Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GGA3	23163	broad.mit.edu	37	17	73239164	73239164	+	Missense_Mutation	SNP	C	C	A	rs35542883		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:73239164C>A	ENST00000245541.6	-	6	724	c.508G>T	c.(508-510)Gat>Tat	p.D170Y	GGA3_ENST00000538886.1_Missense_Mutation_p.D48Y|GGA3_ENST00000537686.1_Intron|GGA3_ENST00000351904.7_Missense_Mutation_p.D137Y|GGA3_ENST00000582486.1_Missense_Mutation_p.D98Y|GGA3_ENST00000578348.1_Missense_Mutation_p.D48Y|GGA3_ENST00000582717.1_Missense_Mutation_p.D98Y	NM_138619.2	NP_619525.1	Q9NZ52	GGA3_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	170	Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			breast(2)|endometrium(3)|large_intestine(4)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	20			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TCCTCATCATCAAAAACAGGG	0.547000													5	284					1	1	1	1	0
SLC13A5	284111	broad.mit.edu	37	17	6606290	6606290	+	Splice_Site	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:6606290C>T	ENST00000433363.2	-	5	948	c.716_splice	c.e5+1	p.E239_splice	SLC13A5_ENST00000293800.6_Splice_Site_p.E222_splice|SLC13A5_ENST00000381074.4_Splice_Site_p.E196_splice|SLC13A5_ENST00000573648.1_Splice_Site_p.E239_splice	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	239						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						AGGACTCACTCGTTCATCTGG	0.647000													22	95					0	0	1	0	0
C6orf58	352999	broad.mit.edu	37	6	127911331	127911331	+	Silent	SNP	A	A	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr6:127911331A>G	ENST00000329722.7	+	5	786	c.774A>G	c.(772-774)agA>agG	p.R258R		NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	258						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		CCTTGATTAGATCATATAAGT	0.408000													68	145					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51411725	51411725	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:51411725G>A	ENST00000319760.6	-	1	723	c.671C>T	c.(670-672)aCt>aTt	p.T224I		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				CTGACTGTAAGTTTTAAGGGA	0.413000													13	102					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21598482	21598482	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr7:21598482A>T	ENST00000328843.6	+	3	589	c.558A>T	c.(556-558)caA>caT	p.Q186H	DNAH11_ENST00000409508.3_Missense_Mutation_p.Q186H			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	186	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTACTTCACAAGATATGGAAT	0.333000									Kartagener syndrome				4	26					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													4	52					0	0	1	0	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.471_splice	c.e5+1	p.H157_splice	RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000452145.2_Splice_Site_p.H132_splice|AGAP10_ENST00000413193.2_Splice_Site_p.H228_splice					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													3	63					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21991022	21991022	+	Silent	SNP	G	G	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr12:21991022G>T	ENST00000261200.4	-	28	3555	c.3556C>A	c.(3556-3558)Cgg>Agg	p.R1186R	RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000261201.4_Silent_p.R1186R|ABCC9_ENST00000345162.2_Silent_p.R1150R	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1186	ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTAAAGGCCCGAATGGTGGTG	0.418000													3	62					1	1	1	1	0
SLC22A25	387601	broad.mit.edu	37	11	62997044	62997044	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:62997044G>C	ENST00000306494.6	-	1	80	c.81C>G	c.(79-81)ttC>ttG	p.F27L	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	27					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CTATGACGTTGAACATTATAA	0.463000													5	123					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91642836	91642836	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chrX:91642836C>G	ENST00000373094.1	+	5	4092	c.3247C>G	c.(3247-3249)Cat>Gat	p.H1083D	PCDH11X_ENST00000298274.8_Missense_Mutation_p.H1046D|PCDH11X_ENST00000504220.1_Intron|PCDH11X_ENST00000406881.1_Missense_Mutation_p.H1083D|PCDH11X_ENST00000373097.1_Missense_Mutation_p.H1073D|PCDH11X_ENST00000361655.2_Missense_Mutation_p.H1073D|PCDH11X_ENST00000373088.1_Missense_Mutation_p.H1046D	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1083					homophilic cell adhesion	integral to plasma membrane	calcium ion binding	p.H1083Y(1)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CAGCACATCTCATGGCCTGCC	0.552000													38	134					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69922039	69922039	+	Silent	SNP	C	C	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:69922039C>A	ENST00000359154.2	+	8	902	c.801C>A	c.(799-801)ccC>ccA	p.P267P	WWP2_ENST00000356003.2_Silent_p.P267P|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000448661.1_Silent_p.P267P|WWP2_ENST00000542271.1_Silent_p.P151P|WWP2_ENST00000569174.1_Silent_p.P267P	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	267					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCCCGAATCCCAACACGACTT	0.617000													20	78					4.35082e-09	4.77381e-09	1	1	0
