Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PROKR1	10887	broad.mit.edu	37	2	68873329	68873329	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr2:68873329C>T	ENST00000303786.3	+	2	796	c.376C>T	c.(376-378)Cgc>Tgc	p.R126C	PROKR1_ENST00000394342.2_Missense_Mutation_p.R126C			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	126						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CTATGTGGTGCGCCAGCTCTC	0.592000													21	272					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406642	55406642	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:55406642C>T	ENST00000314612.2	+	1	809	c.809C>T	c.(808-810)gCc>gTc	p.A270V		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						AAAGTGTTTGCCCTTTTTTAT	0.403000													18	228					0	0	1	0	0
MFHAS1	9258	broad.mit.edu	37	8	8750064	8750064	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr8:8750064G>A	ENST00000276282.6	-	1	1091	c.505C>T	c.(505-507)Cgg>Tgg	p.R169W		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	169										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TGCGCCAGCCGGTTAAAGCTG	0.677000													6	24					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57528833	57528833	+	Silent	SNP	T	T	C			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr7:57528833T>C	ENST00000420713.1	+	4	778	c.666T>C	c.(664-666)ttT>ttC	p.F222F		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						GCAAATCCTTTAACTGCTCTT	0.398000													8	38					0	0	1	0	0
PARVG	64098	broad.mit.edu	37	22	44583736	44583736	+	Silent	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr22:44583736G>A	ENST00000422871.1	+	5	649	c.225G>A	c.(223-225)ggG>ggA	p.G75G	PARVG_ENST00000444313.2_Silent_p.G75G|PARVG_ENST00000415224.1_Silent_p.G75G	NM_001137605.1	NP_001131077.1	Q9HBI0	PARVG_HUMAN	parvin, gamma	75	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)	17		Ovarian(80;0.024)|all_neural(38;0.0299)				TGTTCGACGGGCTCATCCTAC	0.627000													8	102					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105609285	105609285	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr14:105609285G>A	ENST00000331782.3	-	26	3867	c.3464C>T	c.(3463-3465)aCg>aTg	p.T1155M	JAG2_ENST00000347004.2_Missense_Mutation_p.T1117M	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	1155					auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		cggcggcggcgTGAAGTTCTT	0.721000													35	39					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24372900	24372900	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr16:24372900G>T	ENST00000005284.3	+	4	1866	c.664G>T	c.(664-666)Gcc>Tcc	p.A222S		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	222					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		ATCTACTTTTGCCCGCCTCCC	0.532000													5	173					0.000602214	0.000618273	1	1	0
SEL1L3	23231	broad.mit.edu	37	4	25849364	25849364	+	Translation_Start_Site	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr4:25849364G>A	ENST00000502949.1	-	0	226				SEL1L3_ENST00000399878.3_Silent_p.N95N|SEL1L3_ENST00000513364.1_Intron|SEL1L3_ENST00000264868.5_Silent_p.N60N			Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)							integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						CTTCAGAAACGTTGCGAACGT	0.433000													6	169					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31474146	31474146	+	Silent	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr6:31474146G>A	ENST00000252229.6	+	3	631	c.552G>A	c.(550-552)caG>caA	p.Q184Q	MICB_ENST00000538442.1_Silent_p.Q152Q|MICB_ENST00000399150.3_Silent_p.Q141Q	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	184					antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						GCGCTATGCAGGCAGACTGCC	0.542000													46	59					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													5	196					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158900996	158900996	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr6:158900996C>T	ENST00000367097.3	+	7	2597	c.1240C>T	c.(1240-1242)Ccc>Tcc	p.P414S	TULP4_ENST00000367094.2_Missense_Mutation_p.P414S	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	414	SOCS box.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TGCCTTCATCCCCACCATCAA	0.637000													38	63					0	0	1	0	0
