Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRHDE	29953	broad.mit.edu	37	12	72667201	72667201	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:72667201C>A	ENST00000261180.4	+	1	739	c.643C>A	c.(643-645)Cag>Aag	p.Q215K	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	215					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CCCGCAAACCCAGGTCTTAGT	0.572000													28	34					1.75199e-13	2.56325e-13	0.007291	1	0
OGG1	4968	broad.mit.edu	37	3	9798304	9798304	+	Splice_Site	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:9798304G>A	ENST00000302036.7	+	5	1240	c.898_splice	c.e5+1	p.L299_splice	OGG1_ENST00000349503.5_Intron|OGG1_ENST00000344629.7_Splice_Site_p.L299_splice|OGG1_ENST00000339511.5_Splice_Site_p.L299_splice|OGG1_ENST00000449570.2_Splice_Site_p.L299_splice|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302003.7_Splice_Site_p.L299_splice|OGG1_ENST00000302008.8_Splice_Site_p.L299_splice	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	299					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					ACAAGGAACTGGGTGAGGAAA	0.582000								Base excision repair (BER), DNA glycosylases					27	8					0	0	0.006320	0	0
GTF2H1	2965	broad.mit.edu	37	11	18369136	18369136	+	Splice_Site	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:18369136G>T	ENST00000265963.4	+	8	999	c.837_splice	c.e8-1	p.G280_splice	GTF2H1_ENST00000524753.4_Splice_Site_p.G76_splice|GTF2H1_ENST00000530496.2_5'UTR|GTF2H1_ENST00000534641.1_Splice_Site_p.G164_splice|GTF2H1_ENST00000453096.2_Splice_Site_p.G280_splice	NM_005316.3	NP_005307.1	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1, 62kDa	280					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	20						ttCTCACAGGGCTATGGCATT	0.348000								Nucleotide excision repair (NER)					10	23					7.48243e-07	1.05321e-06	0.006214	1	0
MIOX	55586	broad.mit.edu	37	22	50926457	50926457	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:50926457G>A	ENST00000395732.3	+	4	342	c.320G>A	c.(319-321)cGg>cAg	p.R107Q	MIOX_ENST00000216075.6_Missense_Mutation_p.R107Q|MIOX_ENST00000395733.3_Missense_Mutation_p.R107Q			Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	107					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	13		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAGGGCATCCGGAAGGCCCAC	0.652000													15	46					0	0	0.003163	0	0
OR5W2	390148	broad.mit.edu	37	11	55681486	55681486	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:55681486A>T	ENST00000344514.1	-	1	572	c.573T>A	c.(571-573)gaT>gaA	p.D191E		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGACCTGTGTATCTGAGCGAG	0.383000													10	68					0	0	0.008291	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29906732	29906732	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:29906732C>T	ENST00000308713.5	-	5	1228	c.701G>A	c.(700-702)gGt>gAt	p.G234D	SEZ6L2_ENST00000346932.5_Intron|SEZ6L2_ENST00000562159.1_5'UTR|SEZ6L2_ENST00000537485.1_Missense_Mutation_p.G190D|SEZ6L2_ENST00000350527.3_Missense_Mutation_p.G164D	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	234	CUB 1.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGATCCCCCACCAGCCAGCAC	0.622000													34	50					0	0	0.002836	0	0
KIAA1033	23325	broad.mit.edu	37	12	105556620	105556620	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:105556620A>G	ENST00000332180.5	+	30	3241	c.3154A>G	c.(3154-3156)Atg>Gtg	p.M1052V	KIAA1033_ENST00000547171.1_3'UTR	NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	1052					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						TGGCTTTGCCATGGGTAAGCT	0.308000													4	16					0	0	0.000248	0	0
OR2G6	391211	broad.mit.edu	37	1	248684984	248684984	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:248684984C>G	ENST00000343414.4	+	1	69	c.37C>G	c.(37-39)Ctt>Gtt	p.L13V		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAAGGGATTTCTTCTCCTGGG	0.423000													44	75					0	0	0.003610	0	0
SLC7A10	56301	broad.mit.edu	37	19	33699842	33699842	+	Silent	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:33699842T>G	ENST00000253188.3	-	11	1673	c.1527A>C	c.(1525-1527)ccA>ccC	p.P509P		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	509					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					GCAGGGAGGGTGGGCAGGGGC	0.547000													10	70					0	0	0.001523	0	0
CYP2F1	1572	broad.mit.edu	37	19	41630665	41630665	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:41630665C>T	ENST00000331105.2	+	8	1078	c.1006C>T	c.(1006-1008)Cgg>Tgg	p.R336W		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	336					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						GGGACGCGCGCGGCTGCCGGC	0.677000													10	6					0	0	0.008291	0	0
CATSPER1	117144	broad.mit.edu	37	11	65792826	65792826	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:65792826G>T	ENST00000312106.5	-	1	1162	c.1025C>A	c.(1024-1026)gCt>gAt	p.A342D		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	342					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						ACGAGAAGCAGCAGGGCCGGG	0.587000													30	44					1.30897e-18	1.93415e-18	0.001786	1	0
TNRC6A	27327	broad.mit.edu	37	16	24800634	24800634	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:24800634A>T	ENST00000395799.3	+	6	800	c.671A>T	c.(670-672)aAc>aTc	p.N224I	TNRC6A_ENST00000315183.7_Missense_Mutation_p.N224I	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	224	Ser-rich.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCTAGCACAAACTGTAAGAAT	0.448000													47	62					0	0	0.003610	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205306715	205306715	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:205306715G>A	ENST00000367156.3	-	9	1681	c.865C>T	c.(865-867)Caa>Taa	p.Q289*	KLHDC8A_ENST00000539253.1_Nonsense_Mutation_p.Q289*|KLHDC8A_ENST00000460687.1_Nonsense_Mutation_p.Q155*|KLHDC8A_ENST00000367155.3_Nonsense_Mutation_p.Q289*|KLHDC8A_ENST00000537168.1_Nonsense_Mutation_p.Q176*	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	289								p.Q289E(1)		breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACAGTGGGTTGATTCCCTGAA	0.587000													45	51					0	0	0.002852	0	0
ARAP1	116985	broad.mit.edu	37	11	72415374	72415374	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:72415374G>C	ENST00000359373.5	-	14	2666	c.1815C>G	c.(1813-1815)ttC>ttG	p.F605L	ARAP1_ENST00000393605.3_Missense_Mutation_p.F365L|ARAP1_ENST00000334211.8_Missense_Mutation_p.F360L|ARAP1_ENST00000429686.1_Intron|ARAP1-AS2_ENST00000500163.2_RNA|ARAP1_ENST00000426523.1_Missense_Mutation_p.F360L|ARAP1_ENST00000393609.3_Missense_Mutation_p.F605L|ARAP1_ENST00000455638.2_Missense_Mutation_p.F605L			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	605	Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						CCAGCTGTAAGAAGAGCTGTG	0.667000													11	56					0	0	0.001368	0	0
POLQ	10721	broad.mit.edu	37	3	121202255	121202255	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:121202255T>A	ENST00000264233.5	-	18	6076	c.5948A>T	c.(5947-5949)gAg>gTg	p.E1983V		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1983					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		ATAACTTTGCTCCAAGGAGAT	0.303000								DNA polymerases (catalytic subunits)					27	30					0	0	0.008361	0	0
MRPS9	64965	broad.mit.edu	37	2	105696507	105696507	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:105696507A>T	ENST00000258455.3	+	5	586	c.476A>T	c.(475-477)tAt>tTt	p.Y159F		NM_182640.2	NP_872578.1	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9	159					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						CAGTCATACTATTCATTAATG	0.333000													38	60					0	0	0.008740	0	0
KIAA0100	9703	broad.mit.edu	37	17	26962035	26962035	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:26962035G>T	ENST00000528896.2	-	16	2644	c.2570C>A	c.(2569-2571)gCt>gAt	p.A857D	KIAA0100_ENST00000544884.1_Missense_Mutation_p.A714D|RP11-192H23.7_ENST00000577814.1_RNA|KIAA0100_ENST00000389003.3_Missense_Mutation_p.A714D	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	857						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AGAGGCCCAAGCACGAGTCCC	0.483000													85	106					3.61627e-53	5.56493e-53	0.003610	1	0
MYO18B	84700	broad.mit.edu	37	22	26159338	26159338	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:26159338C>T	ENST00000335473.7	+	3	430	c.180C>T	c.(178-180)gtC>gtT	p.V60V	MYO18B_ENST00000407587.2_Silent_p.V60V|MYO18B_ENST00000536101.1_Silent_p.V60V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	60						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGTTAGCTGTCGCCTCTCCAG	0.512000													13	13					0	0	0.001855	0	0
CDK13	8621	broad.mit.edu	37	7	40027286	40027286	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:40027286C>T	ENST00000181839.4	+	2	1905	c.1300C>T	c.(1300-1302)Cgt>Tgt	p.R434C	CDK13_ENST00000340829.5_Missense_Mutation_p.R434C	NM_003718.4|NM_031267.3	NP_003709.3|NP_112557.2	Q14004	CDK13_HUMAN	cyclin-dependent kinase 13	434					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(2)|prostate(2)|skin(5)|stomach(2)|urinary_tract(1)	49						ATCCAGAAGTCGTCATTCTAG	0.463000													25	33					0	0	0.006320	0	0
ZAN	7455	broad.mit.edu	37	7	100348484	100348484	+	RNA	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:100348484G>A	ENST00000542585.1	+	0	1634				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GAACACCTCCGTCACCGTCCC	0.632000													13	64					0	0	0.002450	0	0
DNAH14	127602	broad.mit.edu	37	1	225142660	225142660	+	Splice_Site	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:225142660G>C	ENST00000430092.1	+	3	292		c.e3-1		DNAH14_ENST00000400952.3_Splice_Site|DNAH14_ENST00000366848.1_Splice_Site|DNAH14_ENST00000498360.1_Splice_Site|DNAH14_ENST00000366849.1_Splice_Site|DNAH14_ENST00000439375.2_Splice_Site|DNAH14_ENST00000366850.3_Splice_Site	NM_001373.1	NP_001364.1	Q0VDD8	DYH14_HUMAN	dynein, axonemal, heavy chain 14						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(2)|lung(2)|skin(2)|stomach(1)	27						TTGTCATTTAGACTTTTAAGA	0.264000													27	61					0	0	0.006320	0	0
ZNF446	55663	broad.mit.edu	37	19	58988810	58988810	+	Silent	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:58988810G>C	ENST00000596341.1	+	2	2445	c.225G>C	c.(223-225)ctG>ctC	p.L75L	ZNF446_ENST00000335841.4_Silent_p.L75L|ZNF446_ENST00000594369.1_Silent_p.L75L			Q9NWS9	ZN446_HUMAN	zinc finger protein 446	75	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGCAGTTCCTGGGCACACTGC	0.662000													28	45					0	0	0.006320	0	0
TECTA	7007	broad.mit.edu	37	11	121000847	121000847	+	Silent	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:121000847T>G	ENST00000392793.1	+	10	3139	c.2868T>G	c.(2866-2868)tcT>tcG	p.S956S	TECTA_ENST00000264037.2_Silent_p.S956S			O75443	TECTA_HUMAN	tectorin alpha	956					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCTGTGACTCTGTGGCCCGGT	0.602000													21	43					0	0	0.001882	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412684	139412684	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:139412684C>T	ENST00000277541.6	-	7	1235	c.1160G>A	c.(1159-1161)tGc>tAc	p.C387Y		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	387	EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTTGGTGTCGCAGTTGGAGCC	0.672000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			9	1					0	0	0.006214	0	0
TFAP2B	7021	broad.mit.edu	37	6	50791426	50791426	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:50791426C>A	ENST00000263046.4	+	3	581	c.415C>A	c.(415-417)Ccc>Acc	p.P139T	TFAP2B_ENST00000489228.1_3'UTR|TFAP2B_ENST00000393655.3_Missense_Mutation_p.P130T			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	130					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					GGCCGCCTTGCCCCAGCTCTC	0.721000													7	5					0.00307968	0.00417655	0.003080	1	0
