Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HFM1	164045	broad.mit.edu	37	1	91861862	91861862	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:91861862G>A	ENST00000370425.3	-	3	270	c.172C>T	c.(172-174)Cat>Tat	p.H58Y	HFM1_ENST00000370424.3_Intron|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	58							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AACAGTTTATGACTTTCTAAT	0.348000													7	26					0	0	0.248553	0	0
C5orf54	63920	broad.mit.edu	37	5	159821613	159821613	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:159821613C>G	ENST00000408953.3	-	2	1392	c.885G>C	c.(883-885)gtG>gtC	p.V295V	C5orf54_ENST00000523213.1_Silent_p.V295V	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	295										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						ttattaccctcaccacagtaa	0.378000													28	92					0	0	0.750413	0	0
INTS7	25896	broad.mit.edu	37	1	212115325	212115325	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:212115325C>T	ENST00000366994.3	-	20	2834	c.2730G>A	c.(2728-2730)gtG>gtA	p.V910V	INTS7_ENST00000440600.2_Silent_p.V861V|INTS7_ENST00000366993.3_Silent_p.V896V|INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366992.3_Silent_p.V890V	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	910					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TGGCATCTTTCACAGAAGATT	0.403000													28	103					0	0	0.717897	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940335	82940335	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:82940335C>A	ENST00000274341.4	-	4	1472	c.622G>T	c.(622-624)Ggc>Tgc	p.G208C		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	208	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CTGAGCCAGCCGGCATTGCAC	0.622000													46	11					1.41504e-22	1.62004e-22	0.859065	1	0
MARCO	8685	broad.mit.edu	37	2	119727757	119727757	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:119727757G>C	ENST00000541757.1	+	4	413	c.33G>C	c.(31-33)gaG>gaC	p.E11D	MARCO_ENST00000327097.4_Missense_Mutation_p.E89D			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	89					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						TGGCGGCTGAGGACAGCCCGT	0.607000													22	32					0	0	0.639603	0	0
LFNG	3955	broad.mit.edu	37	7	2566545	2566545	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:2566545G>A	ENST00000222725.5	+	7	1083	c.1063G>A	c.(1063-1065)Gac>Aac	p.D355N	LFNG_ENST00000338732.3_Missense_Mutation_p.D226N|LFNG_ENST00000402045.1_Missense_Mutation_p.D226N|LFNG_ENST00000359574.3_Missense_Mutation_p.D355N|LFNG_ENST00000402506.1_Missense_Mutation_p.D284N	NM_001040167.1	NP_001035257.1	Q8NES3	LFNG_HUMAN	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	355					organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)|urinary_tract(2)	6		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		GGTGGAGGCCGACCCATCCAG	0.647000													5	17					0	0	0.217242	0	0
GPR61	83873	broad.mit.edu	37	1	110086037	110086037	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:110086037C>G	ENST00000527748.1	+	2	1076	c.393C>G	c.(391-393)ctC>ctG	p.L131L	RP5-1160K1.8_ENST00000526411.1_RNA	NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	131						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGGCCATCCTCTCGGTGTCAG	0.607000													22	92					0	0	0.654019	0	0
COL4A3	1285	broad.mit.edu	37	2	228131135	228131135	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:228131135G>A	ENST00000396578.3	+	22	1480	c.1318G>A	c.(1318-1320)Gac>Aac	p.D440N	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	440	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TTTTATAGGTGACATCGTTTT	0.393000													3	33					0	0	0.115264	0	0
ROBO1	6091	broad.mit.edu	37	3	79067568	79067568	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:79067568C>G	ENST00000436010.2	-	1	1041	c.44G>C	c.(43-45)tGt>tCt	p.C15S	ROBO1_ENST00000464233.1_Intron|ROBO1_ENST00000495273.1_Missense_Mutation_p.C15S|ROBO1_ENST00000467549.1_Missense_Mutation_p.C15S			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGAACAGAGACATATTAATCC	0.498000													10	7					0	0	0.411799	0	0
CCDC40	55036	broad.mit.edu	37	17	78032313	78032313	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:78032313A>G	ENST00000397545.4	+	8	1207	c.1180A>G	c.(1180-1182)Atg>Gtg	p.M394V	CCDC40_ENST00000374876.4_Missense_Mutation_p.M394V|CCDC40_ENST00000374877.3_Missense_Mutation_p.M394V|CCDC40_ENST00000269318.5_Missense_Mutation_p.M394V	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	394					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCAGACTGAGATGGAGAACTT	0.602000													8	37					0	0	0.278610	0	0
SERAC1	84947	broad.mit.edu	37	6	158540196	158540196	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:158540196G>A	ENST00000367102.2	-	12	1314	c.1173C>T	c.(1171-1173)ccC>ccT	p.P391P	SERAC1_ENST00000367101.1_Silent_p.P391P|SERAC1_ENST00000367104.3_Silent_p.P391P			Q96JX3	SRAC1_HUMAN	serine active site containing 1	391					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CTGCTTTAATGGGCTGACTAA	0.423000													2	5					0	0	0.115264	0	0
DPY19L2	283417	broad.mit.edu	37	12	64055144	64055144	+	Missense_Mutation	SNP	G	G	A	rs140337663		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:64055144G>A	ENST00000324472.4	-	4	751	c.568C>T	c.(568-570)Cgc>Tgc	p.R190C	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	190					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AGATGGAAGCGTTTTATTGCA	0.333000													21	69					0	0	0.624587	0	0
RBFOX1	54715	broad.mit.edu	37	16	7703928	7703928	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:7703928C>A	ENST00000340209.4	+	9	1181	c.884C>A	c.(883-885)cCc>cAc	p.P295H	RBFOX1_ENST00000550418.1_Missense_Mutation_p.P290H|RBFOX1_ENST00000535565.2_Missense_Mutation_p.P247H|RBFOX1_ENST00000547372.1_Missense_Mutation_p.P333H|RBFOX1_ENST00000547338.1_Missense_Mutation_p.P290H|RBFOX1_ENST00000552089.1_Missense_Mutation_p.P307H|RBFOX1_ENST00000553186.1_Missense_Mutation_p.P263H|RBFOX1_ENST00000436368.2_Missense_Mutation_p.P310H|RBFOX1_ENST00000422070.4_Missense_Mutation_p.P333H|RBFOX1_ENST00000355637.4_Missense_Mutation_p.P310H|RBFOX1_ENST00000311745.5_Missense_Mutation_p.P310H			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	290					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						gcgcccccgcccccgATCCCG	0.746000													6	6					0.217242	0.218592	0.217242	1	0
RLF	6018	broad.mit.edu	37	1	40701683	40701683	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:40701683G>C	ENST00000372771.4	+	8	1336	c.1309G>C	c.(1309-1311)Gat>Cat	p.D437H		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	437					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TTTGCAACCAGATCAAAAATT	0.368000													23	111					0	0	0.624587	0	0
NR2F2	7026	broad.mit.edu	37	15	96875642	96875642	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:96875642T>G	ENST00000394166.3	+	1	1697	c.308T>G	c.(307-309)tTc>tGc	p.F103C	NR2F2_ENST00000421109.2_Intron	NM_021005.3	NP_066285.1	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	103					lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(2)|lung(3)|ovary(2)|urinary_tract(1)	17	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			AAGAGCTTCTTCAAGCGCAGC	0.622000													6	11					0	0	0.217242	0	0
SSRP1	6749	broad.mit.edu	37	11	57100270	57100270	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:57100270G>A	ENST00000278412.2	-	6	863	c.597C>T	c.(595-597)atC>atT	p.I199I		NM_003146.2	NP_003137.1	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	199					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(4)	23						GGAAGATGCAGATGGCATCTC	0.537000													8	32					0	0	0.278610	0	0
NCOR1	9611	broad.mit.edu	37	17	16068406	16068406	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:16068406G>C	ENST00000268712.3	-	5	762	c.505C>G	c.(505-507)Caa>Gaa	p.Q169E	NCOR1_ENST00000395848.1_Missense_Mutation_p.Q60E|NCOR1_ENST00000395851.1_Missense_Mutation_p.Q169E	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	169	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GAAGCATTTTGATCATCTCCA	0.393000													10	76					0	0	0.361761	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68703947	68703947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:68703947G>A	ENST00000283916.6	-	5	516	c.418C>T	c.(418-420)Cga>Tga	p.R140*	TMPRSS11D_ENST00000545541.1_Nonsense_Mutation_p.R23*|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11D_ENST00000509584.1_5'UTR	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	140	SEA.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						AGCATTTGTCGTAAAACAGAC	0.333000													19	31					0	0	0.575678	0	0
ZNF334	55713	broad.mit.edu	37	20	45140723	45140723	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:45140723G>T	ENST00000347606.4	-	2	201	c.19C>A	c.(19-21)Cag>Aag	p.Q7K	ZNF334_ENST00000457685.2_5'UTR	NM_018102.4	NP_060572.3	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				CAACTTACCTGAAATTTTTTC	0.378000													20	26					7.87624e-14	8.83011e-14	0.639603	1	0
LPCAT1	79888	broad.mit.edu	37	5	1489929	1489929	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:1489929G>A	ENST00000283415.3	-	4	670	c.538C>T	c.(538-540)Cag>Tag	p.Q180*		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	180					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		CGAGAATCCTGGTCTGACCGG	0.557000													20	479					0	0	0.557998	0	0
BRAP	8315	broad.mit.edu	37	12	112097072	112097072	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:112097072C>T	ENST00000419234.4	-	8	1243	c.1050G>A	c.(1048-1050)gaG>gaA	p.E350E	BRAP_ENST00000327551.6_Silent_p.E320E|BRAP_ENST00000539060.1_Silent_p.E171E	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	350					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						GCTGCGTTTCCTCAAAGTGCT	0.448000													9	69					0	0	0.361761	0	0
DNAH2	146754	broad.mit.edu	37	17	7736073	7736073	+	Splice_Site	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:7736073C>T	ENST00000572933.1	+	83	14363	c.12903_splice	c.e83+1	p.N4301_splice	DNAH2_ENST00000389173.2_Splice_Site_p.N4301_splice			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	4301					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCCAAAACAACGTGAGCAATG	0.557000													172	43					0	0	0.870114	0	0
SUGP1	57794	broad.mit.edu	37	19	19431288	19431288	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:19431288G>A	ENST00000247001.5	-	1	365	c.18C>T	c.(16-18)gaC>gaT	p.D6D	SUGP1_ENST00000334782.5_Silent_p.D6D|SUGP1_ENST00000585763.1_5'UTR	NM_172231.3	NP_757386.2	Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	6					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						CATCCCGGTTGTCCATCTTGA	0.632000													24	41					0	0	0.681144	0	0
