Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PHACTR3	116154	broad.mit.edu	37	20	58342414	58342414	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:58342414C>T	ENST00000371015.1	+	5	1182	c.715C>T	c.(715-717)Ccc>Tcc	p.P239S	PHACTR3_ENST00000359926.3_Missense_Mutation_p.P236S|PHACTR3_ENST00000395636.2_Missense_Mutation_p.P198S|PHACTR3_ENST00000395639.4_Intron|PHACTR3_ENST00000355648.4_Missense_Mutation_p.P198S|PHACTR3_ENST00000361300.4_Intron|PHACTR3_ENST00000541461.1_Missense_Mutation_p.P198S	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	239	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CACTCCGCCACCCAAGGCAAG	0.582000													21	24					0	0	0.002299	0	0
TTN	7273	broad.mit.edu	37	2	179452482	179452482	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179452482A>G	ENST00000589042.1	-	306	63778	c.63554T>C	c.(63553-63555)aTa>aCa	p.I21185T	TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.I12245T|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I12312T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.I12120T|TTN_ENST00000591111.1_Missense_Mutation_p.I19544T|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.I18617T|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19544	Fibronectin type-III 53.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTCTCACTATGACCAGTTT	0.433000													24	41					0	0	0.006320	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709211	128709211	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:128709211C>G	ENST00000392665.2	-	2	1072	c.928G>C	c.(928-930)Gta>Cta	p.V310L	KCNJ1_ENST00000440599.2_Missense_Mutation_p.V310L|KCNJ1_ENST00000392666.1_Missense_Mutation_p.V310L|KCNJ1_ENST00000324036.3_Missense_Mutation_p.V310L|KCNJ1_ENST00000392664.2_Missense_Mutation_p.V329L	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	329					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	GTCTTGGATACTATGGGAGCA	0.493000													44	37					0	0	0.002852	0	0
GPC5	2262	broad.mit.edu	37	13	92408604	92408604	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:92408604C>T	ENST00000377067.3	+	5	1582	c.1210C>T	c.(1210-1212)Cag>Tag	p.Q404*	GPC5_ENST00000483422.1_3'UTR	NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	404						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TCTAGCTGATCAGCTTTGTGC	0.373000													27	62					0	0	0.007291	0	0
THOC2	57187	broad.mit.edu	37	X	122774415	122774415	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chrX:122774415T>C	ENST00000245838.8	-	16	1751	c.1720A>G	c.(1720-1722)Agc>Ggc	p.S574G	THOC2_ENST00000491737.1_Missense_Mutation_p.S459G|THOC2_ENST00000355725.4_Missense_Mutation_p.S574G	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	574					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						GTTGGATTGCTGTGGCTCAAC	0.383000													60	5					0	0	0.003610	0	0
ADCY2	108	broad.mit.edu	37	5	7789843	7789843	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:7789843G>A	ENST00000338316.4	+	20	2647	c.2558G>A	c.(2557-2559)cGc>cAc	p.R853H	ADCY2_ENST00000537121.1_Missense_Mutation_p.R673H	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	853					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						AACCTGAACCGCGTGCTGCTG	0.532000													35	77					0	0	0.003755	0	0
NAIF1	203245	broad.mit.edu	37	9	130829161	130829161	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:130829161C>G	ENST00000373078.4	-	1	439	c.220G>C	c.(220-222)Gac>Cac	p.D74H		NM_197956.3	NP_931045.1	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	74					apoptosis|induction of apoptosis	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GTCTTGAGGTCAGACCACTTC	0.697000													83	12					0	0	0.003610	0	0
PI4KA	5297	broad.mit.edu	37	22	21178651	21178651	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr22:21178651G>A	ENST00000255882.6	-	4	505	c.419C>T	c.(418-420)tCt>tTt	p.S140F	PI4KA_ENST00000572273.1_Missense_Mutation_p.S82F	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	82					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GGCCACATCAGACAGCAGAGT	0.443000													18	33					0	0	0.002299	0	0
CYP4F8	11283	broad.mit.edu	37	19	15733053	15733053	+	RNA	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:15733053G>C	ENST00000441682.2	+	0	611							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CCTGGCCATGGAGGGCAGCAC	0.587000													16	27					0	0	0.004007	0	0
GSE1	23199	broad.mit.edu	37	16	85687969	85687969	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:85687969C>T	ENST00000253458.7	+	4	688	c.512C>T	c.(511-513)gCc>gTc	p.A171V	GSE1_ENST00000393243.1_Missense_Mutation_p.A98V|GSE1_ENST00000405402.2_Missense_Mutation_p.A67V	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		GGGGGACCAGCCATCCCCTCG	0.667000													9	17					0	0	0.000673	0	0
MYO9B	4650	broad.mit.edu	37	19	17309083	17309083	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:17309083G>A	ENST00000595618.1	+	24	4356	c.4204G>A	c.(4204-4206)Gca>Aca	p.A1402T	MYO9B_ENST00000594824.1_Missense_Mutation_p.A1402T|MYO9B_ENST00000397274.2_Missense_Mutation_p.A1402T	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1402	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						CCTCCCAGACGCAGGGCTGTC	0.627000													17	37					0	0	0.006122	0	0
SLIT3	6586	broad.mit.edu	37	5	168112761	168112761	+	Silent	SNP	G	G	A	rs148625020		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:168112761G>A	ENST00000519560.1	-	31	3905	c.3486C>T	c.(3484-3486)ttC>ttT	p.F1162F	SLIT3_ENST00000404867.3_Silent_p.F1162F|SLIT3_ENST00000332966.8_Silent_p.F1169F	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1162	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding	p.F1162F(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTTGCCCACGAAGTTGACAG	0.657000													24	14					0	0	0.003330	0	0
CDK8	1024	broad.mit.edu	37	13	26967609	26967609	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:26967609A>G	ENST00000381527.3	+	7	1255	c.752A>G	c.(751-753)cAg>cGg	p.Q251R	CDK8_ENST00000536792.1_3'UTR	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	251	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CACCATGACCAGCTGGACAGA	0.363000													73	109					0	0	0.003610	0	0
ATAD2B	54454	broad.mit.edu	37	2	24056880	24056880	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:24056880C>A	ENST00000238789.5	-	14	1980	c.1637G>T	c.(1636-1638)gGt>gTt	p.G546V		NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	546							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTTGTAGCACCAATAACAAC	0.383000													13	24					4.3838e-07	2.34754e-06	0.001855	1	0
KIAA1161	57462	broad.mit.edu	37	9	34371549	34371549	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:34371549C>G	ENST00000297625.7	-	2	1516	c.1291G>C	c.(1291-1293)Ggc>Cgc	p.G431R		NM_020702.3	NP_065753.2	Q6NSJ0	K1161_HUMAN	KIAA1161	465					carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CTGACCTCGCCCGCGTCGAAC	0.672000													2	7					0	0	0.004672	0	0
BRDT	676	broad.mit.edu	37	1	92446620	92446620	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:92446620C>A	ENST00000370389.2	+	10	2340	c.1416C>A	c.(1414-1416)agC>agA	p.S472R	BRDT_ENST00000362005.3_Missense_Mutation_p.S545R|BRDT_ENST00000402388.1_Missense_Mutation_p.S545R|BRDT_ENST00000399546.2_Missense_Mutation_p.S545R|BRDT_ENST00000394530.3_Missense_Mutation_p.S499R	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		CTTCTCTGAGCAATTCCAATC	0.368000													29	11					1.50538e-07	8.10934e-07	0.006320	1	0
CNTN5	53942	broad.mit.edu	37	11	100169994	100169994	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:100169994C>T	ENST00000524871.1	+	20	2776	c.2486C>T	c.(2485-2487)tCt>tTt	p.S829F	CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000528682.1_Missense_Mutation_p.S829F|CNTN5_ENST00000527185.1_Missense_Mutation_p.S829F|CNTN5_ENST00000279463.3_Missense_Mutation_p.S829F|CNTN5_ENST00000418526.2_Missense_Mutation_p.S755F	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	829	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTGACATCCTCTGAAGCTTCC	0.433000													46	11					0	0	0.002522	0	0
AGMO	392636	broad.mit.edu	37	7	15599809	15599809	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:15599809C>A	ENST00000342526.3	-	2	383	c.214G>T	c.(214-216)Gct>Tct	p.A72S		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	72					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						GACGTTAAAGCATCATCCAGG	0.443000													85	68					4.45923e-32	2.58692e-31	0.003610	1	0
LAMA1	284217	broad.mit.edu	37	18	6976021	6976021	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:6976021G>A	ENST00000389658.3	-	45	6497	c.6404C>T	c.(6403-6405)tCc>tTc	p.S2135F		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2135	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTGGTAGAGGAAATCTGAGG	0.453000													5	54					0	0	0.000602	0	0
SLC7A6OS	84138	broad.mit.edu	37	16	68336300	68336300	+	Silent	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:68336300T>C	ENST00000263997.6	-	4	801	c.783A>G	c.(781-783)ggA>ggG	p.G261G		NM_032178.2	NP_115554.2	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite strand	261					protein transport	cytoplasm|nucleus				breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		AATCCTCATCTCCATCACTGC	0.517000													80	100					0	0	0.003610	0	0
TECTA	7007	broad.mit.edu	37	11	121058640	121058640	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:121058640C>T	ENST00000392793.1	+	21	6370	c.6099C>T	c.(6097-6099)taC>taT	p.Y2033Y	TECTA_ENST00000264037.2_Silent_p.Y2033Y			O75443	TECTA_HUMAN	tectorin alpha	2033	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAGGGGATTACGACGAAGTTC	0.453000													72	15					0	0	0.003610	0	0
KRT78	196374	broad.mit.edu	37	12	53237950	53237950	+	Missense_Mutation	SNP	G	G	A	rs145166082		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:53237950G>A	ENST00000359499.4	-	6	655	c.644C>T	c.(643-645)aCg>aTg	p.T215M	KRT78_ENST00000304620.4_Missense_Mutation_p.T325M			Q8N1N4	K2C78_HUMAN	keratin 78	325	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						CTGGACTTTCGTTTCCTGCAT	0.527000													81	96					0	0	0.003610	0	0
