Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TACC2	10579	broad.mit.edu	37	10	123892231	123892231	+	Missense_Mutation	SNP	C	C	T	rs141016456		TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr10:123892231C>T	ENST00000369005.1	+	6	6021	c.5681C>T	c.(5680-5682)aCg>aTg	p.T1894M	TACC2_ENST00000358010.1_Missense_Mutation_p.T85M|TACC2_ENST00000493951.1_Intron|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000334433.3_Missense_Mutation_p.T1894M|TACC2_ENST00000513429.1_Missense_Mutation_p.T85M|TACC2_ENST00000515603.1_Missense_Mutation_p.T1894M|TACC2_ENST00000515273.1_Missense_Mutation_p.T1943M|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000453444.2_Missense_Mutation_p.T1943M	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1894						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CAGGTCTCTACGGATCTGATA	0.622000													12	46					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161580183	161580183	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:161580183G>A	ENST00000356592.3	+	10	1697	c.1237G>A	c.(1237-1239)Ggc>Agc	p.G413S	GABRG2_ENST00000361925.4_Missense_Mutation_p.G405S|GABRG2_ENST00000414552.2_Missense_Mutation_p.G453S|GABRG2_ENST00000393933.4_Missense_Mutation_p.G310S	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	405					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TGAAGAGTACGGCTATGAGTG	0.483000													21	88					0	0	1	0	0
FAM219B	57184	broad.mit.edu	37	15	75197010	75197010	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr15:75197010C>T	ENST00000357635.5	-	4	744	c.424G>A	c.(424-426)Gca>Aca	p.A142T	FAM219B_ENST00000563119.1_Missense_Mutation_p.A142T|FAM219B_ENST00000565772.1_Missense_Mutation_p.A56T|FAM219B_ENST00000563706.1_5'UTR	NM_020447.3	NP_065180.1	Q5XKK7	CO017_HUMAN	family with sequence similarity 219, member B	142							cytochrome-c oxidase activity										CTTGCCTCTGCAGATGAATAC	0.552000													24	124					0	0	1	0	0
SPTLC1	10558	broad.mit.edu	37	9	94809508	94809508	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr9:94809508G>A	ENST00000262554.2	-	11	1032	c.1027C>T	c.(1027-1029)Ccc>Tcc	p.P343S		NM_006415.2	NP_006406.1	O15269	SPTC1_HUMAN	serine palmitoyltransferase, long chain base subunit 1	343						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GCTAACAGGGGAGGTAACGAA	0.428000													7	52					0	0	1	0	0
FOXL1	2300	broad.mit.edu	37	16	86612494	86612494	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr16:86612494C>T	ENST00000320241.3	+	1	380	c.165C>T	c.(163-165)atC>atT	p.I55I		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	55					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						ACAGCTACATCGCGCTCATCG	0.672000													20	59					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50467748	50467748	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr7:50467748G>A	ENST00000331340.3	+	8	1138	c.983G>A	c.(982-984)cGc>cAc	p.R328H	IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000349824.4_Missense_Mutation_p.R185H|IKZF1_ENST00000357364.4_Missense_Mutation_p.R241H|IKZF1_ENST00000346667.4_Missense_Mutation_p.R98H|IKZF1_ENST00000343574.5_Missense_Mutation_p.R241H|IKZF1_ENST00000439701.1_Missense_Mutation_p.R286H|IKZF1_ENST00000359197.5_Missense_Mutation_p.R286H|IKZF1_ENST00000438033.1_Missense_Mutation_p.R241H	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	328					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAGTCCCTGCGCCCGCTGGTG	0.657000			"""D,T"""	BCL6	"""ALL, DLBCL"""								4	10					0	0	1	0	0
DIRC2	84925	broad.mit.edu	37	3	122545849	122545849	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr3:122545849C>T	ENST00000261038.5	+	3	1038	c.640C>T	c.(640-642)Ctt>Ttt	p.L214F		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	214					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		GACATCACCTCTTCTTGCTGC	0.433000													21	75					0	0	1	0	0
