Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYEOV	26579	broad.mit.edu	37	11	69063063	69063063	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr11:69063063T>C	ENST00000308946.3	+	3	596	c.146T>C	c.(145-147)gTc>gCc	p.V49A	MYEOV_ENST00000535407.1_5'UTR|MYEOV_ENST00000441339.2_Missense_Mutation_p.V49A	NM_138768.2	NP_620123.2	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	49										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		CTGTAGTCTGTCCCCCTTGGG	0.582000													4	151					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83119432	83119432	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:83119432C>G	ENST00000307792.3	-	2	741	c.274G>C	c.(274-276)Gag>Cag	p.E92Q	SEMA3E_ENST00000427262.1_Missense_Mutation_p.E32Q	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	92	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				TTCTATACCTCTTTATAGCCG	0.388000													26	24					0	0	1	0	0
MRPL15	29088	broad.mit.edu	37	8	55060054	55060054	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr8:55060054C>G	ENST00000260102.4	+	5	740	c.666C>G	c.(664-666)taC>taG	p.Y222*		NM_014175.3	NP_054894.1	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15	222					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)|skin(3)	10		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			ACCGTGGGTACCTGGCGGATC	0.433000													7	75					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33463111	33463111	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr9:33463111G>A	ENST00000455041.2	-	24	3114	c.3055C>T	c.(3055-3057)Ctt>Ttt	p.L1019F	NOL6_ENST00000379471.2_Intron|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	1071					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		TAGAAGAAAAGGGCCAGATCC	0.552000													11	19					0	0	1	0	0
C20orf112	140688	broad.mit.edu	37	20	31035489	31035489	+	Silent	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr20:31035489C>T	ENST00000359676.5	-	8	1363	c.1221G>A	c.(1219-1221)gtG>gtA	p.V407V		NM_001256798.1|NM_080616.4	NP_001243727.1|NP_542183.2	Q96MY1	CT112_HUMAN	chromosome 20 open reading frame 112	407										endometrium(3)|kidney(2)|large_intestine(5)|lung(5)	15						TGAGCTGCCGCACGGCGCTGA	0.672000													40	45					0	0	1	0	0
YY2	404281	broad.mit.edu	37	X	21875401	21875401	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chrX:21875401G>T	ENST00000429584.2	+	1	1297	c.799G>T	c.(799-801)Gat>Tat	p.D267Y	MBTPS2_ENST00000465888.1_3'UTR|MBTPS2_ENST00000379484.5_Intron|MBTPS2_ENST00000365779.2_Intron	NM_206923.3	NP_996806.2	O15391	TYY2_HUMAN	YY2 transcription factor	267	Mediates transcriptional repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	19						GATGTTCCGGGATTACGCCGC	0.498000													5	208					1.23904e-05	1.26926e-05	1	1	0
ERN2	10595	broad.mit.edu	37	16	23716446	23716446	+	Silent	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:23716446G>A	ENST00000256797.4	-	8	924	c.756C>T	c.(754-756)tgC>tgT	p.C252C	ERN2_ENST00000457008.2_Silent_p.C204C	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	204					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGCCCATCCCGCAGGACGCCA	0.647000													10	36					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49161202	49161202	+	Silent	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:49161202G>A	ENST00000418109.1	-	25	3920	c.3756C>T	c.(3754-3756)gcC>gcT	p.A1252A	LAMB2_ENST00000305544.4_Silent_p.A1252A	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1252	Domain II.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGTGGAGGCGGCTGAGGTGT	0.622000													30	85					0	0	1	0	0
RAB27A	5873	broad.mit.edu	37	15	55497845	55497845	+	Missense_Mutation	SNP	T	T	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr15:55497845T>A	ENST00000396307.2	-	6	777	c.526A>T	c.(526-528)Atg>Ttg	p.M176L	RAB27A_ENST00000564609.1_Missense_Mutation_p.M176L|RAB27A_ENST00000569493.1_Missense_Mutation_p.M176L|RAB27A_ENST00000336787.1_Missense_Mutation_p.M176L	NM_004580.4	NP_004571.2	P51159	RB27A_HUMAN	RAB27A, member RAS oncogene family	176					small GTPase mediated signal transduction	dendrite|exocytic vesicle|late endosome|lysosome|melanosome	GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|ovary(1)|skin(1)	9				all cancers(107;0.0273)|GBM - Glioblastoma multiforme(80;0.0993)		TCCAGAAGCATCTCAATTGCT	0.473000													59	46					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6241395	6241395	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr18:6241395G>T	ENST00000400104.3	-	8	714	c.514C>A	c.(514-516)Caa>Aaa	p.Q172K	L3MBTL4_ENST00000535782.1_5'UTR|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.Q172K|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.Q172K|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.Q172K			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	172					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				GGAGCATTTTGCAATTTGCAG	0.308000													76	10					2.65773e-34	2.86217e-34	1	1	0