ILF3	3609	broad.mit.edu	37	19	10793296	10793296	+	Silent	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:10793296G>A	ENST00000449870.1	+	13	1781	c.1464G>A	c.(1462-1464)gcG>gcA	p.A488A	ILF3_ENST00000250241.8_Silent_p.A488A|ILF3_ENST00000588657.1_Silent_p.A488A|ILF3_ENST00000592763.1_Silent_p.A488A|ILF3_ENST00000589998.1_Silent_p.A488A|ILF3_ENST00000590261.1_Silent_p.A488A|ILF3_ENST00000318511.3_Silent_p.A488A|ILF3_ENST00000420083.1_Silent_p.A488A|ILF3_ENST00000407004.3_Silent_p.A488A	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	488					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			AGACCGAGGCGAAGCCAGCAG	0.642000													6	51					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7605584	7605584	+	Silent	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:7605584G>A	ENST00000221249.6	+	9	1097	c.666G>A	c.(664-666)ctG>ctA	p.L222L	PNPLA6_ENST00000414982.3_Silent_p.L270L|PNPLA6_ENST00000450331.3_Silent_p.L222L|PNPLA6_ENST00000600737.1_Silent_p.L261L|PNPLA6_ENST00000545201.2_Silent_p.L222L	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	261					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						TCAGCATCCTGGATGTCATCA	0.587000													5	127					0	0	1	0	0
IQCG	84223	broad.mit.edu	37	3	197665623	197665623	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:197665623G>A	ENST00000265239.6	-	5	735	c.311C>T	c.(310-312)aCg>aTg	p.T104M	IQCG_ENST00000455191.1_Missense_Mutation_p.T104M|IQCG_ENST00000453254.1_Missense_Mutation_p.T104M|IQCG_ENST00000480302.1_5'UTR	NM_032263.3	NP_115639.1	Q9H095	IQCG_HUMAN	IQ motif containing G	104										autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GTCTAGATTCGTTCCTTCTAG	0.358000													32	1085					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032800	30032800	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:30032800G>A	ENST00000328224.6	-	2	2659	c.1426C>T	c.(1426-1428)Cgg>Tgg	p.R476W		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	476						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCCAGTTCCCGCATGCTGGCT	0.522000													8	79					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43708124	43708124	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr21:43708124C>G	ENST00000398437.1	+	10	1685	c.1537C>G	c.(1537-1539)Ctt>Gtt	p.L513V	ABCG1_ENST00000398457.2_Missense_Mutation_p.L369V|ABCG1_ENST00000347800.2_Missense_Mutation_p.L364V|ABCG1_ENST00000343687.3_Missense_Mutation_p.L378V|ABCG1_ENST00000398449.3_Missense_Mutation_p.L367V|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000361802.2_Missense_Mutation_p.L367V|ABCG1_ENST00000340588.4_Missense_Mutation_p.L475V			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	367	ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	GAACCCTTTTCTTTGGCACCG	0.567000													17	238					0	0	1	0	0
ZGPAT	84619	broad.mit.edu	37	20	62340307	62340307	+	Silent	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:62340307C>T	ENST00000328969.5	+	2	502	c.375C>T	c.(373-375)gaC>gaT	p.D125D	ZGPAT_ENST00000490623.1_3'UTR|ZGPAT_ENST00000448100.1_Silent_p.D125D|ZGPAT_ENST00000369967.3_Silent_p.D125D|ZGPAT_ENST00000355969.6_Silent_p.D125D|ZGPAT_ENST00000357119.4_Silent_p.D125D	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	125	Poly-Glu.				negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					agggagaggacgaggaagagC	0.637000													5	70					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117532358	117532358	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chrX:117532358C>T	ENST00000254029.3	+	8	1594	c.1199C>T	c.(1198-1200)gCg>gTg	p.A400V	WDR44_ENST00000371822.5_Missense_Mutation_p.A375V|WDR44_ENST00000371825.3_Missense_Mutation_p.A400V	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	400						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						AGTAATGACGCGGCACAGTCA	0.358000													36	95					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152732580	152732580	+	Silent	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:152732580C>T	ENST00000368773.1	+	2	574	c.516C>T	c.(514-516)tgC>tgT	p.C172C	KPRP_ENST00000606109.1_Silent_p.C172C	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	172	Gln-rich.					cytoplasm		p.C172C(1)		NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCAGTGTGCCAGCCTCAGG	0.522000													4	137					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43318580	43318580	+	Silent	SNP	T	T	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:43318580T>A	ENST00000374518.4	+	20	3210	c.3147T>A	c.