Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TOPORS	10210	broad.mit.edu	37	9	32542338	32542338	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:32542338G>A	ENST00000360538.2	-	3	2301	c.2185C>T	c.(2185-2187)Cat>Tat	p.H729Y	TOPORS_ENST00000379858.1_Missense_Mutation_p.H664Y	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	729	Arg-rich.|Interaction with TOP1.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTAGAATAATGAGCTCTGGAC	0.378000													10	154					0	0	0.006214	0	0
NPSR1	387129	broad.mit.edu	37	7	34888178	34888178	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr7:34888178T>C	ENST00000360581.1	+	8	1056	c.928T>C	c.(928-930)Tat>Cat	p.Y310H	NPSR1_ENST00000359791.1_Missense_Mutation_p.Y310H|NPSR1_ENST00000531252.1_Missense_Mutation_p.Y299H|NPSR1_ENST00000381539.3_Missense_Mutation_p.Y310H|NPSR1_ENST00000381542.1_Missense_Mutation_p.Y244H	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	310						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	GGAGCGTTTCTATGCCTCTGT	0.498000													11	203					0	0	0.008291	0	0
NUP62	23636	broad.mit.edu	37	19	50412820	50412820	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:50412820G>A	ENST00000596217.1	-	2	2132	c.245C>T	c.(244-246)gCt>gTt	p.A82V	NUP62_ENST00000422090.2_Missense_Mutation_p.A82V|NUP62_ENST00000413454.1_Missense_Mutation_p.A82V|NUP62_ENST00000597029.1_Missense_Mutation_p.A82V|NUP62_ENST00000352066.3_Missense_Mutation_p.A82V|IL4I1_ENST00000595948.1_Intron|IL4I1_ENST00000341114.3_Intron|CTC-326K19.6_ENST00000451973.1_3'UTR|NUP62_ENST00000597723.1_Missense_Mutation_p.A82V			P37198	NUP62_HUMAN	nucleoporin 62kDa	82	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|stomach(1)|urinary_tract(2)	19		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCCCCCCGAAGCAAGAGTCGC	0.577000													14	131					0	0	0.001855	0	0
KIF4B	285643	broad.mit.edu	37	5	154393632	154393632	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:154393632G>A	ENST00000435029.4	+	1	373	c.213G>A	c.(211-213)ccG>ccA	p.P71P		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	71	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity	p.P71P(2)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAGTAGCGCCGCTCATAAAAG	0.463000													9	62					0	0	0.004482	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277533	140277533	+	Silent	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:140277533G>C	ENST00000458420.3	+	12	2065	c.1875G>C	c.(1873-1875)gtG>gtC	p.V625V		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	625					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						ATGCCTATGTGATGGTCCTCC	0.547000										HNSCC(16;0.037)			5	65					0	0	0.000602	0	0
PTPRC	5788	broad.mit.edu	37	1	198668699	198668699	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:198668699C>T	ENST00000367376.2	+	5	470	c.299C>T	c.(298-300)tCa>tTa	p.S100L	PTPRC_ENST00000594404.1_Intron|PTPRC_ENST00000391970.3_3'UTR|PTPRC_ENST00000348564.6_Intron|PTPRC_ENST00000352140.3_Missense_Mutation_p.S100L|PTPRC_ENST00000442510.2_Missense_Mutation_p.S102L	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	100					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TTAGGTGTTTCATCAGTACAG	0.488000											OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	72					0	0	0.009096	0	0
CELSR2	1952	broad.mit.edu	37	1	109806318	109806318	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:109806318C>T	ENST00000271332.3	+	9	4981	c.4920C>T	c.(4918-4920)ctC>ctT	p.L1640L		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1640	Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCTGGTACCTCAGCCTCATGT	0.652000											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	120					0	0	0.001984	0	0
ZNF391	346157	broad.mit.edu	37	6	27368887	27368887	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:27368887G>C	ENST00000244576.4	+	3	1283	c.738G>C	c.(736-738)gaG>gaC	p.E246D		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						ACACTGGAGAGAATCCCTATG	0.433000													3	44					0	0	0.004672	0	0
BMPR2	659	broad.mit.edu	37	2	203420620	203420620	+	Silent	SNP	T	T	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:203420620T>G	ENST00000374580.4	+	12	2771	c.2232T>G	c.(2230-2232)ccT>ccG	p.P744P	BMPR2_ENST00000374574.2_Intron	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	744					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						AGATCTATCCTCTCCCCAAGC	0.458000													5	72					0	0	0.001168	0	0
TRAP1	10131	broad.mit.edu	37	16	3736066	3736066	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:3736066G>A	ENST00000246957.5	-	4	490	c.402C>T	c.(400-402)gaC>gaT	p.D134D	TRAP1_ENST00000538171.1_Silent_p.D81D	NM_016292.2	NP_057376.2	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	134					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				GTGCTTGGCCGTCAGACACCA	0.532000													4	58					0	0	0.009096	0	0