IMPDH2	3615	broad.mit.edu	37	3	49064207	49064207	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:49064207C>T	ENST00000326739.4	-	7	771	c.732G>A	c.(730-732)ctG>ctA	p.L244L		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	244					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCCCACACAGCAGCTGTTTCT	0.517000													113	40					0	0	0.003610	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													4	44					0	0	0.000248	0	0
TP53	7157	broad.mit.edu	37	17	7578268	7578268	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:7578268A>G	ENST00000420246.2	-	6	713	c.581T>C	c.(580-582)cTt>cCt	p.L194P	TP53_ENST00000269305.4_Missense_Mutation_p.L194P|TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.L194P|TP53_ENST00000413465.2_Missense_Mutation_p.L194P|TP53_ENST00000455263.2_Missense_Mutation_p.L194P|TP53_ENST00000445888.2_Missense_Mutation_p.L194P	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	194	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		L -> F (in sporadic cancers; somatic mutation).|L -> H (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(47)|p.L194P(8)|p.L194H(8)|p.0?(8)|p.?(6)|p.L101R(5)|p.L62R(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.L194fs*15(1)|p.L194fs*14(1)|p.L101H(1)|p.L194fs*52(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.L62H(1)|p.I195fs*52(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTCGGATAAGATGCTGAGG	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	12					0	0	0.007291	0	0
KIAA1432	57589	broad.mit.edu	37	9	5774097	5774097	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:5774097G>A	ENST00000414202.2	+	26	4314	c.4123G>A	c.(4123-4125)Gag>Aag	p.E1375K	KIAA1432_ENST00000418622.3_Missense_Mutation_p.E1296K|KIAA1432_ENST00000449720.2_Missense_Mutation_p.E1259K	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	1375						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCCCCGGGCAGAGGAGAGCAG	0.557000													19	19					0	0	0.008871	0	0
LRP4	4038	broad.mit.edu	37	11	46900527	46900527	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:46900527G>C	ENST00000378623.1	-	22	3309	c.3067C>G	c.(3067-3069)Cca>Gca	p.P1023A		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1023					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		AATCCGCTTGGATTTGGGGAC	0.537000													117	125					0	0	0.003610	0	0
NHLRC3	387921	broad.mit.edu	37	13	39621219	39621219	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr13:39621219G>A	ENST00000379600.3	+	6	1043	c.721G>A	c.(721-723)Gat>Aat	p.D241N	NHLRC3_ENST00000470258.1_Missense_Mutation_p.D44N|NHLRC3_ENST00000379599.2_Missense_Mutation_p.D174N	NM_001012754.2	NP_001012772.1	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3	241						extracellular region				breast(1)|kidney(1)|large_intestine(3)|lung(4)|skin(2)	11		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		CCAAGTATTTGATAAAGACAC	0.363000													53	25					0	0	0.003610	0	0
MYO18B	84700	broad.mit.edu	37	22	26423316	26423316	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:26423316G>C	ENST00000335473.7	+	43	7626	c.7376G>C	c.(7375-7377)gGa>gCa	p.G2459A	MYO18B_ENST00000407587.2_Missense_Mutation_p.G2460A|MYO18B_ENST00000536101.1_Missense_Mutation_p.G2459A	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2459						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TCCTTGGCTGGATCAGCCAAA	0.532000													56	83					0	0	0.003610	0	0
ABCG8	64241	broad.mit.edu	37	2	44079515	44079515	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:44079515T>C	ENST00000272286.2	+	5	674	c.584T>C	c.(583-585)cTg>cCg	p.L195P		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	195	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATCGCGGAGCTGCGGCTTAGG	0.637000													24	31					0	0	0.002299	0	0
LYRM2	57226	broad.mit.edu	37	6	90347471	90347471	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:90347471G>A	ENST00000523377.1	-	2	212	c.176C>T	c.(175-177)gCc>gTc	p.A59V	LYRM2_ENST00000520318.1_Missense_Mutation_p.A59V|LYRM2_ENST00000517396.1_5'UTR|LYRM2_ENST00000520441.1_Missense_Mutation_p.A59V	NM_020466.4	NP_065199.1	Q9NU23	LYRM2_HUMAN	LYR motif containing 2	59										kidney(1)|large_intestine(1)|lung(1)	3		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)		CTCTTCGGTGGCACTTTTGTT	0.363000													5	221					0	0	0.000602	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580775	140580775	+	Silent	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140580775A>C	ENST00000354757.3	+	1	1428	c.1428A>C	c.(1426-1428)acA>acC	p.T476T	PCDHB11_ENST00000536699.1_Silent_p.T111T	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		476	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAGCGCTACAGACAGAGACT	0.617000													41	207					0	0	0.008740	0	0
MED16	10025	broad.mit.edu	37	19	885883	885883	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:885883C>T	ENST00000312090.6	-	5	916	c.766G>A	c.(766-768)Gac>Aac	p.D256N	MED16_ENST00000395808.3_Missense_Mutation_p.D256N|MED16_ENST00000325464.1_Missense_Mutation_p.D256N|MED16_ENST00000606828.1_Intron|MED16_ENST00000589119.1_Missense_Mutation_p.D256N|MED16_ENST00000269814.4_Missense_Mutation_p.D256N			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	256					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTCCGTGTCGATACGGCAC	0.647000													4	66					0	0	0.000248	0	0
DENND1A	57706	broad.mit.edu	37	9	126414381	126414381	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:126414381C>G	ENST00000373624.2	-	9	730	c.529G>C	c.(529-531)Gtg>Ctg	p.V177L	DENND1A_ENST00000373620.3_Missense_Mutation_p.V177L|DENND1A_ENST00000373618.1_Missense_Mutation_p.V145L|DENND1A_ENST00000394219.3_Missense_Mutation_p.V145L|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394215.2_Missense_Mutation_p.V147L	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	177	DENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						TCCACAGCCACAAAATATTCT	0.398000													16	45					0	0	0.004990	0	0
DUOX1	53905	broad.mit.edu	37	15	45434285	45434285	+	Silent	SNP	C	C	T	rs140249290	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:45434285C>T	ENST00000321429.4	+	16	2204	c.1797C>T	c.(1795-1797)atC>atT	p.I599I	DUOX1_ENST00000389037.3_Silent_p.I599I|DUOX1_ENST00000561166.1_Silent_p.I245I	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	599					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GGGTCACCATCGGGACCCTCT	0.557000													7	95					0	0	0.003080	0	0
ARAP3	64411	broad.mit.edu	37	5	141059694	141059694	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:141059694G>A	ENST00000239440.4	-	2	425	c.360C>T	c.(358-360)ctC>ctT	p.L120L	ARAP3_ENST00000508305.1_Silent_p.L42L	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	120	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CTGGTCCCCCGAGGGCTGGGC	0.652000													105	41					0	0	0.003610	0	0
XRN1	54464	broad.mit.edu	37	3	142048418	142048418	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:142048418T>C	ENST00000264951.4	-	37	4376	c.4259A>G	c.(4258-4260)cAt>cGt	p.H1420R	XRN1_ENST00000392981.2_Missense_Mutation_p.H1421R	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1420					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						CTGAACATTATGGTACTCATT	0.383000													26	26					0	0	0.004656	0	0
SLC2A11	66035	broad.mit.edu	37	22	24224830	24224830	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:24224830C>T	ENST00000345044.6	+	7	1138	c.870C>T	c.(868-870)gaC>gaT	p.D290D	SLC2A11_ENST00000398356.2_Silent_p.D297D|SLC2A11_ENST00000316185.8_Silent_p.D293D|SLC2A11_ENST00000467660.1_3'UTR|AP000350.10_ENST00000433835.3_Intron			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	290						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						GCGGGAATGACTCGGTGAGAC	0.687000													4	15					0	0	0.000248	0	0
CROCC	9696	broad.mit.edu	37	1	17275397	17275397	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:17275397C>T	ENST00000375541.5	+	19	2881	c.2812C>T	c.(2812-2814)Ctg>Ttg	p.L938L	CROCC_ENST00000467938.1_Intron	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	938					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCAGGCCCTGCTGCTGGCCAA	0.677000													5	67					0	0	0.003080	0	0
TLR3	7098	broad.mit.edu	37	4	187006008	187006008	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:187006008C>G	ENST00000296795.2	+	5	2800	c.2696C>G	c.(2695-2697)tCc>tGc	p.S899C	TLR3_ENST00000504367.1_Missense_Mutation_p.S622C	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	899					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GCACTTGGATCCAAAAACTCT	0.328000													26	26					0	0	0.004656	0	0
GORAB	92344	broad.mit.edu	37	1	170508524	170508524	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:170508524C>A	ENST00000367763.3	+	2	330	c.310C>A	c.(310-312)Cct>Act	p.P104T	GORAB_ENST00000465717.1_3'UTR|GORAB_ENST00000367762.1_Missense_Mutation_p.P104T	NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	104						Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						TCAAAAACCACCTTTTTCTTC	0.473000													16	43					0.000308642	0.000422427	0.003163	1	0
CMYA5	202333	broad.mit.edu	37	5	79033128	79033128	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:79033128C>G	ENST00000446378.2	+	2	8571	c.8540C>G	c.(8539-8541)aCa>aGa	p.T2847R		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2847						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAAGGCATACAGTTCATACT	0.423000													41	25					0	0	0.002522	0	0
ANKRD36B	57730	broad.mit.edu	37	2	98165918	98165918	+	RNA	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:98165918C>G	ENST00000443455.1	-	0	1551							Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B																		TTTTCTCTGGCTATATTCAAA	0.308000													3	36					0	0	0.000602	0	0
ACIN1	22985	broad.mit.edu	37	14	23547373	23547373	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:23547373T>C	ENST00000262710.1	-	8	2611	c.2284A>G	c.(2284-2286)Att>Gtt	p.I762V	ACIN1_ENST00000555053.1_Missense_Mutation_p.I762V|ACIN1_ENST00000457657.1_Missense_Mutation_p.I722V|ACIN1_ENST00000555352.1_5'UTR|ACIN1_ENST00000605057.1_Missense_Mutation_p.I704V	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	762					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GTGTGATGAATTCTTTCTGAT	0.493000													68	106					0	0	0.003610	0	0
RGMB	285704	broad.mit.edu	37	5	98129212	98129212	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:98129212C>G	ENST00000308234.7	+	5	1594	c.1192C>G	c.(1192-1194)Caa>Gaa	p.Q398E	RGMB_ENST00000513185.1_Missense_Mutation_p.Q357E	NM_001012761.2	NP_001012779.2	Q6NW40	RGMB_HUMAN	repulsive guidance molecule family member b	357					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	10		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		TGCCAACACTCAATGCCATGA	0.587000													9	11					0	0	0.006214	0	0
COL4A4	1286	broad.mit.edu	37	2	227924929	227924929	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:227924929G>T	ENST00000396625.3	-	27	2294	c.2087C>A	c.(2086-2088)gCc>gAc	p.A696D	COL4A4_ENST00000329662.7_Missense_Mutation_p.A696D	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	696	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CAGCCCAGGGGCACCTTGGGG	0.428000													36	88					2.09667e-21	3.16096e-21	0.003755	1	0
TAF1D	79101	broad.mit.edu	37	11	93472441	93472441	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:93472441G>C	ENST00000448108.2	-	2	680	c.30C>G	c.(28-30)gaC>gaG	p.D10E		NM_024116.3	NP_077021.1	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			large_intestine(1)|lung(3)|prostate(1)|skin(2)	7						ATGTCACATGGTCAAGAGAAT	0.308000													14	69					0	0	0.003163	0	0
RELA	5970	broad.mit.edu	37	11	65425831	65425831	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:65425831G>A	ENST00000525693.1	-	8	866	c.804C>T	c.(802-804)gtC>gtT	p.V268V	RELA_ENST00000406246.3_Silent_p.V268V|RELA_ENST00000308639.9_Silent_p.V265V			Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	268	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						GCTGCATGGAGACACGCACAG	0.627000													25	43					0	0	0.003330	0	0