DPPA5	340168	broad.mit.edu	37	6	74063933	74063933	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr6:74063933C>T	ENST00000370370.3	-	1	85	c.16G>A	c.(16-18)Gca>Aca	p.A6T		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	6					multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						TGTCTACGTGCCGGGAGAGTT	0.577000													42	52					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202626336	202626336	+	Silent	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr2:202626336G>A	ENST00000264276.6	-	4	753	c.381C>T	c.(379-381)aaC>aaT	p.N127N	ALS2_ENST00000467448.1_Silent_p.N127N|ALS2_ENST00000496244.1_5'UTR	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	127					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CATACTGCTGGTTGGCTACTG	0.527000													59	88					0	0	1	0	0
CIR1	9541	broad.mit.edu	37	2	175216364	175216364	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr2:175216364C>T	ENST00000342016.3	-	8	666	c.574G>A	c.(574-576)Gca>Aca	p.A192T	CIR1_ENST00000362053.5_Missense_Mutation_p.R201H	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	192					mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						GGATCATTTGCGGTCAAGTTT	0.403000													4	247					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36976456	36976456	+	Nonsense_Mutation	SNP	G	G	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr5:36976456G>T	ENST00000282516.8	+	9	1946	c.1447G>T	c.(1447-1449)Gaa>Taa	p.E483*	NIPBL_ENST00000448238.2_Nonsense_Mutation_p.E483*|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	483					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AATAGAGAGAGAATCAGCTAT	0.363000													17	165					1.33834e-09	1.39259e-09	1	1	0
MRPS31	10240	broad.mit.edu	37	13	41303682	41303682	+	Silent	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr13:41303682C>T	ENST00000323563.6	-	7	1050	c.1014G>A	c.(1012-1014)ctG>ctA	p.L338L	MRPS31_ENST00000498078.1_5'UTR	NM_005830.3	NP_005821.2	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31	338						mitochondrion|ribosome	protein domain specific binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)		GAAAGCTCTCCAGGTGTTTCT	0.363000													19	112					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14749298	14749298	+	Missense_Mutation	SNP	T	T	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr5:14749298T>A	ENST00000284268.6	-	6	1135	c.805A>T	c.(805-807)Agt>Tgt	p.S269C	ANKH_ENST00000503939.1_5'UTR|ANKH_ENST00000535119.1_Missense_Mutation_p.S71C	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	269					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						GCTGCAGAACTGCCACCAAGG	0.542000													4	145					0	0	1	0	0
RGS4	5999	broad.mit.edu	37	1	163044271	163044271	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr1:163044271C>T	ENST00000421743.2	+	6	990	c.830C>T	c.(829-831)cCg>cTg	p.P277L	RGS4_ENST00000491263.1_3'UTR|RGS4_ENST00000367908.4_3'UTR|RGS4_ENST00000531057.1_Intron|RGS4_ENST00000367906.3_Missense_Mutation_p.P162L|RGS4_ENST00000367909.6_Missense_Mutation_p.P180L|RGS4_ENST00000527809.1_Missense_Mutation_p.P162L	NM_001102445.2|NM_001113380.1	NP_001095915.1|NP_001106851.1	P49798	RGS4_HUMAN	regulator of G-protein signaling 4	180					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity	p.P180Q(1)|p.P277Q(1)		breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|upper_aerodigestive_tract(2)	21						TTGGTCAACCCGTCCAGCTGT	0.517000													41	318					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915066	46915066	+	Silent	SNP	A	A	G			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr19:46915066A>G	ENST00000307522.3	-	1	1775	c.1002T>C	c.(1000-1002)aaT>aaC	p.N334N		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	334						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTTCCCTCTGATTATCTGCAG	0.597000													5	242					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr1:155887393T>G	ENST00000368320.3	-	11	1362	c.1337A>C	c.(1336-1338)cAg>cCg	p.Q446P	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q446P			Q7Z7F0	K0907_HUMAN	KIAA0907	446	Pro-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.567000													9	68					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59603468	59603468	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:59603468G>A	ENST00000541311.1	-	7	1045	c.811C>T	c.(811-813)Cca>Tca	p.P271S	GIF_ENST00000257248.2_Missense_Mutation_p.P296S			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	296					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						GGTAGAGTTGGTTGTACCTCA	0.478000													6	253					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140406741	140406741	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr3:140406741A>G	ENST00000286349.3	+	3	1408	c.1217A>G	c.(1216-1218)cAg>cGg	p.Q406R		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	406						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GTGTCCAGGCAGAAGGAAATT	0.443000													4	135					0	0	1	0	0
