Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	A	rs121913233		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:533874T>A	ENST00000417302.1	-	3	369	c.182A>T	c.(181-183)cAg>cTg	p.Q61L	HRAS_ENST00000397596.2_Missense_Mutation_p.Q61L|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61L|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61L|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61L	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			48	122					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97084489	97084489	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:97084489G>A	ENST00000335456.7	-	3	856	c.836C>T	c.(835-837)gCg>gTg	p.A279V	NUTM2F_ENST00000341207.4_Missense_Mutation_p.A279V|NUTM2F_ENST00000253262.4_Missense_Mutation_p.A279V					NUT family member 2F																		TCACTTTTCCGCCATCTCGTA	0.632000													33	154					0	0	1	0	0
RPL39L	116832	broad.mit.edu	37	3	186839066	186839066	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:186839066G>C	ENST00000296277.4	-	3	425	c.23C>G	c.(22-24)aCc>aGc	p.T8S	RPL39L_ENST00000433055.1_Missense_Mutation_p.T8S|RPL39L_ENST00000455270.1_Missense_Mutation_p.T8S	NM_052969.1	NP_443201.1	Q96EH5	RL39L_HUMAN	ribosomal protein L39-like	8					spermatogenesis|translation	cytosolic large ribosomal subunit	structural constituent of ribosome					all_cancers(143;2.61e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.87e-18)	GBM - Glioblastoma multiforme(93;0.0745)		TCGCTTAATGGTGAAAGTCTT	0.448000													42	88					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127549502	127549502	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:127549502G>A	ENST00000373580.3	+	2	339	c.339G>A	c.(337-339)gcG>gcA	p.A113A		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	113								p.A113A(1)		endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						AAAAGCAGGCGCCCGAGCTCC	0.572000													20	49					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													4	19					0	0	1	0	0
MECR	51102	broad.mit.edu	37	1	29533365	29533365	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:29533365C>T	ENST00000373791.3	-	4	603	c.231G>A	c.(229-231)ccG>ccA	p.P77P	MECR_ENST00000263702.6_Silent_p.P153P|MECR_ENST00000489248.1_5'UTR	NM_001024732.1|NM_016011.2	NP_001019903.1|NP_057095.2	Q9BV79	MECR_HUMAN	mitochondrial trans-2-enoyl-CoA reductase	153					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)	11		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		GGATGTCACTCGGAACTTGGA	0.567000													4	97					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31934589	31934589	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:31934589G>A	ENST00000375394.2	+	19	2419	c.2306G>A	c.(2305-2307)aGc>aAc	p.S769N	SKIV2L_ENST00000544581.1_Missense_Mutation_p.S576N	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	769						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						ATGAAGAGGAGCTTCTCTGAG	0.562000													29	82					0	0	1	0	0
LPPR3	79948	broad.mit.edu	37	19	814640	814640	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:814640C>T	ENST00000359894.2	-	6	772	c.709G>A	c.(709-711)Gag>Aag	p.E237K	LPPR3_ENST00000520876.3_Intron	NM_024888.2	NP_079164.1	Q6T4P5	LPPR3_HUMAN		219						integral to membrane	phosphatidate phosphatase activity										AGGGAGGGCTCCCCACGGGTC	0.652000													4	90					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1585084	1585084	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:1585084G>A	ENST00000590550.2	-	1	445	c.72C>T	c.(70-72)cgC>cgT	p.R24R	MBD3_ENST00000156825.1_Silent_p.R80R|MBD3_ENST00000434436.3_Silent_p.R80R|MBD3_ENST00000585967.1_5'UTR|MBD3_ENST00000592012.1_Silent_p.R48R			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	80	MBD.				transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTAGCGCACGCGCTGGCGGC	0.662000													8	44					0	0	1	0	0
P2RX4	5025	broad.mit.edu	37	12	121666390	121666390	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:121666390C>G	ENST00000337233.4	+	6	887	c.579C>G	c.(577-579)atC>atG	p.I193M	P2RX4_ENST00000540930.1_3'UTR|P2RX4_ENST00000359949.7_Missense_Mutation_p.I209M|P2RX4_ENST00000543171.1_Missense_Mutation_p.I92M|P2RX4_ENST00000541532.1_3'UTR	NM_001261397.1|NM_001261398.1|NM_002560.2	NP_001248326.1|NP_001248327.1|NP_002551.2	Q99571	P2RX4_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 4	193					endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding			breast(1)|kidney(4)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAACAACATCTGGTATCCCA	0.373000													5	32					0	0	1	0	0
AKR1B10	57016	broad.mit.edu	37	7	134223689	134223689	+	Silent	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:134223689C>G	ENST00000359579.4	+	9	1148	c.828C>G	c.(826-828)gtC>gtG	p.V276V		NM_020299.4	NP_064695.3	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10 (aldose reductase)	276					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(9)|skin(5)	20						CTTTCCAGGTCTTTGACTTTA	0.483000													4	57					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513418	78513418	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:78513418G>T	ENST00000397909.2	+	15	3615	c.3442G>T	c.(3442-3444)Ggc>Tgc	p.G1148C	NAV3_ENST00000228327.6_Missense_Mutation_p.G1148C|NAV3_ENST00000536525.2_Missense_Mutation_p.G1148C|NAV3_ENST00000266692.7_Missense_Mutation_p.G1148C			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1148	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CAGCACCAGTGGCATTCCTGG	0.537000										HNSCC(70;0.22)			25	75					7.92952e-12	8.39472e-12	1	1	0
COL7A1	1294	broad.mit.edu	37	3	48611304	48611304	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:48611304C>T	ENST00000328333.8	-	80	6628	c.6521G>A	c.(6520-6522)gGc>gAc	p.G2174D	COL7A1_ENST00000454817.1_Missense_Mutation_p.G2142D	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2174	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCAGGGGGGCCTCTTGGACC	0.602000													5	40					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93648935	93648935	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:93648935C>T	ENST00000343253.7	+	2	519	c.17C>T	c.(16-18)tCa>tTa	p.S6L	CCDC18_ENST00000401026.3_Missense_Mutation_p.S6L|CCDC18_ENST00000557479.1_Missense_Mutation_p.S124L|CCDC18_ENST00000338949.4_5'UTR|CCDC18_ENST00000334652.5_5'UTR			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	6										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TCTAGTTCATCAGACTACTAT	0.303000													13	36					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56651665	56651665	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:56651665C>G	ENST00000267116.7	-	2	179	c.58G>C	c.(58-60)Gat>Cat	p.D20H		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	20							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						TCCTCCACATCTCGGCTAAAG	0.637000													5	54					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197878343	197878343	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:197878343G>T	ENST00000328737.2	-	18	1817	c.1741C>A	c.(1741-1743)Ctg>Atg	p.L581M	ANKRD44_ENST00000337207.5_Missense_Mutation_p.L581M|ANKRD44_ENST00000282272.8_Missense_Mutation_p.L598M|ANKRD44_ENST00000450567.1_Missense_Mutation_p.L581M			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	606							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AAGGCAGCCAGATCCAGAGCA	0.502000													9	269					1.33987e-11	1.4147e-11	1	1	0
MSLNL	401827	broad.mit.edu	37	16	823222	823222	+	Silent	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:823222C>A	ENST00000293892.3	-	10	2045	c.2046G>T	c.(2044-2046)ctG>ctT	p.L682L	MSLNL_ENST00000442466.1_Silent_p.L331L			Q96KJ4	MSLNL_HUMAN	mesothelin-like	331					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						TGCAGCCATCCAGGCAGGACT	0.632000													4	86					0.014758	0.0148327	1	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755803	140755803	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:140755803G>A	ENST00000517434.1	+	1	2153	c.2153G>A	c.(2152-2154)cGc>cAc	p.R718H	PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACTGCAGCGCTGGCACAAG	0.647000													5	207					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64769418	64769418	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:64769418G>A	ENST00000536360.1	-	2	896	c.83C>T	c.(82-84)tCa>tTa	p.S28L				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	28					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AGAACTGTATGAAAGCCTGTG	0.363000													44	155					0	0	1	0	0
XPC	7508	broad.mit.edu	37	3	14187459	14187459	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:14187459G>A	ENST00000285021.7	-	16	3019	c.2805C>T	c.(2803-2805)ttC>ttT	p.F935F	XPC_ENST00000449060.2_Silent_p.F898F|RP11-434D12.1_ENST00000601399.1_RNA|AC093495.4_ENST00000420253.1_RNA	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	935	Interaction with ERCC2 and GTF2H1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GCTCAAATGGGAACAGGTGGG	0.592000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				26	77					0	0	1	0	0
EIF5A2	56648	broad.mit.edu	37	3	170625446	170625446	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:170625446C>A	ENST00000295822.2	-	2	335	c.150G>T	c.(148-150)aaG>aaT	p.K50N	EIF5A2_ENST00000460117.1_Intron|EIF5A2_ENST00000487522.1_Missense_Mutation_p.K50N|EIF5A2_ENST00000474096.1_Missense_Mutation_p.K50N	NM_020390.5	NP_065123.1	Q9GZV4	IF5A2_HUMAN	eukaryotic translation initiation factor 5A2	50					mRNA transport|peptidyl-lysine modification to hypusine|polyamine homeostasis|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein transport|spermatogenesis|translational frameshifting|transmembrane transport	cytosol|endoplasmic reticulum membrane|nuclear pore	protein binding|ribosome binding|translation elongation factor activity			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	3	all_cancers(22;1.61e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;9.8e-16)|Lung(28;4.28e-15)			CATGACCATGCTTTCCAGTTT	0.468000													57	144					7.41606e-26	8.00047e-26	1	1	0
SLC6A5	9152	broad.mit.edu	37	11	20648345	20648345	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:20648345G>A	ENST00000525748.1	+	8	1625	c.1352G>A	c.(1351-1353)tGg>tAg	p.W451*		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	451					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	GCTGGGATCTGGTACTTCATC	0.557000													35	124					0	0	1	0	0
SCAMP3	10067	broad.mit.edu	37	1	155227141	155227141	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:155227141G>A	ENST00000355379.3	-	6	914	c.636C>T	c.(634-636)ttC>ttT	p.F212F	SCAMP3_ENST00000472397.1_5'UTR|SCAMP3_ENST00000302631.3_Silent_p.F238F	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	238					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGAAGAAAATGAAGAAGAAAA	0.473000													8	28					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106321164	106321164	+	RNA	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:106321164C>T	ENST00000390559.2	-	0	824																											TGGGGTGGCTCTCGGAGATGT	0.597000													28	55					0	0	1	0	0
GNAI1	2770	broad.mit.edu	37	7	79840284	79840284	+	Splice_Site	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:79840284G>C	ENST00000351004.3	+	6	963		c.e6-1		GNAI1_ENST00000457358.2_Splice_Site	NM_002069.5	NP_002060.4	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1						cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	19						CCTCTTAACAGAATGTTTGAT	0.398000													24	64					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72184108	72184108	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:72184108G>T	ENST00000340726.3	-	10	1490	c.851C>A	c.(850-852)tCa>tAa	p.S284*	EYA1_ENST00000303824.7_Nonsense_Mutation_p.S278*|EYA1_ENST00000388741.2_Nonsense_Mutation_p.S250*|EYA1_ENST00000388742.4_Nonsense_Mutation_p.S284*|EYA1_ENST00000419131.1_Nonsense_Mutation_p.S279*|EYA1_ENST00000388740.3_Nonsense_Mutation_p.S251*|EYA1_ENST00000388743.2_Nonsense_Mutation_p.S283*	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	284					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AATGGGTGTTGATGGGCTGTG	0.448000													10	322					0.000673444	0.000682034	1	1	0
ATF4	468	broad.mit.edu	37	22	39917485	39917485	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:39917485T>C	ENST00000337304.2	+	1	917	c.35T>C	c.(34-36)tTg>tCg	p.L12S	ATF4_ENST00000404241.2_Missense_Mutation_p.L12S|ATF4_ENST00000396680.1_Missense_Mutation_p.L12S	NM_001675.2	NP_001666.2	P18848	ATF4_HUMAN	activating transcription factor 4	12					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	Melanoma(58;0.04)					AGCGAGGTGTTGGTGGGGGAC	0.517000													36	105					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31737492	31737492	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:31737492G>T	ENST00000375686.3	-	9	1514	c.1277C>A	c.(1276-1278)aCc>aAc	p.T426N	VWA7_ENST00000375688.4_Missense_Mutation_p.T426N|VWA7_ENST00000447450.1_Missense_Mutation_p.T426N|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	426						extracellular region											CACCTGGTTGGTGAGAAAGGC	0.597000													7	132					0.0293803	0.0294545	1	1	0
OR52N2	390077	broad.mit.edu	37	11	5842217	5842217	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:5842217G>A	ENST00000317037.2	+	1	674	c.652G>A	c.(652-654)Gta>Ata	p.V218I	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTATCTCTGTATCTTACAC	0.448000													7	219					0	0	1	0	0
BCAR3	8412	broad.mit.edu	37	1	94027950	94027950	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:94027950C>G	ENST00000370244.1	-	14	2614	c.2326G>C	c.(2326-2328)Gaa>Caa	p.E776Q	BCAR3_ENST00000539242.1_Missense_Mutation_p.E452Q|BCAR3_ENST00000260502.6_Missense_Mutation_p.E776Q|BCAR3_ENST00000370247.3_Missense_Mutation_p.E685Q|BCAR3_ENST00000370243.1_Missense_Mutation_p.E776Q	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	776	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TTGCAGATTTCATTCATTTCT	0.353000													27	49					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5699628	5699628	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:5699628C>G	ENST00000305836.5	-	4	852	c.550G>C	c.(550-552)Gat>Cat	p.D184H	TRIM5_ENST00000483835.1_5'UTR|TRIM5_ENST00000396847.3_Missense_Mutation_p.D184H|TRIM5_ENST00000380027.1_Missense_Mutation_p.D184H|TRIM5_ENST00000396853.4_Missense_Mutation_p.D184H|TRIM5_ENST00000396855.3_Missense_Mutation_p.D184H|TRIM5_ENST00000380034.3_Missense_Mutation_p.D184H			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	184					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TGCTCAAAATCTGCCAAGACG	0.468000													4	128					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97852281	97852281	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:97852281C>T	ENST00000354565.2	+	1	740	c.740C>T	c.(739-741)tCt>tTt	p.S247F	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						CATCTCTTCTCTGTCTCTTTA	0.413000													38	92					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42266425	42266425	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:42266425C>G	ENST00000319511.6	+	2	661	c.11C>G	c.(10-12)tCt>tGt	p.S4C	TMUB2_ENST00000538716.2_Missense_Mutation_p.S24C|TMUB2_ENST00000589184.1_Missense_Mutation_p.S4C|TMUB2_ENST00000587172.1_Missense_Mutation_p.S4C|TMUB2_ENST00000587989.1_Missense_Mutation_p.S24C|TMUB2_ENST00000446571.3_Missense_Mutation_p.S4C|TMUB2_ENST00000592825.1_Missense_Mutation_p.S4C|TMUB2_ENST00000357984.3_Missense_Mutation_p.S4C|TMUB2_ENST00000590235.1_Missense_Mutation_p.S4C|TMUB2_ENST00000589785.1_Missense_Mutation_p.S4C|TMUB2_ENST00000589856.1_Missense_Mutation_p.S4C	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	24						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		ATGGAGCTCTCTGATGTCACC	0.572000													24	41					0	0	1	0	0
ATOH7	220202	broad.mit.edu	37	10	69991147	69991147	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:69991147C>T	ENST00000373673.3	-	1	724	c.288G>A	c.(286-288)ctG>ctA	p.L96L		NM_145178.3	NP_660161.1	Q8N100	ATOH7_HUMAN	atonal homolog 7 (Drosophila)	96					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding										CGGCCTCGGCCAGGATCCGGG	0.647000													6	36					0	0	1	0	0
ISG20L2	81875	broad.mit.edu	37	1	156693183	156693183	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:156693183G>C	ENST00000313146.6	-	3	1802	c.1020C>G	c.(1018-1020)gtC>gtG	p.V340V	ISG20L2_ENST00000368219.1_Silent_p.V340V|ISG20L2_ENST00000472824.1_5'UTR	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	340	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTTCCCACTCGACTTCAACCA	0.557000													65	184					0	0	1	0	0
GATA6	2627	broad.mit.edu	37	18	19762952	19762952	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr18:19762952C>G	ENST00000269216.3	+	6	1845	c.1568C>G	c.(1567-1569)tCa>tGa	p.S523*	GATA6_ENST00000581694.1_Nonsense_Mutation_p.S523*	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	523					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			TCTTCTAACTCAGATGATTGC	0.388000													25	85					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684915	100684915	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:100684915C>T	ENST00000306151.4	+	3	10282	c.10218C>T	c.(10216-10218)gtC>gtT	p.V3406V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3406	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTATGCCTGTCAGCACCACGC	0.493000													24	634					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158613167	158613167	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:158613167C>T	ENST00000368148.3	-	31	4567	c.4387G>A	c.(4387-4389)Gat>Aat	p.D1463N	SPTA1_ENST00000368147.3_Missense_Mutation_p.D1463N	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1463					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TAGTGTTCATCAGCAATGAGG	0.448000													18	44					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86896618	86896618	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:86896618C>G	ENST00000370565.4	+	4	711	c.549C>G	c.(547-549)ttC>ttG	p.F183L		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	183					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		ACAAACCTTTCTACATAAATG	0.353000													33	79					0	0	1	0	0
INTS6-AS1	100507398	broad.mit.edu	37	13	52035228	52035228	+	RNA	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:52035228G>A	ENST00000594959.1	+	0	411				INTS6-AS1_ENST00000595997.1_RNA|INTS6-AS1_ENST00000593429.1_RNA|INTS6-AS1_ENST00000602089.1_RNA|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000601572.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000601318.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|RPS4XP16_ENST00000595905.1_RNA|INTS6-AS1_ENST00000601034.1_RNA|INTS6-AS1_ENST00000597745.1_RNA|INTS6-AS1_ENST00000594604.1_RNA|INTS6-AS1_ENST00000594488.1_RNA|INTS6-AS1_ENST00000599315.1_RNA|INTS6-AS1_ENST00000598864.1_RNA|INTS6-AS1_ENST00000594358.1_RNA|INTS6-AS1_ENST00000600477.1_RNA|INTS6-AS1_ENST00000593928.1_RNA|INTS6-AS1_ENST00000593709.1_RNA|INTS6-AS1_ENST00000596303.1_RNA|INTS6-AS1_ENST00000434512.1_RNA|INTS6-AS1_ENST00000596180.1_RNA																							GTGCTAACCTGGGAAGAATTG	0.443000													4	37					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033179	82033179	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:82033179C>T	ENST00000328945.5	-	3	846	c.719G>A	c.(718-720)aGa>aAa	p.R240K		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	240					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CTTGTCAGCTCTCAGGGCTTC	0.557000													8	179					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58489953	58489953	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:58489953G>A	ENST00000341164.4	-	7	2715	c.2095C>T	c.(2095-2097)Cgg>Tgg	p.R699W	ZNF606_ENST00000536132.1_Missense_Mutation_p.R609W	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	699					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TGAGTTCTCCGGTGTGCAATG	0.408000													20	72					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36216480	36216480	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:36216480G>A	ENST00000222270.7	+	12	3743	c.3743G>A	c.(3742-3744)cGc>cAc	p.R1248H	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Missense_Mutation_p.R1248H	NM_014727.1	NP_055542.1																					TGCTGCCGTCGCTGCAAATTC	0.632000													63	169					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51961243	51961243	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:51961243C>G	ENST00000321424.3	-	1	465	c.399G>C	c.(397-399)tgG>tgC	p.W133C	SIGLEC8_ENST00000340550.5_Missense_Mutation_p.W133C|SIGLEC8_ENST00000430817.1_Missense_Mutation_p.W133C	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	133					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity	p.W133C(1)		NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ATTTGTAACTCCATTTCATGC	0.502000													5	164					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65154392	65154392	+	RNA	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:65154392C>T	ENST00000430126.2	+	0	876																											ACCAAGTACCCTACTGATAGG	0.408000													11	31					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62398117	62398117	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:62398117G>C	ENST00000346178.4	-	12	1423	c.1408C>G	c.(1408-1410)Cag>Gag	p.Q470E	GANAB_ENST00000534779.1_Missense_Mutation_p.Q356E|GANAB_ENST00000356638.3_Missense_Mutation_p.Q448E|GANAB_ENST00000540933.1_Missense_Mutation_p.Q351E	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	448					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GTGCGGGGCTGAGGGAAGCGA	0.547000													9	50					0	0	1	0	0
ODF2	4957	broad.mit.edu	37	9	131256853	131256853	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:131256853C>T	ENST00000303890.5	+	19	2330	c.1745C>T	c.(1744-1746)aCg>aTg	p.T582M	ODF2_ENST00000393533.2_Missense_Mutation_p.T606M|ODF2_ENST00000372791.3_Missense_Mutation_p.T587M|ODF2_ENST00000448249.3_Missense_Mutation_p.T525M|ODF2_ENST00000434106.2_Missense_Mutation_p.T606M|ODF2_ENST00000546203.1_Missense_Mutation_p.T587M|ODF2_ENST00000372807.5_Missense_Mutation_p.T601M|ODF2_ENST00000351030.3_Missense_Mutation_p.T601M|ODF2_ENST00000444119.2_Missense_Mutation_p.T582M|ODF2_ENST00000372796.4_Missense_Mutation_p.T606M|ODF2_ENST00000372814.3_Missense_Mutation_p.T650M	NM_002540.4	NP_002531.3	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2	606					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			autonomic_ganglia(1)|breast(7)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	37						CTGAAGATCACGGAGGCGAAG	0.567000													33	70					0	0	1	0	0