TPTE2P6	0	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													6	29					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30638670	30638670	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:30638670C>T	ENST00000376442.3	-	3	701	c.506G>A	c.(505-507)cGt>cAt	p.R169H		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	169					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						AAGGCGTTCACGCTCTGTCCG	0.557000													4	71					0	0	1	0	0
EEF1A1	1915	broad.mit.edu	37	6	74229701	74229701	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:74229701C>T	ENST00000316292.9	-	1	1040	c.49G>A	c.(49-51)Gat>Aat	p.D17N	EEF1A1_ENST00000309268.6_Missense_Mutation_p.D17N|EEF1A1_ENST00000331523.2_Missense_Mutation_p.D17N	NM_001402.5	NP_001393.1	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha 1	17						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						TTGCCCGAATCTACGTGTCCA	0.423000													11	37					0	0	1	0	0
ZDHHC14	79683	broad.mit.edu	37	6	158068387	158068387	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:158068387C>A	ENST00000359775.5	+	7	1841	c.952C>A	c.(952-954)Ccc>Acc	p.P318T	ZDHHC14_ENST00000341375.8_3'UTR|ZDHHC14_ENST00000414563.2_Missense_Mutation_p.P318T			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	318						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		CCTGTGTGGGCCCATCTCACC	0.498000													56	39					1.73933e-33	1.84941e-33	1	1	0
PRSS3P2	0	broad.mit.edu	37	7	142481246	142481246	+	RNA	SNP	A	A	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:142481246A>G	ENST00000603901.1	+	0	320					NR_001296.3																						CTGAACAATGACATCATGCTG	0.527000													6	79					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33638268	33638268	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:33638268G>A	ENST00000374316.5	+	20	3416	c.2356G>A	c.(2356-2358)Gtg>Atg	p.V786M	ITPR3_ENST00000605930.1_Missense_Mutation_p.V786M			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	786					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GCACGTGCACGTGGACCGTGA	0.622000													73	51					0	0	1	0	0
KIRREL	55243	broad.mit.edu	37	1	158061183	158061183	+	Silent	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:158061183G>A	ENST00000368172.1	+	7	762	c.750G>A	c.(748-750)ggG>ggA	p.G250G	KIRREL_ENST00000392272.2_Silent_p.G333G|KIRREL_ENST00000359209.6_Silent_p.G436G|KIRREL_ENST00000416935.2_Silent_p.G336G|KIRREL_ENST00000360089.4_Silent_p.G272G|KIRREL_ENST00000368173.3_Silent_p.G452G			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	436	Ig-like C2-type 3.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					TGGAGGTGGGGACCCTGGAAC	0.572000													15	136					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999229	112999229	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:112999229T>C	ENST00000271277.6	+	6	1340	c.1115T>C	c.(1114-1116)gTg>gCg	p.V372A		NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	372						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAAACCAGGTGCCTCCACGG	0.522000													4	128					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129123129	129123129	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:129123129C>T	ENST00000505956.1	-	7	1529	c.1367G>A	c.(1366-1368)cGg>cAg	p.R456Q	EFCAB12_ENST00000326085.3_Missense_Mutation_p.R456Q	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GCCCTGGGACCGGAGCAGAGC	0.562000													31	123					0	0	1	0	0
DDX19A	55308	broad.mit.edu	37	16	70400656	70400656	+	Silent	SNP	T	T	C	rs142443034	byFrequency	TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:70400656T>C	ENST00000302243.7	+	9	1075	c.912T>C	c.(910-912)gaT>gaC	p.D304D	DDX19A_ENST00000417604.2_Silent_p.D273D|DDX19A_ENST00000443119.2_Silent_p.D214D	NM_018332.3	NP_060802.1			DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A											breast(1)|endometrium(1)|large_intestine(5)|lung(3)|urinary_tract(1)	11		Ovarian(137;0.221)				AGACCCTGGATACCATCAAGC	0.502000													29	115					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													6	54					0.0215528	0.0215528	1	1	0
ABCA7	10347	broad.mit.edu	37	19	1056090	1056090	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:1056090C>T	ENST00000263094.6	+	32	4495	c.4264C>T	c.(4264-4266)Cga>Tga	p.R1422*	ABCA7_ENST00000433129.1_Nonsense_Mutation_p.R1422*|ABCA7_ENST00000435683.2_Nonsense_Mutation_p.R1284*	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1422					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGGGGGCCGAGACCCAGG	0.726000													36	46					0	0	1	0	0
