Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NEB	4703	broad.mit.edu	37	2	152501079	152501079	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr2:152501079C>A	ENST00000427231.2	-	56	7749	c.7547G>T	c.(7546-7548)cGa>cTa	p.R2516L	NEB_ENST00000604864.1_Missense_Mutation_p.R2516L|NEB_ENST00000409198.1_Missense_Mutation_p.R2516L|NEB_ENST00000172853.10_Missense_Mutation_p.R2516L|NEB_ENST00000397345.3_Missense_Mutation_p.R2516L|NEB_ENST00000603639.1_Missense_Mutation_p.R2516L	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2516					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATAACCCATTCGGTAGAGTTT	0.388000													3	126					0.115264	0.124229	0.115264	1	0
ARNT2	9915	broad.mit.edu	37	15	80845046	80845046	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:80845046G>A	ENST00000533983.1	+	11	1326	c.987G>A	c.(985-987)cgG>cgA	p.R329R	ARNT2_ENST00000303329.4_Silent_p.R340R|ARNT2_ENST00000527771.1_Silent_p.R329R			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	340	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			TCTTATCCCGGCATAACTCCG	0.483000													5	210					0	0	0.184627	0	0
GNB2	2783	broad.mit.edu	37	7	100275401	100275401	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr7:100275401G>A	ENST00000303210.4	+	7	939	c.457G>A	c.(457-459)Gat>Aat	p.D153N	GNB2_ENST00000393924.1_Missense_Mutation_p.D153N|GNB2_ENST00000427895.1_Missense_Mutation_p.D53N|GNB2_ENST00000419828.1_Missense_Mutation_p.D53N|GNB2_ENST00000424361.1_Missense_Mutation_p.D109N|GNB2_ENST00000436220.1_Missense_Mutation_p.D109N|GNB2_ENST00000393926.1_Missense_Mutation_p.D153N	NM_005273.3	NP_005264.2	P62879	GBB2_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 2	153					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			endometrium(1)|lung(3)|ovary(2)|prostate(1)	7	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				CCGCTTCCTGGATGACAACCA	0.627000													46	42					0	0	0.870114	0	0
PLG	5340	broad.mit.edu	37	6	161155067	161155067	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:161155067G>A	ENST00000308192.9	+	13	1691	c.1628G>A	c.(1627-1629)tGc>tAc	p.C543Y		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	543	Kringle 5.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGTCCCTGGTGCTACACGACA	0.473000													30	31					0	0	0.750413	0	0
ACTN1	87	broad.mit.edu	37	14	69349260	69349260	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr14:69349260G>A	ENST00000193403.6	-	16	2251	c.1868C>T	c.(1867-1869)gCc>gTc	p.A623V	ACTN1_ENST00000376839.3_Missense_Mutation_p.A558V|ACTN1_ENST00000394419.4_Missense_Mutation_p.A623V|ACTN1_ENST00000538545.2_Missense_Mutation_p.A623V|ACTN1_ENST00000438964.2_Missense_Mutation_p.A623V	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	623	Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding	p.A623V(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CTGCTGTCGGGCATGCTCCTC	0.612000													5	129					0	0	0.184627	0	0
RPAP1	26015	broad.mit.edu	37	15	41828763	41828763	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:41828763T>C	ENST00000304330.4	-	3	382	c.266A>G	c.(265-267)gAg>gGg	p.E89G	RPAP1_ENST00000561603.1_Missense_Mutation_p.E89G	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	89						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TTCTGGGTCCTCATCCTCAGG	0.527000													3	216					0	0	0.115264	0	0
GABBR1	2550	broad.mit.edu	37	6	29572395	29572395	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:29572395C>T	ENST00000377034.4	-	22	2923	c.2588G>A	c.(2587-2589)cGa>cAa	p.R863Q	GABBR1_ENST00000355973.3_Missense_Mutation_p.R746Q|GABBR1_ENST00000376977.3_3'UTR|GABBR1_ENST00000377012.4_Missense_Mutation_p.R746Q|GABBR1_ENST00000377016.4_Missense_Mutation_p.R801Q	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	863					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.R863Q(1)		endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	CCATTCCCCTCGGGTGATCAG	0.592000													4	214					0	0	0.150653	0	0
COL3A1	1281	broad.mit.edu	37	2	189854843	189854843	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr2:189854843C>T	ENST00000304636.3	+	9	882	c.712C>T	c.(712-714)Cga>Tga	p.R238*	COL3A1_ENST00000317840.5_Nonsense_Mutation_p.R238*	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	238	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.R238*(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAGACCCGGACGACCTGGAGA	0.383000													35	73					0	0	0.804634	0	0
NUP93	9688	broad.mit.edu	37	16	56872869	56872869	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:56872869G>T	ENST00000564887.1	+	17	2284	c.1655G>T	c.(1654-1656)aGg>aTg	p.R552M	NUP93_ENST00000542526.1_Missense_Mutation_p.R552M|NUP93_ENST00000569842.1_Missense_Mutation_p.R675M|NUP93_ENST00000308159.5_Missense_Mutation_p.R675M	NM_001242795.1	NP_001229724.1	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	675					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TTCAGGTATAGGGCTCAAGGA	0.393000													4	186					0.00909568	0.0100259	0.150653	1	0
RENBP	5973	broad.mit.edu	37	X	153209359	153209359	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chrX:153209359C>T	ENST00000412763.1	-	4	446	c.277G>A	c.(277-279)Gca>Aca	p.A93T	RENBP_ENST00000369997.3_Missense_Mutation_p.A79T|RENBP_ENST00000393700.3_Missense_Mutation_p.A93T			P51606	RENBP_HUMAN	renin binding protein	93					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GCTTTTGCTGCGTCCAGAAGC	0.577000													6	0					0	0	0.217242	0	0