SOGA1	140710	broad.mit.edu	37	20	35443662	35443662	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr20:35443662G>A	ENST00000237536.4	-	5	2524	c.2183C>T	c.(2182-2184)aCg>aTg	p.T728M	SOGA1_ENST00000279034.5_Missense_Mutation_p.T490M|SOGA1_ENST00000456801.2_Missense_Mutation_p.T331M|SOGA1_ENST00000357779.3_Missense_Mutation_p.T490M	NM_080627.2	NP_542194.2	O94964	K0889_HUMAN	suppressor of glucose, autophagy associated 1	490										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						TGCCTTCCGCGTGAAGGCATT	0.622000													33	97					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111628751	111628751	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:111628751G>A	ENST00000435970.1	-	33	9647	c.8831C>T	c.(8830-8832)tCg>tTg	p.S2944L	REV3L_ENST00000368805.1_Missense_Mutation_p.S3022L|REV3L_ENST00000358835.3_Missense_Mutation_p.S3022L|REV3L_ENST00000368802.3_Missense_Mutation_p.S3022L|REV3L_ENST00000462119.1_5'UTR			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	3022					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TTCACTTCGCGAGGAGCTGGT	0.423000								DNA polymerases (catalytic subunits)					21	50					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113330987	113330987	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:113330987C>G	ENST00000264852.4	+	19	2638	c.1912C>G	c.(1912-1914)Ctg>Gtg	p.L638V	SIDT1_ENST00000463226.1_3'UTR|SIDT1_ENST00000393830.3_Missense_Mutation_p.L638V	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	638						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						AATCCACGTTCTGGCCTCGCT	0.418000													15	45					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8020224	8020224	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:8020224G>A	ENST00000380149.1	-	2	720	c.690C>T	c.(688-690)taC>taT	p.Y230Y	ALOXE3_ENST00000448843.2_Silent_p.Y74Y|ALOXE3_ENST00000318227.3_Silent_p.Y206Y			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	74	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						GGAAGAAAGCGTAGCGCTCCT	0.557000													27	48					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56904069	56904069	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:56904069C>T	ENST00000438926.2	+	5	692	c.663C>T	c.(661-663)ctC>ctT	p.L221L	SLC12A3_ENST00000566786.1_Silent_p.L220L|SLC12A3_ENST00000563236.1_Silent_p.L221L|SLC12A3_ENST00000262502.5_Silent_p.L220L	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	221					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CCATCGGCCTCATTTTCGCTT	0.637000													34	95					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47660785	47660785	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr21:47660785T>A	ENST00000397708.1	-	27	5827	c.5573A>T	c.(5572-5574)gAg>gTg	p.E1858V	MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000588753.1_RNA|MCM3AP_ENST00000291688.1_Missense_Mutation_p.E1858V|MCM3AP-AS1_ENST00000591223.1_RNA|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP-AS1_ENST00000432735.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000421927.1_RNA|MCM3AP-AS1_ENST00000444998.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1858					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					CAAGAGCTCCTCAGCAGAAGC	0.517000													7	153					0	0	1	0	0
BCAS2	10286	broad.mit.edu	37	1	115110828	115110828	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:115110828G>A	ENST00000369541.3	-	7	648	c.601C>T	c.(601-603)Cag>Tag	p.Q201*	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	201					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTTCTAGCTGAACAATAGTC	0.368000													39	107					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70418920	70418920	+	Silent	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:70418920C>A	ENST00000381280.4	+	2	418	c.165C>A	c.(163-165)atC>atA	p.I55I	SMOC1_ENST00000555917.1_3'UTR|SMOC1_ENST00000361956.3_Silent_p.I55I	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	55	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CCAAACCCATCTGTGCCTCTG	0.537000													46	102					1.41504e-22	1.51829e-22	1	1	0
ADAM28	10863	broad.mit.edu	37	8	24207413	24207413	+	Missense_Mutation	SNP	C	C	T	rs139883608	by1000genomes	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:24207413C>T	ENST00000265769.4	+	19	2137	c.2027C>T	c.(2026-2028)gCg>gTg	p.A676V	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000397649.3_Silent_p.G424G|RP11-624C23.1_ENST00000518988.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	676					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding	p.A676V(1)		central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TTCCCAATGGCGGTCATTTTT	0.502000													41	140					0	0	1	0	0
SEC61A2	55176	broad.mit.edu	37	10	12191690	12191690	+	Missense_Mutation	SNP	C	C	T	rs146484607		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:12191690C>T	ENST00000379033.3	+	4	398	c.251C>T	c.(250-252)cCg>cTg	p.P84L	SEC61A2_ENST00000379020.4_Missense_Mutation_p.P106L|SEC61A2_ENST00000495368.1_3'UTR|SEC61A2_ENST00000379017.3_Missense_Mutation_p.P106L|SEC61A2_ENST00000304267.8_Missense_Mutation_p.P106L|SEC61A2_ENST00000379051.1_Missense_Mutation_p.P106L|SEC61A2_ENST00000298428.9_Missense_Mutation_p.P106L	NM_001142628.1	NP_001136100.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	106						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				GGAGATACACCGAAAGATAGA	0.393000													18	87					0	0	1	0	0
MCU	90550	broad.mit.edu	37	10	74620268	74620268	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:74620268T>C	ENST00000536019.1	+	4	777	c.332T>C	c.(331-333)gTa>gCa	p.V111A	MCU_ENST00000357157.6_Missense_Mutation_p.V160A|MCU_ENST00000373053.3_Missense_Mutation_p.V160A	NM_001270680.1	NP_001257609.1	Q8NE86	MCU_HUMAN	mitochondrial calcium uniporter	160					elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	14						ACATACCACGTACGACCACCA	0.398000													25	59					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10447434	10447434	+	Silent	SNP	C	C	T	rs111972960		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:10447434C>T	ENST00000326756.3	-	3	957	c.519G>A	c.(517-519)acG>acA	p.T173T		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ACTCTCCTTTCGTATACGAAA	0.398000													4	132					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47660829	47660829	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr21:47660829C>T	ENST00000397708.1	-	27	5783	c.5529G>A	c.(5527-5529)ggG>ggA	p.G1843G	MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000588753.1_RNA|MCM3AP_ENST00000291688.1_Silent_p.G1843G|MCM3AP-AS1_ENST00000591223.1_RNA|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP-AS1_ENST00000432735.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000421927.1_RNA|MCM3AP-AS1_ENST00000444998.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1843					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TGGGAATCCTCCCCTCTTGAG	0.502000													5	163					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78062034	78062034	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:78062034A>G	ENST00000299642.4	+	2	258	c.173A>G	c.(172-174)gAa>gGa	p.E58G	CLEC3A_ENST00000575655.1_Missense_Mutation_p.E49G|RP11-281J9.2_ENST00000563114.1_RNA	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	49					skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						ACTCAAATTGAAAAGCTCTGG	0.438000													31	70					0	0	1	0	0
ARMCX6	54470	broad.mit.edu	37	X	100871295	100871295	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:100871295G>C	ENST00000539247.1	-	4	748	c.316C>G	c.(316-318)Ccc>Gcc	p.P106A	ARMCX6_ENST00000361910.4_Missense_Mutation_p.P106A|ARMCX6_ENST00000538627.1_Missense_Mutation_p.P106A|ARMCX6_ENST00000497931.1_Intron	NM_001184768.1	NP_001171697.1	Q7L4S7	ARMX6_HUMAN	armadillo repeat containing, X-linked 6	106						integral to membrane				endometrium(3)|kidney(1)|liver(2)|lung(3)	9						TGTTCATAGGGGAATGGCCGC	0.502000													7	118					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63662785	63662785	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:63662785C>T	ENST00000402010.2	+	2	788	c.209C>T	c.(208-210)gCc>gTc	p.A70V	MARK2_ENST00000408948.3_Missense_Mutation_p.A37V|MARK2_ENST00000425897.2_Missense_Mutation_p.A37V|MARK2_ENST00000413835.2_Missense_Mutation_p.A70V|MARK2_ENST00000502399.3_Missense_Mutation_p.A70V|MARK2_ENST00000350490.7_Missense_Mutation_p.A70V|MARK2_ENST00000361128.5_Missense_Mutation_p.A70V|MARK2_ENST00000315032.8_Missense_Mutation_p.A70V|MARK2_ENST00000377810.3_Missense_Mutation_p.A37V|MARK2_ENST00000513765.2_Missense_Mutation_p.A37V|MARK2_ENST00000377809.4_Missense_Mutation_p.A70V|MARK2_ENST00000509502.2_Missense_Mutation_p.A37V|MARK2_ENST00000508192.1_Missense_Mutation_p.A70V	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	70	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						GTGAAGTTGGCCCGACACATC	0.577000													4	98					0	0	1	0	0
AMIGO3	386724	broad.mit.edu	37	3	49755598	49755598	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:49755598G>A	ENST00000535833.1	-	10	4751	c.1301C>T	c.(1300-1302)tCa>tTa	p.S434L	AMIGO3_ENST00000320431.7_Missense_Mutation_p.S434L|RNF123_ENST00000497099.1_3'UTR|GMPPB_ENST00000480687.1_3'UTR|RNF123_ENST00000327697.6_Intron|RNF123_ENST00000433785.1_Intron			Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	434					heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCTGAGTACTGAGGACTGTGC	0.692000													8	233					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160134055	160134055	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:160134055C>T	ENST00000368081.4	+	7	1359	c.888C>T	c.(886-888)atC>atT	p.I296I		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	296					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.I296I(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGCTGAGATCGAACACTTCA	0.542000													10	185					0	0	1	0	0
TCP11L1	55346	broad.mit.edu	37	11	33076194	33076194	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:33076194C>T	ENST00000334274.4	+	3	619	c.219C>T	c.(217-219)gtC>gtT	p.V73V	TCP11L1_ENST00000432887.1_Silent_p.V73V|TCP11L1_ENST00000530171.1_Intron|TCP11L1_ENST00000531632.2_Silent_p.V73V	NM_018393.3	NP_060863.3	Q9NUJ3	T11L1_HUMAN	t-complex 11, testis-specific-like 1	73										kidney(1)|liver(2)|lung(2)|skin(1)	6						CGAGAGGTGTCACCAACATGG	0.418000													37	101					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	408579	408579	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:408579G>T	ENST00000280886.6	-	22	2732	c.2645C>A	c.(2644-2646)gCa>gAa	p.A882E	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Missense_Mutation_p.A203E	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	882						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GAGGGTGTTTGCTGGCACCAA	0.443000													18	70					1.33834e-09	1.40561e-09	1	1	0
MCM3AP	8888	broad.mit.edu	37	21	47660786	47660786	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr21:47660786C>T	ENST00000397708.1	-	27	5826	c.5572G>A	c.(5572-5574)Gag>Aag	p.E1858K	MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000588753.1_RNA|MCM3AP_ENST00000291688.1_Missense_Mutation_p.E1858K|MCM3AP-AS1_ENST00000591223.1_RNA|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP-AS1_ENST00000432735.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000421927.1_RNA|MCM3AP-AS1_ENST00000444998.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1858					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					AAGAGCTCCTCAGCAGAAGCT	0.512000													7	153					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33373367	33373367	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:33373367C>T	ENST00000303296.4	+	15	3326	c.3021C>T	c.(3019-3021)gcC>gcT	p.A1007A	HIPK3_ENST00000379016.3_Silent_p.A986A|HIPK3_ENST00000525975.1_Silent_p.A986A|HIPK3_ENST00000456517.1_Silent_p.A986A	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	1007	Required for localization to nuclear speckles (By similarity).				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						GCTTAAATGCCGATGAGCATA	0.433000													7	32					0	0	1	0	0
PAK1	5058	broad.mit.edu	37	11	77091019	77091019	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:77091019C>G	ENST00000356341.3	-	3	742	c.211G>C	c.(211-213)Gag>Cag	p.E71Q	PAK1_ENST00000530617.1_Missense_Mutation_p.E71Q|PAK1_ENST00000528203.1_5'UTR|PAK1_ENST00000278568.4_Missense_Mutation_p.E71Q	NM_002576.4	NP_002567.3	Q13153	PAK1_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 1	71	Autoregulatory region.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(13)|skin(2)|stomach(1)	29	all_cancers(14;1.75e-18)					TCTGGCCGCTCTTTCTCTTTC	0.388000													4	61					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949845	27949845	+	Silent	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:27949845C>G	ENST00000379992.2	-	6	1274	c.825G>C	c.(823-825)ctG>ctC	p.L275L	LINGO2_ENST00000308675.3_Silent_p.L275L	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	275						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TAAGGTGAGTCAGGTATACCA	0.502000													29	176					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118770865	118770865	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:118770865G>A	ENST00000334801.3	-	7	4131	c.3167C>T	c.(3166-3168)cCt>cTt	p.P1056L	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1056	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GTTGGCGGGAGGTGCTGAGGA	0.632000													16	57					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7218340	7218340	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:7218340G>C	ENST00000380728.2	-	2	332	c.32C>G	c.(31-33)tCc>tGc	p.S11C	GPS2_ENST00000391950.3_Missense_Mutation_p.S11C|GPS2_ENST00000389167.5_Missense_Mutation_p.S11C|RP11-542C16.2_ENST00000575474.1_3'UTR			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	11					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				CATGGCGTTGGAAAGCTTGGG	0.711000											OREG0006475	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=GPS2|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	4	10					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32052762	32052762	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:32052762C>G	ENST00000438447.1	+	9	2099	c.1711C>G	c.(1711-1713)Cag>Gag	p.Q571E	PDZD2_ENST00000282493.3_Missense_Mutation_p.Q571E			O15018	PDZD2_HUMAN	PDZ domain containing 2	571					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AAGCACGACTCAGGTGGAATC	0.463000													8	159					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132529947	132529947	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:132529947C>T	ENST00000333577.4	+	39	7085	c.6976C>T	c.(6976-6978)Ctg>Ttg	p.L2326L	EP400_ENST00000332482.4_Silent_p.L2253L|EP400_ENST00000389562.2_Silent_p.L2289L|EP400_ENST00000389561.2_Silent_p.L2290L|EP400_ENST00000330386.6_Silent_p.L2209L			Q96L91	EP400_HUMAN	E1A binding protein p400	2326					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ACCAGGACTTCTGAAAATTCG	0.572000													15	35					0	0	1	0	0
SNX18	112574	broad.mit.edu	37	5	53815305	53815305	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:53815305C>T	ENST00000343017.6	+	1	1717	c.1523C>T	c.(1522-1524)gCg>gTg	p.A508V	SNX18_ENST00000381410.4_Missense_Mutation_p.A508V|SNX18_ENST00000326277.3_Missense_Mutation_p.A508V	NM_001145427.1	NP_001138899.1	Q96RF0	SNX18_HUMAN	sorting nexin 18	508	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding			endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	18		Lung NSC(810;3.46e-05)|Breast(144;0.102)				GAGCTCTTCGCGGAGCAGCCC	0.597000													4	130					0	0	1	0	0
SZRD1	26099	broad.mit.edu	37	1	16719858	16719858	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:16719858C>T	ENST00000401088.4	+	3	412	c.237C>T	c.(235-237)agC>agT	p.S79S	SZRD1_ENST00000471507.1_Silent_p.S78S|SZRD1_ENST00000472461.1_3'UTR|SZRD1_ENST00000492354.1_Silent_p.S59S|SZRD1_ENST00000375590.3_Silent_p.S59S|SZRD1_ENST00000401089.3_Silent_p.S60S	NM_001114600.1|NM_001271869.1	NP_001108072.1|NP_001258798.1			SUZ RNA binding domain containing 1																		ACTCCACCAGCAGGCCCACCC	0.672000													44	101					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156520136	156520136	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:156520136C>T	ENST00000361170.2	-	16	1752	c.1742G>A	c.(1741-1743)gGg>gAg	p.G581E		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	581					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCCAGGATCCCCTGTCACCTG	0.537000													14	27					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11752727	11752727	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:11752727C>T	ENST00000381486.2	+	19	3413	c.3113C>T	c.(3112-3114)tCc>tTc	p.S1038F	GREB1_ENST00000234142.5_Missense_Mutation_p.S1038F|GREB1_ENST00000396123.1_Missense_Mutation_p.S36F	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1038						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CATGGGGAGTCCTTGCCGAGG	0.617000													18	63					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101829594	101829594	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:101829594C>T	ENST00000370418.3	-	3	704	c.453G>A	c.(451-453)agG>agA	p.R151R		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	151	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TTGCATTGTTCCTGCCAACTA	0.418000													24	68					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223987650	223987650	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:223987650C>T	ENST00000391878.2	-	12	1817	c.1049G>A	c.(1048-1050)gGt>gAt	p.G350D	TP53BP2_ENST00000391879.2_5'UTR|TP53BP2_ENST00000343537.7_Missense_Mutation_p.G479D|TP53BP2_ENST00000498843.1_5'UTR	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	473					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		CCTCAGAGTACCAAAGGAAGG	0.433000													10	54					0	0	1	0	0
FAM115C	285966	broad.mit.edu	37	7	143421718	143421718	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:143421718C>G	ENST00000441159.2	+	7	2499	c.2433C>G	c.(2431-2433)atC>atG	p.I811M	FAM115C_ENST00000411497.2_Missense_Mutation_p.I530M|FAM115C_ENST00000411935.1_Missense_Mutation_p.I707M|FAM115C_ENST00000444908.2_Missense_Mutation_p.I811M|FAM115C_ENST00000425618.2_Missense_Mutation_p.I530M|FAM115C_ENST00000409703.3_Missense_Mutation_p.I707M|FAM115C_ENST00000357344.4_Missense_Mutation_p.I811M			A6NFQ2	F115C_HUMAN	family with sequence similarity 115, member C	811										endometrium(2)|large_intestine(4)|lung(2)|prostate(1)	9						AGAGGAGAATCAAGGCCCACC	0.567000													12	47					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38176142	38176142	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:38176142C>T	ENST00000394126.1	-	24	3242	c.2824G>A	c.(2824-2826)Gct>Act	p.A942T	MED24_ENST00000394128.2_Missense_Mutation_p.A917T|MED24_ENST00000356271.3_Missense_Mutation_p.A904T|MED24_ENST00000394127.2_Missense_Mutation_p.A904T|MED24_ENST00000501516.3_Missense_Mutation_p.A936T			O75448	MED24_HUMAN	mediator complex subunit 24	917					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					TGGGGGCCAGCGGTGCGAGAC	0.622000													4	2					0	0	1	0	0
SAE1	10055	broad.mit.edu	37	19	47656163	47656163	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:47656163G>C	ENST00000413379.3	+	4	495	c.393G>C	c.(391-393)ctG>ctC	p.L131L	SAE1_ENST00000598840.1_Intron|SAE1_ENST00000540850.1_Intron|SAE1_ENST00000392776.3_Silent_p.L131L|SAE1_ENST00000270225.7_Silent_p.L131L	NM_001145713.1	NP_001139185.1	Q9UBE0	SAE1_HUMAN	SUMO1 activating enzyme subunit 1	131					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			endometrium(3)|large_intestine(5)|lung(4)|ovary(1)	13		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		AGGTGTGTCTGACTTGCTGCT	0.398000													7	189					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887527	12887527	+	Silent	SNP	A	A	G	rs2486716		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:12887527A>G	ENST00000535591.1	-	3	525	c.330T>C	c.(328-330)ttT>ttC	p.F110F		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	110								p.F110F(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						AAAGTTCTACAAACACAGTCA	0.498000													6	453					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169227642	169227642	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:169227642G>A	ENST00000393743.3	-	5	785	c.494C>T	c.(493-495)tCt>tTt	p.S165F		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	165							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CCTTGCCCAAGAATGAATGAT	0.413000													4	91					0	0	1	0	0
PLOD1	5351	broad.mit.edu	37	1	12017008	12017008	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:12017008G>A	ENST00000196061.4	+	7	705	c.678G>A	c.(676-678)gtG>gtA	p.V226V	PLOD1_ENST00000376369.3_Silent_p.V273V|PLOD1_ENST00000485046.1_3'UTR	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	226					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGGGCCATGTGAGAGCGAGGA	0.622000													38	86					0	0	1	0	0
DPH5	51611	broad.mit.edu	37	1	101467118	101467118	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:101467118G>A	ENST00000370109.3	-	5	507	c.395C>T	c.(394-396)tCt>tTt	p.S132F	DPH5_ENST00000342173.7_Missense_Mutation_p.S132F|DPH5_ENST00000488176.1_Missense_Mutation_p.S132F|DPH5_ENST00000370105.3_5'UTR	NM_001077394.1|NM_001077395.1|NM_015958.2	NP_001070862.1|NP_001070863.1|NP_057042.2	Q9H2P9	DPH5_HUMAN	diphthamide biosynthesis 5	132					peptidyl-diphthamide biosynthetic process from peptidyl-histidine		diphthine synthase activity			endometrium(2)|large_intestine(1)|lung(4)	7		all_epithelial(167;3.1e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0385)|all cancers(265;0.043)|COAD - Colon adenocarcinoma(174;0.151)|Colorectal(144;0.173)|Lung(183;0.198)		AAAAACAATAGAAACTGTCTC	0.303000													7	25					0	0	1	0	0
RIN1	9610	broad.mit.edu	37	11	66102902	66102902	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:66102902C>G	ENST00000311320.4	-	5	649	c.523G>C	c.(523-525)Gag>Cag	p.E175Q	RIN1_ENST00000530056.1_Missense_Mutation_p.E70Q|RP11-867G23.12_ENST00000526655.1_RNA|RIN1_ENST00000424433.2_Missense_Mutation_p.E70Q	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	175					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						GAGATGGCCTCCAGCTCTTTG	0.622000													12	43					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7244099	7244099	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:7244099G>A	ENST00000542285.1	-	2	326	c.177C>T	c.(175-177)ttC>ttT	p.F59F				P00736	C1R_HUMAN	complement component 1, r subcomponent	60	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAAACTGCTGGAAGACGAGCT	0.557000													10	16					0	0	1	0	0
ATG4D	84971	broad.mit.edu	37	19	10663612	10663612	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:10663612G>A	ENST00000309469.4	+	10	1467	c.1294G>A	c.(1294-1296)Gag>Aag	p.E432K	ATG4D_ENST00000540862.1_Missense_Mutation_p.E99K	NM_032885.4	NP_116274.3	Q86TL0	ATG4D_HUMAN	autophagy related 4D, cysteine peptidase	432					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity	p.E432K(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	19			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CACCCTGGCCGAGGGCCATGC	0.662000													5	120					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213405586	213405586	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:213405586C>A	ENST00000366960.3	+	10	1363	c.1213C>A	c.(1213-1215)Cag>Aag	p.Q405K	RPS6KC1_ENST00000543354.1_Missense_Mutation_p.Q108K|RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000543470.1_Missense_Mutation_p.Q193K|RPS6KC1_ENST00000366959.3_Missense_Mutation_p.Q393K	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	405	Protein kinase 1.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TCTTGTGCTGCAGCATGCGGA	0.448000													42	175					4.18559e-23	4.50319e-23	1	1	0
