Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GLIPR1L1	256710	broad.mit.edu	37	12	75741494	75741494	+	Silent	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr12:75741494C>T	ENST00000312442.2	+	3	559	c.513C>T	c.(511-513)taC>taT	p.Y171Y	GLIPR1L1_ENST00000378695.4_Silent_p.Y171Y|CAPS2_ENST00000442339.2_Intron	NM_152779.2	NP_689992.1	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	171						extracellular region				endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10						TATGCAACTACGGACCTGCGT	0.358000													4	169					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69795658	69795658	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr4:69795658T>G	ENST00000251566.4	-	6	1487	c.1457A>C	c.(1456-1458)cAc>cCc	p.H486P	UGT2A3_ENST00000420231.2_Missense_Mutation_p.H197P	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	486						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TATAGAGTAGTGCTGGAACCA	0.453000													9	117					0	0	1	0	0
SLC20A1	6574	broad.mit.edu	37	2	113418740	113418740	+	Silent	SNP	A	A	G			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr2:113418740A>G	ENST00000272542.3	+	10	2354	c.1815A>G	c.(1813-1815)gcA>gcG	p.A605A		NM_005415.4	NP_005406.3	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate transporter), member 1	605					phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|skin(1)|urinary_tract(3)	28						TTGAACTGGCATCTGCCCTCA	0.403000													11	79					0	0	1	0	0
ZBTB34	403341	broad.mit.edu	37	9	129642336	129642336	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr9:129642336G>A	ENST00000319119.4	+	2	743	c.658G>A	c.(658-660)Gag>Aag	p.E220K	ZBTB34_ENST00000373452.2_Missense_Mutation_p.E216K	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						GATTCAGATAGAGGGAGACCA	0.577000													8	61					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103216050	103216050	+	Silent	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr7:103216050G>A	ENST00000428762.1	-	29	4407	c.4248C>T	c.(4246-4248)tgC>tgT	p.C1416C	RELN_ENST00000343529.5_Silent_p.C1416C|RELN_ENST00000424685.2_Silent_p.C1416C	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1416	EGF-like 3.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CATGGCCACTGCAGTAACTGG	0.463000													4	96					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212118272	212118272	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:212118272T>A	ENST00000366994.3	-	19	2559	c.2455A>T	c.(2455-2457)Att>Ttt	p.I819F	INTS7_ENST00000366993.3_Missense_Mutation_p.I805F|INTS7_ENST00000440600.2_Missense_Mutation_p.I770F|INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366992.3_Missense_Mutation_p.I799F	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	819					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TGGACAGCAATGGGCTCTGCA	0.507000													10	96					0	0	1	0	0
RRAD	6236	broad.mit.edu	37	16	66956055	66956055	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr16:66956055C>T	ENST00000299759.6	-	5	1101	c.851G>A	c.(850-852)cGc>cAc	p.R284H	RRAD_ENST00000420652.1_Missense_Mutation_p.R284H			P55042	RAD_HUMAN	Ras-related associated with diabetes	284	Calmodulin-binding.				small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		AGCTACGATGCGGCCCAAGAA	0.612000													4	53					0	0	1	0	0
UBA2	10054	broad.mit.edu	37	19	34957913	34957913	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:34957913T>A	ENST00000439527.2	+	16	1945	c.1447T>A	c.(1447-1449)Tcc>Acc	p.S483T	UBA2_ENST00000246548.4_Missense_Mutation_p.S579T|UBA2_ENST00000592791.1_Missense_Mutation_p.S105T			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2	579					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			GCCCTCCACCTCCACAGGTGA	0.463000													3	27					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184093747	184093747	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:184093747C>T	ENST00000204615.7	-	3	284	c.70G>A	c.(70-72)Gct>Act	p.A24T	THPO_ENST00000421442.2_Missense_Mutation_p.A24T|THPO_ENST00000445696.2_Missense_Mutation_p.A24T|EIF2B5_ENST00000444495.1_Intron	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	24					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCAGGAGGAGCCGGGCTGGAC	0.507000													4	74					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457474	110457474	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr8:110457474G>C	ENST00000378402.5	+	38	5480	c.5376G>C	c.(5374-5376)gaG>gaC	p.E1792D		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1792	IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAGCAATAGAGGTTAATGAAA	0.423000										HNSCC(38;0.096)			9	90					0	0	1	0	0
ZNF311	282890	broad.mit.edu	37	6	28963010	28963010	+	Missense_Mutation	SNP	G	G	A	rs75164486	byFrequency	TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr6:28963010G>A	ENST00000377179.3	-	7	2281	c.1769C>T	c.(1768-1770)aCg>aTg	p.T590M	ZNF311_ENST00000483450.1_5'UTR	NM_001010877.2	NP_001010877.2	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	590					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(2)	28						ACGGAAGGACGTGCCACACTC	0.488000													9	110					0	0	1	0	0
OR6C2	341416	broad.mit.edu	37	12	55846632	55846632	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr12:55846632T>C	ENST00000322678.1	+	1	635	c.635T>C	c.(634-636)gTg>gCg	p.V212A	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA	NM_054105.1	NP_473446.1	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C, member 2	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(5)|lung(8)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	23						CTAGTTTGTGTGATTCTGTCC	0.408000													44	178					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44737090	44737090	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr7:44737090G>A	ENST00000222673.5	+	16	2215	c.2173G>A	c.(2173-2175)Gtg>Atg	p.V725M	OGDH_ENST00000447398.1_Missense_Mutation_p.V736M|OGDH_ENST00000439616.2_Missense_Mutation_p.V575M|OGDH_ENST00000449767.1_Missense_Mutation_p.V721M|OGDH_ENST00000543843.1_Missense_Mutation_p.V676M|OGDH_ENST00000444676.1_Missense_Mutation_p.V740M	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	725					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	TGAGTACGGCGTGCTGGGTGA	0.592000													26	64					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109692929	109692929	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr9:109692929G>A	ENST00000277225.5	+	4	6260	c.5971G>A	c.(5971-5973)Gtc>Atc	p.V1991I	ZNF462_ENST00000441147.2_Missense_Mutation_p.V836I|ZNF462_ENST00000457913.1_Missense_Mutation_p.V1991I|ZNF462_ENST00000497489.1_3'UTR			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1991					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCGAAAGCACGTCCAGTATGG	0.498000													4	67					0	0	1	0	0
