Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SYNJ2BP	55333	broad.mit.edu	37	14	70842394	70842394	+	Splice_Site	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:70842394C>T	ENST00000256366.4	-	3	377	c.297_splice	c.e3+1	p.R99_splice	RP11-718G2.3_ENST00000555276.1_RNA|SYNJ2BP_ENST00000554216.1_5'UTR	NM_018373.2	NP_060843.2			synaptojanin 2 binding protein											central_nervous_system(1)|kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	5				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		GATACCTACCCTGTGCTGCAC	0.463000													22	112					0	0	0.667858	0	0
SRSF4	6429	broad.mit.edu	37	1	29508253	29508253	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:29508253C>T	ENST00000373795.4	-	1	246	c.12G>A	c.(10-12)gtG>gtA	p.V4V	SRSF4_ENST00000546138.1_Silent_p.V4V|SRSF4_ENST00000466448.1_5'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	4	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						GGCCGATGTACACCCGCGGCA	0.701000													5	36					0	0	0.184627	0	0
TTN	7273	broad.mit.edu	37	2	179587178	179587178	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:179587178C>A	ENST00000589042.1	-	77	22560	c.22336G>T	c.(22336-22338)Gca>Tca	p.A7446S	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.A7129S|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.A6202S|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7129	Ig-like 56.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGATGGGTGCAGAGCCATTT	0.393000													14	69					1.5842e-08	1.71745e-08	0.435327	1	0
NEUROD1	4760	broad.mit.edu	37	2	182542610	182542610	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:182542610G>A	ENST00000295108.3	-	2	1435	c.978C>T	c.(976-978)tgC>tgT	p.C326C	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	326					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TGGGGATCTCGCAGCGAGGGG	0.502000													10	102					0	0	0.335167	0	0
TTN	7273	broad.mit.edu	37	2	179433038	179433038	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:179433038C>T	ENST00000589042.1	-	326	78045	c.77821G>A	c.(77821-77823)Gtt>Att	p.V25941I	TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V24300I|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V16876I|TTN_ENST00000342175.6_Missense_Mutation_p.V17068I|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V23373I|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V17001I|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24300	Fibronectin type-III 89.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAGCAGAAACAACATCCCAT	0.383000													18	58					0	0	0.520397	0	0
KLF9	687	broad.mit.edu	37	9	73002724	73002724	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:73002724G>A	ENST00000377126.2	-	2	1963	c.703C>T	c.(703-705)Cga>Tga	p.R235*		NM_001206.2	NP_001197.1	Q13886	KLF9_HUMAN	Kruppel-like factor 9	235					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	9						TTTTTCGATCGCTTGATCATG	0.597000													14	69					0	0	0.479597	0	0
OPRK1	4986	broad.mit.edu	37	8	54141973	54141973	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:54141973C>T	ENST00000265572.3	-	4	1324	c.1027G>A	c.(1027-1029)Gac>Aac	p.D343N	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Missense_Mutation_p.D254N|OPRK1_ENST00000520287.1_Missense_Mutation_p.D343N	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	343					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding	p.D343N(1)		NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	AAGCAGAAGTCCCGGAAACAC	0.493000													6	59					0	0	0.217242	0	0
ABLIM3	22885	broad.mit.edu	37	5	148590346	148590346	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:148590346G>A	ENST00000506113.1	+	6	1115	c.633G>A	c.(631-633)gaG>gaA	p.E211E	ABLIM3_ENST00000326685.7_Silent_p.E211E|ABLIM3_ENST00000508983.1_Silent_p.E211E|RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000356541.3_Silent_p.E211E|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000309868.7_Silent_p.E211E|ABLIM3_ENST00000504238.1_Silent_p.E211E			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	211	LIM zinc-binding 4.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAAATGTGAGACTTGTGACC	0.478000													41	115					0	0	0.870114	0	0
GRIK3	2899	broad.mit.edu	37	1	37346378	37346378	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:37346378C>T	ENST00000373091.3	-	3	423	c.407G>A	c.(406-408)cGt>cAt	p.R136H	GRIK3_ENST00000373093.4_Missense_Mutation_p.R136H	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	136					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTGCTTCCAACGCAGCTGGAT	0.622000													4	84					0	0	0.184627	0	0
PTPDC1	138639	broad.mit.edu	37	9	96863938	96863938	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:96863938G>A	ENST00000375360.3	+	8	2282	c.1942G>A	c.(1942-1944)Gag>Aag	p.E648K	PTPDC1_ENST00000467049.1_3'UTR|PTPDC1_ENST00000288976.3_Missense_Mutation_p.E700K	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	648							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						GTCTTGGGTGGAGCAACTGAA	0.463000													14	88					0	0	0.539581	0	0
KIAA1919	91749	broad.mit.edu	37	6	111588141	111588141	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:111588141C>T	ENST00000368847.4	+	4	1729	c.1376C>T	c.(1375-1377)aCg>aTg	p.T459M		NM_153369.2	NP_699200.2	Q5TF39	NAGT1_HUMAN	KIAA1919	459					carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			large_intestine(3)|lung(2)|ovary(4)|skin(3)	12		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		ATGATTGAAACGAATGATACA	0.398000													5	50					0	0	0.184627	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	G	A	rs121913387		TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:21971186G>A	ENST00000304494.5	-	2	442	c.172C>T	c.(172-174)Cga>Tga	p.R58*	CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P72L|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R7*|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P113L|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P72L	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	58			R -> Q (in dbSNP:rs36204273).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R58*(78)|p.?(45)|p.M53_R58del(3)|p.P113L(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*88(2)|p.0(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.P113fs*>61(1)|p.R58fs*62(1)|p.R58fs*61(1)|p.G55fs*86(1)|p.R58R(1)|p.A57fs*85(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			4	14					0	0	0.150653	0	0