GOLGB1	2804	broad.mit.edu	37	3	121413052	121413052	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:121413052C>G	ENST00000393667.3	-	13	6428	c.6318G>C	c.(6316-6318)ttG>ttC	p.L2106F	GOLGB1_ENST00000340645.5_Missense_Mutation_p.L2101F	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2101					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		GTTCCTTTTTCAACTTGAGAT	0.423000													5	171					0	0	1	0	0
P4HA1	5033	broad.mit.edu	37	10	74831832	74831832	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:74831832C>A	ENST00000412021.2	-	5	613	c.280G>T	c.(280-282)Gag>Tag	p.E94*	P4HA1_ENST00000394890.2_Nonsense_Mutation_p.E94*|P4HA1_ENST00000440381.1_Nonsense_Mutation_p.E94*|P4HA1_ENST00000307116.2_Nonsense_Mutation_p.E94*|P4HA1_ENST00000263556.3_Nonsense_Mutation_p.E94*|P4HA1_ENST00000373008.2_Nonsense_Mutation_p.E94*|RP11-344N10.2_ENST00000431293.2_RNA	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	94						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCACTCCACTCAGTATTCAGA	0.388000													38	156					4.0492e-12	4.29821e-12	1	1	0
GIGYF2	26058	broad.mit.edu	37	2	233651923	233651923	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:233651923C>G	ENST00000373566.3	+	10	859	c.662C>G	c.(661-663)tCa>tGa	p.S221*	GIGYF2_ENST00000409547.1_Nonsense_Mutation_p.S199*|GIGYF2_ENST00000409451.3_Nonsense_Mutation_p.S221*|GIGYF2_ENST00000373563.4_Nonsense_Mutation_p.S199*|GIGYF2_ENST00000452341.2_Nonsense_Mutation_p.S30*|GIGYF2_ENST00000409480.1_Nonsense_Mutation_p.S221*|GIGYF2_ENST00000409196.3_Nonsense_Mutation_p.S199*			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	199	Arg-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TTTATACGCTCAGAAAGTGAA	0.423000													29	38					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563543	55563543	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:55563543C>G	ENST00000335605.1	+	1	512	c.512C>G	c.(511-513)tCt>tGt	p.S171C		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S171Y(1)|p.S171F(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				TTAAACTTCTCTGGACCTAAT	0.493000													8	221					0	0	1	0	0
RPS6KB1	6198	broad.mit.edu	37	17	58013586	58013586	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:58013586G>C	ENST00000225577.4	+	11	1010	c.989G>C	c.(988-990)aGa>aCa	p.R330T	RPS6KB1_ENST00000406116.3_Missense_Mutation_p.R330T|RPS6KB1_ENST00000443572.2_Missense_Mutation_p.R307T|RPS6KB1_ENST00000393021.3_Missense_Mutation_p.R277T	NM_001272042.1|NM_001272044.1|NM_001272060.1|NM_003161.2	NP_001258971.1|NP_001258973.1|NP_001258989.1|NP_003152.1	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 1	330	Protein kinase.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			CTGCTGAAAAGAAATGCTGCT	0.408000													22	76					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25264737	25264737	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:25264737C>T	ENST00000400358.4	+	12	1263	c.1206C>T	c.(1204-1206)gcC>gcT	p.A402A	SGSM1_ENST00000400359.4_Silent_p.A402A	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	402						Golgi apparatus	Rab GTPase activator activity	p.A402A(2)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						AGGGTTCTGCCGAGTCCACAT	0.517000													4	149					0	0	1	0	0
SLC6A7	6534	broad.mit.edu	37	5	149582169	149582169	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:149582169C>T	ENST00000230671.2	+	8	1361	c.990C>T	c.(988-990)aaC>aaT	p.N330N	SLC6A7_ENST00000524041.1_Silent_p.N330N	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	330						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity	p.N330N(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	CTCTGGGCAACGCCATCACCA	0.602000													35	84					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53352349	53352349	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:53352349C>T	ENST00000595646.1	-	3	253	c.133G>A	c.(133-135)Gtc>Atc	p.V45I	ZNF468_ENST00000390651.4_5'UTR|ZNF468_ENST00000243639.4_Missense_Mutation_p.V45I|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000396409.4_5'UTR			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.V45I(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		CCCAGGGAGACGAGGTTCCTA	0.483000													43	268					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6753358	6753358	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:6753358C>T	ENST00000229243.2	-	5	982	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K	ACRBP_ENST00000536350.1_Missense_Mutation_p.E297K|ACRBP_ENST00000414226.2_Missense_Mutation_p.E264K	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	297						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						TCATTCATTTCATCTATTTCC	0.458000													43	76					0	0	1	0	0
NUBP2	10101	broad.mit.edu	37	16	1837974	1837974	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:1837974G>A	ENST00000262302.9	+	5	642	c.522G>A	c.(520-522)ctG>ctA	p.L174L	NUBP2_ENST00000568706.1_Silent_p.L33L|NUBP2_ENST00000543305.1_Silent_p.L33L|NUBP2_ENST00000565987.1_Silent_p.L114L|NUBP2_ENST00000565134.1_Silent_p.L174L	NM_012225.2	NP_036357.1	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2	174						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						GGCGCGAGCTGACCTTCTGTA	0.682000													29	106					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152287145	152287145	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:152287145C>G	ENST00000368799.1	-	3	252	c.217G>C	c.(217-219)Gag>Cag	p.E73Q	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	73	EF-hand 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGAAGAAACTCAGTGAAGTCA	0.403000									Ichthyosis				19	61					0	0	1	0	0
REL	5966	broad.mit.edu	37	2	61118956	61118956	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:61118956T>C	ENST00000295025.7	+	2	469	c.149T>C	c.(148-150)aTc>aCc	p.I50T	REL_ENST00000394479.3_Missense_Mutation_p.I50T	NM_002908.2	NP_002899.1	Q04864	REL_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog	50	RHD.				positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(3)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	16	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			TACCCTTCTATCCAGGTAATA	0.438000			A		Hodgkin Lymphoma								22	55					0	0	1	0	0
ATXN3	4287	broad.mit.edu	37	14	92572896	92572896	+	Translation_Start_Site	SNP	T	T	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:92572896T>C	ENST00000545170.1	-	1	69	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	ATXN3_ENST00000429774.2_Start_Codon_SNP_p.M1V|ATXN3_ENST00000502250.1_5'UTR|ATXN3_ENST00000554491.1_5'UTR|ATXN3_ENST00000532032.1_Start_Codon_SNP_p.M1V|ATXN3_ENST00000340660.6_Start_Codon_SNP_p.M1V|ATXN3_ENST00000393287.5_Start_Codon_SNP_p.M1V|ATXN3_ENST00000503767.1_Start_Codon_SNP_p.M1V	NM_001164774.1|NM_001164776.1|NM_001164777.1|NM_001164778.1|NM_004993.5	NP_001158246.1|NP_001158248.1|NP_001158249.1|NP_001158250.1|NP_004984.2	P54252	ATX3_HUMAN	ataxin 3	1	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding			endometrium(2)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	12		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		ATGGACTCCATGTTTATTTGT	0.711000													18	56					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7216782	7216782	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:7216782G>A	ENST00000380728.2	-	8	941	c.641C>T	c.(640-642)tCg>tTg	p.S214L	GPS2_ENST00000391950.3_Missense_Mutation_p.S214L|GPS2_ENST00000389167.5_Missense_Mutation_p.S214L|RP11-542C16.2_ENST00000575474.1_3'UTR			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	214					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				AGGGAATGCCGAAGGAGCTGA	0.507000											OREG0024133	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	94					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75264827	75264827	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:75264827C>G	ENST00000325680.7	+	5	2951	c.2827C>G	c.(2827-2829)Cag>Gag	p.Q943E	YLPM1_ENST00000238571.3_Missense_Mutation_p.Q748E|YLPM1_ENST00000552421.1_Intron	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	748	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGCTGTTACTCAGCCTGTACC	0.478000													35	56					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26387823	26387823	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:26387823C>T	ENST00000374272.3	-	3	473	c.335G>A	c.(334-336)cGg>cAg	p.R112Q	TRIM63_ENST00000483052.1_5'UTR	NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	112	Interaction with TTN.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCAGCGGCCGACTGCAGTG	0.592000													19	34					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8088840	8088840	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr18:8088840C>A	ENST00000332175.8	+	11	2884	c.1847C>A	c.(1846-1848)gCa>gAa	p.A616E	PTPRM_ENST00000400060.4_Missense_Mutation_p.A616E|PTPRM_ENST00000400053.4_Missense_Mutation_p.A554E|PTPRM_ENST00000444013.1_Missense_Mutation_p.A403E|PTPRM_ENST00000578571.1_3'UTR|PTPRM_ENST00000580170.1_Missense_Mutation_p.A616E	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	616	Fibronectin type-III 4.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				AGCAGAGGAGCACCTGTCAGG	0.468000													22	53					0.000175454	0.000178603	1	1	0
HYAL1	3373	broad.mit.edu	37	3	50339662	50339662	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:50339662G>A	ENST00000266031.4	-	1	1341	c.726C>T	c.(724-726)ctC>ctT	p.L242L	HYAL1_ENST00000395143.2_Silent_p.L242L|HYAL1_ENST00000395144.2_Silent_p.L242L|HYAL1_ENST00000447605.2_Intron|HYAL1_ENST00000457214.2_Silent_p.L60L|HYAL1_ENST00000320295.8_Silent_p.L242L			Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1	242						extracellular space|lysosome	hyalurononglucosaminidase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	TGCTGGGATAGAGGGCACGGC	0.597000													20	62					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32364031	32364031	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:32364031T>G	ENST00000454136.3	-	5	867	c.863A>C	c.(862-864)tAc>tCc	p.Y288S	BTNL2_ENST00000374995.3_Missense_Mutation_p.Y194S|BTNL2_ENST00000429232.2_Missense_Mutation_p.Y195S|BTNL2_ENST00000414363.1_Missense_Mutation_p.Y78S|BTNL2_ENST00000544175.1_Missense_Mutation_p.Y11S|BTNL2_ENST00000540315.1_Missense_Mutation_p.Y78S|BTNL2_ENST00000374993.1_Missense_Mutation_p.Y288S			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	288	Ig-like V-type 3.					integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						CACAGCAGGGTAACGGTGGGA	0.552000													18	32					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107379601	107379601	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:107379601G>A	ENST00000259362.1	-	1	884	c.885C>T	c.(883-885)atC>atT	p.I295I		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						TAAGACTGTAGATTAAAGGAT	0.393000													45	176					0	0	1	0	0
SPPL2A	84888	broad.mit.edu	37	15	51041871	51041871	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:51041871G>A	ENST00000261854.5	-	2	413	c.139C>T	c.(139-141)Cct>Tct	p.P47S	RP11-507J18.2_ENST00000558317.1_RNA	NM_032802.3	NP_116191.2	Q8TCT8	PSL2_HUMAN	signal peptide peptidase like 2A	47						integral to membrane	aspartic-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		GTCCAATAAGGGTTATAAAGC	0.418000													5	151					0	0	1	0	0
ZNF252P	286101	broad.mit.edu	37	8	146220599	146220599	+	RNA	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:146220599G>A	ENST00000426361.2	-	0	245					NR_023392.1															endometrium(1)	1						AGTGTGTTTTGAGAGCAAGGA	0.403000													30	84					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48665936	48665936	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:48665936C>T	ENST00000358747.6	-	15	1918	c.1668G>A	c.(1666-1668)aaG>aaA	p.K556K	SLC26A6_ENST00000455886.2_Silent_p.K541K|SLC26A6_ENST00000395550.2_Silent_p.K577K|SLC26A6_ENST00000337000.8_Silent_p.K470K|SLC26A6_ENST00000420764.2_Silent_p.K577K|SLC26A6_ENST00000383733.3_Silent_p.K577K	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		TGAGCAGTTTCTTCTTCTGGG	0.552000													7	150					0	0	1	0	0
INTS6-AS1	100507398	broad.mit.edu	37	13	52035183	52035183	+	RNA	SNP	A	A	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:52035183A>G	ENST00000594959.1	+	0	411				INTS6-AS1_ENST00000595997.1_RNA|INTS6-AS1_ENST00000593429.1_RNA|INTS6-AS1_ENST00000602089.1_RNA|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000601572.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000601318.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|RPS4XP16_ENST00000595905.1_RNA|INTS6-AS1_ENST00000601034.1_RNA|INTS6-AS1_ENST00000597745.1_RNA|INTS6-AS1_ENST00000594604.1_RNA|INTS6-AS1_ENST00000594488.1_RNA|INTS6-AS1_ENST00000599315.1_RNA|INTS6-AS1_ENST00000598864.1_RNA|INTS6-AS1_ENST00000594358.1_RNA|INTS6-AS1_ENST00000600477.1_RNA|INTS6-AS1_ENST00000593928.1_RNA|INTS6-AS1_ENST00000593709.1_RNA|INTS6-AS1_ENST00000596303.1_RNA|INTS6-AS1_ENST00000434512.1_RNA|INTS6-AS1_ENST00000596180.1_RNA																							ATTTCATCAAATTCGACACTG	0.463000													4	37					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100675301	100675301	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:100675301G>A	ENST00000306151.4	+	3	668	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	202	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACTACTCCTGAAAGCACCAC	0.458000													10	305					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58601584	58601584	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:58601584C>T	ENST00000240727.6	-	2	450	c.51G>A	c.(49-51)ccG>ccA	p.P17P	ZSCAN18_ENST00000421612.2_Intron|ZSCAN18_ENST00000600404.1_Silent_p.P73P|ZSCAN18_ENST00000601144.1_Silent_p.P17P	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	17					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCAGATCCGGCGGGGCTGGGG	0.627000													40	94					0	0	1	0	0
SPIN4	139886	broad.mit.edu	37	X	62570369	62570369	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:62570369G>C	ENST00000374884.2	-	1	854	c.276C>G	c.(274-276)atC>atG	p.I92M	SPIN4_ENST00000335144.3_Missense_Mutation_p.I110M|SPIN4-AS1_ENST00000451979.1_RNA			Q56A73	SPIN4_HUMAN	spindlin family, member 4	110					gamete generation					endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	11						GTCGTGAATCGATACGAGGAG	0.488000													3	36					0	0	1	0	0
RBBP7	5931	broad.mit.edu	37	X	16887263	16887263	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:16887263G>C	ENST00000380087.2	-	2	457	c.97C>G	c.(97-99)Ctg>Gtg	p.L33V	RBBP7_ENST00000380084.4_Missense_Mutation_p.L77V|RBBP7_ENST00000404022.1_Missense_Mutation_p.L33V			Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	33					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			biliary_tract(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	25	Hepatocellular(33;0.0997)					GTCATAACCAGGTCATATAGA	0.403000													38	24					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													4	74					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100537776	100537776	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:100537776C>A	ENST00000268070.4	-	19	2715	c.2610G>T	c.(2608-2610)tgG>tgT	p.W870C		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	870	TSP type-1 3.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		AGCAGGGGCTCCACGGGCCTG	0.667000													36	65					1.04594e-18	1.11623e-18	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22155264	22155264	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:22155264C>T	ENST00000397126.4	-	4	2720	c.2572G>A	c.(2572-2574)Gag>Aag	p.E858K	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAGGGTTTCTCTCCAGTATGA	0.378000													4	82					0	0	1	0	0
AGTRAP	57085	broad.mit.edu	37	1	11807587	11807587	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:11807587C>T	ENST00000376637.3	+	2	243	c.118C>T	c.(118-120)Cga>Tga	p.R40*	AGTRAP_ENST00000376627.2_Nonsense_Mutation_p.R96*|AGTRAP_ENST00000376629.4_Silent_p.I51I|AGTRAP_ENST00000510878.1_Intron|AGTRAP_ENST00000491346.1_3'UTR|AGTRAP_ENST00000452018.2_Nonsense_Mutation_p.R84*|AGTRAP_ENST00000400895.2_Nonsense_Mutation_p.R84*|AGTRAP_ENST00000314340.5_Silent_p.I51I	NM_001040195.1	NP_001035285.1	Q6RW13	ATRAP_HUMAN	angiotensin II receptor-associated protein	0						cytoplasmic vesicle membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding		AGTRAP/BRAF(2)	endometrium(1)|lung(3)|prostate(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.46e-06)|COAD - Colon adenocarcinoma(227;0.000256)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACTCCATCGACGCCATAA	0.637000													51	126					0	0	1	0	0
OR51B6	390058	broad.mit.edu	37	11	5373015	5373015	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:5373015G>C	ENST00000380219.1	+	1	278	c.278G>C	c.(277-279)gGa>gCa	p.G93A	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron	NM_001004750.1	NP_001004750.1	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B, member 6	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	21		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTGGCCATGGAGCCTGCTTC	0.488000													32	59					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103544224	103544224	+	Missense_Mutation	SNP	C	C	T	rs146954848		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:103544224C>T	ENST00000358392.2	-	3	795	c.478G>A	c.(478-480)Gct>Act	p.A160T	COL11A1_ENST00000512756.1_Missense_Mutation_p.A160T|COL11A1_ENST00000370096.3_Missense_Mutation_p.A160T|COL11A1_ENST00000353414.4_Missense_Mutation_p.A160T	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	160	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCCCGTCAGCGATGTTAACA	0.368000													15	52					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135272678	135272678	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:135272678C>T	ENST00000285968.6	+	10	1437	c.1411C>T	c.(1411-1413)Cag>Tag	p.Q471*	NUP205_ENST00000440390.2_Intron	NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	471					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AGAGCCTCTTCAGACTCCGAC	0.468000													14	66					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69733177	69733177	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:69733177G>A	ENST00000260363.4	+	18	2255	c.2138G>A	c.(2137-2139)cGc>cAc	p.R713H	KIF23_ENST00000352331.4_Intron|KIF23_ENST00000559279.1_Intron|KIF23_ENST00000558585.1_Intron|KIF23_ENST00000537891.1_Intron|KIF23_ENST00000395392.2_Missense_Mutation_p.R713H	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	713					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						CTACATAGGCGCTCTAACTCT	0.423000													18	31					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155167839	155167839	+	Silent	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:155167839G>T	ENST00000368378.3	-	18	2267	c.2247C>A	c.(2245-2247)ctC>ctA	p.L749L	THBS3_ENST00000541576.1_Silent_p.L146L|THBS3_ENST00000457183.2_Silent_p.L629L|RP11-263K19.4_ENST00000447623.1_RNA|THBS3_ENST00000428962.2_3'UTR|THBS3_ENST00000487250.1_5'UTR|THBS3_ENST00000541990.1_Silent_p.L278L	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	749	TSP C-terminal.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TTACCTGGTTGAGCACAACCC	0.572000													19	45					3.32936e-07	3.45106e-07	1	1	0
SIM1	6492	broad.mit.edu	37	6	100838258	100838258	+	Silent	SNP	A	A	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:100838258A>T	ENST00000369208.3	-	12	3062	c.2280T>A	c.(2278-2280)gtT>gtA	p.V760V	SIM1_ENST00000262901.4_Silent_p.V760V			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	760	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGGTTATTATAACAGATGTTC	0.378000													25	108					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													13	28					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47454793	47454793	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:47454793A>T	ENST00000398879.1	-	11	851	c.485T>A	c.(484-486)tTc>tAc	p.F162Y	TNS3_ENST00000311160.9_Missense_Mutation_p.F162Y|TNS3_ENST00000442536.2_Missense_Mutation_p.F162Y|TNS3_ENST00000355730.3_Missense_Mutation_p.F162Y|TNS3_ENST00000458317.2_Missense_Mutation_p.F162Y			Q68CZ2	TENS3_HUMAN	tensin 3	162	Phosphatase tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CCCACTGAGGAACTGAACATA	0.532000													7	25					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36700207	36700207	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:36700207C>T	ENST00000255448.4	-	2	279	c.68G>A	c.(67-69)cGa>cAa	p.R23Q	DCLK1_ENST00000379892.4_Missense_Mutation_p.R23Q|DCLK1_ENST00000360631.3_Missense_Mutation_p.R23Q	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	23					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CCGCGACCCTCGGCTGTATCT	0.637000													57	105					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146720619	146720619	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:146720619C>T	ENST00000392299.2	+	8	2914	c.2444C>T	c.(2443-2445)aCt>aTt	p.T815I	GRM1_ENST00000355289.4_Missense_Mutation_p.T815I|GRM1_ENST00000492807.2_Missense_Mutation_p.T815I|GRM1_ENST00000361719.2_Missense_Mutation_p.T815I|GRM1_ENST00000507907.1_Missense_Mutation_p.T815I|GRM1_ENST00000282753.1_Missense_Mutation_p.T815I			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	815					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATCATCACAACTTGCTTTGCA	0.468000													28	66					0	0	1	0	0
CCR4	1233	broad.mit.edu	37	3	32995849	32995849	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:32995849G>A	ENST00000330953.5	+	2	1103	c.935G>A	c.(934-936)cGc>cAc	p.R312H		NM_005508.4	NP_005499.1	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	312					chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				NS(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)|stomach(1)	16						GAGAAATTTCGCAAGTACATC	0.478000													4	79					0	0	1	0	0
FAM78A	286336	broad.mit.edu	37	9	134151451	134151451	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:134151451G>A	ENST00000372271.3	-	1	483	c.116C>T	c.(115-117)aCg>aTg	p.T39M		NM_033387.3	NP_203745.2	Q5JUQ0	FA78A_HUMAN	family with sequence similarity 78, member A	39										NS(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		ATCAATCACCGTGATCCCTTC	0.602000													35	48					0	0	1	0	0