TNS3	64759	broad.mit.edu	37	7	47476871	47476871	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:47476871A>G	ENST00000398879.1	-	7	557	c.191T>C	c.(190-192)cTt>cCt	p.L64P	TNS3_ENST00000442536.2_Missense_Mutation_p.L64P|TNS3_ENST00000355730.3_Missense_Mutation_p.L64P|TNS3_ENST00000311160.9_Missense_Mutation_p.L64P|TNS3_ENST00000458317.2_Missense_Mutation_p.L64P			Q68CZ2	TENS3_HUMAN	tensin 3	64	Phosphatase tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CTTTGGGTTAAGCTTCGTAAG	0.279000													21	32					0	0	0.654019	0	0
LAMA5	3911	broad.mit.edu	37	20	60884793	60884793	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:60884793G>C	ENST00000252999.3	-	79	10993	c.10927C>G	c.(10927-10929)Ctg>Gtg	p.L3643V		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3643	Laminin G-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGAGGTACAGAGGGGCTGGG	0.672000													10	12					0	0	0.387290	0	0
KCNB1	3745	broad.mit.edu	37	20	47990164	47990164	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:47990164C>G	ENST00000371741.4	-	2	2099	c.1933G>C	c.(1933-1935)Gat>Cat	p.D645H		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	645					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGGCTGGCATCAGGGCTGGGG	0.567000													7	57					0	0	0.248553	0	0
RAPH1	65059	broad.mit.edu	37	2	204306102	204306102	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:204306102G>A	ENST00000319170.5	-	14	2110	c.1811C>T	c.(1810-1812)tCa>tTa	p.S604L	RAPH1_ENST00000374493.3_Missense_Mutation_p.S656L|RAPH1_ENST00000457812.1_Intron	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	604					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GGGCACAAGTGAAGTGTAGGG	0.502000													4	17					0	0	0.217242	0	0
THSD7A	221981	broad.mit.edu	37	7	11676325	11676325	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:11676325C>T	ENST00000423059.3	-	2	705	c.454G>A	c.(454-456)Ggt>Agt	p.G152S	THSD7A_ENST00000480061.1_5'UTR	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	152						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACCTGAATACCTTCTTCCCCC	0.488000										HNSCC(18;0.044)			16	26					0	0	0.500413	0	0
TTN	7273	broad.mit.edu	37	2	179482556	179482556	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179482556A>T	ENST00000589042.1	-	253	47746	c.47522T>A	c.(47521-47523)gTt>gAt	p.V15841D	TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V6901D|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V14200D|TTN_ENST00000460472.2_Missense_Mutation_p.V6776D|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V6968D|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V13273D	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14200	Fibronectin type-III 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTTTTCCAACTCCAATTCG	0.443000													45	75					0	0	0.859065	0	0
AGO1	26523	broad.mit.edu	37	1	36367909	36367909	+	Silent	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:36367909C>A	ENST00000373204.4	+	11	1581	c.1368C>A	c.(1366-1368)ccC>ccA	p.P456P	AGO1_ENST00000373206.1_Silent_p.P381P	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GCTTCGCACCCCAAAAACAGT	0.572000													20	53					1.15919e-05	1.21546e-05	0.575678	1	0
ENY2	56943	broad.mit.edu	37	8	110348368	110348368	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:110348368G>A	ENST00000521688.1	+	2	163	c.18G>A	c.(16-18)atG>atA	p.M6I	ENY2_ENST00000522407.1_Intron|ENY2_ENST00000521662.1_Start_Codon_SNP_p.M1I|ENY2_ENST00000520147.1_Start_Codon_SNP_p.M1I	NM_001193557.1|NM_020189.5	NP_001180486.1|NP_064574.1	Q9NPA8	ENY2_HUMAN	enhancer of yellow 2 homolog (Drosophila)	6					histone deubiquitination|mRNA transport|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity			endometrium(2)|large_intestine(1)|lung(1)	4	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;9.05e-13)			TTAGCAAGATGAACAAAGATG	0.358000													8	13					0	0	0.361761	0	0
CILP	8483	broad.mit.edu	37	15	65490839	65490839	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:65490839T>C	ENST00000261883.4	-	9	1951	c.1785A>G	c.(1783-1785)gaA>gaG	p.E595E		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	595					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						CCATGGGGTCTTCACCAACCA	0.522000													29	57					0	0	0.740014	0	0
TTN	7273	broad.mit.edu	37	2	179430407	179430407	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179430407C>T	ENST00000589042.1	-	326	80676	c.80452G>A	c.(80452-80454)Gaa>Aaa	p.E26818K	TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E17878K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E25177K|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E17753K|TTN_ENST00000342175.6_Missense_Mutation_p.E17945K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E24250K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25177	Fibronectin type-III 95.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTGCATTTCAACAACGTAC	0.453000													21	131					0	0	0.608945	0	0
DNM1P46	196968	broad.mit.edu	37	15	100341321	100341321	+	RNA	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:100341321G>A	ENST00000341853.1	-	0	325					NR_003260.1																						TCCATTTGCCGCTCCAGCTGT	0.582000													4	49					0	0	0.361761	0	0
TRIM54	57159	broad.mit.edu	37	2	27528452	27528452	+	Splice_Site	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:27528452G>T	ENST00000296098.4	+	6	1006	c.735_splice	c.e6-1	p.D246_splice	TRIM54_ENST00000380075.2_Splice_Site_p.D204_splice	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	204					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATCTTTTAGGACAATAGCCG	0.582000													4	12					0.184627	0.186935	0.184627	1	0
ZNF385B	151126	broad.mit.edu	37	2	180348156	180348156	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:180348156C>A	ENST00000410066.1	-	6	1116	c.513G>T	c.(511-513)caG>caT	p.Q171H	ZNF385B_ENST00000466398.1_5'UTR|ZNF385B_ENST00000409692.1_Missense_Mutation_p.Q69H|ZNF385B_ENST00000409343.1_Missense_Mutation_p.Q95H|ZNF385B_ENST00000336917.5_Missense_Mutation_p.Q69H	NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	171						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GGGCCTCGGCCTGGCTCTACA	0.428000													30	34					2.80507e-11	3.06008e-11	0.760397	1	0
MICAL3	57553	broad.mit.edu	37	22	18387600	18387600	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18387600G>A	ENST00000441493.2	-	3	622	c.270C>T	c.(268-270)ctC>ctT	p.L90L	MICAL3_ENST00000207726.7_Silent_p.L90L|MICAL3_ENST00000383094.3_Silent_p.L90L|MICAL3_ENST00000585038.1_Silent_p.L90L|MICAL3_ENST00000429452.1_Silent_p.L90L|MICAL3_ENST00000444520.1_Silent_p.L90L|MICAL3_ENST00000414725.2_Silent_p.L90L|MICAL3_ENST00000400561.2_Silent_p.L90L	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	90						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CCCCAATGATGAGACACTGAA	0.507000													4	20					0	0	0.150653	0	0
KIAA0947	23379	broad.mit.edu	37	5	5463028	5463028	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:5463028C>G	ENST00000296564.7	+	13	3803	c.3581C>G	c.(3580-3582)tCt>tGt	p.S1194C		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1194										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						GACTCTGTTTCTGAATGTTCT	0.378000													6	41					0	0	0.217242	0	0
ATP11A	23250	broad.mit.edu	37	13	113464990	113464990	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:113464990C>A	ENST00000487903.1	+	5	479	c.391C>A	c.(391-393)Cat>Aat	p.H131N	ATP11A_ENST00000375630.2_Missense_Mutation_p.H131N|ATP11A_ENST00000375645.3_Missense_Mutation_p.H131N|ATP11A_ENST00000283558.8_Missense_Mutation_p.H131N			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	131					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GTGTCCTGTTCATTTCATTCA	0.463000													18	124					8.00594e-06	8.44927e-06	0.557998	1	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	66					0	0	0.150653	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092296	151092296	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:151092296G>A	ENST00000360243.2	+	3	427	c.160G>A	c.(160-162)Gtg>Atg	p.V54M	MAGEA4_ENST00000276344.2_Missense_Mutation_p.V54M|MAGEA4_ENST00000393921.1_Missense_Mutation_p.V54M|MAGEA4_ENST00000370335.1_Missense_Mutation_p.V54M|MAGEA4_ENST00000370337.4_Missense_Mutation_p.V54M|MAGEA4_ENST00000393920.1_Missense_Mutation_p.V54M|MAGEA4_ENST00000370340.3_Missense_Mutation_p.V54M	NM_001011550.1	NP_001011550.1	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	54							protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGAGGAAGTGCCTGCTGC	0.627000													40	10					0	0	0.819951	0	0
KRT6A	3853	broad.mit.edu	37	12	52884660	52884660	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:52884660C>T	ENST00000330722.6	-	4	962	c.894G>A	c.(892-894)ctG>ctA	p.L298L		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	298	Coil 1B.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACAAGGCTCTCAGGAAGTTGA	0.488000													13	79					0	0	0.411799	0	0
FAM110B	90362	broad.mit.edu	37	8	59059795	59059795	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:59059795G>A	ENST00000361488.3	+	5	1886	c.1006G>A	c.(1006-1008)Gac>Aac	p.D336N	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	336						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CAGTGCCAATGACCGCGTGCC	0.458000													12	13					0	0	0.387290	0	0
HDAC3	8841	broad.mit.edu	37	5	141009429	141009429	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:141009429C>T	ENST00000305264.3	-	5	497	c.418G>A	c.(418-420)Gag>Aag	p.E140K		NM_003883.3	NP_003874.2	O15379	HDAC3_HUMAN	histone deacetylase 3	140	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	TCACTCACCTCAAACTTCTTG	0.517000													9	50					0	0	0.335167	0	0
MCM4	4173	broad.mit.edu	37	8	48887407	48887407	+	Silent	SNP	T	T	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:48887407T>A	ENST00000262105.2	+	14	2459	c.2250T>A	c.(2248-2250)tcT>tcA	p.S750S	MCM4_ENST00000523944.1_Silent_p.S750S	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	750					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TAAGATTGTCTAACAAAGTTG	0.498000													12	159					0	0	0.411799	0	0
ZNF10	7556	broad.mit.edu	37	12	133732548	133732548	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:133732548A>T	ENST00000248211.6	+	5	938	c.716A>T	c.(715-717)aAa>aTa	p.K239I	ZNF10_ENST00000402932.2_Intron|ZNF10_ENST00000426665.2_Missense_Mutation_p.K239I|CTD-2140B24.4_ENST00000540096.2_Intron|ZNF268_ENST00000416488.1_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	239				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AAATCCTACAAATGCCCTGAT	0.373000													27	48					0	0	0.667858	0	0
MYO15A	51168	broad.mit.edu	37	17	18062990	18062990	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:18062990G>A	ENST00000205890.5	+	55	9638	c.9300G>A	c.(9298-9300)ctG>ctA	p.L3100L	MYO15A_ENST00000451725.2_5'UTR|MYO15A_ENST00000418233.3_Silent_p.L364L	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	3100	MyTH4 2.|Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GTAACCTCCTGAAGGTCAGTC	0.532000													8	28					0	0	0.278610	0	0