DEGS1	8560	broad.mit.edu	37	1	224377307	224377307	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:224377307G>A	ENST00000323699.4	+	2	277	c.111G>A	c.(109-111)atG>atA	p.M37I	DEGS1_ENST00000465848.1_3'UTR|DEGS1_ENST00000391877.3_Missense_Mutation_p.M37I	NM_003676.3	NP_003667.1	O15121	DEGS1_HUMAN	delta(4)-desaturase, sphingolipid 1	37					sphingolipid metabolic process|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	electron carrier activity|protein binding|sphingolipid delta-4 desaturase activity			breast(1)|kidney(3)|large_intestine(2)|lung(4)	10	Breast(184;0.193)			GBM - Glioblastoma multiforme(131;0.00643)		AGTCCTTGATGAAACCTGATC	0.313000													12	63					0	0	0.387290	0	0
CCNA1	8900	broad.mit.edu	37	13	37011811	37011811	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr13:37011811C>G	ENST00000418263.1	+	3	690	c.340C>G	c.(340-342)Cct>Gct	p.P114A	CCNA1_ENST00000449823.1_Missense_Mutation_p.P71A|CCNA1_ENST00000440264.1_Missense_Mutation_p.P71A|CCNA1_ENST00000463403.1_3'UTR|CCNA1_ENST00000255465.4_Missense_Mutation_p.P115A	NM_001111045.1|NM_003914.3	NP_001104515.1|NP_003905.1	P78396	CCNA1_HUMAN	cyclin A1	115					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		AAATGCCTTCCCTCCAGCTGG	0.478000													6	92					0	0	0.278610	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654375	38654375	+	RNA	SNP	A	A	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:38654375A>G	ENST00000494540.1	+	0	542					NR_003086.1																						CGGGAACTGGAGCCTCTCCTC	0.403000													5	32					0	0	0.248553	0	0
HIPK3	10114	broad.mit.edu	37	11	33308667	33308667	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:33308667G>A	ENST00000303296.4	+	2	1012	c.707G>A	c.(706-708)cGt>cAt	p.R236H	HIPK3_ENST00000456517.1_Missense_Mutation_p.R236H|HIPK3_ENST00000525975.1_Missense_Mutation_p.R236H|HIPK3_ENST00000379016.3_Missense_Mutation_p.R236H	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	236	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						TCTTATGCCCGTCAAGGTCAA	0.398000													3	32					0	0	0.150653	0	0
TOP2B	7155	broad.mit.edu	37	3	25639860	25639860	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr3:25639860C>T	ENST00000435706.2	-	36	5005	c.4804G>A	c.(4804-4806)Gta>Ata	p.V1602I	TOP2B_ENST00000542520.1_Missense_Mutation_p.V459I|TOP2B_ENST00000540199.1_Missense_Mutation_p.V459I|TOP2B_ENST00000264331.4_Missense_Mutation_p.V1607I			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	1607					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						AAATATTTTACTTCTTTCCTA	0.403000													11	43					0	0	0.361761	0	0
TMEM190	147744	broad.mit.edu	37	19	55889198	55889198	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:55889198G>A	ENST00000291934.3	+	4	267	c.249G>A	c.(247-249)gcG>gcA	p.A83A	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	83						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACATGTGGGCGCTGGTCTGGA	0.692000													5	64					0	0	0.217242	0	0
PTOV1	53635	broad.mit.edu	37	19	50357788	50357788	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:50357788C>T	ENST00000391842.1	+	2	467	c.297C>T	c.(295-297)ctC>ctT	p.L99L	PTOV1_ENST00000221557.9_Silent_p.L67L|PTOV1_ENST00000601638.1_Silent_p.L67L|PTOV1_ENST00000600603.1_Silent_p.L67L|AC018766.6_ENST00000601211.1_RNA|PTOV1_ENST00000601675.1_Silent_p.L99L|PTOV1_ENST00000599732.1_Silent_p.L99L|PTOV1_ENST00000598325.1_3'UTR	NM_017432.3	NP_059128.2	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane				endometrium(5)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)	16		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		GCGGCGTCCTCGAGTGGCAGG	0.672000													5	64					0	0	0.184627	0	0
KLKB1	3818	broad.mit.edu	37	4	187172684	187172684	+	Silent	SNP	A	A	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr4:187172684A>G	ENST00000264690.6	+	9	1099	c.912A>G	c.(910-912)ggA>ggG	p.G304G	KLKB1_ENST00000513864.1_Silent_p.G304G	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	304	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		ACTTTGGAGGAGAAGAATTGA	0.373000													3	73					0	0	0.115264	0	0
PRL	5617	broad.mit.edu	37	6	22294767	22294767	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:22294767G>A	ENST00000306482.1	-	2	593	c.75C>T	c.(73-75)agC>agT	p.S25S	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	25					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					AGGGGGCCACGCTCTGGCACA	0.592000													4	26					0	0	0.184627	0	0
ASTN2	23245	broad.mit.edu	37	9	119903652	119903652	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:119903652A>G	ENST00000313400.4	-	4	1221	c.1121T>C	c.(1120-1122)cTg>cCg	p.L374P	ASTN2_ENST00000361477.3_Intron|ASTN2_ENST00000373996.3_Missense_Mutation_p.L374P|ASTN2_ENST00000361209.2_Intron			O75129	ASTN2_HUMAN	astrotactin 2	374						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TGTGCTGCGCAGGGGTGGTTG	0.592000													3	49					0	0	0.115264	0	0
LRRN3	54674	broad.mit.edu	37	7	110764283	110764283	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:110764283C>T	ENST00000451085.1	+	4	2501	c.1455C>T	c.(1453-1455)ggC>ggT	p.G485G	IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000415362.1_Intron|LRRN3_ENST00000308478.5_Silent_p.G485G|IMMP2L_ENST00000447215.1_Intron|LRRN3_ENST00000422987.3_Silent_p.G485G|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000437687.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	485	Ig-like C2-type.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ATATAAATGGCGTAACTCCCA	0.408000													8	71					0	0	0.307466	0	0