STC1	6781	broad.mit.edu	37	8	23702537	23702537	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr8:23702537C>A	ENST00000290271.2	-	4	773	c.490G>T	c.(490-492)Gtc>Ttc	p.V164F	STC1_ENST00000524323.1_Missense_Mutation_p.V95F	NM_003155.2	NP_003146.1	P52823	STC1_HUMAN	stanniocalcin 1	164					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity	p.V164L(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		AGGCTTCGGACAAGTCTGTTA	0.522000													7	111					5.18039e-06	5.33055e-06	1	1	0
OR10H1	26539	broad.mit.edu	37	19	15918425	15918425	+	Silent	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:15918425G>A	ENST00000334920.2	-	1	511	c.423C>T	c.(421-423)tgC>tgT	p.C141C		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						CCAGGCAGGCGCAGCCCCGCG	0.647000													10	94					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51824709	51824709	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr6:51824709A>T	ENST00000371117.3	-	36	6142	c.5867T>A	c.(5866-5868)cTg>cAg	p.L1956Q	PKHD1_ENST00000340994.4_Missense_Mutation_p.L1956Q	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1956	G8 1.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GTTAGTGTCCAGCAGAAGCAA	0.458000											OREG0017492	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	183					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86959231	86959231	+	Silent	SNP	A	A	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:86959231A>T	ENST00000234701.3	+	11	1980	c.1629A>T	c.(1627-1629)gtA>gtT	p.V543V	CLCA1_ENST00000394711.1_Silent_p.V543V			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	543					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GTGGCTTTGTAGTGGACAAAA	0.443000													16	23					0	0	1	0	0
NECAP2	55707	broad.mit.edu	37	1	16767279	16767279	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:16767279C>G	ENST00000337132.5	+	1	113	c.23C>G	c.(22-24)tCg>tGg	p.S8W	NECAP2_ENST00000443980.2_Missense_Mutation_p.S8W|NECAP2_ENST00000457722.2_Intron|NECAP2_ENST00000406746.1_Missense_Mutation_p.S8W|NECAP2_ENST00000504551.2_Missense_Mutation_p.S8W|NECAP2_ENST00000486390.1_3'UTR	NM_001145278.1|NM_018090.4	NP_001138750.1|NP_060560.1	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2	8					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		GGGTACGAGTCGGTGCTCTGT	0.652000											OREG0013136	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	33					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468348	56468348	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr11:56468348C>T	ENST00000312153.1	+	1	485	c.485C>T	c.(484-486)aCg>aTg	p.T162M		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						ACCAAGAAAACGTTTTCCTTT	0.448000													5	156					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238050813	238050813	+	Missense_Mutation	SNP	C	C	T	rs141095443	byFrequency	TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:238050813C>T	ENST00000366570.4	-	5	760	c.602G>A	c.(601-603)cGg>cAg	p.R201Q	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	201	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGTCACGTTCCGAGACACAGC	0.532000													21	77					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42718951	42718951	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr5:42718951G>A	ENST00000230882.4	+	10	1532	c.1342G>A	c.(1342-1344)Gtt>Att	p.V448I	GHR_ENST00000537449.1_Missense_Mutation_p.V261I|GHR_ENST00000357703.3_Missense_Mutation_p.V426I	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	448					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GCAGCCCAGTGTTATCCAAGC	0.448000													22	66					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42005362	42005362	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr15:42005362C>T	ENST00000219905.7	+	9	3279	c.3098C>T	c.(3097-3099)aCt>aTt	p.T1033I	MGA_ENST00000570161.1_Missense_Mutation_p.T1033I|MGA_ENST00000545763.1_Missense_Mutation_p.T1033I|MGA_ENST00000389936.4_Missense_Mutation_p.T1033I|MGA_ENST00000566586.1_Missense_Mutation_p.T1033I	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1033						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCCCTCAAAACTAAACCTATC	0.448000													27	122					0	0	1	0	0
CTNND1	1500	broad.mit.edu	37	11	57564168	57564168	+	Silent	SNP	T	T	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr11:57564168T>C	ENST00000524630.1	+	6	1173	c.660T>C	c.(658-660)ggT>ggC	p.G220G	CTNND1_ENST00000526357.1_Silent_p.G166G|CTNND1_ENST00000399039.4_Silent_p.G220G|CTNND1_ENST00000530094.1_Silent_p.G119G|CTNND1_ENST00000428599.2_Silent_p.G220G|CTNND1_ENST00000533667.1_Intron|CTNND1_ENST00000532463.1_Silent_p.G119G|CTNND1_ENST00000526938.1_Silent_p.G220G|CTNND1_ENST00000534579.1_Silent_p.G166G|CTNND1_ENST00000415361.2_Silent_p.G119G|CTNND1_ENST00000361391.6_Silent_p.G220G|CTNND1_ENST00000361332.4_Silent_p.G220G|CTNND1_ENST00000531014.1_Intron|CTNND1_ENST00000532245.1_Silent_p.G119G|CTNND1_ENST00000528232.1_Silent_p.G119G|CTNND1_ENST00000426142.2_Silent_p.G119G|CTNND1_ENST00000361796.4_Silent_p.G220G|CTNND1_ENST00000529986.1_Silent_p.G119G|CTNND1_ENST00000525902.1_Intron|CTNND1_ENST00000360682.6_Silent_p.G220G|CTNND1_ENST00000358694.6_Silent_p.G220G|CTNND1_ENST00000529873.1_Silent_p.G166G|CTNND1_ENST00000399050.4_Silent_p.G220G|CTNND1_ENST00000532787.1_Silent_p.G119G|CTNND1_ENST00000526772.1_Intron|CTNND1_ENST00000529526.1_Silent_p.G166G|CTNND1_ENST00000530748.1_Silent_p.G166G|CTNND1_ENST00000527467.1_Intron|CTNND1_ENST00000532649.1_Silent_p.G166G|CTNND1_ENST00000532844.1_Silent_p.G166G|CTNND1_ENST00000528621.1_Silent_p.G166G|CTNND1_ENST00000529919.1_Silent_p.G220G			O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1	220					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				ATGAAGATGGTTATCCAGGTG	0.562000													33	109					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16038092	16038092	+	Missense_Mutation	SNP	G	G	A	rs145564844	byFrequency	TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:16038092G>A	ENST00000326742.7	-	4	456	c.455C>T	c.(454-456)aCg>aTg	p.T152M	CYP4F11_ENST00000402119.3_Missense_Mutation_p.T152M|CYP4F11_ENST00000248041.7_Missense_Mutation_p.T152M			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	152					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GAAGGCAGGCGTCAACATCCG	0.552000													15	133					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48602392	48602392	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:48602392T>C	ENST00000328333.8	-	117	8749	c.8642A>G	c.(8641-8643)gAt>gGt	p.D2881G	COL7A1_ENST00000470076.1_5'UTR|COL7A1_ENST00000454817.1_Missense_Mutation_p.D2849G	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2881	BPTI/Kunitz inhibitor.|Nonhelical region (NC2).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGAGCCCTCATCCAGTGGCAG	0.612000													4	81					0	0	1	0	0