OR5B12	390191	broad.mit.edu	37	11	58207492	58207492	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:58207492C>G	ENST00000302572.2	-	1	154	c.133G>C	c.(133-135)Gaa>Caa	p.E45Q		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGAATCAATTCAATCATCCCC	0.488000													5	49					0	0	0.000602	0	0
PHC3	80012	broad.mit.edu	37	3	169835109	169835109	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:169835109T>C	ENST00000494943.1	-	10	2130	c.2062A>G	c.(2062-2064)Ata>Gta	p.I688V	PHC3_ENST00000467570.1_Missense_Mutation_p.I647V|PHC3_ENST00000495893.1_Missense_Mutation_p.I700V			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	688					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTGTTCTCTATACTGGGAATG	0.448000													7	42					0	0	0.001984	0	0
TLN2	83660	broad.mit.edu	37	15	62942335	62942335	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr15:62942335G>A	ENST00000561311.1	+	4	419	c.189G>A	c.(187-189)tgG>tgA	p.W63*	TLN2_ENST00000306829.6_Nonsense_Mutation_p.W63*			Q9Y4G6	TLN2_HUMAN	talin 2	63					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AAGGGATTTGGCTGGAAGCGG	0.478000													7	87					0	0	0.003080	0	0
IFT81	28981	broad.mit.edu	37	12	110574583	110574583	+	Silent	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:110574583A>G	ENST00000242591.5	+	8	1205	c.699A>G	c.(697-699)ctA>ctG	p.L233L	IFT81_ENST00000552912.1_Silent_p.L233L|IFT81_ENST00000361948.4_Silent_p.L233L	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	233					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						TTTTAAAGCTATTTCATGCAG	0.348000													3	21					0	0	0.004672	0	0
AKAP6	9472	broad.mit.edu	37	14	33292535	33292535	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:33292535C>G	ENST00000280979.4	+	13	5686	c.5516C>G	c.(5515-5517)cCc>cGc	p.P1839R	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1839			P -> T (in a colorectal cancer sample; somatic mutation).		protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATGACCAATCCCTCTGATACT	0.373000													4	75					0	0	0.000602	0	0
FAT1	2195	broad.mit.edu	37	4	187530345	187530345	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:187530345G>A	ENST00000441802.2	-	16	10407	c.10198C>T	c.(10198-10200)Cga>Tga	p.R3400*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3400	Cadherin 31.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ACCGTTTCTCGGTCGAGAAGT	0.453000										HNSCC(5;0.00058)			8	33					0	0	0.006214	0	0
TP63	8626	broad.mit.edu	37	3	189526137	189526137	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:189526137A>G	ENST00000264731.3	+	4	490	c.401A>G	c.(400-402)tAt>tGt	p.Y134C	TP63_ENST00000392463.2_Missense_Mutation_p.Y40C|TP63_ENST00000392460.3_Missense_Mutation_p.Y134C|TP63_ENST00000392461.3_Missense_Mutation_p.Y40C|TP63_ENST00000320472.5_Missense_Mutation_p.Y134C|TP63_ENST00000437221.1_Missense_Mutation_p.Y40C|TP63_ENST00000440651.2_Missense_Mutation_p.Y134C|TP63_ENST00000354600.5_Missense_Mutation_p.Y40C|TP63_ENST00000418709.2_Missense_Mutation_p.Y134C|TP63_ENST00000449992.1_Intron|TP63_ENST00000382063.4_Intron|TP63_ENST00000456148.1_Missense_Mutation_p.Y40C	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	134					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCAGTCCCTATAACACAGAC	0.617000										HNSCC(45;0.13)			15	80					0	0	0.002450	0	0
VDR	7421	broad.mit.edu	37	12	48238570	48238570	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:48238570T>C	ENST00000229022.3	-	11	1524	c.1243A>G	c.(1243-1245)Acg>Gcg	p.T415A	VDR_ENST00000549336.1_Missense_Mutation_p.T415A|VDR_ENST00000535672.1_Missense_Mutation_p.T383A|VDR_ENST00000550325.1_Missense_Mutation_p.T465A|VDR_ENST00000395324.2_Missense_Mutation_p.T415A	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	415	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	ACAAGGGGCGTTAGCTTCATG	0.607000													4	31					0	0	0.009096	0	0
CYTH2	9266	broad.mit.edu	37	19	48981788	48981788	+	Missense_Mutation	SNP	A	A	G	rs144064799		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:48981788A>G	ENST00000427476.1	+	11	1354	c.1054A>G	c.(1054-1056)Atg>Gtg	p.M352V	CYTH2_ENST00000452733.2_Missense_Mutation_p.M351V	NM_004228.6|NM_017457.5	NP_004219.3|NP_059431.1	Q99418	CYH2_HUMAN	cytohesin 2	352	PH.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GGGAAACCACATGGTGTACCG	0.592000													3	54					0	0	0.004672	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633915	70633915	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:70633915C>G	ENST00000381269.2	-	2	1978	c.1225G>C	c.(1225-1227)Gag>Cag	p.E409Q	SLC8A3_ENST00000534137.1_Missense_Mutation_p.E409Q|SLC8A3_ENST00000357887.3_Missense_Mutation_p.E409Q|SLC8A3_ENST00000528359.1_Missense_Mutation_p.E409Q|SLC8A3_ENST00000356921.2_Missense_Mutation_p.E409Q	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	409	Calx-beta 1.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CCACAGTTCTCCAGGCACTGG	0.512000													15	106					0	0	0.004007	0	0