SULT2B1	6820	broad.mit.edu	37	19	49079249	49079249	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:49079249C>T	ENST00000323090.4	+	1	453	c.78C>T	c.(76-78)gtC>gtT	p.V26V	SULT2B1_ENST00000201586.2_Silent_p.V41V	NM_004605.2	NP_004596.2	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	41					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		CCTTCCCCGTCGGCCTGTACT	0.592000													6	144					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29611568	29611568	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:29611568G>A	ENST00000334018.6	+	3	456	c.268G>A	c.(268-270)Gcc>Acc	p.A90T	EMID1_ENST00000404820.3_Missense_Mutation_p.A90T|EMID1_ENST00000404755.3_Missense_Mutation_p.A90T|EMID1_ENST00000484039.1_3'UTR	NM_001267895.1|NM_133455.3	NP_001254824.1|NP_597712.2	Q96A84	EMID1_HUMAN	EMI domain containing 1	90	EMI.					collagen				NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						GATAGTGACCGCCCGTGAGTG	0.627000													22	65					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663145	34663145	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:34663145G>A	ENST00000488417.1	+	2	760	c.640G>A	c.(640-642)Gcc>Acc	p.A214T	C1orf94_ENST00000373374.3_Missense_Mutation_p.A24T	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	24							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				TCTGTGTGCCGCCGAGGTCAA	0.562000													22	79					0	0	1	0	0
USP22	23326	broad.mit.edu	37	17	20921341	20921341	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:20921341C>A	ENST00000261497.4	-	5	807	c.604G>T	c.(604-606)Gac>Tac	p.D202Y	USP22_ENST00000537526.2_Missense_Mutation_p.D190Y|USP22_ENST00000455117.2_Intron	NM_015276.1	NP_056091.1	Q9UPT9	UBP22_HUMAN	ubiquitin specific peptidase 22	202					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	15						AGGAAGAAGTCCCGCAGAAGT	0.567000													31	93					6.84511e-11	7.20825e-11	1	1	0
ANKRD12	23253	broad.mit.edu	37	18	9211769	9211769	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr18:9211769G>A	ENST00000383440.2	+	5	827	c.570G>A	c.(568-570)gtG>gtA	p.V190V	ANKRD12_ENST00000540578.2_3'UTR|ANKRD12_ENST00000400020.3_Silent_p.V190V|ANKRD12_ENST00000262126.3_Silent_p.V213V	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	213						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						ATGTGAATGTGAAAGATTTTG	0.323000													16	48					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12962069	12962069	+	Silent	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:12962069C>A	ENST00000273221.4	-	6	2139	c.1923G>T	c.(1921-1923)ggG>ggT	p.G641G		NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	641	SEC7.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCCGCACCACCCCAGGGTTGC	0.642000													4	136					0.150653	0.150653	1	1	0
IGDCC4	57722	broad.mit.edu	37	15	65680850	65680850	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:65680850C>G	ENST00000352385.2	-	16	2991	c.2782G>C	c.(2782-2784)Gag>Cag	p.E928Q		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	928	Fibronectin type-III 5.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GGTCCCACCTCTGTGCGCGCC	0.607000													72	184					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72241958	72241958	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:72241958G>C	ENST00000357731.4	-	3	671	c.432C>G	c.(430-432)atC>atG	p.I144M	NEGR1_ENST00000306821.3_Missense_Mutation_p.I16M|NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000434200.1_Missense_Mutation_p.I142M	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	144	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TATCATTTGAGATGTCATATA	0.368000													3	34					0	0	1	0	0
CABP1	9478	broad.mit.edu	37	12	121098056	121098056	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:121098056G>A	ENST00000453000.1	+	3	1063	c.551G>A	c.(550-552)cGg>cAg	p.R184Q	CABP1_ENST00000316803.3_Missense_Mutation_p.R248Q|CABP1_ENST00000351200.2_Missense_Mutation_p.R45Q|CABP1_ENST00000288616.3_Missense_Mutation_p.R105Q			Q9NZU7	CABP1_HUMAN	calcium binding protein 1	248						cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATCAACTGCCGGGATCTGGGC	0.567000													21	68					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	132052561	132052561	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:132052561G>A	ENST00000286355.5	-	1	2111	c.19C>T	c.(19-21)Cgc>Tgc	p.R7C	ADCY8_ENST00000377928.3_Missense_Mutation_p.R7C	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	7					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GTAAGGCAGCGCACATCGGAG	0.692000										HNSCC(32;0.087)			14	23					0	0	1	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107285	27107285	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:27107285G>A	ENST00000354348.2	+	1	210	c.198G>A	c.(196-198)gtG>gtA	p.V66V	HIST1H2BK_ENST00000396891.4_Intron	NM_003495.2	NP_003486.1	P62805	H4_HUMAN	histone cluster 1, H4i	66					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						TGGAGAACGTGATCCGGGACG	0.647000			T	BCL6	NHL								4	105					0	0	1	0	0
EZH2	2146	broad.mit.edu	37	7	148525892	148525892	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:148525892C>T	ENST00000320356.2	-	6	686	c.565G>A	c.(565-567)Gat>Aat	p.D189N	EZH2_ENST00000541220.1_Missense_Mutation_p.D180N|EZH2_ENST00000483967.1_Missense_Mutation_p.D180N|EZH2_ENST00000478654.1_Missense_Mutation_p.D180N|EZH2_ENST00000476773.1_Missense_Mutation_p.D180N|EZH2_ENST00000350995.2_Missense_Mutation_p.D150N|EZH2_ENST00000460911.1_Missense_Mutation_p.D189N|EZH2_ENST00000536783.1_Missense_Mutation_p.D80N	NM_001203247.1|NM_001203248.1|NM_004456.4	NP_001190176.1|NP_001190177.1|NP_004447.2	Q15910	EZH2_HUMAN	enhancer of zeste homolog 2 (Drosophila)	189	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(313)|kidney(3)|large_intestine(8)|liver(1)|lung(23)|parathyroid(2)|skin(3)|upper_aerodigestive_tract(3)	359	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TCGTCTCcatcatcatcatcg	0.393000			Mis		DLBCL								6	65					0	0	1	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73491066	73491066	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:73491066G>A	ENST00000556143.1	-	2	871	c.151C>T	c.(151-153)Cgg>Tgg	p.R51W	ZFYVE1_ENST00000553891.1_Missense_Mutation_p.R51W|ZFYVE1_ENST00000318876.5_Missense_Mutation_p.R51W	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	51						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		CGCTCCTGCCGATGGAGCTCC	0.552000													4	132					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230543	39230543	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:39230543C>T	ENST00000340369.3	-	2	622	c.394G>A	c.(394-396)Gaa>Aaa	p.E132K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E132K	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	132							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AAGGAGCCTTCCTCAAACTTG	0.602000													5	110					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46385781	46385781	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr18:46385781G>A	ENST00000256413.3	+	12	1943	c.1648G>A	c.(1648-1650)Gca>Aca	p.A550T	CTIF_ENST00000382998.4_Missense_Mutation_p.A552T	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	550	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						CCTGGCCAGCGCACGGGACAA	0.622000													42	109					0	0	1	0	0
SGSH	6448	broad.mit.edu	37	17	78184371	78184371	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:78184371C>T	ENST00000326317.6	-	8	1475	c.1389G>A	c.(1387-1389)atG>atA	p.M463I	SGSH_ENST00000534910.1_Missense_Mutation_p.M260I	NM_000199.3	NP_000190.1	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase	463					proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GGTCCCGAAGCATCTCCAGAA	0.687000													7	26					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67860551	67860551	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr18:67860551C>T	ENST00000255674.6	-	8	1266	c.980G>A	c.(979-981)gGc>gAc	p.G327D	RTTN_ENST00000437017.1_Missense_Mutation_p.G327D|RTTN_ENST00000454359.1_Missense_Mutation_p.G327D	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	327							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				CCAGTCCTGGCCATCTCCTCT	0.552000													14	44					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42911576	42911576	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:42911576C>T	ENST00000244289.4	-	6	2163	c.1887G>A	c.(1885-1887)cgG>cgA	p.R629R	LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000599276.1_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE_ENST00000602000.1_5'UTR	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	629					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				GCTCCAGGCTCCGTTGGCCGT	0.667000													15	45					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117704258	117704258	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:117704258C>T	ENST00000355044.3	+	29	4234	c.4108C>T	c.(4108-4110)Cac>Tac	p.H1370Y	ATRNL1_ENST00000303745.7_Missense_Mutation_p.H163Y|ATRNL1_ENST00000423111.2_Missense_Mutation_p.H421Y	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1370						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GAATCGAAAACACCTTTCAAC	0.418000													26	85					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102074293	102074293	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:102074293G>A	ENST00000369138.1	+	3	812	c.322G>A	c.(322-324)Ggg>Agg	p.G108R	GRIK2_ENST00000369137.3_Missense_Mutation_p.G108R|GRIK2_ENST00000421544.1_Missense_Mutation_p.G108R|GRIK2_ENST00000413795.1_Missense_Mutation_p.G108R|GRIK2_ENST00000369134.4_Missense_Mutation_p.G59R|GRIK2_ENST00000318991.6_Missense_Mutation_p.G108R|GRIK2_ENST00000358361.3_Missense_Mutation_p.G108R	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	108					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TGCCATCTTCGGGCCTTCACA	0.537000													5	305					0	0	1	0	0
ELK4	2005	broad.mit.edu	37	1	205589312	205589312	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:205589312G>A	ENST00000357992.4	-	3	1201	c.862C>T	c.(862-864)Cag>Tag	p.Q288*	ELK4_ENST00000289703.4_Nonsense_Mutation_p.Q288*	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TCCATTGGCTGAGAAGCCACT	0.453000			T	SLC45A3	prostate								5	222					0	0	1	0	0
TMEM161B	153396	broad.mit.edu	37	5	87516424	87516424	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:87516424C>G	ENST00000296595.6	-	5	526	c.402G>C	c.(400-402)atG>atC	p.M134I	TMEM161B_ENST00000514135.1_Missense_Mutation_p.M134I|TMEM161B_ENST00000511218.1_5'UTR|TMEM161B_ENST00000509387.1_Missense_Mutation_p.M7I|TMEM161B_ENST00000506536.1_5'UTR|TMEM161B_ENST00000512429.1_Missense_Mutation_p.M123I	NM_153354.3	NP_699185.1	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	134						integral to membrane				endometrium(4)|large_intestine(3)|lung(9)|skin(3)|upper_aerodigestive_tract(1)	20		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		AGCTGATATTCATTTCCTGTG	0.358000													15	44					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50722091	50722091	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:50722091C>G	ENST00000449103.1	-	15	2650	c.2510G>C	c.(2509-2511)aGg>aCg	p.R837T	PLXNB2_ENST00000496720.1_5'UTR|PLXNB2_ENST00000359337.4_Missense_Mutation_p.R837T			O15031	PLXB2_HUMAN	plexin B2	837	IPT/TIG 1.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CACAGAGATCCTCTGGATGTC	0.647000													18	46					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60695323	60695323	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:60695323C>G	ENST00000005286.4	+	3	679	c.526C>G	c.(526-528)Cgc>Ggc	p.R176G	TMEM132A_ENST00000453848.2_Missense_Mutation_p.R176G	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	176						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						CCAAGCCTGCCGCTTCCAGGT	0.672000													14	31					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730784	96730784	+	Silent	SNP	C	C	T	rs150459277		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:96730784C>T	ENST00000216629.6	+	3	1371	c.765C>T	c.(763-765)ctC>ctT	p.L255L	BDKRB1_ENST00000553356.1_Intron|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	255					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TCCTCACGCTCGTGGTTGCCT	0.597000													23	49					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27010070	27010070	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:27010070G>C	ENST00000314616.6	+	15	2121	c.1838G>C	c.(1837-1839)aGa>aCa	p.R613T	SUPT6H_ENST00000347486.4_Missense_Mutation_p.R613T	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	613					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TTCCAAGAGAGAGCCAAGTTA	0.532000													14	30					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19955493	19955493	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr20:19955493T>C	ENST00000255006.6	+	8	1120	c.971T>C	c.(970-972)cTt>cCt	p.L324P	RIN2_ENST00000440354.2_Intron|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	275					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						ATTAATCCCCTTTTCTTGAAA	0.567000													16	39					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12145726	12145726	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:12145726G>C	ENST00000566228.1	+	8	840	c.771G>C	c.(769-771)cgG>cgC	p.R257R		NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	349					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						AAAAGGAGCGGAAGAAGAAAA	0.408000													22	59					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53643891	53643891	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:53643891G>A	ENST00000452676.2	-	5	2619	c.2193C>T	c.(2191-2193)atC>atT	p.I731I	ZNF347_ENST00000601469.2_Silent_p.I731I|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000334197.7_Silent_p.I730I	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	730					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		TTCCAGTATGGATTGCCTGAT	0.438000													47	145					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119563241	119563241	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:119563241C>T	ENST00000267260.4	+	7	959	c.571C>T	c.(571-573)Cgg>Tgg	p.R191W	SRRM4_ENST00000537597.1_3'UTR	NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	191	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CTGCCCCTCGCGGTCCCAGAG	0.637000													4	69					0	0	1	0	0
CMIP	80790	broad.mit.edu	37	16	81740626	81740626	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:81740626G>A	ENST00000537098.3	+	20	2277	c.2205G>A	c.(2203-2205)aaG>aaA	p.K735K	CMIP_ENST00000566513.1_3'UTR|CMIP_ENST00000539778.2_Silent_p.K641K|CMIP_ENST00000398040.4_Silent_p.K582K	NM_198390.2	NP_938204.2	Q8IY22	CMIP_HUMAN	c-Maf inducing protein	701						cytoplasm|nucleus				endometrium(5)|kidney(1)|lung(7)	13						CAGCCATGAAGAGTCTCTGCA	0.522000													60	325					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128983509	128983509	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:128983509G>T	ENST00000274487.4	+	12	2051	c.1906G>T	c.(1906-1908)Gcc>Tcc	p.A636S	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	636	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TGAACATCTGGCCGGAGAGTG	0.507000													43	141					1.48734e-19	1.59157e-19	1	1	0
BRWD3	254065	broad.mit.edu	37	X	79975057	79975057	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:79975057C>G	ENST00000373275.4	-	18	2191	c.1975G>C	c.(1975-1977)Gac>Cac	p.D659H	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	659										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AGTCTCAGGTCTTGTTCTCTC	0.398000													34	22					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33330812	33330812	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr20:33330812T>A	ENST00000374796.2	-	12	5818	c.3248A>T	c.(3247-3249)cAa>cTa	p.Q1083L	NCOA6_ENST00000359003.2_Missense_Mutation_p.Q1083L			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1083	NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GGCAGGTCCTTGCAGACTGAC	0.527000													45	109					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2776783	2776783	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr20:2776783C>T	ENST00000380605.2	-	10	1331	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	423					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CAGCGGCCCTCGGCCCAGCCC	0.592000													6	107					0	0	1	0	0
GLUD2	2747	broad.mit.edu	37	X	120182405	120182405	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:120182405C>T	ENST00000328078.1	+	1	944	c.867C>T	c.(865-867)taC>taT	p.Y289Y		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	289					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	AAGCTTCTTACATGAGCATTT	0.433000													44	29					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732807	179732807	+	Silent	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:179732807G>T	ENST00000420890.2	-	16	2637	c.2520C>A	c.(2518-2520)ctC>ctA	p.L840L	CCDC141_ENST00000295723.5_Silent_p.L265L	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	265	Ig-like.						protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCAGTCTGTGGAGATGGTCTA	0.512000													19	70					3.32936e-07	3.45106e-07	1	1	0
GATM	2628	broad.mit.edu	37	15	45668818	45668818	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:45668818G>A	ENST00000396659.3	-	2	608	c.269C>T	c.(268-270)cCg>cTg	p.P90L	GATM_ENST00000558336.1_Missense_Mutation_p.P90L	NM_001482.2	NP_001473.1	P50440	GATM_HUMAN	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	90					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	15		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	GATGGTGAACGGTGGAACACA	0.537000													40	114					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42266824	42266824	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:42266824C>T	ENST00000319511.6	+	2	1060	c.410C>T	c.(409-411)gCc>gTc	p.A137V	TMUB2_ENST00000538716.2_Missense_Mutation_p.A157V|TMUB2_ENST00000589184.1_Intron|TMUB2_ENST00000587172.1_Intron|TMUB2_ENST00000587989.1_Missense_Mutation_p.A157V|TMUB2_ENST00000446571.3_Missense_Mutation_p.A100V|TMUB2_ENST00000592825.1_Intron|TMUB2_ENST00000357984.3_Missense_Mutation_p.A137V|TMUB2_ENST00000590235.1_Intron|TMUB2_ENST00000589785.1_Missense_Mutation_p.A137V|TMUB2_ENST00000589856.1_Missense_Mutation_p.A137V	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	157						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AGTCCAGAGGCCCCCCTGAGA	0.607000													24	79					0	0	1	0	0
ZNF766	90321	broad.mit.edu	37	19	52772874	52772874	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:52772874A>C	ENST00000439461.1	+	1	51	c.8A>C	c.(7-9)cAa>cCa	p.Q3P	ZNF766_ENST00000599581.1_Missense_Mutation_p.Q3P	NM_001010851.2	NP_001010851.1	Q5HY98	ZN766_HUMAN	zinc finger protein 766	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	17				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		GATATGGCGCAACTGCGGCGC	0.657000													16	57					0	0	1	0	0
IFNA4	3441	broad.mit.edu	37	9	21186980	21186980	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:21186980C>G	ENST00000421715.1	-	1	618	c.551G>C	c.(550-552)aGa>aCa	p.R184T		NM_021068.2	NP_066546.1	P05014	IFNA4_HUMAN	interferon, alpha 4	184					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CCTCCTTAATCTTTTTTGCAA	0.388000													7	327					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80408576	80408576	+	Silent	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:80408576C>G	ENST00000265080.4	+	14	2053	c.1986C>G	c.(1984-1986)ctC>ctG	p.L662L		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	662	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TTGATTTCCTCAACACCTTTC	0.502000													6	314					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20009578	20009578	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:20009578G>A	ENST00000294543.6	-	16	2101	c.1860C>T	c.(1858-1860)ccC>ccT	p.P620P	TMCO4_ENST00000489814.1_5'UTR|TMCO4_ENST00000375122.2_Silent_p.P580P|TMCO4_ENST00000375127.1_Intron	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	620						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AGGCACAATCGGGGCAGCCCA	0.652000													4	162					0	0	1	0	0
PLXDC1	57125	broad.mit.edu	37	17	37235397	37235397	+	Missense_Mutation	SNP	C	C	T	rs143709538		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:37235397C>T	ENST00000315392.4	-	10	1221	c.1010G>A	c.(1009-1011)cGc>cAc	p.R337H	PLXDC1_ENST00000539608.1_3'UTR|PLXDC1_ENST00000493200.1_5'UTR|PLXDC1_ENST00000444911.2_Missense_Mutation_p.R297H|CTD-2206N4.4_ENST00000583447.1_RNA	NM_020405.4	NP_065138.2	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1	337					angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction		p.R337H(1)		kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						CTGGCGATAGCGGTCAAAGCC	0.532000													14	67					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58589720	58589720	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:58589720G>A	ENST00000317147.5	-	20	2904	c.2572C>T	c.(2572-2574)Cat>Tat	p.H858Y	CNOT1_ENST00000569732.1_5'UTR|CNOT1_ENST00000569240.1_Missense_Mutation_p.H853Y|CNOT1_ENST00000441024.2_Missense_Mutation_p.H858Y	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	858					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGTGGTGGATGATTATATATT	0.403000													21	65					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603716	111603716	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:111603716G>T	ENST00000431670.2	+	2	1203	c.792G>T	c.(790-792)gaG>gaT	p.E264D	PHLDB2_ENST00000412622.1_Missense_Mutation_p.E264D|PHLDB2_ENST00000478922.1_Missense_Mutation_p.E264D|PHLDB2_ENST00000393925.3_Missense_Mutation_p.E264D|PHLDB2_ENST00000481953.1_Missense_Mutation_p.E264D|PHLDB2_ENST00000393923.3_Missense_Mutation_p.E291D|PHLDB2_ENST00000477695.1_Missense_Mutation_p.E264D	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	264						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GAGCCACAGAGAACCAGCTGA	0.483000													16	65					1.3612e-06	1.40363e-06	1	1	0
LRFN3	79414	broad.mit.edu	37	19	36430454	36430454	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:36430454G>A	ENST00000588831.1	+	3	1181	c.127G>A	c.(127-129)Gtg>Atg	p.V43M	LRFN3_ENST00000246529.3_Missense_Mutation_p.V43M			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	43	LRRNT.				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCCCCTAAGCGTGCTGTGCCC	0.721000													15	43					0	0	1	0	0
LMX1B	4010	broad.mit.edu	37	9	129376761	129376761	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:129376761G>C	ENST00000355497.5	+	1	40	c.33G>C	c.(31-33)gaG>gaC	p.E11D	LMX1B_ENST00000561065.1_5'UTR|LMX1B_ENST00000373474.4_Missense_Mutation_p.E11D|LMX1B_ENST00000526117.1_Missense_Mutation_p.E11D|LMX1B_ENST00000425646.2_5'UTR	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	0					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						AGTCGCTGGAGAGGTGCTTCC	0.731000									Nail-Patella Syndrome				10	17					0	0	1	0	0
AP3S2	10239	broad.mit.edu	37	15	90378779	90378779	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:90378779T>G	ENST00000336418.4	-	6	942	c.550A>C	c.(550-552)Atc>Ctc	p.I184L	AP3S2_ENST00000560940.1_Intron|C15orf38-AP3S2_ENST00000398333.3_Missense_Mutation_p.I385L|AP3S2_ENST00000558011.1_Missense_Mutation_p.I196L	NM_005829.4	NP_005820.1			adaptor-related protein complex 3, sigma 2 subunit											NS(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(1)	6	Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)			GGAACTTTGATGTTGAGATCG	0.498000													55	128					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7216583	7216583	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:7216583G>C	ENST00000380728.2	-	9	1052	c.752C>G	c.(751-753)tCc>tGc	p.S251C	GPS2_ENST00000391950.3_Missense_Mutation_p.S251C|GPS2_ENST00000389167.5_Missense_Mutation_p.S251C|RP11-542C16.2_ENST00000575474.1_3'UTR			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	251					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				CTTTTGCAAGGACAGGGCACC	0.552000											OREG0024133	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	118					0	0	1	0	0