RNF34	80196	broad.mit.edu	37	12	121867855	121867855	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:121867855G>A	ENST00000392464.2	+	7	1151	c.1082G>A	c.(1081-1083)cGc>cAc	p.R361H	KDM2B_ENST00000377069.4_3'UTR|KDM2B_ENST00000377071.4_3'UTR|KDM2B_ENST00000542973.1_3'UTR|KDM2B_ENST00000536437.1_3'UTR			Q969K3	RNF34_HUMAN	ring finger protein 34, E3 ubiquitin protein ligase	15					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding			breast(1)|large_intestine(1)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		TGTAAAGGCCGCCTTAGAAAT	0.483000													8	61					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156726	26156726	+	Silent	SNP	T	T	A	rs148044098		TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:26156726T>A	ENST00000304218.3	+	1	168	c.108T>A	c.(106-108)tcT>tcA	p.S36S		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	36	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						GCAAAGCGTCTGGGCCCCCGG	0.662000													23	54					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	102					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48210912	48210912	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:48210912G>T	ENST00000394747.1	-	24	3810	c.3461C>A	c.(3460-3462)aCa>aAa	p.T1154K	ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000353782.5_Missense_Mutation_p.T1154K|ABCC11_ENST00000394748.1_Missense_Mutation_p.T1154K|ABCC11_ENST00000356608.2_Missense_Mutation_p.T1154K	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1154	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CACGGTGGGTGTGTTGTCTCT	0.557000													17	17					5.03518e-11	5.28694e-11	1	1	0
OR51B5	282763	broad.mit.edu	37	11	5364389	5364389	+	Silent	SNP	A	A	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr11:5364389A>T	ENST00000300773.2	-	1	420	c.366T>A	c.(364-366)atT>atA	p.I122I	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCAGATGGCAATAAAACGGT	0.463000													13	57					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223568629	223568629	+	Silent	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:223568629C>T	ENST00000366875.3	+	1	1915	c.1812C>T	c.(1810-1812)tcC>tcT	p.S604S		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	604										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		CCAACAGCTCCCTTGATCAGA	0.582000													25	37					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47147518	47147518	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:47147518T>C	ENST00000409792.3	-	6	4850	c.4808A>G	c.(4807-4809)cAt>cGt	p.H1603R		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1603	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GAAATAGTAATGGATGTTTTT	0.398000			"""N, F, S, Mis"""		clear cell renal carcinoma								22	100					0	0	1	0	0
HAUS1	115106	broad.mit.edu	37	18	43685266	43685266	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr18:43685266T>G	ENST00000282058.6	+	2	217	c.137T>G	c.(136-138)gTc>gGc	p.V46G	HAUS1_ENST00000585518.1_Missense_Mutation_p.V46G	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	46					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						CGCAACAGGGTCCGGGACAGG	0.438000													25	5					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38884668	38884668	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr21:38884668G>A	ENST00000339659.3	+	11	3569	c.2099G>A	c.(2098-2100)cGc>cAc	p.R700H	DYRK1A_ENST00000455387.2_Missense_Mutation_p.R481H|DYRK1A_ENST00000338785.3_3'UTR|DYRK1A_ENST00000398960.2_Missense_Mutation_p.R709H	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	709					nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						TCCAATCCCCGCCAAGAGACT	0.488000													28	53					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147108875	147108875	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:147108875T>C	ENST00000383075.3	-	4	1359	c.847A>G	c.(847-849)Aag>Gag	p.K283E	ZIC4_ENST00000484399.1_Missense_Mutation_p.K283E|ZIC4_ENST00000473123.1_Missense_Mutation_p.K283E|ZIC4_ENST00000525172.2_Missense_Mutation_p.K333E|ZIC4_ENST00000472749.2_5'UTR|ZIC4_ENST00000425731.3_Missense_Mutation_p.K321E|ZIC4_ENST00000491672.1_Missense_Mutation_p.K77E	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	283						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TTCATGTGCTTACGCAGCGAG	0.642000													23	61					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17250900	17250900	+	Missense_Mutation	SNP	G	G	A	rs140882535		TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:17250900G>A	ENST00000375541.5	+	3	346	c.277G>A	c.(277-279)Gtg>Atg	p.V93M	CROCC_ENST00000467938.1_Intron	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	93					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCTGTCCCGCGTGGAGGACCT	0.657000													19	24					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189026001	189026001	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr4:189026001G>A	ENST00000512729.1	-	2	499	c.125C>T	c.(124-126)gCg>gTg	p.A42V	TRIML2_ENST00000326754.3_Missense_Mutation_p.A42V|TRIML2_ENST00000536972.1_Missense_Mutation_p.A92V	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	42							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CTGAATCATCGCCATTCTTTC	0.363000													16	65					0	0	1	0	0