HMGCR	3156	broad.mit.edu	37	5	74651207	74651207	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr5:74651207C>A	ENST00000287936.4	+	14	1896	c.1740C>A	c.(1738-1740)agC>agA	p.S580R	HMGCR_ENST00000343975.5_Missense_Mutation_p.S527R|HMGCR_ENST00000511206.1_Missense_Mutation_p.S580R	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	580	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GAGGTGCCAGCAGCCGAGTCC	0.493000													94	160					8.45e-40	1.01191e-39	0.870114	1	0
ACER1	125981	broad.mit.edu	37	19	6309770	6309770	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:6309770G>A	ENST00000301452.4	-	4	503	c.426C>T	c.(424-426)aaC>aaT	p.N142N		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	142						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						GGGCGTAGGCGTTGACCGTGG	0.607000													81	109					0	0	0.870114	0	0
C11orf16	56673	broad.mit.edu	37	11	8942935	8942935	+	Silent	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:8942935C>A	ENST00000326053.5	-	6	1438	c.1332G>T	c.(1330-1332)ccG>ccT	p.P444P	C11orf16_ENST00000525780.1_Intron	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	444										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		CTTCCCCTGGCGGGGTCCGCG	0.517000													4	284					0.00909568	0.0100259	0.150653	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	131					0	0	0.115264	0	0
SPAG1	6674	broad.mit.edu	37	8	101206583	101206583	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:101206583C>T	ENST00000520508.1	+	10	1467	c.1183C>T	c.(1183-1185)Cgt>Tgt	p.R395C	SPAG1_ENST00000388798.2_Intron|SPAG1_ENST00000251809.3_Intron|SPAG1_ENST00000520643.1_Missense_Mutation_p.R395C			Q07617	SPAG1_HUMAN	sperm associated antigen 1	0					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TACAGAAATTCGTAATCTATC	0.328000													3	12					0	0	0.115264	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86324547	86324547	+	Missense_Mutation	SNP	T	T	A	rs147197492		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:86324547T>A	ENST00000369622.3	-	11	2299	c.1799A>T	c.(1798-1800)cAt>cTt	p.H600L	RP11-321N4.5_ENST00000503906.1_Intron|SYNCRIP_ENST00000355238.6_Intron	NM_001159675.1|NM_006372.4	NP_001153147.1|NP_006363.4	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	600					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GTTACCAGAATGATCACCACC	0.478000													90	113					0	0	0.870114	0	0
DAGLA	747	broad.mit.edu	37	11	61488167	61488167	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:61488167G>A	ENST00000257215.5	+	3	228	c.112G>A	c.(112-114)Gtg>Atg	p.V38M		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	38					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		GATCCTGTCCGTGGTGCTCTT	0.637000													48	60					0	0	0.870114	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41102895	41102895	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:41102895C>T	ENST00000355341.4	+	6	1267	c.766C>T	c.(766-768)Ctg>Ttg	p.L256L	ZFYVE19_ENST00000336455.5_Silent_p.L246L|ZFYVE19_ENST00000299173.10_Silent_p.L256L|ZFYVE19_ENST00000564258.1_Silent_p.L81L|ZFYVE19_ENST00000570108.1_Silent_p.L233L	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	256							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GACACAGGATCTGCTAACGCA	0.592000													2	8					0	0	0.115264	0	0
DMWD	1762	broad.mit.edu	37	19	46289911	46289911	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:46289911C>T	ENST00000270223.6	-	3	888	c.843G>A	c.(841-843)gcG>gcA	p.A281A	DMWD_ENST00000377735.3_Silent_p.A281A	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	281					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCTCACCCACCGCCCACTTGG	0.677000													41	54					0	0	0.827153	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181621	140181621	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr5:140181621C>G	ENST00000522353.2	+	1	839	c.839C>G	c.(838-840)tCt>tGt	p.S280C	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.S280C|PCDHA2_ENST00000520672.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGCGTATTCTTTCAATACG	0.388000													69	78					0	0	0.870114	0	0
ABCG1	9619	broad.mit.edu	37	21	43704767	43704767	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr21:43704767G>A	ENST00000398437.1	+	8	1418	c.1270G>A	c.(1270-1272)Gcc>Acc	p.A424T	ABCG1_ENST00000398457.2_Missense_Mutation_p.A280T|ABCG1_ENST00000361802.2_Missense_Mutation_p.A278T|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000343687.3_Missense_Mutation_p.A289T|ABCG1_ENST00000398449.3_Missense_Mutation_p.A278T|ABCG1_ENST00000347800.2_Missense_Mutation_p.A275T|ABCG1_ENST00000340588.4_Missense_Mutation_p.A386T			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	278	ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	CCAGCCCAGCGCCAAACTCTT	0.637000													7	209					0	0	0.307466	0	0