(3145-3147)tcT>tcA	p.S1049S		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1049					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGTTTAATTCTGCCTTGGAAG	0.403000													4	165					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98740378	98740378	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr9:98740378C>G	ENST00000407474.3	+	2	829	c.316C>G	c.(316-318)Cag>Gag	p.Q106E				Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	0					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TCACTCAAACCAGAATGTAAT	0.388000													20	67					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31602803	31602803	+	Silent	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr14:31602803C>T	ENST00000399332.1	-	23	4145	c.3657G>A	c.(3655-3657)ggG>ggA	p.G1219G	HECTD1_ENST00000553700.1_Silent_p.G1219G	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1219					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TGGCATTTTTCCCCATCTGTT	0.403000													27	101					0	0	1	0	0
VPS4A	27183	broad.mit.edu	37	16	69349972	69349972	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:69349972C>T	ENST00000254950.11	+	2	239	c.83C>T	c.(82-84)gCg>gTg	p.A28V	VPS4A_ENST00000569775.1_3'UTR|RP11-343C2.3_ENST00000570054.2_Missense_Mutation_p.A52V	NM_013245.2	NP_037377.1	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting 4 homolog A (S. cerevisiae)	28	Interaction with CHMP1B.|MIT.				cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				TACGAGGAGGCGCTGCGGCTG	0.577000													4	115					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52639289	52639289	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr12:52639289G>A	ENST00000331817.5	+	7	1261	c.1078G>A	c.(1078-1080)Gcc>Acc	p.A360T	KRT7_ENST00000552322.1_3'UTR|RP3-416H24.1_ENST00000546686.1_RNA	NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	360	Coil 2.|Rod.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		GCTGGAAGCCGCCCTGCAGCG	0.652000													5	54					0	0	1	0	0
CCT6P1	643253	broad.mit.edu	37	7	65222986	65222986	+	RNA	SNP	G	G	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr7:65222986G>T	ENST00000442266.1	+	0	578																											GAATTCTGGCGTTTTTTACAA	0.289000													3	24					2.56e-06	2.77041e-06	1	1	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342186	60342186	+	RNA	SNP	T	T	C	rs79096325		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:60342186T>C	ENST00000581291.1	-	0	1967																				breast(2)|kidney(1)|lung(2)	5						GCTGGGGGTGTTGGGAGGGGC	0.498000													3	15					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102822797	102822797	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:102822797C>T	ENST00000260302.3	-	5	771	c.743G>A	c.(742-744)gGc>gAc	p.G248D	MMP13_ENST00000340273.4_Missense_Mutation_p.G248D	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	248					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding	p.G248D(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GTGGCTTTTGCCGGTGTAGGT	0.448000													5	292					0	0	1	0	0
SC5D	6309	broad.mit.edu	37	11	121178029	121178029	+	Silent	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:121178029T>C	ENST00000264027.4	+	5	1082	c.708T>C	c.(706-708)ttT>ttC	p.F236F	SC5D_ENST00000534230.1_Intron|SC5D_ENST00000392789.2_Silent_p.F236F	NM_006918.4	NP_008849.2			sterol-C5-desaturase																		ATATGTTCTTTGACTATAATT	0.413000													10	191					0	0	1	0	0
QTRT1	81890	broad.mit.edu	37	19	10823854	10823854	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:10823854C>T	ENST00000250237.5	+	10	1130	c.1120C>T	c.(1120-1122)Cgg>Tgg	p.R374W		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	374					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GGACTTCGTGCGGGACTTCAT	0.657000													20	97					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345055	33345055	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:33345055T>C	ENST00000374796.2	-	8	4066	c.1496A>G	c.(1495-1497)cAg>cGg	p.Q499R	NCOA6_ENST00000359003.2_Missense_Mutation_p.Q499R			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	499	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CTGTGGCCCCTGGTTTGGTGG	0.488000													6	273					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78195395	78195395	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:78195395G>T	ENST00000361193.3	+	3	316	c.36G>T	c.(34-36)agG>agT	p.R12S	SLC26A11_ENST00000411502.3_Missense_Mutation_p.R12S|SLC26A11_ENST00000571602.1_3'UTR|SLC26A11_ENST00000572725.1_Missense_Mutation_p.R12S|SLC26A11_ENST00000546047.2_Missense_Mutation_p.R12S	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	12						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GTCAGGCCAGGTCCTCTGGCC	0.687000													7	19					0.00621372	0.00663356	1	1	0