ZNF812	729648	broad.mit.edu	37	19	9801052	9801052	+	Missense_Mutation	SNP	C	C	T	rs115285977	by1000genomes	TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:9801052C>T	ENST00000457674.2	-	5	1645	c.1127G>A	c.(1126-1128)cGt>cAt	p.R376H	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATGTTTACTACGATAGGAAGA	0.388000													33	32					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								26	31					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139734050	139734050	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:139734050G>A	ENST00000263549.3	-	8	2279	c.1406C>T	c.(1405-1407)aCg>aTg	p.T469M	PARP12_ENST00000470515.1_5'UTR	NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	469						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					TTGCATGGTCGTCACATCCTG	0.493000													13	21					0	0	1	0	0
TAAR2	9287	broad.mit.edu	37	6	132939136	132939136	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:132939136T>C	ENST00000275191.2	-	1	181	c.74A>G	c.(73-75)tAc>tGc	p.Y25C	TAAR2_ENST00000367931.1_Missense_Mutation_p.Y70C|TAAR2_ENST00000537809.1_Missense_Mutation_p.Y25C	NM_014626.3	NP_055441.2	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2	70						plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)	23	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		CTGCTTGAAGTAGGAAATGGA	0.428000													10	59					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71974137	71974137	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:71974137A>G	ENST00000266674.5	+	16	1797	c.1486A>G	c.(1486-1488)Aat>Gat	p.N496D	LGR5_ENST00000536515.1_Missense_Mutation_p.N424D|LGR5_ENST00000540815.2_Missense_Mutation_p.N472D			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	496						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TAATCAATGGAATAAAGGTGA	0.393000													31	205					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134128882	134128882	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr8:134128882A>G	ENST00000220616.4	+	45	7824	c.7784A>G	c.(7783-7785)gAc>gGc	p.D2595G	TG_ENST00000542445.1_Missense_Mutation_p.D965G|TG_ENST00000519543.1_Missense_Mutation_p.D728G|TG_ENST00000377869.1_Missense_Mutation_p.D2538G	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2595					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCTATAATCGACATGGCCAGT	0.537000													52	59					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13600893	13600893	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr4:13600893C>T	ENST00000040738.5	-	10	7766	c.7631G>A	c.(7630-7632)gGg>gAg	p.G2544E		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2544							DNA binding										AGCCACGGTCCCTTGAACAGG	0.493000											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	9					0	0	1	0	0
IGLV3-12	0	broad.mit.edu	37	22	23114830	23114830	+	RNA	SNP	A	A	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr22:23114830A>G	ENST00000390313.2	+	0	111																											TGGCCACAGCACAGATGGCCA	0.498000													10	16					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21817119	21817119	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr5:21817119C>A	ENST00000382254.1	-	9	2023	c.937G>T	c.(937-939)Ggg>Tgg	p.G313W	CDH12_ENST00000504376.2_Missense_Mutation_p.G313W|CDH12_ENST00000522262.1_Missense_Mutation_p.G273W|CDH12_ENST00000521384.1_5'UTR	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	313	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AAATTTCCCCCATCTCCTGGA	0.383000										HNSCC(59;0.17)			43	49					1.31131e-34	1.43051e-34	1	1	0
