Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CUX2	23316	broad.mit.edu	37	12	111748437	111748437	+	Silent	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr12:111748437G>A	ENST00000261726.6	+	15	2005	c.1851G>A	c.(1849-1851)tcG>tcA	p.S617S		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	617						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						AGTTCCTGTCGGATGAGCAGA	0.652000													27	28					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35037113	35037113	+	Silent	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr5:35037113G>A	ENST00000231420.6	-	4	620	c.420C>T	c.(418-420)gtC>gtT	p.V140V		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	140			V -> I (in dbSNP:rs37369).		glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GGTGGAAGAAGACGGTGCTTG	0.517000													7	59					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3214422	3214422	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr4:3214422G>A	ENST00000355072.5	+	49	6905	c.6760G>A	c.(6760-6762)Gtg>Atg	p.V2254M		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2254					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GAAATTCGTGGTGGCAACCCT	0.547000													15	74					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52886575	52886575	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr12:52886575C>T	ENST00000330722.6	-	1	466	c.398G>A	c.(397-399)gGa>gAa	p.G133E		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	133	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		TTGGATGCCTCCAGGGGGGCA	0.632000													22	23					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279830	46279830	+	Silent	SNP	G	G	A	rs147918555		TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr20:46279830G>A	ENST00000372004.3	+	20	3960	c.3744G>A	c.(3742-3744)caG>caA	p.Q1248Q	NCOA3_ENST00000371997.3_Silent_p.Q1243Q|NCOA3_ENST00000341724.6_Silent_p.Q1178Q|NCOA3_ENST00000371998.3_Silent_p.Q1252Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1252	Acetyltransferase.|Poly-Gln.		Missing.		androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1252Q(3)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.547000													6	54					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1570263	1570263	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr16:1570263T>C	ENST00000426508.2	-	28	4105	c.3742A>G	c.(3742-3744)Atc>Gtc	p.I1248V	IFT140_ENST00000361339.5_Missense_Mutation_p.I442V	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	1248										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				GCAGCCATGATGTAGATTTCC	0.577000													50	65					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161143573	161143573	+	Silent	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr6:161143573G>A	ENST00000308192.9	+	10	1293	c.1230G>A	c.(1228-1230)caG>caA	p.Q410Q		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	410	Kringle 4.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACCGGCACCAGAAGACCCCAG	0.483000													12	151					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162275516	162275516	+	Silent	SNP	C	C	T			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr2:162275516C>T	ENST00000389554.3	+	4	1400	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	TBR1_ENST00000410035.1_Silent_p.F74F	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	361						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						CGTTCACTTTCCCTGAGACTC	0.632000													43	72					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131893129	131893129	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr5:131893129A>G	ENST00000265335.6	+	1	500	c.113A>G	c.(112-114)aAt>aGt	p.N38S	RAD50_ENST00000378823.3_5'UTR			Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	38					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTTGGACCCAATGGGGCGGGA	0.453000								Homologous recombination					22	33					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245244	183245244	+	Missense_Mutation	SNP	C	C	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr4:183245244C>A	ENST00000511685.1	+	2	194	c.71C>A	c.(70-72)aCa>aAa	p.T24K	TENM3_ENST00000406950.2_Missense_Mutation_p.T24K					teneurin transmembrane protein 3																		CGGCGCTACACAAATTCCTCC	0.517000													4	33					0.014758	0.014758	1	1	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000371997.3_Silent_p.Q1253Q|NCOA3_ENST00000341724.6_Silent_p.Q1188Q|NCOA3_ENST00000371998.3_Silent_p.Q1262Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													5	30					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48646633	48646633	+	Silent	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr17:48646633G>A	ENST00000352832.5	+	3	834	c.462G>A	c.