Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
MEGF6	1953	broad.mit.edu	37	1	3412515	3412515	+	Silent	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:3412515G>A	uc001akl.3	-	29	4037	c.3810C>T	c.(3808-3810)tgC>tgT	p.C1270C	MEGF6_uc001akk.3_Silent_p.C1035C	NM_001409	NP_001400	O75095	MEGF6_HUMAN	Homo sapiens multiple EGF-like-domains 6 (MEGF6), mRNA.	1270	EGF-like 23.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TCACAGGGTCGCAGGCCGCCC	0.706												
SZT2	23334	broad.mit.edu	37	1	43909459	43909459	+	Silent	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:43909459C>T	uc001cjk.2	+	60	8730	c.6120C>T	c.(6118-6120)ccC>ccT	p.P2040P	SZT2_uc001cjl.2_5'Flank	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	Homo sapiens seizure threshold 2 homolog (mouse) (SZT2), mRNA.	2939						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CCCCCTCACCCGCCCGCAGGT	0.572												
BARHL2	343472	broad.mit.edu	37	1	91182336	91182336	+	Silent	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:91182336C>T	uc001dns.3	-	0	459	c.417G>A	c.(415-417)acG>acA	p.T139T		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	Homo sapiens BarH-like homeobox 2 (BARHL2), mRNA.	139						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		AAAAAGAAGACGTGGAAGTCC	0.657												
SLC6A17	388662	broad.mit.edu	37	1	110735165	110735165	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:110735165G>A	uc009wfq.3	+	7	1605	c.1144G>A	c.(1144-1146)Gtc>Atc	p.V382I	SLC6A17_uc001dze.1_5'UTR	NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	Homo sapiens solute carrier family 6, member 17 (SLC6A17), mRNA.	382					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TAACACCAACGTCCTGAGCCG	0.537												
RFX5	5993	broad.mit.edu	37	1	151315095	151315095	+	Nonsense_Mutation	SNP	G	G	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:151315095G>C	uc001exv.1	-	10	1632	c.1418C>G	c.(1417-1419)tCa>tGa	p.S473*	RFX5_uc001exw.1_Nonsense_Mutation_p.S473*|RFX5_uc010pcx.1_Nonsense_Mutation_p.S433*	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	Homo sapiens regulatory factor X, 5 (influences HLA class II expression) (RFX5), transcript variant 2, mRNA.	473						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACTTCCACCTGACTTTTTTCG	0.547												
IL20	50604	broad.mit.edu	37	1	207039922	207039922	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:207039922C>T	uc001her.3	+	2	363	c.319C>T	c.(319-321)Cgg>Tgg	p.R107W	IL20_uc009xby.3_Missense_Mutation_p.R107W	NM_018724	NP_061194	Q9NYY1	IL20_HUMAN	Homo sapiens interleukin 20 (IL20), mRNA.	107			R -> Q (in dbSNP:rs35856950).		positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding			endometrium(2)|large_intestine(3)|lung(2)|pancreas(1)|urinary_tract(1)	9	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		TTATACTCTCCGGAAGATCAG	0.512												
OBSCN	84033	broad.mit.edu	37	1	228557666	228557666	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:228557666C>T	uc009xez.1	+	90	20035	c.19991C>T	c.(19990-19992)gCc>gTc	p.A6664V	OBSCN_uc001hsr.1_Missense_Mutation_p.A1293V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	6664	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCCCATTTGCCGGCGAGAGT	0.632												
ZP4	57829	broad.mit.edu	37	1	238050155	238050155	+	Missense_Mutation	SNP	C	C	T	rs148891266	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:238050155C>T	uc001hym.3	-	5	1042	c.755G>A	c.(754-756)cGa>cAa	p.R252Q	LOC100130331_uc010pyc.2_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	Homo sapiens zona pellucida glycoprotein 4 (ZP4), mRNA.	252	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATATACTGCTCGGTCTCCAGT	0.473												
OR2M1P	388762	broad.mit.edu	37	1	248285650	248285650	+	Missense_Mutation	SNP	A	A	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:248285650A>T	uc001idy.1	+	0	213	c.213A>T	c.(211-213)aaA>aaT	p.K71N						Homo sapiens olfactory receptor, family 2, subfamily M, member 1 pseudogene (OR2M1P), non-coding RNA.																		TGAGACCCAAAATTTGTAGAC	0.458												
VIM	7431	broad.mit.edu	37	10	17271903	17271903	+	Missense_Mutation	SNP	T	T	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr10:17271903T>G	uc001iou.2	+	1	895	c.482T>G	c.(481-483)gTg>gGg	p.V161G	BC078172_uc001iot.1_Non-coding_Transcript	NM_003380	NP_003371	P08670	VIME_HUMAN	Homo sapiens vimentin (VIM), mRNA.	161	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton	p.Q160K(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CGCCGGCAGGTGGACCAGCTA	0.647												
TNKS2	80351	broad.mit.edu	37	10	93579732	93579732	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr10:93579732G>A	uc001khp.3	+	5	967	c.670G>A	c.(670-672)Gta>Ata	p.V224I		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	Homo sapiens tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2), mRNA.	224					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				ATATAACAGAGTAAAGATTGT	0.328												
MKI67	4288	broad.mit.edu	37	10	129902650	129902650	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr10:129902650G>A	uc001lke.3	-	12	7649	c.7454C>T	c.(7453-7455)cCc>cTc	p.P2485L	MKI67_uc001lkf.3_Missense_Mutation_p.P2125L|MKI67_uc009yav.1_Missense_Mutation_p.P2060L|MKI67_uc009yaw.1_Missense_Mutation_p.P1635L	NM_002417	NP_002408	P46013	KI67_HUMAN	Homo sapiens antigen identified by monoclonal antibody Ki-67 (MKI67), transcript variant 1, mRNA.	2485	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTCACCAGGGGTATCTTGAG	0.473												
MUC5B	727897	broad.mit.edu	37	11	1156635	1156635	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr11:1156635C>T	uc021qbr.1	+	5	699	c.652C>T	c.(652-654)Ccc>Tcc	p.P218S				Q9HC84	MUC5B_HUMAN	Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.	214	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CAACGGGATGCCCGTGGTCAG	0.612												
BIRC3	330	broad.mit.edu	37	11	102195409	102195409	+	Missense_Mutation	SNP	T	T	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr11:102195409T>C	uc001pgx.3	+	1	2964	c.169T>C	c.(169-171)Tac>Cac	p.Y57H		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	Homo sapiens baculoviral IAP repeat containing 3 (BIRC3), transcript variant 2, mRNA.	57					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|ovary(3)|skin(1)	21	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TGGTTTCTATTACACTGGTGT	0.438			T	MALT1	MALT							