RARG	5916	broad.mit.edu	37	12	53609131	53609131	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:53609131G>A	ENST00000425354.2	-	5	908	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C	RARG_ENST00000543762.1_5'UTR|RARG_ENST00000543726.1_Missense_Mutation_p.R119C|RARG_ENST00000327550.3_Missense_Mutation_p.R69C|RARG_ENST00000394426.1_Missense_Mutation_p.R141C|RARG_ENST00000338561.5_Missense_Mutation_p.R130C	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	141					canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TACTGGCAGCGATTCCTGGTC	0.552000													8	85					0	0	0.004482	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25255343	25255343	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:25255343G>C	ENST00000328086.7	-	6	2547	c.1744C>G	c.(1744-1746)Ctg>Gtg	p.L582V		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	582					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		GAGTTAATCAGGGCATCCATC	0.532000													7	59					0	0	0.001984	0	0
KEAP1	9817	broad.mit.edu	37	19	10597384	10597384	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:10597384C>G	ENST00000171111.5	-	6	2366	c.1819G>C	c.(1819-1821)Gct>Cct	p.A607P	KEAP1_ENST00000393623.2_Missense_Mutation_p.A607P	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	607					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATGGTGACAGCCACGCCCACC	0.557000													8	122					0	0	0.003080	0	0
MMP7	4316	broad.mit.edu	37	11	102401427	102401427	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:102401427C>T	ENST00000260227.4	-	1	57	c.5G>A	c.(4-6)cGa>cAa	p.R2Q		NM_002423.3	NP_002414.1	P09237	MMP7_HUMAN	matrix metallopeptidase 7 (matrilysin, uterine)	2					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R2Q(1)		large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		CACGGTGAGTCGCATAGCTGC	0.547000													5	50					0	0	0.001984	0	0
TRIM24	8805	broad.mit.edu	37	7	138269634	138269634	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr7:138269634G>A	ENST00000343526.4	+	19	3306	c.3091G>A	c.(3091-3093)Gac>Aac	p.D1031N	TRIM24_ENST00000415680.2_Missense_Mutation_p.D997N			O15164	TIF1A_HUMAN	tripartite motif containing 24	1031					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						TTCAGATGATGACTTTGTACA	0.373000													4	46					0	0	0.009096	0	0
DLK2	65989	broad.mit.edu	37	6	43418618	43418618	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:43418618C>G	ENST00000357338.3	-	6	1511	c.811G>C	c.(811-813)Gtg>Ctg	p.V271L	DLK2_ENST00000414245.1_Missense_Mutation_p.V265L|DLK2_ENST00000372488.3_Missense_Mutation_p.V271L|DLK2_ENST00000372485.1_Missense_Mutation_p.V265L	NM_206539.1	NP_996262.1	Q6UY11	DLK2_HUMAN	delta-like 2 homolog (Drosophila)	271						integral to membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCAGGTACCACTACAGCTGAG	0.647000													6	63					0	0	0.001168	0	0
TRIML2	205860	broad.mit.edu	37	4	189022315	189022315	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:189022315C>G	ENST00000512729.1	-	3	599	c.225G>C	c.(223-225)caG>caC	p.Q75H	TRIML2_ENST00000326754.3_Missense_Mutation_p.Q75H|TRIML2_ENST00000536972.1_Missense_Mutation_p.Q125H	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	75							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CCTGCTGTCTCTGGAGATTCT	0.428000													5	45					0	0	0.001984	0	0
C22orf29	79680	broad.mit.edu	37	22	19839545	19839545	+	Silent	SNP	A	A	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr22:19839545A>T	ENST00000405640.1	-	2	908	c.240T>A	c.(238-240)ggT>ggA	p.G80G	GNB1L_ENST00000405009.1_Intron|C22orf29_ENST00000484072.1_Intron|GNB1L_ENST00000329517.6_Intron|GNB1L_ENST00000460402.1_Intron|C22orf29_ENST00000407472.1_Silent_p.G80G|GNB1L_ENST00000403325.1_Intron|C22orf29_ENST00000328554.4_Silent_p.G80G			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	80										NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					CAGCTAGGGGACCCCTTTCTG	0.627000													11	50					0	0	0.001855	0	0
GPR89A	653519	broad.mit.edu	37	1	145765384	145765384	+	Silent	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:145765384T>C	ENST00000313835.9	-	13	1289	c.1146A>G	c.(1144-1146)ctA>ctG	p.L382L	GPR89A_ENST00000462900.2_Silent_p.L357L|GPR89A_ENST00000534502.1_Silent_p.L357L|GPR89A_ENST00000454423.3_Silent_p.L262L			B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A	382					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity			breast(1)|large_intestine(3)|lung(1)|skin(1)	6	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TCTGTGCTAATAGCAGGACAA	0.328000													23	173					0	0	0.003954	0	0
YY1	7528	broad.mit.edu	37	14	100728656	100728656	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:100728656T>C	ENST00000262238.4	+	2	955	c.695T>C	c.(694-696)aTt>aCt	p.I232T		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	232					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				AAAAAAGATATTGACCATGAG	0.333000													4	47					0	0	0.009096	0	0