(460-462)cgG>cgA	p.R154R	CACNA1G_ENST00000510115.1_Silent_p.R154R|CACNA1G_ENST00000502264.1_Silent_p.R154R|CACNA1G_ENST00000510366.1_Silent_p.R154R|CACNA1G_ENST00000358244.5_Silent_p.R154R|CACNA1G_ENST00000442258.2_Silent_p.R154R|CACNA1G_ENST00000360761.4_Silent_p.R154R|CACNA1G_ENST00000354983.4_Silent_p.R154R|CACNA1G_ENST00000507896.1_Silent_p.R154R|CACNA1G_ENST00000429973.2_Silent_p.R154R|CACNA1G_ENST00000507510.2_Silent_p.R154R|CACNA1G_ENST00000507609.1_Silent_p.R154R|CACNA1G_ENST00000507336.1_Silent_p.R154R|CACNA1G_ENST00000514181.1_Silent_p.R154R|CACNA1G_ENST00000512389.1_Silent_p.R154R|CACNA1G_ENST00000505165.1_Silent_p.R154R|CACNA1G_ENST00000416767.4_Silent_p.R154R|CACNA1G_ENST00000515765.1_Silent_p.R154R|CACNA1G_ENST00000503485.1_Silent_p.R154R|CACNA1G_ENST00000515411.1_Silent_p.R154R|CACNA1G_ENST00000515165.1_Silent_p.R154R|CACNA1G_ENST00000514717.1_Silent_p.R154R|CACNA1G_ENST00000513964.1_Silent_p.R154R|CACNA1G_ENST00000514079.1_Silent_p.R154R|CACNA1G_ENST00000513689.2_Silent_p.R154R|CACNA1G_ENST00000359106.5_Silent_p.R154R	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	154					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CTTGGAACCGGCTTGACTTTT	0.562000													4	65					0	0	1	0	0
CCS	9973	broad.mit.edu	37	11	66368006	66368006	+	Nonsense_Mutation	SNP	C	C	T			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr11:66368006C>T	ENST00000533244.1	+	5	916	c.475C>T	c.(475-477)Cag>Tag	p.Q159*	CCS_ENST00000310190.4_Nonsense_Mutation_p.Q140*	NM_005125.1	NP_005116.1	O14618	CCS_HUMAN	copper chaperone for superoxide dismutase	159	Superoxide dismutase-like.				intracellular copper ion transport|oxidation-reduction process|removal of superoxide radicals	cytosol|mitochondrial inner membrane|nucleus|soluble fraction	copper ion transmembrane transporter activity|protein binding|superoxide dismutase copper chaperone activity|zinc ion binding			breast(2)|cervix(1)|large_intestine(2)|lung(3)|stomach(1)	9						TGGGGGCCCCCAGGACTCTGA	0.562000													4	70					0	0	1	0	0
TRBV6-5	0	broad.mit.edu	37	7	142180997	142180997	+	RNA	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr7:142180997G>A	ENST00000390368.2	-	0	19																											GTGCATTGATGAAAGGGGAGC	0.592000													3	27					0	0	1	0	0
GEMIN4	50628	broad.mit.edu	37	17	648477	648477	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr17:648477A>G	ENST00000576778.1	-	1	4114	c.2773T>C	c.(2773-2775)Tgg>Cgg	p.W925R	GEMIN4_ENST00000319004.5_Missense_Mutation_p.W936R			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	936					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		ACGTGGTTCCAGCCTTCCAGA	0.577000													2	2					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								20	35					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158596678	158596678	+	Silent	SNP	A	A	G			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr1:158596678A>G	ENST00000368148.3	-	41	5964	c.5784T>C	c.(5782-5784)taT>taC	p.Y1928Y	SPTA1_ENST00000368147.3_Silent_p.Y1925Y|SPTA1_ENST00000461624.1_5'UTR	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1928					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCTGAAAGGCATAATCGTCTT	0.438000													70	84					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28909640	28909640	+	Silent	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr16:28909640G>A	ENST00000395503.4	+	14	1816	c.1632G>A	c.(1630-1632)aaG>aaA	p.K544K	ATP2A1_ENST00000536376.1_Silent_p.K419K|ATP2A1_ENST00000357084.3_Silent_p.K544K	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	544					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						TGAAGGAAAAGATCATGGCGG	0.652000													6	84					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29631557	29631557	+	Missense_Mutation	SNP	A	A	G	rs11525721	by1000genomes	TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr20:29631557A>G	ENST00000278882.3	+	7	733	c.353A>G	c.(352-354)aAa>aGa	p.K118R	FRG1B_ENST00000358464.4_Missense_Mutation_p.K118R														p.K118R(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGTGCTGAAAAAGAAACCAAG	0.333000													3	42					0	0	1	0	0
INPP4B	8821	broad.mit.edu	37	4	143094935	143094935	+	Silent	SNP	T	T	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr4:143094935T>A	ENST00000513000.1	-	17	1642	c.1209A>T	c.(1207-1209)tcA>tcT	p.S403S	INPP4B_ENST00000262992.4_Silent_p.S403S|INPP4B_ENST00000308502.4_Silent_p.S403S|INPP4B_ENST00000508116.1_Silent_p.S403S|INPP4B_ENST00000509777.1_Silent_p.S403S	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	403					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TGTTTTCAGGTGAATAGTAAA	0.383000													36	66					0	0	1	0	0