STOX2	56977	broad.mit.edu	37	4	184931650	184931650	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:184931650G>T	ENST00000308497.4	+	3	3094	c.1659G>T	c.(1657-1659)gaG>gaT	p.E553D	STOX2_ENST00000438269.1_Missense_Mutation_p.E553D	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	553					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		GCTATAAAGAGGTGTGTATTC	0.522000													18	15					3.52763e-06	4.89583e-06	0.004990	1	0
PRSS58	136541	broad.mit.edu	37	7	141955074	141955074	+	Silent	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:141955074C>A	ENST00000552471.1	-	3	556	c.237G>T	c.(235-237)ctG>ctT	p.L79L	PRSS58_ENST00000547058.2_Silent_p.L79L			Q8IYP2	PRS58_HUMAN	protease, serine, 58	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						CAATCACTTGCAGATGCTTTT	0.413000													36	16					3.76114e-14	5.52999e-14	0.004289	1	0
BPTF	2186	broad.mit.edu	37	17	65905793	65905793	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:65905793G>A	ENST00000321892.4	+	12	3347	c.3286G>A	c.(3286-3288)Gat>Aat	p.D1096N	BPTF_ENST00000306378.6_Missense_Mutation_p.D970N|BPTF_ENST00000335221.5_Missense_Mutation_p.D1096N|BPTF_ENST00000424123.3_Missense_Mutation_p.D957N			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1096					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTCTGAAAAAGATGAGGTAAA	0.343000													11	43					0	0	0.001368	0	0
CROCCP2	84809	broad.mit.edu	37	1	16956491	16956491	+	RNA	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:16956491C>G	ENST00000412962.1	-	0	294																											gatggggtttcgccatgttgg	0.577000													3	16					0	0	0.004672	0	0
GTF3C4	9329	broad.mit.edu	37	9	135546192	135546192	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:135546192G>A	ENST00000372146.4	+	1	771	c.207G>A	c.(205-207)ccG>ccA	p.P69P	GTF3C4_ENST00000483873.2_Silent_p.P69P	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	69					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCCTGGAACCGCTGGCTTGGT	0.706000													4	4					0	0	0.000602	0	0
LILRB4	11006	broad.mit.edu	37	19	55179342	55179342	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:55179342C>T	ENST00000391736.1	+	14	1534	c.1219C>T	c.(1219-1221)Ccc>Tcc	p.P407S	LILRB4_ENST00000270452.2_Missense_Mutation_p.P407S|LILRB4_ENST00000391733.3_Missense_Mutation_p.P408S|LILRB4_ENST00000430952.2_Missense_Mutation_p.P406S|LILRB4_ENST00000391734.3_Missense_Mutation_p.P354S	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	407						integral to membrane|plasma membrane	antigen binding|receptor activity	p.P407S(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		ATCTGAAGCCCCCCAGGATGT	0.647000													4	98					0	0	0.003080	0	0
TAOK3	51347	broad.mit.edu	37	12	118650751	118650751	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:118650751G>A	ENST00000392533.3	-	11	1277	c.787C>T	c.(787-789)Cag>Tag	p.Q263*	TAOK3_ENST00000419821.2_Nonsense_Mutation_p.Q263*	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	263	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCCTTTCCTGAGGTATTTTC	0.348000													17	12					0	0	0.007413	0	0
FUT5	2527	broad.mit.edu	37	19	5867283	5867283	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:5867283A>G	ENST00000252675.5	-	5	1016	c.454T>C	c.(454-456)Tcc>Ccc	p.S152P	FUT5_ENST00000588525.1_Missense_Mutation_p.S152P			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	152					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						TTGCTGGGGGACTCCATGCTG	0.627000													7	30					0	0	0.003080	0	0
GPRC5B	51704	broad.mit.edu	37	16	19871853	19871853	+	Missense_Mutation	SNP	G	G	A	rs147744945		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:19871853G>A	ENST00000300571.2	-	4	1372	c.1181C>T	c.(1180-1182)cCg>cTg	p.P394L	GPRC5B_ENST00000535671.1_Intron|GPRC5B_ENST00000537135.1_Missense_Mutation_p.P420L|GPRC5B_ENST00000569479.1_Missense_Mutation_p.P394L|GPRC5B_ENST00000569847.1_Missense_Mutation_p.P394L	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B	394										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						GTGACTTGGCGGAGCAGTTGG	0.448000													14	23					0	0	0.002450	0	0
PCF11	51585	broad.mit.edu	37	11	82878338	82878338	+	Silent	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:82878338A>G	ENST00000298281.4	+	6	2441	c.1989A>G	c.(1987-1989)gaA>gaG	p.E663E		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	663					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GCAAAAGAGAATTACTTCAAA	0.313000													12	35					0	0	0.000978	0	0
WWP1	11059	broad.mit.edu	37	8	87414410	87414410	+	Silent	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:87414410A>G	ENST00000517970.1	+	8	1009	c.702A>G	c.(700-702)gcA>gcG	p.A234A	WWP1_ENST00000341922.2_Intron|WWP1_ENST00000349423.2_Intron|WWP1_ENST00000265428.4_Silent_p.A234A	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	234					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						AACCACTCGCATCTGAGCCTG	0.448000													15	27					0	0	0.004990	0	0
TANC1	85461	broad.mit.edu	37	2	160053172	160053172	+	Silent	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:160053172G>T	ENST00000263635.6	+	18	3270	c.3033G>T	c.(3031-3033)cgG>cgT	p.R1011R	TANC1_ENST00000454300.1_Silent_p.R905R	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	1011						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						GTGCCCTACGGGGCCACGGTG	0.622000													25	53					2.24059e-21	3.36089e-21	0.006320	1	0
IGHV2-5	28457	broad.mit.edu	37	14	106494249	106494249	+	RNA	SNP	G	G	T	rs148245067	by1000genomes	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:106494249G>T	ENST00000390597.2	-	0	262																											TCAGAGATGGGCTGTAGCGCT	0.532000													35	74					9.65963e-10	1.39864e-09	0.003271	1	0
TLR3	7098	broad.mit.edu	37	4	187004613	187004613	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:187004613C>T	ENST00000296795.2	+	4	1877	c.1773C>T	c.(1771-1773)atC>atT	p.I591I	TLR3_ENST00000504367.1_Silent_p.I314I	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	591					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TAAAGATCATCGATTTAGGAT	0.388000													30	45					0	0	0.007291	0	0
TTC27	55622	broad.mit.edu	37	2	32927945	32927945	+	Silent	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:32927945A>G	ENST00000317907.4	+	10	1422	c.1191A>G	c.(1189-1191)aaA>aaG	p.K397K		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	397							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						AACTTGAGAAAGGAAGTACTC	0.438000													50	102					0	0	0.003610	0	0
DGCR5	26220	broad.mit.edu	37	22	18979561	18979561	+	RNA	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:18979561G>C	ENST00000438934.1	+	0	2912				DGCR5_ENST00000537283.1_RNA|DGCR5_ENST00000440005.2_RNA																							CAGAGAACCCGCAGGGTTGTT	0.587000													3	19					0	0	0.004672	0	0
INTS7	25896	broad.mit.edu	37	1	212120048	212120048	+	Splice_Site	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:212120048C>T	ENST00000366994.3	-	18	2421		c.e18-1		INTS7_ENST00000440600.2_Splice_Site|INTS7_ENST00000469606.1_Splice_Site|INTS7_ENST00000366992.3_Intron|INTS7_ENST00000366993.3_Splice_Site	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7						snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ATGCTGTGTGCTGGGGGAAAA	0.348000													3	58					0	0	0.000248	0	0
MAMSTR	284358	broad.mit.edu	37	19	49216571	49216571	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:49216571C>G	ENST00000318083.6	-	10	1264	c.1201G>C	c.(1201-1203)Gac>Cac	p.D401H	MAMSTR_ENST00000419611.1_Missense_Mutation_p.D298H|MAMSTR_ENST00000377367.3_Missense_Mutation_p.D233H|MAMSTR_ENST00000594582.1_Missense_Mutation_p.D233H|MAMSTR_ENST00000356751.4_Missense_Mutation_p.D298H			Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing transcriptional regulator	401	Ser-rich.|Transcription activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(1)|ovary(1)	2						CTGCTGGAGTCAGATAAGTCA	0.617000											OREG0025608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	17					0	0	0.001855	0	0
MDN1	23195	broad.mit.edu	37	6	90409446	90409446	+	Splice_Site	SNP	T	T	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:90409446T>A	ENST00000369393.3	-	58	8986	c.8870_splice	c.e58-1	p.R2957_splice	MDN1_ENST00000428876.1_Splice_Site_p.R2957_splice			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2957					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTTGCTGCATCTGTTCCAAA	0.408000													31	38					0	0	0.002836	0	0
CEBPZ	10153	broad.mit.edu	37	2	37455847	37455847	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:37455847T>C	ENST00000234170.5	-	2	634	c.489A>G	c.(487-489)aaA>aaG	p.K163K		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	163					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				AGATGTTCTGTTTATCTTTCT	0.373000													50	70					0	0	0.003610	0	0
ZDHHC11	79844	broad.mit.edu	37	5	837492	837492	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:837492T>C	ENST00000283441.8	-	6	1271	c.888A>G	c.(886-888)aaA>aaG	p.K296K	ZDHHC11_ENST00000424784.2_Silent_p.K296K|ZDHHC11_ENST00000503758.2_5'UTR	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	296						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GGAGAACTCCTTTGTCCATTT	0.478000													9	301					0	0	0.008291	0	0
OR51G1	79324	broad.mit.edu	37	11	4945555	4945555	+	Silent	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:4945555A>C	ENST00000321961.2	-	1	82	c.15T>G	c.(13-15)ctT>ctG	p.L5L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCTGCTATTAAGAAGAATTG	0.438000													31	12					0	0	0.001786	0	0
ZNF91	7644	broad.mit.edu	37	19	23544273	23544273	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544273G>A	ENST00000300619.7	-	4	1713	c.1508C>T	c.(1507-1509)tCa>tTa	p.S503L	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.S471L	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	503						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTAAGGGTTGAGGATTGCCT	0.368000													11	31					0	0	0.008291	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													5	106					0	0	0.001168	0	0
NCOR2	9612	broad.mit.edu	37	12	124821412	124821412	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:124821412G>C	ENST00000356219.3	-	39	6178	c.6023C>G	c.(6022-6024)cCt>cGt	p.P2008R	NCOR2_ENST00000404121.2_Missense_Mutation_p.P1562R|NCOR2_ENST00000397355.1_Missense_Mutation_p.P1992R|NCOR2_ENST00000405201.1_Missense_Mutation_p.P2001R|NCOR2_ENST00000429285.2_Missense_Mutation_p.P1991R|NCOR2_ENST00000404621.1_Missense_Mutation_p.P1991R	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2012					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGCGTGGTGAGGTGCGAGGTT	0.687000													18	16					0	0	0.004990	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000358464.4_Silent_p.G95G|FRG1B_ENST00000439954.2_Silent_p.G100G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													4	75					0	0	0.000602	0	0
CDC25B	994	broad.mit.edu	37	20	3782640	3782640	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:3782640C>G	ENST00000245960.5	+	10	1688	c.991C>G	c.(991-993)Ccc>Gcc	p.P331A	CDC25B_ENST00000344256.6_Missense_Mutation_p.P267A|CDC25B_ENST00000340833.4_Missense_Mutation_p.P290A|CDC25B_ENST00000379598.5_Missense_Mutation_p.P240A|CDC25B_ENST00000439880.2_Missense_Mutation_p.P317A|CDC25B_ENST00000467519.1_3'UTR	NM_004358.3|NM_021872.2|NM_021873.2	NP_004349.1|NP_068658.1|NP_068659.1	P30305	MPIP2_HUMAN	cell division cycle 25B	331					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			NS(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(1)	18						CGTGATCCGGCCCATCCTCAA	0.652000													3	12					0	0	0.004672	0	0
SGMS1-AS1	104355295	broad.mit.edu	37	10	52390636	52390636	+	RNA	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr10:52390636C>G	ENST00000443374.1	+	0	1329																											CAATCAAACTCTTCATCGTCA	0.443000													11	33					0	0	0.008291	0	0