IFRD2	7866	broad.mit.edu	37	3	50326114	50326114	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr3:50326114C>T	ENST00000436390.1	-	13	1549	c.1052G>A	c.(1051-1053)cGc>cAc	p.R351H	IFRD2_ENST00000417626.2_Missense_Mutation_p.R351H|IFRD2_ENST00000336089.4_Missense_Mutation_p.R517H|IFRD2_ENST00000429673.2_Missense_Mutation_p.R415H			Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	415							binding			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AAAGCCGAAGCGCACTATCTC	0.597000													18	2					0	0	0.520397	0	0
FZD3	7976	broad.mit.edu	37	8	28384970	28384970	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:28384970C>A	ENST00000240093.3	+	5	1171	c.693C>A	c.(691-693)ttC>ttA	p.F231L	FZD3_ENST00000537916.1_Missense_Mutation_p.F231L	NM_017412.3	NP_059108.1	Q9NPG1	FZD3_HUMAN	frizzled family receptor 3	231					canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(15)|ovary(1)|prostate(1)|skin(1)	41		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TCACAAGATTCCGTTATCCTG	0.353000													86	280					5.72486e-32	6.6905e-32	0.870114	1	0
PDE4DIP	9659	broad.mit.edu	37	1	145075769	145075769	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:145075769G>A	ENST00000369359.4	-	1	132	c.94C>T	c.(94-96)Cgg>Tgg	p.R32W	PDE4DIP_ENST00000369345.4_Missense_Mutation_p.R32W|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R32W|PDE4DIP_ENST00000369348.3_Missense_Mutation_p.R32W			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCCCGGACCGGTAAGGCGTG	0.716000			T	PDGFRB	MPD								4	209					0	0	0.217242	0	0
FAT4	79633	broad.mit.edu	37	4	126372965	126372965	+	Silent	SNP	A	A	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:126372965A>G	ENST00000394329.3	+	9	10807	c.10794A>G	c.(10792-10794)ggA>ggG	p.G3598G	FAT4_ENST00000335110.5_Silent_p.G1896G	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3598	Cadherin 34.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTTCCACAGGAACTGTGCATA	0.428000													125	155					0	0	0.870114	0	0
FBXW7	55294	broad.mit.edu	37	4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	rs149680468		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:153247289G>C	ENST00000281708.4	-	10	2742	c.1513C>G	c.(1513-1515)Cgc>Ggc	p.R505G	FBXW7_ENST00000393956.3_Missense_Mutation_p.R329G|FBXW7_ENST00000603548.1_Missense_Mutation_p.R505G|FBXW7_ENST00000263981.5_Missense_Mutation_p.R425G|FBXW7_ENST00000603841.1_Missense_Mutation_p.R505G|FBXW7_ENST00000296555.5_Missense_Mutation_p.R387G	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	505			R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R505C(60)|p.R505G(18)|p.R425C(14)|p.R266C(13)|p.R425G(9)|p.R266G(9)|p.R387G(6)|p.R387C(3)|p.R505S(3)|p.R387S(1)|p.?(1)|p.R425S(1)|p.R266S(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								100	120					0	0	0.870114	0	0
RASGRP3	25780	broad.mit.edu	37	2	33745738	33745738	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr2:33745738G>A	ENST00000403687.3	+	6	1095	c.355G>A	c.(355-357)Gac>Aac	p.D119N	RASGRP3_ENST00000402538.3_Missense_Mutation_p.D119N|RASGRP3_ENST00000407811.1_Missense_Mutation_p.D119N	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	119	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					CAGCCTCATCGACATATCCAG	0.453000													4	216					0	0	0.150653	0	0
CFHR3	10878	broad.mit.edu	37	1	196757510	196757510	+	Missense_Mutation	SNP	G	G	A	rs5002712		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:196757510G>A	ENST00000471440.2	+	4	669	c.595G>A	c.(595-597)Gca>Aca	p.A199T	CFHR3_ENST00000391985.3_Intron|CFHR3_ENST00000367425.4_Missense_Mutation_p.A199T					complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						TGGATGGTCAGCACAACCAAT	0.303000													4	221					0	0	0.278610	0	0
FAM179B	23116	broad.mit.edu	37	14	45433445	45433445	+	Silent	SNP	A	A	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr14:45433445A>G	ENST00000361462.2	+	1	2004	c.1821A>G	c.(1819-1821)ggA>ggG	p.G607G	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000382233.2_Silent_p.G607G|FAM179B_ENST00000361577.3_Silent_p.G607G			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	607							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						TGGCACATGGAGCAGATACGG	0.493000													4	212					0	0	0.150653	0	0
PEX2	5828	broad.mit.edu	37	8	77896111	77896111	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:77896111G>T	ENST00000419564.2	-	4	768	c.304C>A	c.(304-306)Caa>Aaa	p.Q102K	PEX2_ENST00000357039.4_Missense_Mutation_p.Q102K|PEX2_ENST00000522527.1_Missense_Mutation_p.Q102K|PEX2_ENST00000520103.1_Missense_Mutation_p.Q102K	NM_001172087.1	NP_001165558.1	P28328	PEX2_HUMAN	peroxisomal biogenesis factor 2	102					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	14						CAGATTTTTTGATTTTTACTG	0.373000													115	57					4.35912e-55	5.28544e-55	0.870114	1	0
ITGAL	3683	broad.mit.edu	37	16	30525152	30525152	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:30525152C>T	ENST00000356798.6	+	25	3027	c.2847C>T	c.(2845-2847)gtC>gtT	p.V949V	ITGAL_ENST00000358164.5_Silent_p.V865V|ITGAL_ENST00000433423.2_Silent_p.V183V	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	949					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TCCACCAAGTCAAGCACATGT	0.507000													57	74					0	0	0.870114	0	0