MCM3AP	8888	broad.mit.edu	37	21	47700039	47700039	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:47700039T>A	ENST00000397708.1	-	5	1789	c.1535A>T	c.(1534-1536)aAa>aTa	p.K512I	MCM3AP_ENST00000291688.1_Missense_Mutation_p.K512I			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	512					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					GGAAAAGGGTTTCTTATTGGG	0.483000													8	126					0	0	0.004482	0	0
ZNF563	147837	broad.mit.edu	37	19	12429679	12429679	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:12429679T>A	ENST00000293725.5	-	4	1365	c.1160A>T	c.(1159-1161)cAc>cTc	p.H387L		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						ACCTCCAGTGTGCATTATCAT	0.418000													13	144					0	0	0.002450	0	0
CHL1	10752	broad.mit.edu	37	3	369921	369921	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:369921G>A	ENST00000256509.2	+	5	911	c.269G>A	c.(268-270)gGa>gAa	p.G90E	CHL1_ENST00000397491.2_Missense_Mutation_p.G90E	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	90	Ig-like C2-type 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AACAATTCAGGAACATTCAGG	0.388000													6	94					0	0	0.003080	0	0
LHX9	56956	broad.mit.edu	37	1	197887087	197887087	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:197887087C>T	ENST00000367390.3	+	2	134	c.107C>T	c.(106-108)gCc>gTc	p.A36V	LHX9_ENST00000561173.1_Missense_Mutation_p.A51V|LHX9_ENST00000367391.1_Missense_Mutation_p.A36V|LHX9_ENST00000337020.2_Missense_Mutation_p.A45V|LHX9_ENST00000367387.4_Missense_Mutation_p.A45V|LHX9_ENST00000606127.1_3'UTR	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	45					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						AAGACTGAGGCCCGTCTGGCC	0.657000													7	79					0	0	0.001984	0	0
AMIGO2	347902	broad.mit.edu	37	12	47472579	47472579	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:47472579C>T	ENST00000266581.4	-	2	673	c.207G>A	c.(205-207)ctG>ctA	p.L69L	AMIGO2_ENST00000550413.1_Silent_p.L69L|AMIGO2_ENST00000321382.3_Silent_p.L69L|AMIGO2_ENST00000429635.1_Silent_p.L69L	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	69					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					GTCTCTTAATCAGTCTGAAAA	0.493000													7	66					0	0	0.001984	0	0
WASH3P	374666	broad.mit.edu	37	15	102516424	102516424	+	RNA	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr15:102516424G>T	ENST00000557932.1	+	0	1372																		p.P449P(4)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGCCGCCACCGCAGCAGCCAC	0.647000													4	62					0.00116845	0.00127231	0.001168	1	0
UBBP4	23666	broad.mit.edu	37	17	21730847	21730847	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:21730847G>T	ENST00000584755.1	+	2	546	c.149G>T	c.(148-150)cGg>cTg	p.R50L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R50L|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCGGGAAGATGGC	0.522000													3	36					0.004672	0.0049767	0.004672	1	0
CRYBG3	131544	broad.mit.edu	37	3	97598838	97598838	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:97598838T>A	ENST00000182096.4	+	3	1118	c.1054T>A	c.(1054-1056)Tat>Aat	p.Y352N		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						GATGGTTATCTATGATCTCCA	0.284000													10	59					0	0	0.006214	0	0
UBE2G2	7327	broad.mit.edu	37	21	46193489	46193489	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:46193489G>A	ENST00000345496.2	-	5	628	c.358C>T	c.(358-360)Ctg>Ttg	p.L120L	UBE2G2_ENST00000477954.1_5'UTR|UBE2G2_ENST00000330942.5_Silent_p.L92L	NM_003343.5	NP_003334.2	P60604	UB2G2_HUMAN	ubiquitin-conjugating enzyme E2G 2	120					protein K48-linked ubiquitination	cytosol	ATP binding|protein binding|ubiquitin-protein ligase activity			breast(3)|central_nervous_system(1)|lung(1)	5				Colorectal(79;0.0638)		ACCGACAGCAGGATCTTCTCC	0.637000													4	35					0	0	0.009096	0	0
TTC17	55761	broad.mit.edu	37	11	43513699	43513699	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:43513699G>T	ENST00000039989.4	+	23	3294	c.3280G>T	c.(3280-3282)Gtc>Ttc	p.V1094F		NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1094							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						TCTGGGCAATGTCTACGTGGC	0.478000													9	86					1.12685e-05	1.2408e-05	0.004482	1	0
SNX15	29907	broad.mit.edu	37	11	64802351	64802351	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:64802351C>T	ENST00000377244.3	+	4	419	c.289C>T	c.(289-291)Cga>Tga	p.R97*	SNX15_ENST00000301886.3_3'UTR	NM_013306.4|NM_147777.3	NP_037438.2|NP_680086.2	Q9NRS6	SNX15_HUMAN	sorting nexin 15	97	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity	p.R97*(1)		endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14						CGAGGAGCGGCGAAAGGGGGC	0.622000													4	48					0	0	0.001168	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412242	139412242	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:139412242A>C	ENST00000277541.6	-	8	1478	c.1403T>G	c.(1402-1404)cTg>cGg	p.L468R		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	468	EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AATCTGGTCCAGGCAGGTGGC	0.672000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			9	56					0	0	0.000978	0	0