GCLC	2729	broad.mit.edu	37	6	53385631	53385631	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr6:53385631C>T	ENST00000229416.6	-	3	874	c.391G>A	c.(391-393)Gct>Act	p.A131T	GCLC_ENST00000514004.1_Missense_Mutation_p.A131T	NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	131					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	ATAGAAGTAGCCTCCTTCCGG	0.453000													37	183					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209500	140209500	+	Silent	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:140209500G>A	ENST00000529310.1	+	1	1938	c.1824G>A	c.(1822-1824)tcG>tcA	p.S608S	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1												p.S608S(2)		NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGCTTTCGTATGAGCTGC	0.657000													13	71					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33905502	33905502	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr15:33905502C>T	ENST00000389232.4	+	19	2353	c.2283C>T	c.(2281-2283)ccC>ccT	p.P761P	RYR3_ENST00000415757.3_Silent_p.P761P	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	761	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATGGGCAGCCCGTGCAGGGGA	0.537000													5	24					0	0	1	0	0
RUFY1	80230	broad.mit.edu	37	5	179036470	179036470	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:179036470G>A	ENST00000319449.4	+	18	2089	c.2077G>A	c.(2077-2079)Gac>Aac	p.D693N	RUFY1_ENST00000393438.2_Missense_Mutation_p.D585N|RUFY1_ENST00000377001.2_3'UTR|RUFY1_ENST00000508797.1_3'UTR|RUFY1_ENST00000437570.2_Missense_Mutation_p.D585N	NM_025158.4	NP_079434.3	Q96T51	RUFY1_HUMAN	RUN and FYVE domain containing 1	693					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGAGTGTGCGACAGCTGCCA	0.652000										HNSCC(44;0.11)			5	19					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247712493	247712493	+	Missense_Mutation	SNP	G	G	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr1:247712493G>T	ENST00000366490.3	+	4	520	c.362G>T	c.(361-363)aGa>aTa	p.R121I	GCSAML_ENST00000366488.4_5'UTR|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366491.2_5'UTR|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000536561.1_5'UTR|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366489.1_5'UTR					germinal center-associated, signaling and motility-like																		ACTGTGAAAAGATGGGAAATT	0.488000													6	31					8.12818e-05	8.62992e-05	1	1	0
MGAT3	4248	broad.mit.edu	37	22	39883837	39883837	+	Missense_Mutation	SNP	G	G	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr22:39883837G>T	ENST00000341184.6	+	2	700	c.485G>T	c.(484-486)cGa>cTa	p.R162L		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	162					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					ACGGGGGGCCGAGGCGCCCGG	0.766000													3	7					1	1	1	1	0
DUSP1	1843	broad.mit.edu	37	5	172195950	172195950	+	Missense_Mutation	SNP	G	G	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:172195950G>T	ENST00000239223.3	-	4	1161	c.919C>A	c.(919-921)Cag>Aag	p.Q307K	RP11-779O18.3_ENST00000523005.1_RNA	NM_004417.3	NP_004408.1	P28562	DUS1_HUMAN	dual specificity phosphatase 1	307	Tyrosine-protein phosphatase.				cell cycle|endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|breast(2)|endometrium(1)|large_intestine(1)|liver(1)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	Renal(175;0.000159)|Lung NSC(126;0.00431)|all_lung(126;0.00729)	all_hematologic(541;4.11e-18)|Breast(839;0.00637)|Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.15)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)	GBM - Glioblastoma multiforme(465;0.0103)		GACTCAAACTGCAGCAGCTGG	0.587000													14	44					4.3838e-07	4.83342e-07	1	1	0
ASB4	51666	broad.mit.edu	37	7	95125141	95125141	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr7:95125141C>T	ENST00000325885.5	+	2	330	c.259C>T	c.(259-261)Cat>Tat	p.H87Y	ASB4_ENST00000257621.4_3'UTR|ASB4_ENST00000428113.1_Missense_Mutation_p.H87Y	NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	87					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CTTGTTTGGCCATGTGGAATG	0.443000													12	61					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6620306	6620306	+	Silent	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr9:6620306G>A	ENST00000321612.6	-	3	498	c.348C>T	c.(346-348)atC>atT	p.I116I		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	116					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GAGTTGCAAGGATTTCATTTT	0.388000													17	54					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	G	A	rs121913387		TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr9:21971186G>A	ENST00000304494.5	-	2	442	c.172C>T	c.(172-174)Cga>Tga	p.R58*	CDKN2A_ENST00000530628.2_Missense_Mutation_p.P72L|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P72L|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P113L|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R7*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	58			R -> Q (in dbSNP:rs36204273).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R58*(78)|p.?(45)|p.M53_R58del(3)|p.P113L(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*88(2)|p.0(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.P113fs*>61(1)|p.R58fs*62(1)|p.R58fs*61(1)|p.G55fs*86(1)|p.R58R(1)|p.A57fs*85(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	7					0	0	1	0	0
