Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
KLHL21	9903	broad.mit.edu	37	1	6653646	6653646	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:6653646C>A	uc001aoa.2	-	4	1625	c.1573G>T	c.(1573-1575)GAA>TAA	p.E525*	KLHL21_uc001anz.1_3'UTR|KLHL21_uc009vme.2_Nonsense_Mutation_p.E158*	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	525	Kelch 6.				anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		TCCGAGAGTTCAAATGTATTG	0.607												
AKR7A3	22977	broad.mit.edu	37	1	19612421	19612421	+	Silent	SNP	G	G	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:19612421G>C	uc001bbv.1	-	3	545	c.468C>G	c.(466-468)CTC>CTG	p.L156L		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	156					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTCTTGCAGAGGGTACAGA	0.587												
DLGAP3	58512	broad.mit.edu	37	1	35370318	35370318	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:35370318G>T	uc001byc.2	-	1	667	c.667C>A	c.(667-669)CAT>AAT	p.H223N		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	223	Poly-His.				cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				tggtggtgatggGAGGTGTGG	0.552												
ORC1L	4998	broad.mit.edu	37	1	52861837	52861837	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:52861837G>A	uc001ctt.2	-	5	821	c.602C>T	c.(601-603)TCT>TTT	p.S201F	ORC1L_uc010oni.1_Missense_Mutation_p.S201F|ORC1L_uc001ctu.2_Missense_Mutation_p.S201F|ORC1L_uc009vzd.2_5'UTR	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	201					cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						TGGGGTCCAAGAAGGGCTCTC	0.512												
ROR1	4919	broad.mit.edu	37	1	64643444	64643444	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:64643444G>A	uc001dbj.2	+	9	2119	c.1720G>A	c.(1720-1722)GGC>AGC	p.G574S	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	574	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						CTCTGATGTTGGCTGCAGCAG	0.483												
LRRC8B	23507	broad.mit.edu	37	1	90050004	90050004	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:90050004C>T	uc001dni.2	+	7	2302	c.1795C>T	c.(1795-1797)CGC>TGC	p.R599C	LRRC8B_uc001dnh.2_Missense_Mutation_p.R599C|LRRC8B_uc001dnj.2_Missense_Mutation_p.R599C	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	599	LRR 6.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TGACCTGGAACGCATCCCACA	0.403												
FLG	2312	broad.mit.edu	37	1	152283559	152283559	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:152283559G>T	uc001ezu.1	-	3	3839	c.3803C>A	c.(3802-3804)TCC>TAC	p.S1268Y	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1268	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTAACACTGGATCCCTGGTG	0.468									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152286203	152286203	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:152286203C>T	uc001ezu.1	-	3	1195	c.1159G>A	c.(1159-1161)GGC>AGC	p.G387S	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	387	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTGGTGGCCGGATCCATGT	0.582									Ichthyosis			
IQGAP3	128239	broad.mit.edu	37	1	156496382	156496382	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:156496382G>T	uc001fpf.2	-	38	4867	c.4792C>A	c.(4792-4794)CAG>AAG	p.Q1598K		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1598					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TACTGGAGCTGCAGGAGATCC	0.493												
ADCY10	55811	broad.mit.edu	37	1	167874377	167874377	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:167874377A>G	uc001ger.2	-	2	300	c.2T>C	c.(1-3)ATG>ACG	p.M1T	ADCY10_uc009wvk.2_5'UTR|ADCY10_uc010plj.1_Intron|ADCY10_uc009wvl.2_Missense_Mutation_p.M1T|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TGGAGTGTTCATGTTCAAGAC	0.398												
HMCN1	83872	broad.mit.edu	37	1	186114580	186114580	+	Missense_Mutation	SNP	G	G	A	rs141397809		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:186114580G>A	uc001grq.1	+	92	14541	c.14312G>A	c.(14311-14313)CGG>CAG	p.R4771Q	HMCN1_uc001grs.1_Missense_Mutation_p.R340Q	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4771	TSP type-1 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACATGCAGCCGGACGTGTAAC	0.552												
CFHR3	10878	broad.mit.edu	37	1	196749062	196749062	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:196749062C>T	uc001gtl.2	+	3	476	c.389C>T	c.(388-390)ACG>ATG	p.T130M	CFHR3_uc001gtk.2_Missense_Mutation_p.T130M|CFHR3_uc010poy.1_Missense_Mutation_p.T130M|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	130	Sushi 2.					extracellular space					0						GTTACATGTACGGAGAAAGGC	0.473												
PM20D1	148811	broad.mit.edu	37	1	205817084	205817084	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:205817084G>A	uc001hdj.2	-	2	230	c.185C>T	c.(184-186)CCA>CTA	p.P62L	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	62						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			AGTCACTGTTGGAATCTGGAT	0.403												
FMN2	56776	broad.mit.edu	37	1	240371492	240371492	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:240371492C>T	uc010pyd.1	+	5	3605	c.3380C>T	c.(3379-3381)GCG>GTG	p.A1127V	FMN2_uc010pye.1_Missense_Mutation_p.A1131V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1127	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTACCCGGAGCGGGCATACCC	0.721												
DOCK1	1793	broad.mit.edu	37	10	129179558	129179558	+	Missense_Mutation	SNP	T	T	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr10:129179558T>C	uc001ljt.2	+	37	3734	c.3670T>C	c.(3670-3672)TGT>CGT	p.C1224R	DOCK1_uc010qun.1_Missense_Mutation_p.C1245R|DOCK1_uc009yaq.2_Missense_Mutation_p.C219R	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1224	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GTACAAGCTCTGTGACCTGCA	0.388												
MUC5B	727897	broad.mit.edu	37	11	1263339	1263339	+	Silent	SNP	G	G	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:1263339G>C	uc009ycr.1	+	47	7434	c.7308G>C	c.(7306-7308)ACG>ACC	p.T2436T	MUC5B_uc001ltb.2_Silent_p.T1746T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1743	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGCTGACCACGAGCCTGGCGC	0.642												
APBB1	322	broad.mit.edu	37	11	6432394	6432394	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:6432394G>T	uc001mdb.1	-	2	284	c.184C>A	c.(184-186)CCA>ACA	p.P62T	APBB1_uc001mdc.1_Missense_Mutation_p.P62T|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	62					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GCAGGGCCTGGCTCAGGCCCA	0.662												
PTPRJ	5795	broad.mit.edu	37	11	48149352	48149352	+	Missense_Mutation	SNP	G	G	A	rs2229703	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:48149352G>A	uc001ngp.3	+	7	1469	c.1114G>A	c.(1114-1116)GTC>ATC	p.V372I	PTPRJ_uc001ngo.3_Missense_Mutation_p.V372I	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	372	Extracellular (Potential).|Fibronectin type-III 4.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity	p.V372L(1)		breast(3)|kidney(3)|ovary(1)|skin(1)	8						GGTTTTTGACGTCACCGCTGT	0.498												
OR9G4	283189	broad.mit.edu	37	11	56510343	56510343	+	Silent	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:56510343G>T	uc010rjo.1	-	1	945	c.945C>A	c.(943-945)GCC>GCA	p.A315A		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	315	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CTTTCCTGAAGGCCTCTTTGA	0.408												