ETS1	2113	broad.mit.edu	37	11	128426243	128426243	+	Missense_Mutation	SNP	A	A	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr11:128426243A>G	uc001qej.2	-	2	242	c.157T>C	c.(157-159)Ttt>Ctt	p.F53L		NM_001143820	NP_001137292	P14921	ETS1_HUMAN	Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (ETS1), transcript variant 1, mRNA.	151	PNT.				cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.F53F(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		TCATCCCAAAAGGGGTAGCAA	0.448												
KCNA5	3741	broad.mit.edu	37	12	5153876	5153876	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:5153876C>T	uc001qni.3	+	0	792	c.563C>T	c.(562-564)cCg>cTg	p.P188L		NM_002234	NP_002225	P22460	KCNA5_HUMAN	Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5 (KCNA5), mRNA.	188				RP -> G (in Ref. 1; AAA61276).		Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.P188L(2)		NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						CTGCGGAGGCCGGTCAACGTC	0.617												
SMARCD1	6602	broad.mit.edu	37	12	50484023	50484023	+	Splice_Site	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:50484023G>A	uc001rvx.4	+	8	1044	c.874_splice	c.e8-1	p.P292_splice	SMARCD1_uc001rvy.4_Splice_Site_p.P292_splice|SMARCD1_uc009zlp.3_Splice_Site_p.P251_splice	NM_003076	NP_003067	Q96GM5	SMRD1_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (SMARCD1), transcript variant 1, mRNA.	292	Interaction with SMARCC1 and SMARCC2.|Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo.|SWIB.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			NS(1)|breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	18						GTTCCCTGCAGCCTCCCCAGT	0.458												
LACRT	90070	broad.mit.edu	37	12	55025622	55025622	+	Silent	SNP	T	T	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:55025622T>C	uc001sgi.1	-	4	292	c.254_splice	c.e4-1	p.K85_splice		NM_033277	NP_150593	Q9GZZ8	LACRT_HUMAN	Homo sapiens lacritin (LACRT), mRNA.	85					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						CCACTATGGATTCTAATTTTG	0.468												
MYF5	4617	broad.mit.edu	37	12	81111227	81111227	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:81111227C>T	uc001szg.2	+	0	520	c.385C>T	c.(385-387)Cgc>Tgc	p.R129C		NM_005593	NP_005584	P13349	MYF5_HUMAN	Homo sapiens myogenic factor 5 (MYF5), mRNA.	129	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity	p.R129S(2)|p.R129C(2)		central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						GAATGCCATCCGCTACATCGA	0.587												
TMEM132D	121256	broad.mit.edu	37	12	129558604	129558604	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:129558604G>A	uc009zyl.1	-	8	3444	c.3116C>T	c.(3115-3117)aCc>aTc	p.T1039I	TMEM132D_uc001uia.2_Missense_Mutation_p.T577I	NM_133448	NP_597705	Q14C87	T132D_HUMAN	Homo sapiens transmembrane protein 132D (TMEM132D), mRNA.	1039						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CCTTTTTGAGGTAGGGGATGT	0.488												
HECTD1	25831	broad.mit.edu	37	14	31675061	31675061	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr14:31675061G>A	uc001wrc.1	-	1	571	c.82C>T	c.(82-84)Ctt>Ttt	p.L28F	HECTD1_uc001wre.3_Non-coding_Transcript	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	Homo sapiens HECT domain containing 1 (HECTD1), mRNA.	28					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AGCTGTTCAAGGGCTATTAGT	0.428												
ARHGAP5	394	broad.mit.edu	37	14	32561946	32561946	+	Missense_Mutation	SNP	A	A	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr14:32561946A>T	uc001wrl.3	+	1	2310	c.2071A>T	c.(2071-2073)Atg>Ttg	p.M691L	ARHGAP5_uc001wrm.3_Missense_Mutation_p.M691L|ARHGAP5_uc001wrn.3_Missense_Mutation_p.M691L|ARHGAP5_uc001wro.3_Intron|ARHGAP5_uc001wrp.3_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Homo sapiens Rho GTPase activating protein 5 (ARHGAP5), transcript variant 2, mRNA.	691					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AGATAAATACATGGCTAATCT	0.358												
DICER1	23405	broad.mit.edu	37	14	95590756	95590756	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr14:95590756G>A	uc001ydw.2	-	8	1365	c.1153C>T	c.(1153-1155)Cgc>Tgc	p.R385C	DICER1_uc021sbc.1_Missense_Mutation_p.R385C|DICER1_uc001ydv.2_Missense_Mutation_p.R375C|DICER1_uc001ydx.2_Missense_Mutation_p.R385C	NM_030621	NP_803187	Q9UPY3	DICER_HUMAN	Homo sapiens dicer 1, ribonuclease type III (DICER1), transcript variant 2, mRNA.	385	Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTATATTTGCGTAAGATTTCG	0.378			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome			
GABRA5	2558	broad.mit.edu	37	15	27128491	27128491	+	Missense_Mutation	SNP	C	C	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr15:27128491C>A	uc001zbd.2	+	5	816	c.284C>A	c.(283-285)aCc>aAc	p.T95N	GABRB3_uc001zbb.3_Intron|GABRA5_uc021sgi.1_Missense_Mutation_p.T95N	NM_000810	NP_001158509	P31644	GBRA5_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 5 (GABRA5), transcript variant 1, mRNA.	95					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TAGGAGTACACCATAGACGTG	0.592												
AK302306	0	broad.mit.edu	37	15	28599954	28599954	+	Silent	SNP	A	A	G	rs144345425	by1000genomes	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr15:28599954A>G	uc010uaf.1	-	3	306	c.288T>C	c.(286-288)ctT>ctC	p.L96L	DQ595648_uc021sgj.1_5'Flank					SubName: Full=Uncharacterized protein; SubName: Full=cDNA FLJ59579, weakly similar to Homo sapiens golgi autoantigen, golgin subfamily a-like, mRNA;																		GGCTGTAGTAAAGTGCCATCT	0.478												
ALPK3	57538	broad.mit.edu	37	15	85407896	85407896	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr15:85407896G>A	uc002ble.3	+	12	5496	c.5329_splice	c.e12+1	p.G1777_splice	ALPK3_uc010upc.2_Splice_Site_p.G78_splice	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	Homo sapiens alpha-kinase 3 (ALPK3), mRNA.	1777	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGACTTGGCAGGTACGAGGGT	0.537												
SOLH	6650	broad.mit.edu	37	16	601614	601614	+	Silent	SNP	G	G	A	rs143897279	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr16:601614G>A	uc002chi.3	+	8	2658	c.2295G>A	c.(2293-2295)ccG>ccA	p.P765P	SOLH_uc002chj.3_5'Flank	NM_005632	NP_005623	O75808	CAN15_HUMAN	Homo sapiens small optic lobes homolog (Drosophila) (SOLH), mRNA.	765	Calpain catalytic.				proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Hepatocellular(780;0.00335)				AGCTCATGCCGCACGGCAGCA	0.687												