FZD1	8321	broad.mit.edu	37	7	90895605	90895605	+	Silent	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr7:90895605C>T	ENST00000287934.2	+	1	1823	c.1410C>T	c.(1408-1410)ggC>ggT	p.G470G		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	470					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			AGGTGGACGGCGATGTGCTGA	0.622000													5	209					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129877950	129877950	+	Silent	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:129877950G>A	ENST00000254667.3	+	20	2298	c.2019G>A	c.(2017-2019)gtG>gtA	p.V673V	PTPRE_ENST00000306042.5_Silent_p.V615V|PTPRE_ENST00000419012.2_Silent_p.V673V	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	673	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CACATATGGTGCAAACCCTGG	0.383000													27	100					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10207138	10207138	+	Missense_Mutation	SNP	G	G	A	rs147329205		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:10207138G>A	ENST00000377157.3	+	18	2907	c.1846G>A	c.(1846-1848)Gca>Aca	p.A616T	UBE4B_ENST00000343090.6_Missense_Mutation_p.A861T|UBE4B_ENST00000253251.8_Missense_Mutation_p.A732T	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	861					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding	p.A732T(1)|p.A861T(1)		NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CCTGGACCCCGCATATCCCGA	0.493000													4	208					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1250512	1250512	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:1250512C>T	ENST00000348261.5	+	7	1308	c.1060C>T	c.(1060-1062)Ccc>Tcc	p.P354S	CACNA1H_ENST00000565831.1_Missense_Mutation_p.P354S|CACNA1H_ENST00000358590.4_Missense_Mutation_p.P354S	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	354					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TGACTCCAACCCCCACAACGG	0.652000													3	67					0	0	1	0	0
DLX3	1747	broad.mit.edu	37	17	48070809	48070809	+	Silent	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:48070809G>A	ENST00000434704.2	-	2	696	c.471C>T	c.(469-471)ccC>ccT	p.P157P	DLX3_ENST00000512495.2_Silent_p.P37P	NM_005220.2	NP_005211.1	O60479	DLX3_HUMAN	distal-less homeobox 3	157						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	12						CGGCGCGCTCGGGCAGCGCCA	0.706000													7	22					0	0	1	0	0
TMEM202	338949	broad.mit.edu	37	15	72691006	72691006	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr15:72691006G>A	ENST00000341689.3	+	2	148	c.94G>A	c.(94-96)Gcc>Acc	p.A32T	TMEM202_ENST00000567679.1_Intron	NM_001080462.1	NP_001073931.1	A6NGA9	TM202_HUMAN	transmembrane protein 202	32						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	18						TACCGTCCCTGCCAAGAAACA	0.532000													17	65					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584875	7584875	+	Silent	SNP	C	C	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr6:7584875C>A	ENST00000379802.3	+	24	7721	c.7380C>A	c.(7378-7380)acC>acA	p.T2460T	DSP_ENST00000418664.2_Silent_p.T1861T	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2460	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAAGAATACCCTCAGGAAGC	0.418000													4	188					1	1	1	1	0
CHST6	4166	broad.mit.edu	37	16	75512887	75512887	+	Silent	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:75512887C>T	ENST00000332272.4	-	3	1019	c.840G>A	c.(838-840)ccG>ccA	p.P280P	CHST6_ENST00000390664.2_Silent_p.P280P|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	280					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TTTCTGCCAGCGGCTCCCGCG	0.662000													15	49					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8825333	8825333	+	Silent	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr18:8825333G>A	ENST00000359865.3	+	15	3967	c.3825G>A	c.(3823-3825)gaG>gaA	p.E1275E	SOGA2_ENST00000306329.11_Silent_p.E1594E|SOGA2_ENST00000400050.3_Silent_p.E1234E|SOGA2_ENST00000517570.1_Silent_p.E1234E|SOGA2_ENST00000306285.7_Silent_p.E600E|SOGA2_ENST00000518815.1_Silent_p.E600E	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1585																	ACAGCCTGGAGATGTCCAAGA	0.617000													20	51					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385748	58385748	+	Missense_Mutation	SNP	G	G	A	rs145250945		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:58385748G>A	ENST00000435989.2	-	3	1244	c.1010C>T	c.(1009-1011)gCt>gTt	p.A337V	ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000597342.