Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MARS2	92935	broad.mit.edu	37	2	198570720	198570720	+	Silent	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:198570720C>G	ENST00000282276.6	+	1	634	c.591C>G	c.(589-591)ctC>ctG	p.L197L	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	197					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity	p.L197L(1)		breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	CTGTATCTCTCGAGAGCGGGC	0.587000													57	119					0	0	0.139131	0	0
SARS	6301	broad.mit.edu	37	1	109778722	109778722	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:109778722G>T	ENST00000369923.4	+	8	1104	c.1093G>T	c.(1093-1095)Gtc>Ttc	p.V365F	SARS_ENST00000234677.2_Missense_Mutation_p.V365F			P49591	SYSC_HUMAN	seryl-tRNA synthetase	365					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	17		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TGTGAATATTGTCTCAGGTAT	0.507000													63	84					1.42676e-28	1.67301e-28	0.139131	1	0
CLCA2	9635	broad.mit.edu	37	1	86919091	86919091	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:86919091G>A	ENST00000370565.4	+	13	2357	c.2195G>A	c.(2194-2196)aGa>aAa	p.R732K	CLCA2_ENST00000498802.1_3'UTR	NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	732					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TCAGTAGGCAGAAATGAGGAG	0.453000													4	108					0	0	0.021553	0	0
DNAJC2	27000	broad.mit.edu	37	7	102953456	102953456	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102953456A>G	ENST00000379263.3	-	16	1979	c.1729T>C	c.(1729-1731)Tgg>Cgg	p.W577R	PMPCB_ENST00000420236.2_Intron|DNAJC2_ENST00000249270.7_Missense_Mutation_p.W524R|PMPCB_ENST00000249269.4_3'UTR	NM_014377.1	NP_055192.1	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	577	SANT 2.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						ATTTTTTCCCATCTTTCAGGT	0.398000													177	838					0	0	0.139131	0	0
MYO18A	399687	broad.mit.edu	37	17	27493807	27493807	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:27493807G>A	ENST00000527372.1	-	2	332	c.152C>T	c.(151-153)tCc>tTc	p.S51F	MYO18A_ENST00000354329.4_Missense_Mutation_p.S51F|MYO18A_ENST00000533112.1_Missense_Mutation_p.S51F|MYO18A_ENST00000531253.1_Missense_Mutation_p.S51F	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	51					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACGCTTGGAGGAGCGGTTCAG	0.567000													11	16					0	0	0.080935	0	0
R3HDM2	22864	broad.mit.edu	37	12	57648863	57648863	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:57648863G>A	ENST00000402412.1	-	24	3056	c.2666C>T	c.(2665-2667)cCt>cTt	p.P889L	R3HDM2_ENST00000358907.2_Missense_Mutation_p.P875L|R3HDM2_ENST00000413953.2_Intron|R3HDM2_ENST00000347140.3_Missense_Mutation_p.P875L|R3HDM2_ENST00000403821.2_Missense_Mutation_p.P909L|R3HDM2_ENST00000393811.2_Missense_Mutation_p.P602L|R3HDM2_ENST00000441731.2_Missense_Mutation_p.P570L|RP11-123K3.4_ENST00000548184.1_RNA			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	875						nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						GATGCCCTCAGGGAGATCTGT	0.602000													48	91					0	0	0.139131	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748457	8748457	+	Silent	SNP	G	G	A	rs150651778		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:8748457G>A	ENST00000276282.6	-	1	2698	c.2112C>T	c.(2110-2112)ctC>ctT	p.L704L		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	704										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GCAGGTAGGAGAGGGCACTCT	0.627000													26	40					0	0	0.099896	0	0
PRRC2B	84726	broad.mit.edu	37	9	134350562	134350562	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:134350562G>A	ENST00000357304.4	+	15	3101	c.3046G>A	c.(3046-3048)Gag>Aag	p.E1016K	PRRC2B_ENST00000458550.1_Intron|PRRC2B_ENST00000405995.1_Intron|PRRC2B_ENST00000372249.1_5'UTR	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	1016							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						TTTTGGCCGCGAGGCCACCAA	0.562000													20	10					0	0	0.204396	0	0
NBPF3	84224	broad.mit.edu	37	1	21808093	21808093	+	Silent	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:21808093C>A	ENST00000318220.6	+	16	2317	c.1269C>A	c.(1267-1269)ctC>ctA	p.L423L	NBPF3_ENST00000342104.5_Silent_p.L467L|NBPF3_ENST00000454000.2_Silent_p.L409L|NBPF3_ENST00000318249.5_Silent_p.L479L			Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	479	NBPF 3.					cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTTCCAGGCTCAGCAGAGAGC	0.458000													44	106					1.02591e-13	1.1339e-13	0.117977	1	0
PSMC2	5701	broad.mit.edu	37	7	102988178	102988178	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102988178C>T	ENST00000435765.1	+	2	431	c.20C>T	c.(19-21)gCc>gTc	p.A7V	PSMC2_ENST00000292644.3_Missense_Mutation_p.A7V|PSMC2_ENST00000544811.1_5'UTR	NM_002803.3	NP_002794.1	P35998	PRS7_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 2	7					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	21						TACCTCGGTGCCGATCAGCGG	0.577000													35	268					0	0	0.086207	0	0
MAPK6	5597	broad.mit.edu	37	15	52339091	52339091	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:52339091C>G	ENST00000261845.5	+	2	1241	c.434C>G	c.(433-435)tCt>tGt	p.S145C		NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	145	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		TATATTCACTCTGCAAATGTA	0.468000													71	96					0	0	0.139131	0	0
ABCA3	21	broad.mit.edu	37	16	2376444	2376444	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:2376444C>T	ENST00000301732.5	-	4	724	c.24G>A	c.(22-24)gcG>gcA	p.A8A	ABCA3_ENST00000567910.1_Silent_p.A8A|ABCA3_ENST00000382381.3_Silent_p.A8A	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	8					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				AGAGGAGGAGCGCCAGCTGCC	0.602000													15	37					0	0	0.132662	0	0
IGLV1-36	28826	broad.mit.edu	37	22	22786533	22786533	+	RNA	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:22786533C>T	ENST00000390301.2	+	0	123																											CAGCCACCCTCGGTGTCTGAA	0.542000											OREG0026362	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	96					0	0	0.139131	0	0
KLHL6	89857	broad.mit.edu	37	3	183225976	183225976	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:183225976G>A	ENST00000341319.3	-	3	815	c.780C>T	c.(778-780)aaC>aaT	p.N260N		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	260	BACK.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTAAGCGCACGTTCTCGAGGA	0.577000													89	217					0	0	0.139131	0	0
C20orf194	25943	broad.mit.edu	37	20	3297377	3297377	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:3297377G>A	ENST00000252032.9	-	18	1599	c.1532C>T	c.(1531-1533)tCc>tTc	p.S511F	C20orf194_ENST00000453730.2_Missense_Mutation_p.S249F	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	511										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						AACCAGCCAGGAGCAGAATCT	0.527000													21	42					0	0	0.083992	0	0
CCDC85A	114800	broad.mit.edu	37	2	56419779	56419779	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:56419779G>A	ENST00000407595.2	+	2	946	c.444G>A	c.(442-444)ctG>ctA	p.L148L	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	148										breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGCAGAAGCTGAAAGACCTGG	0.572000													39	56					0	0	0.104719	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73021005	73021005	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:73021005G>A	ENST00000263674.3	+	1	1672	c.1322G>A	c.(1321-1323)gGc>gAc	p.G441D		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	441					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						GGACCTGGAGGCACCTCTAGG	0.607000													37	29					0	0	0.080422	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821254	5821254	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:5821254G>T	ENST00000381095.3	-	5	2092	c.1465C>A	c.(1465-1467)Cat>Aat	p.H489N	NLGN4X_ENST00000538097.1_Missense_Mutation_p.H489N|NLGN4X_ENST00000381093.2_Missense_Mutation_p.H509N|NLGN4X_ENST00000381092.1_Missense_Mutation_p.H489N|NLGN4X_ENST00000275857.6_Missense_Mutation_p.H489N	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	489					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TCATCACCATGGGCCGAATCT	0.572000													51	16					2.14255e-21	2.45014e-21	0.139131	1	0
AANAT	15	broad.mit.edu	37	17	74465350	74465350	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:74465350G>A	ENST00000250615.3	+	6	1401	c.394G>A	c.(394-396)Gag>Aag	p.E132K	AANAT_ENST00000392492.3_Missense_Mutation_p.E87K	NM_001166579.1	NP_001160051.1	Q16613	SNAT_HUMAN	aralkylamine N-acetyltransferase	87	Acetyl-CoA binding (By similarity).|N-acetyltransferase.				circadian rhythm|melatonin biosynthetic process	cytosol	aralkylamine N-acetyltransferase activity			lung(1)	1						CTGGTTCGAGGAGGGCTGCCT	0.627000													113	232					0	0	0.139131	0	0
STXBP5L	9515	broad.mit.edu	37	3	121100262	121100262	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:121100262A>G	ENST00000273666.6	+	23	2813	c.2542A>G	c.(2542-2544)Acc>Gcc	p.T848A	STXBP5L_ENST00000471454.1_Missense_Mutation_p.T824A|STXBP5L_ENST00000472879.1_Missense_Mutation_p.T824A|STXBP5L_ENST00000492541.1_Missense_Mutation_p.T848A|STXBP5L_ENST00000497029.1_Missense_Mutation_p.T822A	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	848					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AAATGACTCTACCATCTCTCC	0.408000													108	263					0	0	0.139131	0	0
PCNT	5116	broad.mit.edu	37	21	47851584	47851584	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:47851584G>T	ENST00000359568.5	+	38	8313	c.8206G>T	c.(8206-8208)Gag>Tag	p.E2736*	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2736					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GCTGGCTCAGGAGCGGAGCCA	0.637000													18	53					1.56452e-12	1.69674e-12	0.189662	1	0
MAST1	22983	broad.mit.edu	37	19	12976159	12976159	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:12976159C>T	ENST00000251472.4	+	15	1707	c.1668C>T	c.(1666-1668)ccC>ccT	p.P556P		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	556	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						ACATCGCGCCCGAGGTCATCC	0.657000													64	76					0	0	0.139131	0	0
CSMD3	114788	broad.mit.edu	37	8	113267588	113267588	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:113267588A>G	ENST00000297405.5	-	62	10175	c.9931T>C	c.(9931-9933)Tca>Cca	p.S3311P	CSMD3_ENST00000455883.2_Missense_Mutation_p.S3142P|CSMD3_ENST00000343508.3_Missense_Mutation_p.S3271P|CSMD3_ENST00000352409.3_Missense_Mutation_p.S3241P	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3311	Sushi 26.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GAAACCTCTGACTGGTATATA	0.413000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			49	88					0	0	0.139131	0	0
REST	5978	broad.mit.edu	37	4	57785989	57785989	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:57785989C>G	ENST00000309042.7	+	3	1249	c.935C>G	c.(934-936)tCa>tGa	p.S312*	REST_ENST00000514063.1_3'UTR	NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	312					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					TGTCCTTACTCAAGTTCTCAG	0.328000													40	44					0	0	0.117977	0	0
DUSP21	63904	broad.mit.edu	37	X	44703874	44703874	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:44703874G>T	ENST00000339042.4	+	1	626	c.496G>T	c.(496-498)Gtg>Ttg	p.V166L		NM_022076.3	NP_071359.3	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	166						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|skin(3)	19						TAACAACACCGTGCGCATGAT	0.507000													37	19					7.53189e-24	8.69934e-24	0.098360	1	0