CCND1	595	broad.mit.edu	37	11	69466022	69466022	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:69466022C>T	ENST00000227507.2	+	5	1087	c.860C>T	c.(859-861)cCc>cTc	p.P287L		NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	287					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding	p.P287L(1)|p.P287H(1)		NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	GCTTGCACACCCACCGACGTG	0.716000			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			10	28					0	0	1	0	0
RAD52	5893	broad.mit.edu	37	12	1023689	1023689	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:1023689G>C	ENST00000358495.3	-	10	1013	c.875C>G	c.(874-876)cCg>cGg	p.P292R	RAD52_ENST00000539046.1_Missense_Mutation_p.P215R|RAD52_ENST00000430095.2_Missense_Mutation_p.P292R|RAD52_ENST00000535376.1_5'UTR	NM_134424.2	NP_602296.2	P43351	RAD52_HUMAN	RAD52 homolog (S. cerevisiae)	292					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			AGGAGGGGCCGGAGGCGCTGC	0.517000								Homologous recombination					13	35					0	0	1	0	0
NAP1L1	4673	broad.mit.edu	37	12	76453586	76453586	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:76453586C>A	ENST00000261182.8	-	6	907	c.421G>T	c.(421-423)Gag>Tag	p.E141*	NAP1L1_ENST00000544816.1_5'UTR|NAP1L1_ENST00000535020.2_Nonsense_Mutation_p.E141*|NAP1L1_ENST00000393263.3_Nonsense_Mutation_p.E141*|NAP1L1_ENST00000548044.1_Nonsense_Mutation_p.E100*|NAP1L1_ENST00000542344.1_Nonsense_Mutation_p.E100*|NAP1L1_ENST00000549596.1_Nonsense_Mutation_p.E141*|NAP1L1_ENST00000431879.3_Intron|NAP1L1_ENST00000552342.1_Nonsense_Mutation_p.E141*|NAP1L1_ENST00000547773.1_Nonsense_Mutation_p.E78*	NM_004537.4|NM_139207.2	NP_004528.1|NP_631946.1	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	141	Asp/Glu-rich (acidic).				DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	9		Colorectal(145;0.09)				ACCGAAATCTCATCTTCTTCA	0.289000													8	21					0.00448238	0.00451651	1	1	0
SYMPK	8189	broad.mit.edu	37	19	46330777	46330777	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:46330777C>T	ENST00000245934.7	-	16	2416	c.2172G>A	c.(2170-2172)gaG>gaA	p.E724E		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	724					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CCTTGTCCTTCTCATGGGAGC	0.597000													13	42					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7773108	7773108	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:7773108G>A	ENST00000338316.4	+	18	2367	c.2278G>A	c.(2278-2280)Gag>Aag	p.E760K	ADCY2_ENST00000537121.1_Missense_Mutation_p.E580K	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	760					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGTAAACTATGAGCTGAAGAT	0.502000													46	126					0	0	1	0	0
SRPRB	58477	broad.mit.edu	37	3	133524729	133524729	+	Missense_Mutation	SNP	G	G	A	rs139369374	by1000genomes	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:133524729G>A	ENST00000466490.2	+	2	322	c.37G>A	c.(37-39)Ggc>Agc	p.G13S		NM_021203.3	NP_067026.3	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, B subunit	13						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			breast(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|urinary_tract(2)	12						GGCAGATGGCGGCGGTGCCGG	0.677000													34	79					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617325	77617325	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:77617325C>G	ENST00000521891.2	+	2	1450	c.1002C>G	c.(1000-1002)agC>agG	p.S334R	ZFHX4_ENST00000455469.2_Missense_Mutation_p.S334R|ZFHX4_ENST00000050961.6_Missense_Mutation_p.S334R|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.S334R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	334						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTCTTATAAGCTTTCTGGAAC	0.448000										HNSCC(33;0.089)			23	100					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161508855	161508855	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:161508855G>A	ENST00000392142.4	+	10	2840	c.2692G>A	c.(2692-2694)Gat>Aat	p.D898N	MAP3K4_ENST00000348824.7_Missense_Mutation_p.D898N|MAP3K4_ENST00000366920.2_Missense_Mutation_p.D898N|MAP3K4_ENST00000366919.2_Missense_Mutation_p.D898N	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	898					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CGTACTCATCGATGCCTATCT	0.507000													4	98					0	0	1	0	0
RAD23B	5887	broad.mit.edu	37	9	110091856	110091856	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:110091856G>C	ENST00000358015.3	+	10	1500	c.1149G>C	c.(1147-1149)gtG>gtC	p.V383V	RAD23B_ENST00000416373.2_Silent_p.V311V	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	383	UBA 2.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding	p.V383V(1)		breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						AAGGACTTGTGATACAAGCGT	0.318000								Direct reversal of damage;Nucleotide excision repair (NER)					40	65					0	0	1	0	0
GGA1	26088	broad.mit.edu	37	22	38012933	38012933	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:38012933C>G	ENST00000343632.4	+	3	519	c.133C>G	c.(133-135)Cca>Gca	p.P45A	GGA1_ENST00000325180.8_Missense_Mutation_p.P45A|GGA1_ENST00000414350.3_Missense_Mutation_p.P45A|GGA1_ENST00000406772.1_5'UTR|GGA1_ENST00000405147.3_Missense_Mutation_p.P45A|GGA1_ENST00000381756.5_Missense_Mutation_p.P45A|GGA1_ENST00000337437.4_Missense_Mutation_p.P45A	NM_001172687.1|NM_013365.4	NP_001166158.1|NP_037497.1	Q9UJY5	GGA1_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	45	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	10	Melanoma(58;0.0574)					ACCCAGGCCTCCACTCGCCAC	0.682000													5	12					0	0	1	0	0
ACTL6A	86	broad.mit.edu	37	3	179287900	179287900	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:179287900G>A	ENST00000429709.2	+	3	361	c.148G>A	c.(148-150)Gga>Aga	p.G50R	ACTL6A_ENST00000392662.1_Missense_Mutation_p.G8R|ACTL6A_ENST00000450518.2_Missense_Mutation_p.G8R	NM_004301.3	NP_004292.1	O96019	ACL6A_HUMAN	actin-like 6A	50					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	21	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			AAGAGATGACGGAAGCACATT	0.423000													5	138					0	0	1	0	0
HLX	3142	broad.mit.edu	37	1	221053273	221053273	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:221053273C>T	ENST00000366903.6	+	1	1575	c.74C>T	c.(73-75)gCc>gTc	p.A25V	HLA-AS1_ENST00000552026.1_RNA	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	25					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		TGCTCCTCGGCCGGCCCAGGC	0.697000													5	13					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35043437	35043437	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:35043437C>T	ENST00000312292.5	+	2	858	c.811C>T	c.(811-813)Cag>Tag	p.Q271*	C9orf131_ENST00000421362.2_Nonsense_Mutation_p.Q223*|C9orf131_ENST00000354479.5_Nonsense_Mutation_p.Q198*	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	271										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CCCCGATCCTCAGCTGCTTCC	0.547000													6	174					0	0	1	0	0
MFSD8	256471	broad.mit.edu	37	4	128886243	128886243	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:128886243C>T	ENST00000296468.3	-	2	173	c.46G>A	c.(46-48)Gac>Aac	p.D16N	MFSD8_ENST00000515130.1_5'UTR|MFSD8_ENST00000513559.1_Intron|MFSD8_ENST00000541133.1_Intron	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8	16					cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						CCAGGTGTGTCGCCTAAGAGC	0.617000													8	24					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563747	140563747	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:140563747C>T	ENST00000361016.2	+	1	2768	c.1613C>T	c.(1612-1614)tCc>tTc	p.S538F		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		538	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACCGCGGCTCCCCGGCTTTG	0.682000													47	42					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575889	179575889	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:179575889G>C	ENST00000589042.1	-	97	28298	c.28074C>G	c.(28072-28074)ctC>ctG	p.L9358L	TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.L8114L|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.L9041L|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9041	Ig-like 76.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAAAATATTGAGTGTGGCTG	0.453000													6	184					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130159096	130159096	+	Silent	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:130159096C>A	ENST00000265379.6	+	35	6408	c.5914C>A	c.(5914-5916)Cgg>Agg	p.R1972R	COL6A5_ENST00000432398.2_Silent_p.R1972R			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	1972	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						AGACAATTCTCGGAATATAGC	0.403000													9	28					1.12685e-05	1.15299e-05	1	1	0
SGSM2	9905	broad.mit.edu	37	17	2275527	2275527	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:2275527G>A	ENST00000268989.3	+	14	1798	c.1621G>A	c.(1621-1623)Gtg>Atg	p.V541M	SGSM2_ENST00000426855.2_Missense_Mutation_p.V496M|SGSM2_ENST00000574563.1_Missense_Mutation_p.V496M	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	496						intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GAGGCAGATCGTGTCCCGGGC	0.706000													37	109					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5153736	5153736	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:5153736C>T	ENST00000252321.3	+	1	652	c.423C>T	c.(421-423)ttC>ttT	p.F141F		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	141						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TGGCGCAGTTCCCCAACACAC	0.662000													4	63					0	0	1	0	0
MFSD2A	84879	broad.mit.edu	37	1	40434075	40434075	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:40434075C>T	ENST00000372809.5	+	12	1460	c.1317C>T	c.(1315-1317)atC>atT	p.I439I	MFSD2A_ENST00000480630.1_3'UTR|MFSD2A_ENST00000420632.2_Silent_p.I270I|MFSD2A_ENST00000372811.5_Silent_p.I426I	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A	439					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						CCGAGCCCATCTTCTTCTCCT	0.552000													20	50					0	0	1	0	0
KLHL41	10324	broad.mit.edu	37	2	170371456	170371456	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:170371456G>A	ENST00000284669.1	+	3	1438	c.1361G>A	c.(1360-1362)gGa>gAa	p.G454E	RP11-724O16.1_ENST00000513963.1_Missense_Mutation_p.G392E|KLHL41_ENST00000463400.1_3'UTR|BBS5_ENST00000554017.1_Missense_Mutation_p.G392E	NM_006063.2	NP_006054.2			kelch-like family member 41																		TGTCTAGGAGGAAAGACAGAT	0.323000													12	47					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52713011	52713011	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:52713011C>T	ENST00000293670.3	-	2	584	c.522G>A	c.(520-522)gtG>gtA	p.V174V		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	174	Coil 1B.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTCAGCCTCCACGCACTCGG	0.612000													38	110					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139748249	139748249	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:139748249G>C	ENST00000445819.1	+	5	525	c.475G>C	c.(475-477)Gag>Cag	p.E159Q	MAMDC4_ENST00000485732.1_3'UTR|MAMDC4_ENST00000317446.2_Missense_Mutation_p.E159Q			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	159	MAM 1.				protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		ACTGCGGGTGGAGCTGACCCA	0.706000													22	56					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123018978	123018978	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:123018978G>A	ENST00000462833.1	-	15	4101	c.2889C>T	c.(2887-2889)acC>acT	p.T963T	ADCY5_ENST00000491190.1_Silent_p.T596T|ADCY5_ENST00000309879.5_Silent_p.T613T	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	963					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TGGCGTTGGCGGTGACCAGCA	0.612000													17	57					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113851964	113851964	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:113851964T>G	ENST00000504030.2	+	4	749	c.304T>G	c.(304-306)Ttt>Gtt	p.F102V	HTR3A_ENST00000355556.2_Missense_Mutation_p.F108V|HTR3A_ENST00000375498.2_Missense_Mutation_p.F108V|HTR3A_ENST00000535865.1_5'UTR|HTR3A_ENST00000506841.2_Missense_Mutation_p.F102V|HTR3A_ENST00000299961.5_Missense_Mutation_p.F87V			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	102					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	CCCTGAGGACTTTGACAACAT	0.552000													17	45					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130863668	130863668	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:130863668C>G	ENST00000373066.5	+	3	834	c.427C>G	c.(427-429)Ctc>Gtc	p.L143V	SLC25A25_ENST00000373068.2_Missense_Mutation_p.L157V|SLC25A25_ENST00000432073.2_Missense_Mutation_p.L143V|SLC25A25_ENST00000433501.1_Missense_Mutation_p.L20V|SLC25A25_ENST00000373064.5_Missense_Mutation_p.L123V|SLC25A25_ENST00000373069.5_Missense_Mutation_p.L157V	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	123	EF-hand 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						AGAAAAAATTCTCAAGAGGTG	0.537000													5	64					0	0	1	0	0
XCR1	2829	broad.mit.edu	37	3	46063050	46063050	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:46063050C>T	ENST00000309285.3	-	2	746	c.390G>A	c.(388-390)tcG>tcA	p.S130S	XCR1_ENST00000542109.1_Silent_p.S130S	NM_001024644.1	NP_001019815.1	P46094	XCR1_HUMAN	chemokine (C motif) receptor 1	130					chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GGCTCACTACCGACAGGTAGC	0.592000													9	27					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2112870	2112870	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:2112870C>T	ENST00000355272.6	-	24	2982	c.2776G>A	c.(2776-2778)Gac>Aac	p.D926N	AP3D1_ENST00000350812.6_Intron|AP3D1_ENST00000356926.4_Missense_Mutation_p.D823N|AP3D1_ENST00000345016.5_Intron	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	872					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGTCCTGGTCTTGCCCCTCG	0.672000													12	46					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969673	118969673	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:118969673G>A	ENST00000515256.1	+	3	402	c.230G>A	c.(229-231)cGa>cAa	p.R77Q				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	77						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						AGAATACATCGAGACAGCCCC	0.512000													22	59					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147499606	147499606	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:147499606A>C	ENST00000359874.3	+	25	2421	c.2348A>C	c.(2347-2349)aAt>aCt	p.N783T	SPINK5_ENST00000398454.1_Missense_Mutation_p.N783T|SPINK5_ENST00000256084.7_Missense_Mutation_p.N783T	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	783	Kazal-like 12.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAATGAAAAATGGAAAACTC	0.378000													7	25					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154574693	154574693	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:154574693C>T	ENST00000368474.4	-	2	624	c.425G>A	c.(424-426)aGg>aAg	p.R142K	ADAR_ENST00000368471.3_5'UTR|ADAR_ENST00000471068.1_5'UTR|ADAR_ENST00000292205.5_Missense_Mutation_p.R185K	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	142					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		CTTTAAGATCCTTTGTTCCTG	0.488000													37	98					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51230664	51230664	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:51230664C>G	ENST00000245441.5	-	15	1844	c.1654G>C	c.(1654-1656)Gat>Cat	p.D552H	NIN_ENST00000382041.3_Missense_Mutation_p.D552H|NIN_ENST00000324330.9_Missense_Mutation_p.D552H|NIN_ENST00000389868.3_Missense_Mutation_p.D552H|NIN_ENST00000382043.4_Missense_Mutation_p.D552H|NIN_ENST00000453196.1_Missense_Mutation_p.D552H|NIN_ENST00000530997.2_Missense_Mutation_p.D552H	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	552					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TGGAGTTCATCTACTTGGTCT	0.433000			T	PDGFRB	MPD								27	71					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21989155	21989155	+	Missense_Mutation	SNP	G	G	A	rs147529801		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:21989155G>A	ENST00000292779.3	+	4	964	c.803G>A	c.(802-804)cGc>cAc	p.R268H		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	268										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					CCAATCTTCCGCAAGCGAGAG	0.602000													35	145					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367229	142367229	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:142367229C>T	ENST00000377741.3	-	2	885	c.795G>A	c.(793-795)gcG>gcA	p.A265A		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	265						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CGGGCCACAGCGCCACGGCCA	0.657000													4	50					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6219670	6219670	+	Silent	SNP	A	A	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:6219670A>G	ENST00000261405.5	-	5	656	c.402T>C	c.(400-402)taT>taC	p.Y134Y	VWF_ENST00000572068.1_Silent_p.Y171Y	NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	134	VWFD 1.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CCACAAAGCCATAGGCCTCAC	0.527000													34	124					0	0	1	0	0
MPHOSPH8	54737	broad.mit.edu	37	13	20220907	20220907	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:20220907A>G	ENST00000361479.5	+	3	762	c.694A>G	c.(694-696)Aag>Gag	p.K232E	MPHOSPH8_ENST00000414242.2_Missense_Mutation_p.K232E	NM_017520.3	NP_059990.2	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	232	Lys-rich.				cell cycle	cytoplasm|nucleus				breast(2)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		gaaagttaaaaagggtgaaat	0.303000													13	30					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155254404	155254404	+	Missense_Mutation	SNP	T	T	G	rs150770753		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:155254404T>G	ENST00000357232.3	-	9	1458	c.1459A>C	c.(1459-1461)Att>Ctt	p.I487L	DCHS2_ENST00000507542.1_5'UTR|DCHS2_ENST00000339452.1_Missense_Mutation_p.I986L	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	487	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GATATTCTAATCTCATCCGAG	0.597000													23	85					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42268085	42268085	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:42268085C>T	ENST00000319511.6	+	3	1409	c.759C>T	c.(757-759)ctC>ctT	p.L253L	TMUB2_ENST00000538716.2_Silent_p.L273L|TMUB2_ENST00000589184.1_3'UTR|TMUB2_ENST00000587172.1_3'UTR|TMUB2_ENST00000587989.1_Silent_p.L273L|TMUB2_ENST00000446571.3_Silent_p.L216L|TMUB2_ENST00000592825.1_3'UTR|TMUB2_ENST00000357984.3_Silent_p.L253L|TMUB2_ENST00000590235.1_3'UTR|TMUB2_ENST00000589785.1_Silent_p.L253L	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	273						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TGGGCAGCCTCATGGTGCCTG	0.617000													45	134					0	0	1	0	0
WDR70	55100	broad.mit.edu	37	5	37605166	37605166	+	Splice_Site	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:37605166G>T	ENST00000265107.4	+	10	1074	c.917_splice	c.e10-1	p.A306_splice	WDR70_ENST00000510699.1_3'UTR|WDR70_ENST00000504564.1_Splice_Site_p.A306_splice	NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	306										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCATTTTTAGGACTGTGAGGA	0.388000													9	20					3.09899e-07	3.22913e-07	1	1	0
USP37	57695	broad.mit.edu	37	2	219346853	219346853	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:219346853G>A	ENST00000258399.3	-	17	2187	c.1775C>T	c.(1774-1776)tCt>tTt	p.S592F	USP37_ENST00000418019.1_Missense_Mutation_p.S592F|USP37_ENST00000454775.1_Missense_Mutation_p.S592F|USP37_ENST00000415516.1_Missense_Mutation_p.S520F|USP37_ENST00000475553.1_5'UTR	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	592					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		AGTGCAATGAGATGACAGGGT	0.403000													39	65					0	0	1	0	0
DNAJC21	134218	broad.mit.edu	37	5	34945895	34945895	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:34945895A>T	ENST00000382021.2	+	9	1399	c.1172A>T	c.(1171-1173)cAg>cTg	p.Q391L	DNAJC21_ENST00000512136.1_3'UTR|DNAJC21_ENST00000342382.4_Missense_Mutation_p.Q391L|DNAJC21_ENST00000303525.7_Missense_Mutation_p.Q404L	NM_194283.3	NP_919259.3	Q5F1R6	DJC21_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 21	391	Poly-Lys.				protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			AAAAAGAAACAGAAACCAGCA	0.318000													23	101					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5776180	5776180	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:5776180G>A	ENST00000381624.3	+	21	2011	c.1950G>A	c.(1948-1950)gtG>gtA	p.V650V	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	650						integral to membrane											AGAACTATGTGAGCTGCCACG	0.632000													30	64					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3639432	3639432	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:3639432C>G	ENST00000294008.3	-	12	4847	c.4207G>C	c.(4207-4209)Gag>Cag	p.E1403Q		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1403	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						GAGGCCACCTCCTGCTCATCG	0.617000								Direct reversal of damage					7	192					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39133006	39133006	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:39133006G>A	ENST00000297668.6	-	13	2076	c.2003C>T	c.(2002-2004)tCc>tTc	p.S668F	CNTNAP3_ENST00000377656.2_Missense_Mutation_p.S667F|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.S574F|CNTNAP3_ENST00000377659.1_Missense_Mutation_p.S667F|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.S580F	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	668	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GTTCACCGCGGACCGCAGCTG	0.761000													6	9					0	0	1	0	0
C6orf89	221477	broad.mit.edu	37	6	36867326	36867326	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:36867326G>A	ENST00000480824.2	+	3	400	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	C6orf89_ENST00000510325.2_5'UTR|C6orf89_ENST00000373685.1_Missense_Mutation_p.E36K|C6orf89_ENST00000359359.2_5'UTR|C6orf89_ENST00000355190.3_Missense_Mutation_p.E43K			Q6UWU4	CF089_HUMAN	chromosome 6 open reading frame 89	36						integral to membrane		p.E43*(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						GAAGGCAATTGAAAAATTTAT	0.443000													23	75					0	0	1	0	0