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	337					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.A337V(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ACTGAAGCTAGCATATTTGCT	0.353000													3	11					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49494659	49494659	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:49494659G>A	ENST00000323798.3	-	2	396	c.200C>T	c.(199-201)cCg>cTg	p.P67L	GYS1_ENST00000540532.1_Intron|GYS1_ENST00000457974.1_5'UTR|GYS1_ENST00000544287.1_Intron|GYS1_ENST00000541188.1_Intron|GYS1_ENST00000263276.6_Missense_Mutation_p.P67L	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	67					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CTCCGTGTACGGCCCCACCAG	0.637000													6	291					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70617286	70617286	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chrX:70617286G>A	ENST00000449580.1	+	23	3638	c.3587G>A	c.(3586-3588)cGc>cAc	p.R1196H	TAF1_ENST00000423759.1_Missense_Mutation_p.R1217H|TAF1_ENST00000276072.3_Missense_Mutation_p.R1217H|TAF1_ENST00000373790.4_Missense_Mutation_p.R1196H			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	1196					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GCCTATGTGCGCATACGGACT	0.463000													4	205					0	0	1	0	0
SAMD4A	23034	broad.mit.edu	37	14	55168922	55168922	+	Silent	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr14:55168922T>C	ENST00000251091.5	+	2	644	c.339T>C	c.(337-339)atT>atC	p.I113I	SAMD4A_ENST00000555112.1_3'UTR|SAMD4A_ENST00000357634.3_Silent_p.I112I|SAMD4A_ENST00000554335.1_Silent_p.I113I|SAMD4A_ENST00000392067.3_Silent_p.I113I	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	113					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						CTCACTCTATTGAACACAACC	0.483000													26	88					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37904081	37904081	+	Silent	SNP	G	G	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:37904081G>T	ENST00000316950.6	-	6	2036	c.1479C>A	c.(1477-1479)ccC>ccA	p.P493P	ZNF569_ENST00000392150.2_Silent_p.P334P|ZNF569_ENST00000392149.2_Silent_p.P493P	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	493					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCATTCATAGGGTTTCTCTC	0.353000													31	92					2.65835e-16	3.00013e-16	1	1	0
SNRNP200	23020	broad.mit.edu	37	2	96970571	96970571	+	Silent	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:96970571G>A	ENST00000323853.5	-	2	158	c.81C>T	c.(79-81)ctC>ctT	p.L27L	SNRNP200_ENST00000349783.5_Silent_p.L27L	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	27						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TCCGGTCAATGAGAGAACGGT	0.507000													22	45					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132441028	132441028	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:132441028C>A	ENST00000326682.8	-	1	248	c.172G>T	c.(172-174)Ggg>Tgg	p.G58W	NPHP3_ENST00000337331.5_Missense_Mutation_p.G58W|NPHP3-AS1_ENST00000489343.1_RNA|NPHP3_ENST00000343113.4_Missense_Mutation_p.G58W|NPHP3_ENST00000383282.2_Missense_Mutation_p.G58W			Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	58					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ggcagcgacccgggcccggcc	0.766000													2	2					1	1	1	1	0
GDF9	2661	broad.mit.edu	37	5	132199856	132199856	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr5:132199856T>C	ENST00000378673.2	-	2	1236	c.370A>G	c.(370-372)Aag>Gag	p.K124E	GDF9_ENST00000296875.2_Missense_Mutation_p.K124E|GDF9_ENST00000464378.1_5'UTR			O60383	GDF9_HUMAN	growth differentiation factor 9	124					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAGCCTGCTTGTGCCGGGTA	0.468000													3	190					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			139	67					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205038678	205038678	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:205038678G>A	ENST00000331830.4	+	17	2469	c.2185G>A	c.(2185-2187)Gtc>Atc	p.V729I		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	729	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGAGCTCATCGTCAACTGGAC	0.612000													3	34					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13368242	13368242	+	Silent	SNP	G	G	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:13368242G>T	ENST00000360228.5	-	28	4511	c.4512C>A	c.(4510-4512)atC>atA	p.I1504I	CACNA1A_ENST00000573710.2_Silent_p.I1505I	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1505					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AGGCCACAAAGATATTGACAA	0.502000													14	31					2.61681e-11	2.91167e-11	1	1	0