PNPT1	87178	broad.mit.edu	37	2	55900087	55900087	+	Silent	SNP	G	G	C			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr2:55900087G>C	ENST00000447944.2	-	9	893	c.807C>G	c.(805-807)acC>acG	p.T269T		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	269					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTGTCCTCTTGGTAACACCAG	0.373000													20	83					0	0	1	0	0
MAPK1	5594	broad.mit.edu	37	22	22127164	22127164	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr22:22127164C>T	ENST00000215832.6	-	7	1152	c.964G>A	c.(964-966)Gag>Aag	p.E322K	MAPK1_ENST00000398822.3_Missense_Mutation_p.E322K|MAPK1_ENST00000544786.1_Missense_Mutation_p.E278K	NM_002745.4	NP_002736.3	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity	p.E322K(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478000													57	44					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135352412	135352412	+	Missense_Mutation	SNP	A	A	G			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr10:135352412A>G	ENST00000463117.2	+	11	1698	c.1426A>G	c.(1426-1428)Att>Gtt	p.I476V	SPRN_ENST00000541506.1_Intron|CYP2E1_ENST00000252945.3_Missense_Mutation_p.I476V			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	476					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CCCTATACATATTGGGTTTGG	0.473000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				15	46					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10149469	10149469	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr12:10149469C>T	ENST00000428126.2	-	5	584	c.315G>A	c.(313-315)ctG>ctA	p.L105L	CLEC1B_ENST00000298527.6_Silent_p.L138L|CLEC1B_ENST00000348658.4_Silent_p.L105L			Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	138					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						TGTCAATCTTCAGGAGAGTAG	0.398000													15	72					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55221935	55221935	+	RNA	SNP	G	G	A	rs45588833	by1000genomes	TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr19:55221935G>A	ENST00000413439.1	+	0	1462																											CGGGCCCCACGGTGGCCTCAG	0.637000													4	46					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127014574	127014574	+	Silent	SNP	T	T	C	rs146028755	byFrequency	TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr7:127014574T>C	ENST00000393313.1	-	5	1407	c.816A>G	c.(814-816)caA>caG	p.Q272Q	ZNF800_ENST00000393312.1_Silent_p.Q272Q|ZNF800_ENST00000265827.3_Silent_p.Q272Q			Q2TB10	ZN800_HUMAN	zinc finger protein 800	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						CTTTAGAGGATTGGTTTGGAT	0.373000													28	82					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413896	72413896	+	Missense_Mutation	SNP	A	A	G			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr7:72413896A>G	ENST00000395270.1	+	14	3610	c.2569A>G	c.(2569-2571)Acc>Gcc	p.T857A	POM121_ENST00000257622.4_Missense_Mutation_p.T857A|POM121_ENST00000434423.2_Missense_Mutation_p.T1122A|POM121_ENST00000358357.3_Missense_Mutation_p.T857A|POM121_ENST00000446813.1_Missense_Mutation_p.T857A	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1122	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore		p.T857A(8)		NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				AGGCTCCAGCACCACCACCGG	0.637000													4	31					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	C	T	rs121912656		TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr17:7577547C>T	ENST00000420246.2	-	7	866	c.734G>A	c.(733-735)gGc>gAc	p.G245D	TP53_ENST00000359597.4_Missense_Mutation_p.G245D|TP53_ENST00000455263.2_Missense_Mutation_p.G245D|TP53_ENST00000269305.4_Missense_Mutation_p.G245D|TP53_ENST00000413465.2_Missense_Mutation_p.G245D|TP53_ENST00000445888.2_Missense_Mutation_p.G245D	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	245	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245D(104)|p.G245V(66)|p.G245A(8)|p.0?