RAB2A	5862	broad.mit.edu	37	8	61496839	61496839	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:61496839G>A	ENST00000262646.7	+	4	610	c.259G>A	c.(259-261)Gat>Aat	p.D87N	RAB2A_ENST00000530071.1_3'UTR|RAB2A_ENST00000529579.1_Missense_Mutation_p.D87N|RAB2A_ENST00000531289.1_Missense_Mutation_p.D63N	NM_002865.2	NP_002856.1	P61019	RAB2A_HUMAN	RAB2A, member RAS oncogene family	87					ER to Golgi vesicle-mediated transport|protein transport|small GTPase mediated signal transduction	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|melanosome	GDP binding|GTP binding|GTPase activity	p.D87Y(1)		endometrium(1)|large_intestine(1)|lung(4)	6			BRCA - Breast invasive adenocarcinoma(89;0.0805)			ACTAGTTTACGATATTACACG	0.378000													6	375					0	0	0.217242	0	0
MUC5B	727897	broad.mit.edu	37	11	1263410	1263410	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:1263410C>T	ENST00000447027.1	+	31	5367	c.5309C>T	c.(5308-5310)aCg>aTg	p.T1770M	MUC5B_ENST00000529681.1_Missense_Mutation_p.T1767M			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1767	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGGACAGAGACGACAATGAGC	0.617000													31	41					0	0	0.750413	0	0
PRDM9	56979	broad.mit.edu	37	5	23527575	23527575	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr5:23527575G>C	ENST00000296682.3	+	11	2560	c.2378G>C	c.(2377-2379)aGt>aCt	p.S793T		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	793					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AACCTCCTCAGTCACCAGAGG	0.562000										HNSCC(3;0.000094)			5	581					0	0	0.184627	0	0
TBC1D14	57533	broad.mit.edu	37	4	7016236	7016236	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:7016236C>T	ENST00000409757.4	+	12	1833	c.1709C>T	c.(1708-1710)gCg>gTg	p.A570V	TBC1D14_ENST00000448507.1_Missense_Mutation_p.A570V|TBC1D14_ENST00000446947.2_Missense_Mutation_p.A217V|TBC1D14_ENST00000451522.2_Missense_Mutation_p.A290V|TBC1D14_ENST00000410031.1_Missense_Mutation_p.A342V	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	570	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						AAATTATTTGCGCATTTCAAG	0.358000													3	66					0	0	0.184627	0	0
KCNT2	343450	broad.mit.edu	37	1	196227545	196227545	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:196227545C>T	ENST00000367433.5	-	25	3019	c.2918G>A	c.(2917-2919)cGc>cAc	p.R973H	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.R931H|KCNT2_ENST00000294725.8_Missense_Mutation_p.R997H|KCNT2_ENST00000451324.2_3'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	997						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGTTGAGTTGCGGTGGTTGCT	0.483000													74	100					0	0	0.870114	0	0
CRCT1	54544	broad.mit.edu	37	1	152487926	152487926	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:152487926C>T	ENST00000368790.3	+	2	140	c.67C>T	c.(67-69)Ccg>Tcg	p.P23S		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	23										lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGccccgctccgtgtcccgc	0.706000													19	13					0	0	0.557998	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162620	90162620	+	RNA	SNP	T	T	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:90162620T>G	ENST00000564451.1	+	0	1973																											CTAGGTAAAGTGGGGAAGCAG	0.483000													3	207					0	0	0.150653	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793355	65793355	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:65793355C>T	ENST00000312106.5	-	1	633	c.496G>A	c.(496-498)Gtg>Atg	p.V166M		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	166	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding	p.V166M(2)		breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						TGGTGGGGCACGCCAGAGGAA	0.582000													71	75					0	0	0.870114	0	0
CCDC114	93233	broad.mit.edu	37	19	48800379	48800379	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:48800379C>T	ENST00000315396.7	-	14	2549	c.1867G>A	c.(1867-1869)Gaa>Aaa	p.E623K		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	623	Ser-rich.									cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		TCTGTGTTTTCTCCGCCCCTG	0.667000													5	234					0	0	0.217242	0	0
ADAL	161823	broad.mit.edu	37	15	43641114	43641114	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:43641114C>T	ENST00000422466.2	+	11	1217	c.643C>T	c.(643-645)Caa>Taa	p.Q215*	ADAL_ENST00000562188.1_Nonsense_Mutation_p.Q215*|ADAL_ENST00000428046.3_Nonsense_Mutation_p.Q188*|ADAL_ENST00000389651.4_Nonsense_Mutation_p.Q215*			Q6DHV7	ADAL_HUMAN	adenosine deaminase-like	215					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding			endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)	7		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GATTCCAAACCAAAAAAAAGA	0.453000													36	61					0	0	0.827153	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:90161902A>G	ENST00000564451.1	+	0	1255				TUBB8P7_ENST00000567960.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													4	52					0	0	0.184627	0	0
CCDC40	55036	broad.mit.edu	37	17	78013852	78013852	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:78013852C>T	ENST00000397545.4	+	3	362	c.335C>T	c.(334-336)aCg>aTg	p.T112M	CCDC40_ENST00000269318.5_Missense_Mutation_p.T112M|CCDC40_ENST00000374877.3_Missense_Mutation_p.T112M|CCDC40_ENST00000374876.4_Missense_Mutation_p.T112M	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	112					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTGCAGATACGACTTACCCG	0.527000													89	115					0	0	0.870114	0	0