ECM1	1893	broad.mit.edu	37	1	150484939	150484939	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:150484939C>T	ENST00000369047.4	+	8	1320	c.1195C>T	c.(1195-1197)Cgg>Tgg	p.R399W	ECM1_ENST00000369049.4_Missense_Mutation_p.R426W|ECM1_ENST00000346569.6_Missense_Mutation_p.R274W|ECM1_ENST00000470432.1_3'UTR	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	399	2 X approximate repeats.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTTTGCCCGTCGGGCTCCTTA	0.567000													59	173					0	0	0.139131	0	0
TBX22	50945	broad.mit.edu	37	X	79281105	79281105	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:79281105C>T	ENST00000442340.1	+	5	592	c.102C>T	c.(100-102)taC>taT	p.Y34Y	TBX22_ENST00000373294.5_Silent_p.Y154Y|TBX22_ENST00000373296.3_Silent_p.Y154Y|TBX22_ENST00000373291.1_Silent_p.Y34Y	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	154					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.Y154*(1)		breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TTTTCAGGTACGTCTATCACA	0.502000													25	23					0	0	0.125774	0	0
CNGA2	1260	broad.mit.edu	37	X	150911736	150911736	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:150911736C>T	ENST00000329903.4	+	6	794	c.761C>T	c.(760-762)gCc>gTc	p.A254V		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	254					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCACTTTGCCCGCATGTTT	0.522000													4	126					0	0	0.150653	0	0
GADD45A	1647	broad.mit.edu	37	1	68153400	68153400	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:68153400C>T	ENST00000370986.4	+	4	875	c.441C>T	c.(439-441)tgC>tgT	p.C147C	GADD45A_ENST00000370985.3_Silent_p.C113C	NM_001924.3	NP_001915.1	P24522	GA45A_HUMAN	growth arrest and DNA-damage-inducible, alpha	147					apoptosis|cell cycle arrest|cellular response to ionizing radiation|cellular response to mechanical stimulus|DNA repair|positive regulation of reactive oxygen species metabolic process|regulation of cyclin-dependent protein kinase activity|signal transduction in response to DNA damage	nucleus	protein binding			lung(2)|ovary(2)	4						TTTGTTTTTGCCGGGAAAGTC	0.358000													4	239					0	0	0.184627	0	0
ALG1L	200810	broad.mit.edu	37	3	125651539	125651539	+	Silent	SNP	A	A	C	rs147593769	by1000genomes	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:125651539A>C	ENST00000340333.3	-	3	277	c.114T>G	c.(112-114)ctT>ctG	p.L38L		NM_001015050.2|NM_001195223.1	NP_001015050.2|NP_001182152.1	Q6GMV1	ALG1L_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like	38							transferase activity, transferring glycosyl groups			large_intestine(2)|lung(2)	4						CATCAAGAGTAAGTTGTTCAA	0.423000													3	153					0	0	0.115264	0	0
CACNA1C	775	broad.mit.edu	37	12	2595407	2595407	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:2595407T>C	ENST00000399655.1	+	6	1160	c.895T>C	c.(895-897)Tac>Cac	p.Y299H	CACNA1C_ENST00000399621.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399641.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000327702.7_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399595.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399606.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399617.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399629.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399597.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000335762.5_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399649.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399634.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399591.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000480911.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000344100.3_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399638.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399637.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000347598.4_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399644.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000402845.3_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399601.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000399603.1_Missense_Mutation_p.Y299H|CACNA1C_ENST00000406454.3_Missense_Mutation_p.Y299H	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	299					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAAGACCTGCTACAACCAGGA	0.602000													16	61					0	0	0.153744	0	0
GPR75	10936	broad.mit.edu	37	2	54080671	54080671	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:54080671C>T	ENST00000394705.2	-	2	1493	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	ASB3_ENST00000498475.2_Intron|ASB3_ENST00000406625.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron	NM_006794.3	NP_006785.1	O95800	GPR75_HUMAN	G protein-coupled receptor 75	408						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCCATGGCTCGAAGTCGAGT	0.448000													94	183					0	0	0.139131	0	0
CELA3B	23436	broad.mit.edu	37	1	22313044	22313044	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:22313044C>T	ENST00000337107.6	+	7	682	c.663C>T	c.(661-663)ctC>ctT	p.L221L	CELA3B_ENST00000473526.1_3'UTR	NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	221	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						GAGGACCCCTCAACTGCCCCA	0.572000													7	96					0	0	0.047766	0	0
SLC22A4	6583	broad.mit.edu	37	5	131630460	131630460	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:131630460C>G	ENST00000200652.3	+	1	325	c.151C>G	c.(151-153)Cga>Gga	p.R51G	P4HA2_ENST00000471826.1_Intron	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	51					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GCACCGCTGTCGAGTGCCGGA	0.672000													24	47					0	0	0.099896	0	0
ZNF10	7556	broad.mit.edu	37	12	133732286	133732286	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:133732286T>G	ENST00000248211.6	+	5	676	c.454T>G	c.(454-456)Ttc>Gtc	p.F152V	ZNF268_ENST00000416488.1_Intron|ZNF10_ENST00000402932.2_Intron|ZNF10_ENST00000426665.2_Missense_Mutation_p.F152V|CTD-2140B24.4_ENST00000540096.2_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	152				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GCAAGTGGCATTCACCCAAAA	0.413000													43	64					0	0	0.124865	0	0
RIPK3	11035	broad.mit.edu	37	14	24808260	24808260	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:24808260C>T	ENST00000216274.5	-	3	650	c.432G>A	c.(430-432)aaG>aaA	p.K144K		NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	144	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		CGTTGGATGGCTTGAGGTCCC	0.627000													30	34					0	0	0.144211	0	0
SCN11A	11280	broad.mit.edu	37	3	38888755	38888755	+	Silent	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:38888755C>A	ENST00000302328.3	-	26	5004	c.4806G>T	c.(4804-4806)gtG>gtT	p.V1602V	SCN11A_ENST00000456224.3_Silent_p.V1564V|SCN11A_ENST00000450244.1_Silent_p.V1602V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1602					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTCTAAAATCACAGCAATGT	0.413000													4	148					0.00024832	0.000263128	0.150653	1	0
ATRNL1	26033	broad.mit.edu	37	10	117704253	117704253	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:117704253G>T	ENST00000355044.3	+	29	4229	c.4103G>T	c.(4102-4104)cGa>cTa	p.R1368L	ATRNL1_ENST00000423111.2_Missense_Mutation_p.R419L|ATRNL1_ENST00000303745.7_Missense_Mutation_p.R161L	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1368						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTCCGGAATCGAAAACACCTT	0.418000													69	142					1.77791e-30	2.0954e-30	0.139131	1	0
URB2	9816	broad.mit.edu	37	1	229773772	229773772	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:229773772G>T	ENST00000258243.2	+	4	3548	c.3412G>T	c.(3412-3414)Gac>Tac	p.D1138Y		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1138						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TGGAGGGGCCGACATTTCCCA	0.632000													5	152					0.014758	0.0151515	0.184627	1	0
VEPH1	79674	broad.mit.edu	37	3	156979086	156979086	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:156979086C>A	ENST00000362010.2	-	14	2646	c.2339G>T	c.(2338-2340)aGg>aTg	p.R780M	VEPH1_ENST00000392833.2_Missense_Mutation_p.R735M|VEPH1_ENST00000543418.1_Missense_Mutation_p.R735M|VEPH1_ENST00000392832.2_Missense_Mutation_p.R780M|RP11-550I24.2_ENST00000488040.1_RNA|RP11-550I24.2_ENST00000487238.1_RNA|RP11-550I24.2_ENST00000475102.1_RNA	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	780	PH.					plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			AGAGCGGTCCCTGCGTTTCTT	0.483000													4	226					0.000602214	0.000635212	0.184627	1	0
HDGFL1	154150	broad.mit.edu	37	6	22570125	22570125	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:22570125G>A	ENST00000510882.2	+	1	331	c.321G>A	c.(319-321)ccG>ccA	p.P107P	HDGFL1_ENST00000230012.3_Silent_p.P107P			Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	107										kidney(1)|large_intestine(3)|lung(7)	11	Ovarian(93;0.163)					GGCCTTGGCCGGAGCCCGAGG	0.687000													2	3					0	0	0.115264	0	0
CBFA2T3	863	broad.mit.edu	37	16	88968004	88968004	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:88968004G>A	ENST00000268679.4	-	2	608	c.212C>T	c.(211-213)aCg>aTg	p.T71M	CBFA2T3_ENST00000436887.2_Missense_Mutation_p.T71M|CBFA2T3_ENST00000360302.2_Missense_Mutation_p.T10M|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.T10M|CBFA2T3_ENST00000448839.1_Intron	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	71	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|Pro-rich.|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCGGGGCTGCGTCTTCACCTC	0.667000			T	RUNX1	AML								23	46					0	0	0.091800	0	0
CAPN10	11132	broad.mit.edu	37	2	241535795	241535795	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:241535795C>T	ENST00000391984.2	+	8	1534	c.1338C>T	c.(1336-1338)acC>acT	p.T446T	CAPN10_ENST00000404753.3_Silent_p.T446T|CAPN10_ENST00000354082.4_Intron|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000270364.7_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	446	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TGGCTGGCACCGCGTGCCATG	0.667000													4	193					0	0	0.150653	0	0
FMN1	342184	broad.mit.edu	37	15	33359987	33359987	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:33359987G>A	ENST00000334528.9	-	1	98	c.99C>T	c.(97-99)ttC>ttT	p.F33F	FMN1_ENST00000561249.1_Intron|FMN1_ENST00000559150.1_Intron|FMN1_ENST00000558197.1_Silent_p.F33F|FMN1_ENST00000559047.1_Intron	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	0	Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		ATTTCATAGAGAACTTACTCA	0.428000													42	68					0	0	0.098360	0	0
CDH10	1008	broad.mit.edu	37	5	24509693	24509693	+	Missense_Mutation	SNP	G	G	C	rs1395027		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:24509693G>C	ENST00000264463.4	-	7	1745	c.1238C>G	c.(1237-1239)tCt>tGt	p.S413C		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	413	Cadherin 4.		S -> F (in dbSNP:rs1395027).		adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S413Y(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GCTGGAAATAGAATCTGGGTC	0.483000										HNSCC(23;0.051)			43	75					0	0	0.139131	0	0
P2RY1	5028	broad.mit.edu	37	3	152554482	152554482	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554482C>T	ENST00000305097.3	+	1	1747	c.911C>T	c.(910-912)gCc>gTc	p.A304V		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	304					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			AGGGTTTATGCCACGTATCAG	0.478000													5	264					0	0	0.021553	0	0
NUDT8	254552	broad.mit.edu	37	11	67395614	67395614	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:67395614G>T	ENST00000376693.2	-	4	523	c.514C>A	c.(514-516)Ctg>Atg	p.L172M	NUDT8_ENST00000301490.4_3'UTR	NM_001243750.1	NP_001230679.1	Q8WV74	NUDT8_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 8	172	Nudix hydrolase.					mitochondrion	hydrolase activity|metal ion binding			endometrium(1)|lung(1)|prostate(1)|skin(1)	4						GGTCCATGCAGGAAGACGGGT	0.642000													28	132					1.36615e-20	1.55458e-20	0.173368	1	0