MC2R	0	broad.mit.edu	37	18	13884744	13884744	+	Silent	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr18:13884744G>A	ENST00000327606.3	-	2	954	c.774C>T	c.(772-774)ttC>ttT	p.F258F		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	258					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	CGTTCACCTGGAAGAGAGACA	0.517000													29	30					0	0	1	0	0
NEDD4	4734	broad.mit.edu	37	15	56132818	56132818	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr15:56132818C>T	ENST00000508342.1	-	16	3502	c.3203G>A	c.(3202-3204)gGc>gAc	p.G1068D	NEDD4_ENST00000338963.2_Missense_Mutation_p.G996D|NEDD4_ENST00000435532.3_Missense_Mutation_p.G649D|NEDD4_ENST00000506154.1_Missense_Mutation_p.G1052D			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	1068	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		CAACAGTTTGCCATGATAAAC	0.338000													4	115					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	218					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27216911	27216911	+	Missense_Mutation	SNP	G	G	A	rs149942995		TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr6:27216911G>A	ENST00000230582.3	+	4	385	c.370G>A	c.(370-372)Gcc>Acc	p.A124T	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	124					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity	p.A124T(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						AGCCTGGGGCGCCCTGGTGAT	0.592000													7	65					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36121334	36121334	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr4:36121334C>T	ENST00000303965.4	-	24	4390	c.3901G>A	c.(3901-3903)Gaa>Aaa	p.E1301K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1301					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						ACTTGATCTTCTTTAACCTGT	0.299000													19	55					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55113495	55113495	+	Silent	SNP	C	C	T			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr6:55113495C>T	ENST00000370862.3	+	2	618	c.282C>T	c.(280-282)gtC>gtT	p.V94V		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	94					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACTTCATAGTCAATCTTTCTC	0.453000													5	189					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13670699	13670699	+	Missense_Mutation	SNP	G	G	A	rs111284875		TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr3:13670699G>A	ENST00000404922.3	+	13	2868	c.2749G>A	c.(2749-2751)Ggt>Agt	p.G917S	FBLN2_ENST00000535798.1_Missense_Mutation_p.G896S|FBLN2_ENST00000492059.1_Missense_Mutation_p.G917S|FBLN2_ENST00000295760.7_Missense_Mutation_p.G870S	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	913	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GCACCGCTGCGGTGAGGGCCA	0.642000													10	27					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72156845	72156845	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr8:72156845T>C	ENST00000340726.3	-	12	1772	c.1133A>G	c.(1132-1134)gAc>gGc	p.D378G	EYA1_ENST00000388743.2_Missense_Mutation_p.D377G|EYA1_ENST00000388742.4_Missense_Mutation_p.D378G|EYA1_ENST00000388741.2_Missense_Mutation_p.D344G|EYA1_ENST00000419131.1_Intron|EYA1_ENST00000388740.3_Missense_Mutation_p.D345G|EYA1_ENST00000303824.7_Missense_Mutation_p.D372G	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	378					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TACTTCTAAGTCATTAAAAAA	0.279000													9	15					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031030	32031030	+	Silent	SNP	T	T	C			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr3:32031030T>C	ENST00000360311.4	+	2	1008	c.459T>C	c.(457-459)gaT>gaC	p.D153D		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						CTATCAAAGATCAGCTTGGAT	0.398000													39	51					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995803	19995803	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr18:19995803G>A	ENST00000391403.2	-	1	2075	c.1972C>T	c.(1972-1974)Cct>Tct	p.P658S		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	658	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					ACAAAGCCAGGGCCAGTTGCT	0.463000													10	278					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7576615	7576615	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr6:7576615C>T	ENST00000379802.3	+	19	3060	c.2719C>T	c.(2719-2721)Cgc>Tgc	p.R907C	DSP_ENST00000418664.2_Missense_Mutation_p.R907C	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	907	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGATGCTAAACGCCGCCAGGA	0.423000													32	40					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121676713	121676713	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr7:121676713T>C	ENST00000393386.2	+	18	5755	c.5344T>C	c.(5344-5346)Tat>Cat	p.Y1782H	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.Y915H	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1782	Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ACTGACTGATTATATCAATGC	0.303000													21	28					0	0	1	0	0