BAD	572	broad.mit.edu	37	11	64037700	64037700	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:64037700C>T	uc001nzd.2	-	4	570	c.488G>A	c.(487-489)AGC>AAC	p.S163N	BAD_uc001nzc.2_Missense_Mutation_p.S163N|GPR137_uc009ypj.1_5'UTR	NM_032989	NP_116784	Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	163					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)	1						GGGGGCGGAGCTTCCCCTGCC	0.637												
SLC22A12	116085	broad.mit.edu	37	11	64360337	64360337	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:64360337C>T	uc001oam.1	+	2	1236	c.489C>T	c.(487-489)TGC>TGT	p.C163C	SLC22A12_uc009ypr.1_Silent_p.C163C|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Silent_p.C163C|SLC22A12_uc001oan.1_Silent_p.C163C|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	163	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CTGCTGCGTGCGGCCCTGCCT	0.627												
CADM1	23705	broad.mit.edu	37	11	115099839	115099839	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:115099839C>A	uc001ppi.3	-	5	844	c.715G>T	c.(715-717)GTA>TTA	p.V239L	CADM1_uc001ppf.3_Missense_Mutation_p.V239L|CADM1_uc001ppk.3_Missense_Mutation_p.V239L|CADM1_uc001ppj.3_Missense_Mutation_p.V239L|CADM1_uc001ppl.2_Missense_Mutation_p.V239L	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	239	Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TCACACTGTACTTCTAGATAC	0.483												
APOA5	116519	broad.mit.edu	37	11	116661339	116661339	+	Silent	SNP	G	G	A	rs140482460		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:116661339G>A	uc001ppr.2	-	3	614	c.606C>T	c.(604-606)ATC>ATT	p.I202I	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Silent_p.I202I|APOA5_uc009yzf.2_Silent_p.I202I|APOA5_uc009yzg.2_Silent_p.I228I	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	202					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		CGTGGCGCCCGATGCCGCTCA	0.697												
GRIK4	2900	broad.mit.edu	37	11	120531035	120531035	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:120531035G>A	uc001pxn.2	+	3	295	c.8G>A	c.(7-9)CGC>CAC	p.R3H	GRIK4_uc009zav.1_Missense_Mutation_p.R3H|GRIK4_uc009zaw.1_Missense_Mutation_p.R3H|GRIK4_uc009zax.1_Missense_Mutation_p.R3H	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	3					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	AAGATGCCCCGCGTCTCGGCG	0.637											OREG0021424	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
GRIK4	2900	broad.mit.edu	37	11	120732714	120732714	+	Missense_Mutation	SNP	A	A	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:120732714A>T	uc001pxn.2	+	9	1078	c.791A>T	c.(790-792)AAC>ATC	p.N264I	GRIK4_uc009zav.1_Missense_Mutation_p.N264I|GRIK4_uc009zaw.1_Missense_Mutation_p.N264I|GRIK4_uc009zax.1_Missense_Mutation_p.N264I	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	264	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GATCGTGTCAACATCCTGGGA	0.488												
ADAMTS8	11095	broad.mit.edu	37	11	130297579	130297579	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:130297579C>T	uc001qgg.3	-	1	961	c.603G>A	c.(601-603)CCG>CCA	p.P201P		NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	201	Poly-Pro.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GGGGCGGTGGCGGCTCGCTAG	0.657												
PDZRN4	29951	broad.mit.edu	37	12	41900470	41900470	+	Silent	SNP	T	T	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:41900470T>A	uc010skn.1	+	4	527	c.459T>A	c.(457-459)CCT>CCA	p.P153P	PDZRN4_uc001rmq.3_Silent_p.P94P|PDZRN4_uc009zjz.2_Silent_p.P92P|PDZRN4_uc001rmr.2_5'Flank	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	352							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTCGTCCACCTACCCCTCCAG	0.493												
MAP3K12	7786	broad.mit.edu	37	12	53879109	53879109	+	Silent	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:53879109G>T	uc001sdm.1	-	6	971	c.873C>A	c.(871-873)GTC>GTA	p.V291V	MAP3K12_uc001sdn.1_Silent_p.V324V	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	291	Protein kinase.				histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						ACCAGATGTCGACCTTCTCAG	0.557												
MARS	4141	broad.mit.edu	37	12	57898029	57898029	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:57898029C>T	uc001sog.2	+	11	1338	c.1315C>T	c.(1315-1317)CGA>TGA	p.R439*	MARS_uc001sof.1_RNA|MARS_uc010srp.1_Nonsense_Mutation_p.R312*|MARS_uc010srq.1_Nonsense_Mutation_p.R205*	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	439					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TAAAGTCTGCCGATCATGCCC	0.557												
OS9	10956	broad.mit.edu	37	12	58109707	58109707	+	Silent	SNP	T	T	G	rs73125477	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:58109707T>G	uc001spj.2	+	6	803	c.744T>G	c.(742-744)CCT>CCG	p.P248P	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Silent_p.P248P|OS9_uc001spl.2_Silent_p.P248P|OS9_uc001spm.2_Silent_p.P248P|OS9_uc001spn.2_Silent_p.P248P|OS9_uc010sry.1_Silent_p.P215P|OS9_uc010srz.1_Silent_p.P189P	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	248					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TCTGTCACCCTTCCCTACAGC	0.627												
C12orf66	144577	broad.mit.edu	37	12	64587770	64587770	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:64587770C>T	uc001srw.3	-	3	1249	c.1190G>A	c.(1189-1191)CGC>CAC	p.R397H	C12orf66_uc009zql.2_Missense_Mutation_p.R344H	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	397										ovary(1)	1						AGGTTCCGGGCGGGTTAGGAA	0.448												
MGAT4C	25834	broad.mit.edu	37	12	86373542	86373542	+	Missense_Mutation	SNP	G	G	A	rs145801611	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:86373542G>A	uc001tai.3	-	8	2212	c.962C>T	c.(961-963)ACG>ATG	p.T321M	MGAT4C_uc001tal.3_Missense_Mutation_p.T321M|MGAT4C_uc001taj.3_Missense_Mutation_p.T321M|MGAT4C_uc001tak.3_Missense_Mutation_p.T321M|MGAT4C_uc010sum.1_Missense_Mutation_p.T345M|MGAT4C_uc001tah.3_Missense_Mutation_p.T321M	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	321	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						CTTATTCTCCGTCCCTTTGTA	0.403												
WSCD2	9671	broad.mit.edu	37	12	108641943	108641943	+	Silent	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:108641943G>T	uc001tms.2	+	9	2265	c.1521G>T	c.(1519-1521)CTG>CTT	p.L507L	WSCD2_uc001tmt.2_Silent_p.L507L|WSCD2_uc001tmu.2_Silent_p.L275L	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	507						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						AGGACCGGCTGCTCTGTGTGG	0.602												
RAP2A	5911	broad.mit.edu	37	13	98116563	98116563	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr13:98116563G>T	uc001vnd.2	+	2	669	c.419G>T	c.(418-420)TGC>TTC	p.C140F		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	140					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			GAGTGGGGCTGCCCCTTTATG	0.488												
MYO16	23026	broad.mit.edu	37	13	109792648	109792648	+	Missense_Mutation	SNP	G	G	T	rs145367903		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr13:109792648G>T	uc001vqt.1	+	32	4148	c.4022G>T	c.(4021-4023)AGC>ATC	p.S1341I	MYO16_uc010agk.1_Missense_Mutation_p.S1363I	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1341					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GACGACTACAGCACCATGAAG	0.602												
PRKD1	5587	broad.mit.edu	37	14	30102110	30102110	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:30102110G>A	uc001wqh.2	-	9	1538	c.1357C>T	c.(1357-1359)CTC>TTC	p.L453F		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	453	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTCTGAAAGAGGGTAATACAT	0.368												