CDHR5	53841	broad.mit.edu	37	11	621106	621106	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:621106C>T	ENST00000358353.3	-	8	1085	c.763G>A	c.(763-765)Ggg>Agg	p.G255R	CDHR5_ENST00000349570.7_Missense_Mutation_p.G255R|CDHR5_ENST00000397542.2_Missense_Mutation_p.G255R			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	255	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GGGACAGCCCCGTGGTACTGA	0.652000													24	29					0	0	0.003330	0	0
OR4C6	219432	broad.mit.edu	37	11	55433051	55433051	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:55433051C>T	ENST00000314259.3	+	1	438	c.409C>T	c.(409-411)Cgg>Tgg	p.R137W		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						CATGAGTCCACGGGTGTGCTG	0.512000													48	18					0	0	0.003610	0	0
PGAP3	93210	broad.mit.edu	37	17	37842182	37842182	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:37842182T>A	ENST00000300658.4	-	2	364	c.272A>T	c.(271-273)cAt>cTt	p.H91L	PGAP3_ENST00000429199.2_Missense_Mutation_p.H91L|PGAP3_ENST00000378011.4_Missense_Mutation_p.H91L|PGAP3_ENST00000579146.1_Missense_Mutation_p.H91L	NM_033419.3	NP_219487.3	Q96FM1	PGAP3_HUMAN	post-GPI attachment to proteins 3	91					GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12						CACCTTGCCATGGAACTGAGG	0.537000													13	17					0	0	0.001855	0	0
SUPT5H	6829	broad.mit.edu	37	19	39964118	39964118	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:39964118C>A	ENST00000599117.1	+	26	2816	c.2449C>A	c.(2449-2451)Cag>Aag	p.Q817K	SUPT5H_ENST00000402194.2_Missense_Mutation_p.Q813K|SUPT5H_ENST00000432763.2_Missense_Mutation_p.Q817K|SUPT5H_ENST00000359191.6_Missense_Mutation_p.Q813K|SUPT5H_ENST00000598725.1_Missense_Mutation_p.Q817K			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	817	9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CACTCCTGCCCAGAGTGGGGC	0.622000													29	14					7.26314e-15	4.0326e-14	0.007291	1	0
SERINC1	57515	broad.mit.edu	37	6	122766322	122766322	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:122766322T>C	ENST00000368454.1	-	12	1558	c.1229A>G	c.(1228-1230)tAt>tGt	p.Y410C	SERINC1_ENST00000339697.3_Missense_Mutation_p.Y410C			Q9NRX5	SERC1_HUMAN	serine incorporator 1	410					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(1)	13				GBM - Glioblastoma multiforme(226;0.126)		AGAGGGTTCATACCTAAAATT	0.428000													17	15					0	0	0.004007	0	0
MYO5B	4645	broad.mit.edu	37	18	47390534	47390534	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:47390534G>A	ENST00000285039.7	-	28	4119	c.3820C>T	c.(3820-3822)Cgg>Tgg	p.R1274W	MYO5B_ENST00000324581.6_Missense_Mutation_p.R415W|MYO5B_ENST00000587895.1_5'UTR	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1274					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GCGAGTCGCCGCTGGTCGGCG	0.617000													23	31					0	0	0.002780	0	0
LAMA2	3908	broad.mit.edu	37	6	129826387	129826387	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:129826387G>C	ENST00000421865.2	+	61	8639	c.8590G>C	c.(8590-8592)Gat>Cat	p.D2864H		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2864	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCTTTATGTAGATGGGGCTTC	0.413000													34	35					0	0	0.002096	0	0
RNF39	80352	broad.mit.edu	37	6	30043353	30043353	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:30043353G>A	ENST00000244360.6	-	1	311	c.214C>T	c.(214-216)Ccc>Tcc	p.P72S	RNF39_ENST00000376751.3_Missense_Mutation_p.P72S	NM_025236.3	NP_079512.2	Q9H2S5	RNF39_HUMAN	ring finger protein 39	72						cytoplasm	zinc ion binding										CCCAGCTCGGGCGCATCCATG	0.711000													10	7					0	0	0.000673	0	0
CCL1	6346	broad.mit.edu	37	17	32688843	32688843	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:32688843T>G	ENST00000225842.3	-	2	218	c.149A>C	c.(148-150)tAc>tCc	p.Y50S		NM_002981.1	NP_002972.1	P22362	CCL1_HUMAN	chemokine (C-C motif) ligand 1	50					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity						Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GGTATTTCTGTAACACAGGAT	0.493000											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	110					0	0	0.003610	0	0
BAG3	9531	broad.mit.edu	37	10	121411327	121411327	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:121411327C>T	ENST00000369085.3	+	1	446	c.140C>T	c.(139-141)aCt>aTt	p.T47I		NM_004281.3	NP_004272.2	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	47	WW 1.				anti-apoptosis|apoptosis|protein folding	cytosol				endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(5)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	20		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AGCCGCACCACTACGTGGAAC	0.726000													24	17					0	0	0.003954	0	0
KIAA1407	57577	broad.mit.edu	37	3	113721347	113721347	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:113721347G>A	ENST00000295878.3	-	12	2163	c.2017C>T	c.(2017-2019)Cgg>Tgg	p.R673W	KIAA1407_ENST00000545063.1_3'UTR	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	673										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						GCCAAGATCCGCCTACATTCA	0.328000													38	8					0	0	0.002522	0	0
FAM84B	157638	broad.mit.edu	37	8	127569333	127569333	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:127569333G>A	ENST00000304916.3	-	2	757	c.302C>T	c.(301-303)tCg>tTg	p.S101L	RP11-103H7.5_ENST00000524320.1_RNA	NM_174911.4	NP_777571.1	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	101						cytoplasm|plasma membrane	protein binding			lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			CAGCGCCGCCGAGCCCGGCGC	0.657000													31	17					0	0	0.003271	0	0
TMPO	7112	broad.mit.edu	37	12	98928061	98928061	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:98928061G>A	ENST00000266732.4	+	4	2264	c.2026G>A	c.(2026-2028)Gga>Aga	p.G676R	TMPO_ENST00000261210.5_Intron|TMPO_ENST00000556029.1_Intron|TMPO_ENST00000393053.2_Intron|TMPO_ENST00000343315.5_Intron	NM_003276.2	NP_003267.1	P42167	LAP2B_HUMAN	thymopoietin	0						integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CTTTAAAGGTGGAACATTATT	0.368000													24	237					0	0	0.004656	0	0
OR52A5	390054	broad.mit.edu	37	11	5153166	5153166	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:5153166G>A	ENST00000307388.1	-	1	706	c.707C>T	c.(706-708)gCa>gTa	p.A236V		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CTTGAATCGTGCCTCCTTCTG	0.408000													14	35					0	0	0.001855	0	0
FLT1	2321	broad.mit.edu	37	13	28913349	28913349	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:28913349T>C	ENST00000282397.4	-	17	2695	c.2444A>G	c.(2443-2445)tAt>tGt	p.Y815C	FLT1_ENST00000540678.1_Missense_Mutation_p.Y33C	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	815					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCTGGCATCATAAGGGAGCCG	0.398000													21	38					0	0	0.003954	0	0
CCDC180	100499483	broad.mit.edu	37	9	100090306	100090306	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:100090306G>T	ENST00000375202.2	+	30	3150	c.1798G>T	c.(1798-1800)Gaa>Taa	p.E600*	CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000411667.2_Nonsense_Mutation_p.E597*|CCDC180_ENST00000460482.2_3'UTR|CCDC180_ENST00000529487.1_Nonsense_Mutation_p.E600*|CCDC180_ENST00000357054.1_Nonsense_Mutation_p.E739*|RP11-23J9.4_ENST00000534123.1_RNA					coiled-coil domain containing 180																		TCCCAGGTATGAATGTTTTCA	0.517000													86	118					2.61895e-37	1.53906e-36	0.003610	1	0
MYL12B	103910	broad.mit.edu	37	18	3273065	3273065	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:3273065A>G	ENST00000581193.1	+	2	552	c.169A>G	c.(169-171)Atg>Gtg	p.M57V	MYL12B_ENST00000400175.5_Missense_Mutation_p.M57V|MYL12B_ENST00000584539.1_Missense_Mutation_p.M57V|MYL12B_ENST00000237500.5_Missense_Mutation_p.M57V	NM_001144945.1	NP_001138417.1	O14950	ML12B_HUMAN	myosin, light chain 12B, regulatory	57	EF-hand 1.				axon guidance|muscle contraction	cytosol|myosin complex	calcium ion binding			breast(1)|large_intestine(1)|lung(2)	4						TTTGCATGATATGCTTGCTTC	0.343000													98	24					0	0	0.003610	0	0
REG3A	5068	broad.mit.edu	37	2	79385863	79385863	+	Silent	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:79385863G>T	ENST00000393878.1	-	2	363	c.109C>A	c.(109-111)Cgg>Agg	p.R37R	REG3A_ENST00000409839.3_Silent_p.R37R|REG3A_ENST00000305165.2_Silent_p.R37R|AC011754.1_ENST00000415201.1_RNA	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	37					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						CAGCGGATCCGTGCAGAGGGC	0.552000													14	28					1.49906e-05	7.88749e-05	0.002450	1	0
ZNF730	100129543	broad.mit.edu	37	19	23329204	23329204	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:23329204A>G	ENST00000597761.2	+	4	1557	c.1358A>G	c.(1357-1359)gAa>gGa	p.E453G		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						AAACCCTATGAATGTGAAGAA	0.393000													24	30					0	0	0.002780	0	0
PRKCB	5579	broad.mit.edu	37	16	24196444	24196444	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:24196444C>T	ENST00000303531.7	+	14	1698	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	PRKCB_ENST00000321728.7_Nonsense_Mutation_p.Q516*	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	516	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	AATTGCTTATCAGCCCTATGG	0.433000													5	84					0	0	0.001984	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140812032	140812032	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:140812032C>T	ENST00000252085.3	+	1	1848	c.1706C>T	c.(1705-1707)aCg>aTg	p.T569M	PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTCCCCACGGACGGTTCC	0.677000													91	42					0	0	0.003610	0	0
BCAT1	586	broad.mit.edu	37	12	25047338	25047338	+	Silent	SNP	T	T	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:25047338T>G	ENST00000261192.7	-	3	676	c.150A>C	c.(148-150)ggA>ggC	p.G50G	BCAT1_ENST00000539282.1_Silent_p.G62G|BCAT1_ENST00000342945.5_Silent_p.G26G|BCAT1_ENST00000538118.1_Silent_p.G49G|BCAT1_ENST00000544418.1_5'UTR|BCAT1_ENST00000539780.1_Silent_p.G50G	NM_001178091.1|NM_005504.6	NP_001171562.1|NP_005495.2	P54687	BCAT1_HUMAN	branched chain amino-acid transaminase 1, cytosolic	50					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			breast(1)|large_intestine(1)|lung(3)|prostate(2)	7	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	TGAACACAGTTCCAAAAACCA	0.438000													5	15					0	0	0.000602	0	0