B9D1	27077	broad.mit.edu	37	17	19251097	19251097	+	Splice_Site	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr17:19251097C>T	ENST00000477478.2	-	4	601	c.268_splice	c.e4+1	p.G90_splice	B9D1_ENST00000268841.6_Splice_Site_p.R114_splice|B9D1_ENST00000575403.1_Splice_Site_p.G90_splice|B9D1_ENST00000461069.2_Splice_Site_p.R114_splice|B9D1_ENST00000395616.3_Splice_Site_p.R114_splice|B9D1_ENST00000395615.1_Splice_Site_p.R114_splice|B9D1_ENST00000261499.4_Splice_Site_p.R114_splice			Q9UPM9	B9D1_HUMAN	B9 protein domain 1	0	B9.				cilium assembly	centrosome|microtubule basal body	protein binding			large_intestine(3)|urinary_tract(1)	4	all_cancers(12;2.04e-05)|all_epithelial(12;0.000806)|Hepatocellular(7;0.00345)|Breast(13;0.143)					GAGGACCTACCGGCCAGGTGA	0.587000													8	32					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								45	70					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117106023	117106023	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr9:117106023C>G	ENST00000307564.4	-	19	3883	c.3722G>C	c.(3721-3723)tGt>tCt	p.C1241S	AKNA_ENST00000492875.1_5'UTR|AKNA_ENST00000374075.5_Missense_Mutation_p.C1160S|AKNA_ENST00000374079.4_Missense_Mutation_p.C186S|AKNA_ENST00000374088.3_Missense_Mutation_p.C1241S|AKNA_ENST00000223791.3_Missense_Mutation_p.C701S	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GCAGTGGGGACAGGAGACTGT	0.587000													6	57					0	0	1	0	0
MDH1B	130752	broad.mit.edu	37	2	207621661	207621661	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr2:207621661A>G	ENST00000374412.3	-	4	649	c.374T>C	c.(373-375)cTg>cCg	p.L125P	MDH1B_ENST00000392214.2_Missense_Mutation_p.L125P|MDH1B_ENST00000454776.2_Missense_Mutation_p.L125P|MDH1B_ENST00000449792.1_Missense_Mutation_p.L27P	NM_001039845.1	NP_001034934.1	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	125					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(14)|ovary(4)|stomach(1)	34				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		GCAAGTTTTCAGGGCTTCTTC	0.428000													16	89					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62045570	62045570	+	Nonsense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr17:62045570C>T	ENST00000578147.1	-	6	925	c.849G>A	c.(847-849)tgG>tgA	p.W283*	SCN4A_ENST00000435607.1_Nonsense_Mutation_p.W283*			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	283					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	ACGGCGGGGGCCAGCGCACAC	0.547000													6	140					0	0	1	0	0
EIF4A1	1973	broad.mit.edu	37	17	7476160	7476160	+	Translation_Start_Site	SNP	A	A	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr17:7476160A>C	ENST00000293831.8	+	1	17	c.1A>C	c.(1-3)Atg>Ctg	p.M1L	EIF4A1_ENST00000582746.1_Start_Codon_SNP_p.M1L|SENP3-EIF4A1_ENST00000579777.1_RNA|EIF4A1_ENST00000577269.1_Start_Codon_SNP_p.M1L|EIF4A1_ENST00000380512.5_5'UTR	NM_001416.3	NP_001407.1	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A1	1					nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			NS(1)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	22						TCTAAGGATCATGTCTGCGAG	0.627000													29	211					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	47					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104066385	104066385	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr4:104066385T>C	ENST00000265148.3	-	32	4768	c.4679A>G	c.(4678-4680)aAg>aGg	p.K1560R	CENPE_ENST00000380026.3_Missense_Mutation_p.K1535R	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1560					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGCTGAATCCTTGGCTTTGCG	0.333000													20	78					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142281276	142281276	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:142281276T>C	ENST00000350721.4	-	4	1089	c.968A>G	c.(967-969)gAa>gGa	p.E323G	ATR_ENST00000383101.3_Missense_Mutation_p.E323G	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	323					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						ACAGAGTTTTTCCAGCAGCAT	0.368000								Other conserved DNA damage response genes					12	114					0	0	1	0	0
FCN3	8547	broad.mit.edu	37	1	27697141	27697141	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:27697141C>T	ENST00000270879.4	-	7	609	c.604G>A	c.(604-606)Ggt>Agt	p.G202S	FCN3_ENST00000354982.2_Missense_Mutation_p.G191S	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	202	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCTACCTCACCGAGGAGGCGG	0.577000													5	100					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74477594	74477594	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr2:74477594G>A	ENST00000394019.2	-	17	1926	c.1529C>T	c.(1528-1530)cCa>cTa	p.P510L	SLC4A5_ENST00000359484.4_Missense_Mutation_p.P446L|SLC4A5_ENST00000357822.5_Missense_Mutation_p.P510L|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000358683.4_Missense_Mutation_p.P446L|SLC4A5_ENST00000346834.4_Missense_Mutation_p.P510L|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.P510L|SLC4A5_ENST00000377632.1_Missense_Mutation_p.P510L|SLC4A5_ENST00000377634.4_Missense_Mutation_p.P510L	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	510						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GAAGTCACTTGGGAACCAGGG	0.527000											OREG0014716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	166					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43415432	43415432	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr6:43415432G>A	ENST00000244533.3	+	16	3991	c.3632G>A	c.(3631-3633)gGc>gAc	p.G1211D	ABCC10_ENST00000372530.4_Missense_Mutation_p.G1239D	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	1239						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTGGGCACCGGCTGGCTGACC	0.632000													6	357					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56440939	56440939	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr17:56440939C>T	ENST00000584437.1	-	3	2353	c.398G>A	c.