SLC7A4	6545	broad.mit.edu	37	22	21385560	21385560	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:21385560G>C	ENST00000382932.2	-	2	609	c.542C>G	c.(541-543)tCt>tGt	p.S181C	SLC7A4_ENST00000403586.1_Missense_Mutation_p.S181C	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	181				THVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSS -> DPRGFLAGAPPGPLPGLPGCWHHPPWPLPLSPVEPACPP (in Ref. 1; CAA04263).	cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GACAAAGGCAGAGGCCAGGAG	0.597000													26	44					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20132802	20132802	+	Missense_Mutation	SNP	C	C	T	rs148311753	by1000genomes	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:20132802C>T	ENST00000334554.7	+	11	2318	c.2177C>T	c.(2176-2178)cCg>cTg	p.P726L	ZDHHC8_ENST00000320602.7_Missense_Mutation_p.P634L|ZDHHC8_ENST00000405930.3_Intron	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	726						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					GGGCAGTCCCCGGGCCTGGCC	0.632000													68	258					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42268014	42268014	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:42268014C>T	ENST00000319511.6	+	3	1338	c.688C>T	c.(688-690)Cca>Tca	p.P230S	TMUB2_ENST00000538716.2_Missense_Mutation_p.P250S|TMUB2_ENST00000589184.1_Missense_Mutation_p.S64F|TMUB2_ENST00000587172.1_3'UTR|TMUB2_ENST00000587989.1_Missense_Mutation_p.P250S|TMUB2_ENST00000446571.3_Missense_Mutation_p.P193S|TMUB2_ENST00000592825.1_3'UTR|TMUB2_ENST00000357984.3_Missense_Mutation_p.P230S|TMUB2_ENST00000590235.1_3'UTR|TMUB2_ENST00000589785.1_Missense_Mutation_p.P230S	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	250	Ubiquitin-like.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GTCAGCTGTTCCAGGCCCCTC	0.627000													35	98					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29259409	29259409	+	Silent	SNP	C	C	T	rs141848946	byFrequency	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:29259409C>T	ENST00000379558.4	+	18	2772	c.2421C>T	c.(2419-2421)gtC>gtT	p.V807V	FAM179A_ENST00000403861.2_Silent_p.V752V|FAM179A_ENST00000465300.1_3'UTR	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	807							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TTCAATAGGTCTTTGATGCTT	0.557000													22	62					0	0	1	0	0
RIOK2	55781	broad.mit.edu	37	5	96518836	96518836	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:96518836C>G	ENST00000283109.3	-	1	128	c.60G>C	c.(58-60)ttG>ttC	p.L20F	RIOK2_ENST00000508447.1_Missense_Mutation_p.L20F|CTD-2215E18.1_ENST00000509481.1_Missense_Mutation_p.Q53E	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	20							ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TTACCGCGGTCAAGACCCTGA	0.562000													43	164					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685698	100685698	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:100685698C>T	ENST00000306151.4	+	3	11065	c.11001C>T	c.(10999-11001)atC>atT	p.I3667I		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3667	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCTGTGATCACTTCTACCC	0.502000													9	313					0	0	1	0	0
ZNF689	115509	broad.mit.edu	37	16	30615770	30615770	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:30615770G>A	ENST00000287461.3	-	3	1655	c.1318C>T	c.(1318-1320)Cag>Tag	p.Q440*	RP11-146F11.5_ENST00000563540.1_RNA	NM_138447.1	NP_612456.1	Q96CS4	ZN689_HUMAN	zinc finger protein 689	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(1)	14			Colorectal(24;0.198)			TGGCTCCACTGAGCAAAACGC	0.677000													5	17					0	0	1	0	0
FBXO27	126433	broad.mit.edu	37	19	39517588	39517588	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:39517588G>A	ENST00000292853.4	-	5	749	c.630C>T	c.(628-630)gaC>gaT	p.D210D	FBXO27_ENST00000600828.1_Silent_p.D209D|FBXO27_ENST00000509137.2_Silent_p.D210D	NM_178820.3	NP_849142.1	Q8NI29	FBX27_HUMAN	F-box protein 27	210	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|urinary_tract(2)	17	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			TCTGGTTGGCGTCTAGAAGTT	0.562000													69	150					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73039771	73039771	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:73039771C>T	ENST00000335350.6	+	2	689	c.273C>T	c.(271-273)caC>caT	p.H91H	UNC5B_ENST00000373192.4_Silent_p.H91H	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	91	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						AGAACGACCACGTCACACAGG	0.642000													39	117					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10625900	10625900	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr20:10625900G>A	ENST00000254958.5	-	17	2633	c.2118C>T	c.(2116-2118)gaC>gaT	p.D706D	JAG1_ENST00000488480.1_RNA|JAG1_ENST00000423891.2_Silent_p.D547D	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	706	EGF-like 13.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						CACACTGACTGTCACCTGGAG	0.547000									Alagille Syndrome				17	65					0	0	1	0	0
AHI1	54806	broad.mit.edu	37	6	135639718	135639718	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:135639718C>T	ENST00000367800.4	-	24	3581	c.3365G>A	c.(3364-3366)cGa>cAa	p.R1122Q	AHI1_ENST00000417892.2_Missense_Mutation_p.R476Q|AHI1_ENST00000457866.2_Missense_Mutation_p.R1122Q	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	1122						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		AGGAGGGGATCGCTCCTTTAT	0.388000													3	4					0	0	1	0	0
RAC1	5879	broad.mit.edu	37	7	6426892	6426892	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:6426892C>T	ENST00000348035.4	+	2	298	c.85C>T	c.(85-87)Cct>Tct	p.P29S	RAC1_ENST00000488373.1_3'UTR|RAC1_ENST00000356142.4_Missense_Mutation_p.P29S	NM_006908.4	NP_008839.2	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	29					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding	p.P29S(1)		cervix(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CAATGCATTTCCTGGAGAATA	0.353000													10	45					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46567252	46567252	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:46567252G>C	ENST00000458649.2	-	5	871	c.453C>G	c.(451-453)ctC>ctG	p.L151L	AMBRA1_ENST00000426438.1_Silent_p.L151L|AMBRA1_ENST00000528950.1_Silent_p.L151L|AMBRA1_ENST00000534300.1_Silent_p.L151L|AMBRA1_ENST00000533727.1_Silent_p.L151L|AMBRA1_ENST00000314845.3_Silent_p.L151L|AMBRA1_ENST00000298834.3_Silent_p.L151L			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	151					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CAATCAGCAGGAGCTGAGCCG	0.532000													19	64					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77895275	77895275	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr18:77895275C>T	ENST00000262198.4	+	4	2434	c.1979C>T	c.(1978-1980)cCc>cTc	p.P660L		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	660					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CCCGGCATGCCCTCTCCTCCA	0.632000													33	62					0	0	1	0	0
BSDC1	55108	broad.mit.edu	37	1	32843848	32843848	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:32843848G>A	ENST00000341071.7	-	7	627	c.616C>T	c.(616-618)Cgg>Tgg	p.R206W	BSDC1_ENST00000419121.2_Missense_Mutation_p.R133W|BSDC1_ENST00000413080.1_Intron|BSDC1_ENST00000449308.1_Missense_Mutation_p.R189W|BSDC1_ENST00000446293.2_Missense_Mutation_p.R206W|BSDC1_ENST00000526031.1_Missense_Mutation_p.R94W|BSDC1_ENST00000455895.2_Missense_Mutation_p.R189W			Q9NW68	BSDC1_HUMAN	BSD domain containing 1	189							protein binding	p.R206W(1)		breast(1)|central_nervous_system(2)|kidney(1)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TAGAAATACCGATGCCAGAAT	0.522000													15	61					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82969304	82969304	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:82969304G>A	ENST00000274341.4	-	2	889	c.39C>T	c.(37-39)tgC>tgT	p.C13C	HAPLN1_ENST00000514416.1_Silent_p.C13C	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	13					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GATCAGCCCAGCAGATTGAAA	0.403000													36	61					0	0	1	0	0
NECAB2	54550	broad.mit.edu	37	16	84030833	84030833	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:84030833G>T	ENST00000565691.1	+	7	1281	c.559G>T	c.(559-561)Gac>Tac	p.D187Y	NECAB2_ENST00000567703.1_3'UTR|NECAB2_ENST00000305202.4_Missense_Mutation_p.D270Y			Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	270					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						ACTGTGGTTCGACCTGCAGCA	0.617000													16	65					1.99824e-07	2.08763e-07	1	1	0
CAMK2B	816	broad.mit.edu	37	7	44280308	44280308	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:44280308G>A	ENST00000395749.2	-	12	1020	c.944C>T	c.(943-945)tCa>tTa	p.S315L	CAMK2B_ENST00000350811.3_Missense_Mutation_p.S315L|CAMK2B_ENST00000440254.2_Missense_Mutation_p.S315L|CAMK2B_ENST00000457475.1_Missense_Mutation_p.S315L|CAMK2B_ENST00000395747.2_Missense_Mutation_p.S315L|CAMK2B_ENST00000502837.2_Missense_Mutation_p.S186L|CAMK2B_ENST00000258682.6_Missense_Mutation_p.S315L|CAMK2B_ENST00000346990.4_Missense_Mutation_p.S315L|CAMK2B_ENST00000353625.4_Missense_Mutation_p.S315L|CAMK2B_ENST00000358707.3_Missense_Mutation_p.S315L|CAMK2B_ENST00000347193.4_Missense_Mutation_p.S315L	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	315					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						AGGCTCACCTGAGAAATTCCG	0.617000													7	32					0	0	1	0	0
HEY2	23493	broad.mit.edu	37	6	126080335	126080335	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:126080335C>T	ENST00000368364.3	+	5	598	c.401C>T	c.(400-402)gCg>gTg	p.A134V	HEY2_ENST00000368365.1_Missense_Mutation_p.A88V	NM_012259.2	NP_036391.1	Q9UBP5	HEY2_HUMAN	hes-related family bHLH transcription factor with YRPW motif 2	134	Orange.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding	p.A134V(2)		breast(1)|large_intestine(7)|lung(5)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		ACAGAAGTTGCGCGGTACCTG	0.587000													26	95					0	0	1	0	0
TUBA1B	10376	broad.mit.edu	37	12	49523132	49523132	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:49523132C>G	ENST00000336023.5	-	3	362	c.268G>C	c.(268-270)Gag>Cag	p.E90Q	RP11-386G11.10_ENST00000547387.1_RNA	NM_006082.2	NP_006073.2	P68363	TBA1B_HUMAN	tubulin, alpha 1b	90					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(4)	12						ATGAGCTGCTCAGGGTGGAAG	0.552000													5	168					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684956	100684956	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:100684956C>G	ENST00000306151.4	+	3	10323	c.10259C>G	c.(10258-10260)tCa>tGa	p.S3420*		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3420	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACACCCTTTCAACAACTCCT	0.502000													16	549					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936965	15936965	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:15936965C>T	ENST00000504595.1	+	4	1627	c.1146C>T	c.(1144-1146)aaC>aaT	p.N382N	FBXL7_ENST00000510662.1_Silent_p.N335N|FBXL7_ENST00000329673.7_Silent_p.N370N	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	382					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GCTACCTCAACGCGAGGGGCT	0.617000													5	24					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247014083	247014083	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:247014083C>G	ENST00000366508.1	-	33	5466	c.5330G>C	c.(5329-5331)aGa>aCa	p.R1777T	AHCTF1_ENST00000326225.3_Missense_Mutation_p.R1751T|AHCTF1_ENST00000391829.2_Missense_Mutation_p.R1742T|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1742	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			ACGTTGACCTCTCGTACGAGT	0.443000													14	43					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121220601	121220601	+	Splice_Site	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:121220601G>A	ENST00000297848.3	+	11	1591		c.e11+1		COL14A1_ENST00000247781.3_Splice_Site|COL14A1_ENST00000432943.2_Splice_Site|COL14A1_ENST00000309791.4_Splice_Site|COL14A1_ENST00000537875.1_Splice_Site	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GAAACTACACGTATGTATTTA	0.403000													22	36					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34671826	34671826	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:34671826G>A	ENST00000374789.3	-	9	1366	c.1041C>T	c.(1039-1041)gcC>gcT	p.A347A	PARD3_ENST00000340077.5_Silent_p.A347A|PARD3_ENST00000374776.1_Silent_p.A347A|PARD3_ENST00000545260.1_Silent_p.A303A|PARD3_ENST00000544292.1_Silent_p.A77A|PARD3_ENST00000346874.4_Silent_p.A347A|PARD3_ENST00000374773.1_Silent_p.A347A|PARD3_ENST00000350537.4_Silent_p.A347A|PARD3_ENST00000374788.3_Silent_p.A347A|PARD3_ENST00000545693.1_Silent_p.A347A|PARD3_ENST00000374790.3_Silent_p.A303A|PARD3_ENST00000374794.3_Silent_p.A303A	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	347	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				GTGTACGCATGGCTTGGCGAA	0.378000													37	106					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171481612	171481612	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:171481612C>T	ENST00000176763.5	-	17	2956	c.2613G>A	c.(2611-2613)gcG>gcA	p.A871A		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	871	Gln-rich.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTCACACTGCGCCAGCATGT	0.627000													66	136					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102028295	102028295	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:102028295C>T	ENST00000510508.4	+	1	608	c.462C>T	c.(460-462)taC>taT	p.Y154Y	DIO3_ENST00000359323.3_Silent_p.Y128Y			P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	128					cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)|skin(1)	22		all_neural(303;0.185)				TCCTCGACTACGCGCAAGGGA	0.627000													27	72					0	0	1	0	0
EPN1	29924	broad.mit.edu	37	19	56206609	56206609	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:56206609C>G	ENST00000411543.2	+	11	2423	c.1876C>G	c.(1876-1878)Ccc>Gcc	p.P626A	EPN1_ENST00000085079.7_Missense_Mutation_p.P514A|EPN1_ENST00000270460.6_Missense_Mutation_p.P540A	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	540					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		TCCTGTGCCTCCCGTCCCTGG	0.716000													9	28					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233273429	233273429	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:233273429G>C	ENST00000295453.3	+	8	924	c.872G>C	c.(871-873)gGa>gCa	p.G291A		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	291					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	TTTGAGCCTGGAGACATGAAA	0.627000													5	24					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46654578	46654578	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:46654578G>C	ENST00000253255.5	-	1	4641	c.4642C>G	c.(4642-4644)Cag>Gag	p.Q1548E		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1548					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TGGACATCCTGATCATCTTCT	0.488000													61	195					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23190959	23190959	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:23190959G>A	ENST00000389131.3	-	5	1290	c.921C>T	c.(919-921)ttC>ttT	p.F307F	LOXL2_ENST00000518472.1_5'UTR	NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	307					aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		CGTCAGGGCTGAAGACCTGCC	0.632000													32	101					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31323268	31323268	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:31323268A>C	ENST00000412585.2	-	4	749	c.721T>G	c.(721-723)Tgg>Ggg	p.W241G		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B									p.W241R(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						TCCCGCTGCCAGGTCAGTGTG	0.612000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				44	144					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109816662	109816662	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:109816662C>A	ENST00000271332.3	+	34	8824	c.8763C>A	c.(8761-8763)ttC>ttA	p.F2921L	CELSR2_ENST00000498157.1_3'UTR	NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2921					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TCTTTAACTTCCTGCATTAAC	0.542000													6	218					0.00198382	0.00200401	1	1	0
ZYG11B	79699	broad.mit.edu	37	1	53287268	53287268	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:53287268C>T	ENST00000294353.6	+	14	2347	c.2202C>T	c.(2200-2202)ccC>ccT	p.P734P	ZYG11B_ENST00000443756.2_Silent_p.P664P	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	734							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						GGCCACCTCCCTGTAAAAAAC	0.423000													16	49					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110519954	110519954	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:110519954G>C	ENST00000378402.5	+	69	11161	c.11057G>C	c.(11056-11058)aGa>aCa	p.R3686T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3686					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCTTTTCTTAGAGACATAGAT	0.408000										HNSCC(38;0.096)			20	58					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72363371	72363371	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:72363371C>G	ENST00000340595.3	+	13	2192	c.1996C>G	c.(1996-1998)Ctg>Gtg	p.L666V	SLC4A4_ENST00000351898.6_Missense_Mutation_p.L710V|SLC4A4_ENST00000425175.1_Missense_Mutation_p.L710V|SLC4A4_ENST00000264485.5_Missense_Mutation_p.L710V	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	710						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TTCCATGGCTCTGAAAAAATT	0.363000													25	87					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52927235	52927235	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:52927235C>G	ENST00000371544.3	-	18	3443	c.3181G>C	c.(3181-3183)Gaa>Caa	p.E1061Q	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.E1061Q	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1061					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						CGCCTGTGTTCAAATTTTACT	0.279000													18	21					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47307709	47307709	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:47307709C>G	ENST00000377065.4	-	5	2099	c.1460G>C	c.(1459-1461)aGa>aCa	p.R487T	ZNF41_ENST00000313116.7_Missense_Mutation_p.R487T|ZNF41_ENST00000397050.2_Missense_Mutation_p.R497T	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	529						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				GGTGTGAATTCTTTGATGCAC	0.423000													3	42					0	0	1	0	0
SCEL	8796	broad.mit.edu	37	13	78171683	78171683	+	Silent	SNP	A	A	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:78171683A>G	ENST00000535157.1	+	12	860	c.690A>G	c.(688-690)gaA>gaG	p.E230E	SCEL_ENST00000469982.1_3'UTR|SCEL_ENST00000349847.3_Silent_p.E252E|SCEL_ENST00000377246.3_Silent_p.E232E	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	252					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		CCCAAAGTGAAGAATTGGATA	0.303000													8	18					0	0	1	0	0
OR5AU1	390445	broad.mit.edu	37	14	21624144	21624144	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:21624144C>G	ENST00000304418.3	-	1	78	c.41G>C	c.(40-42)aGa>aCa	p.R14T		NM_001004731.1	NP_001004731.1	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		GAAGATGAGTCTTATTGAGGG	0.448000													50	164					0	0	1	0	0
GNPTAB	79158	broad.mit.edu	37	12	102158732	102158732	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:102158732G>A	ENST00000299314.7	-	13	2225	c.1963C>T	c.(1963-1965)Ccc>Tcc	p.P655S		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	655					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						AGTGTTATGGGACTAACTAAA	0.423000													21	60					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92380902	92380902	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:92380902G>A	ENST00000377067.3	+	4	1509	c.1137G>A	c.(1135-1137)acG>acA	p.T379T	GPC5_ENST00000483422.1_3'UTR	NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	379						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GTGAAGAGACGCTTGCCAACA	0.393000													37	94					0	0	1	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44632664	44632664	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:44632664C>G	ENST00000576629.1	+	14	5423	c.4928C>G	c.(4927-4929)tCa>tGa	p.S1643*	ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000329240.4_Intron|ARL17A_ENST00000570550.1_Intron|ARL17A_ENST00000445552.2_Intron|ARL17A_ENST00000337845.7_Intron|ARL17A_ENST00000336125.5_3'UTR|LRRC37A2_ENST00000333412.3_Nonsense_Mutation_p.S1643*			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1643						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		GGACTTTCCTCATTTGGACAG	0.418000													4	205					0	0	1	0	0
ZNF205	7755	broad.mit.edu	37	16	3168975	3168975	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:3168975G>A	ENST00000382192.3	+	6	759	c.554G>A	c.(553-555)cGg>cAg	p.R185Q	RP11-473M20.14_ENST00000575139.1_RNA|RP11-473M20.14_ENST00000576490.1_RNA|ZNF205_ENST00000219091.4_Missense_Mutation_p.R185Q	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	185	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						GGCTCCAGCCGGCAGGCAGGA	0.667000													52	140					0	0	1	0	0
MMP27	64066	broad.mit.edu	37	11	102564693	102564693	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:102564693G>A	ENST00000260229.4	-	8	1228	c.1137C>T	c.(1135-1137)gcC>gcT	p.A379A		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	379	Hemopexin-like 3.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TATCACAGACGGCTGCATCTA	0.393000													44	99					0	0	1	0	0
AP2B1	163	broad.mit.edu	37	17	33932734	33932734	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:33932734C>G	ENST00000262325.7	+	4	707	c.154C>G	c.(154-156)Cca>Gca	p.P52A	AP2B1_ENST00000589344.1_Missense_Mutation_p.P52A|AP2B1_ENST00000538556.1_5'UTR|AP2B1_ENST00000537622.2_Missense_Mutation_p.P52A|AP2B1_ENST00000592545.1_Missense_Mutation_p.P52A|AP2B1_ENST00000312678.8_Missense_Mutation_p.P52A	NM_001282.2	NP_001273.1	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1 subunit	52					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TTCTCTCTTTCCAGACGTAGT	0.438000													20	88					0	0	1	0	0
TMEM37	140738	broad.mit.edu	37	2	120194618	120194618	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:120194618G>A	ENST00000306406.4	+	2	210	c.175G>A	c.(175-177)Ggg>Agg	p.G59R	TMEM37_ENST00000409826.1_Missense_Mutation_p.G71R|TMEM37_ENST00000465296.1_3'UTR	NM_183240.2	NP_899063.2	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	59						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						CCGCCTCTTCGGGCTCTGGCA	0.647000													30	107					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109694273	109694273	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:109694273T>C	ENST00000465301.2	+	3	674	c.428T>C	c.(427-429)aTg>aCg	p.M143T	RGAG1_ENST00000540313.1_Missense_Mutation_p.M143T	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	143										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						CCAGGGATGATGACAATTCCT	0.502000													60	41					0	0	1	0	0