(8)|p.?(5)|p.G152V(4)|p.G244_M246>V(3)|p.G152D(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.G245fs*2(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.M243fs*18(1)|p.C238_M246delCNSSCMGGM(1)|p.G151_M153>V(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	33					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99182508	99182508	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr2:99182508C>T	ENST00000074304.5	+	22	2704	c.2311C>T	c.(2311-2313)Cgg>Tgg	p.R771W	INPP4A_ENST00000523221.1_Missense_Mutation_p.R771W|INPP4A_ENST00000409540.3_Missense_Mutation_p.R732W|INPP4A_ENST00000409463.1_Missense_Mutation_p.R100W|INPP4A_ENST00000409016.3_Missense_Mutation_p.R732W|INPP4A_ENST00000467042.1_3'UTR|INPP4A_ENST00000545415.1_Missense_Mutation_p.R732W|INPP4A_ENST00000409851.3_Missense_Mutation_p.R766W	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	771					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						GTTTAACGTGCGGGTCCCTCT	0.657000													3	12					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120572126	120572126	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr12:120572126G>A	ENST00000300648.6	-	53	7298	c.7286C>T	c.(7285-7287)tCa>tTa	p.S2429L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2429					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCAGGAGTGAGACGATGTT	0.572000													16	47					0	0	1	0	0
C3orf56	285311	broad.mit.edu	37	3	126915914	126915914	+	Missense_Mutation	SNP	C	C	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr3:126915914C>A	ENST00000398112.1	+	2	626	c.386C>A	c.(385-387)cCt>cAt	p.P129H		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		AACCTATTTCCTTTCCCCATG	0.612000													49	203					5.13769e-22	5.89121e-22	1	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102508997	102508997	+	Missense_Mutation	SNP	G	G	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr14:102508997G>T	ENST00000360184.4	+	69	12589	c.12425G>T	c.(12424-12426)gGc>gTc	p.G4142V	RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557551.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4142	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CTCCGTGCGGGCCGCATCTTT	0.587000													8	34					0.000157383	0.000165061	1	1	0
PCDHA11	56138	broad.mit.edu	37	5	140250305	140250305	+	Silent	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:140250305G>A	ENST00000398640.2	+	1	1617	c.1617G>A	c.(1615-1617)gcG>gcA	p.A539A	PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGATGCGGGCGTGCCGC	0.682000													20	119					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34150165	34150165	+	Missense_Mutation	SNP	T	T	G			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chrX:34150165T>G	ENST00000346193.3	-	1	282	c.231A>C	c.(229-231)ttA>ttC	p.L77F		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	77										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TTTTGGGGAGTAAAAACTCGT	0.537000													31	102					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197183646	197183646	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr2:197183646C>T	ENST00000260983.2	-	9	2150	c.1968G>A	c.(1966-1968)gtG>gtA	p.V656V	HECW2_ENST00000409111.1_Silent_p.V300V	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	656					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						ACCGTGTGTCCACAGAGGACA	0.592000													5	35					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													4	20					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128680494	128680494	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr11:128680494C>T	ENST00000344954.6	+	9	1259	c.871C>T	c.(871-873)Cgg>Tgg	p.R291W	FLI1_ENST00000534087.1_Missense_Mutation_p.R291W|FLI1_ENST00000281428.8_Missense_Mutation_p.R258W|FLI1_ENST00000429175.2_Missense_Mutation_p.R324W|FLI1_ENST00000525560.1_Missense_Mutation_p.R131W			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	324					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		CTGGGGCGAGCGGAAAAGCAA	0.552000			T	EWSR1	Ewing sarcoma								9	14					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57025928	57025928	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr8:57025928G>A	ENST00000311923.1	-	1	613	c.614C>T	c.