PCNT	5116	broad.mit.edu	37	21	47852115	47852115	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:47852115G>C	ENST00000359568.5	+	38	8844	c.8737G>C	c.(8737-8739)Gac>Cac	p.D2913H	PCNT_ENST00000480896.1_Intron	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2913					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTGGCAGAGAGACAAGGAGAA	0.607000													6	7					0	0	0.021553	0	0
EHMT1	79813	broad.mit.edu	37	9	140708936	140708936	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:140708936C>T	ENST00000460843.1	+	22	3261	c.3234C>T	c.(3232-3234)ctC>ctT	p.L1078L		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1078	Pre-SET.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCGGCCAGCTCAGCATGCGCT	0.642000													48	32					0	0	0.139131	0	0
FBLN5	10516	broad.mit.edu	37	14	92357640	92357640	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:92357640C>T	ENST00000267620.10	-	7	836	c.667G>A	c.(667-669)Gcg>Acg	p.A223T	FBLN5_ENST00000342058.4_Missense_Mutation_p.A182T|FBLN5_ENST00000556154.1_Missense_Mutation_p.A187T			Q9UBX5	FBLN5_HUMAN	fibulin 5	182	EGF-like 4; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				GGAACATTCGCACAGAGCTGC	0.473000													79	29					0	0	0.139131	0	0
SERPINI2	5276	broad.mit.edu	37	3	167167167	167167167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:167167167G>A	ENST00000476257.1	-	8	1286	c.988C>T	c.(988-990)Caa>Taa	p.Q330*	SERPINI2_ENST00000264677.4_Nonsense_Mutation_p.Q330*|SERPINI2_ENST00000461846.1_Nonsense_Mutation_p.Q330*|SERPINI2_ENST00000471111.1_Nonsense_Mutation_p.Q330*			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	330					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						TGCGTCACTTGGGAAACATAC	0.338000													3	89					0	0	0.184627	0	0
ZNF253	56242	broad.mit.edu	37	19	20003119	20003119	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:20003119C>T	ENST00000589717.1	+	4	1155	c.1063C>T	c.(1063-1065)Ctt>Ttt	p.L355F	ZNF253_ENST00000355650.4_Missense_Mutation_p.L279F	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	355				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATCCTCACACCTTACTACACA	0.388000													41	45					0	0	0.098360	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752699	62752699	+	RNA	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:62752699G>T	ENST00000331425.6	-	0	736					NR_003952.1																						TGTCTAGTAAGGTTTGCGGAC	0.423000													31	143					3.73148e-12	4.0279e-12	0.125774	1	0
NAPEPLD	222236	broad.mit.edu	37	7	102743965	102743965	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102743965G>C	ENST00000417955.1	-	5	1247	c.1093C>G	c.(1093-1095)Cta>Gta	p.L365V	NAPEPLD_ENST00000465647.1_Missense_Mutation_p.L365V|NAPEPLD_ENST00000341533.4_Missense_Mutation_p.L365V|NAPEPLD_ENST00000455523.2_Missense_Mutation_p.L438V|NAPEPLD_ENST00000427257.1_Missense_Mutation_p.L365V			Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	365					phospholipid catabolic process	membrane	metal ion binding			endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						TATCTCTCTAGAGCTTCATTC	0.333000													51	185					0	0	0.139131	0	0
HEPN1	641654	broad.mit.edu	37	11	124789685	124789685	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:124789685T>A	ENST00000408930.5	+	1	540	c.39T>A	c.(37-39)gaT>gaA	p.D13E	HEPACAM_ENST00000298251.4_3'UTR	NM_001037558.2	NP_001032647.2	Q6WQI6	HEPN1_HUMAN	hepatocellular carcinoma, down-regulated 1	13						cytoplasm				large_intestine(1)|lung(1)|stomach(1)	3	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		CATGGGTTGATGGCGAATCAG	0.517000													39	37					0	0	0.098360	0	0
DSTYK	25778	broad.mit.edu	37	1	205116742	205116742	+	Silent	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:205116742G>T	ENST00000367162.3	-	13	2764	c.2734C>A	c.(2734-2736)Cgg>Agg	p.R912R	DSTYK_ENST00000367161.3_Silent_p.R867R|DSTYK_ENST00000367160.4_Silent_p.R571R	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	912						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						TTGCAGAGCCGATTCATGATG	0.507000													5	402					0.014758	0.0151515	0.184627	1	0
ZNF436	80818	broad.mit.edu	37	1	23688795	23688795	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:23688795C>A	ENST00000314011.4	-	4	1216	c.1080G>T	c.(1078-1080)aaG>aaT	p.K360N	ZNF436_ENST00000374608.3_Missense_Mutation_p.K360N|ZNF436_ENST00000374609.1_Intron	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		ATTCATATGGCTTCTCTCCAG	0.483000													121	155					1.77382e-44	2.1453e-44	0.139131	1	0
OR10K1	391109	broad.mit.edu	37	1	158436255	158436255	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:158436255C>G	ENST00000289451.2	+	1	984	c.904C>G	c.(904-906)Cga>Gga	p.R302G		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					ATCAGCCCTACGAAGAACAAT	0.373000													46	135					0	0	0.124865	0	0
TP53	7157	broad.mit.edu	37	17	7577570	7577570	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:7577570C>T	ENST00000420246.2	-	7	843	c.711G>A	c.(709-711)atG>atA	p.M237I	TP53_ENST00000413465.2_Missense_Mutation_p.M237I|TP53_ENST00000269305.4_Missense_Mutation_p.M237I|TP53_ENST00000445888.2_Missense_Mutation_p.M237I|TP53_ENST00000455263.2_Missense_Mutation_p.M237I|TP53_ENST00000359597.4_Missense_Mutation_p.M237I	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	237	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> L (in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(109)|p.0?(8)|p.?(5)|p.M144I(4)|p.M237_N239delMCN(4)|p.Y236_M237delYM(1)|p.H233fs*6(1)|p.M144_N146delMCN(1)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.H233_C242del10(1)|p.M237fs*1(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGTTACACATGTAGTTGT	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	21					0	0	0.204396	0	0
ACTR5	79913	broad.mit.edu	37	20	37400305	37400305	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:37400305A>T	ENST00000243903.4	+	9	1707	c.1670A>T	c.(1669-1671)tAt>tTt	p.Y557F		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	557					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				AGGAAAGAGTATGAAGAAAAG	0.547000													59	84					0	0	0.139131	0	0
MYSM1	114803	broad.mit.edu	37	1	59147716	59147716	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:59147716C>T	ENST00000472487.1	-	8	1039	c.1000G>A	c.(1000-1002)Gat>Aat	p.D334N	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	334					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					TGCCTGGCATCAACTATTATT	0.348000													79	174					0	0	0.139131	0	0
ZNF436	80818	broad.mit.edu	37	1	23688794	23688794	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:23688794G>A	ENST00000314011.4	-	4	1217	c.1081C>T	c.(1081-1083)Cca>Tca	p.P361S	ZNF436_ENST00000374608.3_Missense_Mutation_p.P361S|ZNF436_ENST00000374609.1_Intron	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CATTCATATGGCTTCTCTCCA	0.478000													121	154					0	0	0.139131	0	0
AGAP4	119016	broad.mit.edu	37	10	46322371	46322371	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:46322371G>A	ENST00000448048.2	-	7	1109	c.984C>T	c.(982-984)gcC>gcT	p.A328A		NM_133446.2	NP_597703.2	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	328	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)|lung(1)|ovary(1)	3						TGGGTGTGCAGGCCGATGTGG	0.488000													72	216					0	0	0.139131	0	0
HYDIN	54768	broad.mit.edu	37	16	70913521	70913521	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:70913521C>G	ENST00000393567.2	-	61	10504	c.10354G>C	c.(10354-10356)Gat>Cat	p.D3452H		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3452										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GGCAAGCCATCCAAGGTAGCC	0.577000													18	83					0	0	0.069288	0	0
ADCY2	108	broad.mit.edu	37	5	7802384	7802384	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:7802384G>A	ENST00000338316.4	+	21	2771	c.2682G>A	c.(2680-2682)ccG>ccA	p.P894P	ADCY2_ENST00000537121.1_Silent_p.P714P	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	894					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.P894P(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CCTCCATTCCGGATTTCAAAG	0.473000													32	53					0	0	0.163468	0	0
NUDT8	254552	broad.mit.edu	37	11	67395615	67395615	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:67395615G>A	ENST00000376693.2	-	4	522	c.513C>T	c.(511-513)ttC>ttT	p.F171F	NUDT8_ENST00000301490.4_3'UTR	NM_001243750.1	NP_001230679.1	Q8WV74	NUDT8_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 8	171	Nudix hydrolase.					mitochondrion	hydrolase activity|metal ion binding			endometrium(1)|lung(1)|prostate(1)|skin(1)	4						GTCCATGCAGGAAGACGGGTA	0.642000													28	131					0	0	0.153744	0	0
SCD	6319	broad.mit.edu	37	10	102114253	102114253	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:102114253C>A	ENST00000370355.2	+	4	892	c.511C>A	c.(511-513)Cat>Aat	p.H171N		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	171					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TGCTGATCCTCATAATTCCCG	0.502000													69	163					3.31162e-33	3.92299e-33	0.139131	1	0
RAB5A	5868	broad.mit.edu	37	3	20025262	20025262	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:20025262G>A	ENST00000273047.4	+	6	1131	c.595G>A	c.(595-597)Gta>Ata	p.V199I	RAB5A_ENST00000422242.1_Missense_Mutation_p.V185I	NM_004162.4	NP_004153.2	P20339	RAB5A_HUMAN	RAB5A, member RAS oncogene family	199					blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity			lung(1)|urinary_tract(1)	2						AGGAAGAGGAGTAGACCTTAC	0.368000													9	16					0	0	0.080935	0	0
PDE4D	5144	broad.mit.edu	37	5	59284492	59284492	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:59284492C>T	ENST00000502484.2	-	3	318	c.95G>A	c.(94-96)gGa>gAa	p.G32E	PDE4D_ENST00000546160.1_Missense_Mutation_p.G32E	NM_001165899.1	NP_001159371.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	0					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GGGTTCCATTCCGCGGAAAGG	0.428000													56	126					0	0	0.139131	0	0
BOD1L1	259282	broad.mit.edu	37	4	13602595	13602595	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:13602595C>G	ENST00000040738.5	-	10	6064	c.5929G>C	c.(5929-5931)Ggt>Cgt	p.G1977R		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1977							DNA binding										GTCATAGGACCCTCACAACCT	0.483000													44	51					0	0	0.139131	0	0
RELB	5971	broad.mit.edu	37	19	45528913	45528913	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:45528913C>T	ENST00000221452.8	+	7	954	c.804C>T	c.(802-804)atC>atT	p.I268I	RELB_ENST00000505236.1_Silent_p.I265I|RELB_ENST00000540120.1_Silent_p.I268I	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	268	RHD.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TGGTGAGGATCTGCTTCCAGG	0.567000													93	141					0	0	0.139131	0	0
SYCP1	6847	broad.mit.edu	37	1	115489931	115489931	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:115489931G>A	ENST00000369522.3	+	27	2552	c.2312G>A	c.(2311-2313)aGa>aAa	p.R771K	SYCP1_ENST00000369518.1_Missense_Mutation_p.R771K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	771					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding	p.R771I(1)	RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAATAGAAAGAGAAGAGAAG	0.299000													43	116					0	0	0.139131	0	0
SCARA5	286133	broad.mit.edu	37	8	27737157	27737157	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:27737157C>T	ENST00000354914.3	-	8	1765	c.1280G>A	c.(1279-1281)gGa>gAa	p.G427E	SCARA5_ENST00000380385.2_Missense_Mutation_p.G202E	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)	427	SRCR.				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CACCACGTCTCCGTCCTTCTT	0.637000													74	151					0	0	0.139131	0	0