EVC	2121	broad.mit.edu	37	4	5750014	5750014	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:5750014C>T	ENST00000382674.2	+	8	1263	c.1079C>T	c.(1078-1080)tCt>tTt	p.S360F	EVC_ENST00000264956.6_Missense_Mutation_p.S360F|EVC_ENST00000509451.1_Missense_Mutation_p.S360F			P57679	EVC_HUMAN	Ellis van Creveld syndrome	360					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				TTGTGCGATTCTCAGGAGCTG	0.488000													3	36					0	0	0.004672	0	0
LVRN	206338	broad.mit.edu	37	5	115327924	115327924	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:115327924G>A	ENST00000357872.4	+	5	1334	c.1210G>A	c.(1210-1212)Gaa>Aaa	p.E404K	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		404					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										TCAACTGACAGAAAAAAAGAC	0.388000													5	84					0	0	0.000602	0	0
ZNF668	79759	broad.mit.edu	37	16	31075507	31075507	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:31075507C>G	ENST00000538906.1	-	2	1058	c.274G>C	c.(274-276)Gcc>Ccc	p.A92P	ZNF668_ENST00000539836.3_Missense_Mutation_p.A115P|ZNF668_ENST00000535577.1_Missense_Mutation_p.A92P|ZNF668_ENST00000426488.2_Missense_Mutation_p.A115P|ZNF668_ENST00000394983.2_Missense_Mutation_p.A92P|ZNF668_ENST00000300849.4_Missense_Mutation_p.A92P	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GTCTTGTAGGCCTTGGGGCAT	0.667000													5	38					0	0	0.001168	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24523069	24523069	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:24523069C>T	ENST00000357578.3	+	7	1234	c.1089C>T	c.(1087-1089)gcC>gcT	p.A363A	ALDH5A1_ENST00000491546.1_Silent_p.A335A|ALDH5A1_ENST00000546278.1_Silent_p.A275A|ALDH5A1_ENST00000348925.2_Silent_p.A376A	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	363					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TCGCCGAGGCCATGAAGAAGA	0.428000													10	106					0	0	0.006214	0	0
APCDD1L	164284	broad.mit.edu	37	20	57035940	57035940	+	Missense_Mutation	SNP	G	G	A	rs147052922	byFrequency	TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr20:57035940G>A	ENST00000371149.3	-	4	1642	c.1412C>T	c.(1411-1413)tCg>tTg	p.S471L	APCDD1L_ENST00000439429.1_Missense_Mutation_p.S482L	NM_153360.1	NP_699191.1	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated 1-like	471						integral to membrane				large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(1)	18	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CTTCTGCAGCGATGGCCTGTG	0.627000													4	63					0	0	0.001168	0	0
HCFC1	3054	broad.mit.edu	37	X	153215722	153215722	+	Silent	SNP	G	G	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chrX:153215722G>C	ENST00000310441.7	-	24	6942	c.5976C>G	c.(5974-5976)ggC>ggG	p.G1992G	HCFC1_ENST00000369984.4_Silent_p.G2037G|HCFC1_ENST00000354233.3_Silent_p.G1923G	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1992					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGTGGCCGGGCCATAGCCCT	0.632000													7	32					0	0	0.004482	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214357	140214357	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:140214357C>G	ENST00000525929.1	+	1	389	c.389C>G	c.(388-390)cCt>cGt	p.P130R	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.P130R|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAACCCTCCGGTGTTC	0.592000													8	184					0	0	0.003080	0	0
PRDM1	639	broad.mit.edu	37	6	106553695	106553695	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:106553695A>G	ENST00000369096.4	+	5	1894	c.1660A>G	c.(1660-1662)Aga>Gga	p.R554G	PRDM1_ENST00000369089.3_Missense_Mutation_p.R420G|PRDM1_ENST00000369091.2_Missense_Mutation_p.R518G	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	554					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		TAAAAACAAAAGAAACATGAC	0.537000			"""D, N, Mis, F, S"""		DLBCL								4	50					0	0	0.009096	0	0
RASA1	5921	broad.mit.edu	37	5	86659189	86659189	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:86659189T>A	ENST00000456692.2	+	11	1062	c.947T>A	c.(946-948)tTa>tAa	p.L316*	RASA1_ENST00000506290.1_Nonsense_Mutation_p.L327*|RASA1_ENST00000274376.6_Nonsense_Mutation_p.L493*|RASA1_ENST00000512763.1_Nonsense_Mutation_p.L326*	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	493	SH3.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TGGAAAAATTTATATTTTATC	0.289000													10	33					0	0	0.008291	0	0