BAZ1A	11177	broad.mit.edu	37	14	35224069	35224069	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:35224069G>A	uc001wsk.2	-	26	5006	c.4438C>T	c.(4438-4440)CGT>TGT	p.R1480C	BAZ1A_uc001wsl.2_Missense_Mutation_p.R1448C	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1480	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		ACTTTTTCACGAATTATATTT	0.284												
LRFN5	145581	broad.mit.edu	37	14	42356169	42356169	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:42356169T>G	uc001wvm.2	+	3	1539	c.341T>G	c.(340-342)ATT>AGT	p.I114S	LRFN5_uc010ana.2_Missense_Mutation_p.I114S	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	114	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTGACTAAAATTACAAATGAT	0.353										HNSCC(30;0.082)		
GNPNAT1	64841	broad.mit.edu	37	14	53251263	53251263	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:53251263C>T	uc001xab.2	-	2	361	c.106G>A	c.(106-108)GGA>AGA	p.G36R		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	36					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					AAGCCTTCTCCAGGATGTGTT	0.408												
TMEM90A	646658	broad.mit.edu	37	14	74876050	74876050	+	Missense_Mutation	SNP	T	T	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:74876050T>C	uc001xpx.2	-	2	646	c.398A>G	c.(397-399)GAT>GGT	p.D133G		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	133					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		CTCCTGGTCATCCTCCTGGTC	0.418												
KCNK13	56659	broad.mit.edu	37	14	90651110	90651110	+	Silent	SNP	C	C	T	rs139112374		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:90651110C>T	uc001xye.1	+	2	1432	c.990C>T	c.(988-990)GAC>GAT	p.D330D		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	330	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TAGAGACAGACGGGGTGGCAG	0.622												
SLTM	79811	broad.mit.edu	37	15	59186099	59186099	+	Silent	SNP	A	A	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:59186099A>G	uc002afp.2	-	12	1657	c.1569T>C	c.(1567-1569)GGT>GGC	p.G523G	SLTM_uc002afn.2_Splice_Site_p.G92_splice|SLTM_uc002afo.2_Silent_p.G505G|SLTM_uc002afq.2_Silent_p.G92G|SLTM_uc010bgd.2_Silent_p.G92G	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	523					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TCTCATCTTTACCTTCTATTT	0.348												
DENND4A	10260	broad.mit.edu	37	15	65988761	65988761	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:65988761C>T	uc002aph.2	-	21	3271	c.2893G>A	c.(2893-2895)GTT>ATT	p.V965I	DENND4A_uc002api.2_Missense_Mutation_p.V1008I|DENND4A_uc002apj.3_Missense_Mutation_p.V965I	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	965					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GTGAGGCGAACGATACTGGAA	0.383												
CORO2B	10391	broad.mit.edu	37	15	69004026	69004026	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:69004026G>A	uc002arj.3	+	5	658	c.629G>A	c.(628-630)CGC>CAC	p.R210H	CORO2B_uc010bic.2_Missense_Mutation_p.R205H|CORO2B_uc002ark.2_5'Flank	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	210	WD 3.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						ATTGAGCCCCGCTCTGGCCGT	0.557												
C15orf42	90381	broad.mit.edu	37	15	90164697	90164697	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:90164697G>T	uc002boe.2	+	19	3228	c.3228G>T	c.(3226-3228)ATG>ATT	p.M1076I	C15orf42_uc010upv.1_5'Flank	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1076					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGTCTGAGATGATCAGCCCCT	0.423												
PKD1	5310	broad.mit.edu	37	16	2143019	2143019	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:2143019C>A	uc002cos.1	-	38	11301	c.11092G>T	c.(11092-11094)GCC>TCC	p.A3698S	PKD1_uc002cot.1_Missense_Mutation_p.A3697S|MIR1225_hsa-mir-1225|MI0006311_5'Flank|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3698	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						AGACGGTAGGCGTGCCCATGG	0.642												
TRAP1	10131	broad.mit.edu	37	16	3724366	3724366	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:3724366G>A	uc002cvt.3	-	9	1107	c.1018C>T	c.(1018-1020)CGC>TGC	p.R340C	TRAP1_uc002cvs.2_Missense_Mutation_p.R131C|TRAP1_uc010uxf.1_Missense_Mutation_p.R287C	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	340					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				AAGATGCTGCGGATGTTGAGC	0.607												
SEC14L5	9717	broad.mit.edu	37	16	5064914	5064914	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:5064914C>T	uc002cye.2	+	16	2214	c.2034C>T	c.(2032-2034)GCC>GCT	p.A678A		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	678	Ser-rich.					integral to membrane|intracellular	transporter activity				0						AGCTCAGCGCCGCCACCTCGT	0.662												
GP2	2813	broad.mit.edu	37	16	20335179	20335179	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:20335179C>A	uc002dgv.2	-	3	577	c.494G>T	c.(493-495)CGG>CTG	p.R165L	GP2_uc002dgw.2_Missense_Mutation_p.R165L|GP2_uc002dgx.2_Intron|GP2_uc002dgy.2_Intron	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	165						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						GCCTTCCAACCGGTACACATG	0.577												
NKD1	85407	broad.mit.edu	37	16	50642255	50642255	+	Silent	SNP	C	C	T	rs115028583	by1000genomes	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:50642255C>T	uc002egg.1	+	4	467	c.243C>T	c.(241-243)GAC>GAT	p.D81D		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	81					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		AAGAGGAGGACGACTTTCGGC	0.602												
NDRG4	65009	broad.mit.edu	37	16	58538551	58538551	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:58538551G>T	uc002eno.2	+	5	476	c.370G>T	c.(370-372)GCA>TCA	p.A124S	NDRG4_uc002enk.2_Missense_Mutation_p.A156S|NDRG4_uc002enm.2_Missense_Mutation_p.A176S|NDRG4_uc010vif.1_Missense_Mutation_p.A156S|NDRG4_uc010cdk.2_Missense_Mutation_p.A142S|NDRG4_uc010vig.1_Missense_Mutation_p.A154S|NDRG4_uc010vih.1_Missense_Mutation_p.A69S|NDRG4_uc010vii.1_Missense_Mutation_p.A142S|NDRG4_uc002enp.2_Missense_Mutation_p.A124S|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	124					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						GGCCAAGTTTGCAGTGAGTCT	0.607												
MLKL	197259	broad.mit.edu	37	16	74716642	74716642	+	Missense_Mutation	SNP	A	A	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:74716642A>C	uc002fdb.2	-	6	1304	c.863T>G	c.(862-864)CTC>CGC	p.L288R	MLKL_uc002fdc.2_Intron	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	288	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						CAGGGTCCCGAGTTCACAGTA	0.557												
C16orf46	123775	broad.mit.edu	37	16	81097557	81097557	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:81097557C>A	uc002fgc.3	-	3	263	c.4G>T	c.(4-6)GAT>TAT	p.D2Y	C16orf46_uc010chf.2_Missense_Mutation_p.D2Y|C16orf46_uc010vno.1_Intron	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	2											0						TGACAGAGATCCATTACTGTG	0.294												
KRT36	8689	broad.mit.edu	37	17	39645762	39645762	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:39645762C>T	uc002hwt.2	-	1	355	c.355G>A	c.(355-357)GCG>ACG	p.A119T		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	119	Rod.|Coil 1A.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				TCCAGCTCCGCGTTCTCCCGC	0.572												
CD300A	11314	broad.mit.edu	37	17	72470705	72470705	+	Silent	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:72470705G>A	uc002jkv.2	+	3	735	c.414G>A	c.(412-414)GCG>GCA	p.A138A	CD300A_uc002jkw.2_Silent_p.A25A|CD300A_uc010dfr.2_Silent_p.A25A|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	138	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	receptor activity	p.A138A(1)		ovary(1)|skin(1)	2						GTATCACTGCGGCCAAGACCT	0.547												