TDRD6	221400	broad.mit.edu	37	6	46658086	46658086	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:46658086A>G	ENST00000544460.1	+	1	2475	c.2221A>G	c.(2221-2223)Aaa>Gaa	p.K741E	TDRD6_ENST00000316081.6_Missense_Mutation_p.K741E	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	741					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TGTGCAGGAAAAAGTGAAAAG	0.393000													10	12					0	0	0.008291	0	0
AC112229.4	0	broad.mit.edu	37	2	111144370	111144370	+	RNA	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:111144370T>C	ENST00000606848.1	-	0	1370																											GGCAGCACCATAGTGGCGGCC	0.622000													2	0					0	0	0.004672	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719966	140719966	+	Silent	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140719966C>A	ENST00000394576.2	+	1	1428	c.1428C>A	c.(1426-1428)gcC>gcA	p.A476A	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGACGGCCCATGACCCCG	0.542000													21	86					4.43304e-23	6.71741e-23	0.006320	1	0
ZFP42	132625	broad.mit.edu	37	4	188924382	188924382	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:188924382C>G	ENST00000326866.4	+	4	829	c.421C>G	c.(421-423)Ctt>Gtt	p.L141V	ZFP42_ENST00000509524.1_Missense_Mutation_p.L141V	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	141					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AGAGAATTCGCTTGAGTATTC	0.418000													50	88					0	0	0.003610	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	78					0	0	0.004672	0	0
PRDM2	7799	broad.mit.edu	37	1	14108768	14108768	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:14108768C>T	ENST00000235372.7	+	8	5334	c.4478C>T	c.(4477-4479)tCa>tTa	p.S1493L	PRDM2_ENST00000343137.4_Missense_Mutation_p.S1292L|PRDM2_ENST00000311066.5_Missense_Mutation_p.S1493L|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.S1292L	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	1493						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GTTTCTCATTCATCTAAGAAA	0.448000													56	161					0	0	0.003610	0	0
MAML3	55534	broad.mit.edu	37	4	140811147	140811147	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:140811147G>A	ENST00000509479.2	-	2	2299	c.1443C>T	c.(1441-1443)ctC>ctT	p.L481L	MAML3_ENST00000398940.1_Silent_p.L20L|MAML3_ENST00000327122.5_Silent_p.L325L	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	481	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					tctgctgcATGAGTTTGGCCC	0.577000													13	24					0	0	0.001855	0	0
DIS3L2	129563	broad.mit.edu	37	2	233075076	233075076	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:233075076G>T	ENST00000325385.7	+	10	1441	c.1165G>T	c.(1165-1167)Gac>Tac	p.D389Y	DIS3L2_ENST00000273009.6_Missense_Mutation_p.D389Y|DIS3L2_ENST00000409307.1_Missense_Mutation_p.D389Y	NM_152383.4	NP_689596.4	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	389							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AACCGCCCGAGACCTCGATGA	0.478000													16	75					6.49762e-13	9.45977e-13	0.006122	1	0
CTU2	348180	broad.mit.edu	37	16	88780121	88780121	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:88780121G>A	ENST00000567949.1	+	9	1162	c.1153G>A	c.(1153-1155)Gag>Aag	p.E385K	CTU2_ENST00000378384.3_Missense_Mutation_p.E227K|CTU2_ENST00000312060.5_Missense_Mutation_p.E314K|CTU2_ENST00000453996.2_Missense_Mutation_p.E314K			Q2VPK5	CTU2_HUMAN	cytosolic thiouridylase subunit 2 homolog (S. pombe)	314					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			NS(1)|breast(1)|endometrium(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11						CACCCTGAAGGAGGTCGCTTT	0.637000													44	106					0	0	0.002852	0	0
AEN	64782	broad.mit.edu	37	15	89173493	89173493	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:89173493G>T	ENST00000332810.3	+	4	1097	c.946G>T	c.(946-948)Gga>Tga	p.G316*	AEN_ENST00000379231.3_Intron	NM_022767.3	NP_073604.3	Q8WTP8	AEN_HUMAN	apoptosis enhancing nuclease	316					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding			NS(1)|kidney(1)|large_intestine(1)|lung(4)	7						CAGCAGAGGAGGAGCCAGGGA	0.647000													8	9					0.00448238	0.00602383	0.004482	1	0
ARID1B	57492	broad.mit.edu	37	6	157522507	157522507	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:157522507C>T	ENST00000346085.5	+	18	4780	c.4779C>T	c.(4777-4779)acC>acT	p.T1593T	ARID1B_ENST00000367148.1_Silent_p.T1633T|ARID1B_ENST00000350026.5_Silent_p.T1580T|ARID1B_ENST00000275248.4_Silent_p.T1575T	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1580	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCCAGGTCACCGGGCCACCAC	0.547000													45	130					0	0	0.002852	0	0
LCOR	84458	broad.mit.edu	37	10	98714920	98714920	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr10:98714920G>C	ENST00000540664.1	+	8	1086	c.543G>C	c.(541-543)caG>caC	p.Q181H	LCOR_ENST00000371103.3_Missense_Mutation_p.Q181H|LCOR_ENST00000498444.1_Intron|LCOR_ENST00000356016.3_Missense_Mutation_p.Q181H|LCOR_ENST00000371097.4_Missense_Mutation_p.Q181H	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CTGGATTACAGAATCATGGAC	0.478000													24	34					0	0	0.002780	0	0
EPHA6	285220	broad.mit.edu	37	3	97202882	97202882	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:97202882A>T	ENST00000389672.5	+	10	2217	c.2179A>T	c.(2179-2181)Att>Ttt	p.I727F	EPHA6_ENST00000514100.1_Missense_Mutation_p.I119F|EPHA6_ENST00000442602.2_Missense_Mutation_p.I93F|EPHA6_ENST00000502694.1_Missense_Mutation_p.I119F	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	632	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AAGAATTCGTATTGAGAGAGT	0.358000													21	20					0	0	0.001882	0	0
SH2D7	646892	broad.mit.edu	37	15	78390796	78390796	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:78390796C>T	ENST00000328828.5	+	4	503	c.503C>T	c.(502-504)cCa>cTa	p.P168L	SH2D7_ENST00000409568.2_Missense_Mutation_p.P32L	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	168										endometrium(2)|kidney(2)|lung(3)	7						CCAGAAAACCCACCTGCCACG	0.607000													15	24					0	0	0.003163	0	0
RPL32P3	132241	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													6	176					0	0	0.003080	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574507	140574507	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140574507C>T	ENST00000239446.4	+	1	2566	c.2382C>T	c.(2380-2382)agC>agT	p.S794S		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		794					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGAAATAGCTTTGGATTTA	0.368000													17	36					0	0	0.004990	0	0
PGR	5241	broad.mit.edu	37	11	100933383	100933383	+	Silent	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:100933383T>G	ENST00000325455.5	-	4	3460	c.2007A>C	c.(2005-2007)ctA>ctC	p.L669L	PGR_ENST00000263463.5_Intron|PGR_ENST00000534013.1_Silent_p.L75L	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	669					cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	ATCTCTGGCTTAGGGCTTGGC	0.443000													7	603					0	0	0.004482	0	0
ZNF91	7644	broad.mit.edu	37	19	23544197	23544197	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544197T>C	ENST00000300619.7	-	4	1789	c.1584A>G	c.(1582-1584)agA>agG	p.R528R	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Silent_p.R496R	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	528						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTAAGGATTGTCTAAAAGCTT	0.343000													9	20					0	0	0.004482	0	0
FRMPD4	9758	broad.mit.edu	37	X	12701691	12701691	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:12701691C>T	ENST00000380682.1	+	6	1064	c.558C>T	c.(556-558)atC>atT	p.I186I		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	186					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						AGGTCATCATCAACGGCCAAG	0.443000													19	8					0	0	0.007413	0	0
JPH1	56704	broad.mit.edu	37	8	75233253	75233253	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:75233253G>C	ENST00000342232.4	-	1	310	c.270C>G	c.(268-270)ttC>ttG	p.F90L		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	90	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			AGCGCCCCTTGAAACCATGTG	0.667000													9	52					0	0	0.001368	0	0
DHX38	9785	broad.mit.edu	37	16	72143370	72143370	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:72143370C>T	ENST00000268482.3	+	25	3947	c.3438C>T	c.(3436-3438)ccC>ccT	p.P1146P	DHX38_ENST00000536867.1_Silent_p.P458P	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1146					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				AGCTGGGCCCCATGTTCTATA	0.637000													8	23					0	0	0.004482	0	0
POLK	51426	broad.mit.edu	37	5	74865317	74865317	+	Splice_Site	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:74865317G>T	ENST00000241436.4	+	4	580	c.408_splice	c.e4+1	p.L136_splice	POLK_ENST00000380481.3_Splice_Site_p.L46_splice|POLK_ENST00000506928.1_3'UTR|POLK_ENST00000504026.1_Splice_Site_p.L136_splice|POLK_ENST00000352007.5_Splice_Site_p.L136_splice|POLK_ENST00000508526.1_Splice_Site_p.L136_splice|POLK_ENST00000515295.1_Splice_Site_p.L136_splice	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	136	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TGAGTATGCTGGTAAGTAAAG	0.368000								DNA polymerases (catalytic subunits)					16	11					1.33834e-09	1.91099e-09	0.007413	1	0
CCDC57	284001	broad.mit.edu	37	17	80156247	80156247	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:80156247T>C	ENST00000389641.4	-	3	495	c.459A>G	c.(457-459)aaA>aaG	p.K153K	CCDC57_ENST00000392347.1_Silent_p.K153K|CCDC57_ENST00000392343.3_Silent_p.K153K			Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	153										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CCAGTGTCCATTTTAGATTTT	0.478000													3	34					0	0	0.000248	0	0
PIK3R4	30849	broad.mit.edu	37	3	130452572	130452572	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:130452572G>A	ENST00000356763.3	-	4	1827	c.1270C>T	c.(1270-1272)Cat>Tat	p.H424Y		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	424					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						TTGCTGAAATGCAAAAGATAT	0.413000													43	45					0	0	0.008740	0	0
HPX	3263	broad.mit.edu	37	11	6453230	6453230	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:6453230G>C	ENST00000265983.3	-	8	953	c.853C>G	c.(853-855)Ctg>Gtg	p.L285V		NM_000613.2	NP_000604.1	P02790	HEMO_HUMAN	hemopexin	285	Hemopexin-like 4.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(11)|prostate(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		CTGGTGTCCAGACGCCAGTAG	0.567000													66	31					0	0	0.003610	0	0
MROH9	80133	broad.mit.edu	37	1	170965783	170965783	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:170965783T>C	ENST00000367759.4	+	14	1627	c.1473T>C	c.(1471-1473)gcT>gcC	p.A491A	MROH9_ENST00000367758.3_Silent_p.A491A	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		GCTTTATTGCTAAGTAAGAAC	0.428000													4	136					0	0	0.000248	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135863925	135863925	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:135863925G>C	ENST00000264977.3	+	14	3987	c.3370G>C	c.(3370-3372)Gaa>Caa	p.E1124Q	PPP2R3A_ENST00000334546.2_Missense_Mutation_p.E503Q|PPP2R3A_ENST00000490467.1_Missense_Mutation_p.E388Q	NM_001190447.1|NM_002718.4	NP_001177376.1|NP_002709.2	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'', alpha	1124					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CTCTCCCTCTGAATTTGGAAA	0.358000													3	44					0	0	0.000248	0	0
IRS4	8471	broad.mit.edu	37	X	107977584	107977584	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:107977584G>A	ENST00000372129.2	-	1	2067	c.1991C>T	c.(1990-1992)aCg>aTg	p.T664M		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	664						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GCATTCTTTCGTGGCTCCTCT	0.512000													219	77					0	0	0.003610	0	0
ZNF280B	140883	broad.mit.edu	37	22	22843615	22843615	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:22843615G>T	ENST00000360412.2	-	4	884	c.109C>A	c.(109-111)Cat>Aat	p.H37N	ZNF280B_ENST00000406426.1_Missense_Mutation_p.H37N	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TCATTTACATGTTCCACACCA	0.418000													31	68					3.80469e-20	5.67836e-20	0.001786	1	0