ABCC11	85320	broad.mit.edu	37	16	48221269	48221269	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:48221269C>T	ENST00000394747.1	-	20	3125	c.2776G>A	c.(2776-2778)Gac>Aac	p.D926N	ABCC11_ENST00000356608.2_Missense_Mutation_p.D926N|ABCC11_ENST00000353782.5_Missense_Mutation_p.D926N|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000394748.1_Missense_Mutation_p.D926N|ABCC11_ENST00000537808.1_3'UTR	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	926	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TGTTCCAAGTCCCCTGCGAAG	0.527000													21	37					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72840467	72840467	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:72840467C>T	ENST00000293190.5	-	12	2677	c.2531G>A	c.(2530-2532)cGc>cAc	p.R844H	GRIN2C_ENST00000347612.4_Missense_Mutation_p.R844H	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	844					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CACCGAGTGGCGCAGCTTCCA	0.617000													4	110					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197896796	197896796	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:197896796T>C	ENST00000367390.3	+	5	809	c.782T>C	c.(781-783)aTg>aCg	p.M261T	LHX9_ENST00000367391.1_Missense_Mutation_p.M261T|LHX9_ENST00000337020.2_Missense_Mutation_p.M270T|LHX9_ENST00000367387.4_Missense_Mutation_p.M270T|LHX9_ENST00000561173.1_Missense_Mutation_p.M276T	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	270					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						ACCAAGCGCATGCGAACCTCT	0.522000													9	348					0	0	1	0	0
CCDC110	256309	broad.mit.edu	37	4	186379447	186379447	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr4:186379447C>T	ENST00000307588.3	-	6	2369	c.2294G>A	c.(2293-2295)cGg>cAg	p.R765Q	CCDC110_ENST00000393540.3_Missense_Mutation_p.R728Q|CCDC110_ENST00000510617.1_Missense_Mutation_p.R765Q	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	765						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTGAAGATGCCGCATCTCAAA	0.308000													18	46					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906486	164906486	+	Silent	SNP	A	A	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:164906486A>G	ENST00000475390.1	-	2	2576	c.2133T>C	c.(2131-2133)gaT>gaC	p.D711D	SLITRK3_ENST00000241274.3_Silent_p.D711D			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	711						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						cacctccaccaTCCTCAAACA	0.582000										HNSCC(40;0.11)			14	72					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159490676	159490676	+	Silent	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:159490676G>A	ENST00000389757.3	+	9	1562	c.1437G>A	c.(1435-1437)gcG>gcA	p.A479A	PKP4_ENST00000389759.3_Silent_p.A479A	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	479					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						CTACCTACGCGGAGCCCTACA	0.458000										HNSCC(62;0.18)			4	206					0	0	1	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81444997	81444997	+	RNA	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:81444997T>C	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							ACAACAATTTTCGGGCTTGCA	0.612000													2	6					0	0	1	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641567	106641567	+	RNA	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr14:106641567G>A	ENST00000390605.2	-	0	405																											TGTGTCTCTCGCACAGTAATA	0.532000													82	210					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	48098552	48098552	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:48098552G>A	ENST00000371741.4	-	1	632	c.466C>T	c.(466-468)Cgg>Tgg	p.R156W		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	156					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCCCGCTCCCGTAGGGTCTCG	0.582000													46	117					0	0	1	0	0
PDHA1	5160	broad.mit.edu	37	X	19369427	19369427	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chrX:19369427G>A	ENST00000379806.5	+	5	579	c.434G>A	c.(433-435)gGc>gAc	p.G145D	PDHA1_ENST00000379805.3_Missense_Mutation_p.G107D|PDHA1_ENST00000422285.2_Missense_Mutation_p.G107D|PDHA1_ENST00000545074.1_Missense_Mutation_p.G114D|PDHA1_ENST00000540249.1_Missense_Mutation_p.G107D	NM_001173454.1	NP_001166925.1	P08559	ODPA_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 1	107					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)	18	Hepatocellular(33;0.183)				NADH(DB00157)	CTGGAGGCCGGCATCAACCCC	0.507000													6	222					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108448071	108448071	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:108448071A>G	ENST00000263054.6	-	10	1446	c.1439T>C	c.(1438-1440)tTg>tCg	p.L480S	SORCS1_ENST00000344440.6_Missense_Mutation_p.L480S|SORCS1_ENST00000369698.1_Missense_Mutation_p.L15S	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	480						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTTGTTAGCCAAGAACATTCC	0.403000													3	96					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152461285	152461285	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr6:152461285G>A	ENST00000367255.5	-	140	25859	c.25258C>T	c.