Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LINC00969	0	broad.mit.edu	37	3	195398271	195398271	+	RNA	SNP	A	A	G	rs142433257	by1000genomes	TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr3:195398271A>G	ENST00000445430.1	+	0	1088																											GTGTGCAGGCACATGTGCACA	0.542000													4	19					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110932525	110932525	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr4:110932525G>A	ENST00000265171.5	+	24	3983	c.3538G>A	c.(3538-3540)Gag>Aag	p.E1180K	EGF_ENST00000503392.1_Missense_Mutation_p.E1139K|EGF_ENST00000509793.1_Missense_Mutation_p.E1138K	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	1180					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AGGGGGTGTCGAGAAGCCCCA	0.512000													46	58					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1536429	1536429	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr16:1536429G>A	ENST00000440447.2	-	3	574	c.503C>T	c.(502-504)aCg>aTg	p.T168M	PTX4_ENST00000447419.2_Silent_p.Y316Y|PTX4_ENST00000293922.1_Silent_p.Y311Y			Q96A99	PTX4_HUMAN	pentraxin 4, long	0						extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						CCTCGGTGGCGTAGGACAGGA	0.667000													33	30					0	0	1	0	0
TPBG	7162	broad.mit.edu	37	6	83075811	83075811	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr6:83075811G>A	ENST00000369750.3	+	2	1750	c.1133G>A	c.(1132-1134)cGc>cAc	p.R378H	TPBG_ENST00000535040.1_Missense_Mutation_p.R378H|TPBG_ENST00000543496.1_Missense_Mutation_p.R378H			Q13641	TPBG_HUMAN	trophoblast glycoprotein	378					cell adhesion	integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		TATTTGAACCGCAAGGGGATA	0.453000													52	45					0	0	1	0	0
MAP7D3	79649	broad.mit.edu	37	X	135312700	135312700	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chrX:135312700G>A	ENST00000316077.9	-	10	1814	c.1594C>T	c.(1594-1596)Cag>Tag	p.Q532*	MAP7D3_ENST00000370663.5_Nonsense_Mutation_p.Q514*|MAP7D3_ENST00000370661.1_Nonsense_Mutation_p.Q497*	NM_024597.3	NP_078873.2	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	532						cytoplasm|spindle				central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(1)	44	Acute lymphoblastic leukemia(192;0.000127)					TGTGGTGACTGTTTTGAAATA	0.348000													50	63					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345756	33345756	+	Silent	SNP	T	T	C			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr20:33345756T>C	ENST00000374796.2	-	8	3365	c.795A>G	c.(793-795)caA>caG	p.Q265Q	NCOA6_ENST00000359003.2_Silent_p.Q265Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	265	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q265Q(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gttgttgttgttgctgctgct	0.537000													3	44					0	0	1	0	0
TRBV28	0	broad.mit.edu	37	7	142428774	142428774	+	RNA	SNP	A	A	G			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr7:142428774A>G	ENST00000390400.2	+	0	154																											TGTGTCCAGGATATGGACCAT	0.423000													20	18					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													3	36					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212856	26212856	+	Missense_Mutation	SNP	A	A	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chrX:26212856A>T	ENST00000379034.1	+	2	1042	c.893A>T	c.(892-894)aAc>aTc	p.N298I		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	298	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						ATCTTCATGAACGGCAACTGT	0.532000													70	112					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13071766	13071766	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr20:13071766G>T	ENST00000399002.2	+	5	917	c.643G>T	c.(643-645)Gtg>Ttg	p.V215L	SPTLC3_ENST00000378194.4_Missense_Mutation_p.V215L	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	215					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	GGAGGACCTTGTGGCTAAGTT	0.428000													50	53					2.81731e-22	2.97984e-22	1	1	0