PLEKHG4	25894	broad.mit.edu	37	16	67318812	67318812	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr16:67318812C>T	uc010cef.3	+	12	2188	c.1889C>T	c.(1888-1890)gCg>gTg	p.A630V	PLEKHG4_uc002eso.4_Missense_Mutation_p.A630V|PLEKHG4_uc002esp.4_Missense_Mutation_p.A437V|PLEKHG4_uc002esq.4_Missense_Mutation_p.A630V|PLEKHG4_uc002ess.4_Missense_Mutation_p.A630V|PLEKHG4_uc010ceg.3_Missense_Mutation_p.A549V	NM_001129728	NP_056247	Q58EX7	PKHG4_HUMAN	Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 4 (PLEKHG4), transcript variant 3, mRNA.	630					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TGGGCCTGGGCGCGGTGCCAG	0.662												
ANKRD11	29123	broad.mit.edu	37	16	89341552	89341552	+	Silent	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr16:89341552C>T	uc002fmx.1	-	9	7979	c.7518G>A	c.(7516-7518)agG>agA	p.R2506R	ANKRD11_uc002fmy.1_Silent_p.R2506R	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	Homo sapiens ankyrin repeat domain 11 (ANKRD11), transcript variant 2, mRNA.	2506						nucleus		p.R2506R(2)		breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTCCTGCTGCCTGAACAGCT	0.662												
CCDC42	146849	broad.mit.edu	37	17	8638565	8638565	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr17:8638565C>T	uc002gln.3	-	5	949	c.722G>A	c.(721-723)cGc>cAc	p.R241H	CCDC42_uc002glo.3_Missense_Mutation_p.R167H	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	Homo sapiens coiled-coil domain containing 42 (CCDC42), transcript variant 1, mRNA.	241										kidney(1)|large_intestine(4)|lung(3)|ovary(1)	9						GTGCGCCCAGCGAGATTCCTG	0.562												
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr17:45219612delA	uc002ile.4	-	10	1506	c.1379delT	c.(1378-1380)ctafs	p.L460fs	CDC27_uc002ild.4_Frame_Shift_Del_p.L454fs|CDC27_uc002ilf.4_Frame_Shift_Del_p.L454fs|CDC27_uc010wkp.2_Frame_Shift_Del_p.L393fs|CDC27_uc010wkq.1_Intron	NM_001114091	NP_001107563	P30260	CDC27_HUMAN	Homo sapiens cell division cycle 27 homolog (S. cerevisiae) (CDC27), transcript variant 1, mRNA.	454				Missing (in Ref. 1; AAA60471).	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308												
CDC27	996	broad.mit.edu	37	17	45247352	45247352	+	Missense_Mutation	SNP	T	T	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr17:45247352T>C	uc002ile.4	-	3	435	c.308A>G	c.(307-309)cAt>cGt	p.H103R	CDC27_uc002ild.4_Missense_Mutation_p.H103R|CDC27_uc002ilf.4_Missense_Mutation_p.H103R|CDC27_uc010wkp.2_Missense_Mutation_p.H42R|CDC27_uc010wkq.1_Non-coding_Transcript	NM_001114091	NP_001107563	P30260	CDC27_HUMAN	Homo sapiens cell division cycle 27 homolog (S. cerevisiae) (CDC27), transcript variant 1, mRNA.	103					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding	p.S102S(1)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						AATATCATCATGGCTTTTCTG	0.308												
ESCO1	114799	broad.mit.edu	37	18	19154087	19154087	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr18:19154087C>T	uc002kth.1	-	3	1652	c.718G>A	c.(718-720)Gtg>Atg	p.V240M	ESCO1_uc002kti.1_Non-coding_Transcript	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	Homo sapiens establishment of cohesion 1 homolog 1 (S. cerevisiae) (ESCO1), mRNA.	240					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						GTTACAGGCACAGGTTTCGTT	0.418												
NETO1	81832	broad.mit.edu	37	18	70450913	70450913	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr18:70450913G>A	uc002lkw.3	-	7	1152	c.868_splice	c.e7+1	p.P290_splice	NETO1_uc002lky.2_Splice_Site_p.P290_splice	NM_001201465	NP_001188394	Q8TDF5	NETO1_HUMAN	Homo sapiens neuropilin (NRP) and tolloid (TLL)-like 1 (NETO1), transcript variant 4, mRNA.	290					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AGAATCTTACGTTCTTGAAAG	0.458												
MUC16	94025	broad.mit.edu	37	19	9088222	9088222	+	Missense_Mutation	SNP	G	G	A	rs145987902	by1000genomes	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:9088222G>A	uc002mkp.3	-	0	3797	c.3593C>T	c.(3592-3594)aCg>aTg	p.T1198M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	1198	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAAGGAAGTCGTGGAAGGTAA	0.473												
COL5A3	50509	broad.mit.edu	37	19	10088375	10088375	+	Silent	SNP	G	G	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:10088375G>T	uc002mmq.1	-	41	3107	c.3021C>A	c.(3019-3021)ggC>ggA	p.G1007G		NM_015719	NP_056534	P25940	CO5A3_HUMAN	Homo sapiens collagen, type V, alpha 3 (COL5A3), mRNA.	1007	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CACCAGGGGAGCCCTGAGAAC	0.572												
CPAMD8	27151	broad.mit.edu	37	19	17039895	17039895	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:17039895C>T	uc002nfb.3	-	23	3174	c.3142G>A	c.(3142-3144)Gtc>Atc	p.V1048I		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	Homo sapiens C3 and PZP-like, alpha-2-macroglobulin domain containing 8 (CPAMD8), mRNA.	1001						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity	p.V1048I(2)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCCCCCAGGACGATCTCGATC	0.607												
ZNF181	339318	broad.mit.edu	37	19	35232834	35232839	+	In_Frame_Del	DEL	ATATAA	ATATAA	-			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:35232834_35232839delATATAA	uc002nvu.3	+	3	2011_2016	c.1548_1553delATATAA	c.(1546-1554)ccatataaa>cca	p.YK517del	ZNF181_uc010xsb.1_In_Frame_Del_p.YK516del|ZNF181_uc010xsc.1_In_Frame_Del_p.YK452del	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	Homo sapiens zinc finger protein 181 (ZNF181), transcript variant 1, mRNA.	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(1)	22	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GAGAAAAGCCATATAAATGTAATGAG	0.388												
UPK1A	11045	broad.mit.edu	37	19	36159540	36159540	+	Missense_Mutation	SNP	G	G	A	rs111275297		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:36159540G>A	uc010eeh.3	+	1	269	c.269G>A	c.(268-270)cGg>cAg	p.R90Q	UPK1A_uc002oaw.3_Missense_Mutation_p.R90Q|BC007817_uc002oax.1_Missense_Mutation_p.R3W			O00322	UPK1A_HUMAN	Homo sapiens uroplakin 1A (UPK1A), mRNA.	90					epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity			breast(1)|large_intestine(4)|lung(2)|stomach(2)	9	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGCCGCCGCCGGTCCATGGTC	0.592												
GPR77	27202	broad.mit.edu	37	19	47844750	47844750	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:47844750C>T	uc002pgk.1	+	1	765	c.694C>T	c.(694-696)Cgg>Tgg	p.R232W	GPR77_uc010ela.1_Missense_Mutation_p.R232W|GPR77_uc021uwn.1_Missense_Mutation_p.R232W	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	Homo sapiens G protein-coupled receptor 77 (GPR77), mRNA.	232					chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity	p.R232R(1)		NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		CCGACGCTGCCGGCCGCTGGG	0.672												