GOLGA3	2802	broad.mit.edu	37	12	133384625	133384625	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:133384625T>C	ENST00000204726.3	-	5	1588	c.1030A>G	c.(1030-1032)Atg>Gtg	p.M344V	GOLGA3_ENST00000545875.1_Missense_Mutation_p.M344V|GOLGA3_ENST00000456883.2_Missense_Mutation_p.M344V|GOLGA3_ENST00000450791.2_Missense_Mutation_p.M344V|GOLGA3_ENST00000537452.1_Missense_Mutation_p.M344V	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	344					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCGTTGACCATATAGGGGGTG	0.612000													33	38					0	0	0.002096	0	0
ITGAV	3685	broad.mit.edu	37	2	187506311	187506311	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:187506311C>T	ENST00000261023.3	+	12	1429	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	ITGAV_ENST00000433736.2_Silent_p.F339F|AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000374907.3_Silent_p.F349F	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	385					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		AGGATGGTTTCAATGGTAAGA	0.463000													59	77					0	0	0.003610	0	0
LAD1	3898	broad.mit.edu	37	1	201356297	201356297	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:201356297G>A	ENST00000391967.2	-	3	493	c.192C>T	c.(190-192)agC>agT	p.S64S	LAD1_ENST00000367313.3_Silent_p.S78S	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	64						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CTTCTTCCACGCTCGGTAGTC	0.557000													21	47					0	0	0.003330	0	0
CCAR1	55749	broad.mit.edu	37	10	70514524	70514524	+	Silent	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:70514524T>A	ENST00000265872.6	+	12	1517	c.1398T>A	c.(1396-1398)gcT>gcA	p.A466A	CCAR1_ENST00000543719.1_Silent_p.A451A|CCAR1_ENST00000535016.1_Silent_p.A451A	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	466					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						AGTCATGTGCTCTTGCTGAGG	0.358000													32	44					0	0	0.004289	0	0
ZNF493	284443	broad.mit.edu	37	19	21606219	21606219	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:21606219C>G	ENST00000392288.2	+	4	867	c.758C>G	c.(757-759)aCt>aGt	p.T253S	ZNF493_ENST00000355504.4_Missense_Mutation_p.T125S|CTD-2561J22.3_ENST00000600810.1_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						TCAAACCTTACTACACATAAG	0.373000													13	36					0	0	0.001368	0	0
ZNF716	441234	broad.mit.edu	37	7	57529191	57529191	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:57529191C>T	ENST00000420713.1	+	4	1136	c.1024C>T	c.(1024-1026)Cat>Tat	p.H342Y		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						CCTTAAGAAACATAAGATAGT	0.388000													30	16					0	0	0.007291	0	0
LRP1	4035	broad.mit.edu	37	12	57604642	57604642	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:57604642T>C	ENST00000243077.3	+	83	13362	c.12896T>C	c.(12895-12897)cTg>cCg	p.L4299P		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4299	EGF-like 19.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCGGCTTCCTGGGCGACCGC	0.647000													3	36					0	0	0.004672	0	0
GRM3	2913	broad.mit.edu	37	7	86493648	86493648	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:86493648G>A	ENST00000361669.2	+	6	3716	c.2617G>A	c.(2617-2619)Gac>Aac	p.D873N	GRM3_ENST00000439827.1_Missense_Mutation_p.R517Q|GRM3_ENST00000546348.1_Missense_Mutation_p.D465N|GRM3_ENST00000536043.1_Missense_Mutation_p.D745N|GRM3_ENST00000394720.2_Missense_Mutation_p.R515Q	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	873					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGAAGTCCTCGACTCCACCAC	0.468000													73	122					0	0	0.003610	0	0
SLC14A2	8170	broad.mit.edu	37	18	43224005	43224005	+	Missense_Mutation	SNP	C	C	T	rs139770269		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:43224005C>T	ENST00000255226.6	+	10	2047	c.1231C>T	c.(1231-1233)Ctc>Ttc	p.L411F	SLC14A2_ENST00000586448.1_Missense_Mutation_p.L411F	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	411						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CATCTTCCTGCTCCTGACGAC	0.547000													73	103					0	0	0.003610	0	0
POM121	9883	broad.mit.edu	37	7	72413673	72413673	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:72413673C>T	ENST00000395270.1	+	14	3387	c.2346C>T	c.(2344-2346)ttC>ttT	p.F782F	POM121_ENST00000446813.1_Silent_p.F782F|POM121_ENST00000434423.2_Silent_p.F1047F|POM121_ENST00000257622.4_Silent_p.F782F|POM121_ENST00000358357.3_Silent_p.F782F	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1047	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CTTCGGCCTTCGGCGCTCCCG	0.647000													7	199					0	0	0.002450	0	0
F5	2153	broad.mit.edu	37	1	169511140	169511140	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:169511140C>T	ENST00000367796.3	-	13	3404	c.3203G>A	c.(3202-3204)aGa>aAa	p.R1068K	F5_ENST00000367797.3_Missense_Mutation_p.R1063K			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1063	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATGCTTAAGTCTTCTTTCTGA	0.423000													66	130					0	0	0.003610	0	0
DOCK4	9732	broad.mit.edu	37	7	111540505	111540505	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:111540505C>T	ENST00000428084.1	-	15	1677	c.1405G>A	c.(1405-1407)Gaa>Aaa	p.E469K	DOCK4_ENST00000476846.1_5'UTR|DOCK4_ENST00000437633.1_Missense_Mutation_p.E469K			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	469	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TTCAGCAGTTCAGACCACCTG	0.498000													14	15					0	0	0.001855	0	0
TTLL4	9654	broad.mit.edu	37	2	219612322	219612322	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:219612322A>G	ENST00000392102.1	+	11	2592	c.2252A>G	c.(2251-2253)tAt>tGt	p.Y751C	TTLL4_ENST00000442769.1_Missense_Mutation_p.Y687C|TTLL4_ENST00000457313.1_Missense_Mutation_p.Y586C|TTLL4_ENST00000258398.4_Missense_Mutation_p.Y751C	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	751	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTATGTAGGTATCTACACAAA	0.478000													54	23					0	0	0.003610	0	0
RBBP6	5930	broad.mit.edu	37	16	24580072	24580072	+	Silent	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:24580072A>G	ENST00000319715.4	+	17	2493	c.2061A>G	c.(2059-2061)aaA>aaG	p.K687K	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Silent_p.K653K	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	687					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TTAGGTCTAAATCTCCCTATA	0.343000													17	37					0	0	0.004007	0	0
RLTPR	146206	broad.mit.edu	37	16	67682065	67682065	+	Silent	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:67682065C>A	ENST00000334583.6	+	14	1510	c.1182C>A	c.(1180-1182)acC>acA	p.T394T	RLTPR_ENST00000545661.1_Intron	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	394										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GATGGATGACCGGCAGGGCGG	0.687000													10	11					3.07112e-06	1.63492e-05	0.000978	1	0
G6PC2	57818	broad.mit.edu	37	2	169764494	169764494	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:169764494T>A	ENST00000375363.3	+	5	1065	c.973T>A	c.(973-975)Ttt>Att	p.F325I	SPC25_ENST00000472216.2_Intron|G6PC2_ENST00000461586.1_3'UTR	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	325					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						TGTGCTGTCTTTTTGTAAAAG	0.433000													23	138					0	0	0.002780	0	0
ASTN2	23245	broad.mit.edu	37	9	119976967	119976967	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:119976967C>T	ENST00000313400.4	-	3	785	c.685G>A	c.(685-687)Gcc>Acc	p.A229T	ASTN2_ENST00000373996.3_Missense_Mutation_p.A229T|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.A229T			O75129	ASTN2_HUMAN	astrotactin 2	229			A -> V (found in a clear cell renal carcinoma case; somatic mutation).			integral to membrane		p.A229T(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CGTCGCTGGGCGTACAGCGCC	0.607000													31	36					0	0	0.001786	0	0
XIRP2	129446	broad.mit.edu	37	2	168103945	168103945	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:168103945G>C	ENST00000409195.1	+	9	6132	c.6043G>C	c.(6043-6045)Gag>Cag	p.E2015Q	XIRP2_ENST00000409273.1_Missense_Mutation_p.E1793Q|XIRP2_ENST00000295237.9_Missense_Mutation_p.E2015Q|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1840					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGAAAGAACTGAGGTTAATCT	0.438000													24	30					0	0	0.002299	0	0
CD33	945	broad.mit.edu	37	19	51728579	51728579	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:51728579C>T	ENST00000262262.4	+	2	164	c.143C>T	c.(142-144)cCc>cTc	p.P48L	CD33_ENST00000436584.2_Intron|CD33_ENST00000421133.2_Intron|CD33_ENST00000391796.3_Missense_Mutation_p.P48L	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	48	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CATCCCATACCCTACTACGAC	0.517000													11	66					0	0	0.001368	0	0
GSE1	23199	broad.mit.edu	37	16	85687968	85687968	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:85687968G>T	ENST00000253458.7	+	4	687	c.511G>T	c.(511-513)Gcc>Tcc	p.A171S	GSE1_ENST00000393243.1_Missense_Mutation_p.A98S|GSE1_ENST00000405402.2_Missense_Mutation_p.A67S	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		AGGGGGACCAGCCATCCCCTC	0.667000													8	17					2.17888e-05	0.000113982	0.006214	1	0
SLCO2A1	6578	broad.mit.edu	37	3	133666147	133666147	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:133666147G>C	ENST00000310926.4	-	9	1521	c.1248C>G	c.(1246-1248)ttC>ttG	p.F416L	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.F340L	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	416					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						ATCCCATGAAGAACAAAGGAA	0.493000													36	55					0	0	0.004878	0	0
CD93	22918	broad.mit.edu	37	20	23065386	23065386	+	Missense_Mutation	SNP	C	C	T	rs142122866		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:23065386C>T	ENST00000246006.4	-	1	1591	c.1444G>A	c.(1444-1446)Gat>Aat	p.D482N		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	482					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCCTCCTCATCGGGGGGCCCA	0.657000													35	40					0	0	0.002836	0	0