(613-615)gCg>gTg	p.A205V		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	205	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			CAAGATGTTCGCGGGCTTCAG	0.483000													17	32					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8615225	8615225	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr19:8615225G>A	ENST00000338257.8	-	10	1187	c.920C>T	c.(919-921)gCc>gTc	p.A307V		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	307	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CAGCAGGTAGGCGGGAAAGGC	0.607000													5	15					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761533	55761533	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr11:55761533G>A	ENST00000278409.1	-	1	568	c.569C>T	c.(568-570)tCt>tTt	p.S190F		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					GATTGTGTCAGAACAAGAGAG	0.453000													14	59					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8976759	8976759	+	Nonsense_Mutation	SNP	C	C	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr19:8976759C>A	ENST00000397910.4	-	73	42510	c.42307G>T	c.(42307-42309)Gag>Tag	p.E14103*	MUC16_ENST00000596956.1_5'UTR|MUC16_ENST00000380951.5_Nonsense_Mutation_p.E744*	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14134	SEA 14.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGACCCCCTCGGTGGAGTTG	0.557000													15	23					1.49906e-05	1.61149e-05	1	1	0
OR4D11	219986	broad.mit.edu	37	11	59271436	59271436	+	Missense_Mutation	SNP	C	C	G			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr11:59271436C>G	ENST00000313253.1	+	1	388	c.388C>G	c.(388-390)Ctg>Gtg	p.L130V		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						CTCCAAGCCCCTGCACTATGT	0.522000													33	156					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126710286	126710286	+	Silent	SNP	A	A	G			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr3:126710286A>G	ENST00000251772.4	+	2	1254	c.1185A>G	c.(1183-1185)acA>acG	p.T395T	PLXNA1_ENST00000393409.2_Silent_p.T418T			Q9UIW2	PLXA1_HUMAN	plexin A1	418	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		TGGGGGGCACAGTCACCATTG	0.652000													3	33					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	3988831	3988831	+	Silent	SNP	C	C	G			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr11:3988831C>G	ENST00000300737.4	+	2	758	c.189C>G	c.(187-189)ctC>ctG	p.L63L	STIM1_ENST00000527651.1_Silent_p.L63L	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	63	EF-hand.				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		ATGAGAAACTCAGCTTCGAGG	0.488000													20	68					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378031	55378031	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr19:55378031G>A	ENST00000326321.3	+	9	1246	c.1213G>A	c.(1213-1215)Gtt>Att	p.V405I	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.V405I|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.V388I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	405					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		GGATCACTGCGTTTTCATACA	0.512000													76	246					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61512619	61512619	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr20:61512619C>T	ENST00000266070.4	-	16	5014	c.4689G>A	c.(4687-4689)gcG>gcA	p.A1563A	DIDO1_ENST00000395343.1_Silent_p.A1563A	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1563					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CCAGGCGCCTCGCCTGCCGGG	0.692000													7	46					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44152173	44152173	+	Missense_Mutation	SNP	G	G	A	rs138705367	byFrequency	TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr7:44152173G>A	ENST00000223357.3	+	18	2539	c.2234G>A	c.(2233-2235)cGg>cAg	p.R745Q	AEBP1_ENST00000450684.2_Missense_Mutation_p.R320Q	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	745	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						ACGGAGGTCCGGGCCATCATT	0.622000													10	29					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42839480	42839480	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr19:42839480C>T	ENST00000334370.4	+	5	1406	c.771C>T	c.(769-771)ctC>ctT	p.L257L	MEGF8_ENST00000251268.6_Silent_p.L257L	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	257						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TGGGTGACCTCGTCCTATACA	0.612000													8	56					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76751728	76751728	+	Silent	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr6:76751728G>A	ENST00000369950.3	-	2	372	c.183C>T	c.(181-183)ttC>ttT	p.F61F	IMPG1_ENST00000369963.3_Intron	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	61					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity	p.F61F(1)|p.F61L(1)		breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTGCCAAATCGAATATTCGTC	0.368000													20	74					0	0	1	0	0