ZFHX4	79776	broad.mit.edu	37	8	77764911	77764911	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:77764911T>C	ENST00000521891.2	+	10	6202	c.5754T>C	c.(5752-5754)ttT>ttC	p.F1918F	ZFHX4_ENST00000455469.2_Silent_p.F1873F|ZFHX4_ENST00000518282.1_Silent_p.F1892F|ZFHX4_ENST00000050961.6_Silent_p.F1873F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1873						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTTGGTTTTGAACTGGTCA	0.448000										HNSCC(33;0.089)			13	47					0	0	0.001855	0	0
LRP1B	53353	broad.mit.edu	37	2	141128783	141128783	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:141128783T>A	ENST00000389484.3	-	70	11811	c.10840A>T	c.(10840-10842)Aat>Tat	p.N3614Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3614	LDL-receptor class A 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTCTCCATTACATTTCAAA	0.299000										TSP Lung(27;0.18)			17	21					0	0	0.004990	0	0
PPM1D	8493	broad.mit.edu	37	17	58678140	58678140	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:58678140G>T	ENST00000305921.3	+	1	597	c.365G>T	c.(364-366)gGt>gTt	p.G122V		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	122	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			CACTTGTGGGGTTTCATCAAG	0.637000													7	35					1.26484e-09	1.81478e-09	0.003080	1	0
FBXW7	55294	broad.mit.edu	37	4	153247297	153247297	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:153247297G>A	ENST00000281708.4	-	10	2734	c.1505C>T	c.(1504-1506)gCa>gTa	p.A502V	FBXW7_ENST00000393956.3_Missense_Mutation_p.A326V|FBXW7_ENST00000263981.5_Missense_Mutation_p.A422V|FBXW7_ENST00000603841.1_Missense_Mutation_p.A502V|FBXW7_ENST00000603548.1_Missense_Mutation_p.A502V|FBXW7_ENST00000296555.5_Missense_Mutation_p.A384V	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	502					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GCGGACTGCTGCAACATGACC	0.468000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								41	53					0	0	0.002522	0	0
TIAF1	9220	broad.mit.edu	37	17	27400997	27400997	+	Missense_Mutation	SNP	T	T	C	rs115510379	by1000genomes	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:27400997T>C	ENST00000359450.6	-	1	4878	c.221A>G	c.(220-222)aAt>aGt	p.N74S	MYO18A_ENST00000531253.1_3'UTR|MYO18A_ENST00000527372.1_3'UTR|MYO18A_ENST00000529578.1_5'UTR|MYO18A_ENST00000354329.4_3'UTR|TIAF1_ENST00000408971.2_Missense_Mutation_p.N74S|MYO18A_ENST00000533112.1_3'UTR	NM_004740.3	NP_004731.2	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	74					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus				kidney(1)|lung(1)|urinary_tract(1)	3	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			AAATAGGTCATTGCACATAAC	0.552000													25	74					0	0	0.002780	0	0
LRP2	4036	broad.mit.edu	37	2	170129520	170129520	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:170129520T>C	ENST00000263816.3	-	15	2318	c.2033A>G	c.(2032-2034)cAc>cGc	p.H678R	LRP2_ENST00000443831.1_Missense_Mutation_p.H609R	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	678	EGF-like 3.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCTGTTCTGTGGCTGAGGAC	0.453000													57	100					0	0	0.003610	0	0
SLC45A2	51151	broad.mit.edu	37	5	33984637	33984637	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:33984637C>G	ENST00000382102.3	-	1	109	c.52G>C	c.(52-54)Gat>Cat	p.D18H	SLC45A2_ENST00000342059.3_Missense_Mutation_p.D18H|SLC45A2_ENST00000345083.5_Missense_Mutation_p.D18H|SLC45A2_ENST00000509381.1_Missense_Mutation_p.D18H|SLC45A2_ENST00000296589.4_Missense_Mutation_p.D18H	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	18					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						GGGCCATCATCAGCTAGGGAT	0.582000													18	58					0	0	0.004990	0	0
PRDM8	56978	broad.mit.edu	37	4	81123531	81123531	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:81123531C>T	ENST00000339711.4	+	10	2146	c.915C>T	c.(913-915)atC>atT	p.I305I	PRDM8_ENST00000504452.1_Silent_p.I305I|PRDM8_ENST00000415738.2_Silent_p.I305I	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	305	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						CCGACGGCATCGCCACGGGCG	0.746000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	5					0	0	0.000248	0	0
PDGFD	80310	broad.mit.edu	37	11	103870957	103870957	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:103870957G>A	ENST00000302251.5	-	2	584	c.133C>T	c.(133-135)Cga>Tga	p.R45*	PDGFD_ENST00000393158.2_Nonsense_Mutation_p.R51*	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	51					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TCATCTCTTCGGTACAAGTCT	0.458000													25	353					0	0	0.004656	0	0
C11orf84	144097	broad.mit.edu	37	11	63594564	63594564	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:63594564T>G	ENST00000294244.4	+	6	1398	c.1099T>G	c.(1099-1101)Tcc>Gcc	p.S367A		NM_138471.1	NP_612480.1	Q9BUA3	CK084_HUMAN	chromosome 11 open reading frame 84	367										endometrium(3)|kidney(1)|lung(3)|skin(1)	8						TCTGTCAGAATCCAGCACCAC	0.617000													11	44					0	0	0.001368	0	0
KCNB2	9312	broad.mit.edu	37	8	73480238	73480238	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:73480238A>G	ENST00000523207.1	+	2	857	c.269A>G	c.(268-270)gAt>gGt	p.D90G		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	90					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TATTTCTTTGATCGGCATCCA	0.493000													33	91					0	0	0.002445	0	0
STEAP2	261729	broad.mit.edu	37	7	89859238	89859238	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:89859238A>G	ENST00000287908.3	+	4	1466	c.1073A>G	c.(1072-1074)gAa>gGa	p.E358G	STEAP2_ENST00000394621.2_Missense_Mutation_p.E358G|STEAP2_ENST00000394626.1_Missense_Mutation_p.E358G|STEAP2_ENST00000402625.2_Missense_Mutation_p.E358G|STEAP2_ENST00000394632.1_Missense_Mutation_p.E358G|STEAP2_ENST00000394622.2_Missense_Mutation_p.E358G|STEAP2_ENST00000394629.2_Missense_Mutation_p.E358G	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	358	Ferric oxidoreductase.				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					TGGAGAATTGAAATGTATATC	0.373000													3	126					0	0	0.004672	0	0
FASTKD1	79675	broad.mit.edu	37	2	170428349	170428349	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:170428349G>C	ENST00000453153.2	-	2	537	c.191C>G	c.(190-192)tCa>tGa	p.S64*	FASTKD1_ENST00000453929.2_Nonsense_Mutation_p.S64*	NM_024622.3	NP_078898.3	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	64					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(5)|large_intestine(10)|lung(9)|ovary(4)|prostate(3)	37						TTGCTTTTCTGAAAGTATGGC	0.378000													30	46					0	0	0.002445	0	0
JAK3	3718	broad.mit.edu	37	19	17948809	17948809	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:17948809C>G	ENST00000458235.1	-	12	1732	c.1633G>C	c.(1633-1635)Gat>Cat	p.D545H	JAK3_ENST00000527670.1_Missense_Mutation_p.D545H|JAK3_ENST00000534444.1_Missense_Mutation_p.D545H	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	545	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						GCCTCCCCATCCACCACCTCA	0.567000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								67	95					0	0	0.003610	0	0
HFE	3077	broad.mit.edu	37	6	26091716	26091716	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:26091716A>G	ENST00000357618.5	+	3	637	c.515A>G	c.(514-516)cAc>cGc	p.H172R	HFE_ENST00000352392.4_Intron|HFE_ENST00000349999.4_Missense_Mutation_p.H84R|HFE_ENST00000317896.7_Intron|HFE_ENST00000353147.5_Intron|HFE_ENST00000461397.1_Missense_Mutation_p.H172R|HFE_ENST00000488199.1_Missense_Mutation_p.H84R|HFE_ENST00000397022.3_Missense_Mutation_p.H149R|HFE_ENST00000336625.8_Intron|HFE_ENST00000470149.1_Missense_Mutation_p.H172R|HFE_ENST00000309234.6_Missense_Mutation_p.H172R	NM_000410.3|NM_139006.2	NP_000401.1|NP_620575.1	Q30201	HFE_HUMAN	hemochromatosis	172	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding			endometrium(3)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGGGAAAGGCACAAGATTCGG	0.597000									Hemochromatosis				12	33					0	0	0.001368	0	0
ZNF99	7652	broad.mit.edu	37	19	22942464	22942464	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:22942464G>C	ENST00000397104.3	-	4	309	c.310C>G	c.(310-312)Caa>Gaa	p.Q104E	ZNF99_ENST00000596209.1_Missense_Mutation_p.Q83E					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CAAAAGTCTTGTGTAAAATGA	0.279000													16	17					0	0	0.003163	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310543	57310543	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:57310543A>T	ENST00000457912.1	+	2	482	c.482A>T	c.(481-483)gAg>gTg	p.E161V	SMTNL1_ENST00000527972.1_Missense_Mutation_p.E143V|SMTNL1_ENST00000399154.2_Missense_Mutation_p.E143V			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	143										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						GAGGAGAAAGAGGCCAAACCT	0.532000													4	18					0	0	0.000602	0	0
PICALM	8301	broad.mit.edu	37	11	85718613	85718613	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:85718613T>C	ENST00000526033.1	-	8	1095	c.779A>G	c.(778-780)gAc>gGc	p.D260G	PICALM_ENST00000393346.3_Missense_Mutation_p.D260G|PICALM_ENST00000532317.1_Missense_Mutation_p.D260G|PICALM_ENST00000356360.5_Missense_Mutation_p.D260G|PICALM_ENST00000528398.1_Missense_Mutation_p.D209G	NM_001206946.1|NM_007166.3	NP_001193875.1|NP_009097.2	Q13492	PICAL_HUMAN	phosphatidylinositol binding clathrin assembly protein	260					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				ATCACCTCTGTCAATTCCAAC	0.289000			T	"""MLLT10, MLL"""	"""TALL, AML, """								3	96					0	0	0.004672	0	0
ENPP2	5168	broad.mit.edu	37	8	120596204	120596204	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:120596204G>A	ENST00000427067.2	-	16	1621	c.1441C>T	c.(1441-1443)Cag>Tag	p.Q481*	ENPP2_ENST00000522826.1_Nonsense_Mutation_p.Q485*|ENPP2_ENST00000075322.6_Nonsense_Mutation_p.Q485*|ENPP2_ENST00000522167.1_Nonsense_Mutation_p.Q124*|ENPP2_ENST00000259486.6_Nonsense_Mutation_p.Q537*			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	485					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATCATACCTGCATGCTGTTG	0.363000													81	249					0	0	0.003610	0	0
NAPRT1	93100	broad.mit.edu	37	8	144658617	144658617	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:144658617C>T	ENST00000449291.2	-	7	1301	c.1007G>A	c.(1006-1008)cGa>cAa	p.R336Q	NAPRT1_ENST00000435154.3_Missense_Mutation_p.R336Q|NAPRT1_ENST00000276844.7_Missense_Mutation_p.R336Q|NAPRT1_ENST00000426292.3_Missense_Mutation_p.R336Q|RP11-661A12.9_ENST00000531730.1_RNA			Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain containing 1	336					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	6	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGCAGCAGCTCGGAAGACCTT	0.652000													18	40					0	0	0.006122	0	0
SPHAR	10638	broad.mit.edu	37	1	229440922	229440922	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:229440922A>G	ENST00000366688.3	+	1	794	c.41A>G	c.(40-42)tAt>tGt	p.Y14C	RAB4A_ENST00000366690.4_3'UTR	NM_006542.3	NP_006533.1	Q15513	SPHAR_HUMAN	S-phase response (cyclin related)	14					DNA replication							Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)				TGTTTTAGATATTTTGAGTTT	0.299000													26	32					0	0	0.003330	0	0
RGL2	5863	broad.mit.edu	37	6	33264552	33264552	+	Splice_Site	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:33264552A>C	ENST00000497454.1	-	4	737	c.240_splice	c.e4-1	p.V81_splice	RGL2_ENST00000437840.2_5'UTR|RGL2_ENST00000444031.2_5'UTR|PFDN6_ENST00000463584.1_Intron	NM_001243738.1|NM_004761.4	NP_001230667.1|NP_004752.1	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation stimulator-like 2	81					Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			breast(2)|cervix(2)|endometrium(7)|kidney(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	34						AGGCATAGGGACCTGGAGAAC	0.562000													21	31					0	0	0.008871	0	0