TTN	7273	broad.mit.edu	37	2	179604933	179604933	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179604933C>G	ENST00000589042.1	-	48	13251	c.13027G>C	c.(13027-13029)Gaa>Caa	p.E4343Q	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E4105Q|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E4172Q|TTN_ENST00000460472.2_Missense_Mutation_p.E3980Q|TTN_ENST00000591111.1_Missense_Mutation_p.E4026Q|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4026	Ig-like 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAATGCTCTTCTTTGAGCAGT	0.473000													52	72					0	0	0.003610	0	0
PRDM9	56979	broad.mit.edu	37	5	23526620	23526620	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:23526620G>A	ENST00000296682.3	+	11	1605	c.1423G>A	c.(1423-1425)Gcc>Acc	p.A475T		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	475					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GATTTCAAGGGCCTTTTCTAG	0.453000										HNSCC(3;0.000094)			10	23					0	0	0.006214	0	0
TMEM132E	124842	broad.mit.edu	37	17	32953362	32953362	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:32953362G>A	ENST00000321639.5	+	2	612	c.284G>A	c.(283-285)gGg>gAg	p.G95E		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	95						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		GTCTCTCTGGGGCCCTTCAGC	0.697000													8	24					0	0	0.004482	0	0
MUC5B	727897	broad.mit.edu	37	11	1261156	1261156	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:1261156G>A	ENST00000447027.1	+	28	3778	c.3720G>A	c.(3718-3720)gcG>gcA	p.A1240A	MUC5B_ENST00000529681.1_Silent_p.A1237A			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1237	Cys-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCCCACAGCGGAGAACTGCC	0.657000													6	20					0	0	0.001984	0	0
KIF2B	84643	broad.mit.edu	37	17	51901863	51901863	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:51901863C>A	ENST00000268919.4	+	1	1625	c.1469C>A	c.(1468-1470)cCt>cAt	p.P490H		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	490					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAGAACAAGCCTCACACCCCA	0.527000													15	27					2.31682e-05	0.000120501	0.003163	1	0
SPEN	23013	broad.mit.edu	37	1	16258889	16258889	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:16258889A>T	ENST00000375759.3	+	11	6358	c.6154A>T	c.(6154-6156)Aaa>Taa	p.K2052*		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2052					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGGCACAGACAAAAACCCCCC	0.502000													28	10					0	0	0.005443	0	0
SAP130	79595	broad.mit.edu	37	2	128747419	128747419	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:128747419G>C	ENST00000357702.5	-	13	1708	c.1577C>G	c.(1576-1578)tCt>tGt	p.S526C	SAP130_ENST00000259235.3_Missense_Mutation_p.S526C|SAP130_ENST00000259234.6_Missense_Mutation_p.S500C	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	526					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TGTGATGGCAGAGTTTGGAGC	0.443000													19	29					0	0	0.001523	0	0
TFEC	22797	broad.mit.edu	37	7	115624462	115624462	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:115624462G>C	ENST00000265440.7	-	2	214	c.34C>G	c.(34-36)Ctt>Gtt	p.L12V	TFEC_ENST00000484212.1_Missense_Mutation_p.L102V|TFEC_ENST00000393485.1_Missense_Mutation_p.L12V|TFEC_ENST00000320239.7_Missense_Mutation_p.L12V	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	12	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity	p.L12V(1)		NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			GACCATTTAAGAGTTGGATTG	0.493000													54	108					0	0	0.003610	0	0
POLR2A	5430	broad.mit.edu	37	17	7404147	7404147	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:7404147A>G	ENST00000322644.6	+	11	2260	c.1861A>G	c.(1861-1863)Atc>Gtc	p.I621V		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	621					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				TTACAAGCACATCTCTCCTGG	0.537000													31	87					0	0	0.002096	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362339	105362339	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:105362339T>A	ENST00000369774.4	-	15	2912	c.2636A>T	c.(2635-2637)tAt>tTt	p.Y879F	SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.Y746F|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.Y714F|SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.Y851F|SH3PXD2A_ENST00000427662.2_Intron			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	879	SH3 4.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		AAACCTCACATACCACCACCC	0.612000													29	34					0	0	0.006320	0	0
NBPF1	55672	broad.mit.edu	37	1	16893786	16893786	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:16893786T>A	ENST00000430580.2	-	25	3614	c.2727A>T	c.(2725-2727)agA>agT	p.R909S	NBPF1_ENST00000432949.1_3'UTR|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	909	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TTGAATAACATCTATCCAGTG	0.493000													66	660					0	0	0.003610	0	0
ZC3H13	23091	broad.mit.edu	37	13	46577305	46577305	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:46577305C>G	ENST00000242848.4	-	8	1261	c.913G>C	c.(913-915)Gaa>Caa	p.E305Q	ZC3H13_ENST00000470308.1_5'UTR|ZC3H13_ENST00000282007.3_Missense_Mutation_p.E305Q			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	305							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CTTTGTCGTTCAAAATCTCGT	0.313000													7	154					0	0	0.003080	0	0
TENM4	26011	broad.mit.edu	37	11	78516412	78516412	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:78516412C>A	ENST00000278550.7	-	15	2566	c.2104G>T	c.(2104-2106)Ggc>Tgc	p.G702C		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GTTCCGTGGCCTGAACACTGG	0.607000													6	3					8.12818e-05	0.000417955	0.001984	1	0
NADK	65220	broad.mit.edu	37	1	1686106	1686106	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:1686106C>T	ENST00000344463.4	-	10	1376	c.1155G>A	c.(1153-1155)ctG>ctA	p.L385L	NADK_ENST00000341991.3_Silent_p.L240L|NADK_ENST00000378625.1_Silent_p.L385L|NADK_ENST00000341426.5_Silent_p.L240L|NADK_ENST00000342348.5_Silent_p.L208L			O95544	NADK_HUMAN	NAD kinase	240					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CCCTGACCTTCAGCCGACTCC	0.647000													60	22					0	0	0.003610	0	0
KAT5	10524	broad.mit.edu	37	11	65482325	65482325	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:65482325G>A	ENST00000341318.4	+	8	1207	c.973G>A	c.(973-975)Gag>Aag	p.E325K	KAT5_ENST00000534650.1_Missense_Mutation_p.E81K|KAT5_ENST00000530446.1_Missense_Mutation_p.E273K|KAT5_ENST00000377046.3_Missense_Mutation_p.E292K|KAT5_ENST00000352980.4_Missense_Mutation_p.E240K	NM_182710.2	NP_874369.1	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5	292					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)	21						TCCAGGCAATGAGATTTACCG	0.537000													36	99					0	0	0.005524	0	0
CADM4	199731	broad.mit.edu	37	19	44127586	44127586	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:44127586A>T	ENST00000222374.2	-	9	1111	c.1063T>A	c.(1063-1065)Tat>Aat	p.Y355N		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	355					cell adhesion	integral to membrane				endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				TGGGTCAGATAGGAACCTGAG	0.537000													82	20					0	0	0.003610	0	0
IMPG2	50939	broad.mit.edu	37	3	100963028	100963028	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:100963028G>C	ENST00000193391.7	-	13	2334	c.2147C>G	c.(2146-2148)tCa>tGa	p.S716*		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	716					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TTTGGTAACTGAGTAATCATC	0.473000													14	7					0	0	0.001855	0	0
TIFA	92610	broad.mit.edu	37	4	113199415	113199415	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:113199415G>A	ENST00000361717.2	-	2	439	c.158C>T	c.(157-159)tCc>tTc	p.S53F	TIFA_ENST00000500655.2_Missense_Mutation_p.S53F	NM_052864.2	NP_443096.1	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with forkhead-associated domain	53	FHA.						protein binding			breast(2)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)	6		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		ACAGATGTTGGAATTTCGGCC	0.403000													41	24					0	0	0.001951	0	0
UNC13A	23025	broad.mit.edu	37	19	17763482	17763482	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:17763482C>A	ENST00000428389.2	-	13	1660	c.1661G>T	c.(1660-1662)cGg>cTg	p.R554L	UNC13A_ENST00000551649.1_Missense_Mutation_p.R466L|UNC13A_ENST00000252773.7_Missense_Mutation_p.R466L|UNC13A_ENST00000552293.1_Missense_Mutation_p.R466L|UNC13A_ENST00000550896.1_Missense_Mutation_p.R466L|UNC13A_ENST00000519716.2_Missense_Mutation_p.R466L			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	466					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						TCCTTCTCCCCGGGCCTGCAG	0.572000													101	198					1.43872e-54	8.6228e-54	0.003610	1	0
PARP6	56965	broad.mit.edu	37	15	72534499	72534499	+	Splice_Site	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr15:72534499T>C	ENST00000569795.1	-	22	2391	c.1705_splice	c.e22+1	p.E568_splice	PARP6_ENST00000260376.7_3'UTR|PARP6_ENST00000413097.2_5'UTR|PARP6_ENST00000287196.9_Splice_Site_p.E568_splice			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	568	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						GCTACCTACCTTCACAAAGTG	0.473000													15	9					0	0	0.002450	0	0
C12orf71	728858	broad.mit.edu	37	12	27234247	27234247	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:27234247T>C	ENST00000429849.2	-	2	700	c.670A>G	c.(670-672)Atc>Gtc	p.I224V		NM_001080406.1	NP_001073875.1	A8MTZ7	CL071_HUMAN	chromosome 12 open reading frame 71	224										endometrium(2)|large_intestine(1)|lung(4)|skin(1)	8						GAGGGGAGGATACGCTGCCTC	0.552000													53	73					0	0	0.003610	0	0
ZNF695	57116	broad.mit.edu	37	1	247150864	247150864	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:247150864T>C	ENST00000339986.7	-	4	1100	c.953A>G	c.(952-954)cAt>cGt	p.H318R	ZNF695_ENST00000487338.2_Intron|ZNF695_ENST00000498046.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	318					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTCTCTACTATGAATTCTCTT	0.348000													9	13					0	0	0.000673	0	0