(25258-25260)Cga>Tga	p.R8420*	SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000265368.4_Nonsense_Mutation_p.R8420*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.R8372*|SYNE1_ENST00000354674.4_Nonsense_Mutation_p.R598*|SYNE1_ENST00000356820.4_Nonsense_Mutation_p.R2944*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.R8032*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.R8372*|SYNE1_ENST00000539504.1_Nonsense_Mutation_p.R575*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8420					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGCTCCCATCGGTCAATCACA	0.453000										HNSCC(10;0.0054)			26	85					0	0	1	0	0
PCMT1	5110	broad.mit.edu	37	6	150111185	150111185	+	Silent	SNP	T	T	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr6:150111185T>C	ENST00000464889.1	+	4	746	c.462T>C	c.(460-462)ttT>ttC	p.F154F	PCMT1_ENST00000367384.2_Silent_p.F154F|PCMT1_ENST00000544496.1_Silent_p.F61F|PCMT1_ENST00000367378.1_Silent_p.F154F|PCMT1_ENST00000367380.5_Silent_p.F96F					protein-L-isoaspartate (D-aspartate) O-methyltransferase											kidney(1)|large_intestine(2)|lung(4)|ovary(1)	8		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.221)	OV - Ovarian serous cystadenocarcinoma(155;5.63e-13)|GBM - Glioblastoma multiforme(68;0.207)		CTGCATGTTTTGCACGTATGG	0.378000													4	200					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169642896	169642896	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:169642896G>C	ENST00000428432.2	+	5	651	c.262G>C	c.(262-264)Gaa>Caa	p.E88Q	SAMD7_ENST00000335556.3_Missense_Mutation_p.E88Q	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	88										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			CAGAAGGAATGAAATGATTCA	0.363000													3	105					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98237004	98237004	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr5:98237004G>C	ENST00000284049.3	-	5	622	c.473C>G	c.(472-474)tCt>tGt	p.S158C		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	158					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ACCAGACTGAGATGGAGATCC	0.348000													52	176					0	0	1	0	0
THAP9	79725	broad.mit.edu	37	4	83827690	83827690	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr4:83827690A>G	ENST00000302236.5	+	3	541	c.490A>G	c.(490-492)Aag>Gag	p.K164E		NM_024672.4	NP_078948.3	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	164							DNA binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(13)|lung(5)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(3)	33		Hepatocellular(203;0.114)				GATGATCAAGAAGAGAAAGGG	0.403000													49	117					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107032392	107032392	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:107032392T>G	ENST00000409886.3	-	21	5065	c.4978A>C	c.(4978-4980)Agt>Cgt	p.S1660R	RGPD3_ENST00000304514.7_Missense_Mutation_p.S1660R	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1660					intracellular transport		binding	p.S1660R(4)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						GTGGTGGAACTGAGCTTCTGA	0.383000													4	312					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278696	114278696	+	Silent	SNP	A	A	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr4:114278696A>G	ENST00000357077.4	+	38	8975	c.8922A>G	c.(8920-8922)gcA>gcG	p.A2974A	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.A2941A|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2941					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTGTAGTGGCAAGCTCCTCTA	0.408000													5	325					0	0	1	0	0
LOC100131564	100131564	broad.mit.edu	37	1	93744310	93744310	+	RNA	DEL	T	T	-			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:93744310delT	ENST00000451302.2	-	0	1008				RP4-717I23.3_ENST00000429859.1_RNA|RP4-717I23.3_ENST00000415150.1_RNA|RP4-717I23.3_ENST00000446528.2_RNA|RP4-717I23.3_ENST00000424517.3_RNA|RP4-717I23.3_ENST00000427669.1_RNA|RP4-717I23.3_ENST00000413606.1_RNA|RP4-717I23.3_ENST00000457025.1_RNA|RP4-717I23.3_ENST00000414430.1_RNA|RP4-717I23.3_ENST00000455474.1_RNA|RP4-717I23.3_ENST00000442860.1_RNA|RP4-717I23.3_ENST00000447577.1_RNA																							GGAATGCaaattttttttttt	0.279													3	5	---	---	---	---					
LAX1	54900	broad.mit.edu	37	1	203743036	203743038	+	In_Frame_Del	DEL	ACA	ACA	-			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:203743036_203743038delACA	ENST00000442561.2	+	5	814_816	c.424_426delACA	c.(424-426)del	p.T142del	LAX1_ENST00000367215.1_3'UTR|LAX1_ENST00000367217.5_In_Frame_Del_p.T126del	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	142					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCAGGAGCATACAGCCCACATCC	0.527													19	73	---	---	---	---					