ELSPBP1	64100	broad.mit.edu	37	19	48519291	48519291	+	Missense_Mutation	SNP	C	C	T	rs145971035		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:48519291C>T	uc002pht.3	+	3	528	c.350C>T	c.(349-351)aCg>aTg	p.T117M		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	Homo sapiens epididymal sperm binding protein 1 (ELSPBP1), mRNA.	117	Fibronectin type-II 2.				single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		TTCTGTGAAACGAATGGTGAG	0.552												
DKKL1	27120	broad.mit.edu	37	19	49867863	49867863	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:49867863G>A	uc002pnk.3	+	1	249	c.35G>A	c.(34-36)cGg>cAg	p.R12Q	TEAD2_uc002pni.3_5'Flank|TEAD2_uc002pnj.3_5'Flank|TEAD2_uc010yao.2_5'Flank|TEAD2_uc010emw.3_5'Flank|DKKL1_uc021uxk.1_5'UTR|DKKL1_uc021uxl.1_Missense_Mutation_p.R12Q	NM_014419	NP_001184231	Q9UK85	DKKL1_HUMAN	Homo sapiens dickkopf-like 1 (DKKL1), transcript variant 1, mRNA.	12					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity			large_intestine(2)|upper_aerodigestive_tract(1)	3		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CCCGCAAGGCGGCATCTGCTG	0.672												
C19orf75	284369	broad.mit.edu	37	19	51768774	51768774	+	Missense_Mutation	SNP	T	T	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:51768774T>A	uc002pwb.1	+	2	556	c.175T>A	c.(175-177)Tcc>Acc	p.S59T	C19orf75_uc010eov.1_Intron|C19orf75_uc010ycw.1_Intron	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	Homo sapiens chromosome 19 open reading frame 75 (C19orf75), mRNA.	59						integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)	18						CCAAGTGACTTCCACCATGCT	0.567												
KCNH7	90134	broad.mit.edu	37	2	163253351	163253351	+	Nonsense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:163253351G>A	uc002uch.2	-	10	2741	c.2512C>T	c.(2512-2514)Cga>Tga	p.R838*		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 7 (KCNH7), transcript variant 1, mRNA.	838					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AAGTCTTCTCGCTGAATCTTA	0.383												
TTC21B	79809	broad.mit.edu	37	2	166799848	166799848	+	Missense_Mutation	SNP	G	G	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:166799848G>T	uc002udk.3	-	4	566	c.433C>A	c.(433-435)Cac>Aac	p.H145N	TTC21B_uc002udl.3_Missense_Mutation_p.H145N|LOC100506134_uc021vsa.1_Intron|LOC100506134_uc002udm.2_Intron	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	Homo sapiens tetratricopeptide repeat domain 21B (TTC21B), mRNA.	145						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						TTCAAAACGTGTCCCTGTAAA	0.313												
SDPR	8436	broad.mit.edu	37	2	192700730	192700730	+	Silent	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:192700730G>A	uc002utb.3	-	1	1552	c.1197C>T	c.(1195-1197)taC>taT	p.Y399Y		NM_004657	NP_004648	O95810	SDPR_HUMAN	Homo sapiens serum deprivation response (SDPR), mRNA.	399						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	ATGTTAGCGCGTAGCTACCCT	0.612												
NYAP2	57624	broad.mit.edu	37	2	226447389	226447389	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:226447389C>T	uc002voe.2	+	3	1431	c.1256C>T	c.(1255-1257)aCg>aTg	p.T419M	NYAP2_uc010fxa.1_Intron|NYAP2_uc002vof.1_Missense_Mutation_p.T189M	NM_020864	NP_065915	Q9P242	K1486_HUMAN	Homo sapiens neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 (NYAP2), mRNA.	419	Pro-rich.																CCCCCGTCTACGCTGTACCGA	0.662												
SIGLEC1	6614	broad.mit.edu	37	20	3674185	3674185	+	Silent	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:3674185G>A	uc002wja.3	-	12	3417	c.3417C>T	c.(3415-3417)gtC>gtT	p.V1139V	SIGLEC1_uc002wiz.4_Silent_p.V1139V|SIGLEC1_uc002wjb.1_5'Flank	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	Homo sapiens sialic acid binding Ig-like lectin 1, sialoadhesin (SIGLEC1), mRNA.	1139	Ig-like C2-type 11.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CCCTGACTGTGACGTTGGGCA	0.657												
SRC	6714	broad.mit.edu	37	20	36026230	36026230	+	Missense_Mutation	SNP	C	C	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:36026230C>G	uc002xgx.3	+	8	1281	c.832C>G	c.(832-834)Cag>Gag	p.Q278E	SRC_uc002xgy.3_Missense_Mutation_p.Q278E	NM_005417	NP_938033	P12931	SRC_HUMAN	Homo sapiens v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1, mRNA.	278	Protein kinase.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(16)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CAAGCTGGGCCAGGGCTGCTT	0.697												
PTPRT	11122	broad.mit.edu	37	20	40713368	40713368	+	Missense_Mutation	SNP	G	G	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:40713368G>T	uc002xkg.3	-	28	4274	c.4090C>A	c.(4090-4092)Cag>Aag	p.Q1364K	PTPRT_uc010ggj.3_Missense_Mutation_p.Q1383K|PTPRT_uc010ggi.3_Missense_Mutation_p.Q567K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, T (PTPRT), transcript variant 2, mRNA.	1364	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.A1364A(1)		NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TACTGCTCCTGCCACTTCTCC	0.597												
DIDO1	11083	broad.mit.edu	37	20	61511189	61511189	+	Missense_Mutation	SNP	C	C	T	rs143474883		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:61511189C>T	uc002ydr.2	-	15	6431	c.6119G>A	c.(6118-6120)cGc>cAc	p.R2040H	DIDO1_uc002yds.2_Missense_Mutation_p.R2040H	NM_001193369	NP_149072	Q9BTC0	DIDO1_HUMAN	Homo sapiens death inducer-obliterator 1 (DIDO1), transcript variant 5, mRNA.	2040					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CTCCTCCCAGCGGTCCTTCCG	0.741												
KRTAP10-12	386685	broad.mit.edu	37	21	46117103	46117103	+	Translation_Start_Site	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr21:46117103C>T	uc002zfw.1	+	0					TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198699	NP_941972	P60413	KR10C_HUMAN	Homo sapiens keratin associated protein 10-12 (KRTAP10-12), mRNA.							keratin filament				large_intestine(1)|lung(8)	9						ACCCCCAGCACGGCTGCATCC	0.627												
PRAME	23532	broad.mit.edu	37	22	22891015	22891015	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:22891015G>A	uc002zwf.3	-	4	1160	c.1004C>T	c.(1003-1005)tCg>tTg	p.S335L	abParts_uc021wml.1_Intron|abParts_uc021wmm.1_Intron|PRAME_uc011air.2_Missense_Mutation_p.S319L|PRAME_uc010gtr.3_Missense_Mutation_p.S335L|PRAME_uc002zwg.3_Missense_Mutation_p.S335L|PRAME_uc002zwh.3_Missense_Mutation_p.S335L|PRAME_uc002zwi.3_Missense_Mutation_p.S335L|PRAME_uc002zwj.3_Missense_Mutation_p.S335L|PRAME_uc002zwk.3_Missense_Mutation_p.S335L	NM_206956	NP_996839	P78395	PRAME_HUMAN	Homo sapiens preferentially expressed antigen in melanoma (PRAME), transcript variant 5, mRNA.	335					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		ATCCCCTTCCGAAAGCCGGCA	0.542												