ACPL2	92370	broad.mit.edu	37	3	140998227	140998227	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:140998227C>T	ENST00000508812.1	+	3	2126	c.219C>T	c.(217-219)gcC>gcT	p.A73A	ACPL2_ENST00000504264.1_Silent_p.A65A|ACPL2_ENST00000286353.4_Silent_p.A82A|ACPL2_ENST00000393007.1_Silent_p.A66A|ACPL2_ENST00000393010.2_Silent_p.A82A|RP11-438D8.2_ENST00000507698.1_RNA|ACPL2_ENST00000502783.1_Silent_p.A44A			Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2	82						extracellular region	acid phosphatase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(2)	23						CAGGTCATGCCCCGCATCATT	0.498000											OREG0015847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	145	28					0	0	0.003610	0	0
ZNF683	257101	broad.mit.edu	37	1	26691127	26691127	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:26691127T>C	ENST00000436292.1	-	4	1030	c.910A>G	c.(910-912)Aca>Gca	p.T304A	ZNF683_ENST00000349618.3_Missense_Mutation_p.T304A|ZNF683_ENST00000403843.1_Missense_Mutation_p.T304A|ZNF683_ENST00000374204.1_Missense_Mutation_p.T304A			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GCGGTGCCTGTCTGGGAACTC	0.577000													3	130					0	0	0.004672	0	0
GPR112	139378	broad.mit.edu	37	X	135404984	135404984	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chrX:135404984G>C	ENST00000394143.1	+	5	409	c.118G>C	c.(118-120)Gac>Cac	p.D40H	GPR112_ENST00000412101.1_Intron|GPR112_ENST00000287534.4_5'UTR|GPR112_ENST00000370652.1_Missense_Mutation_p.D40H|GPR112_ENST00000394141.1_Intron	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	40					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGGAAGAGGTGACACATATGT	0.388000													38	9					0	0	0.004289	0	0
ITPR2	3709	broad.mit.edu	37	12	26781079	26781079	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:26781079C>T	ENST00000381340.3	-	23	3367	c.2951G>A	c.(2950-2952)aGa>aAa	p.R984K	RP11-666F17.1_ENST00000414098.2_RNA|ITPR2_ENST00000545902.1_5'UTR	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	984					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	p.R984K(1)	ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					ATAATCCAGTCTGACACTCAG	0.353000													61	119					0	0	0.003610	0	0
PLCB4	5332	broad.mit.edu	37	20	9353027	9353027	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:9353027T>A	ENST00000378501.2	+	8	678	c.663T>A	c.(661-663)gaT>gaA	p.D221E	PLCB4_ENST00000378493.1_Missense_Mutation_p.D221E|PLCB4_ENST00000378473.3_Missense_Mutation_p.D221E|PLCB4_ENST00000334005.3_Missense_Mutation_p.D221E|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.D221E|PLCB4_ENST00000414679.2_Missense_Mutation_p.D221E	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	221					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CTCGGACAGATATAGAAGATC	0.308000													14	36					0	0	0.002450	0	0
SALL1	6299	broad.mit.edu	37	16	51171062	51171062	+	Silent	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:51171062G>C	ENST00000440970.1	-	3	4076	c.3645C>G	c.(3643-3645)acC>acG	p.T1215T	SALL1_ENST00000541611.1_Silent_p.T135T|SALL1_ENST00000251020.4_Silent_p.T1312T|SALL1_ENST00000566102.1_3'UTR	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1312					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCACGAAGCGGGTGAAGCGGA	0.567000													23	33					0	0	0.001882	0	0
NCAM2	4685	broad.mit.edu	37	21	22849748	22849748	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr21:22849748C>G	ENST00000400546.1	+	15	2282	c.2033C>G	c.(2032-2034)aCa>aGa	p.T678R	NCAM2_ENST00000284894.7_Missense_Mutation_p.T536R	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	678	Fibronectin type-III 2.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TCTGAACCGACAGTTTATGAA	0.368000													16	14					0	0	0.007413	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304740	102304740	+	RNA	SNP	G	G	C	rs7169420	by1000genomes	TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr15:102304740G>C	ENST00000561463.1	+	0	12786																											GAAGACACTCGTGGAGGAGTC	0.612000													5	21					0	0	0.001168	0	0
QTRT1	81890	broad.mit.edu	37	19	10823850	10823850	+	Silent	SNP	C	C	T	rs139740339	byFrequency	TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:10823850C>T	ENST00000250237.5	+	10	1126	c.1116C>T	c.(1114-1116)ttC>ttT	p.F372F		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	372					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			TCCCGGACTTCGTGCGGGACT	0.657000													38	48					0	0	0.006230	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48916922	48916922	+	Silent	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:48916922C>A	ENST00000311378.4	+	2	801	c.273C>A	c.(271-273)gcC>gcA	p.A91A	WFIKKN2_ENST00000426127.1_5'UTR	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	91	WAP.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCGTGGCGGCCCGCTACATGG	0.582000													14	21					1.49906e-05	7.88749e-05	0.002450	1	0
ZNF675	171392	broad.mit.edu	37	19	23837318	23837318	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:23837318C>A	ENST00000359788.4	-	4	585	c.417G>T	c.(415-417)atG>atT	p.M139I	ZNF675_ENST00000601935.1_Intron|ZNF675_ENST00000600313.1_Intron|ZNF675_ENST00000596211.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	139					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTTTGCTCTGCATAGTTGGTA	0.299000													28	31					6.32553e-13	3.49061e-12	0.004656	1	0
BHLHA15	168620	broad.mit.edu	37	7	97841820	97841820	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:97841820G>A	ENST00000314018.2	+	1	255	c.199G>A	c.(199-201)Ggt>Agt	p.G67S		NM_177455.3	NP_803238.1	Q7RTS1	BHA15_HUMAN	basic helix-loop-helix family, member a15	67					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding										CTCCGGGCCCGGTGGCCGTCG	0.736000													6	10					0	0	0.001168	0	0
BCL10	8915	broad.mit.edu	37	1	85733454	85733454	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:85733454G>A	ENST00000370580.1	-	3	1295	c.558C>T	c.(556-558)atC>atT	p.I186I		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	186					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		TTGAAGAGAAGATGGTATTTT	0.458000			T	IGH@	MALT								19	10					0	0	0.006122	0	0
GNPAT	8443	broad.mit.edu	37	1	231406686	231406686	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:231406686A>G	ENST00000366647.4	+	10	1631	c.1462A>G	c.(1462-1464)Att>Gtt	p.I488V	GNPAT_ENST00000366646.3_Missense_Mutation_p.I427V	NM_014236.3	NP_055051.1	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	488					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	23	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				GCTGCTCAACATTTTTGTGCG	0.478000													68	92					0	0	0.003610	0	0
TMEM2	23670	broad.mit.edu	37	9	74332991	74332991	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:74332991G>A	ENST00000377044.4	-	13	2811	c.2272C>T	c.(2272-2274)Cga>Tga	p.R758*	TMEM2_ENST00000377066.5_Nonsense_Mutation_p.R695*	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	758						integral to membrane		p.R758*(1)		central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGATGAGGTCGAAATCTAGGG	0.338000													27	37					0	0	0.001786	0	0
ZNF394	84124	broad.mit.edu	37	7	99097557	99097557	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:99097557G>T	ENST00000337673.6	-	1	363	c.160C>A	c.(160-162)Ccc>Acc	p.P54T	ZNF394_ENST00000394177.3_Intron|ZNF394_ENST00000426306.2_Missense_Mutation_p.P54T|ZNF789_ENST00000493485.1_Intron|ZNF789_ENST00000494186.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	54					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GAAGCCGCGGGATAGTTGGGC	0.642000													43	50					1.15183e-24	6.59752e-24	0.002222	1	0
ECE2	9718	broad.mit.edu	37	3	183995809	183995809	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:183995809C>A	ENST00000402825.3	+	5	929	c.929C>A	c.(928-930)gCc>gAc	p.A310D	ECE2_ENST00000357474.5_Missense_Mutation_p.A238D|ECE2_ENST00000359140.4_Missense_Mutation_p.A163D|ECE2_ENST00000404464.3_Missense_Mutation_p.A192D|EIF2B5_ENST00000444495.1_Intron	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	310	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAGCTGGGAGCCCAGCCACTG	0.577000													120	13					1.37143e-49	8.16545e-49	0.003610	1	0
GRM2	2912	broad.mit.edu	37	3	51743449	51743449	+	Splice_Site	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:51743449G>A	ENST00000395052.3	+	2	684	c.450_splice	c.e2+1	p.Q150_splice	GRM2_ENST00000442933.2_Splice_Site_p.Q150_splice|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	150					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TCTCCATCCAGGTACGTGGAA	0.582000													6	4					0	0	0.001168	0	0
MANEAL	149175	broad.mit.edu	37	1	38265848	38265848	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:38265848C>G	ENST00000373045.6	+	4	1728	c.1347C>G	c.(1345-1347)atC>atG	p.I449M	RP11-109P14.9_ENST00000433474.1_RNA|MANEAL_ENST00000525897.1_Missense_Mutation_p.I255M|MANEAL_ENST00000329006.5_Missense_Mutation_p.I227M|MANEAL_ENST00000397631.3_3'UTR	NM_001113482.1	NP_001106954.1	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like	449						Golgi membrane|integral to membrane	hydrolase activity			endometrium(1)|large_intestine(1)|liver(1)|lung(1)|prostate(3)	7	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGCACTTCATCAAAGAGAAGG	0.582000													44	18					0	0	0.003214	0	0
SACS	26278	broad.mit.edu	37	13	23905802	23905802	+	Silent	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:23905802T>C	ENST00000382298.3	-	10	12801	c.12213A>G	c.(12211-12213)gaA>gaG	p.E4071E	SACS_ENST00000402364.1_Silent_p.E3321E|SACS_ENST00000382292.3_Silent_p.E4071E	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4071					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGCAAAAGTTTCACTTCTGC	0.363000													19	33					0	0	0.001216	0	0
NINL	22981	broad.mit.edu	37	20	25485703	25485703	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:25485703T>C	ENST00000278886.6	-	6	602	c.529A>G	c.(529-531)Acc>Gcc	p.T177A	NINL_ENST00000422516.1_Missense_Mutation_p.T177A	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	177					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GAATCCCAGGTCTGCAGCTGT	0.572000													4	9					0	0	0.000248	0	0