SEC14L1	6397	broad.mit.edu	37	17	75186883	75186883	+	Splice_Site	SNP	A	A	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:75186883A>T	uc002jto.2	+	4	331	c.64_splice	c.e4-2	p.A22_splice	SEC14L1_uc010dhc.2_Splice_Site_p.A22_splice|SEC14L1_uc010wth.1_Splice_Site_p.A22_splice|SEC14L1_uc002jtm.2_Splice_Site_p.A22_splice|SEC14L1_uc010wti.1_Splice_Site	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a						transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						TTAAATTTATAGGCCTATGAA	0.483												
PIK3C3	5289	broad.mit.edu	37	18	39570432	39570432	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:39570432C>T	uc002lap.2	+	6	686	c.628C>T	c.(628-630)CGA>TGA	p.R210*	PIK3C3_uc010xcl.1_Nonsense_Mutation_p.R147*	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	210					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						GAGTGAAAAACGAAGTTCTAA	0.284										TSP Lung(28;0.18)		
ST8SIA5	29906	broad.mit.edu	37	18	44272196	44272196	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:44272196C>G	uc002lcj.1	-	3	815	c.247G>C	c.(247-249)GAC>CAC	p.D83H	ST8SIA5_uc002lci.1_5'UTR|ST8SIA5_uc010xcy.1_Missense_Mutation_p.D119H|ST8SIA5_uc010xcz.1_Missense_Mutation_p.D52H|ST8SIA5_uc010dno.1_Missense_Mutation_p.D119H	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	83	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						TTCCACCTGTCGAACAGCTCT	0.527												
SMAD4	4089	broad.mit.edu	37	18	48593393	48593393	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:48593393C>G	uc010xdp.1	+	10	1682	c.1144C>G	c.(1144-1146)CAC>GAC	p.H382D	SMAD4_uc002lfb.3_Missense_Mutation_p.H227D	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	382	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CCTAAGGTTGCACATAGGCAA	0.333									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia			
NETO1	81832	broad.mit.edu	37	18	70417501	70417501	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:70417501T>G	uc002lkw.2	-	9	1621	c.1337A>C	c.(1336-1338)AAC>ACC	p.N446T	NETO1_uc002lkx.1_Missense_Mutation_p.N445T|NETO1_uc002lky.1_Missense_Mutation_p.N446T	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	446	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TGTGCTGAGGTTACTGCGGCT	0.463												
ARID3A	1820	broad.mit.edu	37	19	971927	971927	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:971927C>G	uc002lql.2	+	9	1934	c.1644C>G	c.(1642-1644)AAC>AAG	p.N548K		NM_005224	NP_005215	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT- like)	548	Important for cytoplasmic localization (By similarity).					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTCCCAACAAAGGAggcg	0.532												
ADAMTS10	81794	broad.mit.edu	37	19	8668685	8668685	+	Silent	SNP	T	T	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:8668685T>C	uc002mkj.1	-	5	793	c.519A>G	c.(517-519)GAA>GAG	p.E173E	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	173					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GTGGTCCACTTTCCTCCGGGC	0.597												
ZNF491	126069	broad.mit.edu	37	19	11917976	11917976	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:11917976G>T	uc002mso.1	+	3	1493	c.1208G>T	c.(1207-1209)AGA>ATA	p.R403I		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	403	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ATACATGAAAGAATTCACACT	0.368												
TSHZ3	57616	broad.mit.edu	37	19	31769087	31769087	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:31769087G>T	uc002nsy.3	-	2	1677	c.1612C>A	c.(1612-1614)CAG>AAG	p.Q538K		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	538					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GTGCCGTTCTGGGCCTTGTTG	0.532												
TRPM4	54795	broad.mit.edu	37	19	49661469	49661469	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:49661469C>A	uc002pmw.2	+	2	117	c.45C>A	c.(43-45)TTC>TTA	p.F15L	TRPM4_uc010emu.2_Missense_Mutation_p.F15L|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_5'UTR|TRPM4_uc010emv.2_Missense_Mutation_p.F15L|TRPM4_uc010yal.1_5'UTR|HRC_uc002pmv.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	15	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CCAAGATCTTCAAGAAGAAGA	0.602												
VRK3	51231	broad.mit.edu	37	19	50498471	50498471	+	Silent	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:50498471G>A	uc002prg.2	-	8	839	c.741C>T	c.(739-741)TTC>TTT	p.F247F	VRK3_uc002prh.1_Silent_p.F247F|VRK3_uc002pri.1_Silent_p.F197F|VRK3_uc010ens.2_Silent_p.F247F|VRK3_uc010ybl.1_Silent_p.F197F|VRK3_uc010ybm.1_Intron|VRK3_uc002prj.1_Silent_p.F197F|VRK3_uc002prk.1_Silent_p.F247F|VRK3_uc010ent.1_Silent_p.F3F|VRK3_uc002prl.2_Silent_p.F247F|VRK3_uc010ybn.1_Missense_Mutation_p.S225L	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	247	Protein kinase.					nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GGTGAACACCGAAACCCATGC	0.562												
LRRC4B	94030	broad.mit.edu	37	19	51022345	51022345	+	Silent	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:51022345G>A	uc002pss.2	-	3	762	c.625C>T	c.(625-627)CTG>TTG	p.L209L		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	209	Extracellular (Potential).|LRR 6.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGGTAGCGCAGGTTGACCAGC	0.667												
SIGLEC14	100049587	broad.mit.edu	37	19	52149516	52149516	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:52149516C>A	uc002pxf.3	-	2	535	c.415G>T	c.(415-417)GTG>TTG	p.V139L		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	139	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		ATACCTGTCACCTCCAAGTTC	0.557												
LILRA3	11026	broad.mit.edu	37	19	54802027	54802027	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:54802027C>T	uc002qfd.2	-	6	1226	c.1161G>A	c.(1159-1161)GTG>GTA	p.V387V	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.V323V	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	387	Ig-like C2-type 4.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGCCGAGGTCACAGGACTCA	0.587												
FCAR	2204	broad.mit.edu	37	19	55396777	55396777	+	Silent	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:55396777G>A	uc002qhr.1	+	3	398	c.201G>A	c.(199-201)ACG>ACA	p.T67T	FCAR_uc002qhq.2_Silent_p.T67T|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.T40T|FCAR_uc010esi.1_Silent_p.T40T|FCAR_uc002qhu.1_Silent_p.T67T|FCAR_uc002qhv.1_Silent_p.T67T|FCAR_uc002qhw.1_Silent_p.T55T|FCAR_uc002qhx.1_Silent_p.T55T|FCAR_uc002qhy.1_Silent_p.T55T|FCAR_uc002qhz.1_Silent_p.T55T|FCAR_uc002qia.1_Intron	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	67	Extracellular (Potential).|Ig-like C2-type 1.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		AAAACTCCACGTACCGAGAGA	0.488												
NCR1	9437	broad.mit.edu	37	19	55421410	55421410	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:55421410G>A	uc002qib.2	+	5	705	c.667G>A	c.(667-669)GAC>AAC	p.D223N	NCR1_uc002qic.2_Missense_Mutation_p.D223N|NCR1_uc002qie.2_Missense_Mutation_p.D223N|NCR1_uc002qid.2_Missense_Mutation_p.D128N|NCR1_uc002qif.2_Missense_Mutation_p.D128N|NCR1_uc010esj.2_Missense_Mutation_p.D116N	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	223	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TGCACCTGAAGACCCCACCTT	0.438												