ELFN2	114794	broad.mit.edu	37	22	37769438	37769438	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:37769438G>A	uc003asq.4	-	2	2923	c.2137C>T	c.(2137-2139)Ccc>Tcc	p.P713S	ELFN2_uc021wph.1_Missense_Mutation_p.P713S	NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	Homo sapiens extracellular leucine-rich repeat and fibronectin type III domain containing 2 (ELFN2), mRNA.	713						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					TACAGGGCGGGAAAGCTGTGC	0.711												
ENTHD1	150350	broad.mit.edu	37	22	40283672	40283672	+	Silent	SNP	G	G	A	rs146928757		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:40283672G>A	uc003ayg.3	-	1	332	c.81C>T	c.(79-81)aaC>aaT	p.N27N		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	Homo sapiens ENTH domain containing 1 (ENTHD1), mRNA.	27	ENTH.							p.N27N(2)		breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					CCCAAGGGTCGTTAGAAGTTG	0.398												
CYP2D6	1565	broad.mit.edu	37	22	42523567	42523567	+	Missense_Mutation	SNP	T	T	C	rs61736517		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:42523567T>C	uc003bce.3	-	6	1145	c.1055A>G	c.(1054-1056)cAc>cGc	p.H352R	LOC100132273_uc003bcd.1_Intron|CYP2D6_uc010gyu.3_Missense_Mutation_p.H46R|CYP2D6_uc003bcf.3_Missense_Mutation_p.H301R	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1, mRNA.	352							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	p.L352L(1)		NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTAGGGCATGTGAGCCTGGTC	0.592												
ARSA	410	broad.mit.edu	37	22	51063597	51063597	+	Silent	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:51063597G>A	uc003bna.4	-	7	1510	c.1248C>T	c.(1246-1248)tgC>tgT	p.C416C	ARSA_uc021wsd.1_Silent_p.C502C|ARSA_uc021wse.1_Silent_p.C502C|ARSA_uc021wsf.1_Silent_p.C502C|ARSA_uc003bmz.4_Silent_p.C500C	NM_001085428	NP_001078897	P15289	ARSA_HUMAN	Homo sapiens arylsulfatase A (ARSA), transcript variant 5, mRNA.	500						lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|skin(1)	9		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	CTGGGCAATGGCAGCAAGCTG	0.701												
DNAH12	201625	broad.mit.edu	37	3	57488121	57488121	+	Missense_Mutation	SNP	C	C	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:57488121C>A	uc003dit.2	-	9	1353	c.1172G>T	c.(1171-1173)tGg>tTg	p.W391L	DNAH12_uc003diu.2_Missense_Mutation_p.W391L	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	Homo sapiens dynein, axonemal, heavy chain 12 (DNAH12), transcript variant 1, mRNA.	391	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						ATCAACAGCCCAGTGTAACAC	0.393												
SLC9C1	285335	broad.mit.edu	37	3	111901019	111901019	+	Silent	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:111901019C>T	uc003dyu.3	-	20	2832	c.2610G>A	c.(2608-2610)ccG>ccA	p.P870P	SLC9C1_uc011bhu.2_Silent_p.P133P|SLC9C1_uc010hqc.3_Silent_p.P822P	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	Homo sapiens solute carrier family 9, member 10 (SLC9A10), mRNA.	870					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TATCTAGCCACGGAATATGAT	0.259												
UBA5	79876	broad.mit.edu	37	3	132390695	132390695	+	Silent	SNP	T	T	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:132390695T>C	uc003epa.4	+	6	896	c.654T>C	c.(652-654)ctT>ctC	p.L218L	NPHP3_uc003eoz.1_Intron|UBA5_uc010htr.3_Silent_p.L162L|UBA5_uc003epb.4_Silent_p.L162L	NM_024818	NP_938143	Q9GZZ9	UBA5_HUMAN	Homo sapiens ubiquitin-like modifier activating enzyme 5 (UBA5), transcript variant 1, mRNA.	218					protein ufmylation	aggresome|cytoplasm|nucleus	ATP binding|cofactor binding|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding|UFM1 activating enzyme activity			breast(2)|endometrium(4)|kidney(4)|large_intestine(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						ATATACAGCTTATAATTCCTG	0.368												
PRR23B	389151	broad.mit.edu	37	3	138739151	138739151	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:138739151G>A	uc003esy.1	-	0	618	c.353C>T	c.(352-354)tCg>tTg	p.S118L		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	Homo sapiens proline rich 23B (PRR23B), mRNA.	118										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCCGGCAGACGAGTCGTGCTG	0.632												
B3GALNT1	8706	broad.mit.edu	37	3	160803715	160803715	+	Missense_Mutation	SNP	T	T	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:160803715T>A	uc003fdv.3	-	4	1247	c.828A>T	c.(826-828)ttA>ttT	p.L276F	B3GALNT1_uc003fdw.3_Missense_Mutation_p.L276F|B3GALNT1_uc003fdx.3_Missense_Mutation_p.L276F|B3GALNT1_uc003fdy.3_Missense_Mutation_p.L276F|B3GALNT1_uc003fdz.3_Missense_Mutation_p.L276F|B3GALNT1_uc003fea.3_Missense_Mutation_p.L276F|B3GALNT1_uc011bpa.2_Intron|B3GALNT1_uc021xgw.1_Missense_Mutation_p.L276F	NM_033169	NP_149359	O75752	B3GL1_HUMAN	Homo sapiens beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) (B3GALNT1), transcript variant 4, mRNA.	276					protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			TCACTTTTAATAAATTCAAAC	0.363												
MUC4	4585	broad.mit.edu	37	3	195509188	195509188	+	Missense_Mutation	SNP	G	G	A	rs71291868		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:195509188G>A	uc021xjp.1	-	1	9419	c.9263C>T	c.(9262-9264)cCt>cTt	p.P3088L	MUC4_uc021xjm.1_5'Flank|MUC4_uc021xjn.1_5'Flank|MUC4_uc021xjo.1_5'Flank|MUC4_uc021xjg.1_5'Flank|MUC4_uc021xjh.1_5'Flank|MUC4_uc021xji.1_5'Flank|MUC4_uc021xjj.1_5'Flank|MUC4_uc021xjk.1_5'Flank|MUC4_uc021xjl.1_5'Flank|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	829					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACAGGAAGAGGGGTGGCGTG	0.592												
NCBP2	22916	broad.mit.edu	37	3	196664454	196664454	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:196664454C>T	uc003fxd.1	-	2	416	c.326G>A	c.(325-327)cGa>cAa	p.R109Q	NCBP2_uc003fxb.1_Missense_Mutation_p.R39Q|NCBP2_uc011btz.1_Missense_Mutation_p.R91Q|NCBP2_uc003fxc.1_Non-coding_Transcript|NCBP2_uc003fxe.1_Missense_Mutation_p.R56Q|NCBP2_uc003fxf.3_3'UTR	NM_007362	NP_031388	P52298	NCBP2_HUMAN	Homo sapiens nuclear cap binding protein subunit 2, 20kDa (NCBP2), transcript variant 1, mRNA.	109	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		GCGAATGATTCGGTCATCCAG	0.527												