CERKL	375298	broad.mit.edu	37	2	182468677	182468677	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:182468677A>T	ENST00000410087.3	-	2	468	c.368T>A	c.(367-369)tTc>tAc	p.F123Y	CERKL_ENST00000339098.5_Missense_Mutation_p.F123Y|CERKL_ENST00000374969.2_Missense_Mutation_p.F123Y|CERKL_ENST00000374970.2_Missense_Mutation_p.F123Y|CERKL_ENST00000409440.3_Missense_Mutation_p.F123Y|CERKL_ENST00000479558.1_5'UTR	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	123					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CAAGCAGATGAAGAGTGTGAT	0.333000													11	60					0	0	0.080935	0	0
DNMBP	23268	broad.mit.edu	37	10	101639776	101639776	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:101639776C>A	ENST00000342239.3	-	16	4503	c.4412G>T	c.(4411-4413)gGg>gTg	p.G1471V	DNMBP_ENST00000540316.1_Missense_Mutation_p.G383V|DNMBP_ENST00000543621.1_Missense_Mutation_p.G693V|DNMBP_ENST00000324109.4_Missense_Mutation_p.G1447V			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1447					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TGCAGAGTCCCCTGACCTTGG	0.532000													4	143					0.150653	0.153308	0.150653	1	0
SYNGR2	9144	broad.mit.edu	37	17	76167595	76167595	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:76167595C>T	ENST00000589711.1	+	2	117	c.104C>T	c.(103-105)tCt>tTt	p.S35F	SYNGR2_ENST00000590201.1_Silent_p.L58L|SYNGR2_ENST00000585591.1_Silent_p.L114L|SYNGR2_ENST00000588282.1_Silent_p.L114L|SYNGR2_ENST00000225777.3_Silent_p.L114L|SYNGR2_ENST00000592456.1_3'UTR			O43760	SNG2_HUMAN	synaptogyrin 2	0	MARVEL.					integral to plasma membrane				endometrium(2)|large_intestine(1)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	7			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			CCCCAGCTCTCTGGACCTTCC	0.637000													34	71					0	0	0.092188	0	0
SV2C	22987	broad.mit.edu	37	5	75621244	75621244	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:75621244A>C	ENST00000502798.2	+	13	2498	c.2056A>C	c.(2056-2058)Aac>Cac	p.N686H	SV2C_ENST00000322285.7_Intron	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	686					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CGTCCTGGGAAACTTAATATT	0.522000													82	138					0	0	0.139131	0	0
TRIB3	57761	broad.mit.edu	37	20	377164	377164	+	Silent	SNP	C	C	A	rs139447354		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:377164C>A	ENST00000217233.3	+	4	1460	c.907C>A	c.(907-909)Cgg>Agg	p.R303R	TRIB3_ENST00000422053.2_Silent_p.R330R	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	303	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GCCAGCTGAACGGCTCACAGC	0.687000													69	120					5.26073e-25	6.10667e-25	0.139131	1	0
ACTR2	10097	broad.mit.edu	37	2	65473816	65473816	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:65473816A>T	ENST00000260641.5	+	3	475	c.318A>T	c.(316-318)aaA>aaT	p.K106N	ACTR2_ENST00000542850.1_Missense_Mutation_p.K51N|ACTR2_ENST00000476840.1_3'UTR|ACTR2_ENST00000377982.4_Missense_Mutation_p.K111N	NM_005722.3	NP_005713.1	P61160	ARP2_HUMAN	ARP2 actin-related protein 2 homolog (yeast)	106					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	12						GAAATTGTAAAATCTTACTCA	0.368000													72	154					0	0	0.139131	0	0
CLEC4E	26253	broad.mit.edu	37	12	8689784	8689784	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:8689784G>A	ENST00000299663.3	-	4	464	c.299C>T	c.(298-300)tCc>tTc	p.S100F	CLEC4E_ENST00000545274.1_Intron|CLEC4E_ENST00000446457.2_Intron	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	100	C-type lectin.					integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					TAACGCCCAGGAAATGGTGTC	0.463000													47	77					0	0	0.139131	0	0
EXOC6B	23233	broad.mit.edu	37	2	72945308	72945308	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:72945308G>A	ENST00000272427.6	-	6	723	c.593C>T	c.(592-594)tCt>tTt	p.S198F	EXOC6B_ENST00000410104.1_Missense_Mutation_p.S198F	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	198					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						ATCGGACATAGAAACATCTTT	0.438000													56	104					0	0	0.139131	0	0
BRSK1	84446	broad.mit.edu	37	19	55805389	55805389	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:55805389A>G	ENST00000309383.1	+	5	740	c.463A>G	c.(463-465)Aga>Gga	p.R155G	BRSK1_ENST00000590333.1_Missense_Mutation_p.R171G|BRSK1_ENST00000585418.1_Missense_Mutation_p.R155G	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	155	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TCTCAGCCACAGAGACCTAAA	0.577000													110	229					0	0	0.139131	0	0
PPIE	10450	broad.mit.edu	37	1	40214724	40214724	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:40214724G>A	ENST00000324379.5	+	8	677	c.658G>A	c.(658-660)Gat>Aat	p.D220N	PPIE_ENST00000470213.1_Silent_p.S178S|PPIE_ENST00000372830.1_Missense_Mutation_p.D220N|PPIE_ENST00000356511.2_Missense_Mutation_p.D220N	NM_006112.3	NP_006103.1	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E (cyclophilin E)	220	PPIase cyclophilin-type.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding			kidney(3)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	9	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAAGAAGTTCGATGATGAAAA	0.552000													51	94					0	0	0.139131	0	0
TOX3	27324	broad.mit.edu	37	16	52497888	52497888	+	Silent	SNP	G	G	A	rs147213203	by1000genomes	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:52497888G>A	ENST00000219746.9	-	3	650	c.366C>T	c.(364-366)ctC>ctT	p.L122L	TOX3_ENST00000407228.3_Silent_p.L117L	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	122					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						CTTGTTCCACGAGATTTCTTG	0.433000													58	118					0	0	0.139131	0	0
ULK4	54986	broad.mit.edu	37	3	41877374	41877374	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:41877374G>C	ENST00000301831.4	-	18	2208	c.1746C>G	c.(1744-1746)atC>atG	p.I582M		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	582							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTACAAGATAGATCAGCTCCC	0.393000													4	166					0	0	0.021553	0	0
FOLR1	2348	broad.mit.edu	37	11	71906662	71906662	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:71906662C>T	ENST00000393679.1	+	4	800	c.364C>T	c.(364-366)Cag>Tag	p.Q122*	RP11-807H22.7_ENST00000378140.3_RNA|FOLR1_ENST00000393676.3_Nonsense_Mutation_p.Q122*|FOLR1_ENST00000312293.4_Nonsense_Mutation_p.Q122*|FOLR1_ENST00000393681.2_Nonsense_Mutation_p.Q122*			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	122					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						CCAGGTGGATCAGAGCTGGCG	0.542000													28	199					0	0	0.125774	0	0
DNAJC27	51277	broad.mit.edu	37	2	25186283	25186283	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:25186283G>T	ENST00000264711.2	-	3	420	c.231C>A	c.(229-231)ttC>ttA	p.F77L	DNAJC27_ENST00000468467.1_5'UTR|DNAJC27_ENST00000534855.1_Missense_Mutation_p.F6L	NM_001198559.1|NM_016544.2	NP_001185488.1|NP_057628.1	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	77					protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						CCTCATAGAAGAAGGGATGTC	0.368000													22	50					1.55795e-14	1.73858e-14	0.062417	1	0
IRX4	50805	broad.mit.edu	37	5	1879734	1879734	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:1879734G>T	ENST00000505790.1	-	5	1076	c.620C>A	c.(619-621)aCg>aAg	p.T207K	IRX4_ENST00000513692.1_Missense_Mutation_p.T207K|IRX4_ENST00000231357.2_Missense_Mutation_p.T207K|IRX4_ENST00000505938.1_5'UTR	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	207					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		CGGCGGCCACGTCATCTTGTT	0.657000													35	73					1.06647e-15	1.1959e-15	0.193644	1	0
PTGER2	5732	broad.mit.edu	37	14	52781581	52781581	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:52781581G>A	ENST00000245457.5	+	1	469	c.315G>A	c.(313-315)gaG>gaA	p.E105E	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	105						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	TGGCGCCCGAGAGCCGCGCGT	0.647000													26	63					0	0	0.091800	0	0
SEC1P	653677	broad.mit.edu	37	19	49183499	49183499	+	RNA	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:49183499C>T	ENST00000430145.2	+	0	586					NR_004401.2																						ACCAGATGGGCGAGTACGCCA	0.662000													3	23					0	0	0.115264	0	0
SLC22A4	6583	broad.mit.edu	37	5	131630361	131630361	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:131630361C>G	ENST00000200652.3	+	1	226	c.52C>G	c.(52-54)Cag>Gag	p.Q18E	P4HA2_ENST00000471826.1_Intron	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	18					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GGGGCCCTTCCAGCGCCTCAT	0.617000													26	58					0	0	0.099896	0	0
SV2A	9900	broad.mit.edu	37	1	149879361	149879361	+	Silent	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:149879361T>C	ENST00000369146.3	-	10	2059	c.1569A>G	c.(1567-1569)tcA>tcG	p.S523S	SV2A_ENST00000369145.1_Silent_p.S523S	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	523					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CAAAGGACACTGACTTGAGCC	0.488000													29	113					0	0	0.108266	0	0
OR5M10	390167	broad.mit.edu	37	11	56344940	56344940	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:56344940G>A	ENST00000526812.2	-	1	323	c.258C>T	c.(256-258)ctC>ctT	p.L86L		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						TCTGTTCTGAGAGGAAATTGT	0.438000													44	86					0	0	0.124865	0	0
OR4C16	219428	broad.mit.edu	37	11	55340373	55340373	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:55340373C>A	ENST00000314634.3	+	1	770	c.770C>A	c.(769-771)aCa>aAa	p.T257K		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TTTATGTACACATGCCTTGCA	0.398000													53	109					3.76997e-23	4.33265e-23	0.139131	1	0
TICAM1	148022	broad.mit.edu	37	19	4817884	4817884	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:4817884G>T	ENST00000248244.5	-	2	735	c.506C>A	c.(505-507)tCg>tAg	p.S169*		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	169					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGGCAAAGCCGAGGATGGTGG	0.652000													7	176					0.00198382	0.00208301	0.029380	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19651350	19651350	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:19651350C>T	ENST00000284885.3	-	23	2728	c.2695G>A	c.(2695-2697)Gaa>Aaa	p.E899K		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	899	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TGATTTTCTTCCGGTAAACAA	0.323000													32	62					0	0	0.153744	0	0
KCNA4	3739	broad.mit.edu	37	11	30032952	30032952	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:30032952T>A	ENST00000328224.6	-	2	2507	c.1274A>T	c.(1273-1275)cAg>cTg	p.Q425L		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	425						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCCCTGTTGCTGGGCCAGGTC	0.507000													57	44					0	0	0.139131	0	0
SLC26A10	65012	broad.mit.edu	37	12	58018675	58018675	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:58018675C>A	ENST00000379218.2	+	11	1672	c.1361C>A	c.(1360-1362)tCc>tAc	p.S454Y	SLC26A10_ENST00000320442.4_Silent_p.I418I|SLC26A10_ENST00000490243.1_3'UTR			Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	0	STAS.					integral to membrane	antiporter activity	p.S454C(1)|p.I418M(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					GGCTCTGCATCCTGAGCTATC	0.577000													78	165					7.68447e-34	9.15007e-34	0.139131	1	0
TNRC6B	23112	broad.mit.edu	37	22	40697290	40697290	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:40697290G>A	ENST00000454349.2	+	15	4284	c.4073G>A	c.(4072-4074)gGg>gAg	p.G1358E	TNRC6B_ENST00000402203.1_Missense_Mutation_p.G554E|TNRC6B_ENST00000335727.8_Missense_Mutation_p.G1248E|TNRC6B_ENST00000301923.9_Missense_Mutation_p.G554E	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1358					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						TTGAATGTGGGGCTCCCAGAC	0.512000													12	17					0	0	0.132662	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43592113	43592113	+	RNA	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:43592113C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							CAATCTGTCTCTCACCTGTGG	0.463000													26	335					0	0	0.153744	0	0