KIF14	9928	broad.mit.edu	37	1	200587425	200587425	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:200587425T>C	ENST00000367350.4	-	2	865	c.427A>G	c.(427-429)Atg>Gtg	p.M143V		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	143	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						TTCAGTGTCATTTTGACAGAA	0.348000													5	58					0	0	0.000602	0	0
TTC13	79573	broad.mit.edu	37	1	231061288	231061288	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:231061288G>A	ENST00000366661.4	-	13	1570	c.1563C>T	c.(1561-1563)ttC>ttT	p.F521F	TTC13_ENST00000366662.4_Silent_p.F468F|TTC13_ENST00000414259.1_Silent_p.F468F	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	521							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TGTTTGGCAGGAAACCAGGTG	0.408000													6	62					0	0	0.001984	0	0
SPEN	23013	broad.mit.edu	37	1	16260533	16260533	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:16260533G>A	ENST00000375759.3	+	11	8002	c.7798G>A	c.(7798-7800)Gag>Aag	p.E2600K		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2600	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACAAGCCTCGGAGGTGCTGGT	0.498000													12	113					0	0	0.001855	0	0
ABCA2	20	broad.mit.edu	37	9	139906446	139906446	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:139906446G>A	ENST00000265662.5	-	35	5532	c.5385C>T	c.(5383-5385)atC>atT	p.I1795I	ABCA2_ENST00000341511.6_Silent_p.I1795I|ABCA2_ENST00000371605.3_Silent_p.I1794I			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1794					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGAAGATGGCGATGACGACAT	0.637000													4	48					0	0	0.009096	0	0
DNMBP	23268	broad.mit.edu	37	10	101657950	101657950	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr10:101657950T>A	ENST00000342239.3	-	9	2904	c.2813A>T	c.(2812-2814)aAt>aTt	p.N938I	DNMBP_ENST00000543621.1_Missense_Mutation_p.N184I|DNMBP_ENST00000540316.1_5'UTR|DNMBP_ENST00000324109.4_Missense_Mutation_p.N938I			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	938	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TGGGGTGGAATTCAGCAACTC	0.438000													11	73					0	0	0.001855	0	0
GADD45GIP1	90480	broad.mit.edu	37	19	13065144	13065144	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:13065144C>T	ENST00000316939.1	-	2	570	c.547G>A	c.(547-549)Gag>Aag	p.E183K		NM_052850.2	NP_443082.2	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma interacting protein 1	183					cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(2)|prostate(1)|skin(1)	4						TCCTTCTTCTCTAGGTCCTGG	0.627000													6	101					0	0	0.001984	0	0
ATP10A	57194	broad.mit.edu	37	15	26026297	26026297	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr15:26026297C>T	ENST00000356865.6	-	2	634	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	175					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.E175K(1)		NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGGAAGATTTCGTTGCAGCGA	0.498000													3	33					0	0	0.004672	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49032203	49032203	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chrX:49032203G>T	ENST00000376317.3	-	9	1761	c.1667C>A	c.(1666-1668)tCa>tAa	p.S556*	PRICKLE3_ENST00000538114.1_Nonsense_Mutation_p.S380*|PRICKLE3_ENST00000540849.1_Nonsense_Mutation_p.S488*|PRICKLE3_ENST00000536904.1_Nonsense_Mutation_p.S475*	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	556	Poly-Ser.						protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						ATCCTCTGATGATTCGGAACT	0.577000													15	75					1.15088e-07	1.28166e-07	0.004007	1	0
PLEKHG4B	153478	broad.mit.edu	37	5	171485	171485	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:171485G>A	ENST00000283426.6	+	14	2958	c.2908G>A	c.(2908-2910)Gcc>Acc	p.A970T		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	970	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GCTCCGAGCCGCCGAGGTCGT	0.677000													4	28					0	0	0.003080	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335745	117335745	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:117335745C>T	ENST00000321322.6	-	17	3359	c.3358G>A	c.(3358-3360)Gcc>Acc	p.A1120T	DSCAML1_ENST00000527706.1_Missense_Mutation_p.A850T	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1060	Fibronectin type-III 3.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCATACTGGGCGAACTTCTTG	0.622000													6	92					0	0	0.001984	0	0
PIK3R1	5295	broad.mit.edu	37	5	67589628	67589628	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:67589628A>T	ENST00000521381.1	+	11	2007	c.1391A>T	c.(1390-1392)gAt>gTt	p.D464V	PIK3R1_ENST00000396611.1_Missense_Mutation_p.D464V|PIK3R1_ENST00000523872.1_Missense_Mutation_p.D101V|PIK3R1_ENST00000274335.5_Missense_Mutation_p.D464V|PIK3R1_ENST00000320694.8_Missense_Mutation_p.D164V|PIK3R1_ENST00000336483.5_Missense_Mutation_p.D194V|PIK3R1_ENST00000521657.1_Missense_Mutation_p.D464V	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	464					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.Y463_L466del(1)|p.E462_R465delEYDR(1)|p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGAGAATATGATAGATTATAT	0.294000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			9	54					0	0	0.000978	0	0