CSN2	1447	broad.mit.edu	37	4	70822070	70822070	+	Nonstop_Mutation	SNP	A	A	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:70822070A>G	uc003hes.4	-	5	692	c.679T>C	c.(679-681)Taa>Caa	p.*227Q	CSN2_uc003het.4_Nonstop_Mutation_p.*226Q	NM_001891	NP_001882	P05814	CASB_HUMAN	Homo sapiens casein beta (CSN2), mRNA.	0					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						AAATCTTCTTAGACCTTAAAA	0.269												
ALB	213	broad.mit.edu	37	4	74279142	74279142	+	Missense_Mutation	SNP	C	C	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:74279142C>G	uc003hgs.4	+	7	922	c.849C>G	c.(847-849)gaC>gaG	p.D283E	ALB_uc011cbe.2_5'UTR|ALB_uc003hgw.4_Missense_Mutation_p.D91E|ALB_uc011cbf.2_Missense_Mutation_p.D173E	NM_000477	NP_000468	P02768	ALBU_HUMAN	Homo sapiens albumin (ALB), mRNA.	283	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TATAGGCGGACCTTGCCAAGT	0.393												
AFM	173	broad.mit.edu	37	4	74354363	74354363	+	Missense_Mutation	SNP	A	A	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:74354363A>G	uc003hhb.3	+	6	761	c.730A>G	c.(730-732)Agt>Ggt	p.S244G		NM_001133	NP_001124	P43652	AFAM_HUMAN	Homo sapiens afamin (AFM), mRNA.	244	Albumin 2.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCGATACTCAGTCAAAAATT	0.343												
MMRN1	22915	broad.mit.edu	37	4	90874191	90874191	+	Missense_Mutation	SNP	T	T	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:90874191T>G	uc003hst.3	+	7	3380	c.3309T>G	c.(3307-3309)ttT>ttG	p.F1103L	MMRN1_uc010iku.3_Missense_Mutation_p.F406L|MMRN1_uc011cds.2_Missense_Mutation_p.F845L	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	Homo sapiens multimerin 1 (MMRN1), mRNA.	1103	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGGTGGCATTTTTTGCATCTC	0.338												
KLKB1	3818	broad.mit.edu	37	4	187157968	187157968	+	Missense_Mutation	SNP	T	T	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:187157968T>A	uc003iyy.3	+	4	433	c.362T>A	c.(361-363)aTg>aAg	p.M121K	KLKB1_uc011clc.2_5'UTR|KLKB1_uc011cld.2_Missense_Mutation_p.M83K	NM_000892	NP_000883	P03952	KLKB1_HUMAN	Homo sapiens kallikrein B, plasma (Fletcher factor) 1 (KLKB1), mRNA.	121	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GGAGTTGATATGAGAGGAGTC	0.378												
CYSTM1	84418	broad.mit.edu	37	5	139622928	139622928	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr5:139622928C>T	uc003lfd.3	+	2	464	c.226C>T	c.(226-228)Cca>Tca	p.P76S	CYSTM1_uc010jfi.3_Non-coding_Transcript	NM_032412	NP_115788	Q9H1C7	CE032_HUMAN	Homo sapiens chromosome 5 open reading frame 32 (C5orf32), mRNA.	76																	TGAGCTAGGACCATCCACCTG	0.582												
SH3TC2	79628	broad.mit.edu	37	5	148417964	148417964	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr5:148417964C>T	uc003lpu.3	-	7	1047	c.895G>A	c.(895-897)Ggc>Agc	p.G299S	SH3TC2_uc003lpp.1_Non-coding_Transcript|SH3TC2_uc003lps.3_Non-coding_Transcript|SH3TC2_uc003lpt.3_5'UTR|SH3TC2_uc010jgx.3_Missense_Mutation_p.G292S|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_Missense_Mutation_p.G184S	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	Homo sapiens SH3 domain and tetratricopeptide repeats 2 (SH3TC2), mRNA.	299	SH3.						binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAAAGCCGATGATCTCA	0.473												
OR2J3	442186	broad.mit.edu	37	6	29080039	29080039	+	Silent	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr6:29080039C>T	uc011dll.2	+	0	372	c.372C>T	c.(370-372)gaC>gaT	p.D124D		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily J, member 3 (OR2J3), mRNA.	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						TGTCCTATGACCGTTATGCAG	0.488												
TNXB	7148	broad.mit.edu	37	6	32041532	32041532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr6:32041532G>A	uc003nzl.2	-	11	4775	c.4573C>T	c.(4573-4575)Cga>Tga	p.R1525*		NM_019105	NP_061978	P22105	TENX_HUMAN	Homo sapiens tenascin XB (TNXB), transcript variant XB, mRNA.	1612	Fibronectin type-III 7.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GTGACCTCTCGCTGGTCTGCC	0.567												
C6orf89	221477	broad.mit.edu	37	6	36891125	36891125	+	Missense_Mutation	SNP	T	T	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr6:36891125T>A	uc003omw.3	+	7	1136	c.973T>A	c.(973-975)Tat>Aat	p.Y325N	C6orf89_uc003omv.3_Missense_Mutation_p.Y212N|C6orf89_uc003omx.3_Missense_Mutation_p.Y318N|C6orf89_uc011dtr.2_Missense_Mutation_p.Y212N	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	Homo sapiens chromosome 6 open reading frame 89 (C6orf89), mRNA.	318						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						CCCTCAAGGCTATGTCGACAC	0.552												
AOAH	313	broad.mit.edu	37	7	36616236	36616236	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:36616236C>T	uc022abu.1	-	12	1366	c.965G>A	c.(964-966)cGc>cAc	p.R322H	AOAH_uc003tfh.4_Missense_Mutation_p.R322H|AOAH_uc011kba.2_Missense_Mutation_p.R290H	NM_001177506	NP_001170977	P28039	AOAH_HUMAN	Homo sapiens acyloxyacyl hydrolase (neutrophil) (AOAH), transcript variant 2, mRNA.	322					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity	p.R322C(1)		NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						TTTCCATAAGCGAAGGTAAAT	0.303												
HECW1	23072	broad.mit.edu	37	7	43484236	43484236	+	Nonsense_Mutation	SNP	G	G	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:43484236G>T	uc003tid.1	+	10	2070	c.1465G>T	c.(1465-1467)Gag>Tag	p.E489*	HECW1_uc011kbi.1_Nonsense_Mutation_p.E489*	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	Homo sapiens HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), mRNA.	489	Glu-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GCCCTTGGAGGAGGAAGCAAC	0.632												
DDC	1644	broad.mit.edu	37	7	50534977	50534977	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:50534977G>A	uc003tpg.4	-	12	1378	c.1177C>T	c.(1177-1179)Cgc>Tgc	p.R393C	DDC_uc022ade.1_Missense_Mutation_p.R315C|DDC_uc003tpf.4_Missense_Mutation_p.R393C|DDC_uc022adb.1_Missense_Mutation_p.R355C|DDC_uc022adc.1_Missense_Mutation_p.R345C|DDC_uc022add.1_Missense_Mutation_p.R300C	NM_001082971	NP_001076440	P20711	DDC_HUMAN	Homo sapiens dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), transcript variant 1, mRNA.	393					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	GGATCCTGGCGCACCAGTGAC	0.433												