OCIAD2	132299	broad.mit.edu	37	4	48894854	48894854	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:48894854G>A	ENST00000508632.1	-	6	550	c.318C>T	c.(316-318)tgC>tgT	p.C106C	OCIAD2_ENST00000508069.2_5'UTR|OCIAD2_ENST00000273860.4_Intron	NM_001014446.1	NP_001014446.1	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2	106	OCIA.					endosome				kidney(1)|lung(3)|skin(1)|urinary_tract(1)	6						ATTTACTCTGGCATACTCCTA	0.418000													5	324					0	0	0.184627	0	0
AP2A2	161	broad.mit.edu	37	11	994108	994108	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:994108C>T	ENST00000448903.2	+	14	1960	c.1819C>T	c.(1819-1821)Cgg>Tgg	p.R607W	AP2A2_ENST00000534328.1_Intron|AP2A2_ENST00000332231.5_Missense_Mutation_p.R608W	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	607					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		ATTCCCGGAGCGGGAGTCCTC	0.622000													68	111					0	0	0.870114	0	0
AES	166	broad.mit.edu	37	19	3054133	3054133	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:3054133C>T	ENST00000221561.8	-	6	737	c.558G>A	c.(556-558)ctG>ctA	p.L186L	AES_ENST00000586839.1_Silent_p.L63L|AES_ENST00000327141.4_Silent_p.L119L|AES_ENST00000592330.1_Intron	NM_198969.1	NP_945320.1	Q08117	AES_HUMAN	amino-terminal enhancer of split	119	CCN domain.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			lung(8)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGATAGAGTTCAGCTCGGGAG	0.657000													14	17					0	0	0.479597	0	0
EFCAB5	374786	broad.mit.edu	37	17	28417554	28417554	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:28417554G>A	ENST00000394835.3	+	20	3991	c.3799G>A	c.(3799-3801)Gat>Aat	p.D1267N	EFCAB5_ENST00000394832.2_Intron|EFCAB5_ENST00000320856.5_Missense_Mutation_p.D1143N|RP11-1148O4.2_ENST00000582938.1_RNA	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	1267							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GGGAGTCCTCGATTTTAACAT	0.428000													90	109					0	0	0.870114	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79966949	79966949	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:79966949G>T	ENST00000306729.7	+	8	1067	c.970G>T	c.(970-972)Gtg>Ttg	p.V324L	ASPSCR1_ENST00000580534.1_Missense_Mutation_p.V247L|ASPSCR1_ENST00000306739.4_Missense_Mutation_p.V324L	NM_001251888.1	NP_001238817.1	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region, candidate 1	324	Interaction with GLUT4 (By similarity).						protein binding		ASPSCR1/TFE3(167)	breast(2)|large_intestine(2)	4	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GGAGCCGGTGGTGTGCCACCC	0.721000			T	TFE3	alveolar soft part sarcoma								10	3					3.07112e-06	3.50469e-06	0.387290	1	0
MACF1	23499	broad.mit.edu	37	1	39907692	39907692	+	Silent	SNP	C	C	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:39907692C>G	ENST00000564288.1	+	75	19518	c.18741C>G	c.(18739-18741)ctC>ctG	p.L6247L	MACF1_ENST00000372915.3_Silent_p.L6146L|MACF1_ENST00000567887.1_Silent_p.L6284L|MACF1_ENST00000361689.2_Silent_p.L4188L|MACF1_ENST00000545844.1_Silent_p.L4188L|MACF1_ENST00000289893.4_Silent_p.L4690L|MACF1_ENST00000317713.7_Silent_p.L4188L|MACF1_ENST00000539005.1_Silent_p.L4058L			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6256					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCACTGACCTCAATACTGTTA	0.353000													3	145					0	0	0.115264	0	0
DHX37	57647	broad.mit.edu	37	12	125432580	125432580	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr12:125432580C>T	ENST00000544745.1	-	23	2908	c.2799G>A	c.(2797-2799)ctG>ctA	p.L933L	DHX37_ENST00000308736.2_Intron			Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	0							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GCCCCTGCCTCAGTGACCCCA	0.597000													5	86					0	0	0.184627	0	0
MRPL3	11222	broad.mit.edu	37	3	131190031	131190031	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr3:131190031C>A	ENST00000264995.3	-	7	869	c.722G>T	c.(721-723)gGa>gTa	p.G241V	MRPL3_ENST00000425847.2_Missense_Mutation_p.G268V	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	241					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						TGCAACAGCTCCAGGTCTCCT	0.423000													8	148					0.00307968	0.00347359	0.278610	1	0
PVRL4	81607	broad.mit.edu	37	1	161043540	161043540	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:161043540C>T	ENST00000368012.3	-	7	1505	c.1203G>A	c.(1201-1203)ctG>ctA	p.L401L	PVRL4_ENST00000486694.1_5'UTR|PVRL4_ENST00000453926.2_Silent_p.L135L	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	401					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GATGGGAATGCAGCCTCCGGA	0.622000													5	237					0	0	0.184627	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57077492	57077492	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:57077492G>A	ENST00000532437.1	-	5	3004	c.2693C>T	c.(2692-2694)gCc>gTc	p.A898V	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.A898V|TNKS1BP1_ENST00000530920.1_5'UTR			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	898	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding	p.A898V(1)		breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				ATCTTGGCTGGCATAAGCACC	0.532000													5	437					0	0	0.217242	0	0