HEXIM1	10614	broad.mit.edu	37	17	43226879	43226879	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:43226879G>C	ENST00000332499.2	+	1	2196	c.322G>C	c.(322-324)Gaa>Caa	p.E108Q		NM_006460.2	NP_006451.1	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	108					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			breast(1)|kidney(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GCCGCCGGCAGAAGTGGAACC	0.677000											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	5					0	0	0.000602	0	0
CLEC18B	497190	broad.mit.edu	37	16	74455117	74455117	+	Silent	SNP	G	G	A	rs141907838	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:74455117G>A	ENST00000339953.5	-	1	173	c.52C>T	c.(52-54)Ctg>Ttg	p.L18L		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	18						extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						AGGAGGGCCAGGAGCACAGCC	0.682000													24	99					0	0	0.008361	0	0
NOVA1	4857	broad.mit.edu	37	14	26949229	26949229	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:26949229C>A	ENST00000539517.2	-	3	718	c.401G>T	c.(400-402)aGc>aTc	p.S134I	NOVA1_ENST00000465357.2_Missense_Mutation_p.S134I|NOVA1_ENST00000547619.1_Missense_Mutation_p.S134I|NOVA1_ENST00000344429.5_Missense_Mutation_p.S134I|NOVA1_ENST00000574031.1_Missense_Mutation_p.S134I|NOVA1_ENST00000267422.7_Missense_Mutation_p.S12I	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	137					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		TTGTAGAATGCTGACTGGTTC	0.418000													48	86					6.9144e-35	1.05312e-34	0.003610	1	0
DOCK7	85440	broad.mit.edu	37	1	63027299	63027299	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:63027299T>C	ENST00000251157.5	-	19	2221	c.2188A>G	c.(2188-2190)Atc>Gtc	p.I730V	DOCK7_ENST00000340370.5_Missense_Mutation_p.I730V	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	730	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TGTGTATGGATAGACGAAACA	0.294000													39	66					0	0	0.006999	0	0
LILRB4	11006	broad.mit.edu	37	19	55179390	55179390	+	Missense_Mutation	SNP	A	A	G	rs534751		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:55179390A>G	ENST00000391736.1	+	14	1582	c.1267A>G	c.(1267-1269)Aag>Gag	p.K423E	LILRB4_ENST00000270452.2_Missense_Mutation_p.K423E|LILRB4_ENST00000391733.3_Missense_Mutation_p.K424E|LILRB4_ENST00000430952.2_Missense_Mutation_p.K422E|LILRB4_ENST00000391734.3_Missense_Mutation_p.K370E	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	423						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CCTCAGACAGAAGGCAACTGA	0.622000													5	133					0	0	0.001168	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249107242	249107242	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:249107242G>A	ENST00000366472.5	-	6	1886	c.657C>T	c.(655-657)atC>atT	p.I219I	SH3BP5L_ENST00000411742.2_Silent_p.I187I|SH3BP5L_ENST00000475978.1_5'UTR	NM_030645.1	NP_085148.1	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	219								p.I219I(2)		endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGCTCTTGCCGATGGCCCTCC	0.652000													25	43					0	0	0.002096	0	0
FAM135B	51059	broad.mit.edu	37	8	139160898	139160898	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:139160898C>G	ENST00000395297.1	-	14	3483	c.3313G>C	c.(3313-3315)Gaa>Caa	p.E1105Q		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1105										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATCTTCAGTTCTTTTTTAAAT	0.368000										HNSCC(54;0.14)			10	55					0	0	0.008291	0	0
VTN	7448	broad.mit.edu	37	17	26696658	26696658	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:26696658C>G	ENST00000226218.4	-	3	1017	c.399G>C	c.(397-399)gaG>gaC	p.E133D	SEBOX_ENST00000536498.1_5'UTR|SARM1_ENST00000379061.4_Intron|CTB-96E2.3_ENST00000591482.1_RNA|TMEM199_ENST00000509083.1_Intron	NM_000638.3	NP_000629.3	P04004	VTNC_HUMAN	vitronectin	133					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			kidney(2)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	13	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	AGTCTATCCCCTCAGGCTTAG	0.622000													17	21					0	0	0.004007	0	0
RUNX1T1	862	broad.mit.edu	37	8	92983007	92983007	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:92983007C>T	ENST00000523629.1	-	11	1872	c.1418G>A	c.(1417-1419)cGg>cAg	p.R473Q	RUNX1T1_ENST00000422361.2_Missense_Mutation_p.R436Q|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.R446Q|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.R446Q|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.R436Q|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.R484Q|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.R473Q|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.R436Q	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	473					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTGGGCTTTCCGCTCCGCCTC	0.617000													27	29					0	0	0.004656	0	0
RFFL	117584	broad.mit.edu	37	17	33348470	33348470	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:33348470G>T	ENST00000315249.7	-	3	733	c.511C>A	c.(511-513)Cca>Aca	p.P171T	RFFL_ENST00000447669.2_Missense_Mutation_p.P171T|RFFL_ENST00000584655.1_Missense_Mutation_p.P171T|RFFL_ENST00000268850.7_Missense_Mutation_p.P171T|RFFL_ENST00000415395.2_Missense_Mutation_p.P171T|RFFL_ENST00000413582.2_Missense_Mutation_p.P171T|RFFL_ENST00000378516.2_Missense_Mutation_p.P171T|RAD51L3-RFFL_ENST00000593039.1_Intron|RFFL_ENST00000394597.2_Missense_Mutation_p.P171T			Q8WZ73	RFFL_HUMAN	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	171					apoptosis	membrane	ligase activity|zinc ion binding			kidney(1)|large_intestine(2)|lung(3)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		GAGGTAGGTGGAACCATGCTG	0.587000													13	19					2.27111e-07	3.212e-07	0.001368	1	0
KIFC2	90990	broad.mit.edu	37	8	145698668	145698668	+	Silent	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:145698668G>T	ENST00000301332.2	+	17	2729	c.2352G>T	c.(2350-2352)ccG>ccT	p.P784P	KIFC2_ENST00000301331.5_3'UTR	NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	784	Pro-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TCCGCTCACCGGGACCCCCTG	0.741000													7	16					0.000157383	0.000216402	0.003080	1	0
CNTN5	53942	broad.mit.edu	37	11	99715973	99715973	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:99715973G>C	ENST00000524871.1	+	6	846	c.556G>C	c.(556-558)Gaa>Caa	p.E186Q	CNTN5_ENST00000528682.1_Missense_Mutation_p.E186Q|CNTN5_ENST00000279463.3_Missense_Mutation_p.E186Q|CNTN5_ENST00000418526.2_Missense_Mutation_p.E112Q|CNTN5_ENST00000527185.1_Missense_Mutation_p.E186Q	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	186	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCTTAGTAGAGAAGCTACACT	0.338000													38	362					0	0	0.006230	0	0
POTEM	641455	broad.mit.edu	37	14	20010235	20010235	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:20010235A>G	ENST00000551509.1	-	5	974	c.923T>C	c.(922-924)gTt>gCt	p.V308A	RP11-244H18.1_ENST00000547584.1_lincRNA	NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	308										endometrium(4)|kidney(1)|lung(4)	9						AAGTATGAGAACAGTTCTAAA	0.368000													3	119					0	0	0.000248	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597187	136597187	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:136597187T>C	ENST00000531224.1	-	5	1728	c.1476A>G	c.(1474-1476)aaA>aaG	p.K492K	BCLAF1_ENST00000527759.1_Silent_p.K490K|BCLAF1_ENST00000353331.4_Silent_p.K490K|BCLAF1_ENST00000527536.1_Silent_p.K492K|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000392348.2_Silent_p.K490K	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	492					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.K492K(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ACTGAGTTTCTTTCTTTACTG	0.378000													31	201					0	0	0.008361	0	0
GPR64	10149	broad.mit.edu	37	X	19022962	19022962	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:19022962C>A	ENST00000379878.3	-	22	2068	c.1827G>T	c.(1825-1827)atG>atT	p.M609I	GPR64_ENST00000379869.3_Missense_Mutation_p.M625I|GPR64_ENST00000379876.1_Missense_Mutation_p.M601I|GPR64_ENST00000379873.2_Missense_Mutation_p.M625I|GPR64_ENST00000357544.3_Missense_Mutation_p.M595I|GPR64_ENST00000360279.4_Missense_Mutation_p.M603I|GPR64_ENST00000357991.3_Missense_Mutation_p.M622I|GPR64_ENST00000354791.3_Missense_Mutation_p.M609I|GPR64_ENST00000340581.3_Missense_Mutation_p.M506I|GPR64_ENST00000356606.4_Missense_Mutation_p.M611I	NM_001184833.1	NP_001171762.1	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	625	GPS.				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					TCAGAGCCATCATTTGAGCAG	0.338000													84	31					1.79992e-35	2.75554e-35	0.003610	1	0
RASL12	51285	broad.mit.edu	37	15	65347288	65347288	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:65347288G>T	ENST00000220062.4	-	5	1026	c.750C>A	c.(748-750)agC>agA	p.S250R	RASL12_ENST00000434605.2_Missense_Mutation_p.S239R|RASL12_ENST00000421977.3_Missense_Mutation_p.S231R	NM_016563.2	NP_057647.1	Q9NYN1	RASLC_HUMAN	RAS-like, family 12	250					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			lung(1)|ovary(1)|skin(1)|urinary_tract(1)	4						CCTTGCGCTTGCTCTGGGCCC	0.627000											OREG0023189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	15					2.23348e-06	3.11429e-06	0.004007	1	0
ADCY9	115	broad.mit.edu	37	16	4165167	4165167	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:4165167G>A	ENST00000294016.3	-	2	815	c.277C>T	c.(277-279)Ccc>Tcc	p.P93S		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	93					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TCGAACTTGGGGTCCCACCAG	0.706000													12	42					0	0	0.001368	0	0
PCIF1	63935	broad.mit.edu	37	20	44571864	44571864	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:44571864A>G	ENST00000372409.3	+	8	1166	c.802A>G	c.(802-804)Atg>Gtg	p.M268V		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	268						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						TCGTGAAATCATGAACGACAT	0.537000													24	128					0	0	0.004656	0	0
SPATA18	132671	broad.mit.edu	37	4	52943055	52943055	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:52943055G>T	ENST00000295213.4	+	7	1243	c.869G>T	c.(868-870)cGc>cTc	p.R290L	SPATA18_ENST00000419395.2_Missense_Mutation_p.R258L	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	290	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCCCCAAACCGCTCCAAGCTG	0.682000													15	28					0.000566183	0.00077136	0.004990	1	0
NPHS1	4868	broad.mit.edu	37	19	36335330	36335330	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:36335330C>T	ENST00000378910.5	-	15	1961	c.1962G>A	c.(1960-1962)ctG>ctA	p.L654L	NPHS1_ENST00000353632.6_Silent_p.L654L	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	654					cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGTCACCACCAGCACCTGCT	0.637000													3	3					0	0	0.004672	0	0
ABCC12	94160	broad.mit.edu	37	16	48138167	48138167	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:48138167T>G	ENST00000311303.3	-	20	3131	c.2786A>C	c.(2785-2787)aAc>aCc	p.N929T	ABCC12_ENST00000448542.1_Intron|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	929	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CTGCAGAAAGTTCTCTGCGTG	0.493000													15	310					0	0	0.003163	0	0
FHOD3	80206	broad.mit.edu	37	18	34298136	34298136	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr18:34298136G>C	ENST00000257209.4	+	16	2472	c.2350G>C	c.(2350-2352)Gag>Cag	p.E784Q	FHOD3_ENST00000445677.1_Missense_Mutation_p.E746Q|FHOD3_ENST00000590592.1_Missense_Mutation_p.E959Q|FHOD3_ENST00000359247.4_Missense_Mutation_p.E767Q|FHOD3_ENST00000591635.1_Intron	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	767					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CCCTGATGCTGAGCCCAATGA	0.542000													41	249					0	0	0.003214	0	0