PRICKLE2	166336	broad.mit.edu	37	3	64148708	64148708	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr3:64148708G>A	ENST00000295902.6	-	3	827	c.242C>T	c.(241-243)cCg>cTg	p.P81L	PRICKLE2_ENST00000564377.1_Missense_Mutation_p.P137L	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	81	PET.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GTCATGTGGCGGCAGCTGGTG	0.463000													108	105					0	0	1	0	0
USP39	10713	broad.mit.edu	37	2	85852729	85852729	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr2:85852729G>A	ENST00000323701.6	+	5	648	c.638G>A	c.(637-639)cGg>cAg	p.R213Q	USP39_ENST00000409025.1_Missense_Mutation_p.R213Q|USP39_ENST00000409766.3_Missense_Mutation_p.R213Q|USP39_ENST00000459775.1_3'UTR|USP39_ENST00000450066.2_Missense_Mutation_p.R110Q|USP39_ENST00000409470.1_Missense_Mutation_p.R213Q	NM_006590.3	NP_006581.2	Q53GS9	SNUT2_HUMAN	ubiquitin specific peptidase 39	213					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	19						AAATTGTCCCGGGCATATGAT	0.433000													14	91					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139401808	139401808	+	Missense_Mutation	SNP	A	A	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr9:139401808A>T	ENST00000277541.6	-	22	3667	c.3592T>A	c.(3592-3594)Tgc>Agc	p.C1198S		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1198	EGF-like 31; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGTCGAGGCAGGTGCCCCCG	0.672000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			14	2					0	0	1	0	0
IL13RA1	3597	broad.mit.edu	37	X	117895252	117895252	+	Splice_Site	SNP	C	C	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chrX:117895252C>T	ENST00000371666.3	+	6	895	c.828_splice	c.e6+1	p.Y276_splice	IL13RA1_ENST00000371642.1_Silent_p.Y276Y|IL13RA1_ENST00000481868.1_3'UTR	NM_001560.2	NP_001551.1	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1	276						interleukin-13 receptor complex	cytokine receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)	12						ATGTTTTCTACGTAAGGTTTT	0.289000													61	97					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								43	35					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270872	1270872	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr16:1270872G>A	ENST00000348261.5	+	35	7188	c.6940G>A	c.(6940-6942)Gtc>Atc	p.V2314I	CACNA1H_ENST00000565831.1_Missense_Mutation_p.V2308I|CACNA1H_ENST00000358590.4_Missense_Mutation_p.V2308I	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2314					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCCCATGCCCGTCGGTGACCC	0.642000													38	47					0	0	1	0	0
ICOSLG	23308	broad.mit.edu	37	21	45651187	45651187	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr21:45651187G>A	ENST00000407780.3	-	5	965	c.838C>T	c.(838-840)Cga>Tga	p.R280*	ICOSLG_ENST00000400377.3_Nonsense_Mutation_p.R163*|ICOSLG_ENST00000400379.3_Nonsense_Mutation_p.R280*|ICOSLG_ENST00000344330.4_Nonsense_Mutation_p.R280*			O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand	280					B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding			endometrium(2)|lung(1)|stomach(1)|urinary_tract(1)	5				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		TGGAGGCATCGGTCCCTGCAC	0.562000													21	26					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19520806	19520806	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr5:19520806T>C	ENST00000507958.1	-	12	2462	c.1472A>G	c.(1471-1473)gAa>gGa	p.E491G	CDH18_ENST00000502796.1_Missense_Mutation_p.E491G|CDH18_ENST00000382275.1_Missense_Mutation_p.E491G|CDH18_ENST00000506372.1_Missense_Mutation_p.E491G|CDH18_ENST00000511273.1_Missense_Mutation_p.E491G|CDH18_ENST00000274170.4_Missense_Mutation_p.E491G			Q13634	CAD18_HUMAN	cadherin 18, type 2	491	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AATATCATATTCCCTGGCAAG	0.388000													46	49					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9020559	9020559	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr12:9020559C>T	ENST00000299698.7	+	30	4019	c.3839C>T	c.(3838-3840)tCa>tTa	p.S1280L	A2ML1_ENST00000539547.1_Missense_Mutation_p.S789L	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	1124						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						AACATACAGTCAGTTAACAGA	0.488000													33	42					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103063658	103063658	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr2:103063658A>G	ENST00000264260.2	+	10	1790	c.1201A>G	c.