GAB2	9846	broad.mit.edu	37	11	77991788	77991788	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:77991788C>G	ENST00000361507.4	-	2	320	c.235G>C	c.(235-237)Gag>Cag	p.E79Q	GAB2_ENST00000340149.2_Missense_Mutation_p.E41Q|GAB2_ENST00000526030.1_5'UTR	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	79	PH.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TCCTGCAGCTCCTTCTTGTTA	0.473000													19	136					0	0	0.592651	0	0
CD97	976	broad.mit.edu	37	19	14517888	14517888	+	Silent	SNP	G	G	A	rs141170739	byFrequency	TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:14517888G>A	ENST00000242786.5	+	18	2303	c.2223G>A	c.(2221-2223)acG>acA	p.T741T	CD97_ENST00000357355.3_Silent_p.T692T|CTC-548K16.5_ENST00000590626.1_RNA|CD97_ENST00000358600.3_Silent_p.T648T	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	741					cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TGACCATCACGGCCATCGCGC	0.637000													11	68					0	0	0.361761	0	0
TOP1MT	116447	broad.mit.edu	37	8	144392336	144392336	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:144392336C>T	ENST00000523676.1	-	14	1716	c.1311G>A	c.(1309-1311)gcG>gcA	p.A437A	TOP1MT_ENST00000521193.1_Silent_p.A437A|TOP1MT_ENST00000329245.4_Silent_p.A535A|TOP1MT_ENST00000519148.1_Silent_p.A437A			Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	535					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	CACTCAGCTGCGCCAGCTGCT	0.642000													4	23					0	0	0.150653	0	0
RGS9	8787	broad.mit.edu	37	17	63206625	63206625	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:63206625C>T	ENST00000449996.3	+	17	1372	c.1300C>T	c.(1300-1302)Cgg>Tgg	p.R434W	RGS9_ENST00000262406.9_Missense_Mutation_p.R437W|RGS9_ENST00000443584.3_Missense_Mutation_p.R434W	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	437					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						CCCTTTTATGCGGCGTCACCT	0.572000													4	128					0	0	0.150653	0	0
ATRX	546	broad.mit.edu	37	X	76937546	76937546	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chrX:76937546T>C	ENST00000373344.5	-	9	3416	c.3202A>G	c.(3202-3204)Aca>Gca	p.T1068A	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.T1030A	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1068					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CCTTTCCCTGTTGACTTCTCA	0.338000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						32	151					0	0	0.750413	0	0
IRX5	10265	broad.mit.edu	37	16	54966559	54966559	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:54966559C>T	ENST00000394636.4	+	2	736	c.399C>T	c.(397-399)aaC>aaT	p.N133N	IRX5_ENST00000558597.1_Silent_p.N67N|IRX5_ENST00000320990.5_Silent_p.N133N|IRX5_ENST00000560154.1_Intron			P78411	IRX5_HUMAN	iroquois homeobox 5	133					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						CCTGGCTCAACGAGCACCGCA	0.627000													18	88					0	0	0.539581	0	0
GPR98	84059	broad.mit.edu	37	5	90079036	90079036	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:90079036G>A	ENST00000405460.2	+	66	13423	c.13327G>A	c.(13327-13329)Gcc>Acc	p.A4443T	GPR98_ENST00000425867.2_Missense_Mutation_p.A104T	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4443					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GAGCTCCTCTGCCAGTCCCGG	0.443000													27	113					0	0	0.681144	0	0
DNAH2	146754	broad.mit.edu	37	17	7734412	7734412	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:7734412C>G	ENST00000572933.1	+	80	13699	c.12239C>G	c.(12238-12240)gCa>gGa	p.A4080G	DNAH2_ENST00000389173.2_Missense_Mutation_p.A4080G			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	4080					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGGTTGTCAGCACTGGAGACT	0.517000													4	301					0	0	0.150653	0	0
MRPL21	219927	broad.mit.edu	37	11	68658835	68658835	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:68658835C>T	ENST00000362034.2	-	7	591	c.582G>A	c.(580-582)cgG>cgA	p.R194R	MRPL21_ENST00000450904.2_Silent_p.R109R	NM_181514.1|NM_181515.1	NP_852615.1|NP_852616.1	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21	194					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(6)|prostate(1)	8			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGCTGTTTATCCGGAGGACAG	0.473000													12	235					0	0	0.435327	0	0
INTS12	57117	broad.mit.edu	37	4	106621141	106621141	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr4:106621141C>T	ENST00000451321.2	-	2	501	c.22G>A	c.(22-24)Gaa>Aaa	p.E8K	INTS12_ENST00000394735.1_Missense_Mutation_p.E8K|INTS12_ENST00000340139.5_Missense_Mutation_p.E8K	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	8					snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GGATCAAGTTCCAAGTTCACA	0.358000													37	85					0	0	0.819951	0	0
DBX1	120237	broad.mit.edu	37	11	20177857	20177857	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:20177857G>A	ENST00000524983.2	-	4	1223	c.935C>T	c.(934-936)tCg>tTg	p.S312L	DBX1_ENST00000227256.3_Missense_Mutation_p.S351L			A6NMT0	DBX1_HUMAN	developing brain homeobox 1	312					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)	21						GTGCGCGGGCGAGGGGGGCAG	0.701000													10	68					0	0	0.361761	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161578	90161578	+	RNA	SNP	G	G	A	rs13337896	by1000genomes	TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:90161578G>A	ENST00000564451.1	+	0	931				TUBB8P7_ENST00000567960.1_RNA														p.R105H(3)									GCCAAGGGACGCTACACCGAA	0.587000													4	40					0	0	0.150653	0	0
