A	c.(1516-1518)CGG>CAG	p.R506Q		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	506										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CAATTTAATCCGAGGTACTCT	0.408000												
DIRAS2	54769	broad.mit.edu	37	9	93375892	93375892	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr9:93375892C>T	uc004aqx.1	-	2	329	c.218G>A	c.(217-219)CGG>CAG	p.R73Q		NM_017594	NP_060064	Q96HU8	DIRA2_HUMAN	Di-Ras2	73					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity				0						GATGGACAGCCGCTGCATGGC	0.567000												
GLT6D1	360203	broad.mit.edu	37	9	138516139	138516139	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr9:138516139G>T	uc010nbd.1	-	5	889	c.635C>A	c.(634-636)CCG>CAG	p.P212Q		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	212	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		TGCTGAGGTCGGCCTCCTCTC	0.512000												
KDM6A	7403	broad.mit.edu	37	X	44942724	44942724	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chrX:44942724G>A	uc004dge.3	+	23	3679	c.3304G>A	c.(3304-3306)GAG>AAG	p.E1102K	KDM6A_uc011mkz.1_Missense_Mutation_p.E1154K|KDM6A_uc011mla.1_Missense_Mutation_p.E1057K|KDM6A_uc011mlb.1_Missense_Mutation_p.E1109K|KDM6A_uc011mlc.1_Missense_Mutation_p.E806K|KDM6A_uc011mld.1_Missense_Mutation_p.E741K	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1102	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GCAGCTACATGAGCTGACTAA	0.398000			D|N|F|S		renal|oesophageal SCC|MM							
DNASE1L1	1774	broad.mit.edu	37	X	153631879	153631879	+	Silent	SNP	G	G	A			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chrX:153631879G>A	uc004fks.1	-	5	587	c.396C>T	c.(394-396)TTC>TTT	p.F132F	RPL10_uc004fkq.1_RNA|RPL10_uc004fkr.1_3'UTR|DNASE1L1_uc004fkt.1_Silent_p.F132F|DNASE1L1_uc004fku.1_Silent_p.F132F|DNASE1L1_uc004fkv.1_Silent_p.F132F|DNASE1L1_uc004fkw.1_Silent_p.F132F	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor	132					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGGGCAAAGAGAACTGGGCCA	0.577000												
SULF1	23213	broad.mit.edu	37	8	70515861	70515862	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr8:70515860_70515861A>AT	uc003xyg.2	+	10	1777_1778	c.1216_1217A>AT	c.(1216-1218)attfs	p.I406fs	SULF1_uc010lza.1_Frame_Shift_Ins_p.I406fs|SULF1_uc003xyd.2_Frame_Shift_Ins_p.I406fs|SULF1_uc003xye.2_Frame_Shift_Ins_p.I406fs|SULF1_uc003xyf.2_Frame_Shift_Ins_p.I406fs|SULF1_uc003xyh.1_Non-coding_Transcript	NM_001128206	NP_055985	Q8IWU6	SULF1_HUMAN	Homo sapiens sulfatase 1 (SULF1), transcript variant 2, mRNA.	406					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	Golgi stack|cell surface|endoplasmic reticulum|extracellular space	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GAAGGCCAAAATTTGGCGTGAT	0.411												
AOC3	8639	broad.mit.edu	37	17	41003597	41003598	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr17:41003596_41003597T>TG	uc002ibv.3	+	0	396_397	c.236_237T>TG	c.(235-237)ctgfs	p.L79fs		NM_003734	NP_003725	Q16853	AOC3_HUMAN	Homo sapiens amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3), mRNA.	79					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	ACCCAGCGGCTGGGGCCAGGGC	0.658												
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653												
ZSCAN18	65982	broad.mit.edu	37	19	58600101	58600102	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-CD-8534-01A-11D-2340-08	TCGA-CD-8534-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0530d3ac-b94b-406c-8edf-9e0539358a3d	cb35c60a-d9cc-4eaa-ad47-fef2ef766697	g.chr19:58600100_58600101T>TGG	uc010yht.1	-	2	705_706	c.675_676A>CCA	c.(673-678)cccagcfs	p.P225fs	ZSCAN18_uc002qrj.3_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc010yhs.1_Frame_Shift_Ins_p.P34fs|ZSCAN18_uc002qrh.2_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc002qri.2_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc002qrk.1_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc002qrl.2_Frame_Shift_Ins_p.P169fs	NM_001145542	NP_001139014	Q8TBC5	ZSC18_HUMAN	Homo sapiens zinc finger and SCAN domain containing 18 (ZSCAN18), transcript variant 1, mRNA.	169					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGGGCCTGGCTGGGGCTCGCGA	0.649												