CMAS	55907	broad.mit.edu	37	12	22199458	22199458	+	Missense_Mutation	SNP	G	G	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:22199458G>C	ENST00000229329.2	+	1	351	c.221G>C	c.(220-222)tGg>tCg	p.W74S		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	74					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						CTCATTGGCTGGGTCCTGCGT	0.692000													14	22					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156846352	156846352	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:156846352A>G	ENST00000368196.3	+	13	1895	c.1775A>G	c.(1774-1776)aAc>aGc	p.N592S	NTRK1_ENST00000524377.1_Missense_Mutation_p.N598S|NTRK1_ENST00000358660.3_Missense_Mutation_p.N595S|NTRK1_ENST00000392302.2_Missense_Mutation_p.N562S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	598	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGGGACCTCAACCGCTTCCTC	0.642000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			11	22					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	109807	109807	+	Silent	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:109807G>A	ENST00000262316.6	-	14	1882	c.1740C>T	c.(1738-1740)agC>agT	p.S580S		NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	580					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity	p.S580S(1)		breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GGTTCCCAGCGCTGTTTTTGG	0.592000													21	23					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46660106	46660106	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:46660106T>C	ENST00000544460.1	+	1	4495	c.4241T>C	c.(4240-4242)tTg>tCg	p.L1414S	TDRD6_ENST00000316081.6_Missense_Mutation_p.L1414S	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1414					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TTGCCGGGGTTGTGCATTCAT	0.408000													76	122					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107032445	107032445	+	Splice_Site	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:107032445T>C	ENST00000409886.3	-	21	5012	c.4924_splice	c.e21-1	p.E1642_splice	RGPD3_ENST00000304514.7_Splice_Site_p.E1642_splice	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1642					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TAATGGAGGCTCTGCAACATG	0.328000													13	65					0	0	1	0	0
LILRB1	0	broad.mit.edu	37	19	55143565	55143565	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:55143565G>A	ENST00000396331.1	+	6	895	c.538G>A	c.(538-540)Gcc>Acc	p.A180T	LILRB1_ENST00000396321.2_Missense_Mutation_p.A180T|LILRB1_ENST00000427581.2_Missense_Mutation_p.A216T|LILRB1_ENST00000396317.1_Missense_Mutation_p.A180T|LILRB1_ENST00000396327.3_Missense_Mutation_p.A180T|LILRB1_ENST00000324602.7_Missense_Mutation_p.A180T|LILRB1_ENST00000396332.4_Missense_Mutation_p.A180T|LILRB1_ENST00000434867.2_Missense_Mutation_p.A180T|LILRB1_ENST00000418536.2_Missense_Mutation_p.A180T|LILRB1_ENST00000448689.1_Missense_Mutation_p.A180T|LILRB1_ENST00000396315.1_Missense_Mutation_p.A180T	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	180	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GTCGTCCCGCGCCATCTTCTC	0.577000										HNSCC(37;0.09)			86	21					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51751835	51751835	+	Splice_Site	SNP	T	T	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:51751835T>A	ENST00000395052.3	+	5	2779		c.e5+2		GRM2_ENST00000442933.2_Splice_Site|GRM2_ENST00000475478.1_Splice_Site	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2						synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TTGGCCAAGGTCAGTGTCCTA	0.622000													20	42					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35902074	35902074	+	Splice_Site	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:35902074C>T	ENST00000339208.6	-	15	3342	c.3202_splice	c.e15+1	p.G1068_splice	SYNRG_ENST00000394378.2_Splice_Site_p.G990_splice|SYNRG_ENST00000346661.4_Splice_Site_p.G1068_splice|SYNRG_ENST00000345615.4_Splice_Site_p.G990_splice|SYNRG_ENST00000591288.1_Splice_Site_p.G862_splice|SYNRG_ENST00000585472.1_Splice_Site_p.G989_splice|SYNRG_ENST00000502449.2_Splice_Site_p.G945_splice	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	1068					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGCTACTCACCTTGAACAGAA	0.373000													56	78					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72700686	72700686	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:72700686T>C	ENST00000469092.1	-	3	598	c.322A>G	c.(322-324)Act>Gct	p.T108A	CD300LF_ENST00000583937.1_Missense_Mutation_p.T105A|CD300LF_ENST00000464910.1_Missense_Mutation_p.T108A|CD300LF_ENST00000301573.9_Missense_Mutation_p.T105A|CD300LF_ENST00000581500.1_Missense_Mutation_p.T108A|CD300LF_ENST00000326165.6_Missense_Mutation_p.T105A|RAB37_ENST00000402449.4_Intron|RAB37_ENST00000340415.3_Intron|CD300LF_ENST00000343125.4_Missense_Mutation_p.T108A|CD300LF_ENST00000361254.4_Missense_Mutation_p.T108A			Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	105	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CACCAGTAAGTGTCAGCATCA	0.478000													86	120					0	0	1	0	0