TXNDC9	10190	broad.mit.edu	37	2	99944024	99944024	+	Silent	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:99944024G>A	uc002szz.2	-	3	473	c.282C>T	c.(280-282)TGC>TGT	p.C94C	TXNDC9_uc010yvp.1_Silent_p.C111C|TXNDC9_uc002taa.1_Silent_p.C94C	NM_005783	NP_005774	O14530	TXND9_HUMAN	thioredoxin domain containing 9	94	Thioredoxin.				cell redox homeostasis		protein binding				0						TGTAGAAATGGCAAACCACAT	0.378												
THSD7B	80731	broad.mit.edu	37	2	138169203	138169203	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:138169203G>A	uc002tva.1	+	13	2627	c.2627G>A	c.(2626-2628)TGC>TAC	p.C876Y	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.C766Y	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AAGGAGAAATGCCAGGATTCT	0.373												
ZEB2	9839	broad.mit.edu	37	2	145162506	145162506	+	Silent	SNP	G	G	A	rs138859323	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:145162506G>A	uc002tvu.2	-	5	969	c.489C>T	c.(487-489)ATC>ATT	p.I163I	ZEB2_uc002tvv.2_Silent_p.I157I|ZEB2_uc010zbm.1_Silent_p.I134I|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.I192I	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	163						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGTACTCCTCGATGCTGACTG	0.478												
NEUROD1	4760	broad.mit.edu	37	2	182542645	182542645	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:182542645C>T	uc002uof.2	-	2	1179	c.943G>A	c.(943-945)GGA>AGA	p.G315R	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	315					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			AAGATTGATCCGTGGCTTTGG	0.512												
DNAH7	56171	broad.mit.edu	37	2	196737066	196737066	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:196737066G>A	uc002utj.3	-	40	6642	c.6541C>T	c.(6541-6543)CGT>TGT	p.R2181C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2181	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAGAAATCACGGAGGTTGAAC	0.393												
PLCL1	5334	broad.mit.edu	37	2	198948639	198948639	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:198948639G>A	uc010fsp.2	+	2	689	c.398G>A	c.(397-399)CGT>CAT	p.R133H	PLCL1_uc002uuv.3_Missense_Mutation_p.R54H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	133	PH.|Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	ATTTACAACCGTTTTTTCACT	0.443												
ERBB4	2066	broad.mit.edu	37	2	212248608	212248608	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:212248608T>G	uc002veg.1	-	28	3757	c.3659A>C	c.(3658-3660)GAG>GCG	p.E1220A	ERBB4_uc002veh.1_Missense_Mutation_p.E1204A|ERBB4_uc010zji.1_Missense_Mutation_p.E1210A|ERBB4_uc010zjj.1_Missense_Mutation_p.E1194A	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1220	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CTTCAGGTACTCAGCTTTTCC	0.502										TSP Lung(8;0.080)		
SPEG	10290	broad.mit.edu	37	2	220329225	220329225	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:220329225C>T	uc010fwg.2	+	9	2776	c.2776C>T	c.(2776-2778)CGG>TGG	p.R926W	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Missense_Mutation_p.R134W|SPEG_uc002vln.1_Missense_Mutation_p.R134W|SPEG_uc002vlp.1_Missense_Mutation_p.R134W|SPEG_uc002vlq.2_Missense_Mutation_p.R77W	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	926	Ig-like 3.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGGGCTGTGCCGGCTGCGGAT	0.647												
SLC19A3	80704	broad.mit.edu	37	2	228566967	228566967	+	Missense_Mutation	SNP	C	C	A	rs121917882		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:228566967C>A	uc002vpi.2	-	2	157	c.68G>T	c.(67-69)GGT>GTT	p.G23V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_5'UTR	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	23	Helical; (Potential).		G -> V (in BBGD).		thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	GGAGAAAAAACCAAATAAGCA	0.393												
PIWIL3	440822	broad.mit.edu	37	22	25153973	25153973	+	Missense_Mutation	SNP	T	T	C	rs142994368	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr22:25153973T>C	uc003abd.1	-	4	674	c.257A>G	c.(256-258)CAT>CGT	p.H86R	PIWIL3_uc011ajx.1_5'UTR|PIWIL3_uc011ajy.1_5'UTR|PIWIL3_uc010gut.1_Missense_Mutation_p.H86R	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	86					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						GGGCGCTGTATGCAACCCAGC	0.438												
CHL1	10752	broad.mit.edu	37	3	407660	407660	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:407660A>G	uc003bou.2	+	14	1836	c.1565A>G	c.(1564-1566)AAG>AGG	p.K522R	CHL1_uc003bot.2_Missense_Mutation_p.K538R|CHL1_uc003bow.1_Missense_Mutation_p.K522R|CHL1_uc011asi.1_Missense_Mutation_p.K538R|uc003box.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	522	Ig-like C2-type 6.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GTTTCTCCTAAGAATCCTCGT	0.338												
GRM7	2917	broad.mit.edu	37	3	7456790	7456790	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:7456790T>G	uc003bqm.2	+	5	1388	c.1114T>G	c.(1114-1116)TTC>GTC	p.F372V	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.F372V|GRM7_uc003bql.2_Missense_Mutation_p.F372V|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	372	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GGAGGAAAACTTCAACTGCAA	0.388												
IL17RC	84818	broad.mit.edu	37	3	9971770	9971770	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:9971770C>A	uc003bua.2	+	14	1664	c.1428C>A	c.(1426-1428)GAC>GAA	p.D476E	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcs.2_Missense_Mutation_p.D380E|IL17RC_uc003btz.2_Missense_Mutation_p.D405E|IL17RC_uc011atp.1_Missense_Mutation_p.D244E|IL17RC_uc003bud.2_Intron|IL17RC_uc003bub.2_Missense_Mutation_p.D390E|IL17RC_uc010hct.2_Missense_Mutation_p.D405E|IL17RC_uc010hcu.2_Missense_Mutation_p.D388E|IL17RC_uc010hcv.2_Missense_Mutation_p.D373E|IL17RC_uc011atq.1_Missense_Mutation_p.D390E|IL17RC_uc003buc.2_5'UTR|IL17RC_uc003bue.2_Missense_Mutation_p.D41E	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	476	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GCCCCCAGGACAACAGATCCC	0.587												
RFTN1	23180	broad.mit.edu	37	3	16475457	16475457	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:16475457G>T	uc003cay.2	-	3	515	c.233C>A	c.(232-234)TCG>TAG	p.S78*	RFTN1_uc010hes.2_Nonsense_Mutation_p.S42*	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	78						plasma membrane				ovary(3)|central_nervous_system(1)	4						GGCCGCCAGCGAGAAGCCCTG	0.652												
GRM2	2912	broad.mit.edu	37	3	51749520	51749520	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:51749520C>T	uc010hlv.2	+	4	1970	c.1731C>T	c.(1729-1731)CTC>CTT	p.L577L	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	577	Helical; Name=1; (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TCGCCTGCCTCGGTGCCCTGG	0.637												
POLQ	10721	broad.mit.edu	37	3	121228447	121228447	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:121228447C>A	uc003eee.3	-	12	2049	c.1920G>T	c.(1918-1920)AAG>AAT	p.K640N		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	640					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAACAAAGCCCTTCATTGCTC	0.343								DNA_polymerases_(catalytic_subunits)				
XRN1	54464	broad.mit.edu	37	3	142031582	142031582	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:142031582G>A	uc003eus.2	-	41	4743	c.4676C>T	c.(4675-4677)TCG>TTG	p.S1559L	XRN1_uc010huu.2_Missense_Mutation_p.S1013L|XRN1_uc003eut.2_Missense_Mutation_p.S1546L|XRN1_uc003euu.2_Missense_Mutation_p.S1547L	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1559					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						GAGATGAGACGACGAAGGCAT	0.443												