PIM1	5292	broad.mit.edu	37	6	37140830	37140830	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:37140830G>A	ENST00000373509.5	+	5	1039	c.666G>A	c.(664-666)tcG>tcA	p.S222S	PIM1_ENST00000468243.1_3'UTR	NM_001243186.1|NM_002648.3	NP_001230115.1|NP_002639.1	P11309	PIM1_HUMAN	pim-1 oncogene	313	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(17)|large_intestine(4)|lung(3)|prostate(2)|skin(2)	30			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	ATGGCAGGTCGGCGGCAGTCT	0.522000			T	BCL6	NHL								65	97					0	0	0.870114	0	0
DOCK5	80005	broad.mit.edu	37	8	25156591	25156591	+	Nonsense_Mutation	SNP	C	C	A	rs115024120	byFrequency	TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:25156591C>A	ENST00000276440.7	+	8	782	c.738C>A	c.(736-738)taC>taA	p.Y246*	DOCK5_ENST00000481100.1_Nonsense_Mutation_p.Y246*	NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	246						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TGGCCCTCTACGACCCAGACC	0.522000													3	137					0.014758	0.0160846	0.184627	1	0
ZNRF3	84133	broad.mit.edu	37	22	29446410	29446410	+	Silent	SNP	T	T	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr22:29446410T>G	ENST00000544604.2	+	8	2416	c.2241T>G	c.(2239-2241)ggT>ggG	p.G747G	ZNRF3_ENST00000402174.1_Silent_p.G647G|ZNRF3_ENST00000406323.3_Silent_p.G647G|ZNRF3_ENST00000332811.4_Silent_p.G647G	NM_001206998.1	NP_001193927.1	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	747						integral to membrane	zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(4)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	28						GCCCGGCGGGTGGGGAGCCCC	0.692000													9	43					0	0	0.834066	0	0
ADAM2	2515	broad.mit.edu	37	8	39624556	39624556	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:39624556A>T	ENST00000265708.4	-	14	1421	c.1318T>A	c.(1318-1320)Tca>Aca	p.S440T	ADAM2_ENST00000379853.2_Missense_Mutation_p.S314T|ADAM2_ENST00000347580.4_Missense_Mutation_p.S421T|ADAM2_ENST00000521880.1_Missense_Mutation_p.S440T	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	440	Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTTTCTTTTGACATAAACTGA	0.343000													331	117					0	0	0.870114	0	0
FNDC1	84624	broad.mit.edu	37	6	159653589	159653589	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:159653589G>A	ENST00000297267.9	+	11	2245	c.2045G>A	c.(2044-2046)cGc>cAc	p.R682H	FNDC1_ENST00000340366.6_Missense_Mutation_p.R619H	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	682	Ser-rich.					extracellular region		p.R682H(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCGTTCTCCGCGACAGAAGC	0.716000													19	21					0	0	0.706142	0	0
TRAF3	7187	broad.mit.edu	37	14	103363706	103363706	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr14:103363706C>T	ENST00000560371.1	+	9	1145	c.928C>T	c.(928-930)Cga>Tga	p.R310*	TRAF3_ENST00000539721.1_Nonsense_Mutation_p.R227*|TRAF3_ENST00000392745.2_Nonsense_Mutation_p.R310*|TRAF3_ENST00000347662.4_Nonsense_Mutation_p.R285*|TRAF3_ENST00000351691.5_Nonsense_Mutation_p.R285*	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	310					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.R310*(1)		breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		GGAAATGCTTCGAAATAATGA	0.378000													27	7					0	0	0.693898	0	0
ITGAL	3683	broad.mit.edu	37	16	30522385	30522385	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:30522385C>G	ENST00000356798.6	+	24	2894	c.2714C>G	c.(2713-2715)tCa>tGa	p.S905*	ITGAL_ENST00000358164.5_Nonsense_Mutation_p.S821*|ITGAL_ENST00000433423.2_Nonsense_Mutation_p.S139*	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	905					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	AATGAGGACTCAGACCTCCTG	0.567000													53	72					0	0	0.870114	0	0
PKNOX2	63876	broad.mit.edu	37	11	125301145	125301145	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:125301145G>A	ENST00000298282.9	+	13	1547	c.1276G>A	c.(1276-1278)Gat>Aat	p.D426N	PKNOX2_ENST00000542175.1_Missense_Mutation_p.D362N|PKNOX2_ENST00000530517.1_3'UTR	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	426	Asp/Glu-rich (acidic).					nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		GGCTGCACACGATGACTCATT	0.552000													18	29					0	0	0.557998	0	0
RHOU	58480	broad.mit.edu	37	1	228879110	228879110	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:228879110T>C	ENST00000366691.3	+	3	1066	c.400T>C	c.(400-402)Tca>Cca	p.S134P		NM_021205.5	NP_067028.1	Q7L0Q8	RHOU_HUMAN	ras homolog family member U	134					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	13	Breast(184;0.162)	Prostate(94;0.183)				CGTGAGCCCCTCATCCTTCCA	0.527000													4	423					0	0	0.150653	0	0
RIPK4	54101	broad.mit.edu	37	21	43161351	43161351	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr21:43161351A>G	ENST00000352483.2	-	9	2210	c.2146T>C	c.(2146-2148)Tca>Cca	p.S716P	RIPK4_ENST00000332512.3_Missense_Mutation_p.S668P|RIPK4_ENST00000542057.1_Missense_Mutation_p.S605P|RIPK4_ENST00000544709.1_Missense_Mutation_p.S605P|AP001615.9_ENST00000423276.1_RNA			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	668						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TAGCCGTCTGAGGTCATGGCC	0.687000													82	78					0	0	0.870114	0	0