CLK3	1198	broad.mit.edu	37	15	74922109	74922109	+	Nonsense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:74922109T>G	ENST00000395066.3	+	13	2263	c.1802T>G	c.(1801-1803)tTa>tGa	p.L601*	CLK3_ENST00000352989.5_Nonsense_Mutation_p.L430*|CLK3_ENST00000348245.3_3'UTR|CLK3_ENST00000345005.4_Nonsense_Mutation_p.L453*	NM_001130028.1	NP_001123500.1	P49761	CLK3_HUMAN	CDC-like kinase 3	601	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)|stomach(2)|urinary_tract(1)	15						AGGAGGATGTTAGAATTTGAC	0.607000													22	5					0	0	0.639603	0	0
ZNF80	7634	broad.mit.edu	37	3	113955700	113955700	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:113955700C>T	ENST00000482457.2	-	1	725	c.222G>A	c.(220-222)gtG>gtA	p.V74V		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	74						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CATAAGGCTTCACCCCAGTGT	0.498000													8	23					0	0	0.278610	0	0
TMSB4Y	9087	broad.mit.edu	37	Y	15816245	15816245	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrY:15816245C>G	ENST00000284856.3	+	1	799	c.30C>G	c.(28-30)atC>atG	p.I10M		NM_004202.2	NP_004193.1	O14604	TYB4Y_HUMAN	thymosin beta 4, Y-linked	10					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding										TGGCTGAGATCGAGAAATTCG	0.483000													4	5					0	0	0.184627	0	0
ZNF513	130557	broad.mit.edu	37	2	27600461	27600461	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:27600461G>T	ENST00000323703.6	-	4	1775	c.1577C>A	c.(1576-1578)cCa>cAa	p.P526Q	ZNF513_ENST00000407879.1_Missense_Mutation_p.P464Q	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	526					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCAGGGCTGGTGGGCCCCG	0.622000													32	61					6.90743e-12	7.63825e-12	0.788014	1	0
MLH3	27030	broad.mit.edu	37	14	75485569	75485569	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:75485569G>T	ENST00000355774.2	-	12	4420	c.4205C>A	c.(4204-4206)cCg>cAg	p.P1402Q	MLH3_ENST00000380968.2_Missense_Mutation_p.P340Q|MLH3_ENST00000238662.7_Missense_Mutation_p.P1378Q|MLH3_ENST00000556740.1_Missense_Mutation_p.P1402Q|MLH3_ENST00000556257.1_Missense_Mutation_p.P1224Q	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	1402					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding	p.P1378R(1)		breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		GTCAGCTAACGGCAGCATAGA	0.468000								Mismatch excision repair (MMR)					25	38					6.12954e-19	6.94395e-19	0.681144	1	0
TTC40	54777	broad.mit.edu	37	10	134628237	134628237	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:134628237C>A	ENST00000368586.5	-	52	7302	c.7202G>T	c.(7201-7203)cGg>cTg	p.R2401L	TTC40_ENST00000263170.5_Missense_Mutation_p.R562L	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	562										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						GGGGATGGTCCGGGGGATGCT	0.657000													17	27					1.33834e-09	1.4454e-09	0.557998	1	0
ITPKB	3707	broad.mit.edu	37	1	226925078	226925078	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:226925078G>A	ENST00000429204.1	-	2	409	c.82C>T	c.(82-84)Ccc>Tcc	p.P28S	ITPKB_ENST00000366784.1_Missense_Mutation_p.P28S|ITPKB_ENST00000272117.3_Missense_Mutation_p.P28S	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	28							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				CTGCCACTGGGCCCCGGGCCG	0.672000													9	11					0	0	0.307466	0	0
SLC12A6	9990	broad.mit.edu	37	15	34538068	34538068	+	Splice_Site	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:34538068C>A	ENST00000354181.3	-	14	2142	c.1649_splice	c.e14-1	p.K550_splice	SLC12A6_ENST00000290209.5_Splice_Site_p.K499_splice|SLC12A6_ENST00000560164.1_Splice_Site_p.K362_splice|SLC12A6_ENST00000451844.2_Splice_Site_p.K362_splice|SLC12A6_ENST00000558667.1_Splice_Site_p.K550_splice|SLC12A6_ENST00000558589.1_Splice_Site_p.K541_splice|SLC12A6_ENST00000397707.2_Splice_Site_p.K535_splice|SLC12A6_ENST00000458406.2_Splice_Site_p.K491_splice|SLC12A6_ENST00000397702.2_Splice_Site_p.K491_splice|SLC12A6_ENST00000560611.1_Splice_Site_p.K550_splice			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	550					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CATCACCGAACCTGGGAAAGA	0.413000													7	13					0.00198382	0.0020405	0.248553	1	0
SLC26A5	375611	broad.mit.edu	37	7	103053458	103053458	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:103053458T>G	ENST00000306312.3	-	5	655	c.394A>C	c.(394-396)Ata>Cta	p.I132L	SLC26A5_ENST00000432958.2_Missense_Mutation_p.I132L|SLC26A5_ENST00000393729.1_Intron|SLC26A5_ENST00000393735.2_Missense_Mutation_p.I132L|SLC26A5_ENST00000393727.1_Missense_Mutation_p.I132L|SLC26A5_ENST00000356767.4_Missense_Mutation_p.I132L|SLC26A5_ENST00000339444.6_Missense_Mutation_p.I132L|SLC26A5_ENST00000393730.1_Missense_Mutation_p.I132L|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393723.1_Missense_Mutation_p.I132L	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	132					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CCTATGGATATGTGTCTGGAG	0.373000													12	42					0	0	0.435327	0	0
ST3GAL4	6484	broad.mit.edu	37	11	126276890	126276890	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:126276890G>A	ENST00000526727.1	+	3	528	c.154G>A	c.(154-156)Gag>Aag	p.E52K	ST3GAL4_ENST00000356132.4_Missense_Mutation_p.E52K|ST3GAL4_ENST00000227495.6_Missense_Mutation_p.E48K|ST3GAL4_ENST00000530591.1_Missense_Mutation_p.E48K|ST3GAL4_ENST00000392669.2_Missense_Mutation_p.E52K|ST3GAL4_ENST00000534457.1_Missense_Mutation_p.E47K|ST3GAL4_ENST00000534083.1_Missense_Mutation_p.E52K|ST3GAL4_ENST00000532243.1_Missense_Mutation_p.E51K|ST3GAL4_ENST00000526756.1_3'UTR|ST3GAL4_ENST00000444328.2_Missense_Mutation_p.E52K|ST3GAL4_ENST00000449406.2_Missense_Mutation_p.E41K			Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	52					post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		GGGTGAGGCAGAGAGCAAGGC	0.542000													15	49					0	0	0.479597	0	0
E4F1	1877	broad.mit.edu	37	16	2273707	2273707	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:2273707G>A	ENST00000301727.4	+	1	141	c.93G>A	c.(91-93)gcG>gcA	p.A31A	E4F1_ENST00000565090.1_Silent_p.A31A|E4F1_ENST00000564139.1_Silent_p.A31A	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	31					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GTGCAGTTGCGGCGGTGGCGG	0.751000													7	2					0	0	0.307466	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222091	140222091	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:140222091C>G	ENST00000531613.1	+	1	1185	c.1185C>G	c.(1183-1185)ttC>ttG	p.F395L	PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.F395L|PCDHA1_ENST00000504120.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTCCCCTTCAAGCTGGTGT	0.577000													43	192					0	0	0.853193	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	64					0	0	0.150653	0	0
RANBP3L	202151	broad.mit.edu	37	5	36251436	36251436	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:36251436G>T	ENST00000296604.3	-	13	1818	c.1333C>A	c.(1333-1335)Caa>Aaa	p.Q445K	RANBP3L_ENST00000502994.1_Missense_Mutation_p.Q470K	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	445					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TTAGTGACTTGGATGAAATCA	0.353000													4	106					8.12818e-05	8.46795e-05	0.248553	1	0
FBN1	2200	broad.mit.edu	37	15	48892392	48892392	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:48892392C>T	ENST00000316623.5	-	5	841	c.386G>A	c.(385-387)tGc>tAc	p.C129Y		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	129	EGF-like 2.		C -> Y (in MFS; severe neonatal).		heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATCGTCACTGCAGCTACCTCC	0.378000													52	21					0	0	0.870114	0	0
DPP3	10072	broad.mit.edu	37	11	66272197	66272197	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:66272197C>T	ENST00000532677.1	+	17	2451	c.2050C>T	c.(2050-2052)Cgt>Tgt	p.R684C	DPP3_ENST00000541961.1_Missense_Mutation_p.R665C|DPP3_ENST00000531863.1_Missense_Mutation_p.R685C|DPP3_ENST00000453114.1_Missense_Mutation_p.R665C|DPP3_ENST00000530165.1_Missense_Mutation_p.R635C|DPP3_ENST00000360510.2_Missense_Mutation_p.R665C	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	665					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						GGTGCTGCTGCGTAAGGAATC	0.592000													19	71					0	0	0.592651	0	0
RASSF5	83593	broad.mit.edu	37	1	206760273	206760273	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:206760273A>G	ENST00000304534.8	+	5	1170	c.761A>G	c.(760-762)gAg>gGg	p.E254G	EIF2D_ENST00000472709.2_Intron|RASSF5_ENST00000367117.3_3'UTR|RASSF5_ENST00000491368.1_3'UTR|RASSF5_ENST00000338603.2_Intron|RASSF5_ENST00000355294.4_Missense_Mutation_p.E407G	NM_182665.2	NP_872606.1	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family member 5	407					apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	8	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGAAACTGGAGGAGGCCTTA	0.418000													3	49					0	0	0.115264	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887747	47887747	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:47887747C>T	ENST00000396105.1	-	3	848	c.602G>A	c.(601-603)cGc>cAc	p.R201H	ZNFX1_ENST00000371754.4_Missense_Mutation_p.R201H|ZNFX1_ENST00000371752.1_Missense_Mutation_p.R201H	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	201							metal ion binding	p.R201H(2)		cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AACACTCTGGCGATCCATTTT	0.453000													57	65					0	0	0.870114	0	0
LRP1B	53353	broad.mit.edu	37	2	141598641	141598641	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:141598641G>A	ENST00000389484.3	-	30	5931	c.4960C>T	c.(4960-4962)Cta>Tta	p.L1654L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1654					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCACTGCTAGCCCTCTGATA	0.368000										TSP Lung(27;0.18)			27	45					0	0	0.729181	0	0
TMEM109	79073	broad.mit.edu	37	11	60689394	60689394	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:60689394G>C	ENST00000227525.3	+	4	892	c.489G>C	c.(487-489)ctG>ctC	p.L163L	TMEM109_ENST00000536171.1_Silent_p.L163L|RP11-881M11.4_ENST00000543907.1_RNA	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	163						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						TGTGGGGCCTGAAGCTTGTCA	0.652000													25	88					0	0	0.693898	0	0
PNPLA8	50640	broad.mit.edu	37	7	108154982	108154982	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:108154982C>G	ENST00000426128.2	-	2	1079	c.954G>C	c.(952-954)aaG>aaC	p.K318N	PNPLA8_ENST00000388728.5_Missense_Mutation_p.K318N|PNPLA8_ENST00000422087.1_Missense_Mutation_p.K318N|PNPLA8_ENST00000436062.1_Missense_Mutation_p.K318N|PNPLA8_ENST00000453144.1_Missense_Mutation_p.K218N|PNPLA8_ENST00000257694.8_Missense_Mutation_p.K318N|PNPLA8_ENST00000483879.1_Intron	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	318					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						CTGACTGACTCTTTGAATCAT	0.413000													30	156					0	0	0.717897	0	0