RASSF2	9770	broad.mit.edu	37	20	4771164	4771164	+	Missense_Mutation	SNP	G	G	A	rs149919336	by1000genomes	TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr20:4771164G>A	ENST00000379400.3	-	7	665	c.470C>T	c.(469-471)aCg>aTg	p.T157M	RASSF2_ENST00000379376.2_Missense_Mutation_p.T157M|RASSF2_ENST00000478553.1_5'UTR	NM_014737.2	NP_055552.1	P50749	RASF2_HUMAN	Ras association (RalGDS/AF-6) domain family member 2	157					cell cycle|signal transduction	nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|pancreas(2)|prostate(2)|skin(2)	34						GTCACTAGGCGTCCTCACATT	0.617000													5	28					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390857	197390857	+	Missense_Mutation	SNP	G	G	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr1:197390857G>T	ENST00000367397.1	+	2	900	c.42G>T	c.(40-42)atG>atT	p.M14I	CRB1_ENST00000535699.1_Missense_Mutation_p.M564I|CRB1_ENST00000543483.1_Intron|CRB1_ENST00000538660.1_Missense_Mutation_p.M633I|CRB1_ENST00000367399.2_Missense_Mutation_p.M521I|CRB1_ENST00000367400.3_Missense_Mutation_p.M633I|CRB1_ENST00000544212.1_Missense_Mutation_p.M114I			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	633					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TCTATAATATGCCATCCACAC	0.403000													21	118					1.28384e-07	1.4339e-07	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	80085218	80085218	+	Silent	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr2:80085218G>A	ENST00000466387.1	+	8	1102	c.378G>A	c.(376-378)gcG>gcA	p.A126A	CTNNA2_ENST00000402739.4_Silent_p.A126A|CTNNA2_ENST00000496558.1_Silent_p.A126A|CTNNA2_ENST00000541047.1_Silent_p.A126A|CTNNA2_ENST00000361291.4_Silent_p.A160A|CTNNA2_ENST00000540488.1_Silent_p.A126A			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	126					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TGGTACGGGCGGCAAGGGCTT	0.552000													19	69					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149360594	149360594	+	Missense_Mutation	SNP	A	A	C			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:149360594A>C	ENST00000286298.4	+	3	1706	c.1438A>C	c.(1438-1440)Aaa>Caa	p.K480Q		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	480						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTCCCTTCAAAAAAGTGTCCT	0.423000													20	60					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47354797	47354797	+	Missense_Mutation	SNP	C	C	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr11:47354797C>A	ENST00000399249.2	-	29	3332	c.3278G>T	c.(3277-3279)gGc>gTc	p.G1093V	MYBPC3_ENST00000256993.4_Missense_Mutation_p.G1092V|MYBPC3_ENST00000545968.1_Missense_Mutation_p.G1093V			Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	1092	Fibronectin type-III 3.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		CTCCGTGTTGCCGACATCCTG	0.637000													3	2					0.115264	0.118008	1	1	0
MED13L	23389	broad.mit.edu	37	12	116409989	116409989	+	Silent	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr12:116409989G>A	ENST00000281928.3	-	26	5990	c.5784C>T	c.(5782-5784)ctC>ctT	p.L1928L		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1928					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ACACATCCTTGAGCTTTTTGC	0.468000													26	42					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													5	19					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29633900	29633900	+	Missense_Mutation	SNP	A	A	G	rs60081496	by1000genomes	TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr20:29633900A>G	ENST00000278882.3	+	9	919	c.539A>G	c.(538-540)gAa>gGa	p.E180G	FRG1B_ENST00000358464.4_Missense_Mutation_p.E180G														p.E180G(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAAACAAGAGAACCAAATTGA	0.264000													4	30					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156622478	156622478	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr1:156622478G>A	ENST00000329117.4	+	8	2072	c.1736G>A	c.(1735-1737)cGa>cAa	p.R579Q	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Missense_Mutation_p.R579Q	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	579					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGTCCCTCGAGGAGAGAGC	0.642000													8	34					0	0	1	0	0