FRY	10129	broad.mit.edu	37	13	32798394	32798394	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:32798394G>A	ENST00000380250.3	+	37	5284	c.4788G>A	c.(4786-4788)acG>acA	p.T1596T		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTCCCTACACGGGCTGGTTGC	0.498000													42	48					0	0	0.003610	0	0
NIN	51199	broad.mit.edu	37	14	51227017	51227017	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr14:51227017T>A	ENST00000245441.5	-	17	2147	c.1957A>T	c.(1957-1959)Aac>Tac	p.N653Y	NIN_ENST00000389868.3_Missense_Mutation_p.N653Y|NIN_ENST00000382041.3_Missense_Mutation_p.N653Y|NIN_ENST00000382043.4_Missense_Mutation_p.N653Y|NIN_ENST00000324330.9_Missense_Mutation_p.N653Y|NIN_ENST00000530997.2_Missense_Mutation_p.N653Y|NIN_ENST00000453196.1_Missense_Mutation_p.N653Y	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	653					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCTTCATGTTCTCCTGTGCC	0.468000			T	PDGFRB	MPD								82	25					0	0	0.003610	0	0
DDX21	9188	broad.mit.edu	37	10	70728814	70728814	+	Silent	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:70728814A>G	ENST00000354185.4	+	7	1271	c.1173A>G	c.(1171-1173)aaA>aaG	p.K391K		NM_001256910.1|NM_004728.3	NP_001243839.1|NP_004719.2	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 21	391	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	20						AATACATGAAATCTACATATG	0.363000													34	48					0	0	0.002096	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47243530	47243530	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:47243530C>T	ENST00000300404.2	+	9	1248	c.1189C>T	c.(1189-1191)Ctc>Ttc	p.L397F	B4GALNT2_ENST00000393354.2_Missense_Mutation_p.L337F|B4GALNT2_ENST00000504681.1_Missense_Mutation_p.L311F	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	397					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CAAATACGTTCTCTGGGTGGA	0.473000													27	51					0	0	0.007291	0	0
MALAT1	378938	broad.mit.edu	37	11	65272655	65272655	+	RNA	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:65272655C>T	ENST00000534336.1	+	0	7423					NR_002819.2																						TAAGATTTTTCAGGTACCCCT	0.493000													20	54					0	0	0.001523	0	0
NEB	4703	broad.mit.edu	37	2	152534129	152534129	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:152534129C>A	ENST00000397345.3	-	34	3926	c.3724G>T	c.(3724-3726)Gac>Tac	p.D1242Y	NEB_ENST00000409198.1_Missense_Mutation_p.D1242Y|NEB_ENST00000603639.1_Missense_Mutation_p.D1242Y|NEB_ENST00000172853.10_Missense_Mutation_p.D1242Y|NEB_ENST00000604864.1_Missense_Mutation_p.D1242Y|NEB_ENST00000427231.2_Missense_Mutation_p.D1242Y	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	1242					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACTGGGGAGTCCACAATGCTG	0.443000													35	74					3.90053e-15	2.179e-14	0.002445	1	0
B4GALNT1	2583	broad.mit.edu	37	12	58021951	58021951	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:58021951C>T	ENST00000341156.4	-	9	1681	c.1097G>A	c.(1096-1098)cGg>cAg	p.R366Q	B4GALNT1_ENST00000418555.2_Missense_Mutation_p.R311Q	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	366					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CCTCTCCAGCCGCGTCCGCGC	0.652000													24	39					0	0	0.006320	0	0
KMT2D	8085	broad.mit.edu	37	12	49420108	49420108	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:49420108C>T	ENST00000301067.7	-	48	15640	c.15641G>A	c.(15640-15642)cGc>cAc	p.R5214H		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCAATAGATGCGCGTGGCCTC	0.577000													23	30					0	0	0.001882	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72038823	72038823	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:72038823T>A	ENST00000378743.3	-	4	1471	c.1113A>T	c.(1111-1113)gaA>gaT	p.E371D		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	371					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GAAGCTGTAATTCAGATAGTT	0.338000													16	22					0	0	0.003163	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6438514	6438514	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:6438514G>A	ENST00000162749.2	-	10	1631	c.1332C>T	c.(1330-1332)ccC>ccT	p.P444P	TNFRSF1A_ENST00000540022.1_Silent_p.P401P	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	444				GPAA -> APP (in Ref. 5; AAA36756).	apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						ggagggcggcggggccgcAAA	0.706000													6	18					0	0	0.001168	0	0
ZNF677	342926	broad.mit.edu	37	19	53740901	53740901	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:53740901G>A	ENST00000333952.4	-	5	1244	c.1079C>T	c.(1078-1080)tCa>tTa	p.S360L	ZNF677_ENST00000598513.1_Missense_Mutation_p.S360L			Q86XU0	ZN677_HUMAN	zinc finger protein 677	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		CCAAAGGTGTGAACGCTGGAT	0.393000													38	13					0	0	0.004289	0	0
LAMB4	22798	broad.mit.edu	37	7	107696109	107696109	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:107696109G>C	ENST00000388781.3	-	25	3806	c.3723C>G	c.(3721-3723)ttC>ttG	p.F1241L	LAMB4_ENST00000388780.3_Missense_Mutation_p.F1241L|LAMB4_ENST00000205386.4_Missense_Mutation_p.F1241L	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1241	Domain II.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TGACTTTTAAGAATTTCCCAG	0.413000													49	101					0	0	0.003610	0	0
NOX4	50507	broad.mit.edu	37	11	89070672	89070672	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:89070672C>T	ENST00000535633.1	-	16	1696	c.1386G>A	c.(1384-1386)gaG>gaA	p.E462E	NOX4_ENST00000542487.1_Silent_p.E462E|NOX4_ENST00000413594.2_Silent_p.E507E|NOX4_ENST00000527626.1_Silent_p.E299E|NOX4_ENST00000532825.1_Silent_p.E422E|NOX4_ENST00000527956.1_Silent_p.E462E|NOX4_ENST00000534731.1_Silent_p.E446E|NOX4_ENST00000424319.1_Silent_p.E462E|NOX4_ENST00000528341.1_Silent_p.E461E|NOX4_ENST00000343727.5_Silent_p.E462E|NOX4_ENST00000525196.1_Silent_p.E250E|NOX4_ENST00000531342.1_Silent_p.E139E|NOX4_ENST00000375979.3_Silent_p.E179E|NOX4_ENST00000263317.4_Silent_p.E486E	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	486	Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CAGGTCTGTTCTCTTGCCAAA	0.368000													5	22					0	0	0.000602	0	0
CABS1	85438	broad.mit.edu	37	4	71201610	71201610	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:71201610T>C	ENST00000273936.4	+	1	913	c.854T>C	c.(853-855)cTg>cCg	p.L285P		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	285						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GAAGATACTCTGCTAACTGAT	0.418000													19	12					0	0	0.006122	0	0
UBE4A	9354	broad.mit.edu	37	11	118263519	118263519	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:118263519C>T	ENST00000252108.3	+	19	3114	c.2983C>T	c.(2983-2985)Ccc>Tcc	p.P995S	UBE4A_ENST00000431736.2_Missense_Mutation_p.P1002S|UBE4A_ENST00000545354.1_Missense_Mutation_p.P467S	NM_001204077.1|NM_004788.3	NP_001191006.1|NP_004779.2	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	995	U-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(7)|liver(2)|lung(14)|ovary(3)|prostate(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	56	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GTTCCTGGATCCCATTATGAG	0.473000													131	26					0	0	0.003610	0	0
GRK5	2869	broad.mit.edu	37	10	121207759	121207759	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:121207759C>T	ENST00000392870.2	+	13	1720	c.1391C>T	c.(1390-1392)cCc>cTc	p.P464L	GRK5_ENST00000369108.3_Missense_Mutation_p.P359L	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	464	AGC-kinase C-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		TTGGACCCTCCCTTCGTTCCA	0.627000													70	100					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179443989	179443989	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179443989G>T	ENST00000589042.1	-	320	67992	c.67768C>A	c.(67768-67770)Cct>Act	p.P22590T	TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P13650T|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P13717T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|RP11-171I2.2_ENST00000603521.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P13525T|TTN_ENST00000591111.1_Missense_Mutation_p.P20949T|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P20022T|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20949	Fibronectin type-III 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGCTAGAGGATCTTCCCCT	0.433000													39	63					1.58521e-26	9.13765e-26	0.005524	1	0
EXPH5	23086	broad.mit.edu	37	11	108380450	108380450	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:108380450G>A	ENST00000265843.4	-	6	5894	c.5784C>T	c.(5782-5784)aaC>aaT	p.N1928N	EXPH5_ENST00000443411.1_Silent_p.N1740N|EXPH5_ENST00000525344.1_Silent_p.N1921N|EXPH5_ENST00000428840.1_Silent_p.N1852N	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1928					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GGTTGGGAGGGTTCCTCAAAT	0.413000													50	13					0	0	0.003610	0	0
MYH4	4622	broad.mit.edu	37	17	10364246	10364246	+	Silent	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:10364246T>A	ENST00000255381.2	-	12	1244	c.1134A>T	c.(1132-1134)ccA>ccT	p.P378P	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	378	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CCGTGCCATCTGGCTCTGCCT	0.478000													30	69					0	0	0.002096	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891658	2891658	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:2891658C>A	ENST00000254528.3	+	4	1692	c.1533C>A	c.(1531-1533)aaC>aaA	p.N511K		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	511					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		TGACCAATAACACTGGTGCAG	0.527000													36	52					2.04263e-09	1.1136e-08	0.004289	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971098	21971098	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:21971098C>G	ENST00000304494.5	-	2	530	c.260G>C	c.(259-261)cGg>cCg	p.R87P	CDKN2A_ENST00000479692.2_Missense_Mutation_p.R36P|CDKN2A_ENST00000494262.1_Missense_Mutation_p.R36P|CDKN2A_ENST00000578845.2_Missense_Mutation_p.R36P|CDKN2A_ENST00000579755.1_Silent_p.P101P|CDKN2A_ENST00000498124.1_Missense_Mutation_p.R87P|CDKN2A_ENST00000446177.1_Missense_Mutation_p.R87P|CDKN2A_ENST00000530628.2_Silent_p.P101P|CDKN2A_ENST00000579122.1_Missense_Mutation_p.R87P|CDKN2A_ENST00000497750.1_Missense_Mutation_p.R36P|CDKN2A_ENST00000498628.2_Missense_Mutation_p.R36P|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000361570.3_Silent_p.P142P	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	87			R -> P (in CMM2; impairs the function).|R -> W (in CMM2; partial loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.H83fs*2(2)|p.D84_F90del(1)|p.0(1)|p.V82_G89>G(1)|p.R87L(1)|p.E61_L94del(1)|p.R87Q(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.V82_E88del(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GAAGCCCTCCCGGGCAGCGTC	0.751000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	3					0	0	0.003080	0	0