SYNE1	23345	broad.mit.edu	37	6	152722368	152722368	+	Missense_Mutation	SNP	A	A	G	rs138004884	byFrequency	TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:152722368A>G	ENST00000367255.5	-	47	7535	c.6934T>C	c.(6934-6936)Ttt>Ctt	p.F2312L	SYNE1_ENST00000265368.4_Missense_Mutation_p.F2312L|SYNE1_ENST00000341594.5_Missense_Mutation_p.F2349L|SYNE1_ENST00000423061.1_Missense_Mutation_p.F2319L|SYNE1_ENST00000448038.1_Missense_Mutation_p.F2319L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2312					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCATTAATAAACTTCTCCACT	0.393000										HNSCC(10;0.0054)			4	66					0	0	0.009096	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948498	82948498	+	Silent	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:82948498G>T	ENST00000274341.4	-	3	1096	c.246C>A	c.(244-246)acC>acA	p.T82T	HAPLN1_ENST00000514416.1_Silent_p.T82T	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	82	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		AAGTTAGCTTGGTCCACTTAA	0.423000													5	97					1.6384e-10	1.84555e-10	0.001984	1	0
TENC1	23371	broad.mit.edu	37	12	53455639	53455639	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:53455639G>A	ENST00000314250.6	+	22	3779	c.3489G>A	c.(3487-3489)ctG>ctA	p.L1163L	TENC1_ENST00000314276.3_Silent_p.L1173L|TENC1_ENST00000546602.1_Silent_p.L1066L|TENC1_ENST00000552570.1_Silent_p.L1163L|TENC1_ENST00000549700.1_Silent_p.L1098L|TENC1_ENST00000451358.1_Silent_p.L1153L|TENC1_ENST00000379902.3_Silent_p.L1039L	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	1163	SH2.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GGGCCTTCCTGATCAGGGACA	0.617000													12	139					0	0	0.001855	0	0
FAM83G	644815	broad.mit.edu	37	17	18882983	18882983	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:18882983G>T	ENST00000388995.6	-	4	917	c.694C>A	c.(694-696)Ctc>Atc	p.L232I	SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000395647.2_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.L232I|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000317977.6_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.L232I			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	232										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						CGCACTCTGAGATTCTGTTTT	0.587000													6	89					0.00448238	0.00482718	0.004482	1	0
TBC1D32	221322	broad.mit.edu	37	6	121600334	121600334	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:121600334T>C	ENST00000275159.6	-	15	1665	c.1666A>G	c.(1666-1668)Att>Gtt	p.I556V	TBC1D32_ENST00000398212.2_Missense_Mutation_p.I556V					TBC1 domain family, member 32																		ACAGATGCAATTCTTGCCAAA	0.328000													5	59					0	0	0.001168	0	0
KLF11	8462	broad.mit.edu	37	2	10186310	10186310	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:10186310G>A	ENST00000535335.1	+	2	241	c.25G>A	c.(25-27)Gag>Aag	p.E9K	KLF11_ENST00000540845.1_Missense_Mutation_p.E9K|KLF11_ENST00000305883.1_Missense_Mutation_p.E26K	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	26					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GTCCATCCTGGAGAGGAAGCG	0.522000													5	50					0	0	0.000602	0	0
BRWD1	54014	broad.mit.edu	37	21	40568320	40568320	+	Silent	SNP	A	A	G			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:40568320A>G	ENST00000342449.3	-	41	6753	c.6675T>C	c.(6673-6675)taT>taC	p.Y2225Y	BRWD1_ENST00000333229.2_Intron|BRWD1_ENST00000380800.3_Intron	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TAGATTTTGCATAGTCCAAAT	0.383000													7	110					0	0	0.001984	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:21971120G>A	ENST00000304494.5	-	2	508	c.238C>T	c.(238-240)Cga>Tga	p.R80*	CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P135L|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P94L|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R29*|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P94L|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R80*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	80			R -> L (in a head and neck tumor).|R -> P (in CMM2; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R80*(100)|p.?(44)|p.P135L(7)|p.L65fs*38(1)|p.T79fs*37(1)|p.0(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726000	R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)|R80*(MEWO_SKIN)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	11					0	0	0.004482	0	0