PSD2	84249	broad.mit.edu	37	5	139201499	139201499	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:139201499G>A	ENST00000274710.3	+	6	1324	c.1119G>A	c.(1117-1119)ccG>ccA	p.P373P		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	373	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCCTTCCCGCTGATGGGGG	0.587000													7	64					0	0	0.248553	0	0
VIT	5212	broad.mit.edu	37	2	36986255	36986255	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:36986255G>A	ENST00000457137.2	+	6	781	c.553G>A	c.(553-555)Gat>Aat	p.D185N	VIT_ENST00000389975.3_Intron|VIT_ENST00000401530.1_Intron|VIT_ENST00000379242.3_Intron|VIT_ENST00000497382.1_Intron|VIT_ENST00000379241.3_Intron|VIT_ENST00000404084.1_Intron	NM_001177972.1	NP_001171443.1	Q6UXI7	VITRN_HUMAN	vitrin	0						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				TGTTTTGGGAGATAGCGGAGA	0.458000													3	45					0	0	0.115264	0	0
MRPL45	84311	broad.mit.edu	37	17	36453192	36453192	+	Missense_Mutation	SNP	T	T	G	rs139299251	by1000genomes	TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:36453192T>G	ENST00000312513.5	+	1	204	c.43T>G	c.(43-45)Ttt>Gtt	p.F15V		NM_032351.4	NP_115727.4	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45	15					intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome			breast(3)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	13	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTTATCGAGGTTTTTGGGCTG	0.582000													5	60					0	0	0.307466	0	0
TENC1	23371	broad.mit.edu	37	12	53447568	53447568	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr12:53447568C>A	ENST00000314250.6	+	5	562	c.272C>A	c.(271-273)aCg>aAg	p.T91K	RP11-983P16.4_ENST00000546793.1_RNA|TENC1_ENST00000549700.1_Missense_Mutation_p.T91K|TENC1_ENST00000546602.1_Missense_Mutation_p.T91K|TENC1_ENST00000379902.3_5'UTR|TENC1_ENST00000552570.1_Missense_Mutation_p.T91K|RP11-983P16.4_ENST00000551890.1_RNA|TENC1_ENST00000314276.3_Missense_Mutation_p.T101K|RP11-983P16.4_ENST00000550601.1_RNA|TENC1_ENST00000451358.1_Missense_Mutation_p.T91K	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	91					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CGGCGAAACACGGCCCCAGTC	0.567000											OREG0021855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	35					0.000978159	0.00104098	0.387290	1	0
KMT2C	58508	broad.mit.edu	37	7	151949691	151949691	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:151949691C>T	ENST00000355193.2	-	10	1627	c.1409G>A	c.(1408-1410)tGt>tAt	p.C470Y	KMT2C_ENST00000262189.6_Missense_Mutation_p.C470Y					lysine (K)-specific methyltransferase 2C																		ACACTTCCCACAGAAGGGACA	0.388000													5	26					0	0	0.184627	0	0
KCNH4	23415	broad.mit.edu	37	17	40322231	40322231	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:40322231C>T	ENST00000264661.3	-	8	1616	c.1284G>A	c.(1282-1284)gcG>gcA	p.A428A	KCNH4_ENST00000607371.1_Silent_p.A428A	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	428					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGTACAGTGCCGCGATGTAGG	0.602000													15	27					0	0	0.457914	0	0
KAAG1	353219	broad.mit.edu	37	6	24357907	24357907	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:24357907G>A	ENST00000274766.1	+	1	777	c.40G>A	c.(40-42)Gtt>Att	p.V14I	DCDC2_ENST00000378454.3_Silent_p.N24N	NM_181337.3	NP_851854.1	Q9UBP8	KAAG1_HUMAN	kidney associated antigen 1	14					immune response					central_nervous_system(1)|lung(1)|prostate(1)	3						AGGGGTCCCCGTTGCGGTACA	0.662000													9	59					0	0	0.335167	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669125	234669125	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:234669125C>T	ENST00000360418.3	+	1	192	c.192C>T	c.(190-192)gcC>gcT	p.A64A	UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A1_ENST00000305208.5_Silent_p.A64A|UGT1A3_ENST00000482026.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A4_ENST00000373409.3_Intron			P22309	UD11_HUMAN		64					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CACCTGACGCCTCGTTGTACA	0.522000													11	88					0	0	0.387290	0	0
ZFPM1	161882	broad.mit.edu	37	16	88601287	88601287	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:88601287G>C	ENST00000319555.3	+	10	3243	c.2921G>C	c.(2920-2922)cGg>cCg	p.R974P		NM_153813.2	NP_722520.2	Q8IX07	FOG1_HUMAN	zinc finger protein, FOG family member 1	974					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)|ovary(2)|urinary_tract(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GGCAACCACCGGTACTGCCGT	0.662000													7	40					0	0	0.307466	0	0
DMBT1	1755	broad.mit.edu	37	10	124339094	124339094	+	Splice_Site	SNP	G	G	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:124339094G>T	ENST00000368909.3	+	10	786	c.679_splice	c.e10-1	p.G227_splice	DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000344338.3_Splice_Site_p.G227_splice|DMBT1_ENST00000368955.3_Splice_Site_p.G227_splice|DMBT1_ENST00000368956.2_Splice_Site_p.G227_splice|DMBT1_ENST00000330163.4_Splice_Site_p.G227_splice|DMBT1_ENST00000338354.3_Splice_Site_p.G227_splice	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	227					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCCCCTGTAGGATCTGAATCC	0.527000													39	391					6.19805e-25	6.91321e-25	0.812448	1	0
PYROXD2	84795	broad.mit.edu	37	10	100148126	100148126	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:100148126C>T	ENST00000370575.4	-	13	1480	c.1432G>A	c.(1432-1434)Gct>Act	p.A478T	PYROXD2_ENST00000483923.1_Intron	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	478							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						TCTGCATAAGCGTCTCTCTCC	0.612000													8	26					0	0	0.307466	0	0
TCTEX1D4	343521	broad.mit.edu	37	1	45271807	45271807	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:45271807C>T	ENST00000372200.1	-	2	1042	c.534G>A	c.(532-534)ccG>ccA	p.P178P	TCTEX1D4_ENST00000339355.2_Silent_p.P178P	NM_001013632.2	NP_001013654.1	Q5JR98	TC1D4_HUMAN	Tctex1 domain containing 4	178										pancreas(1)	1	Acute lymphoblastic leukemia(166;0.155)					GGCCCGCGCGCGGCCCCAGCA	0.716000													6	6					0	0	0.217242	0	0