SYT8	90019	broad.mit.edu	37	11	1858221	1858221	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:1858221G>A	ENST00000341958.3	+	7	1127	c.825G>A	c.(823-825)caG>caA	p.Q275Q	SYT8_ENST00000381968.3_Silent_p.Q289Q|SYT8_ENST00000535046.1_3'UTR			Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	289	C2 2.					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGCTGAACCAGAGGAAGTGGA	0.627000													8	89					0	0	0.038147	0	0
ADORA3	140	broad.mit.edu	37	1	112031598	112031598	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:112031598G>A	ENST00000369716.4	-	3	639	c.506C>T	c.(505-507)aCg>aTg	p.T169M	ADORA3_ENST00000369717.4_Missense_Mutation_p.T88M	NM_020683.6	NP_065734.5	P33765	AA3R_HUMAN	adenosine A3 receptor	0					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GGCAGAAGCCGTGTCCAGCAC	0.498000													33	80					0	0	0.214465	0	0
ITSN1	6453	broad.mit.edu	37	21	35166729	35166729	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:35166729C>G	ENST00000381318.3	+	17	2197	c.1909C>G	c.(1909-1911)Cga>Gga	p.R637G	ITSN1_ENST00000399352.1_Missense_Mutation_p.R637G|ITSN1_ENST00000399349.1_Missense_Mutation_p.R637G|ITSN1_ENST00000399353.1_Missense_Mutation_p.R600G|ITSN1_ENST00000381291.4_Missense_Mutation_p.R637G|ITSN1_ENST00000379960.5_Missense_Mutation_p.R637G|ITSN1_ENST00000437442.2_Missense_Mutation_p.R637G|ITSN1_ENST00000399326.3_Missense_Mutation_p.R637G|ITSN1_ENST00000399338.4_Missense_Mutation_p.R637G|ITSN1_ENST00000399355.2_Missense_Mutation_p.R637G|ITSN1_ENST00000399367.3_Missense_Mutation_p.R637G|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000381285.4_Missense_Mutation_p.R637G	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	637	KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						AGAACAAGAACGAAAGATCAT	0.373000													48	84					0	0	0.124865	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577111	14577111	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:14577111T>C	ENST00000544627.1	+	2	606	c.286T>C	c.(286-288)Tgg>Cgg	p.W96R	ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000543189.1_Missense_Mutation_p.W88R|ATF7IP_ENST00000261168.4_Missense_Mutation_p.W88R|ATF7IP_ENST00000536444.1_Missense_Mutation_p.W88R|ATF7IP_ENST00000540793.1_Missense_Mutation_p.W88R			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	88					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TAAAGCAGAATGGAAGGAAAC	0.378000													34	67					0	0	0.163468	0	0
SLC2A5	6518	broad.mit.edu	37	1	9101976	9101976	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:9101976G>C	ENST00000377424.4	-	5	618	c.439C>G	c.(439-441)Ccc>Gcc	p.P147A	SLC2A5_ENST00000535586.1_Missense_Mutation_p.P32A|SLC2A5_ENST00000536305.1_Missense_Mutation_p.P88A|SLC2A5_ENST00000377414.3_Missense_Mutation_p.P147A	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	147					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AAGTACATGGGGACCACGTTG	0.512000													12	39					0	0	0.080935	0	0
ENPP7	339221	broad.mit.edu	37	17	77710932	77710932	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:77710932C>A	ENST00000328313.5	+	4	1340	c.1119C>A	c.(1117-1119)ttC>ttA	p.F373L		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	373					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity	p.F373L(5)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GCCCTAGCTTCAGGGCGGGCC	0.607000													4	128					0.150653	0.153308	0.150653	1	0
CD33	945	broad.mit.edu	37	19	51742808	51742808	+	Silent	SNP	T	T	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:51742808T>A	ENST00000262262.4	+	7	981	c.960T>A	c.(958-960)acT>acA	p.T320T	CD33_ENST00000600557.1_3'UTR|CD33_ENST00000421133.2_Silent_p.T193T	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	320					cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	ATGGCCCCACTGAAACCTCAA	0.522000													31	50					0	0	0.134883	0	0
FAM217A	222826	broad.mit.edu	37	6	4069240	4069240	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:4069240G>C	ENST00000274673.3	-	7	1620	c.1217C>G	c.(1216-1218)tCt>tGt	p.S406C	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	406																	ACTTAAAATAGAACTTTTGGG	0.368000													74	50					0	0	0.139131	0	0
MED12L	116931	broad.mit.edu	37	3	151148153	151148153	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:151148153C>G	ENST00000474524.1	+	42	6408	c.6370C>G	c.(6370-6372)Cag>Gag	p.Q2124E	MED12L_ENST00000273432.4_Missense_Mutation_p.Q1788E	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	2124	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCGGCAGCTCCAGAAGCAGCT	0.537000													47	150					0	0	0.139131	0	0
FAM47C	442444	broad.mit.edu	37	X	37028587	37028587	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:37028587C>T	ENST00000358047.3	+	1	2156	c.2104C>T	c.(2104-2106)Ctc>Ttc	p.L702F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	702								p.L702F(2)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGTGTCCCGTCTCCACCCAGA	0.642000													61	33					0	0	0.139131	0	0
TYR	7299	broad.mit.edu	37	11	88911535	88911535	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:88911535C>T	ENST00000263321.5	+	1	916	c.414C>T	c.(412-414)ctC>ctT	p.L138L	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	138					eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TTGCCTACCTCACTTTAGCAA	0.438000													13	136					0	0	0.119110	0	0
HNF1B	6928	broad.mit.edu	37	17	36064935	36064935	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:36064935G>C	ENST00000225893.4	-	6	1689	c.1328C>G	c.(1327-1329)gCa>gGa	p.A443G	HNF1B_ENST00000561193.1_Missense_Mutation_p.A417G|HNF1B_ENST00000427275.2_Missense_Mutation_p.A417G|HNF1B_ENST00000560016.1_Missense_Mutation_p.A443G	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	443					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TTGTGCAATTGCCATGACTCC	0.463000													56	141					0	0	0.139131	0	0
ARID5B	84159	broad.mit.edu	37	10	63851964	63851964	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:63851964G>A	ENST00000279873.7	+	10	3152	c.2742G>A	c.(2740-2742)ccG>ccA	p.P914P	ARID5B_ENST00000309334.5_Silent_p.P671P	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	914					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CCAAGAACCCGCACAAACCTA	0.572000													5	255					0	0	0.184627	0	0
CFH	3075	broad.mit.edu	37	1	196712640	196712640	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:196712640G>A	ENST00000367429.4	+	20	3432	c.3192G>A	c.(3190-3192)atG>atA	p.M1064I		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	1064	Sushi 18.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						CGAGACAGATGAGTAAATATC	0.403000													68	189					0	0	0.139131	0	0
ASPM	259266	broad.mit.edu	37	1	197112028	197112028	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:197112028C>G	ENST00000367409.4	-	3	1610	c.1354G>C	c.(1354-1356)Gaa>Caa	p.E452Q	ASPM_ENST00000294732.7_Missense_Mutation_p.E452Q	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	452					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						ACTAGTTCTTCAAAAATAGCT	0.338000													6	289					0	0	0.029380	0	0
MBOAT7	79143	broad.mit.edu	37	19	54692109	54692109	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:54692109G>C	ENST00000431666.2	-	3	715	c.76C>G	c.(76-78)Cat>Gat	p.H26D	MBOAT7_ENST00000338624.6_Missense_Mutation_p.H26D|MBOAT7_ENST00000391754.1_Silent_p.T56T|MBOAT7_ENST00000245615.1_Silent_p.T56T|MBOAT7_ENST00000474910.1_5'UTR	NM_001146083.1	NP_001139555.1	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	0					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCCCGAGGATGGTGACCAGAG	0.637000													70	108					0	0	0.139131	0	0
NETO1	81832	broad.mit.edu	37	18	70461640	70461640	+	Splice_Site	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:70461640C>G	ENST00000327305.6	-	5	1127		c.e5-1		NETO1_ENST00000299430.2_Splice_Site|NETO1_ENST00000583169.1_Splice_Site	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1						memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AAGTCAGGATCTTAAAAATTG	0.294000													82	61					0	0	0.139131	0	0
ZNF714	148206	broad.mit.edu	37	19	21300358	21300358	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:21300358C>T	ENST00000596143.1	+	5	1213	c.888C>T	c.(886-888)ttC>ttT	p.F296F	ZNF714_ENST00000291770.7_3'UTR|ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000596053.1_Intron	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						TTAACCGATTCTCATACCTTA	0.348000													3	17					0	0	0.115264	0	0
ZNF610	162963	broad.mit.edu	37	19	52856995	52856995	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:52856995G>C	ENST00000601151.1	+	4	576	c.124G>C	c.(124-126)Gac>Cac	p.D42H	ZNF610_ENST00000403906.3_Missense_Mutation_p.D42H|ZNF610_ENST00000327920.8_Missense_Mutation_p.D42H|ZNF610_ENST00000321287.8_Missense_Mutation_p.D42H	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D42Y(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GAAATCCCTGGACCCTGGACA	0.493000													70	117					0	0	0.139131	0	0
XKR4	114786	broad.mit.edu	37	8	56270330	56270330	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:56270330C>T	ENST00000327381.5	+	2	999	c.899C>T	c.(898-900)gCg>gTg	p.A300V		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	300						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TATGAGTATGCGGATGTGAGT	0.453000													5	180					0	0	0.184627	0	0
CHPF	79586	broad.mit.edu	37	2	220404983	220404983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:220404983G>A	ENST00000243776.6	-	4	1698	c.1450C>T	c.(1450-1452)Cga>Tga	p.R484*	CHPF_ENST00000535926.1_Nonsense_Mutation_p.R322*	NM_024536.5	NP_078812.2	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	484						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)	21		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGCTGCACTCGGCGAGTGAGG	0.667000													14	32					0	0	0.146539	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162030	90162030	+	RNA	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:90162030G>A	ENST00000567960.1	+	0	766				TUBB8P7_ENST00000564451.1_RNA																							AGCTGGCCGTGAACATGGTCC	0.627000													17	22					0	0	0.055883	0	0
FBF1	85302	broad.mit.edu	37	17	73915956	73915956	+	Splice_Site	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:73915956C>T	ENST00000586717.1	-	19	2163		c.e19-1		FBF1_ENST00000319129.5_Splice_Site|FBF1_ENST00000389570.4_Splice_Site			A6NLR5	A6NLR5_HUMAN	Fas (TNFRSF6) binding factor 1											large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						GATGCGGCTTCTGCCAACAGA	0.602000													37	57					0	0	0.214465	0	0
RP11-407N17.3	0	broad.mit.edu	37	14	39716525	39716525	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:39716525C>T	ENST00000553728.1	+	4	960	c.747C>T	c.(745-747)agC>agT	p.S249S	MIA2_ENST00000556784.1_Silent_p.S248S|MIA2_ENST00000280082.3_Silent_p.S249S																							TACAAGAAAGCTCATTTCGGA	0.403000													46	25					0	0	0.117977	0	0
CACHD1	57685	broad.mit.edu	37	1	65117854	65117854	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:65117854G>A	ENST00000371073.2	+	10	1401	c.1401G>A	c.(1399-1401)atG>atA	p.M467I	CACHD1_ENST00000290039.5_Missense_Mutation_p.M416I|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	467	Cache 1.				calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GTTTGATAATGACTGTGAGTA	0.403000													49	113					0	0	0.139131	0	0