OTX1	5013	broad.mit.edu	37	2	63283169	63283169	+	Silent	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr2:63283169G>A	ENST00000282549.2	+	5	1059	c.783G>A	c.(781-783)ccG>ccA	p.P261P	OTX1_ENST00000366671.3_Silent_p.P261P	NM_014562.3	NP_055377.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	261						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					ATCACCACCCGCACCAGCTCA	0.652000													4	249					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153130847	153130847	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chrX:153130847G>A	ENST00000370060.1	-	21	2845	c.2656C>T	c.(2656-2658)Cgg>Tgg	p.R886W	L1CAM_ENST00000370055.1_Missense_Mutation_p.R881W|L1CAM_ENST00000361981.3_Missense_Mutation_p.R881W|L1CAM_ENST00000370057.3_Missense_Mutation_p.R886W|L1CAM_ENST00000361699.4_Missense_Mutation_p.R886W|L1CAM_ENST00000543994.1_Missense_Mutation_p.R888W|L1CAM_ENST00000538883.1_Missense_Mutation_p.R888W	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	886	Fibronectin type-III 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane		p.R886W(1)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTATAGGGCCGCAAGCCACTG	0.612000													4	152					0	0	1	0	0
RP11-368J21.3	0	broad.mit.edu	37	16	22588087	22588087	+	RNA	SNP	G	G	C			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr16:22588087G>C	ENST00000550753.1	+	0	2562					NR_003676.2																						GTGGGACACCGTTCCCTGGAT	0.522000													3	62					0	0	1	0	0
DPY19L2P1	0	broad.mit.edu	37	7	35131480	35131480	+	RNA	SNP	A	A	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr7:35131480A>T	ENST00000436258.1	-	0	1889																											ATCTTCGTAAAGTGGATGATT	0.423000													4	130					0	0	1	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30688804	30688804	+	Missense_Mutation	SNP	G	G	C			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr22:30688804G>C	ENST00000215790.7	-	9	1251	c.1087C>G	c.(1087-1089)Cgc>Ggc	p.R363G	RP1-130H16.18_ENST00000447976.1_Intron|TBC1D10A_ENST00000403362.1_Missense_Mutation_p.R275G|TBC1D10A_ENST00000403477.3_Missense_Mutation_p.R370G	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	363						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity	p.R363S(1)		cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						AGGTGTTCGCGCTCAATCTGG	0.637000													37	55					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								71	111					0	0	1	0	0
KBTBD4	55709	broad.mit.edu	37	11	47597155	47597155	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:47597155G>A	ENST00000533290.1	-	2	1475	c.761C>T	c.(760-762)aCa>aTa	p.T254I	NDUFS3_ENST00000533507.1_Intron|KBTBD4_ENST00000525720.1_Missense_Mutation_p.T278I|KBTBD4_ENST00000526005.1_Missense_Mutation_p.T229I|KBTBD4_ENST00000395288.2_Missense_Mutation_p.T229I|KBTBD4_ENST00000430070.2_Missense_Mutation_p.T245I			Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	229				A -> G (in Ref. 1; BAA91616).						NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	24						CTTCAAGCTTGTCCTGAGTGA	0.403000													5	145					0	0	1	0	0
GLRX	2745	broad.mit.edu	37	5	95158225	95158225	+	Missense_Mutation	SNP	T	T	C	rs150319338		TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr5:95158225T>C	ENST00000379979.4	-	1	193	c.142A>G	c.(142-144)Atc>Gtc	p.I48V	GLRX_ENST00000512469.2_Missense_Mutation_p.I48V|GLRX_ENST00000508780.1_Missense_Mutation_p.I48V|GLRX_ENST00000237858.6_Missense_Mutation_p.I48V|GLRX_ENST00000505427.1_Missense_Mutation_p.I48V	NM_002064.2	NP_002055.1	P35754	GLRX1_HUMAN	glutaredoxin (thioltransferase)	48	Glutaredoxin.				cell redox homeostasis|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|transport	cytosol	electron carrier activity|glutathione disulfide oxidoreductase activity|protein disulfide oxidoreductase activity|protein N-terminus binding			endometrium(3)|large_intestine(1)|lung(1)	5		all_cancers(142;3.38e-06)|all_epithelial(76;5.66e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;2.62e-16)	Glutathione(DB00143)	GTGGCTGTGATATCGACAAAT	0.498000													6	301					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141051740	141051740	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr5:141051740G>A	ENST00000239440.4	-	10	1579	c.1514C>T	c.