(397-399)gGa>gAa	p.G133E	BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000407977.2_Missense_Mutation_p.G133E|RNF43_ENST00000581868.1_Missense_Mutation_p.G6E|RNF43_ENST00000500597.2_Missense_Mutation_p.G92E|RNF43_ENST00000577625.1_Missense_Mutation_p.G6E|RNF43_ENST00000583753.1_Missense_Mutation_p.G92E|RNF43_ENST00000577716.1_Missense_Mutation_p.G133E			Q68DV7	RNF43_HUMAN	ring finger protein 43	133						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGCACTGGCTCCTCGCTCACC	0.612000													6	133					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75498581	75498581	+	Silent	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr15:75498581G>A	ENST00000360639.2	+	2	512	c.192G>A	c.(190-192)gcG>gcA	p.A64A	C15orf39_ENST00000394987.4_Silent_p.A64A|C15orf39_ENST00000567617.1_Silent_p.A64A			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	64								p.A64A(1)		autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						AGCAGTTGGCGTCCTGGACCC	0.597000													7	33					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100208068	100208068	+	Silent	SNP	T	T	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr4:100208068T>C	ENST00000209668.2	-	3	311	c.198A>G	c.(196-198)ttA>ttG	p.L66L	RP11-696N14.1_ENST00000500358.2_RNA|ADH1A_ENST00000511656.1_5'UTR	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	66					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CCTCATGGCCTAAAATCACAG	0.498000													4	220					0	0	1	0	0
CYP2D6	1565	broad.mit.edu	37	22	42523567	42523567	+	Missense_Mutation	SNP	T	T	C	rs61736517		TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr22:42523567T>C	ENST00000360608.5	-	7	1169	c.1055A>G	c.(1054-1056)cAc>cGc	p.H352R	NDUFA6-AS1_ENST00000439129.1_RNA|NDUFA6-AS1_ENST00000416037.1_RNA|CYP2D6_ENST00000389970.3_Missense_Mutation_p.H352R|CYP2D6_ENST00000359033.4_Missense_Mutation_p.H301R	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	352							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTAGGGCATGTGAGCCTGGTC	0.592000													6	52					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69403357	69403357	+	Nonsense_Mutation	SNP	T	T	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr4:69403357T>A	ENST00000317746.2	-	6	1621	c.1579A>T	c.(1579-1581)Aag>Tag	p.K527*		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	527					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						TCCCTTTTCTTCTTCTTTCCT	0.408000													34	77					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	307470	307470	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:307470G>A	ENST00000264819.4	-	13	1275	c.1265C>T	c.(1264-1266)cCg>cTg	p.P422L		NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.P422L(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCGAGGACGGGAGTCCATC	0.662000													4	11					0	0	1	0	0
CCDC41	51134	broad.mit.edu	37	12	94805603	94805603	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr12:94805603T>A	ENST00000397809.5	-	4	743	c.194A>T	c.(193-195)aAg>aTg	p.K65M	CCDC41_ENST00000397807.2_Missense_Mutation_p.K32M|CCDC41_ENST00000547575.1_Missense_Mutation_p.K65M|CCDC41_ENST00000339839.5_Missense_Mutation_p.K65M	NM_016122.2	NP_057206.2	Q9Y592	CCD41_HUMAN	coiled-coil domain containing 41	57										breast(1)|central_nervous_system(3)|kidney(3)|large_intestine(8)|lung(8)|prostate(2)|skin(2)	27						ATTTTGTAACTTTACATGTTC	0.318000													13	96					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59798010	59798010	+	Silent	SNP	C	C	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr14:59798010C>A	ENST00000395125.1	+	13	1667	c.1644C>A	c.(1642-1644)ctC>ctA	p.L548L	DAAM1_ENST00000351081.1_Silent_p.L548L|DAAM1_ENST00000360909.3_Silent_p.L548L	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	548	FH1.|Pro-rich.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CTGGATCTCTCCTTCCTCCCC	0.637000													39	43					3.54909e-21	3.76098e-21	1	1	0
CAPZA3	93661	broad.mit.edu	37	12	18891211	18891211	+	Silent	SNP	T	T	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr12:18891211T>A	ENST00000317658.3	+	1	167	c.9T>A	c.(7-9)ctT>ctA	p.L3L		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	3					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				ACATGACACTTAGCGTGCTGA	0.443000													22	89					0	0	1	0	0
TNFSF14	0	broad.mit.edu	37	19	6665024	6665024	+	Silent	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:6665024C>T	ENST00000326176.9	-	5	909	c.528G>A	c.(526-528)ggG>ggA	p.G176G	TNFSF14_ENST00000599359.1_Silent_p.G212G|TNFSF14_ENST00000245912.3_Silent_p.G176G	NM_003807.3|NM_172014.2	NP_003798.2|NP_742011.2	O43557	TNF14_HUMAN	tumor necrosis factor (ligand) superfamily, member 14	212					cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18						CCACCTTCTCCCCAGCCTCCA	0.627000													6	85					0	0	1	0	0
MYO1C	4641	broad.mit.edu	37	17	1384090	1384090	+	Silent	SNP	G	G	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr17:1384090G>T	ENST00000359786.5	-	6	1041	c.717C>A	c.(715-717)atC>atA	p.I239I	MYO1C_ENST00000545534.2_Silent_p.I215I|MYO1C_ENST00000438665.2_Silent_p.I220I|MYO1C_ENST00000575158.1_Silent_p.I204I|MYO1C_ENST00000361007.2_Silent_p.I204I|MYO1C_ENST00000573198.1_5'UTR	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	239	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GCTGGTAGAAGATGTGGAAGT	0.607000													29	79					2.65835e-16	2.77563e-16	1	1	0
TTF1	7270	broad.mit.edu	37	9	135251350	135251350	+	Silent	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr9:135251350G>A	ENST00000334270.2	-	11	2709	c.2670C>T	c.(2668-2670)caC>caT	p.H890H	TTF1_ENST00000461970.1_5'UTR	NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	890					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		aattacaggcgtgagccatgc	0.493000													4	50					0	0	1	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145273385	145273385	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:145273385G>A	ENST00000369340.3	+	4	683	c.239G>A	c.(238-240)gGc>gAc	p.G80D	RP11-458D21.5_ENST00000468030.1_Missense_Mutation_p.G80D|NOTCH2NL_ENST00000362074.6_Missense_Mutation_p.G80D|NOTCH2NL_ENST00000344859.3_Missense_Mutation_p.G80D			Q7Z3S9	NT2NL_HUMAN	notch 2 N-terminal like	80	EGF-like 3.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding	p.G80D(2)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	27						CTGAATGGCGGCACATGCCAT	0.532000													6	386					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1791999	1791999	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:1791999C>G	ENST00000539485.1	-	19	2424	c.2191G>C	c.