COL18A1	80781	broad.mit.edu	37	21	46875807	46875807	+	Silent	SNP	C	C	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:46875807C>T	ENST00000359759.4	+	1	384	c.363C>T	c.(361-363)atC>atT	p.I121I	COL18A1_ENST00000400337.2_Intron|COL18A1_ENST00000355480.5_Silent_p.I121I			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	121					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CCAAAGGCATCCGGAGCTTCG	0.642000													8	80					0	0	0.004482	0	0
ZFHX3	463	broad.mit.edu	37	16	72821618	72821618	+	Silent	SNP	A	A	G	rs112443847		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:72821618A>G	ENST00000268489.5	-	10	11229	c.10557T>C	c.(10555-10557)ggT>ggC	p.G3519G	ZFHX3_ENST00000397992.5_Silent_p.G2605G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3519	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.G3519G(3)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccaccgccgccgc	0.716000													3	15					0	0	0.009096	0	0
MYH13	8735	broad.mit.edu	37	17	10209914	10209914	+	Silent	SNP	T	T	C			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:10209914T>C	ENST00000418404.3	-	36	5491	c.5328A>G	c.(5326-5328)gaA>gaG	p.E1776E	MYH13_ENST00000252172.4_Silent_p.E1776E|MYH13_ENST00000570743.1_Silent_p.E1776E			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1776					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TGGTGTCCTGTTCCTTCTTTA	0.577000													9	96					0	0	0.006214	0	0
VAV1	7409	broad.mit.edu	37	19	6829898	6829898	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:6829898A>T	ENST00000304076.2	+	14	1461	c.1367A>T	c.(1366-1368)gAt>gTt	p.D456V	VAV1_ENST00000602142.1_Missense_Mutation_p.D456V|VAV1_ENST00000596764.1_Missense_Mutation_p.D424V|VAV1_ENST00000539284.1_Missense_Mutation_p.D359V|VAV1_ENST00000599806.1_Missense_Mutation_p.D401V	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	456	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CAGGTTCGGGATGACTCTTCA	0.552000													4	61					0	0	0.009096	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28327420	28327420	+	Silent	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:28327420G>A	ENST00000377255.3	+	3	354	c.57G>A	c.(55-57)caG>caA	p.Q19Q	ZKSCAN3_ENST00000252211.2_Silent_p.Q19Q|ZKSCAN3_ENST00000341464.5_Intron	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	19					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						CAGAAGACCAGATGGAGCTTC	0.562000													9	98					0	0	0.006214	0	0
FAT1	2195	broad.mit.edu	37	4	187542660	187542660	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:187542660G>A	ENST00000441802.2	-	10	5289	c.5080C>T	c.(5080-5082)Caa>Taa	p.Q1694*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1694	Cadherin 15.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ACTGATGATTGACTATGGGCT	0.393000										HNSCC(5;0.00058)			7	49					0	0	0.003080	0	0
CTBS	1486	broad.mit.edu	37	1	85039999	85040007	+	In_Frame_Del	DEL	GCAGCGCCA	GCAGCGCCA	-	rs3217269		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:85039999_85040007delGCAGCGCCA	ENST00000370630.4	-	1	140_148	c.92_100delTGGCGCTGC	c.(91-102)cgg>c	p.LALR31del	CTBS_ENST00000477677.1_5'UTR	NM_004388.2	NP_004379.1	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl-	31						lysosome	cation binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)	9				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		GCCGCGAGCCgcagcgccagcagcgccag	0.718													2	4	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184045767	184045767	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:184045767delG	ENST00000342981.4	+	25	4347	c.3933delG	c.(3931-3933)ctfs	p.L1311fs	EIF4G1_ENST00000441154.1_Frame_Shift_Del_p.L1147fs|EIF4G1_ENST00000435046.2_Frame_Shift_Del_p.L1114fs|EIF4G1_ENST00000411531.1_Frame_Shift_Del_p.L1271fs|EIF4G1_ENST00000319274.6_Frame_Shift_Del_p.L1310fs|EIF4G1_ENST00000392537.2_Frame_Shift_Del_p.L1223fs|EIF4G1_ENST00000346169.2_Frame_Shift_Del_p.L1310fs|EIF4G1_ENST00000424196.1_Frame_Shift_Del_p.L1317fs|EIF4G1_ENST00000434061.2_Frame_Shift_Del_p.L1115fs|EIF4G1_ENST00000382330.3_Frame_Shift_Del_p.L1317fs|EIF4G1_ENST00000352767.3_Frame_Shift_Del_p.L1317fs|EIF4G1_ENST00000414031.1_Frame_Shift_Del_p.L1270fs|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000427845.1_Frame_Shift_Del_p.L1224fs|EIF4G1_ENST00000350481.5_Frame_Shift_Del_p.L1146fs	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1310	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTGGGCATCTGTCTACTGCTC	0.537													7	113	---	---	---	---					
RP11-51O6.1	0	broad.mit.edu	37	16	61089300	61089303	+	RNA	DEL	TTCT	TTCT	-	rs80101907		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:61089300_61089303delTTCT	ENST00000591758.1	-	0	565_566																											TAGCttcttcttcttttttttttt	0.240													6	11	---	---	---	---					
LOC101927755	101927755	broad.mit.edu	37	17	58066608	58066608	+	RNA	DEL	T	T	-			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:58066608delT	ENST00000586209.1	+	0	158																											TTGATTGTGATTTTTTTTTTT	0.313													2	4	---	---	---	---					