TMEM176A	55365	broad.mit.edu	37	7	150500820	150500820	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:150500820G>A	ENST00000484928.1	+	5	1036	c.455G>A	c.(454-456)cGc>cAc	p.R152H	TMEM176A_ENST00000461345.1_Missense_Mutation_p.R93H|TMEM176A_ENST00000004103.3_Missense_Mutation_p.R152H			Q96HP8	T176A_HUMAN	transmembrane protein 176A	152						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGTGCCTGCCGCATCTCCAGC	0.512000													29	74					0	0	0.729181	0	0
SAR1A	56681	broad.mit.edu	37	10	71921643	71921643	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:71921643T>C	ENST00000373238.1	-	2	386	c.29A>G	c.(28-30)aAt>aGt	p.N10S	SAR1A_ENST00000373242.1_Missense_Mutation_p.N10S|SAR1A_ENST00000477464.1_5'UTR|SAR1A_ENST00000458634.2_Intron|SAR1A_ENST00000373241.4_Missense_Mutation_p.N10S|SAR1A_ENST00000431664.2_Missense_Mutation_p.N10S|SAR1A_ENST00000373236.1_Missense_Mutation_p.N10S			Q9NR31	SAR1A_HUMAN	SAR1 homolog A (S. cerevisiae)	10					ER to Golgi vesicle-mediated transport|intracellular protein transport	Golgi apparatus	GTP binding|GTPase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)	6						GCTGAAGCCATTGTAGATCCA	0.358000													4	31					0	0	0.184627	0	0
SPAG16	79582	broad.mit.edu	37	2	214878680	214878680	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:214878680G>A	ENST00000331683.5	+	13	1501	c.1406G>A	c.(1405-1407)aGa>aAa	p.R469K	SPAG16_ENST00000374309.3_Missense_Mutation_p.R375K	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	469					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TATAGTGAAAGATGCAGATGT	0.338000													10	73					0	0	0.435327	0	0
PCYT2	5833	broad.mit.edu	37	17	79866789	79866789	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:79866789G>A	ENST00000538936.2	-	3	411	c.303C>T	c.(301-303)acC>acT	p.T101T	PCYT2_ENST00000538721.2_Silent_p.T101T|PCYT2_ENST00000571105.1_Silent_p.T101T|PCYT2_ENST00000331285.3_Silent_p.T23T|PCYT2_ENST00000570388.1_Silent_p.T23T|PCYT2_ENST00000570391.1_Silent_p.T69T	NM_001256435.1|NM_002861.3	NP_001243364.1|NP_002852.1	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	101	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity			breast(2)|endometrium(1)|lung(4)|ovary(1)	8	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			ATTTGTCCAGGGTCTCTAGTG	0.587000													10	84					0	0	0.361761	0	0
HMCN1	83872	broad.mit.edu	37	1	186106021	186106021	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:186106021C>T	ENST00000271588.4	+	87	13763	c.13534C>T	c.(13534-13536)Cga>Tga	p.R4512*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.R4512*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4512	Ig-like C2-type 44.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.R4512R(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATGTGTTGCTCGAAACTTAAT	0.428000													29	71					0	0	0.717897	0	0
CHGA	1113	broad.mit.edu	37	14	93397703	93397703	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:93397703C>A	ENST00000216492.5	+	6	744	c.464C>A	c.(463-465)cCg>cAg	p.P155Q	CHGA_ENST00000334654.4_Intron|CHGA_ENST00000553866.1_3'UTR	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	155					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		CAGGCCCTCCCGGAGCCCATG	0.607000													3	36					0.004672	0.00492684	0.115264	1	0
GDF5	8200	broad.mit.edu	37	20	34022565	34022565	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr20:34022565C>T	ENST00000374372.1	-	4	1151	c.648G>A	c.(646-648)gtG>gtA	p.V216V	GDF5OS_ENST00000374375.1_Silent_p.T203T|GDF5_ENST00000374369.3_Silent_p.V216V			P43026	GDF5_HUMAN	growth differentiation factor 5	216					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GCTTCCTGACCACGGGACCTC	0.612000													38	151					0	0	0.827153	0	0
ENPP6	133121	broad.mit.edu	37	4	185012424	185012424	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr4:185012424A>C	ENST00000296741.2	-	8	1370	c.1229T>G	c.(1228-1230)gTg>gGg	p.V410G		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	410					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		CATGCACATCACCCTGGACCA	0.587000													6	76					0	0	0.387290	0	0
FCRL4	83417	broad.mit.edu	37	1	157551405	157551405	+	Missense_Mutation	SNP	C	C	T	rs143188744	byFrequency	TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:157551405C>T	ENST00000271532.1	-	7	1300	c.1165G>A	c.(1165-1167)Gcc>Acc	p.A389T	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	389						integral to membrane|plasma membrane	receptor activity	p.A389T(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GCTCCCGCGGCGACAAGGCCA	0.572000													5	21					0	0	0.184627	0	0
EXOC6	54536	broad.mit.edu	37	10	94818062	94818062	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:94818062G>A	ENST00000371552.4	+	22	2379	c.2350G>A	c.(2350-2352)Gtc>Atc	p.V784I	EXOC6_ENST00000371547.4_Missense_Mutation_p.V805I|EXOC6_ENST00000443748.2_Missense_Mutation_p.V686I|EXOC6_ENST00000260762.6_Missense_Mutation_p.V789I	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	789					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				GATAGAGACAGTCGTGAAACA	0.398000													8	43					0	0	0.307466	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	63					0	0	0.500413	0	0
OGT	8473	broad.mit.edu	37	X	70776891	70776891	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chrX:70776891C>T	ENST00000373719.3	+	10	1473	c.1256C>T	c.(1255-1257)aCg>aTg	p.T419M	OGT_ENST00000373701.3_Missense_Mutation_p.T409M	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	419					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					CAGTGTTATACGCGTGCCATC	0.403000													3	17					0	0	0.115264	0	0