STX6	10228	broad.mit.edu	37	1	180959168	180959168	+	Silent	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:180959168G>C	ENST00000258301.5	-	5	678	c.441C>G	c.(439-441)ctC>ctG	p.L147L	STX6_ENST00000542060.1_Silent_p.L46L	NM_005819.4	NP_005810.1	O43752	STX6_HUMAN	syntaxin 6	147					Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	10						TGGCTCTCTGGAGCTCTCGGT	0.557000													48	66					0	0	0.003610	0	0
TPTE	7179	broad.mit.edu	37	21	10933918	10933918	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:10933918C>A	ENST00000298232.7	-	16	1274	c.907G>T	c.(907-909)Gaa>Taa	p.E303*	TPTE_ENST00000342420.5_Nonsense_Mutation_p.E283*|TPTE_ENST00000361285.4_Nonsense_Mutation_p.E321*|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	321	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCATTTACTTCCTTGGTGAAA	0.333000													51	315					1.48341e-19	2.20286e-19	0.003610	1	0
FGF5	2250	broad.mit.edu	37	4	81188009	81188009	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:81188009T>C	ENST00000456523.3	+	1	217	c.31T>C	c.(31-33)Ttc>Ctc	p.F11L	FGF5_ENST00000312465.7_Missense_Mutation_p.F11L	NM_033143.2	NP_149134.1	P12034	FGF5_HUMAN	fibroblast growth factor 5	11					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22						CCTCCTCTTCTTCAGCCACCT	0.622000													32	42					0	0	0.003755	0	0
CCT2	10576	broad.mit.edu	37	12	69986801	69986801	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:69986801G>C	ENST00000543146.2	+	9	1137	c.655G>C	c.(655-657)Gaa>Caa	p.E219Q	CCT2_ENST00000544368.2_Missense_Mutation_p.E266Q|CCT2_ENST00000299300.6_Missense_Mutation_p.E266Q	NM_001198842.1	NP_001185771.1	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2 (beta)	266					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(1)	24	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAAGGTTGCAGAAATAGAACA	0.343000													13	35					0	0	0.004007	0	0
PCDH15	65217	broad.mit.edu	37	10	55568819	55568819	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr10:55568819C>G	ENST00000395445.1	-	36	5385	c.4991G>C	c.(4990-4992)aGa>aCa	p.R1664T	PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.R598T|PCDH15_ENST00000395446.1_Missense_Mutation_p.R860T|PCDH15_ENST00000395442.1_Missense_Mutation_p.R529T	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CATGGGCCTTCTTCTTGCAAG	0.463000										HNSCC(58;0.16)			11	25					0	0	0.008291	0	0
SYNE2	23224	broad.mit.edu	37	14	64494410	64494410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:64494410C>T	ENST00000358025.3	+	43	6843	c.6613C>T	c.(6613-6615)Cag>Tag	p.Q2205*	SYNE2_ENST00000344113.4_Nonsense_Mutation_p.Q2205*|SYNE2_ENST00000554584.1_Nonsense_Mutation_p.Q2205*|SYNE2_ENST00000357395.3_5'UTR	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2205					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GTTAAAATCTCAGGGAAACTA	0.403000													25	38					0	0	0.004656	0	0
OR2G3	81469	broad.mit.edu	37	1	247769130	247769130	+	Silent	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:247769130C>G	ENST00000320002.2	+	1	275	c.243C>G	c.(241-243)acC>acG	p.T81T	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCCTCAGACCTTAGTTAACT	0.458000													120	194					0	0	0.003610	0	0
KMT2C	58508	broad.mit.edu	37	7	151921619	151921619	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:151921619C>A	ENST00000355193.2	-	19	3277	c.3059G>T	c.(3058-3060)gGa>gTa	p.G1020V	KMT2C_ENST00000262189.6_Missense_Mutation_p.G1020V					lysine (K)-specific methyltransferase 2C																		CAGGAGTCTTCCTGGGTCAGT	0.488000													13	13					0.00400662	0.00540894	0.004007	1	0
FRG1BP	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													5	84					0	0	0.004482	0	0
SMG5	23381	broad.mit.edu	37	1	156243195	156243195	+	Silent	SNP	G	G	A	rs151161240	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:156243195G>A	ENST00000361813.5	-	6	735	c.591C>T	c.(589-591)gcC>gcT	p.A197A	SMG5_ENST00000368267.4_Silent_p.A197A	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	197					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					AAAATCTCTCGGCTAGCAGCT	0.468000													19	32					0	0	0.007413	0	0
TMEM117	84216	broad.mit.edu	37	12	44537363	44537363	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:44537363A>G	ENST00000266534.3	+	4	573	c.446A>G	c.(445-447)aAt>aGt	p.N149S	TMEM117_ENST00000536799.1_Intron|TMEM117_ENST00000551577.1_Missense_Mutation_p.N149S	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	149						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		GGCATCCGAAATGAAAGTTTC	0.408000													20	36					0	0	0.001882	0	0
SHANK2	22941	broad.mit.edu	37	11	70333469	70333469	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:70333469A>C	ENST00000338508.4	-	32	2931	c.2932T>G	c.(2932-2934)Ttc>Gtc	p.F978V	SHANK2_ENST00000409161.1_Missense_Mutation_p.F381V|SHANK2_ENST00000449833.2_Missense_Mutation_p.F382V|SHANK2_ENST00000423696.2_Missense_Mutation_p.F598V			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	598					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTGTTGCGGAAGTTGGCTTGC	0.587000													51	799					0	0	0.003610	0	0
MXRA5	25878	broad.mit.edu	37	X	3241328	3241328	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:3241328C>T	ENST00000217939.6	-	5	2552	c.2398G>A	c.(2398-2400)Gaa>Aaa	p.E800K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	800						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGGGGTACTTCTGTGCCCTTA	0.468000													27	16					0	0	0.006230	0	0
SH2B3	10019	broad.mit.edu	37	12	111886081	111886081	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:111886081T>C	ENST00000341259.2	+	8	2060	c.1703T>C	c.(1702-1704)aTa>aCa	p.I568T	SH2B3_ENST00000538307.1_Missense_Mutation_p.I366T	NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	568					blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						CTGCGGGCCATAGACAATCAG	0.562000													6	10					0	0	0.001984	0	0
PIK3C3	5289	broad.mit.edu	37	18	39629561	39629561	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr18:39629561C>G	ENST00000262039.4	+	21	2341	c.2255C>G	c.(2254-2256)aCa>aGa	p.T752R	PIK3C3_ENST00000398870.3_Missense_Mutation_p.T689R|PIK3C3_ENST00000593098.1_Missense_Mutation_p.T237R|PIK3C3_ENST00000589056.1_Missense_Mutation_p.T99R|PIK3C3_ENST00000587402.1_Missense_Mutation_p.T99R	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	752	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						CTTTTGCTAACAAAAACAGGT	0.378000										TSP Lung(28;0.18)			34	19					0	0	0.003271	0	0
SOX5	6660	broad.mit.edu	37	12	23716248	23716248	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:23716248C>G	ENST00000546136.1	-	10	1395	c.1393G>C	c.(1393-1395)Gat>Cat	p.D465H	SOX5_ENST00000541536.1_Intron|SOX5_ENST00000537393.1_Missense_Mutation_p.D443H|SOX5_ENST00000381381.2_Intron|SOX5_ENST00000545921.1_Missense_Mutation_p.D468H|SOX5_ENST00000396007.2_Missense_Mutation_p.D92H|SOX5_ENST00000451604.2_Missense_Mutation_p.D478H|SOX5_ENST00000309359.1_Missense_Mutation_p.D465H			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	478					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						ACCTTCCCATCAAGCACCTGT	0.418000													38	49					0	0	0.006999	0	0
DSCAML1	57453	broad.mit.edu	37	11	117387378	117387378	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:117387378G>A	ENST00000321322.6	-	8	1768	c.1767C>T	c.(1765-1767)atC>atT	p.I589I	DSCAML1_ENST00000527706.1_Silent_p.I319I	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	529					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGGATAGCCGATGACCCTGC	0.592000													7	23					0	0	0.003080	0	0
TRPM1	4308	broad.mit.edu	37	15	31294736	31294736	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:31294736T>C	ENST00000542188.1	-	27	4531	c.4218A>G	c.(4216-4218)agA>agG	p.R1406R	RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000256552.6_Silent_p.R1389R|TRPM1_ENST00000397795.2_Silent_p.R1367R	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1367					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGTCTGTCTGTCTTTCATCAT	0.378000													64	66					0	0	0.003610	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110416786	110416786	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:110416786C>G	ENST00000378402.5	+	15	1481	c.1377C>G	c.(1375-1377)taC>taG	p.Y459*		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	459					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTCCAGATACTATATTGAAA	0.299000										HNSCC(38;0.096)			9	16					0	0	0.000978	0	0
AHCY	191	broad.mit.edu	37	20	32879320	32879320	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:32879320C>T	ENST00000538132.1	-	5	765	c.379G>A	c.(379-381)Gag>Aag	p.E127K	AHCY_ENST00000468908.1_5'UTR|AHCY_ENST00000217426.2_Missense_Mutation_p.E155K	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	155					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						GTGGTCTCCTCAGAGATGCCT	0.527000													30	88					0	0	0.007291	0	0
SLC6A15	55117	broad.mit.edu	37	12	85266514	85266514	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:85266514G>A	ENST00000266682.5	-	8	1710	c.1169C>T	c.(1168-1170)cCc>cTc	p.P390L	SLC6A15_ENST00000309283.7_Missense_Mutation_p.P98L|SLC6A15_ENST00000552192.1_Missense_Mutation_p.P283L	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	390					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						GATATGATGGGGAATAATATC	0.323000													3	37					0	0	0.004672	0	0
COL11A1	1301	broad.mit.edu	37	1	103474059	103474059	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:103474059G>T	ENST00000358392.2	-	15	1996	c.1679C>A	c.(1678-1680)tCa>tAa	p.S560*	COL11A1_ENST00000512756.1_Nonsense_Mutation_p.S432*|COL11A1_ENST00000353414.4_Nonsense_Mutation_p.S509*|COL11A1_ENST00000370096.3_Nonsense_Mutation_p.S548*	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	548	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCCCCAGATGAACCAGGCCC	0.373000													14	36					1.3612e-06	1.90697e-06	0.003163	1	0
PRKDC	5591	broad.mit.edu	37	8	48697813	48697813	+	Silent	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:48697813G>A	ENST00000314191.2	-	78	11021	c.10965C>T	c.(10963-10965)ctC>ctT	p.L3655L	PRKDC_ENST00000338368.3_Silent_p.L3655L|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3656					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGAAGTCACTGAGCTTCATTC	0.363000								Non-homologous end-joining					12	33					0	0	0.001368	0	0
PCNT	5116	broad.mit.edu	37	21	47817314	47817314	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:47817314G>A	ENST00000359568.5	+	22	4459	c.4352G>A	c.(4351-4353)cGc>cAc	p.R1451H	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1451					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					TCTCAGCATCGCGGGTGTGCC	0.567000													29	23					0	0	0.007291	0	0
INPP4B	8821	broad.mit.edu	37	4	143094803	143094803	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:143094803T>G	ENST00000513000.1	-	17	1774	c.1341A>C	c.(1339-1341)ttA>ttC	p.L447F	INPP4B_ENST00000262992.4_Missense_Mutation_p.L447F|INPP4B_ENST00000308502.4_Missense_Mutation_p.L447F|INPP4B_ENST00000509777.1_Missense_Mutation_p.L447F|INPP4B_ENST00000508116.1_Missense_Mutation_p.L447F	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	447					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					AAAGCATCTTTAAAGAATTCT	0.388000													26	60					0	0	0.001786	0	0
VWA8	23078	broad.mit.edu	37	13	42293870	42293870	+	Silent	SNP	C	C	T	rs140209374		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr13:42293870C>T	ENST00000379310.3	-	26	3041	c.2973G>A	c.(2971-2973)ccG>ccA	p.P991P	VWA8_ENST00000281496.6_Silent_p.P991P	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		GACCTTCAGTCGGAAATTTCT	0.303000													28	14					0	0	0.005443	0	0
SDHAP1	255812	broad.mit.edu	37	3	195692347	195692347	+	RNA	SNP	G	G	A	rs62282794	by1000genomes	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:195692347G>A	ENST00000427841.1	-	0	2155					NR_003264.2																						TTCCTCCAGTGCTCCTCAAAG	0.572000													8	21					0	0	0.000978	0	0