TRPV1	7442	broad.mit.edu	37	17	3489147	3489147	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:3489147C>T	ENST00000174621.6	-	7	1581	c.1292G>A	c.(1291-1293)cGc>cAc	p.R431H	SHPK_ENST00000572705.1_Missense_Mutation_p.R433H|TRPV1_ENST00000425167.2_Missense_Mutation_p.R444H|TRPV1_ENST00000399756.4_Missense_Mutation_p.R433H|TRPV1_ENST00000576351.1_Missense_Mutation_p.R423H|TRPV1_ENST00000310522.5_Missense_Mutation_p.R373H|TRPV1_ENST00000571088.1_Missense_Mutation_p.R433H|TRPV1_ENST00000399759.3_Missense_Mutation_p.R433H			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	433					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	GTAGAAGATGCGCTTGACGAA	0.562000													9	37					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60498986	60498986	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:60498986T>C	ENST00000400324.4	-	18	2313	c.2093A>G	c.(2092-2094)gAt>gGt	p.D698G	DIAPH3_ENST00000400319.1_Missense_Mutation_p.D628G|DIAPH3_ENST00000400320.1_Missense_Mutation_p.D652G|DIAPH3_ENST00000400330.1_Missense_Mutation_p.D698G|DIAPH3_ENST00000377908.2_Missense_Mutation_p.D687G|DIAPH3_ENST00000267215.4_Missense_Mutation_p.D698G|DIAPH3_ENST00000465066.1_5'UTR	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	698	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		CTCTTCAATATCTTCCTCTTC	0.299000													5	18					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42266848	42266848	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:42266848C>T	ENST00000319511.6	+	2	1084	c.434C>T	c.(433-435)aCc>aTc	p.T145I	TMUB2_ENST00000538716.2_Missense_Mutation_p.T165I|TMUB2_ENST00000589184.1_Intron|TMUB2_ENST00000587172.1_Intron|TMUB2_ENST00000587989.1_Missense_Mutation_p.T165I|TMUB2_ENST00000446571.3_Missense_Mutation_p.T108I|TMUB2_ENST00000592825.1_Intron|TMUB2_ENST00000357984.3_Missense_Mutation_p.T145I|TMUB2_ENST00000590235.1_Intron|TMUB2_ENST00000589785.1_Missense_Mutation_p.T145I|TMUB2_ENST00000589856.1_Missense_Mutation_p.T145I	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	165						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GAGGATAGCACCTGCCTCCCT	0.607000													21	72					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824313	54824313	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr20:54824313C>T	ENST00000243911.2	+	1	526	c.414C>T	c.(412-414)atC>atT	p.I138I		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	175					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			TCCTGGCCATCGCCGTCGACA	0.567000													31	66					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5664425	5664425	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:5664425C>G	ENST00000292123.5	+	17	2416	c.2309C>G	c.(2308-2310)tCa>tGa	p.S770*	SAFB_ENST00000592224.1_Nonsense_Mutation_p.S769*|SAFB_ENST00000538656.1_Nonsense_Mutation_p.S612*|SAFB_ENST00000454510.1_Nonsense_Mutation_p.S701*|SAFB_ENST00000433404.1_Nonsense_Mutation_p.S600*|SAFB_ENST00000588852.1_Nonsense_Mutation_p.S770*	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	770	Arg-rich.|Interaction with POLR2A.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GGTTCAAGGTCAATGATGGGA	0.463000													21	54					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5622611	5622611	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:5622611C>T	ENST00000252542.4	-	1	380	c.116G>A	c.(115-117)cGg>cAg	p.R39Q		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	39	SAP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CAGCTCCGCCCGCAGATCGAT	0.721000													4	30					0	0	1	0	0
TUBD1	51174	broad.mit.edu	37	17	57958466	57958466	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:57958466G>A	ENST00000325752.3	-	4	603	c.326C>T	c.(325-327)tCt>tTt	p.S109F	TUBD1_ENST00000376094.4_Missense_Mutation_p.S109F|TUBD1_ENST00000539018.1_Intron|TUBD1_ENST00000592426.1_Missense_Mutation_p.S109F|TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000394239.3_Missense_Mutation_p.S109F|TUBD1_ENST00000340993.6_Missense_Mutation_p.S109F|TUBD1_ENST00000591611.1_Intron	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	109					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TCCATGAACAGAGTAACTATG	0.353000													21	70					0	0	1	0	0
MBLAC2	153364	broad.mit.edu	37	5	89769875	89769875	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:89769875C>T	ENST00000316610.6	-	1	710	c.235G>A	c.(235-237)Gcc>Acc	p.A79T	MBLAC2_ENST00000514906.1_Missense_Mutation_p.A79T	NM_203406.1	NP_981951.1	Q68D91	MBLC2_HUMAN	metallo-beta-lactamase domain containing 2	79							hydrolase activity|metal ion binding			kidney(1)|liver(1)|lung(3)	5						GTGGCCACGGCAAGCAGTGGC	0.711000													7	14					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	562846	562846	+	Splice_Site	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:562846C>T	ENST00000230449.4	-	17	1925		c.e17-1		EXOC2_ENST00000448181.3_Splice_Site	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2						exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		CTCTTTATTTCTATATGAGAA	0.259000													7	19					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33293223	33293223	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:33293223G>A	ENST00000280979.4	+	13	6374	c.6204G>A	c.(6202-6204)tcG>tcA	p.S2068S	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	2068	PKA-RII subunit binding domain.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACATGGCTTCGACAGCCCTAA	0.423000													22	46					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373545	126373545	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:126373545C>T	ENST00000394329.3	+	9	11387	c.11374C>T	c.(11374-11376)Cgg>Tgg	p.R3792W	FAT4_ENST00000335110.5_Missense_Mutation_p.R2090W	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3792					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GATCCTTCTCCGGCAGAGTGG	0.483000													22	62					0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3103948	3103948	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:3103948G>A	ENST00000359864.2	+	3	206	c.16G>A	c.(16-18)Ggc>Agc	p.G6S	TEAD4_ENST00000358409.2_Missense_Mutation_p.G6S|TEAD4_ENST00000397122.2_Intron	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	6					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GGGCACGGCCGGCACCATTAC	0.662000													28	78					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180335696	180335696	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:180335696C>T	ENST00000231229.4	+	2	394	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W	BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000508408.1_Missense_Mutation_p.R54W|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000340184.4_Missense_Mutation_p.R54W	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	54	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATGGAAGTGCGGTTCTTCAG	0.562000													34	110					0	0	1	0	0
ST20	400410	broad.mit.edu	37	15	80191317	80191317	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:80191317G>C	ENST00000478497.1	-	3	875	c.196C>G	c.(196-198)Ctg>Gtg	p.L66V	ST20_ENST00000485386.1_Missense_Mutation_p.L66V|ST20-MTHFS_ENST00000479961.1_Intron|ST20-MTHFS_ENST00000494999.1_Intron|ST20_ENST00000562759.1_Missense_Mutation_p.L66V	NM_001100879.1	NP_001094349.1			suppressor of tumorigenicity 20											kidney(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4						GTAAGAGTCAGAAAAATTAGG	0.373000													22	79					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26688651	26688651	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:26688651C>T	ENST00000436292.1	-	6	1279	c.1159G>A	c.(1159-1161)Gga>Aga	p.G387R	ZNF683_ENST00000374204.1_Intron|ZNF683_ENST00000349618.3_Intron|ZNF683_ENST00000403843.1_Missense_Mutation_p.G387R			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		TGATTTCTTCCTGGAACCCAC	0.502000													5	19					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235335980	235335980	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:235335980G>A	ENST00000264183.3	-	23	4261	c.3764C>T	c.(3763-3765)gCt>gTt	p.A1255V	ARID4B_ENST00000349213.3_Missense_Mutation_p.A1169V|ARID4B_ENST00000366603.2_Missense_Mutation_p.A1255V	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	1255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			ATCAATGGAAGCTACTTCAGA	0.318000													4	19					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89499368	89499368	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:89499368C>T	ENST00000336596.2	+	15	2763	c.2538C>T	c.(2536-2538)ccC>ccT	p.P846P	EPHA3_ENST00000494014.1_Silent_p.P846P	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	846	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGCCACCCCCCATGGACTGCC	0.473000										TSP Lung(6;0.00050)			14	40					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75015200	75015200	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:75015200G>C	ENST00000379727.3	-	2	437	c.239C>G	c.(238-240)tCc>tGc	p.S80C	CYP1A1_ENST00000567032.1_Missense_Mutation_p.S80C|CYP1A1_ENST00000395048.2_Missense_Mutation_p.S80C|CYP1A1_ENST00000395049.4_Missense_Mutation_p.S80C|CYP1A1_ENST00000564596.1_Intron			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	80					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	CACGGGTGTGGAGCCAATTCG	0.632000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				17	54					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423371	26423371	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:26423371G>A	ENST00000335473.7	+	43	7681	c.7431G>A	c.(7429-7431)acG>acA	p.T2477T	MYO18B_ENST00000407587.2_Silent_p.T2478T|MYO18B_ENST00000536101.1_Silent_p.T2477T	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2477						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						ACTTTGAAACGGAAGAGGCTA	0.557000													27	68					0	0	1	0	0
CLDN16	10686	broad.mit.edu	37	3	190106101	190106101	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:190106101G>A	ENST00000264734.2	+	1	441	c.193G>A	c.(193-195)Gat>Aat	p.D65N	CLDN16_ENST00000456423.1_Missense_Mutation_p.D65N|CLDN16_ENST00000468220.1_Intron	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	65					calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		TTGCCATCCTGATGGGCTGCT	0.507000													37	94					0	0	1	0	0
UBE4A	9354	broad.mit.edu	37	11	118235857	118235857	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:118235857C>G	ENST00000252108.3	+	2	193	c.62C>G	c.(61-63)tCc>tGc	p.S21C	UBE4A_ENST00000431736.2_Missense_Mutation_p.S21C	NM_001204077.1|NM_004788.3	NP_001191006.1|NP_004779.2	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	21					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(7)|liver(2)|lung(14)|ovary(3)|prostate(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	56	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CTTTTTGGCTCCCTGGCTGAT	0.458000													12	34					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158747097	158747097	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:158747097G>A	ENST00000339258.1	-	1	328	c.329C>T	c.(328-330)tCt>tTt	p.S110F		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					GTAGCATTCAGACGCTCCCAA	0.463000													22	93					0	0	1	0	0
TUBD1	51174	broad.mit.edu	37	17	57955640	57955640	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:57955640G>C	ENST00000325752.3	-	5	870	c.593C>G	c.(592-594)tCa>tGa	p.S198*	TUBD1_ENST00000376094.4_Nonsense_Mutation_p.S198*|TUBD1_ENST00000539018.1_5'UTR|TUBD1_ENST00000592426.1_Nonsense_Mutation_p.S198*|TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000394239.3_Nonsense_Mutation_p.S198*|TUBD1_ENST00000340993.6_Nonsense_Mutation_p.S198*	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	198					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			GAGGGCGTCTGAAGATCGGTA	0.388000													28	95					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230632274	230632274	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:230632274G>T	ENST00000283943.5	-	41	6153	c.5975C>A	c.(5974-5976)tCc>tAc	p.S1992Y	TRIP12_ENST00000389045.3_Missense_Mutation_p.S1722Y|TRIP12_ENST00000389044.4_Missense_Mutation_p.S2040Y	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1992	HECT.			SSIEIMREKLLIAAREGQQSFHLS -> QALRYA (in Ref. 2).	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CTATGATCAGGAAAGATGGAA	0.393000													6	110					5.9392e-07	6.14027e-07	1	1	0
MYH9	4627	broad.mit.edu	37	22	36710351	36710351	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:36710351C>G	ENST00000216181.5	-	13	1623	c.1393G>C	c.(1393-1395)Gag>Cag	p.E465Q		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	465	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CACAGCTGCTCAAACGAGTTC	0.547000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				4	93					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53227877	53227877	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:53227877G>C	ENST00000330553.5	-	1	202	c.168C>G	c.(166-168)ggC>ggG	p.G56G		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	56	Head.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GGCTGCCAAAGCCACCTGTGC	0.667000													28	95					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370926	240370926	+	Silent	SNP	C	C	T	rs71170718		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:240370926C>T	ENST00000319653.9	+	5	3044	c.2814C>T	c.(2812-2814)ccC>ccT	p.P938P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	938	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.P1081P(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCTCTACCCGGAGCGGGAA	0.697000													34	50					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415715	86415715	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:86415715G>A	ENST00000361669.2	+	3	1706	c.607G>A	c.(607-609)Gag>Aag	p.E203K	AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000439827.1_Missense_Mutation_p.E203K|GRM3_ENST00000546348.1_Intron|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000536043.1_Missense_Mutation_p.E75K|GRM3_ENST00000394720.2_Missense_Mutation_p.E201K	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	203					synaptic transmission	integral to plasma membrane		p.E203Q(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AGCCATGGCTGAGATCTTGCG	0.582000													45	94					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142571366	142571366	+	Silent	SNP	G	G	A	rs147746494		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:142571366G>A	ENST00000359396.3	-	13	1868	c.1623C>T	c.(1621-1623)atC>atT	p.I541I		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	541					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CTGGGCCATCGATGATGGTAA	0.542000													112	106					0	0	1	0	0
FBXW5	54461	broad.mit.edu	37	9	139837261	139837261	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:139837261C>T	ENST00000325285.3	-	4	565	c.486G>A	c.(484-486)ccG>ccA	p.P162P	FBXW5_ENST00000483559.1_5'UTR	NM_018998.3	NP_061871.1	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	162							catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		AGGAGTTGTGCGGCCCCAGGA	0.662000													5	100					0	0	1	0	0
HYAL1	3373	broad.mit.edu	37	3	50339650	50339650	+	Silent	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr3:50339650G>T	ENST00000266031.4	-	1	1353	c.738C>A	c.(736-738)atC>atA	p.I246I	HYAL1_ENST00000395143.2_Silent_p.I246I|HYAL1_ENST00000395144.2_Silent_p.I246I|HYAL1_ENST00000447605.2_Intron|HYAL1_ENST00000457214.2_Silent_p.I64I|HYAL1_ENST00000320295.8_Silent_p.I246I			Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1	246						extracellular space|lysosome	hyalurononglucosaminidase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	CGGGCATGTAGATGCTGGGAT	0.617000													20	63					3.5997e-14	3.83132e-14	1	1	0
NVL	4931	broad.mit.edu	37	1	224492497	224492497	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:224492497C>G	ENST00000281701.6	-	8	1025	c.766G>C	c.(766-768)Gaa>Caa	p.E256Q	NVL_ENST00000469075.1_Missense_Mutation_p.E165Q|NVL_ENST00000391875.2_Missense_Mutation_p.E150Q|NVL_ENST00000482491.1_5'UTR|NVL_ENST00000340871.4_Missense_Mutation_p.E40Q|NVL_ENST00000361463.3_Missense_Mutation_p.E150Q	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	256						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		ATCTGGAATTCTAACCCCCTG	0.318000													8	148					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678400	100678400	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:100678400G>C	ENST00000306151.4	+	3	3767	c.3703G>C	c.(3703-3705)Gag>Cag	p.E1235Q		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1235	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCAGTTCTGAGGCTAGCAC	0.517000													188	488					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66460512	66460512	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:66460512G>C	ENST00000404260.3	+	29	5822	c.5514G>C	c.(5512-5514)gtG>gtC	p.V1838V	MAST4_ENST00000403666.1_Silent_p.V1646V|MAST4_ENST00000261569.7_Silent_p.V1641V|MAST4_ENST00000405643.1_Silent_p.V1656V|MAST4_ENST00000403625.2_Silent_p.V1835V			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1838						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GTGGTGACGTGAGGGCCTCTG	0.552000													3	78					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63922762	63922762	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:63922762C>T	ENST00000443617.2	-	69	12956	c.12869G>A	c.(12868-12870)gGa>gAa	p.G4290E		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4290					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TATGATTACTCCAGCCAGGAC	0.488000													62	176					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5790579	5790579	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:5790579C>T	ENST00000328090.5	+	15	5820	c.5195C>T	c.(5194-5196)aCg>aTg	p.T1732M		NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	1732																	GCCATCCACACGCTGCAAGAT	0.488000													25	58					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20094894	20094894	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:20094894C>T	ENST00000351989.3	+	12	2526	c.2097C>T	c.(2095-2097)ggC>ggT	p.G699G	DGCR8_ENST00000383024.2_Silent_p.G666G|DGCR8_ENST00000407755.1_Silent_p.G666G	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	699	Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					GCATGTATGGCCGTGAGAGCA	0.552000													4	153					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134994509	134994509	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chrX:134994509G>C	ENST00000535938.1	+	19	2718	c.2551G>C	c.(2551-2553)Gag>Cag	p.E851Q	SAGE1_ENST00000370709.3_Missense_Mutation_p.E851Q|SAGE1_ENST00000537770.1_Missense_Mutation_p.E475Q|SAGE1_ENST00000324447.3_Missense_Mutation_p.E851Q	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	851										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					TTTGCTTGAAGAGGTACAAGG	0.308000													58	45					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229738001	229738001	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:229738001C>G	ENST00000366675.3	-	4	1001	c.913G>C	c.(913-915)Gag>Cag	p.E305Q	TAF5L_ENST00000258281.2_Missense_Mutation_p.E305Q|TAF5L_ENST00000366676.1_Missense_Mutation_p.E305Q	NM_001025247.1	NP_001020418.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	305					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				TGGTGGGGCTCTGATTTTAAC	0.468000													16	44					0	0	1	0	0
IGKV4-1	28908	broad.mit.edu	37	2	89185579	89185579	+	RNA	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:89185579C>T	ENST00000390243.2	+	0	448																											TCAGTGGCAGCGGGTCTGGGA	0.527000													26	63					0	0	1	0	0
WDR59	79726	broad.mit.edu	37	16	74972117	74972117	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:74972117G>A	ENST00000262144.6	-	8	712	c.582C>T	c.(580-582)atC>atT	p.I194I		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	194										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CCAGGCCATGGATTTTGGAGA	0.493000													28	127					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153043059	153043059	+	Missense_Mutation	SNP	C	C	T	rs17852097		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:153043059C>T	ENST00000367245.5	+	2	387	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	127			R -> G (in dbSNP:rs17852097).			nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TGGATTTTACCGCCACAGTGG	0.517000													37	86					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55752345	55752345	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:55752345C>T	ENST00000412770.2	-	10	1830	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	PPP6R1_ENST00000587283.1_Missense_Mutation_p.E422K	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	422					regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						ATGGGCGTCTCAGGGCTGCTG	0.587000													4	21					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186050343	186050343	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:186050343G>A	ENST00000271588.4	+	56	8833	c.8604G>A	c.(8602-8604)ccG>ccA	p.P2868P	HMCN1_ENST00000367492.2_Silent_p.P2868P	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2868	Ig-like C2-type 27.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGTTAGTGCCGCCAATTATCA	0.423000													4	195					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237777403	237777403	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:237777403C>T	ENST00000366574.2	+	37	5292	c.4975C>T	c.(4975-4977)Cgg>Tgg	p.R1659W	RYR2_ENST00000542537.1_Missense_Mutation_p.R1643W|RYR2_ENST00000360064.6_Missense_Mutation_p.R1657W	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1659	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCACACTCTCCGGCTCTACTC	0.498000													12	39					0	0	1	0	0
OR2A7	401427	broad.mit.edu	37	7	143955990	143955990	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:143955990G>A	ENST00000493325.1	-	1	825	c.732C>T	c.(730-732)ctC>ctT	p.L244L	RP4-798C17.6_ENST00000476560.1_RNA|RP4-798C17.6_ENST00000487102.1_RNA|RP4-798C17.6_ENST00000463561.1_RNA|RP4-798C17.6_ENST00000461843.1_RNA|RP4-545C24.1_ENST00000460955.1_RNA|RP4-798C17.6_ENST00000489488.1_RNA|ARHGEF35_ENST00000543357.1_Intron|RP4-798C17.6_ENST00000478806.1_RNA	NM_001005328.1	NP_001005328.1	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A, member 7	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	6	Melanoma(164;0.14)					CAATCACACAGAGGTGGGAGA	0.453000													39	417					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160983072	160983072	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:160983072G>A	ENST00000283249.2	-	11	1938	c.1701C>T	c.(1699-1701)agC>agT	p.S567S	ITGB6_ENST00000409967.2_Intron|ITGB6_ENST00000409872.1_Silent_p.S567S|ITGB6_ENST00000428609.2_Silent_p.S525S			P18564	ITB6_HUMAN	integrin, beta 6	567	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						CAGTCCAGCCGCTCCTGCACA	0.567000													31	91					0	0	1	0	0