ELP4	26610	broad.mit.edu	37	11	31625408	31625408	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:31625408T>G	ENST00000395934.2	+	5	614	c.607T>G	c.(607-609)Ttt>Gtt	p.F203V	ELP4_ENST00000350638.5_Missense_Mutation_p.F203V|ELP4_ENST00000379163.5_Missense_Mutation_p.F204V			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	203					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					TTGGCATGGATTTTTTCTTCC	0.328000													21	58					0	0	0.608945	0	0
AGO1	26523	broad.mit.edu	37	1	36367908	36367908	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:36367908C>T	ENST00000373204.4	+	11	1580	c.1367C>T	c.(1366-1368)cCc>cTc	p.P456L	AGO1_ENST00000373206.1_Missense_Mutation_p.P381L	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		TGCTTCGCACCCCAAAAACAG	0.572000													20	53					0	0	0.575678	0	0
PAK1IP1	55003	broad.mit.edu	37	6	10707670	10707670	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:10707670G>C	ENST00000379568.3	+	8	1054	c.763G>C	c.(763-765)Gaa>Caa	p.E255Q		NM_017906.2	NP_060376.2	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	255					negative regulation of signal transduction	nucleolus|plasma membrane				kidney(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				GTTCAGTTTTGAAATTCCAGA	0.333000													22	90					0	0	0.681144	0	0
DNAH11	8701	broad.mit.edu	37	7	21678648	21678648	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:21678648C>G	ENST00000328843.6	+	28	4955	c.4924C>G	c.(4924-4926)Ctt>Gtt	p.L1642V	DNAH11_ENST00000409508.3_Missense_Mutation_p.L1637V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1642	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGCTGATTTACTTGACATTCT	0.398000									Kartagener syndrome				9	48					0	0	0.307466	0	0
EIF4E2	9470	broad.mit.edu	37	2	233431923	233431923	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:233431923A>G	ENST00000409167.3	+	5	565	c.529A>G	c.(529-531)Aag>Gag	p.K177E	EIF4E2_ENST00000409098.1_Splice_Site_p.K222_splice|EIF4E2_ENST00000409495.1_Missense_Mutation_p.K222E|EIF4E2_ENST00000409322.1_Splice_Site_p.K177_splice|EIF4E2_ENST00000409514.1_Splice_Site_p.K222_splice|EIF4E2_ENST00000258416.3_Splice_Site_p.K222_splice|EIF4E2_ENST00000409394.1_Splice_Site_p.K177_splice			O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E family member 2	222	7-methylguanosine-containing mRNA cap binding.				regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	8		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CGACAGCATCAAGTACGTGTT	0.507000													3	103					0	0	0.115264	0	0
DARC	2532	broad.mit.edu	37	1	159174732	159174732	+	Translation_Start_Site	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:159174732C>A	ENST00000537147.1	+	0	826				DARC_ENST00000368122.2_De_novo_Start_OutOfFrame			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor						defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					TGTCTGCGGGCCTGAACCAAA	0.602000													25	53					3.73808e-20	4.26457e-20	0.693898	1	0
OR6N1	128372	broad.mit.edu	37	1	158736156	158736156	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:158736156G>T	ENST00000335094.2	-	1	336	c.317C>A	c.(316-318)tCc>tAc	p.S106Y		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					CGCTCCAAGGGAGTGAAAGAA	0.502000													12	34					5.50884e-06	5.83289e-06	0.411799	1	0
STAT1	6772	broad.mit.edu	37	2	191872313	191872313	+	Silent	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:191872313C>A	ENST00000361099.3	-	5	735	c.348G>T	c.(346-348)ctG>ctT	p.L116L	STAT1_ENST00000409465.1_Silent_p.L116L|STAT1_ENST00000392322.3_Silent_p.L116L|STAT1_ENST00000392323.2_Silent_p.L118L|STAT1_ENST00000540176.1_Silent_p.L116L	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	116					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GGGCGTTTTCCAGAATTTTCC	0.328000													38	44					2.19358e-23	2.52028e-23	0.812448	1	0
DNM1L	10059	broad.mit.edu	37	12	32890803	32890803	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:32890803C>G	ENST00000381000.4	+	16	1681	c.1640C>G	c.(1639-1641)tCt>tGt	p.S547C	DNM1L_ENST00000553257.1_Missense_Mutation_p.S547C|DNM1L_ENST00000358214.5_Intron|DNM1L_ENST00000266481.6_Intron|DNM1L_ENST00000414834.2_Missense_Mutation_p.S331C|DNM1L_ENST00000547312.1_Missense_Mutation_p.S534C|YARS2_ENST00000551673.1_Intron|DNM1L_ENST00000452533.2_Intron|DNM1L_ENST00000549701.1_Missense_Mutation_p.S534C	NM_001278463.1|NM_001278465.1	NP_001265392.1|NP_001265394.1	O00429	DNM1L_HUMAN	dynamin 1-like	534	B domain.|Interaction with GSK3B.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	23	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTTTAGTCTTCTAAAGTTCCA	0.433000													10	39					0	0	0.361761	0	0
ST13	6767	broad.mit.edu	37	22	41240914	41240914	+	Splice_Site	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:41240914C>T	ENST00000216218.3	-	4	726		c.e4-1			NM_003932.3	NP_003923.2	P50502	F10A1_HUMAN	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)								protein binding, bridging			cervix(1)|large_intestine(1)|lung(3)|skin(1)	6						TTATCAATTTCTGCCAAAGTC	0.388000													6	15					0	0	0.278610	0	0
ZNF202	7753	broad.mit.edu	37	11	123601372	123601372	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:123601372C>T	ENST00000336139.4	-	3	587	c.225G>A	c.(223-225)ctG>ctA	p.L75L	ZNF202_ENST00000530393.1_Silent_p.L75L|ZNF202_ENST00000529691.1_Silent_p.L75L			O95125	ZN202_HUMAN	zinc finger protein 202	75	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TCTCTGGTCTCAGCCACTGGT	0.562000													19	48					0	0	0.539581	0	0
NID2	22795	broad.mit.edu	37	14	52535538	52535538	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:52535538C>A	ENST00000216286.5	-	1	174	c.175G>T	c.(175-177)Gtg>Ttg	p.V59L	NID2_ENST00000541773.1_Splice_Site_p.V6_splice	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	59						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GCCAGCTTCACCACGGCTGAG	0.637000													22	37					2.48779e-11	2.72313e-11	0.693898	1	0
AK5	26289	broad.mit.edu	37	1	77752661	77752661	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:77752661A>C	ENST00000344720.5	+	2	1044	c.18A>C	c.(16-18)gaA>gaC	p.E6D	AK5_ENST00000354567.2_Missense_Mutation_p.E32D|AK5_ENST00000317704.4_3'UTR	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	32					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						CTAAGCCCGAAGATCCAGTAG	0.338000													34	44					0	0	0.796494	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602466	234602466	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:234602466C>T	ENST00000305139.6	+	1	955	c.816C>T	c.(814-816)gtC>gtT	p.V272V	UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Silent_p.V5V|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000480628.1_3'UTR|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|AC114812.8_ENST00000439336.1_RNA|UGT1A6_ENST00000406651.1_Silent_p.V5V|UGT1A7_ENST00000373426.3_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CCAACATGGTCTTCATTGGAG	0.438000													243	375					0	0	0.870114	0	0
MYH2	4620	broad.mit.edu	37	17	10433049	10433049	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:10433049G>T	ENST00000245503.5	-	24	3333	c.2949C>A	c.(2947-2949)aaC>aaA	p.N983K	CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.N983K	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	983					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTTCTGTGAGGTTTTTCACCT	0.473000													90	87					2.68873e-43	3.14494e-43	0.870114	1	0
ADAR	103	broad.mit.edu	37	1	154573540	154573540	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:154573540C>T	ENST00000368474.4	-	2	1777	c.1578G>A	c.(1576-1578)caG>caA	p.Q526Q	ADAR_ENST00000368471.3_Silent_p.Q231Q|ADAR_ENST00000292205.5_Silent_p.Q569Q	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	526	DRBM 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GTGGTCCACTCTGCTCTATCA	0.517000													18	97					0	0	0.539581	0	0
REN	5972	broad.mit.edu	37	1	204124994	204124994	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:204124994A>G	ENST00000367195.2	-	8	1047	c.1004T>C	c.(1003-1005)cTg>cCg	p.L335P	REN_ENST00000272190.8_Missense_Mutation_p.L338P			P00797	RENI_HUMAN	renin	338					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	TTTGCCTCCCAGGTGGAAAGA	0.572000													5	27					0	0	0.248553	0	0
MICAL3	57553	broad.mit.edu	37	22	18389542	18389542	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18389542G>C	ENST00000441493.2	-	2	389	c.37C>G	c.(37-39)Cat>Gat	p.H13D	MICAL3_ENST00000207726.7_Missense_Mutation_p.H13D|MICAL3_ENST00000383094.3_Missense_Mutation_p.H13D|MICAL3_ENST00000585038.1_Missense_Mutation_p.H13D|MICAL3_ENST00000429452.1_Missense_Mutation_p.H13D|MICAL3_ENST00000444520.1_Missense_Mutation_p.H13D|MICAL3_ENST00000414725.2_Missense_Mutation_p.H13D|MICAL3_ENST00000400561.2_Missense_Mutation_p.H13D	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	13						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		AAGAGGACATGAGCTGGGTTC	0.577000													18	63					0	0	0.520397	0	0
ANKRD50	57182	broad.mit.edu	37	4	125592804	125592804	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:125592804G>C	ENST00000504087.1	-	4	2665	c.1628C>G	c.(1627-1629)tCa>tGa	p.S543*	ANKRD50_ENST00000515641.1_Nonsense_Mutation_p.S364*	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	543										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						TCTCCCATTTGAATCACACTG	0.398000													42	11					0	0	0.840704	0	0
PHF13	148479	broad.mit.edu	37	1	6680226	6680226	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:6680226T>G	ENST00000377648.4	+	3	887	c.505T>G	c.(505-507)Tcg>Gcg	p.S169A	PHF13_ENST00000495385.1_Intron	NM_153812.2	NP_722519.2	Q86YI8	PHF13_HUMAN	PHD finger protein 13	169					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(3)	7	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		CGACCCCTGCTCGGGCTGGGA	0.597000													16	31					0	0	0.520397	0	0
ABCA5	23461	broad.mit.edu	37	17	67287394	67287394	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:67287394C>T	ENST00000392676.3	-	12	1633	c.1569G>A	c.(1567-1569)ttG>ttA	p.L523L	ABCA5_ENST00000392677.2_Silent_p.L523L|ABCA5_ENST00000588877.1_Silent_p.L523L			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	523	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					GAATATTCATCAATGTACTCT	0.338000													10	46					0	0	0.435327	0	0
FAM204A	63877	broad.mit.edu	37	10	120094625	120094625	+	Splice_Site	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:120094625C>A	ENST00000369183.4	-	6	713		c.e6+1		FAM204A_ENST00000369172.4_Splice_Site|FAM204A_ENST00000469758.1_Splice_Site	NM_022063.2	NP_071346.1	Q9H8W3	F204A_HUMAN	family with sequence similarity 204, member A											kidney(1)|large_intestine(5)|lung(4)|ovary(1)	11						AAAGATATTACCTTCTCAACT	0.363000													6	51					0.00307968	0.00314768	0.278610	1	0