DDC	1644	broad.mit.edu	37	7	50607722	50607722	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:50607722G>A	uc003tpg.4	-	2	407	c.206C>T	c.(205-207)aCg>aTg	p.T69M	DDC_uc022ade.1_Intron|DDC_uc003tpf.4_Missense_Mutation_p.T69M|DDC_uc022adb.1_Intron|DDC_uc022adc.1_Missense_Mutation_p.T69M|DDC_uc022add.1_Missense_Mutation_p.T69M|DDC_uc022adf.1_Missense_Mutation_p.T69M|LOC100129427_uc022adg.1_Non-coding_Transcript	NM_001082971	NP_001076440	P20711	DDC_HUMAN	Homo sapiens dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), transcript variant 1, mRNA.	69	2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding	p.T69M(2)		breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	GTGCCAGTGCGTCACCTGCAT	0.647												
SEMA3D	223117	broad.mit.edu	37	7	84727157	84727157	+	Silent	SNP	T	T	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:84727157T>C	uc003uic.3	-	1	316	c.276A>G	c.(274-276)ctA>ctG	p.L92L	SEMA3D_uc010led.3_Silent_p.L92L|SEMA3D_uc010lee.1_Silent_p.L92L	NM_152754	NP_689967	O95025	SEM3D_HUMAN	Homo sapiens sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (SEMA3D), mRNA.	92	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						CCAGACTGAGTAGAAAGATGT	0.363												
ADAM22	53616	broad.mit.edu	37	7	87774461	87774461	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:87774461G>A	uc003ujn.3	+	15	1557	c.1342G>A	c.(1342-1344)Ggc>Agc	p.G448S	ADAM22_uc003ujk.2_Missense_Mutation_p.G448S|ADAM22_uc003ujl.2_Missense_Mutation_p.G448S|ADAM22_uc003ujm.3_Missense_Mutation_p.G448S|ADAM22_uc003ujo.3_Missense_Mutation_p.G448S|ADAM22_uc003ujp.1_Missense_Mutation_p.G500S	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	Homo sapiens ADAM metallopeptidase domain 22 (ADAM22), transcript variant 1, mRNA.	448	Disintegrin.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TCCTGAGTGTGGCAATGGCTT	0.408												
ZC3HAV1	56829	broad.mit.edu	37	7	138764823	138764823	+	Silent	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:138764823C>T	uc003vun.3	-	3	1252	c.864G>A	c.(862-864)gcG>gcA	p.A288A	ZC3HAV1_uc003vuo.3_5'Flank|ZC3HAV1_uc003vup.3_Silent_p.A288A	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	Homo sapiens zinc finger CCCH-type, antiviral 1 (ZC3HAV1), transcript variant 1, mRNA.	288					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						CGTCCACAGGCGCGTCCTCCA	0.587												
MKRN1	23608	broad.mit.edu	37	7	140154505	140154505	+	Nonsense_Mutation	SNP	C	C	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:140154505C>A	uc003vvt.2	-	7	1486	c.1261G>T	c.(1261-1263)Gaa>Taa	p.E421*	MKRN1_uc003vvs.2_Nonsense_Mutation_p.E357*|MKRN1_uc011krd.1_Nonsense_Mutation_p.E155*	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	Homo sapiens makorin ring finger protein 1 (MKRN1), transcript variant 1, mRNA.	421							ligase activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	16	Melanoma(164;0.00956)					TCAATGAGTTCCCAGAAGTGG	0.468												
PIWIL2	55124	broad.mit.edu	37	8	22165552	22165552	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr8:22165552G>A	uc003xbn.2	+	13	1800	c.1652G>A	c.(1651-1653)cGt>cAt	p.R551H	PIWIL2_uc011kzf.1_Missense_Mutation_p.R551H|PIWIL2_uc010ltv.2_Missense_Mutation_p.R551H	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	Homo sapiens piwi-like 2 (Drosophila) (PIWIL2), transcript variant 2, mRNA.	551					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		GAACTGATGCGTTGGGGGCTC	0.453												
ADAM28	10863	broad.mit.edu	37	8	24181517	24181517	+	Splice_Site	SNP	G	G	A	rs138768775		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr8:24181517G>A	uc003xdy.3	+	9	973	c.890_splice	c.e9+1	p.T297_splice	ADAM28_uc003xdx.3_Splice_Site_p.T297_splice|ADAM28_uc011kzz.2_Splice_Site_p.T64_splice|ADAM28_uc011laa.2_Splice_Site|ADAM28_uc010lua.3_5'Flank	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	Homo sapiens ADAM metallopeptidase domain 28 (ADAM28), transcript variant 1, mRNA.	297	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AGTTAATCACGTATGTACAGA	0.423												
PTGR1	22949	broad.mit.edu	37	9	114332377	114332377	+	Silent	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr9:114332377G>A	uc010mue.3	-	8	1136	c.873C>T	c.(871-873)gtC>gtT	p.V291V	ZNF483_uc004bfg.2_Intron|PTGR1_uc011lwr.2_Silent_p.V291V|PTGR1_uc004bfh.2_Silent_p.V291V|PTGR1_uc004bfi.3_Silent_p.V291V|PTGR1_uc004bfj.3_Silent_p.V168V	NM_001146109	NP_001139581	Q14914	PTGR1_HUMAN	Homo sapiens prostaglandin reductase 1 (PTGR1), transcript variant 3, mRNA.	291					leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)	11						TTACCTCTAAGACCCATTTCA	0.498												
TPRN	286262	broad.mit.edu	37	9	140086667	140086667	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr9:140086667C>T	uc004clt.3	-	2	2117	c.2117G>A	c.(2116-2118)cGg>cAg	p.R706Q	TPRN_uc004clu.3_Intron	NM_001128228	NP_001121700	Q4KMQ1	TPRN_HUMAN	Homo sapiens taperin (TPRN), mRNA.	691					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						TGGGCTCGCCCGGGTGTCAGA	0.662												
CACNA1B	774	broad.mit.edu	37	9	141012527	141012527	+	Silent	SNP	A	A	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr9:141012527A>T	uc004cog.3	+	41	6046	c.5901A>T	c.(5899-5901)ggA>ggT	p.G1967G	CACNA1B_uc022bqn.1_Silent_p.G1967G|CACNA1B_uc004coi.3_Silent_p.G1181G	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	Homo sapiens calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B), transcript variant 1, mRNA.	1969					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGCGGTCAGGAGCACTGGTGA	0.642												
IL3RA	3563	broad.mit.edu	37	X	1471117	1471117	+	Silent	SNP	C	C	T	rs142385163	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:1471117C>T	uc004cps.3	+	4	772	c.423C>T	c.(421-423)aaC>aaT	p.N141N	CRLF2_uc022brt.1_Intron|IL3RA_uc011mhd.2_Silent_p.N63N	NM_002183	NP_002174	P26951	IL3RA_HUMAN	Homo sapiens interleukin 3 receptor, alpha (low affinity) (IL3RA), mRNA.	141						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGTACTTGAACGTTGCCAAGT	0.647												
ARSE	415	broad.mit.edu	37	X	2867414	2867414	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:2867414G>A	uc011mhh.2	-	6	1321	c.860C>T	c.(859-861)aCg>aTg	p.T287M	ARSE_uc011mhi.2_Missense_Mutation_p.T208M|ARSE_uc004crc.4_Missense_Mutation_p.T262M			P51690	ARSE_HUMAN	Homo sapiens arylsulfatase E (chondrodysplasia punctata 1) (ARSE), mRNA.	262					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGGCTGCTCCGTGATGGTGTG	0.532												
GPR143	4935	broad.mit.edu	37	X	9693807	9693807	+	Silent	SNP	G	G	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:9693807G>C	uc004cst.2	-	8	1342	c.1194C>G	c.(1192-1194)ctC>ctG	p.L398L		NM_000273	NP_000264	P51810	GP143_HUMAN	Homo sapiens G protein-coupled receptor 143 (GPR143), mRNA.	398					calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Hepatocellular(5;0.000888)				CATGGGTTGGGAGAGCAGGGT	0.473												