LHFPL3	375612	broad.mit.edu	37	7	104377219	104377219	+	Silent	SNP	T	T	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:104377219T>C	ENST00000535008.1	+	4	667	c.543T>C	c.(541-543)ctT>ctC	p.L181L	LHFPL3_ENST00000401970.2_Silent_p.L167L|LHFPL3_ENST00000424859.1_Silent_p.L167L|LHFPL3_ENST00000543266.1_Silent_p.L181L			Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	167						integral to membrane				kidney(1)|large_intestine(2)|lung(6)	9						AGTACACTCTTGGGGCTTGCT	0.473000													7	25					0	0	0.278610	0	0
KRTAP5-2	440021	broad.mit.edu	37	11	1619077	1619077	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:1619077G>C	ENST00000412090.1	-	1	447	c.404C>G	c.(403-405)tCc>tGc	p.S135C	KRTAP5-AS1_ENST00000424148.1_RNA	NM_001004325.1	NP_001004325.1	Q701N4	KRA52_HUMAN	keratin associated protein 5-2	135	6 X 4 AA repeats of C-C-X-P.					keratin filament				large_intestine(1)|lung(2)|skin(1)	4		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCAGCAGCTGGACTGGCAGCA	0.622000													16	188					0	0	0.479597	0	0
OR4D1	26689	broad.mit.edu	37	17	56232955	56232955	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:56232955C>T	ENST00000268912.5	+	1	462	c.441C>T	c.(439-441)gcC>gcT	p.A147A		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TGGTAGTAGCCGCCTGGGTGG	0.532000													21	59					0	0	0.575678	0	0
OBSCN	84033	broad.mit.edu	37	1	228468013	228468013	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:228468013C>T	ENST00000570156.2	+	34	9158	c.9084C>T	c.(9082-9084)aaC>aaT	p.N3028N	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.N2599N|OBSCN_ENST00000422127.1_Silent_p.N2599N|OBSCN_ENST00000359599.6_Silent_p.N1446N|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2029	Ig-like 30.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCCTGTACAACGACAGCTTCC	0.627000													3	16					0	0	0.115264	0	0
SLC52A2	79581	broad.mit.edu	37	8	145584283	145584283	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:145584283G>A	ENST00000532887.1	+	4	1618	c.1035G>A	c.(1033-1035)ctG>ctA	p.L345L	SLC52A2_ENST00000530047.1_Silent_p.L345L|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000329994.2_Silent_p.L345L|SLC52A2_ENST00000527078.1_Silent_p.L345L|SLC52A2_ENST00000540505.1_Silent_p.L257L|SLC52A2_ENST00000402965.1_Silent_p.L345L			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	345						integral to plasma membrane	receptor activity|riboflavin transporter activity										TCTCTCTGCTGGGCGTGTTCT	0.692000													24	112					0	0	0.654019	0	0
ST14	6768	broad.mit.edu	37	11	130078332	130078332	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:130078332C>T	ENST00000278742.5	+	17	2440	c.2022C>T	c.(2020-2022)gcC>gcT	p.A674A		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	674	Peptidase S1.			A -> V (in Ref. 3; BAB20376).	proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	AGTGGACGGCCTTCCTGGGCT	0.662000													12	36					0	0	0.411799	0	0
ENKD1	84080	broad.mit.edu	37	16	67700077	67700077	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:67700077G>A	ENST00000243878.4	-	2	498	c.177C>T	c.(175-177)atC>atT	p.I59I	ENKD1_ENST00000602644.1_Silent_p.I59I	NM_032140.1	NP_115516.1			enkurin domain containing 1																		CACCGGGACCGATGCAGGGGC	0.697000													5	59					0	0	0.184627	0	0
ICAM5	7087	broad.mit.edu	37	19	10404565	10404565	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:10404565G>A	ENST00000221980.4	+	7	1720	c.1657G>A	c.(1657-1659)Gaa>Aaa	p.E553K		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	553	Ig-like C2-type 6.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			TTACCGCTGCGAAGCCACCAA	0.652000													12	42					0	0	0.387290	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420192	56420192	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:56420192G>T	ENST00000407595.2	+	2	1359	c.857G>T	c.(856-858)tGc>tTc	p.C286F	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	286	His-rich.									breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AAACCCTTGTGCAAGGGCAGC	0.632000													16	84					4.14922e-12	4.5839e-12	0.500413	1	0
NDNL2	56160	broad.mit.edu	37	15	29561416	29561416	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr15:29561416G>A	ENST00000332303.4	-	1	617	c.494C>T	c.(493-495)gCc>gTc	p.A165V	FAM189A1_ENST00000261275.4_Intron	NM_138704.3	NP_619649.1	Q96MG7	MAGG1_HUMAN	necdin-like 2	165	MAGE.				regulation of growth	cytoplasm|nucleus				breast(3)|large_intestine(2)|lung(3)	8		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CCTCATCTCGGCATCCTCCTC	0.547000													4	111					0	0	0.150653	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198808	170198808	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr3:170198808C>T	ENST00000231706.4	-	7	1578	c.1263G>A	c.(1261-1263)ttG>ttA	p.L421L	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	421						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AGACAGAGACCAAGGTGTAGG	0.532000													14	91					0	0	0.435327	0	0
SHARPIN	81858	broad.mit.edu	37	8	145154029	145154029	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:145154029G>A	ENST00000398712.2	-	7	1438	c.1002C>T	c.(1000-1002)ccC>ccT	p.P334P		NM_030974.3	NP_112236.3	Q9H0F6	SHRPN_HUMAN	SHANK-associated RH domain interactor	334					negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(2)|ovary(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGGGCCTGGGGGTAGCCCCA	0.662000													3	41					0	0	0.115264	0	0