(1513-1515)gCg>gTg	p.A505V	ARAP3_ENST00000508305.1_Missense_Mutation_p.A427V|ARAP3_ENST00000513878.1_Missense_Mutation_p.A167V	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	505	Arf-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCCACAGTCCGCACACTGCCG	0.612000													5	458					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769656	50769656	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr20:50769656G>A	ENST00000216923.4	-	6	1424	c.1075C>T	c.(1075-1077)Cgc>Tgc	p.R359C	ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.R357C|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000346617.4_Missense_Mutation_p.R305C	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TCGTGGATGCGCAGGGCGGCC	0.597000													4	215					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101068571	101068571	+	Silent	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr9:101068571G>A	ENST00000259455.2	-	15	2520	c.2061C>T	c.(2059-2061)aaC>aaT	p.N687N		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	687					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	ACTTGCTGTCGTTGAGTGCGG	0.547000													24	38					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47315042	47315042	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr14:47315042T>C	ENST00000426342.1	-	16	2768	c.2022A>G	c.(2020-2022)atA>atG	p.I674M	MDGA2_ENST00000439988.2_Missense_Mutation_p.I903M|MDGA2_ENST00000399222.3_Missense_Mutation_p.I105M|MDGA2_ENST00000399232.2_Missense_Mutation_p.I972M|MDGA2_ENST00000357362.3_Missense_Mutation_p.I674M	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	903					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						TGTCACCTTCTATTCCAGGAC	0.363000													19	150					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50988099	50988099	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr22:50988099C>T	ENST00000395676.2	+	1	1638	c.1504C>T	c.(1504-1506)Cgg>Tgg	p.R502W		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	502										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGACCTGCTGCGGGGCGTGGG	0.697000													14	151					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28375699	28375699	+	Silent	SNP	G	G	A	rs61756151	byFrequency	TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr15:28375699G>A	ENST00000261609.7	-	82	12720	c.12612C>T	c.(12610-12612)tgC>tgT	p.C4204C		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4204					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ACTGGGATCCGCATTCCACTT	0.418000													6	492					0	0	1	0	0
NHLRC2	374354	broad.mit.edu	37	10	115639379	115639379	+	Silent	SNP	T	T	C			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr10:115639379T>C	ENST00000369301.3	+	4	1046	c.834T>C	c.(832-834)ttT>ttC	p.F278F		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	278					cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		AATCAACTTTTAATTCTCCAC	0.308000													14	207					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77692035	77692035	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr4:77692035C>T	ENST00000296043.6	+	10	6559	c.5606C>T	c.(5605-5607)gCc>gTc	p.A1869V	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1869	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GGTGAAGATGCCAGTAATGAA	0.517000													4	221					0	0	1	0	0
C11orf84	144097	broad.mit.edu	37	11	63586445	63586445	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:63586445G>A	ENST00000294244.4	+	5	1204	c.905G>A	c.(904-906)gGc>gAc	p.G302D		NM_138471.1	NP_612480.1	Q9BUA3	CK084_HUMAN	chromosome 11 open reading frame 84	302										endometrium(3)|kidney(1)|lung(3)|skin(1)	8						GCAGAAGGAGGCCTTCCCCGG	0.662000													4	111					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40049627	40049627	+	Missense_Mutation	SNP	C	C	G			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr20:40049627C>G	ENST00000373233.3	-	31	5825	c.5648G>C	c.(5647-5649)gGc>gCc	p.G1883A		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1883					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TTCCCCCATGCCTACTGCCAT	0.453000													21	156					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14949183	14949183	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr3:14949183G>A	ENST00000285046.5	+	10	3411	c.3301G>A	c.(3301-3303)Gtc>Atc	p.V1101I	FGD5_ENST00000476851.1_3'UTR|FGD5_ENST00000543601.1_Missense_Mutation_p.V860I	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1101					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TGAGCACAGCGTCCGGGGCCA	0.627000													18	98					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769127	31769127	+	Missense_Mutation	SNP	T	T	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr19:31769127T>A	ENST00000240587.4	-	2	1899	c.1572A>T	c.(1570-1572)aaA>aaT	p.K524N		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	524					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TTTCCAAGGATTTGAGGATAT	0.507000													75	153					0	0	1	0	0