KANK2	25959	broad.mit.edu	37	19	11283762	11283762	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:11283762G>A	ENST00000432929.2	-	10	2490	c.2130C>T	c.(2128-2130)taC>taT	p.Y710Y	KANK2_ENST00000586659.1_Silent_p.Y702Y|KANK2_ENST00000589359.1_Silent_p.Y710Y|KANK2_ENST00000355150.5_Silent_p.Y702Y|KANK2_ENST00000589894.1_Silent_p.Y702Y	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	702										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TAATAGGGCTGTAGCCAGCAC	0.567000													77	110					0	0	0.139131	0	0
MAP3K19	80122	broad.mit.edu	37	2	135745305	135745305	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:135745305G>A	ENST00000375845.3	-	7	1167	c.1137C>T	c.(1135-1137)aaC>aaT	p.N379N	MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000392915.1_Silent_p.N396N|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000358371.4_Silent_p.N266N|MAP3K19_ENST00000315513.3_5'UTR	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		CTTGTTCATAGTTTTTGGCTA	0.378000													56	99					0	0	0.139131	0	0
PTPRF	5792	broad.mit.edu	37	1	44069435	44069435	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:44069435G>A	ENST00000359947.4	+	16	2952	c.2612G>A	c.(2611-2613)gGc>gAc	p.G871D	PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000422171.2_Missense_Mutation_p.G219D|PTPRF_ENST00000372414.3_Missense_Mutation_p.G871D|PTPRF_ENST00000372413.3_Missense_Mutation_p.G862D|PTPRF_ENST00000438120.1_Missense_Mutation_p.G862D	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	871	Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATAGATTTCGGCAAGGATGAC	0.637000													35	85					0	0	0.203993	0	0
FBXW4	6468	broad.mit.edu	37	10	103432746	103432746	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:103432746G>A	ENST00000331272.7	-	4	1219	c.601C>T	c.(601-603)Cat>Tat	p.H201Y		NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	201					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		TCCTGTTCATGAGCCGAGTAC	0.507000													42	74					0	0	0.098360	0	0
UBAC1	10422	broad.mit.edu	37	9	138825301	138825301	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:138825301G>A	ENST00000371756.3	-	10	1380	c.1163C>T	c.(1162-1164)aCg>aTg	p.T388M		NM_016172.2	NP_057256.2	Q9BSL1	UBAC1_HUMAN	UBA domain containing 1	388	STI1.					Golgi apparatus|plasma membrane	protein binding			NS(1)|biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.1e-06)|Epithelial(140;7.79e-06)		GACAGGCCCCGTTTCTGGATC	0.562000													86	62					0	0	0.139131	0	0
ZNF208	7757	broad.mit.edu	37	19	22170088	22170088	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:22170088C>T	ENST00000397126.4	-	3	304	c.156G>A	c.(154-156)ctG>ctA	p.L52L	ZNF208_ENST00000599916.1_Silent_p.L52L|ZNF208_ENST00000597040.1_Silent_p.L20L|ZNF208_ENST00000601773.1_Silent_p.L52L	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAAAAATGATCAGGTCTGGCT	0.398000													29	69					0	0	0.116897	0	0
RERE	473	broad.mit.edu	37	1	8421855	8421855	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:8421855C>T	ENST00000337907.3	-	18	2618	c.1984G>A	c.(1984-1986)Gac>Aac	p.D662N	RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.D662N|RERE_ENST00000377464.1_Missense_Mutation_p.D394N|RERE_ENST00000476556.1_Missense_Mutation_p.D108N	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	662					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTGGTCCTGTCAGCCTCCTCC	0.552000													47	107					0	0	0.139131	0	0
FRG2DP	146481	broad.mit.edu	37	16	34712201	34712201	+	RNA	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:34712201G>A	ENST00000569028.2	-	0	1153																											TGCTGAATGGGGTCAGGGTGC	0.507000													9	17					0	0	0.058154	0	0
TCF20	6942	broad.mit.edu	37	22	42610152	42610152	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:42610152G>A	ENST00000359486.3	-	1	1296	c.1160C>T	c.(1159-1161)tCt>tTt	p.S387F	TCF20_ENST00000335626.4_Missense_Mutation_p.S387F	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CATGAGAGGAGATGGGGTAGA	0.512000													62	147					0	0	0.139131	0	0
KMT2D	8085	broad.mit.edu	37	12	49445126	49445126	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:49445126G>T	ENST00000301067.7	-	10	2339	c.2340C>A	c.(2338-2340)tgC>tgA	p.C780*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CAGGCACAGCGCATAGGCATG	0.667000													27	39					1.30293e-26	1.52009e-26	0.183431	1	0
P2RY1	5028	broad.mit.edu	37	3	152554042	152554042	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554042C>T	ENST00000305097.3	+	1	1307	c.471C>T	c.(469-471)ctC>ctT	p.L157L		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	157					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGTACCCCCTCAAGTCCCTGG	0.532000													31	138					0	0	0.144211	0	0
CD40	958	broad.mit.edu	37	20	44756820	44756820	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:44756820C>G	ENST00000372285.3	+	7	675	c.603C>G	c.(601-603)atC>atG	p.I201M	CD40_ENST00000372276.3_Missense_Mutation_p.L181V|CD40_ENST00000489304.1_3'UTR	NM_001250.4	NP_001241.1	P25942	TNR5_HUMAN	CD40 molecule, TNF receptor superfamily member 5	201					B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCCCCATCATCTTCGGGATCC	0.567000									Immune Deficiency with Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	144					0	0	0.139131	0	0
ZNF880	400713	broad.mit.edu	37	19	52887510	52887510	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:52887510A>T	ENST00000422689.2	+	4	692	c.677A>T	c.(676-678)aAc>aTc	p.N226I		NM_001145434.1	NP_001138906.1	Q6PDB4	ZN880_HUMAN	zinc finger protein 880	226					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						AACAGTTCAAACCTTGTACAA	0.388000													7	22					0	0	0.029380	0	0
ZNF747	65988	broad.mit.edu	37	16	30545603	30545603	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:30545603G>C	ENST00000252799.3	-	1	1065	c.398C>G	c.(397-399)tCt>tGt	p.S133C	ZNF747_ENST00000535210.1_Missense_Mutation_p.I86M|ZNF747_ENST00000395094.3_Missense_Mutation_p.S133C|AC002310.13_ENST00000568114.1_Missense_Mutation_p.I75M|ZNF747_ENST00000568028.1_Missense_Mutation_p.I86M|ZNF747_ENST00000569360.1_Missense_Mutation_p.I86M	NM_023931.2	NP_076420.1	Q9BV97	ZN747_HUMAN	zinc finger protein 747	133	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding			kidney(1)|lung(3)|prostate(1)	5						CCACCCAGGAGATGAGCGCCG	0.687000													9	14					0	0	0.047766	0	0
FAM83H	286077	broad.mit.edu	37	8	144812752	144812752	+	Translation_Start_Site	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:144812752T>C	ENST00000388913.3	-	2	126	c.1A>G	c.(1-3)Atg>Gtg	p.M1V		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	1					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CGACGGGCCATGTTGGGGCCA	0.657000													12	25					0	0	0.093190	0	0
MICAL3	57553	broad.mit.edu	37	22	18364059	18364059	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:18364059T>C	ENST00000429452.1	-	17	2604	c.2252A>G	c.(2251-2253)aAg>aGg	p.K751R	MICAL3_ENST00000585038.1_Missense_Mutation_p.K751R|MICAL3_ENST00000383094.3_Intron|MICAL3_ENST00000444520.1_Intron|MICAL3_ENST00000400561.2_Intron|MICAL3_ENST00000207726.7_Intron|MICAL3_ENST00000414725.2_Intron|MICAL3_ENST00000441493.2_Intron	NM_001136004.1	NP_001129476.1	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	751						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		AGAACACTCCTTTTCCCGTTG	0.537000													80	129					0	0	0.139131	0	0
PPY	5539	broad.mit.edu	37	17	42018893	42018893	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:42018893C>T	ENST00000591228.1	-	2	217	c.130G>A	c.(130-132)Gag>Aag	p.E44K	PPY_ENST00000587006.1_Missense_Mutation_p.E44K|PPY_ENST00000225992.3_Missense_Mutation_p.E44K			P01298	PAHO_HUMAN	pancreatic polypeptide	44					digestion|protein secretion	extracellular region	hormone activity			large_intestine(2)|lung(1)|skin(1)	4		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCCATCTGCTCTGGTGTGGCA	0.607000													44	107					0	0	0.131918	0	0
FBXL7	23194	broad.mit.edu	37	5	15928296	15928296	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:15928296G>A	ENST00000504595.1	+	3	906	c.425G>A	c.(424-426)cGc>cAc	p.R142H	FBXL7_ENST00000329673.7_Missense_Mutation_p.R130H|FBXL7_ENST00000510662.1_Missense_Mutation_p.R95H	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	142	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CGAGTGTGCCGCCGCTGGTAC	0.672000													9	15					0	0	0.047766	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33402927	33402927	+	Splice_Site	SNP	A	A	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:33402927A>T	ENST00000418600.2	+	6	610		c.e6-1		SYNGAP1_ENST00000496374.1_Splice_Site|SYNGAP1_ENST00000428982.2_Splice_Site|SYNGAP1_ENST00000293748.5_Splice_Site	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						CCTGCCTGCCAGGGCCCGGCT	0.498000													4	158					0	0	0.150653	0	0
LRP1B	53353	broad.mit.edu	37	2	141072662	141072662	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:141072662G>T	ENST00000389484.3	-	83	13618	c.12647C>A	c.(12646-12648)tCa>tAa	p.S4216*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4216	EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAACTTACATGAATCATCTGT	0.303000										TSP Lung(27;0.18)			27	62					3.28513e-13	3.59651e-13	0.091800	1	0
TULP2	7288	broad.mit.edu	37	19	49398650	49398650	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:49398650C>T	ENST00000221399.3	-	5	466	c.322G>A	c.(322-324)Ggc>Agc	p.G108S		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	108					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GTCGGGAGGCCGCGCTCGCCC	0.632000													80	126					0	0	0.139131	0	0
SPAG17	200162	broad.mit.edu	37	1	118567969	118567969	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:118567969C>A	ENST00000336338.5	-	27	3866	c.3801G>T	c.(3799-3801)aaG>aaT	p.K1267N		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1267						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACTCATAGTGCTTCACCCTCT	0.458000													71	151					2.72615e-36	3.2799e-36	0.139131	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	213					0	0	0.184627	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27887203	27887203	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:27887203C>G	ENST00000326019.6	+	1	866	c.584C>G	c.(583-585)tCt>tGt	p.S195C		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	195	FHA.					cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					GGGAGGCTGTCTGGCTGCGAC	0.632000													32	56					0	0	0.193644	0	0
PTPRC	5788	broad.mit.edu	37	1	198721488	198721488	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:198721488G>A	ENST00000367376.2	+	30	3483	c.3312G>A	c.(3310-3312)ctG>ctA	p.L1104L	PTPRC_ENST00000442510.2_Silent_p.L1106L|PTPRC_ENST00000352140.3_Silent_p.L1056L|PTPRC_ENST00000594404.1_Silent_p.L943L|PTPRC_ENST00000348564.6_Silent_p.L945L	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1104	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TCTTTGAACTGAGACATTCCA	0.378000													19	148					0	0	0.083992	0	0
MAST2	23139	broad.mit.edu	37	1	46500768	46500768	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:46500768G>T	ENST00000361297.2	+	29	4710	c.4427G>T	c.(4426-4428)cGg>cTg	p.R1476L	MAST2_ENST00000372009.2_Missense_Mutation_p.R1286L|MAST2_ENST00000372008.1_Intron	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1476					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GCTCCCTCACGGGCCCTAGGC	0.662000													21	40					5.26018e-13	5.73161e-13	0.062417	1	0
ZNF335	63925	broad.mit.edu	37	20	44581344	44581344	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:44581344C>T	ENST00000322927.2	-	19	2807	c.2707G>A	c.(2707-2709)Gag>Aag	p.E903K	ZNF335_ENST00000426788.1_Missense_Mutation_p.E748K	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	903					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				CCTGCGGGCTCCTCGCTGTGG	0.577000													30	77					0	0	0.139131	0	0