MAP3K12	7786	broad.mit.edu	37	12	53877172	53877172	+	Missense_Mutation	SNP	T	T	C	rs140537763		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr12:53877172T>C	ENST00000267079.2	-	11	1700	c.1475A>G	c.(1474-1476)aAg>aGg	p.K492R	MAP3K12_ENST00000547035.1_Missense_Mutation_p.K525R|MAP3K12_ENST00000547488.1_Missense_Mutation_p.K525R	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	492					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						CACATTCCTCTTCTTGATAAG	0.532000													127	162					0	0	0.870114	0	0
LOC643733	643733	broad.mit.edu	37	11	104776204	104776204	+	RNA	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:104776204G>A	ENST00000532510.1	-	0	3228																											AGGTGGCAGCGCCAGGAATAT	0.438000													68	14					0	0	0.870114	0	0
AP1B1	162	broad.mit.edu	37	22	29747175	29747175	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr22:29747175G>A	ENST00000357586.2	-	9	1326	c.1140C>T	c.(1138-1140)tgC>tgT	p.C380C	AP1B1_ENST00000402502.1_Silent_p.C380C|AP1B1_ENST00000317368.7_Silent_p.C380C|AP1B1_ENST00000432560.2_Silent_p.C380C|AP1B1_ENST00000405198.1_Silent_p.C380C|AP1B1_ENST00000356015.2_Silent_p.C380C|AP1B1_ENST00000415447.1_Silent_p.C380C	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	380					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						CCTTGATGGCGCAGCGGCCAA	0.547000													13	482					0	0	0.520397	0	0
STK35	140901	broad.mit.edu	37	20	2097996	2097996	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr20:2097996G>A	ENST00000381482.3	+	3	1848	c.1577G>A	c.(1576-1578)aGa>aAa	p.R526K	STK35_ENST00000400064.3_Intron|STK35_ENST00000246032.3_Missense_Mutation_p.R393K			Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	526	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			large_intestine(2)|liver(2)|lung(6)|ovary(1)|prostate(2)	13						CTTGAAACCAGAATGGACCAG	0.438000													65	10					0	0	0.870114	0	0
SOGA3	387104	broad.mit.edu	37	6	127796906	127796906	+	Silent	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:127796906G>A	ENST00000556132.1	-	6	3129	c.2265C>T	c.(2263-2265)agC>agT	p.S755S	SOGA3_ENST00000368268.2_Silent_p.S755S|SOGA3_ENST00000465909.2_Silent_p.S755S|SOGA3_ENST00000525778.1_Silent_p.S755S|SOGA3_ENST00000481848.2_Silent_p.S755S	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	755						integral to membrane											TGCCCGCGTCGCTCTCGGCGT	0.692000													94	99					0	0	0.870114	0	0
ZIM2	23619	broad.mit.edu	37	19	57286109	57286109	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:57286109G>T	ENST00000391708.3	-	12	2073	c.1531C>A	c.(1531-1533)Caa>Aaa	p.Q511K	ZIM2_ENST00000593711.1_Missense_Mutation_p.Q511K|ZIM2_ENST00000221722.5_Missense_Mutation_p.Q511K|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000601070.1_Missense_Mutation_p.Q511K|ZIM2_ENST00000599935.1_Missense_Mutation_p.Q511K	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		TGATAATGTTGAGTGAGGTAT	0.423000													64	66					4.83677e-39	5.72155e-39	0.870114	1	0
TMEM86A	144110	broad.mit.edu	37	11	18723189	18723189	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:18723189G>T	ENST00000280734.2	+	3	452	c.356G>T	c.(355-357)cGg>cTg	p.R119L	TMEM86A_ENST00000527002.1_3'UTR	NM_153347.1	NP_699178.1	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	119						integral to membrane				endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	11						CTGGCTCTTCGGACAGGTCTG	0.612000													58	73					2.56585e-57	3.15047e-57	0.870114	1	0
CSMD1	64478	broad.mit.edu	37	8	3245095	3245095	+	Silent	SNP	C	C	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:3245095C>T	ENST00000520002.1	-	19	3261	c.2706G>A	c.(2704-2706)ccG>ccA	p.P902P	CSMD1_ENST00000542608.1_Silent_p.P901P|CSMD1_ENST00000539096.1_Silent_p.P901P|CSMD1_ENST00000537824.1_Silent_p.P901P|CSMD1_ENST00000602723.1_Silent_p.P902P|CSMD1_ENST00000400186.3_Silent_p.P902P|CSMD1_ENST00000602557.1_Silent_p.P902P			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	902	Sushi 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGTGTACCCCGGGTCACAGC	0.607000													14	18					0	0	0.435327	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709588	128709588	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:128709588C>A	ENST00000392665.2	-	2	695	c.551G>T	c.(550-552)cGg>cTg	p.R184L	KCNJ1_ENST00000392664.2_Missense_Mutation_p.R203L|KCNJ1_ENST00000392666.1_Missense_Mutation_p.R184L|KCNJ1_ENST00000324036.3_Missense_Mutation_p.R184L|KCNJ1_ENST00000440599.2_Missense_Mutation_p.R184L	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	203					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity	p.R203Q(1)		breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CTTCCCTCCCCGTTTGCTGAT	0.478000													4	194					0.150653	0.160587	0.150653	1	0
ARMC3	219681	broad.mit.edu	37	10	23270411	23270411	+	Missense_Mutation	SNP	C	C	G	rs146538646		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr10:23270411C>G	ENST00000298032.5	+	9	1143	c.1059C>G	c.(1057-1059)ttC>ttG	p.F353L	ARMC3_ENST00000409049.3_Missense_Mutation_p.F353L|ARMC3_ENST00000376528.4_Missense_Mutation_p.F90L|ARMC3_ENST00000409983.3_Missense_Mutation_p.F353L	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	353							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AAGATTTTTTCAATAATCAGG	0.363000													57	62					0	0	0.870114	0	0