GPR161	23432	broad.mit.edu	37	1	168059864	168059864	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:168059864C>T	ENST00000367838.1	-	6	1455	c.1142G>A	c.(1141-1143)gGa>gAa	p.G381E	GPR161_ENST00000539777.1_Missense_Mutation_p.G303E|GPR161_ENST00000271357.5_Missense_Mutation_p.G381E|GPR161_ENST00000537209.1_Missense_Mutation_p.G401E|GPR161_ENST00000361697.2_Missense_Mutation_p.G381E|GPR161_ENST00000367835.1_Missense_Mutation_p.G381E|GPR161_ENST00000367836.1_Missense_Mutation_p.G249E|GPR161_ENST00000546300.1_Missense_Mutation_p.G267E	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	381					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CAGGGGCTGTCCACCTGCCAT	0.597000													6	13					0	0	0.307466	0	0
CDK12	51755	broad.mit.edu	37	17	37627593	37627593	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:37627593C>G	ENST00000447079.4	+	2	1541	c.1508C>G	c.(1507-1509)tCt>tGt	p.S503C	CDK12_ENST00000430627.2_Missense_Mutation_p.S503C	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	503					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						ACAAGAGACTCTAAACCCATA	0.428000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			26	111					0	0	0.693898	0	0
EPHA5	2044	broad.mit.edu	37	4	66361187	66361187	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:66361187G>T	ENST00000273854.3	-	4	1585	c.985C>A	c.(985-987)Cat>Aat	p.H329N	EPHA5_ENST00000511294.1_Missense_Mutation_p.H329N|EPHA5_ENST00000354839.4_Missense_Mutation_p.H329N|EPHA5_ENST00000432638.2_Intron	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	329	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						GCTTCCTCATGGGTATAACTG	0.468000										TSP Lung(17;0.13)			37	73					1.04594e-18	1.18078e-18	0.819951	1	0
PLCE1	51196	broad.mit.edu	37	10	95892095	95892095	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:95892095C>G	ENST00000260766.3	+	3	2005	c.1371C>G	c.(1369-1371)ctC>ctG	p.L457L	PLCE1_ENST00000371375.1_Silent_p.L149L|PLCE1_ENST00000371380.2_Silent_p.L457L|PLCE1_ENST00000371385.3_Silent_p.L149L	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	457					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GCGCCACCCTCCAAAGGACTT	0.517000													65	64					0	0	0.870114	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153973168	153973168	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:153973168C>G	ENST00000356448.4	+	15	2806	c.2522C>G	c.(2521-2523)cCt>cGt	p.P841R	ARHGEF26_ENST00000465817.1_Intron|ARHGEF26_ENST00000465093.1_Missense_Mutation_p.P841R|ARHGEF26_ENST00000483068.1_3'UTR	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	841	SH3.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						GGCTGGTTTCCTATGGAATGT	0.468000													16	63					0	0	0.500413	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640336	99640336	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:99640336C>A	ENST00000547776.2	-	13	2062	c.2063G>T	c.(2062-2064)gGc>gTc	p.G688V	ANKS1B_ENST00000329257.7_Missense_Mutation_p.G688V|ANKS1B_ENST00000547010.1_Missense_Mutation_p.G268V|ANKS1B_ENST00000550833.1_5'UTR	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	688						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane		p.G688D(1)		NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TGATCTTGTGCCAACAATGGT	0.433000													8	38					0.00307968	0.00314768	0.278610	1	0
PLXNB2	23654	broad.mit.edu	37	22	50724681	50724681	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:50724681G>A	ENST00000449103.1	-	9	1938	c.1798C>T	c.(1798-1800)Cga>Tga	p.R600*	PLXNB2_ENST00000359337.4_Nonsense_Mutation_p.R600*|PLXNB2_ENST00000496720.1_5'UTR			O15031	PLXB2_HUMAN	plexin B2	600					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ATGTTGCCTCGTCTAAGGAGG	0.647000													59	20					0	0	0.870114	0	0
ASB10	136371	broad.mit.edu	37	7	150878413	150878413	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:150878413T>C	ENST00000422024.1	-	3	977	c.852A>G	c.(850-852)gcA>gcG	p.A284A	ASB10_ENST00000434669.1_Silent_p.A284A|ASB10_ENST00000377867.3_Silent_p.A224A|ASB10_ENST00000420175.2_Silent_p.A239A|ASB10_ENST00000275838.1_Silent_p.A239A	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	239					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATCAGGACATGCCCCCCGTC	0.652000													5	15					0	0	0.217242	0	0
ENKUR	219670	broad.mit.edu	37	10	25284722	25284722	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:25284722C>T	ENST00000331161.4	-	3	519	c.300G>A	c.(298-300)caG>caA	p.Q100Q	ENKUR_ENST00000376363.1_Silent_p.Q100Q	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	100						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						TTTTTCCACTCTGTATTCCCA	0.358000													27	94					0	0	0.693898	0	0
C5orf28	64417	broad.mit.edu	37	5	43453838	43453838	+	Silent	SNP	T	T	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:43453838T>A	ENST00000500337.2	-	4	565	c.234A>T	c.(232-234)ggA>ggT	p.G78G	C5orf28_ENST00000512085.1_Silent_p.G78G|C5orf28_ENST00000537319.1_Intron|C5orf28_ENST00000510130.1_Intron|C5orf28_ENST00000511525.1_Intron|C5orf28_ENST00000397080.3_Silent_p.G78G			Q0VDI3	CE028_HUMAN	chromosome 5 open reading frame 28	78						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(5)	9	Lung NSC(6;2.07e-05)					AAATGATTTCTCCAAAGTCAG	0.393000													33	128					0	0	0.788014	0	0
CPAMD8	27151	broad.mit.edu	37	19	17086829	17086829	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:17086829G>A	ENST00000443236.1	-	16	2063	c.2032C>T	c.(2032-2034)Cgg>Tgg	p.R678W	CPAMD8_ENST00000388925.4_Intron	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	631						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GGAGTCAGCCGGAACCCAGAC	0.602000													12	11					0	0	0.457914	0	0
GLI2	2736	broad.mit.edu	37	2	121732650	121732650	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:121732650A>G	ENST00000452319.1	+	9	1393	c.1333A>G	c.(1333-1335)Acc>Gcc	p.T445A	GLI2_ENST00000314490.11_Missense_Mutation_p.T117A|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Missense_Mutation_p.T445A			P10070	GLI2_HUMAN	GLI family zinc finger 2	445					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGAAGACTGCACCAAGGAGTA	0.597000													9	50					0	0	0.361761	0	0
ACSS1	84532	broad.mit.edu	37	20	24993469	24993469	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:24993469G>A	ENST00000537502.1	-	9	2968	c.1437C>T	c.(1435-1437)acC>acT	p.T479T	ACSS1_ENST00000542618.1_Silent_p.T441T|ACSS1_ENST00000432802.2_Intron|ACSS1_ENST00000323482.4_Silent_p.T562T			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	562					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CAATCTCTGCGGTCCCCAGCC	0.597000													38	34					0	0	0.819951	0	0
PSG8	440533	broad.mit.edu	37	19	43269720	43269720	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:43269720G>C	ENST00000404209.4	-	1	110	c.14C>G	c.(13-15)tCa>tGa	p.S5*	PSG8_ENST00000401467.2_Intron|PSG8_ENST00000306511.4_Nonsense_Mutation_p.S5*|PSG8_ENST00000406636.3_Nonsense_Mutation_p.S5*	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	5						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GGGAGGGGCTGAGAGGAGCCC	0.592000													18	62					0	0	0.592651	0	0
DRD3	1814	broad.mit.edu	37	3	113850024	113850024	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:113850024T>G	ENST00000383673.2	-	6	1377	c.947A>C	c.(946-948)cAa>cCa	p.Q316P	DRD3_ENST00000460779.1_Missense_Mutation_p.Q316P|DRD3_ENST00000295881.7_Intron|DRD3_ENST00000467632.1_Missense_Mutation_p.Q316P	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	316					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TCCCCGAGGTTGCAGGGGCCC	0.537000													21	94					0	0	0.608945	0	0
NLRP8	126205	broad.mit.edu	37	19	56481960	56481960	+	Missense_Mutation	SNP	A	A	C	rs143689901		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:56481960A>C	ENST00000291971.3	+	6	2503	c.2432A>C	c.(2431-2433)aAt>aCt	p.N811T	NLRP8_ENST00000590542.1_Missense_Mutation_p.N811T	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	811						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTTGGCAATAATCTTCAAGGT	0.483000													23	177					0	0	0.654019	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	65					0	0	0.184627	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													3	77					0	0	0.115264	0	0
NCLN	56926	broad.mit.edu	37	19	3192652	3192652	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:3192652C>T	ENST00000246117.4	+	2	800	c.369C>T	c.(367-369)gtC>gtT	p.V123V	NCLN_ENST00000590671.1_Silent_p.V49V	NM_020170.3	NP_064555.2	Q969V3	NCLN_HUMAN	nicalin	123					proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGACGTCGTCCGGGTGA	0.697000													7	15					0	0	0.248553	0	0
GALNT5	11227	broad.mit.edu	37	2	158157196	158157196	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:158157196G>A	ENST00000259056.4	+	7	2609	c.2124G>A	c.(2122-2124)atG>atA	p.M708I		NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	708	Catalytic subdomain B.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						AGGTGTGGATGTGTGGTGGTG	0.428000													9	65					0	0	0.307466	0	0
AFMID	125061	broad.mit.edu	37	17	76187113	76187113	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:76187113G>C	ENST00000409257.5	+	2	180	c.126G>C	c.(124-126)ttG>ttC	p.L42F	AFMID_ENST00000589256.1_Missense_Mutation_p.L42F|AFMID_ENST00000586731.1_Missense_Mutation_p.L25F|AFMID_ENST00000588800.1_Missense_Mutation_p.L42F|AFMID_ENST00000327898.5_Missense_Mutation_p.L42F|AFMID_ENST00000591952.1_Missense_Mutation_p.L42F	NM_001010982.4|NM_001145526.2	NP_001010982.2|NP_001138998.1	Q63HM1	AFMID_HUMAN	arylformamidase	42						cytosol|nucleus	arylformamidase activity			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)	19			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			AGGAAGCCTTGAGGACCTACT	0.542000													4	12					0	0	0.217242	0	0
AQP6	363	broad.mit.edu	37	12	50367243	50367243	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:50367243C>G	ENST00000315520.5	+	1	624	c.287C>G	c.(286-288)tCt>tGt	p.S96C	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	96					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						TCCCACATCTCTCTGCCCCGT	0.677000													15	37					0	0	0.479597	0	0
ZNF207	7756	broad.mit.edu	37	17	30688523	30688523	+	Silent	SNP	C	C	T	rs146844075		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:30688523C>T	ENST00000394670.4	+	6	757	c.588C>T	c.(586-588)tgC>tgT	p.C196C	ZNF207_ENST00000321233.6_Intron|ZNF207_ENST00000342555.6_Silent_p.C199C|ZNF207_ENST00000341711.6_Silent_p.C97C|ZNF207_ENST00000577908.1_Silent_p.C196C|ZNF207_ENST00000394673.2_Silent_p.C196C	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207	184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			AGTCATTTTGCGGTGAAAACA	0.318000													3	28					0	0	0.150653	0	0