(2191-2193)Gtg>Ctg	p.V731L	ATP8B3_ENST00000310127.6_Splice_Site|ATP8B3_ENST00000525591.1_Missense_Mutation_p.V684L			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	730					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGTTGTACACCTGTTGCAGG	0.687000													5	7					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195605334	195605334	+	Missense_Mutation	SNP	G	G	A	rs141404332	by1000genomes	TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:195605334G>A	ENST00000333602.6	-	8	1761	c.1144C>T	c.(1144-1146)Cgg>Tgg	p.R382W	TNK2_ENST00000381916.2_Missense_Mutation_p.R445W|TNK2_ENST00000392400.1_Missense_Mutation_p.R382W|TNK2_ENST00000428187.1_Missense_Mutation_p.R414W|TNK2_ENST00000316664.3_Missense_Mutation_p.R382W	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	382	Protein kinase.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.R445W(2)		central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	AGGAAGTCCCGCAGGGCCACA	0.652000													4	117					0	0	1	0	0
DIRC2	84925	broad.mit.edu	37	3	122578991	122578991	+	Silent	SNP	A	A	G			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:122578991A>G	ENST00000261038.5	+	7	1478	c.1080A>G	c.(1078-1080)tcA>tcG	p.S360S		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	360					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		CTACACTGTCATCCACGTGGT	0.378000													41	85					0	0	1	0	0
PDE7A	5150	broad.mit.edu	37	8	66695041	66695041	+	Missense_Mutation	SNP	G	G	A	rs61736484	byFrequency	TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr8:66695041G>A	ENST00000401827.3	-	2	619	c.176C>T	c.(175-177)aCt>aTt	p.T59I	PDE7A_ENST00000379419.4_Missense_Mutation_p.T33I|PDE7A_ENST00000396642.3_Missense_Mutation_p.T59I	NM_001242318.2	NP_001229247.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	59						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GTATAATGCAGTCTGATCAGA	0.289000													5	40					0	0	1	0	0
SLC35A3	23443	broad.mit.edu	37	1	100480866	100480866	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:100480866G>A	ENST00000370155.3	+	6	1035	c.643G>A	c.(643-645)Gga>Aga	p.G215R	SLC35A3_ENST00000370156.3_3'UTR|SLC35A3_ENST00000427993.2_Missense_Mutation_p.G215R|SLC35A3_ENST00000370153.1_Missense_Mutation_p.G257R|SLC35A3_ENST00000465289.1_Intron	NM_012243.1	NP_036375.1	Q9Y2D2	S35A3_HUMAN	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3	215					UDP-N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	sugar:hydrogen symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity			biliary_tract(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	11		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.124)|all cancers(265;0.198)|Lung(183;0.199)		AGGTTTCTTTGGAAGTATATT	0.303000													25	22					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48852241	48852241	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr8:48852241G>A	ENST00000314191.2	-	11	1039	c.983C>T	c.(982-984)gCg>gTg	p.A328V	PRKDC_ENST00000338368.3_Missense_Mutation_p.A328V|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	328					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGCATTTTTCGCCACCATATT	0.294000								Non-homologous end-joining					10	50					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201010635	201010635	+	Silent	SNP	G	G	A			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:201010635G>A	ENST00000362061.3	-	41	5357	c.5131C>T	c.(5131-5133)Ctg>Ttg	p.L1711L	RP11-168O16.2_ENST00000415359.1_RNA|CACNA1S_ENST00000367338.3_Silent_p.L1692L	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1711					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GACTGACCCAGGACCCTGCAG	0.557000													9	31					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238280668	238280668	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr2:238280668C>T	ENST00000295550.4	-	9	4444	c.3992G>A	c.(3991-3993)cGc>cAc	p.R1331H	COL6A3_ENST00000409809.1_Missense_Mutation_p.R1125H|COL6A3_ENST00000392003.2_Missense_Mutation_p.R924H|COL6A3_ENST00000353578.4_Missense_Mutation_p.R1125H|COL6A3_ENST00000347401.3_Missense_Mutation_p.R1130H|COL6A3_ENST00000346358.4_Missense_Mutation_p.R1131H|COL6A3_ENST00000392004.3_Missense_Mutation_p.R1125H|COL6A3_ENST00000472056.1_Missense_Mutation_p.R724H	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1331	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTCTTCAATGCGGCTCCCCAG	0.632000													11	46					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78426109	78426111	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:78426109_78426111delAGG	ENST00000370767.1	-	15	1501_1503	c.1414_1416delCCT	c.(1414-1416)del	p.P472del	FUBP1_ENST00000370768.2_In_Frame_Del_p.P472del|FUBP1_ENST00000436586.2_In_Frame_Del_p.P493del			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	472	Pro-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						CTGGAGGCCCAGGAGGTCCATGG	0.542			"""F, N"""		oligodendroglioma								12	9	---	---	---	---					
FUBP1	8880	broad.mit.edu	37	1	78430386	78430386	+	Frame_Shift_Del	DEL	A	A	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:78430386delA	ENST00000370767.1	-	10	869	c.782delT	c.(781-783)tcfs	p.F261fs	FUBP1_ENST00000370768.2_Frame_Shift_Del_p.F261fs|FUBP1_ENST00000436586.2_Frame_Shift_Del_p.F282fs			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	261					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						AACTTCTCTGAAACCGCCTTG	0.348			"""F, N"""		oligodendroglioma								17	108	---	---	---	---					
NTRK1	4914	broad.mit.edu	37	1	156844179	156844181	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:156844179_156844181delCTT	ENST00000524377.1	+	9	1223_1225	c.1182_1184delCTT	c.(1180-1185)tcc>tc	p.SF394del	NTRK1_ENST00000392302.2_Intron|NTRK1_ENST00000368196.3_Intron|NTRK1_ENST00000358660.3_Intron	NM_002529.3	NP_002520.2	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	394					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CTGCAGTCTCCTTCTCGCCGGTG	0.601			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			12	195	---	---	---	---					
ATP1B1	481	broad.mit.edu	37	1	169100780	169100784	+	Frame_Shift_Del	DEL	AAGTT	AAGTT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:169100780_169100784delAAGTT	ENST00000367816.1	+	7	1428_1432	c.899_903delAAGTT	c.(898-903)gfs	p.EV300fs	ATP1B1_ENST00000367815.3_Frame_Shift_Del_p.EV300fs|ATP1B1_ENST00000367813.3_Frame_Shift_Del_p.EV292fs|ATP1B1_ENST00000499679.3_Frame_Shift_Del_p.EV244fs			P05026	AT1B1_HUMAN	ATPase, Na+/K+ transporting, beta 1 polypeptide	300					ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	14	all_hematologic(923;0.208)					GTAAAAATTGAAGTTAAGAGCTGAT	0.371													11	97	---	---	---	---					