OSBP	5007	broad.mit.edu	37	11	59367971	59367971	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:59367971G>A	ENST00000263847.1	-	7	1788	c.1309C>T	c.(1309-1311)Ccg>Tcg	p.P437S		NM_002556.2	NP_002547.1	P22059	OSBP1_HUMAN	oxysterol binding protein	437	Sterol binding (By similarity).				lipid transport	Golgi membrane	oxysterol binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		AACCTTACCGGCATGGGGATC	0.488000													4	258					0	0	0.184627	0	0
SLC16A4	9122	broad.mit.edu	37	1	110906426	110906427	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:110906426_110906427insA	ENST00000369779.4	-	9	1674_1675	c.1425_1426insT	c.(1423-1428)tttaccfs	p.T476fs	SLC16A4_ENST00000541986.1_Frame_Shift_Ins_p.T414fs|SLC16A4_ENST00000437429.2_Frame_Shift_Ins_p.L372fs|SLC16A4_ENST00000472422.2_Frame_Shift_Ins_p.T428fs|SLC16A4_ENST00000369781.4_Frame_Shift_Ins_p.T308fs	NM_001201547.1|NM_004696.2	NP_001188476.1|NP_004687.1	O15374	MOT5_HUMAN	solute carrier family 16, member 4	476						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity	p.F475fs*12(1)		breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(2)|ovary(3)|prostate(1)|stomach(2)	16		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)	GCCAATGGTACAAAAAAAAAGG	0.391													10	179	---	---	---	---					
KPRP	448834	broad.mit.edu	37	1	152732518	152732520	+	In_Frame_Del	DEL	AAC	AAC	-			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:152732518_152732520delAAC	ENST00000368773.1	+	2	512_514	c.454_456delAAC	c.(454-456)del	p.N152del	KPRP_ENST00000606109.1_In_Frame_Del_p.N152del	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	152	Gln-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCAGTCCAGAACTATGTACCCT	0.507													96	129	---	---	---	---					
IRF2BP2	359948	broad.mit.edu	37	1	234743346	234743348	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:234743346_234743348delTTG	ENST00000366609.3	-	2	1329_1331	c.1299_1301delCAA	c.(1297-1302)gat>ga	p.DN433del	RP4-781K5.2_ENST00000436039.1_RNA|IRF2BP2_ENST00000491430.1_5'UTR|IRF2BP2_ENST00000366610.3_In_Frame_Del_p.DN417del	NM_182972.2	NP_892017.2	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	433					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			GCCCCCTGCATTGTCTGCTACTA	0.581													100	182	---	---	---	---					
LINC01515	101928913	broad.mit.edu	37	10	67367791	67367794	+	RNA	DEL	TTCT	TTCT	-			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr10:67367791_67367794delTTCT	ENST00000433152.3	+	0	594																											tctttctttcttctttctttcttt	0.397													3	5	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651228	+	In_Frame_Del	DEL	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	AGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	-	rs35089393	by1000genomes	TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:1651199_1651228delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	ENST00000399676.2	+	1	167_196	c.129_158delAGGCTGTGGGGGCTGTGGCTCCGGCTGTGC	c.(127-159)ggg>gg	p.GGCGGCGSGCA43del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	43				G -> GGCGS (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtgggggctgtggctccggctgtgcgggctgtggg	0.691													189	40	---	---	---	---					
OR6C65	403282	broad.mit.edu	37	12	55794772	55794773	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr12:55794772_55794773insT	ENST00000379665.2	+	1	559_560	c.460_461insT	c.(460-462)tttfs	p.F154fs		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						TTTTCTCATTATTTTTCCCCCC	0.436													22	402	---	---	---	---					
LOC105369922	105369922	broad.mit.edu	37	12	96221820	96221823	+	RNA	DEL	AGGA	AGGA	-			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr12:96221820_96221823delAGGA	ENST00000553194.1	-	0	154																											agagaaagagaggaaggaaggaag	0.485													2	4	---	---	---	---					
SELPLG	6404	broad.mit.edu	37	12	109017425	109017454	+	In_Frame_Del	DEL	TCCATGGCTGCTGGTGGAGTGGTCTGTGCT	TCCATGGCTGCTGGTGGAGTGGTCTGTGCT	-	rs139943851	byFrequency	TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr12:109017425_109017454delTCCATGGCTGCTGGTGGAGTGGTCTGTGCT	ENST00000388962.3	-	3	759_788	c.600_629delAGCACAGACCACTCCACCAGCAGCCATGGA	c.(598-630)gag>ga	p.EAQTTPPAAME200del	SELPLG_ENST00000550948.1_In_Frame_Del_p.EAQTTPPAAME210del|SELPLG_ENST00000228463.6_In_Frame_Del_p.EAQTTPPAAME226del	NM_003006.4	NP_002997.2	Q14242	SELPL_HUMAN	selectin P ligand	210	12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						GGTCTGTGCCTCCATGGCTGCTGGTGGAGTGGTCTGTGCTTCCATGGCTG	0.622													42	238	---	---	---	---					
CD2BP2	10421	broad.mit.edu	37	16	30365550	30365552	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:30365550_30365552delCAT	ENST00000305596.3	-	3	345_347	c.170_172delATG	c.(169-174)ggg>g	p.DG57del	CD2BP2_ENST00000569466.1_In_Frame_Del_p.DG57del	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	57					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						CTGGACCCCCCATCATCATCATC	0.532													7	963	---	---	---	---					
TMC4	147798	broad.mit.edu	37	19	54676754	54676755	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:54676754_54676755insC	ENST00000376591.4	-	1	189_190	c.58_59insG	c.(58-60)cccfs	p.P20fs	TMC4_ENST00000301187.4_Frame_Shift_Ins_p.P20fs	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	20						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTCCCGGGGGGCCAGCCACCCC	0.634													34	722	---	---	---	---					