OR2T35	403244	broad.mit.edu	37	1	248801602	248801603	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:248801602_248801603insCA	ENST00000317450.3	-	1	956_957	c.957_958insTG	c.(955-960)gttcagfs	p.Q320fs		NM_001001827.1	NP_001001827.1	Q8NGX2	O2T35_HUMAN	olfactory receptor, family 2, subfamily T, member 35	320					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I320fs*1(1)		endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	6	all_cancers(71;2.04e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCCTTCCTGATCACAGTCGCCA	0.545													4	8	---	---	---	---					
RNASEH1-AS1	100506054	broad.mit.edu	37	2	3608083	3608086	+	RNA	DEL	CTTC	CTTC	-	rs33945746	by1000genomes	TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:3608083_3608086delCTTC	ENST00000438436.1	+	0	789				AC108488.3_ENST00000426725.1_RNA	NR_038429.1																						TCTcttccttcttccttccttcct	0.451													3	5	---	---	---	---					
AGAP1	116987	broad.mit.edu	37	2	236817460	236817461	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:236817460_236817461insG	ENST00000409538.1	+	11	2525_2526	c.2029_2030insG	c.(2029-2031)agcfs	p.S677fs	AGAP1_ENST00000428334.2_Frame_Shift_Ins_p.S251fs|AGAP1_ENST00000304032.7_Frame_Shift_Ins_p.S412fs|AGAP1_ENST00000336665.5_Frame_Shift_Ins_p.S412fs			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	412	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GAGGCCACCCCGAGCCACGTCA	0.485													9	74	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1389456	1389457	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr4:1389456_1389457delCA	ENST00000324803.4	+	1	4117_4118	c.1157_1158delCA	c.(1156-1158)tfs	p.S386fs		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	386	Interaction with PAK1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCTGCCTGCTCACACACGTGCC	0.639													9	322	---	---	---	---					
BTN2A3P	54718	broad.mit.edu	37	6	26426984	26426984	+	RNA	DEL	T	T	-	rs79308421		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr6:26426984delT	ENST00000466808.2	+	0	1067																											GAACCTAGTCTTTTTTTTTTT	0.428													3	3	---	---	---	---					
CELP	1057	broad.mit.edu	37	9	135962465	135962465	+	RNA	DEL	T	T	-	rs63239560		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr9:135962465delT	ENST00000411440.2	+	0	972					NR_001275.2																						AGGATGCCCCTGTGCCCCTCA	0.677													5	5	---	---	---	---					
HELLS	3070	broad.mit.edu	37	10	96348062	96348062	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:96348062delT	ENST00000348459.5	+	13	1508	c.1403delT	c.(1402-1404)gtfs	p.V468fs	RP11-119K6.6_ENST00000432120.1_RNA|HELLS_ENST00000239026.6_3'UTR|HELLS_ENST00000394045.1_Frame_Shift_Del_p.V370fs|HELLS_ENST00000394036.1_3'UTR|HELLS_ENST00000371332.4_Frame_Shift_Del_p.V514fs	NM_018063.3	NP_060533.2	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	468					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		GAAGTAGTCGTTTATGCTCCA	0.363													35	82	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651191	1651199	+	In_Frame_Del	DEL	GGCTGTGGA	GGCTGTGGA	-	rs71025763		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:1651191_1651199delGGCTGTGGA	ENST00000399676.2	+	1	159_167	c.121_129delGGCTGTGGA	c.(121-129)del	p.GCG47del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	47						keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ctgtggctccggctgtggaggctgtgggg	0.713													32	16	---	---	---	---					
SNORD3B-2	780852	broad.mit.edu	37	17	18967365	18967377	+	RNA	DEL	TTCCTCGGGGTTT	TTCCTCGGGGTTT	-			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:18967365_18967377delTTCCTCGGGGTTT	ENST00000364880.1	-	0	72_84																											gctacctctcttcctcggggttttcggtgctct	0.502													10	54	---	---	---	---					
CTC-400I9.3	0	broad.mit.edu	37	19	31443058	31443059	+	RNA	INS	-	-	CTCC	rs144141390	by1000genomes	TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:31443058_31443059insCTCC	ENST00000587702.1	+	0	92																											tccctccctctctccctccctc	0.465													5	5	---	---	---	---					
ZNF337	26152	broad.mit.edu	37	20	25657231	25657232	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:25657231_25657232delTG	ENST00000376436.1	-	4	1231_1232	c.692_693delCA	c.(691-693)afs	p.T231fs	ZNF337_ENST00000252979.5_Frame_Shift_Del_p.T231fs|ZNF337_ENST00000538750.1_Frame_Shift_Del_p.T199fs|RP4-694B14.5_ENST00000455791.1_RNA|RP4-694B14.5_ENST00000439498.1_RNA|RP4-694B14.5_ENST00000414393.1_RNA					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						ACTTCTCTCCTGTGTGTGTGTT	0.510													7	184	---	---	---	---					