SYT2	127833	broad.mit.edu	37	1	202568405	202568407	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr1:202568405_202568407delTCT	ENST00000367267.1	-	8	1184_1186	c.992_994delAGA	c.(991-996)acc>a	p.KT331del	SYT2_ENST00000367268.4_In_Frame_Del_p.KT331del	NM_001136504.1	NP_001129976.1	Q8N9I0	SYT2_HUMAN	synaptotagmin II	331	C2 2.|Phospholipid binding (By similarity).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	29			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	GGGTTCAGGGTCTTCTTCTTCAC	0.542													10	133	---	---	---	---					
ANKAR	150709	broad.mit.edu	37	2	190541787	190541788	+	Frame_Shift_Del	DEL	AA	AA	-	rs141582205	byFrequency	TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr2:190541787_190541788delAA	ENST00000520309.1	+	2	659_660	c.571_572delAA	c.(571-573)afs	p.K191fs	ANKAR_ENST00000281412.6_5'UTR|ANKAR_ENST00000313581.4_Frame_Shift_Del_p.K191fs|ANKAR_ENST00000438402.2_Frame_Shift_Del_p.K191fs|ANKAR_ENST00000431575.2_Frame_Shift_Del_p.K120fs|ANKAR_ENST00000461516.1_Intron	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	191						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TCAAACAAATAAAGACATTTTT	0.351													15	66	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	RNA	DEL	AGC	AGC	-	rs76272937		TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:12046124_12046126delAGC	ENST00000432424.2	+	0	245_247							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AGCCCCAGCAAGCGCCGAcgccg	0.764													5	8	---	---	---	---					
ARL6	84100	broad.mit.edu	37	3	97486990	97486992	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:97486990_97486992delGAA	ENST00000463745.1	+	2	516_518	c.39_41delGAA	c.(37-42)ctg>ct	p.LK13del	ARL6_ENST00000496713.1_3'UTR|ARL6_ENST00000335979.2_In_Frame_Del_p.LK13del|ARL6_ENST00000394206.1_In_Frame_Del_p.LK13del	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	13					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TGCTTGGCCTGAAGAAGAAGGAG	0.350													10	168	---	---	---	---					
TRMT10C	54931	broad.mit.edu	37	3	101283849	101283851	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:101283849_101283851delAAG	ENST00000309922.6	+	2	378_380	c.224_226delAAG	c.(223-228)caa>c	p.QE75del		NM_017819.2	NP_060289.2			tRNA methyltransferase 10 homolog C (S. cerevisiae)																		TCTAGTGTGCAAGAAGAATGTGT	0.419													24	140	---	---	---	---					
ALG1L2	0	broad.mit.edu	37	3	129814807	129814807	+	RNA	DEL	G	G	-	rs71158106		TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:129814807delG	ENST00000507643.1	+	0	456							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CACTCCCCTCGGGGGGTGTTG	0.607													2	4	---	---	---	---					
RP11-680B3.2	0	broad.mit.edu	37	3	148582959	148582960	+	RNA	INS	-	-	A	rs143382113		TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:148582959_148582960insA	ENST00000488190.1	-	0	304																											TCTCCAGCTGGAAAAAAAAAAC	0.436													4	6	---	---	---	---					
ATP13A5	344905	broad.mit.edu	37	3	193002701	193002702	+	Splice_Site	DEL	AC	AC	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:193002701_193002702delAC	ENST00000342358.4	-	27	3344		c.e27+1		ATP13A5_ENST00000495496.1_Splice_Site	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TTATATACTTACAGTTTGTATA	0.396													11	42	---	---	---	---					
GP5	2814	broad.mit.edu	37	3	194117609	194117609	+	Frame_Shift_Del	DEL	C	C	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:194117609delC	ENST00000401815.1	-	1	1474	c.1403delG	c.(1402-1404)gtfs	p.G468fs	GP5_ENST00000323007.3_Frame_Shift_Del_p.G468fs			P40197	GPV_HUMAN	glycoprotein V (platelet)	468	LRRCT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CTCCGCGTCACCCCCCGGCAG	0.781													7	24	---	---	---	---					
SDHAP1	0	broad.mit.edu	37	3	195711343	195711344	+	RNA	INS	-	-	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr3:195711343_195711344insT	ENST00000427841.1	-	0	585					NR_003264.2																						AAAGACTTCTCTGTGAGCTTTG	0.381													2	4	---	---	---	---					
RIOK2	55781	broad.mit.edu	37	5	96503256	96503258	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr5:96503256_96503258delCTC	ENST00000283109.3	-	8	1378_1380	c.1310_1312delGAG	c.(1309-1314)gtc>g	p.GV437del	CTD-2215E18.1_ENST00000509481.1_Intron|RIOK2_ENST00000508447.1_In_Frame_Del_p.GV437del	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	437	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		CCAGCAGGGACTCCTCCTTGAAC	0.419													7	174	---	---	---	---					
PCDHB13	0	broad.mit.edu	37	5	140595357	140595359	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr5:140595357_140595359delCAA	ENST00000341948.4	+	1	1849_1851	c.1662_1664delCAA	c.(1660-1665)gcc>gc	p.AN554del		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		554	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTGGACGCCAACGACAACTCG	0.719													19	102	---	---	---	---					
GSTA3	2940	broad.mit.edu	37	6	52764820	52764822	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr6:52764820_52764822delAGA	ENST00000211122.3	-	5	389_391	c.324_326delTCT	c.(322-327)ctg>ct	p.LL108del	GSTA3_ENST00000370968.1_In_Frame_Del_p.LL58del	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	108	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	ACATAAGGGCAGAAGAAGGATCA	0.389													9	217	---	---	---	---					
COL12A1	1303	broad.mit.edu	37	6	75875253	75875255	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr6:75875253_75875255delCTC	ENST00000322507.8	-	14	3260_3262	c.2951_2953delGAG	c.(2950-2955)gaa>g	p.GE984del	COL12A1_ENST00000416123.2_In_Frame_Del_p.GE984del|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_In_Frame_Del_p.GE984del	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	984	Fibronectin type-III 6.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GTCAAAGGTTCTCCTTCTCCACT	0.429													34	127	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635420	96635421	+	In_Frame_Ins	INS	-	-	GCC			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr7:96635420_96635421insGCC	ENST00000518156.2	+	1	561_562	c.131_132insGCC	c.(130-132)ccc>cGCCcc	p.43_44insR	DLX6-AS1_ENST00000437541.1_RNA|DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000430027.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6_ENST00000007660.5_Intron|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000430404.2_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					caacagcaacagccgccgccgc	0.698													2	4	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149473220	149473222	+	RNA	DEL	CTT	CTT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr7:149473220_149473222delCTT	ENST00000378016.2	+	0	50							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AAGGGTCCTCCTTCTGCCGCATG	0.675													9	19	---	---	---	---					