GRM7	2917	broad.mit.edu	37	3	7188164	7188164	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:7188164C>T	ENST00000486284.1	+	2	819	c.545C>T	c.(544-546)aCg>aTg	p.T182M	GRM7_ENST00000389336.4_Missense_Mutation_p.T182M|GRM7_ENST00000402647.2_Missense_Mutation_p.T182M|GRM7_ENST00000403881.1_Missense_Mutation_p.T182M|GRM7_ENST00000357716.4_Missense_Mutation_p.T182M	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	182					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TATGCATCAACGGCACCCGAG	0.502000													64	56					0	0	0.139131	0	0
SPIRE1	56907	broad.mit.edu	37	18	12453101	12453101	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:12453101A>G	ENST00000409402.4	-	14	2080	c.1813T>C	c.(1813-1815)Ttc>Ctc	p.F605L	SPIRE1_ENST00000453447.2_Missense_Mutation_p.F471L|SPIRE1_ENST00000383356.2_Missense_Mutation_p.F432L|SPIRE1_ENST00000309836.5_Missense_Mutation_p.F394L|SPIRE1_ENST00000464481.1_5'UTR|SPIRE1_ENST00000410092.3_Missense_Mutation_p.F591L	NM_001128626.1	NP_001122098.1	Q08AE8	SPIR1_HUMAN	spire-type actin nucleation factor 1	605						cytoskeleton|perinuclear region of cytoplasm	actin binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)	28						GACCAAGTGAAGAAGGAAAAC	0.328000													4	79					0	0	0.184627	0	0
ISX	91464	broad.mit.edu	37	22	35481475	35481475	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:35481475G>A	ENST00000308700.6	+	4	1479	c.527G>A	c.(526-528)cGc>cAc	p.R176H	ISX_ENST00000404699.2_Missense_Mutation_p.R176H	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	176						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						ACTGCTCTGCGCAGGCTGGCT	0.617000													5	261					0	0	0.047766	0	0
UNC5B	219699	broad.mit.edu	37	10	73050857	73050857	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:73050857G>A	ENST00000335350.6	+	9	1701	c.1285G>A	c.(1285-1287)Gca>Aca	p.A429T	UNC5B_ENST00000373192.4_Missense_Mutation_p.A418T	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	429					apoptosis|axon guidance|regulation of apoptosis	integral to membrane		p.A429T(2)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CTTTAAGACGGCAAGGCCCAG	0.597000													6	451					0	0	0.021553	0	0
MRPS30	10884	broad.mit.edu	37	5	44813211	44813211	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:44813211C>T	ENST00000507110.1	+	4	895	c.857C>T	c.(856-858)tCa>tTa	p.S286L		NM_016640.3	NP_057724.2	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	286					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(11)|prostate(1)	20	Lung NSC(6;8.08e-07)					TCTTCAGGCTCAAAAACTGCA	0.373000													21	128					0	0	0.204396	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	125					0	0	0.047766	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481978	140481978	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:140481978C>T	ENST00000231130.2	+	1	1745	c.1745C>T	c.(1744-1746)cCg>cTg	p.P582L		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		582	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCTGAGCCGGGCTACCTG	0.701000													63	115					0	0	0.139131	0	0
PABPC5	140886	broad.mit.edu	37	X	90690656	90690656	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:90690656C>A	ENST00000312600.3	+	2	294	c.80C>A	c.(79-81)cCa>cAa	p.P27Q	PABPC5_ENST00000373105.1_Intron	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	27	RRM 1.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						GACTTGGACCCAGATGTCACC	0.592000													21	7					0.000132079	0.0001406	0.204396	1	0
KRT33B	3884	broad.mit.edu	37	17	39522833	39522833	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:39522833G>A	ENST00000251646.3	-	3	526	c.477C>T	c.(475-477)atC>atT	p.I159I		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	159	Coil 1B.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				GCAGGCTGTTGATGTCGGACT	0.562000													40	82					0	0	0.124865	0	0
PALD1	27143	broad.mit.edu	37	10	72324152	72324152	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:72324152G>A	ENST00000263563.6	+	19	2563	c.2295G>A	c.(2293-2295)cgG>cgA	p.R765R		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AAGAAATGCGGAGGCTGCAGC	0.617000													31	131					0	0	0.183431	0	0
SMARCA2	6595	broad.mit.edu	37	9	2097460	2097460	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:2097460C>A	ENST00000382203.1	+	21	3276	c.3067C>A	c.(3067-3069)Cag>Aag	p.Q1023K	SMARCA2_ENST00000349721.2_Missense_Mutation_p.Q1023K|SMARCA2_ENST00000357248.2_Missense_Mutation_p.Q1023K|SMARCA2_ENST00000382194.1_Missense_Mutation_p.Q1023K			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1023					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATATATGTTTCAGCACATTGA	0.353000													64	50					2.10369e-13	2.31406e-13	0.139131	1	0
C20orf166-AS1	253868	broad.mit.edu	37	20	61143686	61143686	+	RNA	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:61143686C>T	ENST00000475015.1	-	0	652				C20orf166-AS1_ENST00000412495.1_RNA																							GCAGCCCCCTCCGCAGACCGG	0.677000													42	84					0	0	0.139131	0	0
P2RY1	5028	broad.mit.edu	37	3	152554038	152554038	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554038C>T	ENST00000305097.3	+	1	1303	c.467C>T	c.(466-468)cCc>cTc	p.P156L		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	156					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			GTGGTGTACCCCCTCAAGTCC	0.527000													31	135					0	0	0.144211	0	0
APLF	200558	broad.mit.edu	37	2	68765290	68765290	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:68765290C>T	ENST00000303795.4	+	7	1262	c.1091C>T	c.(1090-1092)tCa>tTa	p.S364L	APLF_ENST00000471727.1_3'UTR	NM_173545.2	NP_775816.1	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	364					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	25						GCAACTGATTCAGTTCTACAA	0.443000													64	88					0	0	0.139131	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049934	90049934	+	Silent	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:90049934G>T	ENST00000330947.2	+	5	2085	c.1725G>T	c.(1723-1725)ctG>ctT	p.L575L	LRRC8B_ENST00000358200.4_Silent_p.L575L|RP5-1007M22.2_ENST00000443562.1_RNA|LRRC8B_ENST00000439853.1_Silent_p.L575L	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	575						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GAAGCAAACTGGTTGTGTTGA	0.463000													4	94					0.00909568	0.00946442	0.150653	1	0
FBXO15	201456	broad.mit.edu	37	18	71797839	71797839	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:71797839C>T	ENST00000269500.5	-	4	494	c.159G>A	c.(157-159)tgG>tgA	p.W53*	FBXO15_ENST00000419743.2_Nonsense_Mutation_p.W129*	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	53										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		AATTAAATTTCCAATTTGATC	0.348000													4	40					0	0	0.150653	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522727	95522727	+	RNA	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:95522727C>A	ENST00000432432.2	-	0	300					NR_040113.1													p.R64L(2)									CTGCTTGTCCCGGGCGTCCAG	0.731000													3	65					0.004672	0.0048834	0.115264	1	0
THBS1	7057	broad.mit.edu	37	15	39876366	39876366	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:39876366T>C	ENST00000260356.5	+	5	1046	c.881T>C	c.(880-882)cTg>cCg	p.L294P		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	294					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GTGACCACGCTGCAGGACAGC	0.557000													19	42					0	0	0.076483	0	0
SCN4A	6329	broad.mit.edu	37	17	62034533	62034533	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:62034533C>T	ENST00000435607.1	-	13	2441	c.2365G>A	c.(2365-2367)Ggc>Agc	p.G789S	SCN4A_ENST00000578147.1_Missense_Mutation_p.G789S	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	789					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	ACAAGATTGCCGATGACCATG	0.582000													17	43					0	0	0.175082	0	0
RPL10	6134	broad.mit.edu	37	X	153628938	153628938	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:153628938G>A	ENST00000424325.2	+	6	651	c.463G>A	c.(463-465)Gcc>Acc	p.A155T	RPL10_ENST00000406022.2_Missense_Mutation_p.A104T|RPL10_ENST00000369817.2_Missense_Mutation_p.A155T	NM_001256577.1|NM_001256580.1|NM_006013.3	NP_001243506.1|NP_001243509.1|NP_006004.2	P27635	RL10_HUMAN	ribosomal protein L10	155					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome			large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGCGCAGGGCCAAGTTCAA	0.582000													4	114					0	0	0.150653	0	0
HOXC9	3225	broad.mit.edu	37	12	54396297	54396297	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:54396297G>A	ENST00000303450.4	+	2	692	c.622G>A	c.(622-624)Gag>Aag	p.E208K	HOXC9_ENST00000508190.1_Missense_Mutation_p.E208K|HOXC9_ENST00000504557.1_3'UTR	NM_006897.1	NP_008828.1	P31274	HXC9_HUMAN	homeobox C9	208					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	14						GCTGGAACTGGAGAAGGAGTT	0.557000													62	119					0	0	0.139131	0	0
LCA5L	150082	broad.mit.edu	37	21	40778524	40778524	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:40778524C>T	ENST00000358268.2	-	10	1825	c.1297G>A	c.(1297-1299)Gag>Aag	p.E433K	LCA5L_ENST00000380671.2_Missense_Mutation_p.E433K|LCA5L_ENST00000288350.3_Missense_Mutation_p.E433K|LCA5L_ENST00000495240.1_5'UTR|WRB_ENST00000541890.1_Missense_Mutation_p.S163F			O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	433										breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	24		Prostate(19;1.2e-06)				AAATGTTTCTCTTCCCCTGAT	0.333000													59	132					0	0	0.139131	0	0
PDE12	201626	broad.mit.edu	37	3	57543358	57543358	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:57543358C>G	ENST00000311180.8	+	1	1355	c.1252C>G	c.(1252-1254)Cta>Gta	p.L418V	PDE12_ENST00000487257.1_Missense_Mutation_p.L418V	NM_177966.5	NP_808881.3	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	418							hydrolase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(4)|lung(3)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		GCTGGAGAAACTAGTTTTGTA	0.468000													50	41					0	0	0.139131	0	0
RNF217	154214	broad.mit.edu	37	6	125404058	125404058	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:125404058G>A	ENST00000521654.2	+	6	1604	c.1604G>A	c.(1603-1605)cGa>cAa	p.R535Q	RNF217_ENST00000368414.2_Missense_Mutation_p.R97Q|RNF217_ENST00000275184.6_Missense_Mutation_p.R179Q|RNF217_ENST00000359704.2_3'UTR|RNF217_ENST00000560949.1_Missense_Mutation_p.R300Q			Q8TC41	RN217_HUMAN	ring finger protein 217	110					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		CAGAGAAAACGATCACGGACA	0.393000													22	38					0	0	0.076483	0	0
SNRPB	6628	broad.mit.edu	37	20	2443871	2443871	+	Silent	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:2443871C>T	ENST00000339610.6	-	6	641	c.186G>A	c.(184-186)gtG>gtA	p.V62V	SNRPB_ENST00000438552.2_Silent_p.V141V|SNRPB_ENST00000381342.2_Silent_p.V141V			P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	141					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						GTGGGGTCATCACCTAAGAGG	0.552000													8	68					0	0	0.038147	0	0
CERS2	29956	broad.mit.edu	37	1	150940906	150940906	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:150940906G>A	ENST00000271688.6	-	3	642	c.256C>T	c.(256-258)Cat>Tat	p.H86Y	CERS2_ENST00000345896.4_5'UTR|CERS2_ENST00000368954.5_Missense_Mutation_p.H86Y|CERS2_ENST00000561294.1_Missense_Mutation_p.H86Y	NM_181746.3	NP_859530.1	Q96G23	CERS2_HUMAN	ceramide synthase 2	86						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										AGGTAGAAATGTTCCAAGGTG	0.572000													42	89					0	0	0.086207	0	0
CENPE	1062	broad.mit.edu	37	4	104068527	104068527	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:104068527C>T	ENST00000265148.3	-	29	4209	c.4120G>A	c.(4120-4122)Gaa>Aaa	p.E1374K	CENPE_ENST00000380026.3_Missense_Mutation_p.E1349K	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1374					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GCCAAAGTTTCTCTAATATGT	0.323000													7	100					0	0	0.029380	0	0