FRMPD4	9758	broad.mit.edu	37	X	12735884	12735884	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:12735884C>T	uc004cuz.2	+	15	3445	c.2939C>T	c.(2938-2940)cCg>cTg	p.P980L	FRMPD4_uc011mij.2_Missense_Mutation_p.P972L	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	Homo sapiens FERM and PDZ domain containing 4 (FRMPD4), mRNA.	980					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						ACCGACCTCCCGCCCAAAGTT	0.572												
FTSJ1	24140	broad.mit.edu	37	X	48337447	48337447	+	Missense_Mutation	SNP	A	A	T	rs75296308	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:48337447A>T	uc004djo.1	+	4	627	c.304A>T	c.(304-306)Atc>Ttc	p.I102F	FTSJ1_uc004djn.1_Missense_Mutation_p.I102F|FTSJ1_uc011mlw.1_5'UTR	NM_012280	NP_036412	Q9UET6	RRMJ1_HUMAN	Homo sapiens FtsJ homolog 1 (E. coli) (FTSJ1), transcript variant 1, mRNA.	102					RNA methylation|rRNA processing		methyltransferase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|lung(4)|skin(1)	7						CAAGGAGATCATCCAGCACTT	0.632												
PORCN	64840	broad.mit.edu	37	X	48374470	48374470	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:48374470G>A	uc010nie.1	+	12	1267	c.1109G>A	c.(1108-1110)cGg>cAg	p.R370Q	PORCN_uc004djr.1_Missense_Mutation_p.R365Q|PORCN_uc004djs.1_Missense_Mutation_p.R359Q|PORCN_uc011mlx.1_Missense_Mutation_p.R288Q|PORCN_uc004dju.1_Missense_Mutation_p.R228Q|PORCN_uc004djv.1_Missense_Mutation_p.R370Q|PORCN_uc004djw.1_Missense_Mutation_p.R364Q	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	Homo sapiens porcupine homolog (Drosophila) (PORCN), transcript variant D, mRNA.	370					Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CGCCTGGCTCGGATCCTCAGT	0.627												
TSR2	90121	broad.mit.edu	37	X	54467162	54467162	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:54467162G>A	uc004dte.3	+	1	123	c.121G>A	c.(121-123)Gag>Aag	p.E41K	TSR2_uc004dtf.3_Intron	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	Homo sapiens TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) (TSR2), mRNA.	41					rRNA processing		protein binding			breast(1)|endometrium(3)|lung(2)	6						GCACAGCCAGGAGAAGGCCAA	0.607												
ZC3H12B	340554	broad.mit.edu	37	X	64721735	64721735	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:64721735G>A	uc010nko.3	+	4	1224	c.1157G>A	c.(1156-1158)cGt>cAt	p.R386H		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	Homo sapiens zinc finger CCCH-type containing 12B (ZC3H12B), mRNA.	375							endonuclease activity|nucleic acid binding|zinc ion binding	p.R236H(1)|p.R322H(1)		breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAACCCCAGCGTTCGGTGGCT	0.532												
SLC7A3	84889	broad.mit.edu	37	X	70147393	70147393	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:70147393C>T	uc004dyn.3	-	6	1298	c.1124G>A	c.(1123-1125)cGg>cAg	p.R375Q	SLC7A3_uc004dyo.3_Missense_Mutation_p.R375Q	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 (SLC7A3), transcript variant 1, mRNA.	375					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GGTGTGGATCCGAGCAAGTAC	0.577												
RAB40A	142684	broad.mit.edu	37	X	102755508	102755508	+	Silent	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:102755508G>A	uc022cbs.1	-	0	177	c.177C>T	c.(175-177)gaC>gaT	p.D59D	RAB40A_uc004ekk.3_Silent_p.D59D	NM_080879	NP_543155	Q8WXH6	RB40A_HUMAN	Homo sapiens RAB40A, member RAS oncogene family (RAB40A), mRNA.	59					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	12						CCCGCTGGCCGTCCAGCAGGA	0.587												
NRK	203447	broad.mit.edu	37	X	105179166	105179166	+	Silent	SNP	C	C	T	rs56273831		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:105179166C>T	uc004emd.3	+	20	3807	c.3504C>T	c.(3502-3504)taC>taT	p.Y1168Y	NRK_uc010npc.1_Silent_p.Y836Y	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Homo sapiens Nik related kinase (NRK), mRNA.	1168							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.Y1168C(1)		breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TTGCAGTATACGCTGGATTCG	0.383										HNSCC(51;0.14)		
RNF128	79589	broad.mit.edu	37	X	105970562	105970562	+	Missense_Mutation	SNP	C	C	T			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:105970562C>T	uc004eml.3	+	0	669	c.419C>T	c.(418-420)gCg>gTg	p.A140V	RNF128_uc004emk.3_Intron	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	Homo sapiens ring finger protein 128 (RNF128), transcript variant 1, mRNA.	140	PA.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)	11						GAGAGAGGGGCGTCTGGAGCC	0.597												
DOCK11	139818	broad.mit.edu	37	X	117748686	117748686	+	Missense_Mutation	SNP	T	T	C			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:117748686T>C	uc004eqp.2	+	28	3191	c.3128T>C	c.(3127-3129)aTt>aCt	p.I1043T	DOCK11_uc004eqq.2_Missense_Mutation_p.I809T	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	Homo sapiens dedicator of cytokinesis 11 (DOCK11), mRNA.	1043					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AGAGGATTTATTTTCAATTTA	0.299												
USP26	83844	broad.mit.edu	37	X	132161937	132161937	+	Silent	SNP	G	G	A	rs142413133	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:132161937G>A	uc011mvf.2	-	0	364	c.312C>T	c.(310-312)aaC>aaT	p.N104N	USP26_uc010nrm.1_Silent_p.N104N	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	Homo sapiens ubiquitin specific peptidase 26 (USP26), mRNA.	104					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					GCTGAACCTCGTTTTGATGAA	0.383												
ZNF75D	7626	broad.mit.edu	37	X	134426220	134426220	+	Silent	SNP	A	A	G			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:134426220A>G	uc022ceq.1	-	2	981	c.591T>C	c.(589-591)ccT>ccC	p.P197P	DKFZp451F083_uc004eym.3_Intron|DKFZp451F083_uc022cep.1_Intron|ZNF75D_uc004eyo.3_Intron	NM_007131	NP_009062	P51815	ZN75D_HUMAN	Homo sapiens zinc finger protein 75D (ZNF75D), transcript variant 1, mRNA.	197					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TTTCATATACAGGCTGGGTTT	0.463												
PASD1	139135	broad.mit.edu	37	X	150840069	150840069	+	Missense_Mutation	SNP	G	G	A			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:150840069G>A	uc004fev.4	+	12	1587	c.1255G>A	c.(1255-1257)Gtt>Att	p.V419I		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	Homo sapiens PAS domain containing 1 (PASD1), mRNA.	419						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					ATTACGCCACGTTGTCATTCC	0.498												