EFR3A	23167	broad.mit.edu	37	8	132968029	132968031	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr8:132968029_132968031delCTT	ENST00000254624.5	+	7	878_880	c.653_655delCTT	c.(652-657)cct>c	p.PS218del	EFR3A_ENST00000334503.4_In_Frame_Del_p.PS218del|EFR3A_ENST00000519656.1_In_Frame_Del_p.PS182del	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	218						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			ATAGGCCCTCCTTCTTCTCCTTC	0.355													12	147	---	---	---	---					
RP11-307E17.8	0	broad.mit.edu	37	9	97097144	97097144	+	RNA	DEL	T	T	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr9:97097144delT	ENST00000454869.1	+	0	513					NR_033937.1																						CAAGTTATAAttttttttttt	0.498													3	5	---	---	---	---					
CCDC3	83643	broad.mit.edu	37	10	12940560	12940562	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr10:12940560_12940562delCTT	ENST00000378839.1	-	7	1244_1246	c.292_294delAAG	c.(292-294)del	p.K98del	CCDC3_ENST00000378825.3_In_Frame_Del_p.K223del			Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3	223						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	11		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			ACCTCTTGACCTTCTTCACTCGC	0.631													32	185	---	---	---	---					
CUBN	8029	broad.mit.edu	37	10	16989236	16989237	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr10:16989236_16989237delAA	ENST00000377833.4	-	36	5404_5405	c.5339_5340delTT	c.(5338-5340)tfs	p.F1780fs		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1780	CUB 12.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGATTTACATAAAAGACAGCTG	0.446													17	87	---	---	---	---					
CCDC88B	283234	broad.mit.edu	37	11	64119066	64119068	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr11:64119066_64119068delAGG	ENST00000356786.5	+	18	3121_3123	c.3077_3079delAGG	c.(3076-3081)cag>c	p.QE1026del	CCDC88B_ENST00000359902.2_In_Frame_Del_p.QE178del|CCDC88B_ENST00000301897.4_5'UTR|CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	1026					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CAGCGGGCGCAGGAGCACAGCAG	0.680													3	6	---	---	---	---					
KIAA1551	55196	broad.mit.edu	37	12	32136666	32136668	+	In_Frame_Del	DEL	CTT	CTT	-	rs149470712		TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr12:32136666_32136668delCTT	ENST00000312561.4	+	4	3191_3193	c.2777_2779delCTT	c.(2776-2781)cct>c	p.PS926del	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		CCACAGAAACCTTCTCTACCCAA	0.374													19	67	---	---	---	---					
ATF1	466	broad.mit.edu	37	12	51213443	51213445	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr12:51213443_51213445delAAG	ENST00000262053.3	+	7	719_721	c.697_699delAAG	c.(697-699)del	p.K235del	ATF1_ENST00000539132.1_In_Frame_Del_p.K100del	NM_005171.4	NP_005162.1	P18846	ATF1_HUMAN	activating transcription factor 1	235					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(347)|FUS/ATF1(4)	breast(1)|large_intestine(1)|ovary(2)	4						ATGTCGCAGAAAGAAGAAAGAAT	0.305			T	"""EWSR1, FUS"""	"""malignant melanoma of soft parts , angiomatoid fibrous histiocytoma """								8	101	---	---	---	---					
PSME1	5720	broad.mit.edu	37	14	24606348	24606351	+	Splice_Site	DEL	ACAG	ACAG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr14:24606348_24606351delACAG	ENST00000382708.3	+	3	135		c.e3-1		PSME1_ENST00000206451.6_Splice_Site|PSME1_ENST00000470718.1_Splice_Site|PSME1_ENST00000561435.1_Splice_Site|PSME1_ENST00000559123.1_Splice_Site	NM_176783.1	NP_788955.1	Q06323	PSME1_HUMAN	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(265;0.00831)		CACCTCACACACAGACAGAGAACC	0.574													11	259	---	---	---	---					
YLPM1	56252	broad.mit.edu	37	14	75265962	75265963	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr14:75265962_75265963delCA	ENST00000325680.7	+	5	4086_4087	c.3962_3963delCA	c.(3961-3963)tfs	p.S1321fs	YLPM1_ENST00000238571.3_Frame_Shift_Del_p.S1126fs|YLPM1_ENST00000552421.1_Intron	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GAACAAGAATCACAGTTTCGTG	0.446													8	76	---	---	---	---					
RTF1	23168	broad.mit.edu	37	15	41749919	41749920	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr15:41749919_41749920delAG	ENST00000389629.4	+	4	519_520	c.507_508delAG	c.(505-510)tcacfs	p.SD169fs		NM_015138.4	NP_055953.3	Q92541	RTF1_HUMAN	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	169	Ser-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		GTTCAGATTCAGACTCTTCCTC	0.485													54	157	---	---	---	---					
TPM1	7168	broad.mit.edu	37	15	63335041	63335043	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr15:63335041_63335043delAAG	ENST00000357980.4	+	1	92_94	c.13_15delAAG	c.(13-15)del	p.K7del	TPM1_ENST00000288398.6_In_Frame_Del_p.K7del|TPM1_ENST00000267996.7_In_Frame_Del_p.K7del|TPM1_ENST00000559556.1_In_Frame_Del_p.K7del|TPM1_ENST00000559397.1_In_Frame_Del_p.K7del|TPM1_ENST00000560445.1_In_Frame_Del_p.K7del|TPM1_ENST00000403994.3_In_Frame_Del_p.K7del|TPM1_ENST00000358278.3_In_Frame_Del_p.K7del			P09493	TPM1_HUMAN	tropomyosin 1 (alpha)	7					cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle			endometrium(1)|large_intestine(1)|lung(2)	4						GGACGCCATCAAGAAGAAGATGC	0.690													7	35	---	---	---	---					
ADCY9	115	broad.mit.edu	37	16	4164385	4164387	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr16:4164385_4164387delCTC	ENST00000294016.3	-	2	1595_1597	c.1057_1059delGAG	c.(1057-1059)del	p.E353del		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	353					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						AATTCTCACTCTCCTCATCTCCC	0.478													44	128	---	---	---	---					