HNRNPKP3	0	broad.mit.edu	37	11	43283724	43283724	+	RNA	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:43283724G>A	ENST00000511537.1	-	0	1211					NR_033868.1																						CTGGTCCTATGTTCCTATAAT	0.388000													7	27					0	0	1	0	0
IGHG2	0	broad.mit.edu	37	14	106110437	106110437	+	RNA	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr14:106110437C>T	ENST00000390545.2	-	0	298																											ACAACATTTGCGCTCTGCAGA	0.607000													4	352					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211648	78211648	+	RNA	SNP	A	A	G			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr15:78211648A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CGCCAGGGATAGGGGCTCAGC	0.522000													4	144					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7845400	7845400	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr6:7845400G>A	ENST00000283147.6	+	2	851	c.692G>A	c.(691-693)cGt>cAt	p.R231H		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	231					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity	p.R231H(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					TTCTCCCCTCGTCAGCGACAC	0.468000													20	187					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34487400	34487400	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr20:34487400G>A	ENST00000374012.3	+	10	1520	c.1391G>A	c.(1390-1392)cGc>cAc	p.R464H	PHF20_ENST00000439301.1_3'UTR|PHF20_ENST00000481202.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					AAATTTTTCCGCAAAGCCAAA	0.428000													4	120					0	0	1	0	0
CPNE3	8895	broad.mit.edu	37	8	87568561	87568561	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr8:87568561C>T	ENST00000521271.1	+	16	1648	c.1486C>T	c.(1486-1488)Cag>Tag	p.Q496*	CPNE3_ENST00000198765.4_Nonsense_Mutation_p.Q496*	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	496	VWFA.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						CAGACAGTTCCAGAATGTGAG	0.502000													13	102					0	0	1	0	0
LIN7C	55327	broad.mit.edu	37	11	27520303	27520303	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:27520303C>T	ENST00000278193.2	-	5	507	c.487G>A	c.(487-489)Gca>Aca	p.A163T	LIN7C_ENST00000524596.1_Missense_Mutation_p.A139T	NM_018362.3	NP_060832.1	Q9NUP9	LIN7C_HUMAN	lin-7 homolog C (C. elegans)	163	PDZ.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction				endometrium(2)|lung(2)|upper_aerodigestive_tract(1)	5						TTTCCTTGTGCGGCTTTCAGC	0.388000													6	213					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119859	38119859	+	Silent	SNP	C	C	T	rs66505048		TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr22:38119859C>T	ENST00000406386.3	+	7	1551	c.1296C>T	c.(1294-1296)tgC>tgT	p.C432C	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	432					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.C432C(6)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAACATCCTGCGCCCAGCGGG	0.582000													4	191					0	0	1	0	0
DHRS4	10901	broad.mit.edu	37	14	24424420	24424420	+	Splice_Site	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr14:24424420C>T	ENST00000313250.5	+	2	508	c.306_splice	c.e2+1	p.T102_splice	DHRS4_ENST00000397073.2_Splice_Site_p.T84_splice|DHRS4_ENST00000559632.1_Splice_Site_p.T102_splice|DHRS4_ENST00000308178.8_Splice_Site_p.T84_splice|DHRS4_ENST00000558581.1_Splice_Site_p.T102_splice|DHRS4_ENST00000558263.1_Splice_Site_p.T102_splice|DHRS4_ENST00000397074.3_Splice_Site_p.T102_splice|DHRS4_ENST00000543741.2_Splice_Site_p.T102_splice|DHRS4_ENST00000397075.3_Splice_Site_p.T102_splice|DHRS4_ENST00000382761.3_Splice_Site_p.T84_splice|DHRS4_ENST00000421831.1_Splice_Site_p.T84_splice	NM_021004.2	NP_066284.2	Q9BTZ2	DHRS4_HUMAN	dehydrogenase/reductase (SDR family) member 4	102				T -> M (in Ref. 1; AAD02292).		mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity	p.T102M(4)		central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	CTGGTGGCCACGGTGAGCTGC	0.652000													4	52					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52538884	52538884	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr3:52538884C>T	ENST00000321725.6	+	12	1445	c.1369C>T	c.(1369-1371)Caa>Taa	p.Q457*		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	457	FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CACCTTTAACCAATTCACGGT	0.622000													45	56					0	0	1	0	0