KCNN2	3781	broad.mit.edu	37	5	113831873	113831873	+	Silent	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:113831873T>C	ENST00000512097.3	+	9	2752	c.1734T>C	c.(1732-1734)agT>agC	p.S578S	KCNN2_ENST00000264773.3_Silent_p.S578S|KCNN2_ENST00000503706.1_Silent_p.S230S|RP11-492A10.1_ENST00000514115.1_RNA			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	578						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CATCAGAGAGTAGCTAGAAGA	0.458000													3	192					0	0	0.115264	0	0
PABPC5	140886	broad.mit.edu	37	X	90690655	90690655	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:90690655C>A	ENST00000312600.3	+	2	293	c.79C>A	c.(79-81)Cca>Aca	p.P27T	PABPC5_ENST00000373105.1_Intron	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	27	RRM 1.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						TGACTTGGACCCAGATGTCAC	0.592000													21	7					0.000132079	0.0001406	0.204396	1	0
FAM171B	165215	broad.mit.edu	37	2	187626381	187626381	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:187626381C>T	ENST00000304698.5	+	8	1515	c.1312C>T	c.(1312-1314)Cag>Tag	p.Q438*		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	438						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						ATATAGTCCTCAGAAAAAGGA	0.348000													41	91					0	0	0.080422	0	0
UBP1	7342	broad.mit.edu	37	3	33481236	33481236	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:33481236G>A	ENST00000283629.3	-	1	634	c.105C>T	c.(103-105)taC>taT	p.Y35Y	UBP1_ENST00000447368.2_Silent_p.Y35Y|UBP1_ENST00000283628.5_Silent_p.Y35Y	NM_001128161.1|NM_014517.4	NP_001121633.1|NP_055332.3	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a)	35					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|urinary_tract(2)	23						ACCTCATGCTGTAAGCGCCGG	0.667000													33	27					0	0	0.086207	0	0
GAL3ST4	79690	broad.mit.edu	37	7	99757768	99757768	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:99757768T>C	ENST00000360039.4	-	4	1636	c.1244A>G	c.(1243-1245)gAc>gGc	p.D415G	GAL3ST4_ENST00000426974.2_Missense_Mutation_p.D353G|GAL3ST4_ENST00000413800.1_Missense_Mutation_p.D415G|GAL3ST4_ENST00000423751.1_3'UTR|GAL3ST4_ENST00000411994.1_3'UTR	NM_024637.4	NP_078913.3	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	415					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTATTTGGGGTCAGAAGCCTC	0.587000													75	343					0	0	0.139131	0	0
NIPAL3	57185	broad.mit.edu	37	1	24766687	24766687	+	Missense_Mutation	SNP	C	C	T	rs143586098		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:24766687C>T	ENST00000358028.4	+	3	468	c.119C>T	c.(118-120)gCg>gTg	p.A40V	NIPAL3_ENST00000339255.2_Missense_Mutation_p.A40V|NIPAL3_ENST00000003912.3_5'UTR|NIPAL3_ENST00000428131.1_Missense_Mutation_p.A40V|NIPAL3_ENST00000374399.4_Missense_Mutation_p.A40V			Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	40						integral to membrane				endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(1)	14						GCCCTCTTGGCGATCTTCGGG	0.537000													41	108					0	0	0.139131	0	0
PCLO	27445	broad.mit.edu	37	7	82582957	82582957	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:82582957G>A	ENST00000423517.2	-	5	7649	c.7312C>T	c.(7312-7314)Ctt>Ttt	p.L2438F	PCLO_ENST00000333891.8_Missense_Mutation_p.L2438F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2369	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTTTAGGAAGAATAGTTGGT	0.517000													13	11					0	0	0.105934	0	0
PSMC2	5701	broad.mit.edu	37	7	102988177	102988177	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102988177G>T	ENST00000435765.1	+	2	430	c.19G>T	c.(19-21)Gcc>Tcc	p.A7S	PSMC2_ENST00000292644.3_Missense_Mutation_p.A7S|PSMC2_ENST00000544811.1_5'UTR	NM_002803.3	NP_002794.1	P35998	PRS7_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 2	7					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	21						TTACCTCGGTGCCGATCAGCG	0.577000													35	270					1.04594e-18	1.18437e-18	0.086207	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184678	130184678	+	Silent	SNP	G	G	A			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:130184678G>A	ENST00000422113.2	-	2	971	c.645C>T	c.(643-645)tcC>tcT	p.S215S		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	215						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTGGTCCACGGACTTCCTCC	0.692000													40	79					0	0	0.111260	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748738	8748738	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:8748738G>C	ENST00000276282.6	-	1	2417	c.1831C>G	c.(1831-1833)Caa>Gaa	p.Q611E		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	611	Roc.									endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		AGCAGGTATTGAAAATGGGCC	0.627000													49	97					0	0	0.139131	0	0
TSPAN32	10077	broad.mit.edu	37	11	2335794	2335794	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:2335794C>T	ENST00000182290.4	+	6	673	c.536C>T	c.(535-537)gCg>gTg	p.A179V	TSPAN32_ENST00000381121.3_Missense_Mutation_p.A179V|TSPAN32_ENST00000483227.1_3'UTR|TSPAN32_ENST00000451520.2_Missense_Mutation_p.A168V	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	179					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GAGGAGGCGGCGAGAGAGGTG	0.652000													9	7					0	0	0.047766	0	0
PCNXL3	399909	broad.mit.edu	37	11	65383829	65383829	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:65383829C>T	ENST00000355703.3	+	1	586	c.47C>T	c.(46-48)tCg>tTg	p.S16L		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	16						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GTGTGGGCCTCGCTCACCGGC	0.667000													9	9					0	0	0.132662	0	0
SEC22B	9554	broad.mit.edu	37	1	145109975	145109976	+	RNA	INS	-	-	C	rs67257307		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:145109975_145109976insC	ENST00000453618.1	+	0	673							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CAGGAACTTTGCTAAAGATCTA	0.386													3	4	---	---	---	---					
FGF2	2247	broad.mit.edu	37	4	123748299	123748300	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:123748299_123748300insC	ENST00000264498.3	+	1	437_438	c.369_370insC	c.(367-372)gcggggfs	p.AG123fs		NM_002006.4	NP_001997.5	P09038	FGF2_HUMAN	fibroblast growth factor 2 (basic)	123					activation of MAPK activity|branching involved in ureteric bud morphogenesis|cell migration involved in sprouting angiogenesis|chemotaxis|chondroblast differentiation|embryonic morphogenesis|fibroblast growth factor receptor signaling pathway|inositol phosphate biosynthetic process|insulin receptor signaling pathway|negative regulation of blood vessel endothelial cell migration|negative regulation of cell death|organ morphogenesis|phosphatidylinositol biosynthetic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cardiac muscle cell proliferation|positive regulation of cell division|positive regulation of cell fate specification|positive regulation of ERK1 and ERK2 cascade|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phospholipase C activity|Ras protein signal transduction|release of sequestered calcium ion into cytosol|wound healing	extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|ligand-dependent nuclear receptor transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(3)|ovary(1)|skin(1)	8					Pentosan Polysulfate(DB00686)	CTCCAGCGGCTCGGGGATCCCG	0.842													2	4	---	---	---	---					
RP13-16H11.2	0	broad.mit.edu	37	10	26958525	26958527	+	RNA	DEL	AAG	AAG	-	rs61245710		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:26958525_26958527delAAG	ENST00000446557.1	-	0	44																											aagaaaagaaaagaagaaGAATC	0.335													3	6	---	---	---	---					
SLC16A12	387700	broad.mit.edu	37	10	91203593	91203605	+	Frame_Shift_Del	DEL	TCCACAAAAAAAA	TCCACAAAAAAAA	-			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:91203593_91203605delTCCACAAAAAAAA	ENST00000341233.4	-	4	512_524	c.122_134delTTTTTTTTGTGGA	c.(121-135)agfs	p.IFFVE41fs	SLC16A12_ENST00000371790.4_Frame_Shift_Del_p.IFFVE71fs	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	41						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						TGTCTGGAACTCCACAAAAAAAATTGAGATACA	0.371													12	73	---	---	---	---					
PRDM11	56981	broad.mit.edu	37	11	45246125	45246126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:45246125_45246126insC	ENST00000263765.4	+	8	1451_1452	c.1202_1203insC	c.(1201-1203)gccfs	p.A401fs	CTD-2560E9.3_ENST00000527450.1_RNA|PRDM11_ENST00000530656.1_Frame_Shift_Ins_p.A401fs|PRDM11_ENST00000528980.1_Intron|PRDM11_ENST00000424263.2_Frame_Shift_Ins_p.A367fs			Q9NQV5	PRD11_HUMAN	PR domain containing 11	401										endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						GACTGGAAGGTCCCCCAGGGGG	0.579													7	255	---	---	---	---					
PCNXL3	399909	broad.mit.edu	37	11	65385820	65385821	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:65385820_65385821insC	ENST00000355703.3	+	6	1526_1527	c.987_988insC	c.(985-990)ggcagcfs	p.S330fs		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	330						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CCCCAGGGGGGCCAGCCCCTGA	0.634													9	89	---	---	---	---					
RP11-789A21.1	0	broad.mit.edu	37	14	85695100	85695101	+	RNA	DEL	AC	AC	-	rs58894030	by1000genomes	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:85695100_85695101delAC	ENST00000556016.1	-	0	209																											atgtatatatacacacacacac	0.332													3	3	---	---	---	---					
CHEK2P2	646096	broad.mit.edu	37	15	20490739	20490739	+	RNA	DEL	G	G	-	rs143465906		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:20490739delG	ENST00000555186.1	+	0	568					NR_038836.1																						GTTACAACCTGtttttttttt	0.423													7	100	---	---	---	---					
PLA2G4E	123745	broad.mit.edu	37	15	42302338	42302338	+	Frame_Shift_Del	DEL	A	A	-	rs28736629		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:42302338delA	ENST00000413860.2	-	1	107	c.108delT	c.(106-108)ggfs	p.G38fs	PLA2G4E_ENST00000399518.3_Intron			Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	0	C2.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity	p.A39fs*19(1)		NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		TGGCCCCCCCACCCCGGGCCT	0.592													8	114	---	---	---	---					
FFAR2	2867	broad.mit.edu	37	19	35940788	35940790	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:35940788_35940790delCTG	ENST00000599180.1	+	2	252_254	c.172_174delCTG	c.(172-174)del	p.L62del	FFAR2_ENST00000601590.1_Intron|FFAR2_ENST00000246549.2_In_Frame_Del_p.L62del			O15552	FFAR2_HUMAN	free fatty acid receptor 2	62						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGACCTCCTCCTGCTGCTGCTGC	0.645													8	90	---	---	---	---					
SIGLEC8	27181	broad.mit.edu	37	19	51961617	51961619	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:51961617_51961619delGCA	ENST00000321424.3	-	1	89_91	c.23_25delTGC	c.(22-27)ccc>c	p.LP8del	SIGLEC8_ENST00000430817.1_In_Frame_Del_p.LP8del|SIGLEC8_ENST00000340550.5_In_Frame_Del_p.LP8del	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	8					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CAGagcaggggcagcagcagcag	0.596													7	140	---	---	---	---					
AP5S1	55317	broad.mit.edu	37	20	3804563	3804564	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:3804563_3804564insC	ENST00000246041.2	+	3	441_442	c.222_223insC	c.(220-225)cgccccfs	p.RP74fs	AP5S1_ENST00000379567.2_Frame_Shift_Ins_p.RP74fs|AP5S1_ENST00000379573.2_3'UTR			Q9NUS5	CT029_HUMAN	adaptor-related protein complex 5, sigma 1 subunit	74					double-strand break repair via homologous recombination		protein binding										CATCTGGCCGGCCCCCCATGGA	0.639													7	60	---	---	---	---					