(1201-1203)Acg>Gcg	p.T401A	IL18RAP_ENST00000409369.1_Missense_Mutation_p.T259A	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	401					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CAAGGATCAGACGCTTGGGGG	0.557000													56	90					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34825143	34825143	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr6:34825143C>T	ENST00000192788.5	+	12	1640	c.1469C>T	c.(1468-1470)aCa>aTa	p.T490I	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.T490I	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	490										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						AAGCCATCTACACTCCTTTCC	0.438000													19	75					0	0	1	0	0
CELF3	11189	broad.mit.edu	37	1	151677561	151677561	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr1:151677561T>C	ENST00000290583.4	-	12	2147	c.1354A>G	c.(1354-1356)Aaa>Gaa	p.K452E	CELF3_ENST00000470688.1_5'UTR|CELF3_ENST00000392706.3_Missense_Mutation_p.K247E|RP11-98D18.1_ENST00000457548.1_RNA|CELF3_ENST00000290585.4_Missense_Mutation_p.K402E	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	452	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						AGCTGGACTTTGAGGCGCTTC	0.627000													22	29					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70507707	70507707	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr11:70507707C>T	ENST00000338508.4	-	22	1932	c.1933G>A	c.(1933-1935)Gcc>Acc	p.A645T	SHANK2_ENST00000423696.2_Missense_Mutation_p.A265T|SHANK2_ENST00000409530.1_Missense_Mutation_p.A55T|SHANK2_ENST00000409161.1_Missense_Mutation_p.A55T|SHANK2_ENST00000449116.2_Missense_Mutation_p.A56T|SHANK2_ENST00000357171.3_Missense_Mutation_p.A56T|SHANK2_ENST00000449833.2_Missense_Mutation_p.A56T			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	265					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTACCTTTGGCCCCTCGAAGC	0.502000													4	111					0	0	1	0	0
GOPC	57120	broad.mit.edu	37	6	117892068	117892068	+	Silent	SNP	A	A	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr6:117892068A>T	ENST00000535237.1	-	6	1096	c.867T>A	c.(865-867)gtT>gtA	p.V289V	GOPC_ENST00000052569.6_Silent_p.V281V|GOPC_ENST00000368498.2_Silent_p.V289V|GOPC_ENST00000467125.1_5'UTR					golgi-associated PDZ and coiled-coil motif containing										GOPC/ROS1(14)	endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		TAAGGAGGAGAACTTTTCTAA	0.343000			O	ROS1	glioblastoma								11	56					0	0	1	0	0
SYAP1	94056	broad.mit.edu	37	X	16773205	16773205	+	Nonsense_Mutation	SNP	T	T	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chrX:16773205T>A	ENST00000380155.3	+	6	806	c.713T>A	c.(712-714)tTg>tAg	p.L238*		NM_032796.3	NP_116185.2	Q96A49	SYAP1_HUMAN	synapse associated protein 1	238										endometrium(3)|lung(4)|pancreas(1)|prostate(1)|skin(1)	10	Hepatocellular(33;0.0997)					GAGCAAGATTTGCCGCTGGCA	0.517000													32	58					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27688135	27688135	+	Silent	SNP	A	A	G			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr10:27688135A>G	ENST00000438700.3	-	4	1509	c.1392T>C	c.(1390-1392)tcT>tcC	p.S464S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	464	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						TATGCCAGGCAGAAATCATGA	0.368000													24	42					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85942758	85942758	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr16:85942758G>T	ENST00000268638.5	+	3	759	c.337G>T	c.(337-339)Gtt>Ttt	p.V113F	IRF8_ENST00000563180.1_Missense_Mutation_p.V113F	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	113					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				TTACCGAATTGTTCCTGAGGA	0.493000													20	27					9.95505e-16	1.01394e-15	1	1	0