KHNYN	23351	broad.mit.edu	37	14	24901559	24901559	+	Silent	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr14:24901559G>A	ENST00000251343.5	+	3	1231	c.1092G>A	c.(1090-1092)ccG>ccA	p.P364P	KHNYN_ENST00000556842.1_Silent_p.P364P|KHNYN_ENST00000553935.1_Silent_p.P364P			O15037	KHNYN_HUMAN	KH and NYN domain containing	364								p.P364P(1)		kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(3)	24						CACCTGCACCGGAACCCCCAT	0.697000											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	85					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542654	14542654	+	Silent	SNP	C	C	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr18:14542654C>A	ENST00000358970.5	-	1	491	c.492G>T	c.(490-492)acG>acT	p.T164T	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	164								p.T164T(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TGTTCATGTCCGTGTCCCTGA	0.592000													4	315					0.00909568	0.00921536	1	1	0
NLRC5	84166	broad.mit.edu	37	16	57110788	57110788	+	Silent	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr16:57110788G>A	ENST00000262510.6	+	40	5034	c.4809G>A	c.(4807-4809)agG>agA	p.R1603R	NLRC5_ENST00000308149.7_Silent_p.R1574R|NLRC5_ENST00000539144.1_Silent_p.R1574R|NLRC5_ENST00000436936.1_3'UTR	NM_032206.4	NP_115582.4	Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1603					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				AGGCTCTCAGGGCTGCCACCA	0.552000													46	57					0	0	1	0	0
PCDHA1	0	broad.mit.edu	37	5	140166994	140166994	+	Silent	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr5:140166994C>T	ENST00000504120.2	+	1	1119	c.1119C>T	c.(1117-1119)acC>acT	p.T373T	PCDHA1_ENST00000394633.3_Silent_p.T373T|PCDHA1_ENST00000378133.3_Silent_p.T373T	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCATCACCGTGTCTGACC	0.527000													32	157					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27529418	27529418	+	Missense_Mutation	SNP	A	A	C			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr10:27529418A>C	ENST00000375888.1	-	1	69	c.5T>G	c.(4-6)tTc>tGc	p.F2C	ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000396271.3_Intron|ACBD5_ENST00000375897.3_5'UTR|ACBD5_ENST00000375901.1_Intron|ACBD5_ENST00000375905.4_Intron			Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	2					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						ATGAAACTGGAACATGGAGCG	0.632000													9	13					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6599239	6599239	+	Silent	SNP	G	G	A	rs148018915		TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr17:6599239G>A	ENST00000433363.2	-	7	1094	c.861C>T	c.(859-861)tgC>tgT	p.C287C	SLC13A5_ENST00000573648.1_Silent_p.C287C|SLC13A5_ENST00000293800.6_Silent_p.C270C|SLC13A5_ENST00000381074.4_Silent_p.C244C	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	287						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						TCTCTAGCCCGCAGCCCCAGG	0.547000													4	191					0	0	1	0	0
KDELC2	143888	broad.mit.edu	37	11	108352771	108352771	+	Missense_Mutation	SNP	C	C	G			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:108352771C>G	ENST00000434945.2	-	3	997	c.695G>C	c.(694-696)gGt>gCt	p.G232A	KDELC2_ENST00000323468.5_Missense_Mutation_p.G288A|KDELC2_ENST00000532730.1_Intron|KDELC2_ENST00000375648.1_Missense_Mutation_p.G232A			Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2	288						endoplasmic reticulum lumen				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		ATTTGTAACACCCCGCATGGC	0.438000													40	200					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349878	100349878	+	RNA	SNP	C	C	T			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr7:100349878C>T	ENST00000542585.1	+	0	2298				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane		p.P717L(2)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCAGAAAAACCCACCATCCCC	0.507000													5	240					0	0	1	0	0