P2RY1	5028	broad.mit.edu	37	3	152554180	152554180	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:152554180C>T	uc003ezq.2	+	1	1445	c.609C>T	c.(607-609)TAC>TAT	p.Y203Y		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	203	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TCACCTGTTACGACACCACCT	0.537												
CCDC50	152137	broad.mit.edu	37	3	191107374	191107374	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:191107374C>T	uc003fsw.2	+	10	1474	c.884C>T	c.(883-885)TCA>TTA	p.S295L	CCDC50_uc003fsv.2_Missense_Mutation_p.S471L	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	295						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		TTCTCAAAATCAGAGTCCTCT	0.388												
SLC9A3	6550	broad.mit.edu	37	5	488520	488520	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:488520C>T	uc003jbe.2	-	3	698	c.586G>A	c.(586-588)GTC>ATC	p.V196I	SLC9A3_uc011clx.1_Missense_Mutation_p.V196I	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	196	Helical; Name=F/M5A; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACGGCCAGGACGGCCACCGGG	0.642												
ENC1	8507	broad.mit.edu	37	5	73931384	73931384	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:73931384C>T	uc003kdc.3	-	2	2058	c.927G>A	c.(925-927)AAG>AAA	p.K309K	ENC1_uc011css.1_Silent_p.K236K	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	309	Kelch 1.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		CCAGATACAACTTGTCACACA	0.507												
DMGDH	29958	broad.mit.edu	37	5	78338268	78338268	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:78338268C>A	uc003kfs.2	-	7	1037	c.1031G>T	c.(1030-1032)CGA>CTA	p.R344L	DMGDH_uc011cte.1_Missense_Mutation_p.R194L|DMGDH_uc011ctf.1_Missense_Mutation_p.R143L|DMGDH_uc011ctg.1_Intron	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	344					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TTCCATGATTCGATCTAGATC	0.428												
DMXL1	1657	broad.mit.edu	37	5	118484637	118484637	+	Missense_Mutation	SNP	A	A	T	rs149431940	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:118484637A>T	uc003ksd.2	+	18	3296	c.3115A>T	c.(3115-3117)AGT>TGT	p.S1039C	DMXL1_uc010jcl.1_Missense_Mutation_p.S1039C	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1039										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GAGCAATAGTAGTATAACTGT	0.398												
PCDHB9	56127	broad.mit.edu	37	5	140567301	140567301	+	Missense_Mutation	SNP	G	G	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:140567301G>C	uc003liw.1	+	1	409	c.409G>C	c.(409-411)GAG>CAG	p.E137Q		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	137	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGCACAAAGAGATGGTCTT	0.403												
TCERG1	10915	broad.mit.edu	37	5	145838886	145838886	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:145838886C>T	uc003lob.2	+	4	918	c.878C>T	c.(877-879)GCG>GTG	p.A293V	TCERG1_uc003loc.2_Missense_Mutation_p.A293V|TCERG1_uc011dbt.1_Missense_Mutation_p.A293V	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	293	Thr-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACTTCAGTTGCGCAGACAGTA	0.463												
FKSG83	83954	broad.mit.edu	37	6	27293549	27293549	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:27293549C>T	uc010jqt.2	+	1	972	c.488C>T	c.(487-489)TCC>TTC	p.S163F	FKSG83_uc010jqs.1_3'UTR	NM_032030	NP_114419	Q3KNW7	Q3KNW7_HUMAN	FKSG83	163						integral to membrane	pheromone receptor activity				0						ATGATTATTTCCCCCTGCTTA	0.294												
VARS2	57176	broad.mit.edu	37	6	30890881	30890881	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:30890881C>T	uc003nsc.1	+	23	2818	c.2186C>T	c.(2185-2187)GCG>GTG	p.A729V	VARS2_uc011dmx.1_Missense_Mutation_p.A729V|VARS2_uc011dmy.1_Missense_Mutation_p.A589V|VARS2_uc011dmz.1_Missense_Mutation_p.A759V|VARS2_uc011dna.1_Missense_Mutation_p.A727V|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_Missense_Mutation_p.A167V|VARS2_uc010jsg.1_Missense_Mutation_p.A101V|VARS2_uc010jsh.1_5'UTR	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	729					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						TCCCTTCCAGCGGGCGACTTG	0.582												
C6orf27	80737	broad.mit.edu	37	6	31733757	31733757	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:31733757A>G	uc011dog.1	-	16	2640	c.2402T>C	c.(2401-2403)GTG>GCG	p.V801A		NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	801						extracellular region				ovary(3)	3						CACCATCACCACGGAATCCGG	0.647												
TRERF1	55809	broad.mit.edu	37	6	42227349	42227349	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:42227349G>A	uc003osd.2	-	9	2560	c.1997C>T	c.(1996-1998)CCG>CTG	p.P666L	TRERF1_uc011duq.1_Missense_Mutation_p.P583L|TRERF1_uc003osb.2_Missense_Mutation_p.P422L|TRERF1_uc003osc.2_Missense_Mutation_p.P422L|TRERF1_uc003ose.2_Missense_Mutation_p.P686L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	666	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GTAGGAGGGCGGCGGCGGGAT	0.672												
ENPP5	59084	broad.mit.edu	37	6	46135702	46135702	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:46135702G>A	uc003oxz.1	-	2	506	c.298C>T	c.(298-300)CGG>TGG	p.R100W	ENPP5_uc003oya.1_Missense_Mutation_p.R100W|ENPP5_uc011dvz.1_Missense_Mutation_p.R6W|ENPP5_uc010jzc.1_Missense_Mutation_p.R100W	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	100						extracellular region|integral to membrane	hydrolase activity				0						GATTTGTTCCGAATAGGATCA	0.378												
KIAA1586	57691	broad.mit.edu	37	6	56918804	56918804	+	Missense_Mutation	SNP	T	T	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:56918804T>C	uc003pdj.2	+	4	1677	c.1507T>C	c.(1507-1509)TAT>CAT	p.Y503H	KIAA1586_uc011dxm.1_Missense_Mutation_p.Y476H	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	503							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TCCTATATTATATATGCATTT	0.348												
RIMS1	22999	broad.mit.edu	37	6	72678732	72678732	+	Missense_Mutation	SNP	A	A	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:72678732A>G	uc003pga.2	+	2	288	c.211A>G	c.(211-213)AGA>GGA	p.R71G		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	71	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAAAACACCAAGAAATGCTGA	0.453												
SNX14	57231	broad.mit.edu	37	6	86303411	86303411	+	Missense_Mutation	SNP	C	C	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:86303411C>G	uc003pkr.2	-	1	219	c.26G>C	c.(25-27)GGG>GCG	p.G9A	SNX14_uc011dzg.1_Intron|SNX14_uc003pks.2_Missense_Mutation_p.G9A|SNX14_uc003pkt.2_Missense_Mutation_p.G9A	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	9					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CAGCTTCTGCCCCATCGTCCG	0.672												
EPDR1	54749	broad.mit.edu	37	7	37989889	37989889	+	Missense_Mutation	SNP	C	C	T	rs147990215	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:37989889C>T	uc003tfp.2	+	3	945	c.926C>T	c.(925-927)ACG>ATG	p.T309M	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Missense_Mutation_p.T128M	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	189					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						ATATTGTCTACGCGGTTTTTT	0.463												
TNS3	64759	broad.mit.edu	37	7	47343060	47343060	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:47343060G>T	uc003tnv.2	-	22	3312	c.2945C>A	c.(2944-2946)TCC>TAC	p.S982Y	TNS3_uc003tnw.2_Missense_Mutation_p.S982Y	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	982						focal adhesion	protein binding			ovary(4)	4						CAGCACTGGGGAGTCCTTCCT	0.672												