MYO3A	53904	broad.mit.edu	37	10	26377179	26377179	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:26377179G>T	ENST00000265944.5	+	15	1573	c.1407G>T	c.(1405-1407)ttG>ttT	p.L469F	MYO3A_ENST00000543632.1_Missense_Mutation_p.L469F	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	469	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TGAACAATTTGGTAGAAGCCT	0.303000													15	21					3.45872e-05	0.000178865	0.004007	1	0
LRP6	4040	broad.mit.edu	37	12	12278294	12278294	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:12278294C>G	ENST00000261349.4	-	21	4461	c.4385G>C	c.(4384-4386)cGa>cCa	p.R1462P	LRP6_ENST00000543091.1_Missense_Mutation_p.R1417P|BCL2L14_ENST00000396369.1_Intron	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1462					cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				AACATGGGCTCGGTCATAGGG	0.443000													18	22					0	0	0.006122	0	0
DDX55	57696	broad.mit.edu	37	12	124104018	124104018	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:124104018T>C	ENST00000238146.4	+	13	1423	c.1373T>C	c.(1372-1374)cTg>cCg	p.L458P	DDX55_ENST00000541259.1_3'UTR|DDX55_ENST00000538744.1_Missense_Mutation_p.L427P|DDX55_ENST00000421670.3_Missense_Mutation_p.L65P	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	458							ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TTTGCCCTGCTGAGGATGCCC	0.438000													49	79					0	0	0.003610	0	0
USP22	23326	broad.mit.edu	37	17	20911270	20911270	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:20911270G>C	ENST00000261497.4	-	9	1346	c.1143C>G	c.(1141-1143)atC>atG	p.I381M	USP22_ENST00000537526.2_Missense_Mutation_p.I369M|USP22_ENST00000455117.2_Intron	NM_015276.1	NP_056091.1	Q9UPT9	UBP22_HUMAN	ubiquitin specific peptidase 22	381					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	15						CGCTGCACTTGATCTTGGCGC	0.488000													33	33					0	0	0.002445	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659293	50659293	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr22:50659293G>A	ENST00000439308.2	-	16	3987	c.3495C>T	c.(3493-3495)tcC>tcT	p.S1165S	TUBGCP6_ENST00000248846.5_Silent_p.S1165S|TUBGCP6_ENST00000491449.1_5'UTR	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1165	9 X 27 AA tandem repeats.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding	p.S1165S(2)		breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGCTGGCATCGGACACGTGTC	0.637000													21	76					0	0	0.001523	0	0
VPS13A	23230	broad.mit.edu	37	9	79853254	79853254	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:79853254G>T	ENST00000360280.3	+	19	2112	c.1852G>T	c.(1852-1854)Gca>Tca	p.A618S	VPS13A_ENST00000376634.4_Missense_Mutation_p.A618S|VPS13A_ENST00000376636.3_Missense_Mutation_p.A618S|VPS13A_ENST00000357409.5_Missense_Mutation_p.A618S	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	618					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ACAGCTCACTGCAGCAACTTT	0.348000													29	39					3.48256e-35	2.03337e-34	0.005524	1	0
ROS1	6098	broad.mit.edu	37	6	117658469	117658469	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:117658469G>A	ENST00000368508.3	-	31	5312	c.5114C>T	c.(5113-5115)tCa>tTa	p.S1705L	ROS1_ENST00000368507.3_Missense_Mutation_p.S1699L|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1705	Fibronectin type-III 8.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTGGCTGCATGAAGTTTTAAC	0.308000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								30	35					0	0	0.001512	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582515	136582515	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:136582515C>A	ENST00000531224.1	-	12	2897	c.2645G>T	c.(2644-2646)gGt>gTt	p.G882V	BCLAF1_ENST00000392348.2_Missense_Mutation_p.G831V|BCLAF1_ENST00000527536.1_Missense_Mutation_p.G833V|BCLAF1_ENST00000527759.1_Missense_Mutation_p.G880V|BCLAF1_ENST00000031135.9_Missense_Mutation_p.G100V|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000530767.1_Missense_Mutation_p.G709V|BCLAF1_ENST00000353331.4_Missense_Mutation_p.G831V	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	882					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGGACTGCTACCTGATTTTTT	0.438000													55	245					3.4597e-24	1.9692e-23	0.003610	1	0
SALL1	6299	broad.mit.edu	37	16	51174418	51174418	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:51174418G>A	ENST00000440970.1	-	2	1855	c.1424C>T	c.(1423-1425)aCg>aTg	p.T475M	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.T572M|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	572					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCTCTTCCGTCTTGATGAA	0.602000													17	31					0	0	0.004990	0	0
MEX3D	399664	broad.mit.edu	37	19	1556345	1556345	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:1556345G>A	ENST00000402693.4	-	2	1172	c.1173C>T	c.(1171-1173)cgC>cgT	p.R391R	MEX3D_ENST00000388824.6_Silent_p.R391R	NM_203304.3	NP_976049.3	Q86XN8	MEX3D_HUMAN	mex-3 RNA binding family member D	391					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			endometrium(1)|lung(3)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGTCCCCGCGGAGGCCGG	0.801000													8	7					0	0	0.004482	0	0
SLC19A2	10560	broad.mit.edu	37	1	169446399	169446399	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:169446399C>A	ENST00000236137.5	-	2	1037	c.801G>T	c.(799-801)gaG>gaT	p.E267D	SLC19A2_ENST00000367802.3_Intron|SLC19A2_ENST00000367804.3_Intron	NM_006996.2	NP_008927.1	O60779	S19A2_HUMAN	solute carrier family 19 (thiamine transporter), member 2	267					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.208)					TTACCGGTTCCTCCACGGGAG	0.478000													56	79					5.73376e-24	3.24316e-23	0.003610	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110457673	110457673	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:110457673G>T	ENST00000378402.5	+	38	5679	c.5575G>T	c.(5575-5577)Ggc>Tgc	p.G1859C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1859	IPT/TIG 11.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTTCTATCCAGGCAACACTAC	0.502000										HNSCC(38;0.096)			39	7					6.97489e-18	3.92067e-17	0.004878	1	0
TP53	7157	broad.mit.edu	37	17	7578524	7578524	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:7578524G>A	ENST00000420246.2	-	5	538	c.406C>T	c.(406-408)Caa>Taa	p.Q136*	TP53_ENST00000359597.4_Nonsense_Mutation_p.Q136*|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q136*|TP53_ENST00000413465.2_Nonsense_Mutation_p.Q136*|TP53_ENST00000445888.2_Nonsense_Mutation_p.Q136*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q136*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	136	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> E (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(34)|p.0?(8)|p.C135fs*9(3)|p.Q136E(3)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.Q136K(1)|p.S127_Q136del10(1)|p.V73fs*9(1)|p.Q43*(1)|p.Y126fs*11(1)|p.Q4*(1)|p.C3fs*9(1)|p.C42fs*9(1)|p.C135_A138delCQLA(1)|p.Q136_K139delQLAK(1)|p.Q136fs*34(1)|p.C135_T140delCQLAKT(1)|p.Q136fs*13(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCCAGTTGGCAAAACATC	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			64	7					0	0	0.003610	0	0
NAA20	51126	broad.mit.edu	37	20	20013295	20013295	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:20013295A>G	ENST00000398602.2	+	5	1048	c.413A>G	c.(412-414)tAt>tGt	p.Y138C	NAA20_ENST00000484480.1_3'UTR|NAA20_ENST00000310450.4_Intron|NAA20_ENST00000334982.4_Missense_Mutation_p.Y150C	NM_181527.3	NP_852668.1	P61599	NAA20_HUMAN	N(alpha)-acetyltransferase 20, NatB catalytic subunit	150	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity			endometrium(3)|lung(2)|prostate(1)	6						GAGGACGCTTATGGTAAGCTC	0.408000													25	31					0	0	0.003954	0	0
GART	2618	broad.mit.edu	37	21	34877966	34877966	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr21:34877966C>G	ENST00000381831.3	-	20	2890	c.2627G>C	c.(2626-2628)aGt>aCt	p.S876T	GART_ENST00000543717.1_Missense_Mutation_p.S428T|GART_ENST00000381815.4_Missense_Mutation_p.S876T|GART_ENST00000381839.3_Missense_Mutation_p.S876T	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	876	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	GTCAATTGCACTGTCAAATTC	0.338000													22	6					0	0	0.001523	0	0
OR4C15	81309	broad.mit.edu	37	11	55322553	55322553	+	Silent	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:55322553G>T	ENST00000314644.2	+	1	771	c.771G>T	c.(769-771)ggG>ggT	p.G257G		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TCAACAGTGGGTTTATCTGCA	0.463000										HNSCC(20;0.049)			15	22					3.27435e-08	1.77442e-07	0.002450	1	0
ZNF559	84527	broad.mit.edu	37	19	9452988	9452988	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:9452988T>G	ENST00000393883.2	+	6	1509	c.861T>G	c.(859-861)caT>caG	p.H287Q	ZNF559_ENST00000587557.1_Missense_Mutation_p.H351Q|ZNF177_ENST00000541595.2_Intron|ZNF559_ENST00000538743.1_Missense_Mutation_p.H207Q|ZNF559_ENST00000317221.7_3'UTR|ZNF177_ENST00000605471.1_Intron|ZNF177_ENST00000446085.4_Intron|ZNF559_ENST00000586255.1_Intron|ZNF177_ENST00000602856.1_Intron|ZNF559_ENST00000592896.1_3'UTR|ZNF177_ENST00000602738.1_Intron|ZNF559_ENST00000603380.1_Missense_Mutation_p.H287Q	NM_001202412.1	NP_001189341.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						TTGCTAAACATATAAGACTTA	0.333000													37	62					0	0	0.001951	0	0