OR6C4	341418	broad.mit.edu	37	12	55945429	55945429	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:55945429T>C	ENST00000394256.2	+	1	447	c.419T>C	c.(418-420)aTa>aCa	p.I140T	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						AGAGTCTGCATACAACTAGTG	0.468000													13	107					0	0	0.457914	0	0
RWDD2B	10069	broad.mit.edu	37	21	30380432	30380432	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr21:30380432C>G	ENST00000493196.1	-	4	475	c.375G>C	c.(373-375)ttG>ttC	p.L125F	RWDD2B_ENST00000486719.1_5'UTR	NM_016940.2	NP_058636.1	P57060	RWD2B_HUMAN	RWD domain containing 2B	125	RWD.									endometrium(1)|kidney(1)|large_intestine(8)|lung(2)	12						GGGATCTACTCAATAATACTG	0.358000													13	35					0	0	0.435327	0	0
EHD1	10938	broad.mit.edu	37	11	64645866	64645866	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:64645866C>A	ENST00000320631.3	-	1	325	c.71G>T	c.(70-72)gGg>gTg	p.G24V	EHD1_ENST00000359393.2_Missense_Mutation_p.G24V	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	24					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						CTGCCGCAGCCCCTCAGCCAC	0.662000													16	19					2.89027e-11	3.14244e-11	0.624587	1	0
RAB25	57111	broad.mit.edu	37	1	156038115	156038115	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:156038115G>T	ENST00000361084.5	+	3	535	c.294G>T	c.(292-294)caG>caT	p.Q98H	RAB25_ENST00000487325.1_3'UTR	NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	98					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					CCAAGCACCAGACCTATGCTG	0.547000													68	77					9.5628e-27	1.10261e-26	0.870114	1	0
ZMAT1	84460	broad.mit.edu	37	X	101159303	101159303	+	Splice_Site	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:101159303T>C	ENST00000372782.3	-	3	169	c.121_splice	c.e3-1	p.D41_splice	ZMAT1_ENST00000540921.1_Splice_Site_p.D41_splice|ZMAT1_ENST00000458570.1_5'UTR	NM_001011657.3	NP_001011657.2	A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	0						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						CCAAATGGCGTCTGTGAATAA	0.299000													8	15					0	0	0.307466	0	0
MDGA2	161357	broad.mit.edu	37	14	47426600	47426600	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:47426600C>T	ENST00000426342.1	-	9	1918	c.1172G>A	c.(1171-1173)gGg>gAg	p.G391E	MDGA2_ENST00000439988.2_Missense_Mutation_p.G620E|MDGA2_ENST00000399232.2_Missense_Mutation_p.G689E|MDGA2_ENST00000357362.3_Missense_Mutation_p.G391E	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	620	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						GCTGCATCTCCCAGCTCCAGC	0.358000													17	35					0	0	0.592651	0	0
NDUFAF7	55471	broad.mit.edu	37	2	37459318	37459318	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:37459318C>G	ENST00000002125.4	+	2	165	c.125C>G	c.(124-126)cCg>cGg	p.P42R	NDUFAF7_ENST00000483999.1_Intron|NDUFAF7_ENST00000336237.6_Missense_Mutation_p.P42R	NM_144736.4	NP_653337.1			NADH dehydrogenase (ubiquinone) complex I, assembly factor 7																		CCGGTGACGCCGATGCTGCGG	0.478000													6	111					0	0	0.248553	0	0
PAEP	5047	broad.mit.edu	37	9	138454276	138454276	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:138454276G>A	ENST00000479141.1	+	2	277	c.233G>A	c.(232-234)aGa>aAa	p.R78K	PAEP_ENST00000371766.2_Missense_Mutation_p.R78K|PAEP_ENST00000277508.5_Missense_Mutation_p.R78K	NM_002571.2	NP_002562.2	P09466	PAEP_HUMAN	progestagen-associated endometrial protein	78					multicellular organismal development	extracellular region	binding|transporter activity			cervix(1)|endometrium(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	6				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		GTTCTGCACAGATGGTGGGTT	0.622000													11	80					0	0	0.411799	0	0
CASP14	23581	broad.mit.edu	37	19	15164426	15164426	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:15164426G>C	ENST00000427043.3	+	3	469	c.161G>C	c.(160-162)aGa>aCa	p.R54T	CASP14_ENST00000221740.1_Missense_Mutation_p.R54T	NM_012114.2	NP_036246.1	P31944	CASPE_HUMAN	caspase 14, apoptosis-related cysteine peptidase	54					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(3)	26						ACCATGAAAAGAGACCCCACT	0.537000													17	60					0	0	0.500413	0	0
DNAH5	1767	broad.mit.edu	37	5	13901563	13901563	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:13901563G>A	ENST00000265104.4	-	14	1954	c.1850C>T	c.(1849-1851)gCt>gTt	p.A617V		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	617	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTGGTTTCGAGCCAGAGGAGG	0.478000									Kartagener syndrome				18	79					0	0	0.520397	0	0
LDLR	3949	broad.mit.edu	37	19	11233896	11233896	+	Silent	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:11233896A>G	ENST00000558518.1	+	15	2374	c.2187A>G	c.(2185-2187)ctA>ctG	p.L729L	LDLR_ENST00000535915.1_Silent_p.L688L|LDLR_ENST00000455727.2_Silent_p.L561L|LDLR_ENST00000545707.1_Silent_p.L551L|LDLR_ENST00000557933.1_Silent_p.L729L|LDLR_ENST00000558013.1_Silent_p.L729L	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	729	Clustered O-linked oligosaccharides.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CCGTCAGGCTAAAGGTCAGCT	0.612000													14	47					0	0	0.457914	0	0
PKD1L2	114780	broad.mit.edu	37	16	81183305	81183305	+	RNA	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:81183305C>G	ENST00000533478.1	-	0	2798				PKD1L2_ENST00000525539.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CCAAGTCCATCTTTTGCTCAG	0.592000													5	19					0	0	0.217242	0	0
TTC7A	57217	broad.mit.edu	37	2	47278982	47278982	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:47278982G>T	ENST00000319190.5	+	18	2483	c.2115G>T	c.(2113-2115)caG>caT	p.Q705H	TTC7A_ENST00000409245.1_Missense_Mutation_p.Q671H|TTC7A_ENST00000394850.2_Missense_Mutation_p.Q729H|TTC7A_ENST00000263737.6_Missense_Mutation_p.Q351H	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	705							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GCCCCATGCAGCTGTGGACCA	0.657000													18	15					2.48551e-13	2.75789e-13	0.520397	1	0
STK25	10494	broad.mit.edu	37	2	242435884	242435884	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:242435884G>C	ENST00000316586.4	-	11	1519	c.1170C>G	c.(1168-1170)ttC>ttG	p.F390L	STK25_ENST00000405585.1_Missense_Mutation_p.F313L|STK25_ENST00000535007.1_Missense_Mutation_p.F296L|STK25_ENST00000478403.1_5'UTR|STK25_ENST00000403346.3_Missense_Mutation_p.F390L|STK25_ENST00000543554.1_Missense_Mutation_p.F296L|STK25_ENST00000405883.3_Missense_Mutation_p.F313L|STK25_ENST00000401869.1_Missense_Mutation_p.F390L	NM_001271977.1|NM_001271978.1	NP_001258906.1|NP_001258907.1	O00506	STK25_HUMAN	serine/threonine kinase 25	390					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	10		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CGGCCAGGCTGAAGGCGTTCT	0.657000													13	59					0	0	0.411799	0	0
SYDE2	84144	broad.mit.edu	37	1	85630216	85630216	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:85630216G>A	ENST00000341460.5	-	6	3127	c.3078C>T	c.(3076-3078)ctC>ctT	p.L1026L		NM_032184.1	NP_115560.1	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	1026	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	20				all cancers(265;0.0126)|Epithelial(280;0.0336)		TACCTGGCCAGAGTTGGAGTA	0.318000													5	11					0	0	0.184627	0	0
ELK4	2005	broad.mit.edu	37	1	205589519	205589519	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:205589519C>G	ENST00000357992.4	-	3	994	c.655G>C	c.(655-657)Gaa>Caa	p.E219Q	ELK4_ENST00000289703.4_Missense_Mutation_p.E219Q	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			ATAGTTTCTTCTGAAGATGGA	0.473000			T	SLC45A3	prostate								19	72					0	0	0.575678	0	0
CMYA5	202333	broad.mit.edu	37	5	79095241	79095241	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:79095241G>A	ENST00000446378.2	+	13	12043	c.12012G>A	c.(12010-12012)gaG>gaA	p.E4004E	CTC-431G16.2_ENST00000421252.2_RNA	NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	4004	B30.2/SPRY.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATGTGACTGAGCGTCCAGCCA	0.443000													7	45					0	0	0.248553	0	0
NUP155	9631	broad.mit.edu	37	5	37371159	37371159	+	Translation_Start_Site	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:37371159G>C	ENST00000231498.3	-	0	124				NUP155_ENST00000513532.1_De_novo_Start_OutOfFrame	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTTAGCTTAGATCCGCCGCC	0.557000													3	27					0	0	0.115264	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378031	55378031	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:55378031G>A	ENST00000326321.3	+	9	1246	c.1213G>A	c.(1213-1215)Gtt>Att	p.V405I	KIR3DL2_ENST00000270442.5_Missense_Mutation_p.V388I|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.V405I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	405					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		GGATCACTGCGTTTTCATACA	0.512000													56	135					0	0	0.870114	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626801	108626801	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:108626801T>C	ENST00000264047.2	+	9	1503	c.1227T>C	c.(1225-1227)agT>agC	p.S409S	SLC5A7_ENST00000540517.1_Silent_p.S304S|SLC5A7_ENST00000409059.1_Silent_p.S409S	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	409					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GGTACCTCAGTTCTGACCTTG	0.483000													28	40					0	0	0.706142	0	0
C22orf15	150248	broad.mit.edu	37	22	24106898	24106898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:24106898C>T	ENST00000305199.5	+	4	428	c.328C>T	c.(328-330)Cag>Tag	p.Q110*	C22orf15_ENST00000402217.3_Missense_Mutation_p.A108V|C22orf15_ENST00000382821.3_Missense_Mutation_p.A113V			Q8WYQ4	CV015_HUMAN	chromosome 22 open reading frame 15	0										breast(1)|pancreas(1)	2		Medulloblastoma(6;6.27e-05)|all_neural(6;0.00518)				CCAGAGCTGGCAGGTGAGTGT	0.587000													11	25					0	0	0.387290	0	0
CDCA7	83879	broad.mit.edu	37	2	174229611	174229611	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:174229611G>T	ENST00000306721.3	+	6	891	c.788G>T	c.(787-789)aGg>aTg	p.R263M	CDCA7_ENST00000410101.3_Missense_Mutation_p.R219M|CDCA7_ENST00000347703.3_Missense_Mutation_p.R184M|CDCA7_ENST00000392567.2_Missense_Mutation_p.R184M|CDCA7_ENST00000410019.3_Missense_Mutation_p.R142M	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	184	Mediates transcriptional activity.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			ACCAGGTCAAGGTCCCGGATC	0.547000													10	42					1.76689e-08	1.90191e-08	0.335167	1	0
SPAG17	200162	broad.mit.edu	37	1	118693935	118693935	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:118693935G>C	ENST00000336338.5	-	2	210	c.145C>G	c.(145-147)Ctc>Gtc	p.L49V		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	49						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCTTGGATGAGAAGATCATCT	0.453000													8	41					0	0	0.335167	0	0