TXNDC11	51061	broad.mit.edu	37	16	11773509	11773512	+	Frame_Shift_Del	DEL	TCTC	TCTC	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr16:11773509_11773512delTCTC	ENST00000356957.3	-	13	2604_2607	c.2497_2500delGAGA	c.(2497-2502)tcfs	p.EI833fs	TXNDC11_ENST00000283033.5_Frame_Shift_Del_p.EI806fs|TXNDC11_ENST00000570917.1_5'UTR			Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	833					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						AGTTTCTGGATCTCTCTCTCCAAG	0.588													16	77	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578275	7578277	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr17:7578275_7578277delGAG	ENST00000420246.2	-	6	704_706	c.572_574delCTC	c.(571-576)cag>c	p.PQ191del	TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_In_Frame_Del_p.PQ191del|TP53_ENST00000455263.2_In_Frame_Del_p.PQ191del|TP53_ENST00000445888.2_In_Frame_Del_p.PQ191del|TP53_ENST00000269305.4_In_Frame_Del_p.PQ191del|TP53_ENST00000413465.2_In_Frame_Del_p.PQ191del	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	191	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(83)|p.0?(8)|p.P191del(7)|p.Q99*(6)|p.?(6)|p.Q60*(6)|p.P191delP(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.P191L(2)|p.P191R(2)|p.G187fs*16(2)|p.P59delP(2)|p.P98delP(2)|p.P191fs*56(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P191H(1)|p.P191P(1)|p.P191_Q192delPQ(1)|p.D186_P191delDGLAPP(1)|p.Q192K(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCCAG	0.557		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	60	---	---	---	---					
CTD-2532D12.4	0	broad.mit.edu	37	17	71739904	71739904	+	RNA	DEL	T	T	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr17:71739904delT	ENST00000583854.1	+	0	166																											ctttccctcctccccttcctc	0.532													2	4	---	---	---	---					
CEP192	55125	broad.mit.edu	37	18	13095576	13095578	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr18:13095576_13095578delCTC	ENST00000506447.1	+	35	6409_6411	c.6329_6331delCTC	c.(6328-6333)tct>t	p.SP2110del	CEP192_ENST00000325971.8_In_Frame_Del_p.SP1514del|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000430049.2_In_Frame_Del_p.SP1635del	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1705										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CCTCAGGGTTCTCCTCTTCTCTC	0.512													36	182	---	---	---	---					
AP3D1	8943	broad.mit.edu	37	19	2111786	2111788	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:2111786_2111788delCTT	ENST00000355272.6	-	25	3033_3035	c.2827_2829delAAG	c.(2827-2829)del	p.K943del	AP3D1_ENST00000356926.4_In_Frame_Del_p.K840del|AP3D1_ENST00000350812.6_In_Frame_Del_p.K712del|AP3D1_ENST00000345016.5_In_Frame_Del_p.K881del	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	883					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		tccgctcctccttctccttcctg	0.616													12	24	---	---	---	---					
CTC-260E6.6	0	broad.mit.edu	37	19	20262850	20262850	+	RNA	DEL	T	T	-	rs142097873		TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:20262850delT	ENST00000593655.1	-	0	337				CTC-260E6.6_ENST00000586657.1_RNA																							TTCttttttcttttttttttt	0.468													2	4	---	---	---	---					
CTC-513N18.6	0	broad.mit.edu	37	19	20635101	20635102	+	RNA	INS	-	-	T			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:20635101_20635102insT	ENST00000598131.1	+	0	256																											ACAGGTAGGTGTTTTTTTTGCT	0.416													4	9	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42796461	42796462	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:42796461_42796462delTG	ENST00000572681.2	+	14	5813_5814	c.5745_5746delTG	c.(5743-5748)tatgfs	p.YV1915fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.YV1006fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.YV1006fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1006					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.V1007fs*28(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GAATCACCTATGTGCAGTCAGC	0.649			"""Mis, F, S"""		oligodendroglioma								36	48	---	---	---	---					
ZNF468	90333	broad.mit.edu	37	19	53345269	53345272	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr19:53345269_53345272delTCTT	ENST00000595646.1	-	4	395_398	c.275_278delAAGA	c.(274-279)acfs	p.KD92fs	ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000396409.4_Frame_Shift_Del_p.KD39fs|ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Frame_Shift_Del_p.KD39fs			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		GCCATGAATGTCTTTCTCAATTTC	0.436													19	173	---	---	---	---					
NCOA5	57727	broad.mit.edu	37	20	44691371	44691373	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr20:44691371_44691373delGAG	ENST00000290231.6	-	8	1470_1472	c.1306_1308delCTC	c.(1306-1308)del	p.L436del		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				TGAAGAGGCTGAGGATTTTGGCC	0.586													9	202	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													3	5	---	---	---	---					
MKL1	57591	broad.mit.edu	37	22	40807847	40807848	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chr22:40807847_40807848delTG	ENST00000396617.3	-	15	2942_2943	c.2352_2353delCA	c.(2350-2355)gagtfs	p.DS784fs	MKL1_ENST00000355630.3_Frame_Shift_Del_p.T781fs|MKL1_ENST00000402042.1_Frame_Shift_Del_p.T731fs|MKL1_ENST00000407029.1_Frame_Shift_Del_p.T781fs			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	0	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						ACCCACAGACTGTCTTCGGGGA	0.589			T	RBM15	acute megakaryocytic leukemia								10	292	---	---	---	---					
LAMP2	0	broad.mit.edu	37	X	119580172	119580173	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chrX:119580172_119580173delAA	ENST00000371335.4	-	6	987_988	c.851_852delTT	c.(850-852)tfs	p.F284fs	LAMP2_ENST00000434600.2_Frame_Shift_Del_p.F284fs|LAMP2_ENST00000200639.4_Frame_Shift_Del_p.F284fs|LAMP2_ENST00000538785.1_Frame_Shift_Del_p.F173fs|LAMP2_ENST00000540603.1_Frame_Shift_Del_p.F237fs	NM_013995.2	NP_054701.1	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2	284	Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				endometrium(4)|large_intestine(2)|lung(5)|ovary(2)|urinary_tract(2)	15						CAGCAAAGACAAAGTCTAGATA	0.411													19	103	---	---	---	---					
ACTRT1	139741	broad.mit.edu	37	X	127185177	127185180	+	Frame_Shift_Del	DEL	ATCT	ATCT	-			TCGA-S9-A7QZ-01A-12D-A34J-08	TCGA-S9-A7QZ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	14fee64e-4ac6-4be2-843b-3c7276b0e851	fa940bbf-110e-4dae-a44b-d6ddabf2c0d8	g.chrX:127185177_127185180delATCT	ENST00000371124.3	-	1	1202_1205	c.1006_1009delAGAT	c.(1006-1011)gcfs	p.RC336fs		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	336						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						GCAGAGAAGCATCTATCAGGAGAA	0.520													27	44	---	---	---	---					