SLC3A2	6520	broad.mit.edu	37	11	62623842	62623842	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:62623842G>A	ENST00000377892.1	+	1	325	c.101G>A	c.(100-102)gGg>gAg	p.G34E	SLC3A2_ENST00000377891.2_Missense_Mutation_p.G34E|SLC3A2_ENST00000535296.1_Missense_Mutation_p.G34E|SLC3A2_ENST00000377890.2_Missense_Mutation_p.G34E|SLC3A2_ENST00000377889.2_Missense_Mutation_p.G34E			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	34					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						CTCAGCGCGGGGGACGACTCA	0.607000													5	131					0	0	1	0	0
KAZN	23254	broad.mit.edu	37	1	15382609	15382610	+	Frame_Shift_Ins	INS	-	-	G			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr1:15382609_15382610insG	ENST00000376030.2	+	5	1043_1044	c.749_750insG	c.(748-750)cacfs	p.H250fs	KAZN_ENST00000503743.1_Frame_Shift_Ins_p.H250fs|KAZN_ENST00000400797.3_Frame_Shift_Ins_p.H156fs|KAZN_ENST00000361144.5_Frame_Shift_Ins_p.H244fs|KAZN_ENST00000422387.2_Frame_Shift_Ins_p.H250fs|KAZN_ENST00000400798.2_Frame_Shift_Ins_p.H156fs	NM_201628.2	NP_963922.2	Q674X7	KAZRN_HUMAN	kazrin, periplakin interacting protein	250	Interaction with PPL.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus				central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(1)|prostate(2)	25						TTAGCTACGCTGACCAAGGACG	0.614													23	58	---	---	---	---					
ZBTB18	10472	broad.mit.edu	37	1	244217137	244217138	+	Frame_Shift_Ins	INS	-	-	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr1:244217137_244217138insA	ENST00000358704.4	+	2	210_211	c.61_62insA	c.(61-63)gtgfs	p.V21fs		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		ACATTTGCTACAGTGTCTGAGC	0.505													35	75	---	---	---	---					
RP11-390F4.6	0	broad.mit.edu	37	9	6663836	6663839	+	RNA	DEL	AAAC	AAAC	-			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr9:6663836_6663839delAAAC	ENST00000413145.1	+	0	130																											TCCTATTTGTaaacaaacaaacaa	0.417													2	4	---	---	---	---					
FAM189A2	9413	broad.mit.edu	37	9	72003231	72003231	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr9:72003231delG	ENST00000257515.8	+	10	1434	c.1014delG	c.(1012-1014)gtfs	p.V338fs	FAM189A2_ENST00000377216.3_Frame_Shift_Del_p.V125fs|FAM189A2_ENST00000469179.1_3'UTR|FAM189A2_ENST00000303068.7_Frame_Shift_Del_p.V173fs|FAM189A2_ENST00000455972.1_Frame_Shift_Del_p.V338fs	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	338						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						AGCTGCTGGTGGCGAGGTTCC	0.483													11	172	---	---	---	---					
OR4C5	79346	broad.mit.edu	37	11	48387684	48387684	+	Frame_Shift_Del	DEL	T	T	-	rs67755516		TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr11:48387684delT	ENST00000319813.3	-	1	333	c.334delA	c.(334-336)ctfs	p.T112fs						olfactory receptor, family 4, subfamily C, member 5																		AAGGAAATAGTTTTCTTTTCA	0.433													2	4	---	---	---	---					
RP11-273B20.3	0	broad.mit.edu	37	12	7338794	7338794	+	RNA	DEL	G	G	-	rs34548221		TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr12:7338794delG	ENST00000545794.1	-	0	279				RP11-273B20.3_ENST00000543061.1_RNA																							cctgttgagaggggggactga	0.502													3	3	---	---	---	---					
LINC00511	0	broad.mit.edu	37	17	70623820	70623821	+	RNA	INS	-	-	A			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr17:70623820_70623821insA	ENST00000581549.1	-	0	206					NR_033876.1																						aaaactgcctgaaaaaaaaaga	0.426													2	4	---	---	---	---					
TNFSF9	8744	broad.mit.edu	37	19	6531149	6531151	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chr19:6531149_6531151delGCT	ENST00000245817.3	+	1	140_142	c.102_104delGCT	c.(100-105)ggg>gg	p.GL34del		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	34					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						TGGTCGCGGGgctgctgctgctg	0.768													7	116	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149937526	149937528	+	In_Frame_Del	DEL	GGC	GGC	-	rs7877654	byFrequency	TCGA-TQ-A7RG-01A-11D-A33T-08	TCGA-TQ-A7RG-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7ef8640-7181-4ac4-baa3-549e613bda9c	0403a5cd-541a-466c-a7f4-ee68bfd60a19	g.chrX:149937526_149937528delGGC	ENST00000370377.3	-	11	885_887	c.768_770delGCC	c.(766-771)ccc>cc	p.PP256del	CD99L2_ENST00000355149.3_In_Frame_Del_p.PP184del|CD99L2_ENST00000466436.1_In_Frame_Del_p.PP207del|CD99L2_ENST00000437787.2_In_Frame_Del_p.PP183del|CD99L2_ENST00000346693.4_5'UTR	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	256	Poly-Pro.				cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GGCTGGTTCGGGCGGCGGCGGCG	0.611													7	231	---	---	---	---					