SNX25	83891	broad.mit.edu	37	4	186188282	186188282	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:186188282C>T	ENST00000504273.1	+	5	866	c.572C>T	c.(571-573)tCt>tTt	p.S191F	SNX25_ENST00000264694.8_Missense_Mutation_p.S191F			Q9H3E2	SNX25_HUMAN	sorting nexin 25	191					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AACAGCAACTCTGATGTGGAG	0.438000													15	51					0	0	0.520397	0	0
ZNF257	113835	broad.mit.edu	37	19	22271115	22271115	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:22271115T>A	ENST00000594947.1	+	4	707	c.563T>A	c.(562-564)cTa>cAa	p.L188Q	ZNF257_ENST00000600162.1_3'UTR	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTTTCACAACTAACTCGACAT	0.338000													4	18					0	0	0.184627	0	0
TUFT1	7286	broad.mit.edu	37	1	151552206	151552206	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:151552206G>C	ENST00000368849.3	+	11	1068	c.1006G>C	c.(1006-1008)Gag>Cag	p.E336Q	TUFT1_ENST00000538902.1_Missense_Mutation_p.E355Q|TUFT1_ENST00000353024.3_Missense_Mutation_p.E277Q|TUFT1_ENST00000368848.2_Missense_Mutation_p.E311Q|TUFT1_ENST00000392712.3_Missense_Mutation_p.E281Q	NM_020127.2	NP_064512.1	Q9NNX1	TUFT1_HUMAN	tuftelin 1	336					bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCTGGAGGCAGAGGTGTGTGT	0.532000													5	12					0	0	0.217242	0	0
TNN	63923	broad.mit.edu	37	1	175116116	175116116	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:175116116T>C	ENST00000239462.4	+	19	3922	c.3809T>C	c.(3808-3810)gTg>gCg	p.V1270A		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1270	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ATTCCTTACGTGGAGTTGAAA	0.522000											OREG0013992	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	45					0	0	0.479597	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130897699	130897699	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:130897699A>T	ENST00000509018.1	-	5	528	c.323T>A	c.(322-324)cTt>cAt	p.L108H	RAPGEF6_ENST00000507093.1_Missense_Mutation_p.L108H|RAPGEF6_ENST00000296859.6_Missense_Mutation_p.L108H|RAPGEF6_ENST00000510071.1_Missense_Mutation_p.L108H|FNIP1_ENST00000514667.1_Missense_Mutation_p.L158H|RAPGEF6_ENST00000307984.5_Missense_Mutation_p.L108H|RAPGEF6_ENST00000503398.2_Intron|RAPGEF6_ENST00000308008.6_Missense_Mutation_p.L108H	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	108					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTCTAATACAAGACAATCACA	0.274000													63	12					0	0	0.870114	0	0
SYBU	55638	broad.mit.edu	37	8	110590243	110590243	+	Silent	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:110590243A>G	ENST00000399066.3	-	5	1456	c.729T>C	c.(727-729)cgT>cgC	p.R243R	SYBU_ENST00000532779.1_Silent_p.R178R|SYBU_ENST00000422135.1_Silent_p.R246R|SYBU_ENST00000527707.1_5'UTR|SYBU_ENST00000446070.2_Silent_p.R245R|SYBU_ENST00000440310.1_Silent_p.R246R|SYBU_ENST00000276646.9_Silent_p.R246R|SYBU_ENST00000424158.2_Silent_p.R251R|SYBU_ENST00000528331.1_Silent_p.R127R|SYBU_ENST00000433638.1_Silent_p.R246R|SYBU_ENST00000408908.2_Silent_p.R246R|SYBU_ENST00000529690.1_Silent_p.R116R|SYBU_ENST00000533895.1_Silent_p.R245R|SYBU_ENST00000529175.1_Silent_p.R40R|SYBU_ENST00000408889.3_Silent_p.R127R|SYBU_ENST00000533171.1_Silent_p.R246R|SYBU_ENST00000528647.1_Silent_p.R245R|SYBU_ENST00000533065.1_Silent_p.R127R|SYBU_ENST00000419099.1_Silent_p.R245R	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	246	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						ACCTTCCAGAACGCCTGAAAC	0.428000													30	113					0	0	0.750413	0	0
STXBP5L	9515	broad.mit.edu	37	3	120941894	120941894	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:120941894C>A	ENST00000273666.6	+	11	1272	c.1001C>A	c.(1000-1002)gCt>gAt	p.A334D	STXBP5L_ENST00000492541.1_Missense_Mutation_p.A334D|STXBP5L_ENST00000497029.1_Missense_Mutation_p.A334D|STXBP5L_ENST00000471454.1_Missense_Mutation_p.A334D|STXBP5L_ENST00000472879.1_Missense_Mutation_p.A334D	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	334					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TATGACAAAGCTTGTAGAAGA	0.368000													33	59					1.26612e-14	1.42438e-14	0.779181	1	0
VGF	7425	broad.mit.edu	37	7	100806475	100806475	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:100806475G>A	ENST00000249330.2	-	2	1889	c.1650C>T	c.(1648-1650)atC>atT	p.I550I	VGF_ENST00000445482.2_Silent_p.I550I	NM_003378.3	NP_003369.2	O15240	VGF_HUMAN	VGF nerve growth factor inducible	550					response to cAMP	extracellular space|transport vesicle	growth factor activity			cervix(1)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	9	Lung NSC(181;0.168)|all_lung(186;0.215)					TCCGCGGCCGGATGTAGTTGG	0.721000													7	53					0	0	0.278610	0	0
NPLOC4	55666	broad.mit.edu	37	17	79534533	79534533	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79534533C>A	ENST00000374747.5	-	15	1605	c.1476G>T	c.(1474-1476)ttG>ttT	p.L492F	NPLOC4_ENST00000331134.6_Missense_Mutation_p.L492F|NPLOC4_ENST00000539314.1_Missense_Mutation_p.L331F			Q8TAT6	NPL4_HUMAN	nuclear protein localization 4 homolog (S. cerevisiae)	492					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TATTCTGAGACAAATAGGTGG	0.478000													6	9					0.00116845	0.00120566	0.217242	1	0
NLRP13	126204	broad.mit.edu	37	19	56413454	56413454	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:56413454G>C	ENST00000588751.1	-	9	2760	c.2736C>G	c.(2734-2736)gtC>gtG	p.V912V	NLRP13_ENST00000342929.3_Silent_p.V912V			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	912							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACAGGAACTTGACTCCCTCGT	0.552000													14	57					0	0	0.479597	0	0
DAPK3	1613	broad.mit.edu	37	19	3964692	3964692	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:3964692G>C	ENST00000545797.2	-	3	603	c.360C>G	c.(358-360)ctC>ctG	p.L120L	DAPK3_ENST00000301264.3_Silent_p.L120L			O43293	DAPK3_HUMAN	death-associated protein kinase 3	120	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(2)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGATCTGCTTGAGGAACTGGG	0.632000													27	66					0	0	0.717897	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412107	105412107	+	Silent	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:105412107G>C	ENST00000333244.5	-	7	9800	c.9681C>G	c.(9679-9681)ccC>ccG	p.P3227P	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3227						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTGCAACTTGGGCAGGTGCC	0.617000													34	389					0	0	0.760397	0	0
JMJD1C	221037	broad.mit.edu	37	10	64968896	64968896	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:64968896G>T	ENST00000399262.2	-	9	3012	c.2794C>A	c.(2794-2796)Cct>Act	p.P932T	JMJD1C_ENST00000402544.1_Missense_Mutation_p.P713T|JMJD1C_ENST00000542921.1_Missense_Mutation_p.P750T|JMJD1C_ENST00000399251.1_Missense_Mutation_p.P713T	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	932					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGCCGATGAGGCTCTGCACTG	0.443000													57	44					2.2129e-31	2.56982e-31	0.870114	1	0
TXNL1	9352	broad.mit.edu	37	18	54285302	54285302	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:54285302T>G	ENST00000217515.6	-	4	629	c.425A>C	c.(424-426)gAt>gCt	p.D142A	TXNL1_ENST00000590954.1_Missense_Mutation_p.D142A|TXNL1_ENST00000540155.1_Missense_Mutation_p.D19A	NM_004786.2	NP_004777.1	O43396	TXNL1_HUMAN	thioredoxin-like 1	142	PITH.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		TCCATGCTCATCACTTTCATT	0.353000													17	31					0	0	0.500413	0	0
GLI3	2737	broad.mit.edu	37	7	42079708	42079708	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:42079708C>T	ENST00000395925.3	-	7	1041	c.957G>A	c.(955-957)acG>acA	p.T319T	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	319					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TATTGAGAATCGTGACCAAGG	0.468000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				7	52					0	0	0.248553	0	0
MPPED1	758	broad.mit.edu	37	22	43898630	43898630	+	Silent	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:43898630C>A	ENST00000417669.1	+	6	1299	c.855C>A	c.(853-855)atC>atA	p.I285I	MPPED1_ENST00000538182.1_Silent_p.I318I|MPPED1_ENST00000443721.1_Silent_p.I285I|MPPED1_ENST00000414469.2_Silent_p.I179I|MPPED1_ENST00000439548.1_Silent_p.I127I|MPPED1_ENST00000542779.1_Silent_p.I285I			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	285							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				TTGGCCACATCCACGAAGGTC	0.612000													14	29					6.31663e-08	6.77678e-08	0.479597	1	0
ING3	54556	broad.mit.edu	37	7	120613295	120613295	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:120613295G>C	ENST00000315870.5	+	11	1286	c.1138G>C	c.(1138-1140)Gat>Cat	p.D380H	ING3_ENST00000431467.1_Missense_Mutation_p.D365H	NM_019071.2	NP_061944.2	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3	380				Missing (in Ref. 5; CAC48260).	histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			NS(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	12	all_neural(327;0.117)					TGATAACCAAGATGTAAGTAT	0.284000													15	62					0	0	0.500413	0	0
ABCB5	340273	broad.mit.edu	37	7	20739693	20739693	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:20739693G>C	ENST00000404938.2	+	19	2924	c.2272G>C	c.(2272-2274)Ggc>Cgc	p.G758R	ABCB5_ENST00000258738.6_Missense_Mutation_p.G313R	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	313	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						ATTATTTTACGGCAGAGCAGG	0.303000													26	59					0	0	0.706142	0	0
POLR3A	11128	broad.mit.edu	37	10	79764570	79764570	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:79764570C>T	ENST00000372371.3	-	16	2288	c.2151G>A	c.(2149-2151)ctG>ctA	p.L717L		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	717					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			AGCCGGCATTCAGCAACTCAT	0.542000													8	40					0	0	0.307466	0	0
VRK3	51231	broad.mit.edu	37	19	50496192	50496192	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:50496192G>C	ENST00000599538.1	-	10	1552	c.888C>G	c.(886-888)ttC>ttG	p.F296L	VRK3_ENST00000377011.2_Missense_Mutation_p.F246L|VRK3_ENST00000316763.3_Missense_Mutation_p.F296L|VRK3_ENST00000601912.1_Missense_Mutation_p.F246L|VRK3_ENST00000594092.1_Missense_Mutation_p.F296L|VRK3_ENST00000443401.2_Missense_Mutation_p.F65L|VRK3_ENST00000601341.1_Missense_Mutation_p.F246L|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000593919.1_Missense_Mutation_p.F296L|VRK3_ENST00000594948.1_Missense_Mutation_p.F296L			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	296	Protein kinase.					nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		TCTCATGGAGGAACTCCAGGG	0.522000													33	94					0	0	0.750413	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114365	27114365	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:27114365G>A	ENST00000396891.4	-	1	254	c.213C>T	c.(211-213)ttC>ttT	p.F71F	HIST1H2BK_ENST00000356950.1_Silent_p.F71F	NM_080593.2	NP_542160.1	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						CGATGCGTTCGAAGATGTCGT	0.602000													86	35					0	0	0.870114	0	0