RASA1	5921	broad.mit.edu	37	5	86674234	86674234	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:86674234G>A	ENST00000456692.2	+	18	1950	c.1835G>A	c.(1834-1836)cGa>cAa	p.R612Q	RASA1_ENST00000506290.1_Missense_Mutation_p.R623Q|RASA1_ENST00000512763.1_Missense_Mutation_p.R622Q|RASA1_ENST00000274376.6_Missense_Mutation_p.R789Q	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	789	C2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding	p.R789Q(1)		NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		ACCCTATTTCGAGCCACAACA	0.353000													13	32					0	0	0.411799	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561118	44561118	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr18:44561118G>A	ENST00000332567.4	-	1	870	c.518C>T	c.(517-519)aCg>aTg	p.T173M	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	173					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGCTGTGCGCGTTGGAGAGGC	0.687000													7	71					0	0	0.248553	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40293317	40293317	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr15:40293317C>A	ENST00000263791.5	+	21	3094	c.3051C>A	c.(3049-3051)caC>caA	p.H1017Q	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.H989Q	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1017					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TGCTGCACCACACGCTGACCA	0.587000													6	39					3.59834e-05	3.86488e-05	0.217242	1	0
ATP8A2	51761	broad.mit.edu	37	13	26343230	26343230	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr13:26343230C>T	ENST00000381655.2	+	26	2573	c.2431C>T	c.(2431-2433)Cgg>Tgg	p.R811W	ATP8A2_ENST00000255283.8_Missense_Mutation_p.R771W|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	771					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.R811R(1)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GGTGAAGAAGCGGGTGAAGGC	0.537000													22	62					0	0	0.624587	0	0
MALAT1	378938	broad.mit.edu	37	11	65266557	65266557	+	RNA	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:65266557C>T	ENST00000534336.1	+	0	1325					NR_002819.2																						GCTGAGGGGGCAGGCGGAGCT	0.458000													4	105					0	0	0.184627	0	0
ZNF716	441234	broad.mit.edu	37	7	57522286	57522286	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:57522286T>C	ENST00000420713.1	+	2	272	c.160T>C	c.(160-162)Tcc>Ccc	p.S54P		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AAACCTGGTCTCCCTGGGTGA	0.368000													4	64					0	0	0.150653	0	0
ATXN1	6310	broad.mit.edu	37	6	16328463	16328463	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:16328463C>T	ENST00000244769.4	-	8	1015	c.79G>A	c.(79-81)Gag>Aag	p.E27K	ATXN1_ENST00000436367.1_Missense_Mutation_p.E27K	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	27					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GCCTTCTCCTCGGAGGACCGG	0.687000													6	70					0	0	0.248553	0	0
LRP4	4038	broad.mit.edu	37	11	46894742	46894742	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:46894742G>A	ENST00000378623.1	-	30	4734	c.4492C>T	c.(4492-4494)Cgg>Tgg	p.R1498W	LRP4-AS1_ENST00000531719.1_RNA|LRP4-AS1_ENST00000502049.2_RNA	NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1498					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		AAGTTTGCCCGTTCGATCTTG	0.552000													6	52					0	0	0.217242	0	0
EPDR1	54749	broad.mit.edu	37	7	37988474	37988474	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:37988474G>C	ENST00000199448.4	+	2	681	c.302G>C	c.(301-303)gGa>gCa	p.G101A	EPDR1_ENST00000425345.1_Missense_Mutation_p.G40A|EPDR1_ENST00000559325.1_Missense_Mutation_p.G221A|EPDR1_ENST00000476620.1_5'UTR|EPDR1_ENST00000423717.1_Intron	NM_017549.4	NP_060019.2	Q9UM22	EPDR1_HUMAN	ependymin related 1	101					cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						TATAAGGATGGAGTGATGTTT	0.423000													4	51					0	0	0.184627	0	0
CCDC47	57003	broad.mit.edu	37	17	61829244	61829244	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:61829244C>A	ENST00000582252.1	-	12	1604	c.1427G>T	c.(1426-1428)tGt>tTt	p.C476F	RP11-51F16.8_ENST00000580553.1_Intron|CCDC47_ENST00000225726.5_Intron|CCDC47_ENST00000403162.3_Intron			Q96A33	CCD47_HUMAN	coiled-coil domain containing 47	0						integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	18						ACCAACAGAACACAAGCAGTC	0.368000													30	78					4.22769e-11	4.62653e-11	0.706142	1	0
TAS2R60	338398	broad.mit.edu	37	7	143141158	143141158	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:143141158C>T	ENST00000332690.1	+	1	613	c.613C>T	c.(613-615)Ccc>Tcc	p.P205S	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	205					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					TTGGACAATGCCCACTGCTGT	0.448000													4	152					0	0	0.150653	0	0
STAB2	55576	broad.mit.edu	37	12	104089380	104089380	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr12:104089380G>C	ENST00000388887.2	+	32	3632	c.3428G>C	c.(3427-3429)cGg>cCg	p.R1143P		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1143	FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CTGCTCATGCGGCTGGAACAG	0.502000													28	99					0	0	0.760397	0	0
USP9X	8239	broad.mit.edu	37	X	41077799	41077799	+	Silent	SNP	G	G	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chrX:41077799G>A	ENST00000324545.7	+	37	7017	c.6384G>A	c.(6382-6384)ttG>ttA	p.L2128L	USP9X_ENST00000378308.2_Silent_p.L2128L	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	2128					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						ATTTTTCCTTGCAAGATGGGC	0.413000													37	44					0	0	0.834066	0	0
AKNAD1	254268	broad.mit.edu	37	1	109369904	109369904	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:109369904T>C	ENST00000370001.3	-	11	2127	c.1859A>G	c.(1858-1860)aAg>aGg	p.K620R	AKNAD1_ENST00000369994.1_Missense_Mutation_p.K590R|AKNAD1_ENST00000369995.3_Missense_Mutation_p.K620R|AKNAD1_ENST00000357393.4_Missense_Mutation_p.K327R	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	620										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						TCCGTGGCCCTTTTTCTCCAC	0.413000													3	185					0	0	0.115264	0	0