FZD1	8321	broad.mit.edu	37	7	90895695	90895695	+	Silent	SNP	T	T	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:90895695T>C	uc003ula.2	+	1	1913	c.1500T>C	c.(1498-1500)TTT>TTC	p.F500F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	500	Helical; Name=5; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGTACCTGTTTATCGGCACGT	0.602												
WDR91	29062	broad.mit.edu	37	7	134889047	134889047	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:134889047C>T	uc003vsp.2	-	6	926	c.864G>A	c.(862-864)TCG>TCA	p.S288S	WDR91_uc010lmq.2_5'UTR|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	288										breast(2)|ovary(1)|skin(1)	4						CTTTCTTGGCCGAGCTCTGAG	0.592												
TMEM213	155006	broad.mit.edu	37	7	138487766	138487766	+	Missense_Mutation	SNP	C	C	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:138487766C>A	uc010lna.2	+	3	387	c.276C>A	c.(274-276)GAC>GAA	p.D92E	TMEM213_uc010lnb.2_Missense_Mutation_p.D91E	NM_001085429	NP_001078898	A2RRL7	TM213_HUMAN	transmembrane protein 213	92	Cytoplasmic (Potential).					integral to membrane					0						TCTGTGTGGACAAACTGATGA	0.587												
SLC4A2	6522	broad.mit.edu	37	7	150772385	150772385	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:150772385G>A	uc003wit.3	+	20	3347	c.3091G>A	c.(3091-3093)GGC>AGC	p.G1031S	SLC4A2_uc011kve.1_Missense_Mutation_p.G1022S|SLC4A2_uc003wiu.3_Missense_Mutation_p.G1017S|SLC4A2_uc003wiv.3_Missense_Mutation_p.G225S|uc011kvf.1_Silent_p.A167A	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1031	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAAGGGCTCCGGCTTCCACCT	0.642												
DDHD2	23259	broad.mit.edu	37	8	38095671	38095671	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:38095671G>A	uc003xlb.2	+	5	943	c.566G>A	c.(565-567)GGT>GAT	p.G189D	DDHD2_uc003xla.2_Missense_Mutation_p.G189D|DDHD2_uc003xlc.2_Missense_Mutation_p.G189D|DDHD2_uc011lbl.1_Intron	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	189					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			ACGGAGCAGGGTCGACCAAGA	0.403												
RBM12B	389677	broad.mit.edu	37	8	94746335	94746335	+	Silent	SNP	T	T	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:94746335T>C	uc003yfz.2	-	3	2497	c.2304A>G	c.(2302-2304)CCA>CCG	p.P768P		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	768							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TGAAATGCTCTGGGGGTGGCC	0.677												
RBM12B	389677	broad.mit.edu	37	8	94746349	94746349	+	Silent	SNP	T	T	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:94746349T>G	uc003yfz.2	-	3	2483	c.2290A>C	c.(2290-2292)AGG>CGG	p.R764R		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	764							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGTGGCCGCCTGAAGTGCTCT	0.677												
TSPYL5	85453	broad.mit.edu	37	8	98289373	98289373	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:98289373G>A	uc003yhy.2	-	1	804	c.700C>T	c.(700-702)CGA>TGA	p.R234*		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	234					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					TGCTGCAGTCGCAACTGCCCA	0.567												
CSMD3	114788	broad.mit.edu	37	8	113332148	113332148	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:113332148C>T	uc003ynu.2	-	46	7387	c.7228G>A	c.(7228-7230)GAT>AAT	p.D2410N	CSMD3_uc003yns.2_Missense_Mutation_p.D1612N|CSMD3_uc003ynt.2_Missense_Mutation_p.D2370N|CSMD3_uc011lhx.1_Missense_Mutation_p.D2306N|CSMD3_uc003ynw.1_Missense_Mutation_p.D121N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2410	Extracellular (Potential).|Sushi 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATTCATCATCTTCCGTCAAA	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CYLC2	1539	broad.mit.edu	37	9	105767544	105767544	+	Missense_Mutation	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:105767544G>A	uc004bbs.2	+	5	701	c.631G>A	c.(631-633)GGA>AGA	p.G211R		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	211	3 X approximate tandem repeats.|31 X 3 AA repeats of K-K-X.|2.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				AGGTGAAAAAGGAGGTACAGA	0.279												
SVEP1	79987	broad.mit.edu	37	9	113173397	113173397	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:113173397C>T	uc010mtz.2	-	37	6931	c.6594G>A	c.(6592-6594)ACG>ACA	p.T2198T	SVEP1_uc010mty.2_Silent_p.T124T	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2198	Sushi 13.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCGGGTGGCACGTCGGTATAG	0.522												
CERCAM	51148	broad.mit.edu	37	9	131186739	131186739	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:131186739C>T	uc004buz.3	+	5	1010	c.612C>T	c.(610-612)CGC>CGT	p.R204R	CERCAM_uc004buy.1_Silent_p.R126R|CERCAM_uc010mxz.2_Silent_p.R126R|CERCAM_uc010mya.1_Silent_p.R45R	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	204					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						ACCGCCAGCGCCGGGGCTGCT	0.647												
COL5A1	1289	broad.mit.edu	37	9	137708924	137708924	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:137708924G>T	uc004cfe.2	+	53	4557	c.4175G>T	c.(4174-4176)AGG>ATG	p.R1392M		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1392	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCAGGAAAAAGGGTAAATAAT	0.572												
CCNB3	85417	broad.mit.edu	37	X	50085293	50085293	+	Silent	SNP	A	A	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:50085293A>G	uc004dox.3	+	9	3907	c.3609A>G	c.(3607-3609)TTA>TTG	p.L1203L	CCNB3_uc004doy.2_Silent_p.L1203L|CCNB3_uc004doz.2_Silent_p.L99L|CCNB3_uc010njq.2_Silent_p.L95L|CCNB3_uc004dpa.2_Silent_p.L42L	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1203					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					AGGATAAGTTACAACTCCTTG	0.473												
HEPH	9843	broad.mit.edu	37	X	65483491	65483491	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:65483491T>G	uc011moz.1	+	20	3274	c.3214T>G	c.(3214-3216)TTA>GTA	p.L1072V	HEPH_uc004dwn.2_Missense_Mutation_p.L1072V|HEPH_uc004dwo.2_Missense_Mutation_p.L802V|HEPH_uc010nkr.2_Missense_Mutation_p.L880V|HEPH_uc011mpa.1_Missense_Mutation_p.L1072V	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1069	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						ACCAGAACACTTAAGCCCTCT	0.438												
AR	367	broad.mit.edu	37	X	66765882	66765882	+	Silent	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:66765882C>T	uc004dwu.1	+	1	2009	c.894C>T	c.(892-894)AGC>AGT	p.S298S	AR_uc011mpd.1_Silent_p.S298S|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Silent_p.S298S	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	296	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TAGACGACAGCGCAGGCAAGA	0.572									Androgen_Insensitivity_Syndrome			
KLHL4	56062	broad.mit.edu	37	X	86877278	86877278	+	Missense_Mutation	SNP	T	T	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:86877278T>G	uc004efb.2	+	5	1174	c.992T>G	c.(991-993)CTT>CGT	p.L331R	KLHL4_uc004efa.2_Missense_Mutation_p.L331R	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	331						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						ATTTCAAAACTTCTGTGCAGT	0.398												
AKAP14	158798	broad.mit.edu	37	X	119037549	119037549	+	Silent	SNP	G	G	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:119037549G>A	uc004ese.2	+	4	399	c.261G>A	c.(259-261)TCG>TCA	p.S87S	AKAP14_uc004esd.2_Silent_p.S87S|AKAP14_uc004esf.2_Silent_p.S87S	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	87						cytoplasm					0						AATATTTTTCGGTAAGTTAGG	0.413												