UGT1A8	0	broad.mit.edu	37	2	234526858	234526858	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:234526858G>A	ENST00000373450.4	+	1	568	c.505G>A	c.(505-507)Gcc>Acc	p.A169T		NM_019076.4	NP_061949.3														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGTGGTCTTCGCCAGGGGAAT	0.468000													64	126					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													6	49					0	0	1	0	0
TEAD3	7005	broad.mit.edu	37	6	35454437	35454437	+	Translation_Start_Site	SNP	T	T	C			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:35454437T>C	ENST00000402886.3	-	0	104				TEAD3_ENST00000338863.7_Missense_Mutation_p.I1M			Q99594	TEAD3_HUMAN	TEA domain family member 3						female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	10						TGTTGGACGCTATTGTGCTGG	0.682000													3	71					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435787	158435787	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:158435787G>A	ENST00000289451.2	+	1	516	c.436G>A	c.(436-438)Gct>Act	p.A146T		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	146					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					GGGACTAATGGCTGCTGCCTG	0.552000													15	234					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172549335	172549335	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:172549335C>T	ENST00000534253.2	+	3	325	c.157C>T	c.(157-159)Ctt>Ttt	p.L53F	DYNC1I2_ENST00000409197.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.L53F|DYNC1I2_ENST00000397119.3_Missense_Mutation_p.L53F|DYNC1I2_ENST00000409317.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.L53F|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.L53F|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.L53F|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.L53F			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	53					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			AGAATCAGATCTTGAAAAAAA	0.353000													6	8					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43897195	43897195	+	Splice_Site	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:43897195G>A	ENST00000562955.1	+	34	4917		c.e34+1		SZT2_ENST00000372442.1_Splice_Site	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)							peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CATGAATGAGGTGAGCCCCCC	0.498000													81	10					0	0	1	0	0
DDX19B	11269	broad.mit.edu	37	16	70363827	70363827	+	Silent	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:70363827C>T	ENST00000288071.6	+	9	1124	c.879C>T	c.(877-879)aaC>aaT	p.N293N	DDX19B_ENST00000355992.3_Silent_p.N262N|DDX19B_ENST00000393657.2_Silent_p.N184N|DDX19B_ENST00000568625.1_Silent_p.N184N|RP11-529K1.2_ENST00000562077.1_RNA|DDX19B_ENST00000563392.1_Silent_p.N184N|DDX19B_ENST00000451014.3_Silent_p.N267N|RP11-529K1.3_ENST00000567706.1_Intron|DDX19B_ENST00000563206.1_Silent_p.N298N	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	293	Helicase ATP-binding.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				CAGACCCAAACGTTATCAAAC	0.527000													4	150					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217736	150217736	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:150217736C>T	ENST00000313543.4	+	2	831	c.674C>T	c.(673-675)aCt>aTt	p.T225I		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	225							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAAATCTACACTGACCAATTA	0.343000													37	51					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													6	56					0	0	1	0	0
C20orf112	140688	broad.mit.edu	37	20	31035488	31035488	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr20:31035488G>A	ENST00000359676.5	-	8	1364	c.1222C>T	c.(1222-1224)Cgg>Tgg	p.R408W		NM_001256798.1|NM_080616.4	NP_001243727.1|NP_542183.2	Q96MY1	CT112_HUMAN	chromosome 20 open reading frame 112	408										endometrium(3)|kidney(2)|large_intestine(5)|lung(5)	15						ATGAGCTGCCGCACGGCGCTG	0.667000													40	45					0	0	1	0	0
LYPD6B	130576	broad.mit.edu	37	2	150064872	150064872	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:150064872G>A	ENST00000409642.3	+	5	675	c.274G>A	c.(274-276)Gca>Aca	p.A92T	LYPD6B_ENST00000280115.7_Missense_Mutation_p.A92T|LYPD6B_ENST00000409029.1_Missense_Mutation_p.A68T|LYPD6B_ENST00000409876.1_Missense_Mutation_p.A68T|LYPD6B_ENST00000498249.1_3'UTR	NM_177964.3	NP_808879.2	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	68	UPAR/Ly6.					anchored to membrane|plasma membrane				endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11						TTGTGAAAACGCAGGGGATAA	0.373000													44	44					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95768289	95768289	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr8:95768289T>G	ENST00000414645.2	+	7	736	c.637T>G	c.(637-639)Tcc>Gcc	p.S213A		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	213						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					AATTGAATACTCCATTCCTTT	0.313000													46	46					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088048	86088048	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr14:86088048G>A	ENST00000330753.4	+	2	957	c.190G>A	c.(190-192)Ggc>Agc	p.G64S	FLRT2_ENST00000554746.1_Missense_Mutation_p.G64S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	64					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GATCCCGGAGGGCGTAACTGT	0.517000													81	90					0	0	1	0	0