INTS10	55174	broad.mit.edu	37	8	19683950	19683950	+	Silent	SNP	G	G	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr8:19683950G>T	ENST00000397977.3	+	9	1418	c.1020G>T	c.(1018-1020)ccG>ccT	p.P340P		NM_018142.2	NP_060612.2	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	340					snRNA processing	integrator complex	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	20				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		CTAATGCCCCGAGCCAAGTTC	0.488000													33	57					5.91797e-21	6.69665e-21	1	1	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	36					0	0	1	0	0
SCML4	256380	broad.mit.edu	37	6	108068062	108068062	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr6:108068062C>T	ENST00000369022.2	-	3	353	c.144G>A	c.(142-144)gcG>gcA	p.A48A	SCML4_ENST00000369021.3_Silent_p.A77A|SCML4_ENST00000369020.3_Silent_p.A106A			Q8N228	SCML4_HUMAN	sex comb on midleg-like 4 (Drosophila)	106					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(1)	25		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		GATAGGGCCCCGCATTGGCCT	0.642000													10	60					0	0	1	0	0
MPZL3	196264	broad.mit.edu	37	11	118104191	118104191	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr11:118104191C>T	ENST00000278949.4	-	5	720	c.665G>A	c.(664-666)cGt>cAt	p.R222H	MPZL3_ENST00000527472.1_Missense_Mutation_p.R210H|MPZL3_ENST00000525386.1_Missense_Mutation_p.V41I			Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3	222					cell adhesion	integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CTCAGCGCAACGGACACAAAG	0.493000													4	45					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447504	226447504	+	Silent	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr2:226447504C>T	ENST00000272907.6	+	4	1784	c.1371C>T	c.(1369-1371)taC>taT	p.Y457Y	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	457	Pro-rich.																CTCCCCCTTACGACGCTGTGC	0.622000													8	28					0	0	1	0	0
CYP1B1	1545	broad.mit.edu	37	2	38298060	38298060	+	Missense_Mutation	SNP	C	C	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr2:38298060C>A	ENST00000260630.3	-	3	1838	c.1437G>T	c.(1435-1437)caG>caT	p.Q479H	CYP1B1_ENST00000494864.1_5'UTR|CYP1B1_ENST00000407341.1_Missense_Mutation_p.Q479H	NM_000104.3	NP_000095.2	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B, polypeptide 1	479					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	13		all_hematologic(82;0.21)			Estrone(DB00655)	AGAGAAAAAGCTGCATCTTAG	0.463000													6	53					5.9392e-07	6.46546e-07	1	1	0
ZNF761	388561	broad.mit.edu	37	19	53960318	53960318	+	RNA	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr19:53960318G>A	ENST00000454407.1	+	0	3010							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ACACTGGAGAGAAACCTTACC	0.423000													8	29					0	0	1	0	0
SDAD1	55153	broad.mit.edu	37	4	76898824	76898824	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr4:76898824C>T	ENST00000356260.5	-	4	498	c.380G>A	c.(379-381)cGt>cAt	p.R127H	SDAD1_ENST00000395711.4_Intron	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	127					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATCATGGCAACGAAAAAGTTC	0.373000													11	49					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38154807	38154807	+	Missense_Mutation	SNP	C	C	G			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr13:38154807C>G	ENST00000379747.4	-	11	1537	c.1420G>C	c.(1420-1422)Gag>Cag	p.E474Q	POSTN_ENST00000379749.4_Missense_Mutation_p.E474Q|POSTN_ENST00000541179.1_Missense_Mutation_p.E474Q|POSTN_ENST00000379743.4_Missense_Mutation_p.E474Q|POSTN_ENST00000541481.1_Missense_Mutation_p.E474Q|POSTN_ENST00000379742.4_Missense_Mutation_p.E474Q	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	474	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CTCCCTTTCTCCATGCATGAA	0.408000													30	128					0	0	1	0	0