TMEM41A	90407	broad.mit.edu	37	3	185212517	185212518	+	Frame_Shift_Ins	INS	-	-	A	rs150885877	byFrequency	TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr3:185212517_185212518insA	ENST00000421852.1	-	4	562_563	c.467_468insT	c.(466-468)tttfs	p.F156fs	TMEM41A_ENST00000296254.3_Intron|TMEM41A_ENST00000475480.1_5'UTR	NM_080652.3	NP_542383.1	Q96HV5	TM41A_HUMAN	transmembrane protein 41A	156						integral to membrane				large_intestine(1)|lung(2)|skin(1)	4	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAAACAATAAGAAAAAAAACAA	0.446													9	184	---	---	---	---					
ZNF395	55893	broad.mit.edu	37	8	28209226	28209228	+	In_Frame_Del	DEL	GCA	GCA	-	rs142343457	byFrequency	TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr8:28209226_28209228delGCA	ENST00000344423.5	-	7	1148_1150	c.1017_1019delTGC	c.(1015-1020)gcc>gc	p.AA339del	ZNF395_ENST00000523202.1_In_Frame_Del_p.AA339del|ZNF395_ENST00000523095.1_In_Frame_Del_p.AA339del	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	339					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGTGCCTgcggcagcagcagcag	0.606													7	120	---	---	---	---					
CPEB3	22849	broad.mit.edu	37	10	93870871	93870872	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr10:93870871_93870872delAG	ENST00000412050.4	-	7	1579_1580	c.1491_1492delCT	c.(1489-1494)ctacfs	p.LY497fs	CPEB3_ENST00000265997.4_Frame_Shift_Del_p.LY511fs	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	511	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				ACACACAGGTAGAGTTTCCCAT	0.465													17	132	---	---	---	---					
SLC22A20	0	broad.mit.edu	37	11	64981480	64981481	+	RNA	INS	-	-	C			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr11:64981480_64981481insC	ENST00000525437.1	+	0	170_171							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						ACGGCCGCTGTCCCCCCCCACC	0.693													2	4	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57589082	57589084	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr12:57589082_57589084delCTC	ENST00000243077.3	+	52	8803_8805	c.8337_8339delCTC	c.(8335-8340)ttc>tt	p.FS2779del		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2779	LDL-receptor class A 17.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCTCCTCCTTCTCCTGCCCTGGC	0.611													58	132	---	---	---	---					
PPL	5493	broad.mit.edu	37	16	4935555	4935557	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr16:4935555_4935557delAGG	ENST00000345988.2	-	22	3188_3190	c.3099_3101delCCT	c.(3097-3102)ctg>ct	p.LL1033del	PPL_ENST00000590782.2_In_Frame_Del_p.LL1031del	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1033					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						ACGCTGCTGCAGGAGGAGCACCT	0.660													24	59	---	---	---	---					
RBBP6	5930	broad.mit.edu	37	16	24582708	24582709	+	Frame_Shift_Del	DEL	AA	AA	-	rs140198744	byFrequency	TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr16:24582708_24582709delAA	ENST00000319715.4	+	18	4753_4754	c.4321_4322delAA	c.(4321-4323)afs	p.K1441fs	RBBP6_ENST00000381039.3_Frame_Shift_Del_p.K601fs|RBBP6_ENST00000348022.2_Frame_Shift_Del_p.K1407fs	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1441	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		AGGAAATTTTAAAAGTCTGTCT	0.391													25	81	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42793215	42793218	+	Frame_Shift_Del	DEL	CAGT	CAGT	-			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr19:42793215_42793218delCAGT	ENST00000572681.2	+	8	3902_3905	c.3834_3837delCAGT	c.(3832-3837)gafs	p.DS1278fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.DS369fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.DS369fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	369	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GAGAAGTAGACAGTCAGGCGCTAC	0.667			"""Mis, F, S"""		oligodendroglioma								12	74	---	---	---	---					
ZNF135	7694	broad.mit.edu	37	19	58578565	58578568	+	Frame_Shift_Del	DEL	GAGA	GAGA	-			TCGA-R8-A6MK-01A-11D-A32B-08	TCGA-R8-A6MK-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	527952da-86f1-497f-9891-a7728bb2699a	a1a9a719-4580-47e5-b1cf-ee58268f754f	g.chr19:58578565_58578568delGAGA	ENST00000506786.1	+	5	1141_1144	c.587_590delGAGA	c.(586-591)ggfs	p.GE196fs	ZNF135_ENST00000359978.6_Frame_Shift_Del_p.GE250fs|ZNF135_ENST00000313434.5_Frame_Shift_Del_p.GE238fs|ZNF135_ENST00000439855.2_Frame_Shift_Del_p.GE238fs|ZNF135_ENST00000511556.1_Frame_Shift_Del_p.GE250fs|ZNF135_ENST00000401053.4_Frame_Shift_Del_p.GE262fs			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	250					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		ACGCACACAGGAGAGAGACCTTAC	0.475													17	86	---	---	---	---					