SLC2A4RG	56731	broad.mit.edu	37	20	62372750	62372750	+	Silent	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr20:62372750C>T	ENST00000266077.2	+	3	361	c.309C>T	c.(307-309)gaC>gaT	p.D103D	SLC2A4RG_ENST00000493772.1_3'UTR	NM_020062.3	NP_064446.2	Q9NR83	S2A4R_HUMAN	SLC2A4 regulator	103						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|lung(2)|prostate(2)|skin(1)	7	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					CCCGGCTGGACGAGGTCATGG	0.677000													8	99					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921479	24921479	+	Missense_Mutation	SNP	A	A	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr15:24921479A>T	ENST00000329468.2	+	1	939	c.465A>T	c.(463-465)gaA>gaT	p.E155D		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GGGCCCAAGAAGGGCCCAGAA	0.602000													5	60					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120966794	120966794	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:120966794C>T	ENST00000288532.6	-	1	191	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	COQ5_ENST00000445328.2_Missense_Mutation_p.E51K	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	51					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAGTGCGTTTCCGCTGCCCGC	0.632000													29	175					0	0	1	0	0
HYAL1	3373	broad.mit.edu	37	3	50338477	50338477	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:50338477G>A	ENST00000266031.4	-	2	1547	c.932C>T	c.(931-933)gCg>gTg	p.A311V	HYAL1_ENST00000395144.2_Missense_Mutation_p.A311V|HYAL1_ENST00000395143.2_Intron|HYAL1_ENST00000320295.8_Missense_Mutation_p.A311V|HYAL1_ENST00000457214.2_Missense_Mutation_p.A129V|HYAL1_ENST00000447605.2_Missense_Mutation_p.A52V			Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1	311						extracellular space|lysosome	hyalurononglucosaminidase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	CCCCTGGGCCGCACTCTCCCC	0.627000													3	38					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	7888162	7888162	+	Silent	SNP	C	C	A			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr18:7888162C>A	ENST00000332175.8	+	3	1292	c.255C>A	c.(253-255)ctC>ctA	p.L85L	PTPRM_ENST00000400053.4_Silent_p.L23L|PTPRM_ENST00000400060.4_Silent_p.L85L|PTPRM_ENST00000580170.1_Silent_p.L85L	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	85	MAM.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				CCCACCTGCTCTTACCCCAAC	0.463000													4	138					0.00909568	0.00920527	1	1	0
RBM46	166863	broad.mit.edu	37	4	155720132	155720132	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr4:155720132A>G	ENST00000510397.1	+	4	997	c.818A>G	c.(817-819)tAt>tGt	p.Y273C	RBM46_ENST00000281722.3_Missense_Mutation_p.Y273C|RBM46_ENST00000514866.1_Missense_Mutation_p.Y273C	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	273	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				CTTAGAGATTATGCTTTTGTT	0.363000													14	13					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52643673	52643673	+	Silent	SNP	C	C	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:52643673C>T	ENST00000356770.4	-	15	2129	c.2127G>A	c.(2125-2127)ccG>ccA	p.P709P	PBRM1_ENST00000409767.1_Silent_p.P756P|PBRM1_ENST00000409114.3_Silent_p.P756P|PBRM1_ENST00000409057.1_Silent_p.P741P|PBRM1_ENST00000337303.4_Silent_p.P741P|PBRM1_ENST00000410007.1_Silent_p.P741P|PBRM1_ENST00000394830.3_Silent_p.P741P|PBRM1_ENST00000296302.7_Silent_p.P741P			Q86U86	PB1_HUMAN	polybromo 1	741	Bromo 5.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCAAAGACTCCGGCTCATTGT	0.423000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								11	84					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629728	47629728	+	Silent	SNP	A	A	G			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:47629728A>G	ENST00000546455.1	+	4	1613	c.882A>G	c.(880-882)ttA>ttG	p.L294L	PCED1B_ENST00000432328.1_Silent_p.L294L					PC-esterase domain containing 1B																		ccccacccttaccttccccca	0.642000													11	32					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101738436	101738436	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:101738436G>T	ENST00000261637.4	+	36	4687	c.4513G>T	c.(4513-4515)Gct>Tct	p.A1505S		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1505				A -> P (in Ref. 1; CAA07243).	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						CAAAAAGCTAGCTGCCTTGAA	0.373000													4	93					1.23904e-05	1.26926e-05	1	1	0