C9orf153	389766	broad.mit.edu	37	9	88842265	88842265	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:88842265G>C	ENST00000376001.3	-	4	369	c.289C>G	c.(289-291)Cca>Gca	p.P97A	C9orf153_ENST00000339137.3_Intron|C9orf153_ENST00000469914.1_Intron	NM_001276366.1	NP_001263295.1	Q5TBE3	CI153_HUMAN	chromosome 9 open reading frame 153	97										breast(1)|lung(1)	2						tttatttttggagatggggtc	0.358000													18	24					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50656375	50656375	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:50656375G>A	ENST00000248846.5	-	24	5444	c.5340C>T	c.(5338-5340)ttC>ttT	p.F1780F	TUBGCP6_ENST00000439308.2_3'UTR|TUBGCP6_ENST00000491449.1_5'UTR			Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1780					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGTAGTACTTGAAGGTGTTGT	0.657000													4	108					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149206434	149206434	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr5:149206434G>C	ENST00000309241.5	+	3	483	c.451G>C	c.(451-453)Gac>Cac	p.D151H	PPARGC1B_ENST00000394320.3_Missense_Mutation_p.D151H|PPARGC1B_ENST00000403750.1_Missense_Mutation_p.D126H|PPARGC1B_ENST00000360453.4_Missense_Mutation_p.D151H	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	151					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CCCTGAGGTGGACGAGCTCTC	0.612000													18	80					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100838266	100838266	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:100838266T>G	ENST00000369208.3	-	12	3054	c.2272A>C	c.(2272-2274)Aca>Cca	p.T758P	SIM1_ENST00000262901.4_Missense_Mutation_p.T758P			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	758	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ATAACAGATGTTCCCTTGTGT	0.393000													28	113					0	0	1	0	0
C19orf26	255057	broad.mit.edu	37	19	1235876	1235876	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:1235876C>T	ENST00000590083.1	-	3	439	c.147G>A	c.(145-147)gtG>gtA	p.V49V	C19orf26_ENST00000382477.2_Silent_p.V43V|C19orf26_ENST00000215376.6_Silent_p.V43V			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	43						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATCACCACCACCAGCAGCA	0.667000										HNSCC(14;0.022)			39	147					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49195904	49195904	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr2:49195904C>T	ENST00000406846.2	-	9	906	c.787G>A	c.(787-789)Gcc>Acc	p.A263T	FSHR_ENST00000304421.4_Missense_Mutation_p.A237T|FSHR_ENST00000346173.3_Intron|FSHR_ENST00000541117.1_5'UTR|FSHR_ENST00000469138.1_5'UTR	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	263					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding	p.A263T(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCCATGAGGGCGACAAGCTTT	0.498000									Gonadal Dysgenesis, 46 XX				22	69					0	0	1	0	0
RABEP1	9135	broad.mit.edu	37	17	5238511	5238511	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:5238511C>T	ENST00000262477.6	+	4	624	c.400C>T	c.(400-402)Ctt>Ttt	p.L134F	RABEP1_ENST00000546142.2_Missense_Mutation_p.L134F|RABEP1_ENST00000408982.2_Missense_Mutation_p.L134F|RABEP1_ENST00000341923.6_Missense_Mutation_p.L134F|RABEP1_ENST00000570487.1_3'UTR|RABEP1_ENST00000537505.1_Missense_Mutation_p.L91F	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	134					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						CCAGTTCCACCTTAGGCTGGA	0.423000													17	50					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79434581	79434581	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr14:79434581C>G	ENST00000554719.1	+	11	2406	c.1915C>G	c.(1915-1917)Cga>Gga	p.R639G	NRXN3_ENST00000335750.5_Missense_Mutation_p.R639G	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	245					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CGTGGCCTCTCGAGATGGCTT	0.517000													37	74					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754481	76754481	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr18:76754481G>A	ENST00000536229.3	+	1	2800	c.2091G>A	c.(2089-2091)ccG>ccA	p.P697P	SALL3_ENST00000575389.2_Silent_p.P830P|SALL3_ENST00000537592.2_Silent_p.P830P			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	830					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGTCCTGCCCGCCCTCCCCGC	0.642000													14	40					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101194799	101194799	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:101194799G>A	ENST00000294728.2	+	5	1166	c.1065G>A	c.(1063-1065)ctG>ctA	p.L355L	VCAM1_ENST00000370119.4_Silent_p.L293L|VCAM1_ENST00000347652.2_Intron|VCAM1_ENST00000370115.1_Intron	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	355	Ig-like C2-type 4.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	ACAGCCCTCTGAGCGGGAAGG	0.522000													27	106					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463797	25463797	+	RNA	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr15:25463797G>C	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA|SNHG14_ENST00000365067.1_RNA	NR_003305.1																						TTGTCCTGAAGAGAGGTGATG	0.522000													130	413					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39090609	39090609	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:39090609G>A	ENST00000591517.1	-	22	1653	c.1625C>T	c.(1624-1626)aCt>aTt	p.T542I	MAP4K1_ENST00000423454.2_Intron|MAP4K1_ENST00000589130.1_Missense_Mutation_p.T538I|MAP4K1_ENST00000586296.1_Intron|MAP4K1_ENST00000396857.2_Missense_Mutation_p.T542I|CTB-186G2.1_ENST00000589557.1_RNA	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	542	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CACCCACGTAGTCCGGCTAGG	0.602000													47	158					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67706499	67706499	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:67706499G>A	ENST00000545606.1	+	15	4019	c.3582G>A	c.(3580-3582)ctG>ctA	p.L1194L		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	1194					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		AGAGTCCACTGATGAGTGAAT	0.428000													22	63					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17272769	17272769	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:17272769G>A	ENST00000375541.5	+	16	2221	c.2152G>A	c.(2152-2154)Gtg>Atg	p.V718M	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	718					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGCTGGCCGCGTGGAGCTCGA	0.632000													12	62					0	0	1	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	98923207	98923207	+	Splice_Site	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr10:98923207G>T	ENST00000453547.2	-	13	1547	c.1546_splice	c.e13-1	p.C516_splice	SLIT1_ENST00000266058.4_Splice_Site_p.Q91_splice|SLIT1_ENST00000456008.2_5'UTR|SLIT1_ENST00000371041.3_Splice_Site_p.Q91_splice|SLIT1_ENST00000371070.4_Splice_Site_p.Q91_splice																							TCCATCAGCTGCCTGGGGAAG	0.602000													127	340					1.45828e-52	1.57748e-52	1	1	0
SLC5A2	6524	broad.mit.edu	37	16	31501731	31501731	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr16:31501731G>T	ENST00000330498.3	+	14	1913	c.1894G>T	c.(1894-1896)Gag>Tag	p.E632*	C16orf58_ENST00000567994.1_3'UTR|C16orf58_ENST00000327237.2_3'UTR|C16orf58_ENST00000570164.1_3'UTR|SLC5A2_ENST00000564197.1_Intron	NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	632					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						TACCCAGGAGGAGGCAGCGGC	0.672000													11	19					6.40141e-05	6.53306e-05	1	1	0
CRHR2	1395	broad.mit.edu	37	7	30702317	30702317	+	Silent	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:30702317G>A	ENST00000471646.1	-	6	1107	c.690C>T	c.(688-690)atC>atT	p.I230I	CRHR2_ENST00000348438.4_Silent_p.I257I|CRHR2_ENST00000341843.4_Silent_p.I216I|CRHR2_ENST00000506074.2_Silent_p.I230I	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	230					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CACACCATCCGATGAAGAGGA	0.592000													25	69					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117240317	117240317	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:117240317G>A	ENST00000332958.2	+	11	1056	c.1040G>A	c.(1039-1041)aGa>aAa	p.R347K		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	347					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						GCAGACATAAGAAATTTTGCT	0.308000													18	63					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68698966	68698966	+	Silent	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:68698966C>G	ENST00000283916.6	-	7	746	c.648G>C	c.(646-648)ctG>ctC	p.L216L	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11D_ENST00000545541.1_Silent_p.L99L	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	216	Peptidase S1.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						TGTTATTGATCAGGCTGCCTC	0.537000													29	87					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12198305	12198305	+	Missense_Mutation	SNP	C	C	T	rs141539189	byFrequency	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:12198305C>T	ENST00000263932.2	+	14	1577	c.1355C>T	c.(1354-1356)tCg>tTg	p.S452L	TNFRSF8_ENST00000413146.2_5'UTR|TNFRSF8_ENST00000417814.2_Missense_Mutation_p.S340L|TNFRSF8_ENST00000479933.2_Intron	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	452					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGGTGCGTCGGTGACAGAA	0.627000													14	57					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36708234	36708234	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr22:36708234C>T	ENST00000216181.5	-	14	1818	c.1588G>A	c.(1588-1590)Gag>Aag	p.E530K		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	530	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity	p.E530K(1)		NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CAGCACTCCTCGTCCAGCAGG	0.637000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				28	69					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100421281	100421281	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:100421281C>T	ENST00000358173.3	-	3	864	c.396G>A	c.(394-396)gaG>gaA	p.E132E	EPHB4_ENST00000477446.1_5'UTR|EPHB4_ENST00000360620.3_Silent_p.E132E	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	132					cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGTAGGGGTTCTCCATCCAGG	0.657000													33	55					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66325221	66325221	+	RNA	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:66325221G>A	ENST00000513398.1	+	0	1046				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						CCGTGTGGGTGAGCCCAGCAT	0.632000													7	24					0	0	1	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841624	8841624	+	Silent	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:8841624C>T	ENST00000324060.2	+	1	309	c.234C>T	c.(232-234)atC>atT	p.I78I		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGGTCACCATCCCCAAGATGG	0.547000													32	99					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19283202	19283202	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:19283202A>G	ENST00000308406.5	+	3	726	c.340A>G	c.(340-342)Atc>Gtc	p.I114V	MAPK7_ENST00000571657.1_Intron|MAPK7_ENST00000299612.7_Intron|MAPK7_ENST00000395604.3_Missense_Mutation_p.I114V|MAPK7_ENST00000395602.4_Missense_Mutation_p.I114V	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	114	Protein kinase.|Required for binding to MAP2K5 (By similarity).				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					ACACGACAACATCATCGCCAT	0.522000													40	102					0	0	1	0	0
EPHX1	2052	broad.mit.edu	37	1	226032238	226032238	+	Silent	SNP	C	C	G			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:226032238C>G	ENST00000366837.4	+	8	1276	c.1080C>G	c.(1078-1080)ctC>ctG	p.L360L	EPHX1_ENST00000272167.5_Silent_p.L360L|RP11-285F7.2_ENST00000424332.1_RNA	NM_000120.3	NP_000111.1	P07099	HYEP_HUMAN	epoxide hydrolase 1, microsomal (xenobiotic)	360					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.197)					ACGTCATGCTCTACTGGACAA	0.572000													4	89					0	0	1	0	0
CCL19	6363	broad.mit.edu	37	9	34691101	34691101	+	Silent	SNP	G	G	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr9:34691101G>C	ENST00000311925.2	-	1	173	c.36C>G	c.(34-36)ctC>ctG	p.L12L	CCL19_ENST00000378800.3_Silent_p.L12L	NM_006274.2	NP_006265.1	Q99731	CCL19_HUMAN	chemokine (C-C motif) ligand 19	12					activation of JUN kinase activity|cell communication|cell maturation|establishment of T cell polarity|immune response|immunological synapse formation|inflammatory response|interleukin-12 secretion|myeloid dendritic cell chemotaxis|negative regulation of leukocyte apoptosis|positive regulation of Cdc42 GTPase activity|positive regulation of dendritic cell antigen processing and presentation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glycoprotein biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of neutrophil chemotaxis|positive regulation of NF-kappaB import into nucleus|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of receptor-mediated endocytosis|positive regulation of T cell proliferation|positive regulation of T-helper 1 cell differentiation|positive regulation of tumor necrosis factor production|regulation of cell projection assembly|release of sequestered calcium ion into cytosol|response to nitric oxide|response to prostaglandin E stimulus|response to virus|T cell costimulation	extracellular space	CCR10 chemokine receptor binding|CCR7 chemokine receptor binding|chemokine activity					all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		GGGAAGTCCAGAGAACCAGCA	0.602000													14	16					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55958791	55958791	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:55958791G>A	ENST00000263923.4	-	22	3357	c.3062C>T	c.(3061-3063)tCg>tTg	p.S1021L		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1021	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TACCTTTCGCGATGCCAAGAA	0.458000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			16	60					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135272633	135272633	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:135272633C>T	ENST00000285968.6	+	10	1392	c.1366C>T	c.(1366-1368)Cat>Tat	p.H456Y	NUP205_ENST00000440390.2_Intron	NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	456					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						GAACCCTTTTCATCTGGAGCT	0.433000													18	75					0	0	1	0	0
CBX2	84733	broad.mit.edu	37	17	77758764	77758764	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:77758764G>A	ENST00000310942.4	+	5	1626	c.1522G>A	c.(1522-1524)Gtc>Atc	p.V508I		NM_005189.2	NP_005180.1	Q14781	CBX2_HUMAN	chromobox homolog 2	508					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TGTCACCGACGTCACTGCCAA	0.622000													25	57					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130897293	130897293	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr12:130897293C>T	ENST00000261655.4	-	15	2855	c.2692G>A	c.(2692-2694)Gaa>Aaa	p.E898K		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	898	SH3 2.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCACAGGTTTCCCCACGGTAG	0.438000													19	61					0	0	1	0	0
INTS6-AS1	100507398	broad.mit.edu	37	13	52035196	52035196	+	RNA	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr13:52035196C>A	ENST00000594959.1	+	0	411				INTS6-AS1_ENST00000595997.1_RNA|INTS6-AS1_ENST00000593429.1_RNA|INTS6-AS1_ENST00000602089.1_RNA|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000601572.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000601318.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|RPS4XP16_ENST00000595905.1_RNA|INTS6-AS1_ENST00000601034.1_RNA|INTS6-AS1_ENST00000597745.1_RNA|INTS6-AS1_ENST00000594604.1_RNA|INTS6-AS1_ENST00000594488.1_RNA|INTS6-AS1_ENST00000599315.1_RNA|INTS6-AS1_ENST00000598864.1_RNA|INTS6-AS1_ENST00000594358.1_RNA|INTS6-AS1_ENST00000600477.1_RNA|INTS6-AS1_ENST00000593928.1_RNA|INTS6-AS1_ENST00000593709.1_RNA|INTS6-AS1_ENST00000596303.1_RNA|INTS6-AS1_ENST00000434512.1_RNA|INTS6-AS1_ENST00000596180.1_RNA																							CGACACTGGTCACCTGTGTAT	0.453000													4	32					0.00024832	0.000252131	1	1	0
C1QC	714	broad.mit.edu	37	1	22973835	22973835	+	Silent	SNP	C	C	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:22973835C>A	ENST00000374639.3	+	3	415	c.297C>A	c.(295-297)ccC>ccA	p.P99P	C1QC_ENST00000374640.4_Silent_p.P99P|C1QC_ENST00000374637.1_Silent_p.P99P	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	99	Collagen-like.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAGGGGTGCCCGGCCCCATGG	0.647000													20	64					4.96729e-08	5.2032e-08	1	1	0
STK38	11329	broad.mit.edu	37	6	36492197	36492197	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr6:36492197A>C	ENST00000229812.7	-	4	512	c.227T>G	c.(226-228)tTt>tGt	p.F76C		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	76	Interaction with S100B.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CAAACGAAGAAACTCTGTTTC	0.398000													27	66					0	0	1	0	0
PCSK9	255738	broad.mit.edu	37	1	55509581	55509582	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:55509581_55509582delAG	ENST00000302118.5	+	2	563_564	c.273_274delAG	c.(271-276)tcagfs	p.SE91fs	PCSK9_ENST00000452118.2_Frame_Shift_Del_p.SE91fs|PCSK9_ENST00000543384.1_Intron	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	91					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						TCTCGCAGTCAGAGCGCACTGC	0.624													15	60	---	---	---	---					
CACNA1E	777	broad.mit.edu	37	1	181759648	181759651	+	Frame_Shift_Del	DEL	ATGG	ATGG	-			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr1:181759648_181759651delATGG	ENST00000526775.1	+	43	5962_5965	c.5797_5800delATGG	c.(5797-5802)acfs	p.MD1933fs	CACNA1E_ENST00000358338.5_Frame_Shift_Del_p.MD1884fs|CACNA1E_ENST00000357570.5_Frame_Shift_Del_p.MD1903fs|CACNA1E_ENST00000367570.1_Frame_Shift_Del_p.MD1952fs|CACNA1E_ENST00000367573.2_Frame_Shift_Del_p.MD1952fs|CACNA1E_ENST00000367567.4_Frame_Shift_Del_p.MD1559fs|CACNA1E_ENST00000360108.3_Frame_Shift_Del_p.MD1933fs	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1952					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GTTGGCTTGTATGGACCCCGCCGA	0.495													14	50	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187521139	187521140	+	Frame_Shift_Ins	INS	-	-	TACT			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:187521139_187521140insTACT	ENST00000441802.2	-	22	12224_12225	c.12015_12016insAGTA	c.(12013-12018)gtctccfs	p.S4006fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4006	Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAGCCTGGAGATACATCCACCG	0.540										HNSCC(5;0.00058)			45	109	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187538959	187538960	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr4:187538959_187538960insA	ENST00000441802.2	-	10	8989_8990	c.8780_8781insT	c.(8779-8781)gagfs	p.E2927fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2927	Cadherin 27.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CATCCTCACTCACAGTCCCTTT	0.470										HNSCC(5;0.00058)			41	101	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	152012225	152012228	+	Frame_Shift_Del	DEL	TCTC	TCTC	-			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr7:152012225_152012228delTCTC	ENST00000355193.2	-	4	803_806	c.585_588delGAGA	c.(583-588)cafs	p.QR195fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.QR195fs					lysine (K)-specific methyltransferase 2C																		CTGCTTACTTTCTCTGTCCTCTTT	0.333													85	56	---	---	---	---					
PPP2CB	5516	broad.mit.edu	37	8	30669897	30669898	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr8:30669897_30669898insC	ENST00000221138.4	-	1	490_491	c.40_41insG	c.(40-42)cgafs	p.R14fs	PPP2CB_ENST00000520500.1_Intron|PPP2CB_ENST00000518564.1_Frame_Shift_Ins_p.R14fs	NM_001009552.1	NP_001009552.1	P62714	PP2AB_HUMAN	protein phosphatase 2, catalytic subunit, beta isozyme	14					protein dephosphorylation	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex|spindle pole	metal ion binding			breast(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	9				KIRC - Kidney renal clear cell carcinoma(542;0.095)|Kidney(114;0.114)	Vitamin E(DB00163)	CAGCTGCTCGACCCACTGGTCC	0.708													10	26	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738795	102738796	+	RNA	INS	-	-	T	rs33924686	by1000genomes	TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr11:102738795_102738796insT	ENST00000532855.1	-	0	725_726							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.N211fs*20(2)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGGAACAAGTGGTGCCTAAGAA	0.416													6	8	---	---	---	---					
OR3A2	4995	broad.mit.edu	37	17	3181557	3181559	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:3181557_3181559delTGA	ENST00000408891.2	-	1	709_711	c.671_673delTCA	c.(670-675)act>a	p.IT224del		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	224					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CTGTAGGCAGTGATGATGAGAAC	0.567													23	90	---	---	---	---					
KRT10	3858	broad.mit.edu	37	17	38978766	38978768	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:38978766_38978768delTCC	ENST00000269576.5	-	1	79_81	c.70_72delGGA	c.(70-72)del	p.G24del	TMEM99_ENST00000496847.1_Intron|TMEM99_ENST00000301665.3_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	24	Gly-rich.|Head.			Missing (in Ref. 1; AAA60544).	epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				ctcctccacatcctcctcctcct	0.547													7	52	---	---	---	---					
NAGLU	4669	broad.mit.edu	37	17	40693145	40693146	+	Frame_Shift_Del	DEL	CA	CA	-	rs118204025		TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:40693145_40693146delCA	ENST00000225927.2	+	5	1043_1044	c.942_943delCA	c.(940-945)ttatfs	p.FN314fs	RP11-400F19.8_ENST00000585572.1_RNA	NM_000263.3	NP_000254.2	P54802	ANAG_HUMAN	N-acetylglucosaminidase, alpha	314			F -> L (in MPS3B).			lysosome	alpha-N-acetylglucosaminidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	12		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CCGACACTTTCAATGAGATGCA	0.584													52	98	---	---	---	---					
TUBD1	51174	broad.mit.edu	37	17	57958381	57958382	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:57958381_57958382insA	ENST00000325752.3	-	4	687_688	c.410_411insT	c.(409-411)tatfs	p.Y137fs	TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000394239.3_Frame_Shift_Ins_p.Y137fs|TUBD1_ENST00000340993.6_Frame_Shift_Ins_p.Y137fs|TUBD1_ENST00000376094.4_Frame_Shift_Ins_p.Y137fs|TUBD1_ENST00000591611.1_Intron|TUBD1_ENST00000539018.1_Intron|TUBD1_ENST00000592426.1_Frame_Shift_Ins_p.Y137fs	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	137					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TCATTATGATGAAAAAACCACT	0.396													43	170	---	---	---	---					
PPM1D	8493	broad.mit.edu	37	17	58740643	58740643	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr17:58740643delA	ENST00000305921.3	+	6	1780	c.1548delA	c.(1546-1548)tcfs	p.S516fs		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	516					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TGAAGATGTCAACTCCTGGCC	0.393											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	32	81	---	---	---	---					
UPF1	5976	broad.mit.edu	37	19	18976359	18976379	+	Splice_Site	DEL	CTGTCTTTCAGGGCGAGGCAC	CTGTCTTTCAGGGCGAGGCAC	-			TCGA-BA-A6DJ-01A-11D-A30E-08	TCGA-BA-A6DJ-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e33eddc-c0eb-4f34-a43a-37e8248206aa	00dcd698-1f0f-4cd5-9c65-c3b0fbaf2d27	g.chr19:18976359_18976379delCTGTCTTTCAGGGCGAGGCAC	ENST00000262803.5	+	22	3291_3301	c.3019_splice	c.e22-1	p.1007_splice	UPF1_ENST00000599848.1_Splice_Site_p.1018_splice	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	1018					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						CCCTGGACTGCTGTCTTTCAGGGCGAGGCACCCCGAAAGGC	0.633													20	87	---	---	---	---					