ZNF75D	7626	broad.mit.edu	37	X	134426308	134426308	+	Missense_Mutation	SNP	G	G	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:134426308G>T	uc004eyp.2	-	4	3158	c.503C>A	c.(502-504)CCA>CAA	p.P168Q	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'UTR|ZNF75D_uc004eyo.2_Intron	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	168					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CACACCCATTGGTTGGGGCTC	0.507												
PNMA5	114824	broad.mit.edu	37	X	152159886	152159886	+	Missense_Mutation	SNP	C	C	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:152159886C>T	uc010ntw.2	-	3	596	c.257G>A	c.(256-258)GGT>GAT	p.G86D	PNMA5_uc004fha.3_Missense_Mutation_p.G86D|PNMA5_uc010ntx.2_Missense_Mutation_p.G86D|PNMA5_uc004fgy.3_Missense_Mutation_p.G86D	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	86					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ccaggagccaccctttcctgg	0												
ABCC9	10060	broad.mit.edu	37	12	22059168	22059169	+	Frame_Shift_Ins	INS	-	-	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:22059168_22059169insT	uc001rfi.1	-	10	1529_1530	c.1509_1510insA	c.(1507-1512)AAACTTfs	p.K503fs	ABCC9_uc001rfh.2_Frame_Shift_Ins_p.K503fs|ABCC9_uc001rfj.1_Frame_Shift_Ins_p.K503fs	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	503_504	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AATTTTAGAAGTTTGATGCCTT	0.337												
ZDHHC22	283576	broad.mit.edu	37	14	77600151	77600151	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:77600151delC	uc010asp.2	-	3	870	c.667delG	c.(667-669)GTGfs	p.V223fs		NM_174976	NP_777636	Q8N966	ZDH22_HUMAN	zinc finger, DHHC domain containing 22	223						integral to membrane	acyltransferase activity|zinc ion binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		CTCACTGCCACCCCCTTCCGC	0.652												
IRF2BP2	359948	broad.mit.edu	37	1	234743438	234743439	+	Frame_Shift_Ins	INS	-	-	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:234743437_234743438T>TG	uc001hwg.3	-	1	1240_1241	c.1209_1210A>CA	c.(1207-1212)cccactfs	p.P403fs	IRF2BP2_uc009xfw.3_Frame_Shift_Ins_p.P13fs|IRF2BP2_uc001hwf.3_Frame_Shift_Ins_p.P387fs	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	Homo sapiens interferon regulatory factor 2 binding protein 2 (IRF2BP2), transcript variant 1, mRNA.	403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			GGTGAGGCAGTGGGTGGTGGCG	0.599												
MED23	9439	broad.mit.edu	37	6	131948549	131948549	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:131948548_131948548AC>A	uc003qcs.1	-	2	321	c.147_147GT>T	c.(145-147)ggtfs	p.G49fs	ENPP3_uc010kfn.1_5'Flank|ENPP3_uc003qcu.4_5'Flank|MED23_uc003qcq.3_Frame_Shift_Del_p.G49fs|MED23_uc003qct.1_Frame_Shift_Del_p.G49fs|MED23_uc011ecb.1_Non-coding_Transcript	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	Homo sapiens mediator complex subunit 23 (MED23), transcript variant 1, mRNA.	49					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GAGAAAGACCACCCCAAAACT	0.318												
PIK3C2G	5288	broad.mit.edu	37	12	18491390	18491391	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:18491389_18491390T>TA	uc001rdt.3	+	8	1418_1419	c.1302_1303T>TA	c.(1300-1305)gttaaafs	p.V434fs	PIK3C2G_uc010sia.2_Non-coding_Transcript|PIK3C2G_uc010sib.2_Frame_Shift_Ins_p.V434fs|PIK3C2G_uc010sic.2_Frame_Shift_Ins_p.V212fs	NM_004570	NP_004561	O75747	P3C2G_HUMAN	Homo sapiens phosphoinositide-3-kinase, class 2, gamma polypeptide (PIK3C2G), mRNA.	434					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TTGAAGAAGTTAAAAAAATATG	0.312												
ABCC9	10060	broad.mit.edu	37	12	22059169	22059170	+	Frame_Shift_Ins	INS	-	-	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:22059168_22059169G>GT	uc001rfh.3	-	9	1529_1530	c.1509_1510C>AC	c.(1507-1512)aaacttfs	p.K503fs	ABCC9_uc001rfi.1_Frame_Shift_Ins_p.K503fs	NM_020297	NP_064693	O60706	ABCC9_HUMAN	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (ABCC9), transcript variant SUR2B, mRNA.	503	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AATTTTAGAAGTTTGATGCCTT	0.337												
TP53	7157	broad.mit.edu	37	17	7578475	7578476	+	Frame_Shift_Ins	INS	-	-	G	rs137852790		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:7578474_7578475C>CG	uc002gim.2	-	4	649_650	c.455_456G>CG	c.(454-456)ccgfs	p.P152fs	TP53_uc002gig.1_Frame_Shift_Ins_p.P152fs|TP53_uc002gih.3_Frame_Shift_Ins_p.P152fs|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Frame_Shift_Ins_p.P20fs|TP53_uc010cnf.1_Frame_Shift_Ins_p.P20fs|TP53_uc002gii.1_Frame_Shift_Ins_p.P20fs|TP53_uc010cni.1_Frame_Shift_Ins_p.P152fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.P152fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P152fs|TP53_uc010cnj.1_Non-coding_Transcript|TP53_uc002gin.2_Frame_Shift_Ins_p.P59fs|TP53_uc002gio.2_Frame_Shift_Ins_p.P20fs|TP53_uc010vug.2_Frame_Shift_Ins_p.P113fs	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	152	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(129)|p.P151S(66)|p.P151H(27)|p.P152fs*18(23)|p.P152S(22)|p.P152R(14)|p.P151T(14)|p.P151P(12)|p.P152P(10)|p.P152fs*14(10)|p.P153fs*28(9)|p.P151A(9)|p.P152Q(8)|p.0?(8)|p.P152T(7)|p.P151L(7)|p.P151fs*30(7)|p.P151R(7)|p.T150fs*16(6)|p.P152fs*29(5)|p.?(5)|p.P152fs*28(4)|p.P59L(2)|p.P151_V173del23(2)|p.P152_P153del(2)|p.P152fs*27(2)|p.P20L(2)|p.D148_T155delDSTPPPGT(2)|p.T150_P153delTPPP(2)|p.Q144_G154del11(2)|p.P152_P153insXXX(2)|p.P152A(2)|p.P153fs*16(1)|p.G154fs*16(1)|p.P20R(1)|p.P59R(1)|p.T57fs*16(1)|p.P151del(1)|p.P153fs*20(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.G154fs*27(1)|p.Q144fs*16(1)|p.T18fs*16(1)|p.T150_P151delTP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGTGCCGGGCGGGGGTGTGGA	0.614		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
ZC3H4	23211	broad.mit.edu	37	19	47593291	47593305	+	In_Frame_Del	DEL	GTCCTCCTTGCCCAT	GTCCTCCTTGCCCAT	-			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:47593290_47593304AGTCCTCCTTGCCCAT>A	uc002pga.4	-	4	673_687	c.635_649ATGGGCAAGGAGGACT>T	c.(634-651)atgggcaaggaggactat>aTat	p.212_217MGKEDY>I	ZC3H4_uc002pgb.1_Non-coding_Transcript	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	Homo sapiens zinc finger CCCH-type containing 4 (ZC3H4), mRNA.	212							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		AAGTCGTCATAGTCCTCCTTGCCCATGTCCTCCTC	0.567												
NCOA3	8202	broad.mit.edu	37	20	46264741	46264742	+	In_Frame_Ins	INS	-	-	TTTATCTAC			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr20:46264740_46264741T>TTTTATCTAC	uc002xtk.3	+	11	1871_1872	c.1610_1611T>TTTTATCTAC	c.(1609-1611)ctt>cTTTTATCTAC	p.539_540insLS	NCOA3_uc002xtl.3_In_Frame_Ins_p.539_540insLS|NCOA3_uc002xtn.3_In_Frame_Ins_p.539_540insLS|NCOA3_uc010ght.2_In_Frame_Ins_p.549_550insLS|NCOA3_uc002xtm.3_In_Frame_Ins_p.539_540insLS|NCOA3_uc010zyc.2_In_Frame_Ins_p.334_335insLS	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 1, mRNA.	539	Ser-rich.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GGGACTTCCCTTTTATCTACTC	0.480												
TCF20	6942	broad.mit.edu	37	22	42610573	42610574	+	In_Frame_Ins	INS	-	-	AGG			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr22:42610572_42610573A>AAGG	uc003bcj.1	-	0	873_874	c.739_740T>CCTT	c.(739-741)ttc>CCTTc	p.F247P	TCF20_uc003bck.1_In_Frame_Ins_p.F247P	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	Homo sapiens transcription factor 20 (AR1) (TCF20), transcript variant 1, mRNA.	247	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TGGTGAAGGGAaggaggaggag	0.500												