LRRK1	79705	broad.mit.edu	37	15	101589864	101589864	+	Silent	SNP	C	C	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr15:101589864C>T	ENST00000284395.5	+	24	3706	c.3306C>T	c.(3304-3306)gaC>gaT	p.D1102D	LRRK1_ENST00000388948.3_Silent_p.D1105D			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1105					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AATCTTCCGACGTGAACTGGA	0.507000													27	26					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54275530	54275530	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chrX:54275530G>T	ENST00000354646.2	-	17	3689	c.3251C>A	c.(3250-3252)cCa>cAa	p.P1084Q	WNK3_ENST00000375159.2_Missense_Mutation_p.P1084Q|WNK3_ENST00000375169.3_Missense_Mutation_p.P1084Q	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1084					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						AAGGGTAGTTGGTTCAAGGCC	0.433000													33	39					3.80469e-20	3.94827e-20	1	1	0
ISM1	140862	broad.mit.edu	37	20	13260457	13260457	+	Silent	SNP	C	C	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr20:13260457C>T	ENST00000262487.3	+	3	561	c.555C>T	c.(553-555)gaC>gaT	p.D185D	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	185						extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						GTACCTCAGACGACAGCAACT	0.597000													15	33					0	0	1	0	0
PRICKLE1	0	broad.mit.edu	37	12	42860025	42860025	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr12:42860025T>C	ENST00000455697.1	-	6	1031	c.746A>G	c.(745-747)gAg>gGg	p.E249G	PRICKLE1_ENST00000552240.1_Missense_Mutation_p.E249G|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.E249G|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.E249G|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.E249G	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	249	LIM zinc-binding 2.|LIM zinc-binding 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		TTCACAGTACTCCGCATAGAG	0.512000													27	3					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197521413	197521413	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr2:197521413G>A	ENST00000389175.4	+	3	368	c.233G>A	c.(232-234)aGt>aAt	p.S78N	CCDC150_ENST00000272831.7_Intron|CCDC150_ENST00000472405.2_5'UTR|CCDC150_ENST00000423093.2_Intron	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	78										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						AAAGTCATTAGTCCTATCCAA	0.388000													14	18					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													3	70					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609657	84609657	+	Silent	SNP	T	T	C			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr9:84609657T>C	ENST00000344803.2	+	4	4319	c.4272T>C	c.(4270-4272)gaT>gaC	p.D1424D		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		ATGGGATAGATATCACCTGTC	0.517000													13	19					0	0	1	0	0
OR10AD1	121275	broad.mit.edu	37	12	48596567	48596567	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr12:48596567C>T	ENST00000310248.2	-	1	603	c.509G>A	c.(508-510)cGc>cAc	p.R170H		NM_001004134.1	NP_001004134.1	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD, member 1	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|stomach(1)|urinary_tract(1)	9						GTTGTCTCTGCGGAAGGGCTC	0.502000													7	18					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133911126	133911126	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr8:133911126A>G	ENST00000220616.4	+	14	3341	c.3301A>G	c.(3301-3303)Aaa>Gaa	p.K1101E	TG_ENST00000377869.1_Missense_Mutation_p.K1101E	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1101	Thyroglobulin type-1 9.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCATCTCCAAAAGACCTGTT	0.527000													8	14					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78428491	78428491	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr1:78428491delT	ENST00000370767.1	-	14	1395	c.1308delA	c.(1306-1308)atfs	p.I436fs	FUBP1_ENST00000370768.2_Frame_Shift_Del_p.I436fs|FUBP1_ENST00000436586.2_Frame_Shift_Del_p.I457fs			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	436	KH 4.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						GAGCATAGTCTATCTGTTGTG	0.373			"""F, N"""		oligodendroglioma								45	4	---	---	---	---					