EPB41L3	23136	broad.mit.edu	37	18	5396229	5396229	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr18:5396229T>G	ENST00000341928.2	-	19	3284	c.2944A>C	c.(2944-2946)Acc>Ccc	p.T982P	EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000427684.2_Missense_Mutation_p.T279P|EPB41L3_ENST00000542146.1_Missense_Mutation_p.T287P|EPB41L3_ENST00000544123.1_Missense_Mutation_p.T813P|EPB41L3_ENST00000540638.2_Missense_Mutation_p.T760P|EPB41L3_ENST00000400111.3_Missense_Mutation_p.T760P|EPB41L3_ENST00000342933.3_Missense_Mutation_p.T982P	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	982	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						ATGGTTTTGGTTTCGGTGTGA	0.458000													5	187					0	0	0.184627	0	0
EXTL3	2137	broad.mit.edu	37	8	28573798	28573798	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:28573798C>T	ENST00000220562.4	+	3	1124	c.222C>T	c.(220-222)tgC>tgT	p.C74C	EXTL3_ENST00000523149.1_Intron|EXTL3_ENST00000519886.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	74						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		ACGAGCTGTGCGAGGTGAAGC	0.602000													12	55					0	0	0.387290	0	0
GALNT16	57452	broad.mit.edu	37	14	69787431	69787431	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:69787431A>T	ENST00000337827.4	+	2	508	c.181A>T	c.(181-183)Aca>Tca	p.T61S	GALNT16_ENST00000553669.1_Missense_Mutation_p.T61S|GALNT16_ENST00000448469.3_Missense_Mutation_p.T61S	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		ATCTCAGGTGACAGGAACTCC	0.607000													7	86					0	0	0.278610	0	0
TC2N	123036	broad.mit.edu	37	14	92258736	92258736	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:92258736T>A	ENST00000435962.2	-	9	1345	c.1022A>T	c.(1021-1023)gAt>gTt	p.D341V	TC2N_ENST00000360594.5_Missense_Mutation_p.D341V|TC2N_ENST00000340892.5_Missense_Mutation_p.D341V|TC2N_ENST00000556018.1_Intron	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	341						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		TGGTGTTATATCCAAAGAGTA	0.363000													22	69					0	0	0.608945	0	0
DCAF15	90379	broad.mit.edu	37	19	14070879	14070879	+	Silent	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:14070879C>T	ENST00000254337.6	+	10	1545	c.1524C>T	c.(1522-1524)ctC>ctT	p.L508L		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	508										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						AGGGCCAGCTCCGGTGAGCGC	0.667000											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	25					0	0	0.150653	0	0
PKHD1	5314	broad.mit.edu	37	6	51875151	51875151	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:51875151C>T	ENST00000371117.3	-	35	5982	c.5707G>A	c.(5707-5709)Gtc>Atc	p.V1903I	PKHD1_ENST00000340994.4_Missense_Mutation_p.V1903I	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1903					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.V1903I(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GTAATCTTGACGGTAATTGGC	0.393000													6	37					0	0	0.217242	0	0
UNC5D	137970	broad.mit.edu	37	8	35606140	35606140	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:35606140C>T	ENST00000287272.2	+	11	1675	c.1655C>T	c.(1654-1656)cCg>cTg	p.P552L	UNC5D_ENST00000416672.1_Missense_Mutation_p.P626L|UNC5D_ENST00000453357.2_Missense_Mutation_p.P616L|UNC5D_ENST00000449677.1_Missense_Mutation_p.P197L|UNC5D_ENST00000420357.1_Missense_Mutation_p.P554L|UNC5D_ENST00000404895.2_Missense_Mutation_p.P621L			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	621	ZU5.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGACCATCCCGCACTGTGCA	0.493000													5	116					0	0	0.184627	0	0
ZNF549	256051	broad.mit.edu	37	19	58049987	58049987	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:58049987A>G	ENST00000376233.3	+	4	1796	c.1615A>G	c.(1615-1617)Agc>Ggc	p.S539G	ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.S526G|ZNF549_ENST00000594943.1_Intron	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	539					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAAGTCTTCAGCCACCAAAA	0.443000													4	56					0	0	0.150653	0	0
TIMD4	91937	broad.mit.edu	37	5	156378745	156378747	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:156378745_156378747delTTG	ENST00000274532.2	-	3	511_513	c.455_457delCAA	c.(454-459)agc>a	p.TS152del	TIMD4_ENST00000407087.3_In_Frame_Del_p.TS152del	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	152	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGTGGGGCTTGTTGTTGTTGT	0.537													7	481	---	---	---	---					
CNPY3	10695	broad.mit.edu	37	6	42897358	42897360	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:42897358_42897360delTGC	ENST00000372836.4	+	1	421_423	c.50_52delTGC	c.(49-54)ttg>t	p.LL23del	CNPY3_ENST00000394142.3_In_Frame_Del_p.LL23del	NM_006586.3	NP_006577.2	Q9BT09	CNPY3_HUMAN	canopy FGF signaling regulator 3	23					innate immune response	endoplasmic reticulum		p.L25delL(1)		central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)	6	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTTCTTCCCTtgctgctgctgct	0.695													3	5	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23299147	23299147	+	RNA	DEL	A	A	-			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr15:23299147delA	ENST00000560464.1	-	0	4510																											ACATTCAAAGAAAAAAAAAAA	0.313													2	4	---	---	---	---					
NPIPA8	101059953	broad.mit.edu	37	16	18441114	18441116	+	Splice_Site	DEL	CAC	CAC	-			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:18441114_18441116delCAC	ENST00000339303.5	-	1	15		c.e1+1							nuclear pore complex interacting protein family, member A8																		CGGCCATACTCACCACTGGGACT	0.709													6	12	---	---	---	---					
SPTBN4	57731	broad.mit.edu	37	19	41073713	41073714	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:41073713_41073714insC	ENST00000352632.3	+	31	6567_6568	c.6481_6482insC	c.(6481-6483)ccgfs	p.P2161fs	SPTBN4_ENST00000392025.1_Frame_Shift_Ins_p.P904fs|SPTBN4_ENST00000598249.1_Frame_Shift_Ins_p.P2161fs			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2161					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGAGCCCCTGGCCCGCCGAGCC	0.718													2	4	---	---	---	---					