ZDHHC11	79844	broad.mit.edu	37	5	825360	825360	+	Silent	SNP	T	T	C			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:825360T>C	ENST00000283441.8	-	8	1325	c.942A>G	c.(940-942)aaA>aaG	p.K314K	ZDHHC11_ENST00000424784.2_Silent_p.K314K|ZDHHC11_ENST00000503758.2_5'UTR	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	314						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			AGCTCTTGGCTTTGACTCTGG	0.552000													7	96					0	0	1	0	0
SIAH1	6477	broad.mit.edu	37	16	48396084	48396084	+	Missense_Mutation	SNP	C	C	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr16:48396084C>T	ENST00000380006.2	-	1	1709	c.256G>A	c.(256-258)Gct>Act	p.A86T	SIAH1_ENST00000394725.2_Missense_Mutation_p.A86T|SIAH1_ENST00000356721.3_Missense_Mutation_p.A117T			Q8IUQ4	SIAH1_HUMAN	siah E3 ubiquitin protein ligase 1	86					axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|stomach(1)	7		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				TTCTCCATAGCCAAGTTGCGA	0.463000													13	63					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115398176	115398176	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr1:115398176G>A	ENST00000369522.3	+	2	331	c.91G>A	c.(91-93)Gat>Aat	p.D31N	SYCP1_ENST00000369518.1_Missense_Mutation_p.D31N	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	31	Asp/Glu-rich (acidic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCTGGGAGGCGATTCCACTTT	0.433000													12	37					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183774688	183774688	+	Missense_Mutation	SNP	G	G	A			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr3:183774688G>A	ENST00000318351.1	+	5	449	c.415G>A	c.(415-417)Ggt>Agt	p.G139S		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	139						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GACGCCTTCCGGTCTCACTGC	0.502000													27	129					0	0	1	0	0
NCMAP	400746	broad.mit.edu	37	1	24927452	24927452	+	Frame_Shift_Del	DEL	C	C	-			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr1:24927452delC	ENST00000374392.2	+	3	170	c.104delC	c.(103-105)gcfs	p.A35fs	NCMAP_ENST00000486262.1_3'UTR	NM_001010980.4	NP_001010980.1			noncompact myelin associated protein																		ATTGTTGCTGCCGTTGTGGTG	0.547													15	78	---	---	---	---					
NRG2	9542	broad.mit.edu	37	5	139422532	139422534	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr5:139422532_139422534delGCT	ENST00000541337.1	-	1	350_352	c.121_123delAGC	c.(121-123)del	p.S41del	NRG2_ENST00000545385.1_In_Frame_Del_p.S41del|NRG2_ENST00000361474.1_In_Frame_Del_p.S41del|NRG2_ENST00000289409.4_In_Frame_Del_p.S41del|NRG2_ENST00000289422.7_In_Frame_Del_p.S41del|NRG2_ENST00000358522.3_In_Frame_Del_p.S41del|NRG2_ENST00000394770.1_In_Frame_Del_p.S41del	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	41	Poly-Ser.				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity	p.S41delS(2)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			tgccgctctcgctgctgctgctg	0.700													2	4	---	---	---	---					
STX11	8676	broad.mit.edu	37	6	144508360	144508361	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr6:144508360_144508361delGC	ENST00000367568.4	+	2	779_780	c.596_597delGC	c.(595-597)gfs	p.G199fs		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	199					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GACGTGAAGGGCGCGCGGGCCG	0.634									Familial Hemophagocytic Lymphohistiocytosis				8	46	---	---	---	---					
BCL11B	64919	broad.mit.edu	37	14	99641544	99641546	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr14:99641544_99641546delCTC	ENST00000345514.2	-	3	1680_1682	c.1414_1416delGAG	c.(1414-1416)del	p.E472del	BCL11B_ENST00000357195.3_In_Frame_Del_p.E543del|BCL11B_ENST00000443726.2_In_Frame_Del_p.E349del	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	543						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CCAGTAGCAGctcctcctcctcc	0.700			T	TLX3	T-ALL								4	9	---	---	---	---					
SERPINB11	89778	broad.mit.edu	37	18	61378551	61378552	+	RNA	INS	-	-	T			TCGA-C9-A480-01A-12D-A24D-08	TCGA-C9-A480-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b69a2eb7-d372-4bee-b621-5ed211223f92	230541f9-3ba3-4a77-9f10-0d76eff80f37	g.chr18:61378551_61378552insT	ENST00000544088.1	+	0	230				SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000489748.1_RNA|SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				CAAAAGATCCCTTTTTTTTCTT	0.337													10	47	---	---	---	---					