ITSN2	50618	broad.mit.edu	37	2	24524110	24524111	+	Splice_Site	INS	-	-	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr2:24524110_24524111insA	ENST00000355123.4	-	11	1439		c.e11-2		ITSN2_ENST00000406921.3_Splice_Site|ITSN2_ENST00000361999.3_Splice_Site	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2						endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTCCTCCTCTAAAAAAATCAA	0.366													25	44	---	---	---	---					
POTEE	445582	broad.mit.edu	37	2	131984464	131984465	+	Frame_Shift_Ins	INS	-	-	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr2:131984464_131984465insA	ENST00000356920.5	+	4	973_974	c.879_880insA	c.(877-882)aaaaaafs	p.KK293fs	PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_Frame_Shift_Ins_p.KK303fs|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	293							ATP binding										TTTTAATCAAGAAAAAAGCGAA	0.342													37	116	---	---	---	---					
CENPE	1062	broad.mit.edu	37	4	104061011	104061013	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr4:104061011_104061013delTCC	ENST00000265148.3	-	38	6226_6228	c.6137_6139delGGA	c.(6136-6141)ata>a	p.RI2046del	CENPE_ENST00000380026.3_Intron	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2046					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GATTCTTTTATCCTCCTTAGCTC	0.360													30	49	---	---	---	---					
RP11-556I14.1	0	broad.mit.edu	37	4	105918246	105918247	+	RNA	INS	-	-	TTT	rs145057012		TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr4:105918246_105918247insTTT	ENST00000506386.1	+	0	71																											tttttttttccttttttttttt	0.317													3	2	---	---	---	---					
RXFP2	122042	broad.mit.edu	37	13	32367130	32367131	+	Frame_Shift_Ins	INS	-	-	A			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr13:32367130_32367131insA	ENST00000298386.2	+	16	1762_1763	c.1691_1692insA	c.(1690-1692)gaafs	p.E564fs	RXFP2_ENST00000380314.1_Frame_Shift_Ins_p.E540fs	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	564						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GATTATTTTGGAAACTTTTATG	0.366													32	50	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102293153	102293155	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr15:102293153_102293155delCTC	ENST00000561463.1	+	0	1199_1201																											AGTTCATCTTCTCAGAGCTGCTG	0.571													2	4	---	---	---	---					
ATXN2L	11273	broad.mit.edu	37	16	28834658	28834659	+	Frame_Shift_Ins	INS	-	-	C			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr16:28834658_28834659insC	ENST00000336783.4	+	1	245_246	c.78_79insC	c.(76-81)cgccccfs	p.RP26fs	ATXN2L_ENST00000325215.6_Frame_Shift_Ins_p.RP26fs|ATXN2L_ENST00000340394.8_Frame_Shift_Ins_p.RP26fs|ATXN2L_ENST00000382686.4_Frame_Shift_Ins_p.RP26fs|ATXN2L_ENST00000395547.2_Frame_Shift_Ins_p.RP26fs|ATXN2L_ENST00000564304.1_Frame_Shift_Ins_p.RP26fs|ATXN2L_ENST00000570200.1_Frame_Shift_Ins_p.RP26fs	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	26	Pro-rich.					membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						TGGCCCGTCGGCCCCCCGGGGG	0.762													2	4	---	---	---	---					
HSD11B1L	374875	broad.mit.edu	37	19	5687962	5687962	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TM-A84G-01A-11D-A36O-08	TCGA-TM-A84G-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31f23d3a-3c7b-4db9-9048-ab061255cb7f	d2e98258-f98c-4259-bcdb-6d332a2f803e	g.chr19:5687962delG	ENST00000577917.1	+	6	982	c.461delG	c.(460-462)cgfs	p.R154fs	HSD11B1L_ENST00000342970.2_3'UTR|HSD11B1L_ENST00000339423.2_3'UTR|HSD11B1L_ENST00000423665.2_Frame_Shift_Del_p.R235fs|RPL36_ENST00000582380.2_Intron|HSD11B1L_ENST00000411793.2_Frame_Shift_Del_p.R101fs|RPL36_ENST00000577222.1_Intron|HSD11B1L_ENST00000581893.1_3'UTR|HSD11B1L_ENST00000581773.1_3'UTR|HSD11B1L_ENST00000301382.4_3'UTR|HSD11B1L_ENST00000581521.1_3'UTR|RPL36_ENST00000579649.1_Intron|HSD11B1L_ENST00000583928.1_3'UTR	NM_001267871.1|NM_198705.2|NM_198708.2	NP_001254800.1|NP_941994.1|NP_941997.1	Q7Z5J1	DHI1L_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1-like	235						extracellular region	binding|oxidoreductase activity										CCTGAGCACCGGGGGGTGCCC	0.682													2	4	---	---	---	---					