STEAP4	79689	broad.mit.edu	37	7	87910251	87910251	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:87910251C>T	ENST00000380079.4	-	4	1229	c.1128G>A	c.(1126-1128)tgG>tgA	p.W376*	AC003991.3_ENST00000600908.1_RNA|AC003991.3_ENST00000595121.1_RNA|AC003991.3_ENST00000447758.1_RNA|STEAP4_ENST00000301959.5_Nonsense_Mutation_p.W200*|AC003991.3_ENST00000434733.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	376	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					GGAACTCTCTCCAGTTGACTG	0.378000													45	110					0	0	0.003610	0	0
ATAD2B	54454	broad.mit.edu	37	2	24056881	24056881	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:24056881C>G	ENST00000238789.5	-	14	1979	c.1636G>C	c.(1636-1638)Ggt>Cgt	p.G546R		NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	546							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGTAGCACCAATAACAACA	0.383000													13	24					0	0	0.001855	0	0
TUSC3	7991	broad.mit.edu	37	8	15601046	15601046	+	Splice_Site	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:15601046G>T	ENST00000382020.4	+	8	1070		c.e8-1		TUSC3_ENST00000506802.1_Splice_Site|TUSC3_ENST00000503731.1_Splice_Site	NM_178234.2	NP_839952.1	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3						cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(10)|ovary(2)	28				Colorectal(111;0.113)		AACTACTGCAGATGCCGCTAT	0.403000													23	137					5.35356e-11	2.93635e-10	0.002780	1	0
SLC9A2	6549	broad.mit.edu	37	2	103274384	103274384	+	Silent	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:103274384C>A	ENST00000233969.2	+	2	793	c.651C>A	c.(649-651)gtC>gtA	p.V217V		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	217						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						TCTCAGCTGTCGATCCTGTGG	0.498000													108	148					3.11409e-38	1.84199e-37	0.003610	1	0
ZC3H4	23211	broad.mit.edu	37	19	47584783	47584783	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:47584783T>A	ENST00000253048.5	-	11	1464	c.1427A>T	c.(1426-1428)gAg>gTg	p.E476V	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	476							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		ATCCAAGAGCTCCCTCGTCTC	0.577000													22	12					0	0	0.001882	0	0
MSH4	4438	broad.mit.edu	37	1	76276476	76276476	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:76276476T>C	ENST00000263187.3	+	4	787	c.683T>C	c.(682-684)aTc>aCc	p.I228T		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	228					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TTCACTCTGATCACAGAAAAT	0.274000								Mismatch excision repair (MMR)					27	11					0	0	0.007291	0	0
SAMD3	154075	broad.mit.edu	37	6	130505272	130505272	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:130505272G>A	ENST00000532763.1	-	6	753	c.624C>T	c.(622-624)ttC>ttT	p.F208F	SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000368134.2_Silent_p.F210F|SAMD3_ENST00000437477.2_Silent_p.F210F|SAMD3_ENST00000324172.6_Silent_p.F210F|SAMD3_ENST00000457563.2_Silent_p.F234F|SAMD3_ENST00000439090.2_Silent_p.F210F			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	210										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CCTCATCCAGGAAAGGGTGGG	0.468000													26	34					0	0	0.006320	0	0
ENO1	2023	broad.mit.edu	37	1	8926383	8926385	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:8926383_8926385delCCA	ENST00000234590.4	-	7	739_741	c.620_622delTGG	c.(619-624)ggg>g	p.VG207del		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	207	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CCTTCATCCCCCACATTGGTGGC	0.552													52	29	---	---	---	---					
ZBTB18	10472	broad.mit.edu	37	1	244217124	244217125	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:244217124_244217125insA	ENST00000358704.4	+	2	197_198	c.48_49insA	c.(46-51)aggacafs	p.T17fs		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		CAGACCATAGTAGACATTTGCT	0.510													27	38	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184039744	184039746	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:184039744_184039746delGAA	ENST00000342981.4	+	9	1786_1788	c.1372_1374delGAA	c.(1372-1374)del	p.E465del	EIF4G1_ENST00000352767.3_In_Frame_Del_p.E472del|EIF4G1_ENST00000414031.1_In_Frame_Del_p.E425del|EIF4G1_ENST00000434061.2_In_Frame_Del_p.E269del|EIF4G1_ENST00000392537.2_In_Frame_Del_p.E378del|EIF4G1_ENST00000350481.5_In_Frame_Del_p.E301del|EIF4G1_ENST00000382330.3_In_Frame_Del_p.E472del|EIF4G1_ENST00000411531.1_In_Frame_Del_p.E425del|EIF4G1_ENST00000346169.2_In_Frame_Del_p.E465del|EIF4G1_ENST00000427845.1_In_Frame_Del_p.E378del|EIF4G1_ENST00000441154.1_In_Frame_Del_p.E301del|EIF4G1_ENST00000435046.2_In_Frame_Del_p.E269del|EIF4G1_ENST00000319274.6_In_Frame_Del_p.E465del|EIF4G1_ENST00000424196.1_In_Frame_Del_p.E472del|EIF2B5_ENST00000444495.1_Intron	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	465	Poly-Glu.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGGAAATGgaagaagaagaag	0.562													7	190	---	---	---	---					
USP38	84640	broad.mit.edu	37	4	144106780	144106780	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:144106780delG	ENST00000307017.4	+	1	683	c.177delG	c.(175-177)cafs	p.Q59fs	USP38_ENST00000510377.1_Frame_Shift_Del_p.Q59fs	NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	59					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					TCCAGCGGCAGGTGGGGCACC	0.627													17	9	---	---	---	---					
HIST1H2BG	8339	broad.mit.edu	37	6	26216820	26216831	+	In_Frame_Del	DEL	CCTTCTTGGAAC	CCTTCTTGGAAC	-	rs143774290		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:26216820_26216831delCCTTCTTGGAAC	ENST00000244601.3	-	1	41_52	c.41_52delGTTCCAAGAAGG	c.(40-54)gct>g	p.GSKKA14del		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	14					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding	p.K17E(1)		endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				TTGGTCACAGCCTTCTTGGAACCCTTCTTCGG	0.491													32	48	---	---	---	---					
MAP3K12	7786	broad.mit.edu	37	12	53875912	53875913	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:53875912_53875913insT	ENST00000267079.2	-	14	2518_2519	c.2293_2294insA	c.(2293-2295)tgafs	p.*765fs	MAP3K12_ENST00000547035.1_Frame_Shift_Ins_p.*798fs|MAP3K12_ENST00000547488.1_Frame_Shift_Ins_p.*798fs	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	765					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						GGAAGGTTCACTAGCTGTGCCT	0.554											OREG0021873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	93	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78400648	78400648	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:78400648delC	ENST00000397909.2	+	8	1503	c.1330delC	c.(1330-1332)ctfs	p.P444fs	NAV3_ENST00000266692.7_Frame_Shift_Del_p.P444fs|NAV3_ENST00000228327.6_Frame_Shift_Del_p.P444fs|NAV3_ENST00000536525.2_Frame_Shift_Del_p.P444fs			Q8IVL0	NAV3_HUMAN	neuron navigator 3	444						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CAAAGTGTCACCTAAGTTGGC	0.408										HNSCC(70;0.22)			34	68	---	---	---	---					
AJUBA	84962	broad.mit.edu	37	14	23451332	23451332	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr14:23451332delC	ENST00000262713.2	-	1	519	c.144delG	c.(142-144)ggfs	p.G48fs	RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000361265.4_Frame_Shift_Del_p.G48fs	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	48	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										CTCCTCGGGGCCCTGACTTCC	0.682													115	12	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													2	4	---	---	---	---					
MBD1	4152	broad.mit.edu	37	18	47800213	47800214	+	Frame_Shift_Ins	INS	-	-	AC			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:47800213_47800214insAC	ENST00000591416.1	-	12	1597_1598	c.1166_1167insGT	c.(1165-1167)gtgfs	p.V389fs	MBD1_ENST00000591535.1_Frame_Shift_Ins_p.V366fs|MBD1_ENST00000339998.6_Frame_Shift_Ins_p.V389fs|MBD1_ENST00000590208.1_Frame_Shift_Ins_p.V389fs|MBD1_ENST00000588937.1_Frame_Shift_Ins_p.V366fs|MBD1_ENST00000587605.1_Frame_Shift_Ins_p.V333fs|MBD1_ENST00000269468.5_Frame_Shift_Ins_p.V389fs|MBD1_ENST00000398488.1_Frame_Shift_Ins_p.V333fs|MBD1_ENST00000398493.1_Frame_Shift_Ins_p.V333fs|MBD1_ENST00000398495.2_Frame_Shift_Ins_p.V358fs|MBD1_ENST00000382948.5_Frame_Shift_Ins_p.V389fs|MBD1_ENST00000353909.3_Frame_Shift_Ins_p.V340fs|MBD1_ENST00000269471.5_Frame_Shift_Ins_p.V366fs|MBD1_ENST00000349085.2_Frame_Shift_Ins_p.V333fs|MBD1_ENST00000347968.3_Frame_Shift_Ins_p.V333fs|MBD1_ENST00000585672.1_Frame_Shift_Ins_p.V339fs|MBD1_ENST00000585595.1_Frame_Shift_Ins_p.V414fs|MBD1_ENST00000457839.2_Frame_Shift_Ins_p.V414fs|MBD1_ENST00000436910.1_Frame_Shift_Ins_p.V366fs|MBD1_ENST00000424334.2_Frame_Shift_Ins_p.V440fs			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	389					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						ACTCTGACCAGACACTGGGCAG	0.609													43	89	---	---	---	---					
ZNF208	7757	broad.mit.edu	37	19	22154308	22154308	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:22154308delT	ENST00000397126.4	-	4	3676	c.3528delA	c.(3526-3528)aafs	p.K1176fs	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAACAAAGCCTTTGCCACATT	0.383													10	66	---	---	---	---					
PPP1R3D	5509	broad.mit.edu	37	20	58514574	58514577	+	Frame_Shift_Del	DEL	TTGA	TTGA	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:58514574_58514577delTTGA	ENST00000370996.3	-	1	775_778	c.410_413delTCAA	c.(409-414)acfs	p.IN137fs	FAM217B_ENST00000358293.3_Intron	NM_006242.3	NP_006233.1	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	137					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|urinary_tract(1)	13	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CAGGTCCGAGTTGATTGCGAGCCG	0.681													22	26	---	---	---	---					
LA16c-23H5.4	0	broad.mit.edu	37	22	16419352	16419352	+	RNA	DEL	T	T	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr22:16419352delT	ENST00000444162.1	+	0	279																											GAATCGACGATTTTTTTTTTG	0.398													6	10	---	---	---	---					