SETD2	29072	broad.mit.edu	37	3	47088034	47088035	+	Frame_Shift_Ins	INS	-	-	TGTA			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:47088034_47088035insTGTA	ENST00000409792.3	-	16	7082_7083	c.7040_7041insTACA	c.(7039-7041)cccfs	p.P2347fs		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2347	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTGCGGCTGGCTGTACCACCAC	0.455			"""N, F, S, Mis"""		clear cell renal carcinoma								28	39	---	---	---	---					
DNAH12	201625	broad.mit.edu	37	3	57509313	57509313	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:57509313delT	ENST00000351747.2	-	4	456	c.276delA	c.(274-276)aafs	p.K92fs	DNAH12_ENST00000389536.4_Frame_Shift_Del_p.K92fs|DNAH12_ENST00000311202.6_Frame_Shift_Del_p.K92fs	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	92	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.G93fs*7(2)		breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						AACTCACTCCTTTTTTTTTCA	0.254													3	5	---	---	---	---					
DPY19L2P2	0	broad.mit.edu	37	7	102902926	102902926	+	RNA	DEL	A	A	-			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:102902926delA	ENST00000312132.4	-	0	2401																											TTAAAACATGAAAAaaaaagg	0.383													2	4	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57572242	57572242	+	Frame_Shift_Del	DEL	G	G	-	rs139915490		TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:57572242delG	ENST00000243077.3	+	27	4928	c.4462delG	c.(4462-4464)ggfs	p.G1489fs		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1489					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGCTGTACGGGGGGGAGGT	0.587													8	167	---	---	---	---					
RB1	5925	broad.mit.edu	37	13	48936948	48936966	+	Splice_Site	DEL	CAGAAACAGCTGTTATACC	CAGAAACAGCTGTTATACC	-	rs147754935	byFrequency	TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr13:48936948_48936966delCAGAAACAGCTGTTATACC	ENST00000267163.4	+	8	856_872	c.718_splice	c.e8-1	p.240_splice		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	240					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)|p.K240_A242>T(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCACTTTTACAGAAACAGCTGTTATACCCATTAATGGT	0.338		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			11	7	---	---	---	---					
RNASEH2B	79621	broad.mit.edu	37	13	51530586	51530587	+	Frame_Shift_Ins	INS	-	-	A	rs75254367		TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr13:51530586_51530587insA	ENST00000336617.3	+	11	1314_1315	c.915_916insA	c.(913-918)aaaaaafs	p.KK305fs	RNASEH2B_ENST00000422660.1_Intron|RNASEH2B_ENST00000495244.2_3'UTR	NM_024570.3	NP_078846.2	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B	305					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		GGGTAAAAAATAAAAAAAAAAT	0.297													7	0	---	---	---	---					
TMEM121	80757	broad.mit.edu	37	14	105996050	105996052	+	In_Frame_Del	DEL	GCC	GCC	-	rs5811180		TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr14:105996050_105996052delGCC	ENST00000392519.2	+	2	1043_1045	c.879_881delGCC	c.(877-882)gtg>gt	p.VP293del	TMEM121_ENST00000431372.1_In_Frame_Del_p.VP293del	NM_025268.2	NP_079544.1	Q9BTD3	TM121_HUMAN	transmembrane protein 121	293	Pro-rich.					integral to membrane				endometrium(2)|lung(1)	3		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.0959)|all cancers(159;0.235)		GCAACTCGGTgccgccgccgccg	0.768													2	4	---	---	---	---					
YIPF2	78992	broad.mit.edu	37	19	11038362	11038364	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:11038362_11038364delGCT	ENST00000586748.1	-	4	393_395	c.221_223delAGC	c.(220-225)ccg>c	p.QP74del	YIPF2_ENST00000253031.2_In_Frame_Del_p.QP74del|YIPF2_ENST00000590329.1_In_Frame_Del_p.QP74del			Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	74						integral to membrane|transport vesicle				cervix(1)|endometrium(1)|lung(3)|ovary(2)	7						CAGAATCCCGgctgctgctgctg	0.621													8	132	---	---	---	---					
ZNF780B	163131	broad.mit.edu	37	19	40541052	40541052	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DH-A669-01A-12D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	425bf16e-aeb2-453a-932b-b3f59016b041	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:40541052delG	ENST00000434248.1	-	5	1779	c.1714delC	c.(1714-1716)ttfs	p.L572fs	ZNF780B_ENST00000221355.6_Frame_Shift_Del_p.L424fs	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGTTGATTAAGATTTGAACCA	0.383													10	94	---	---	---	---					