ATP1A1	476	broad.mit.edu	37	1	116927412	116927412	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:116927412A>G	ENST00000537345.1	+	3	494	c.131A>G	c.(130-132)cAt>cGt	p.H44R	ATP1A1_ENST00000295598.5_Missense_Mutation_p.H44R|ATP1A1_ENST00000369496.4_Missense_Mutation_p.H13R	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	44					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TAGGATGATCATAAACTTAGC	0.313000													22	39					0	0	0.002780	0	0
KIF1B	23095	broad.mit.edu	37	1	10364177	10364177	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:10364177C>T	ENST00000377093.4	+	21	3087	c.2934C>T	c.(2932-2934)atC>atT	p.I978I	KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000377083.1_Silent_p.I978I|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377086.1_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GGACACATATCATCATAACAG	0.453000													55	67					0	0	0.003610	0	0
TMEM219	124446	broad.mit.edu	37	16	29979372	29979372	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:29979372A>T	ENST00000566848.1	+	3	849	c.382A>T	c.(382-384)Atc>Ttc	p.I128F	TMEM219_ENST00000279396.6_Missense_Mutation_p.I128F|TMEM219_ENST00000561899.2_Missense_Mutation_p.I128F|TMEM219_ENST00000414689.2_Missense_Mutation_p.I128F			Q86XT9	TM219_HUMAN	transmembrane protein 219	128						integral to membrane				large_intestine(1)|lung(1)|prostate(2)	4						ACTGGTCCTTATCACAGCCAG	0.507000													61	101					0	0	0.003610	0	0
P2RY10	27334	broad.mit.edu	37	X	78216656	78216656	+	Silent	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:78216656C>T	ENST00000171757.2	+	4	919	c.639C>T	c.(637-639)atC>atT	p.I213I	P2RY10_ENST00000544091.1_Silent_p.I213I	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	213						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						CAGTGATCATCATCGCATGGT	0.478000													38	13					0	0	0.006999	0	0
ZNF91	7644	broad.mit.edu	37	19	23544264	23544264	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544264G>T	ENST00000300619.7	-	4	1722	c.1517C>A	c.(1516-1518)aCt>aAt	p.T506N	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.T474N	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	506						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CTTATGTTTAGTAAGGGTTGA	0.363000													9	31					5.4927e-09	7.80542e-09	0.004482	1	0
MRPS10	55173	broad.mit.edu	37	6	42179587	42179587	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:42179587C>G	ENST00000053468.3	-	4	270	c.255G>C	c.(253-255)aaG>aaC	p.K85N		NM_018141.3	NP_060611.2	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	85					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|lung(1)	2	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			CCAATACAGCCTTATCGTGAC	0.388000													11	31					0	0	0.008291	0	0
WDSUB1	151525	broad.mit.edu	37	2	160139519	160139519	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:160139519G>C	ENST00000409990.3	-	2	318	c.62C>G	c.(61-63)tCc>tGc	p.S21C	WDSUB1_ENST00000392796.3_Missense_Mutation_p.S21C|WDSUB1_ENST00000409124.1_Missense_Mutation_p.S21C|WDSUB1_ENST00000359774.4_Missense_Mutation_p.S21C|WDSUB1_ENST00000358147.4_Missense_Mutation_p.S21C	NM_001128213.1	NP_001121685.1	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain containing 1	21						ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(3)|prostate(1)|stomach(3)	16						GAGGGAAAAGGAGAAGGCACA	0.413000													38	42					0	0	0.006230	0	0
C4orf36	132989	broad.mit.edu	37	4	87809368	87809368	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:87809368G>C	ENST00000473559.1	-	6	789	c.126C>G	c.(124-126)atC>atG	p.I42M	C4orf36_ENST00000295898.3_Missense_Mutation_p.I42M|C4orf36_ENST00000503001.1_5'UTR			Q96KX1	CD036_HUMAN	chromosome 4 open reading frame 36	42										breast(1)|kidney(1)|lung(1)|prostate(1)	4		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00141)		AAGGCAACTTGATATTGGCTA	0.398000													24	29					0	0	0.004656	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415528	105415528	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:105415528T>C	ENST00000333244.5	-	7	6379	c.6260A>G	c.(6259-6261)aAg>aGg	p.K2087R	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2087						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGGGGGCCCTTGAGGTCCAC	0.612000													127	200					0	0	0.003610	0	0
MRPL41	64975	broad.mit.edu	37	9	140446808	140446808	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:140446808T>G	ENST00000371443.5	+	2	1063	c.275T>G	c.(274-276)tTc>tGc	p.F92C		NM_032477.2	NP_115866.1	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	92					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(1)	2	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GCGCAGCTCTTCAGCGAAGCC	0.622000													13	29					0	0	0.003163	0	0
OTX1	5013	broad.mit.edu	37	2	63283274	63283274	+	Silent	SNP	T	T	C			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:63283274T>C	ENST00000366671.3	+	5	1164	c.888T>C	c.(886-888)caT>caC	p.H296H	OTX1_ENST00000282549.2_Silent_p.H296H	NM_001199770.1	NP_001186699.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	296	His-rich.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					accaccaccatcaccaccacc	0.642000													3	61					0	0	0.004672	0	0
HNRNPDL	9987	broad.mit.edu	37	4	83350560	83350560	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:83350560A>G	ENST00000295470.5	-	1	459	c.284T>C	c.(283-285)aTa>aCa	p.I95T	HNRNPDL_ENST00000602300.1_5'UTR|HNRNPDL_ENST00000502762.1_Missense_Mutation_p.I95T|HNRNPDL_ENST00000349655.4_5'UTR|HNRNPDL_ENST00000514511.1_5'UTR	NM_001207000.1|NM_031372.3	NP_001193929.1|NP_112740.1			heterogeneous nuclear ribonucleoprotein D-like																		GGAGCGTTGTATGGAGCTGGA	0.667000													19	50					0	0	0.008871	0	0
TFAP4	7023	broad.mit.edu	37	16	4308235	4308235	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:4308235C>T	ENST00000204517.6	-	7	1166	c.838G>A	c.(838-840)Gag>Aag	p.E280K		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	280					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						TGGGTGCCCTCGATGTGCTGG	0.657000													18	30					0	0	0.007413	0	0
ZMYM6	9204	broad.mit.edu	37	1	35452758	35452759	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:35452758_35452759insA	ENST00000357182.4	-	16	4151_4152	c.3924_3925insT	c.(3922-3927)ctcagtfs	p.S1309fs	ZMYM6_ENST00000373340.2_Intron|ZMYM6_ENST00000487874.1_Intron|ZMYM6_ENST00000493328.1_5'UTR	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	1309					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GATGTGACTGCAAGTCTTAGGG	0.366													27	55	---	---	---	---					
NOTCH2	4853	broad.mit.edu	37	1	120612003	120612004	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:120612003_120612004delGG	ENST00000256646.2	-	1	236_237	c.17_18delCC	c.(16-18)cfs	p.P6fs		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	6					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity	p.P6fs*27(2)		breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGCAGAGCGGGGCGCAGGGC	0.762			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				2	4	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													2	4	---	---	---	---					
LRP1B	53353	broad.mit.edu	37	2	141122323	141122323	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:141122323delG	ENST00000389484.3	-	72	12009	c.11038delC	c.(11038-11040)ttfs	p.L3680fs		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3680	LDL-receptor class A 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATTGCAAAGGAACTCATCA	0.403										TSP Lung(27;0.18)			46	112	---	---	---	---					
HSPD1P6	645548	broad.mit.edu	37	3	36810381	36810381	+	RNA	DEL	T	T	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:36810381delT	ENST00000424886.1	-	0	405																											GAGTGAGGCCttttttttttt	0.542													2	4	---	---	---	---					
SHROOM1	134549	broad.mit.edu	37	5	132161695	132161695	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:132161695delG	ENST00000378679.3	-	4	942	c.138delC	c.(136-138)cgfs	p.R46fs	SHROOM1_ENST00000319854.3_Frame_Shift_Del_p.R46fs|SHROOM1_ENST00000378676.1_Frame_Shift_Del_p.R46fs	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	46					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCGACTGCGTGCGCGGCTCGG	0.706													2	4	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708776	180708777	+	RNA	INS	-	-	G	rs140221514		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:180708776_180708777insG	ENST00000412295.2	+	0	238																											gggcggtaggagggggctggag	0.728													3	5	---	---	---	---					
HLA-A	3105	broad.mit.edu	37	6	29911958	29911959	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:29911958_29911959insGC	ENST00000396634.1	+	6	1020_1021	c.679_680insGC	c.(679-681)ctgfs	p.L227fs	HLA-A_ENST00000376809.5_Frame_Shift_Ins_p.L227fs|HLA-A_ENST00000376802.2_Frame_Shift_Ins_p.L227fs|HLA-A_ENST00000376806.5_Frame_Shift_Ins_p.L227fs			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	227	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						CACCCTGAGGTGCTGGGCCCTG	0.604									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			37	120	---	---	---	---					
PLEKHG1	57480	broad.mit.edu	37	6	151162005	151162006	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:151162005_151162006delGT	ENST00000367328.1	+	17	4443_4444	c.4131_4132delGT	c.(4129-4134)cagtfs	p.QC1377fs	PLEKHG1_ENST00000358517.2_Frame_Shift_Del_p.QC1377fs	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	1377			Q -> P (in dbSNP:rs58786678).		regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		AAAAATTTCAGTGTCTCAGTTC	0.366													13	94	---	---	---	---					
CNTNAP3B	728577	broad.mit.edu	37	9	43844265	43844265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:43844265delG	ENST00000377564.3	+	10	1992	c.1599delG	c.(1597-1599)gcfs	p.A533fs		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	533	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCAGGGGGCGCTGGGGAGTT	0.542													4	2	---	---	---	---					
HEATR5A	25938	broad.mit.edu	37	14	31819914	31819915	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:31819914_31819915insA	ENST00000543095.2	-	17	2604_2605	c.2420_2421insT	c.(2419-2421)attfs	p.I807fs	HEATR5A_ENST00000439727.1_Frame_Shift_Ins_p.I514fs|HEATR5A_ENST00000404677.3_Frame_Shift_Ins_p.I807fs|HEATR5A_ENST00000389961.3_Frame_Shift_Ins_p.I801fs|HEATR5A_ENST00000439348.1_Frame_Shift_Ins_p.I801fs	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	801							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		GCTGTTCCAATATAAGAAGCCT	0.351													6	10	---	---	---	---					
CLK3	1198	broad.mit.edu	37	15	74919886	74919888	+	In_Frame_Del	DEL	GAG	GAG	-	rs149199059		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:74919886_74919888delGAG	ENST00000395066.3	+	9	1824_1826	c.1363_1365delGAG	c.(1363-1365)del	p.E456del	CLK3_ENST00000348245.3_3'UTR|CLK3_ENST00000345005.4_In_Frame_Del_p.E308del|CLK3_ENST00000352989.5_In_Frame_Del_p.E285del	NM_001130028.1	NP_001123500.1	P49761	CLK3_HUMAN	CDC-like kinase 3	456	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)|stomach(2)|urinary_tract(1)	15						TCAGAGCTGTGAGGAGAAGTCAG	0.576													54	54	---	---	---	---					
LAMP5	24141	broad.mit.edu	37	20	9496163	9496180	+	In_Frame_Del	DEL	CTGAAAAAGATATATTTG	CTGAAAAAGATATATTTG	-			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:9496163_9496180delCTGAAAAAGATATATTTG	ENST00000246070.2	+	2	620_637	c.128_145delCTGAAAAAGATATATTTG	c.(127-147)ctg>c	p.PEKDIFV43del	LAMP5_ENST00000427562.2_In_Frame_Del_p.PEKDIFV43del	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	43						integral to membrane											TCCACTAACCCTGAAAAAGATATATTTGTGGTGCGGGA	0.436													24	96	---	---	---	---					
ANKRD20A11P	391267	broad.mit.edu	37	21	15343608	15343609	+	RNA	INS	-	-	A			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:15343608_15343609insA	ENST00000344693.5	-	0	736					NR_027270.1																						TAAAACAGCAGAAAAAATTAAT	0.272													8	150	---	---	---	---					