KIF3B	9371	broad.mit.edu	37	20	30898796	30898796	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:30898796G>A	ENST00000375712.3	+	2	1383	c.1216G>A	c.(1216-1218)Gaa>Aaa	p.E406K	KIF3B_ENST00000418717.2_Intron	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	406	Poly-Glu.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			gggtgaggaggaaggggaTGA	0.557000													8	14					0	0	0.361761	0	0
ALYREF	10189	broad.mit.edu	37	17	79847182	79847182	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79847182C>T	ENST00000331204.4	-	3	419	c.393G>A	c.(391-393)acG>acA	p.T131T	ALYREF_ENST00000505490.2_Silent_p.T138T|ALYREF_ENST00000512673.1_5'UTR	NM_005782.3	NP_005773.3	Q86V81	THOC4_HUMAN	Aly/REF export factor	131	Ala/Arg/Gly-rich.|RRM.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding										CCTTCTTCAGCGTTCCAAATT	0.547000													47	15					0	0	0.870114	0	0
TDRD5	163589	broad.mit.edu	37	1	179561846	179561846	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:179561846G>C	ENST00000444136.1	+	2	346	c.96G>C	c.(94-96)gaG>gaC	p.E32D	TDRD5_ENST00000294848.8_Missense_Mutation_p.E32D|TDRD5_ENST00000367614.1_Missense_Mutation_p.E32D	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	32	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						AGGAGTTGGAGAAGGAGTACC	0.478000													23	106					0	0	0.624587	0	0
ZC3H4	23211	broad.mit.edu	37	19	47575952	47575952	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:47575952C>T	ENST00000253048.5	-	12	1496	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	487							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GCACCTGCTTCTGCATCATCG	0.587000													8	15					0	0	0.278610	0	0
SUN3	256979	broad.mit.edu	37	7	48045610	48045610	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:48045610C>G	ENST00000453192.2	-	7	740	c.497G>C	c.(496-498)aGa>aCa	p.R166T	SUN3_ENST00000412142.1_Missense_Mutation_p.R78T|SUN3_ENST00000297325.4_Missense_Mutation_p.R178T|SUN3_ENST00000395572.2_Missense_Mutation_p.R178T			Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 3	178						integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(8)|liver(1)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTGGTCTTCTCTCAACTTTTT	0.358000													7	33					0	0	0.278610	0	0
RHD	6007	broad.mit.edu	37	1	25611200	25611200	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:25611200C>T	ENST00000328664.4	+	2	440	c.285C>T	c.(283-285)gaC>gaT	p.D95D	RHD_ENST00000357542.4_Silent_p.D95D|RHD_ENST00000342055.5_Silent_p.D95D|RHD_ENST00000568195.1_Silent_p.D95D|RHD_ENST00000454452.2_Silent_p.D95D|RHD_ENST00000417538.2_Silent_p.D95D|RHD_ENST00000423810.2_Silent_p.D95D|RHD_ENST00000423253.1_3'UTR	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	95						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCTGCTGGACGGCTTCCTGA	0.572000													5	53					0	0	0.184627	0	0
KLF3	51274	broad.mit.edu	37	4	38696416	38696416	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:38696416G>A	ENST00000261438.5	+	5	1050	c.745G>A	c.(745-747)Gaa>Aaa	p.E249K		NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	249	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						TTTACCTGTGGAATCCCCGGA	0.478000													11	81					0	0	0.387290	0	0
CCND1	595	broad.mit.edu	37	11	69466006	69466006	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:69466006G>C	ENST00000227507.2	+	5	1071	c.844G>C	c.(844-846)Gac>Cac	p.D282H		NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	282					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	ggaggaggtggaCCTGGCTTG	0.711000			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			8	4					0	0	0.278610	0	0
HTR7	3363	broad.mit.edu	37	10	92508598	92508598	+	Silent	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:92508598C>A	ENST00000371721.3	-	2	1535	c.1293G>T	c.(1291-1293)gtG>gtT	p.V431V	HTR7_ENST00000336152.3_Silent_p.V431V|HTR7_ENST00000371719.2_Silent_p.V431V|HTR7_ENST00000277874.6_Silent_p.V431V			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	431					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	GACCTTACAGCACAAACTCAG	0.483000													47	110					1.02687e-29	1.18823e-29	0.864702	1	0
OR51G1	79324	broad.mit.edu	37	11	4944942	4944942	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:4944942C>T	ENST00000321961.2	-	1	695	c.628G>A	c.(628-630)Ggt>Agt	p.G210S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGTCCACACCCACGGTGCAG	0.552000													8	28					0	0	0.278610	0	0
FAT1	2195	broad.mit.edu	37	4	187627830	187627830	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:187627830G>C	ENST00000441802.2	-	2	3361	c.3152C>G	c.(3151-3153)tCa>tGa	p.S1051*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1051	Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CATTACCAATGAACCAACAGG	0.483000										HNSCC(5;0.00058)			51	26					0	0	0.870114	0	0
SNTG1	54212	broad.mit.edu	37	8	51705261	51705261	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:51705261C>G	ENST00000522124.1	+	19	2087	c.1426C>G	c.(1426-1428)Ctt>Gtt	p.L476V	SNTG1_ENST00000517473.1_Missense_Mutation_p.L439V|SNTG1_ENST00000518864.1_Missense_Mutation_p.L476V|SNTG1_ENST00000276467.5_Missense_Mutation_p.L439V	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	476					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ATTTGCTGTTCTTCACTGCAT	0.363000													18	101					0	0	0.608945	0	0
THUMPD2	80745	broad.mit.edu	37	2	39983088	39983088	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:39983088C>A	ENST00000505747.1	-	7	931	c.904G>T	c.(904-906)Gtt>Ttt	p.V302F	THUMPD2_ENST00000260619.6_Missense_Mutation_p.V272F	NM_025264.4	NP_079540.2	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	302							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	17		all_hematologic(82;0.248)				GGATCTAAAACAAATGCACCA	0.333000													4	64					0.00024832	0.000257047	0.150653	1	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000596604.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	10					0.00909568	0.0092673	0.150653	1	0
TBX6	6911	broad.mit.edu	37	16	30100461	30100461	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:30100461C>G	ENST00000553607.1	-	3	1117	c.424G>C	c.(424-426)Gat>Cat	p.D142H	TBX6_ENST00000395224.2_Missense_Mutation_p.D142H|TBX6_ENST00000279386.2_Missense_Mutation_p.D142H			O95947	TBX6_HUMAN	T-box 6	142					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						GGAATCACATCCAGAAGAAAC	0.662000													17	72					0	0	0.557998	0	0
SAMHD1	25939	broad.mit.edu	37	20	35532577	35532577	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:35532577C>A	ENST00000262878.4	-	13	1685	c.1486G>T	c.(1486-1488)Gaa>Taa	p.E496*		NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	496					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				ATAAAATCTTCAGCCTTCAGT	0.378000													22	108					1.10923e-09	1.20198e-09	0.639603	1	0
C12orf4	57102	broad.mit.edu	37	12	4643433	4643433	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:4643433C>G	ENST00000261250.3	-	3	301	c.214G>C	c.(214-216)Gaa>Caa	p.E72Q	C12orf4_ENST00000545746.1_Missense_Mutation_p.E72Q	NM_020374.2	NP_065107.1	Q9NQ89	CL004_HUMAN	chromosome 12 open reading frame 4	72										NS(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CTGAGGGATTCTTCTTCTATA	0.423000													11	32					0	0	0.435327	0	0
WDR66	144406	broad.mit.edu	37	12	122413157	122413157	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:122413157G>A	ENST00000288912.4	+	18	3633	c.2779G>A	c.(2779-2781)Gag>Aag	p.E927K		NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	927							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CAGTGTCCTGGAGGCAGCGGT	0.527000													11	39					0	0	0.387290	0	0
TRMT10A	93587	broad.mit.edu	37	4	100475021	100475021	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:100475021T>C	ENST00000273962.3	-	6	878	c.566A>G	c.(565-567)gAt>gGt	p.D189G	TRMT10A_ENST00000394876.2_Missense_Mutation_p.D189G|TRMT10A_ENST00000394877.3_Missense_Mutation_p.D189G	NM_152292.4	NP_689505.1			tRNA methyltransferase 10 homolog A (S. cerevisiae)																		ATTAGGTGAATCTGACGTAAG	0.338000													31	7					0	0	0.750413	0	0
THADA	63892	broad.mit.edu	37	2	43808911	43808911	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:43808911C>T	ENST00000403856.1	-	9	837	c.690G>A	c.(688-690)ttG>ttA	p.L230L	THADA_ENST00000405006.4_Silent_p.L230L|THADA_ENST00000415080.2_5'UTR|THADA_ENST00000405975.2_Silent_p.L230L|THADA_ENST00000402360.2_Silent_p.L230L|THADA_ENST00000404790.1_Silent_p.L230L			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	230							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AAATACTCAGCAATCCACACA	0.328000													8	72					0	0	0.361761	0	0
POLD2	5425	broad.mit.edu	37	7	44157600	44157600	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:44157600C>T	ENST00000406581.2	-	4	933	c.284G>A	c.(283-285)gGc>gAc	p.G95D	POLD2_ENST00000452185.1_Missense_Mutation_p.G95D|POLD2_ENST00000223361.3_Missense_Mutation_p.G95D	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	95					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						GAACAGAGTGCCCACCACACA	0.617000													3	59					0	0	0.115264	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152479	70152479	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:70152479G>C	ENST00000335568.5	+	3	882	c.880G>C	c.(880-882)Gaa>Caa	p.E294Q	UGT2B28_ENST00000511240.1_Missense_Mutation_p.E294Q	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	294					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GGAAATGGAGGAATTTGTACA	0.383000													57	104					0	0	0.870114	0	0
LPL	4023	broad.mit.edu	37	8	19810909	19810909	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:19810909A>T	ENST00000311322.8	+	4	988	c.518A>T	c.(517-519)aAt>aTt	p.N173I		NM_000237.2	NP_000228.1	P06858	LIPL_HUMAN	lipoprotein lipase	173					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	36				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	AGTCTGACCAATAAGAAAGTC	0.413000													29	41					0	0	0.706142	0	0
CD1B	910	broad.mit.edu	37	1	158300658	158300658	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:158300658C>G	ENST00000368168.3	-	2	363	c.256G>C	c.(256-258)Gag>Cag	p.E86Q		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	86					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					CGGAATATCTCCTCTAACTCA	0.458000													79	311					0	0	0.870114	0	0
TTBK1	84630	broad.mit.edu	37	6	43230556	43230556	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:43230556C>T	ENST00000259750.4	+	13	1537	c.1454C>T	c.(1453-1455)tCg>tTg	p.S485L	TTBK1_ENST00000304139.5_Missense_Mutation_p.S434L	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	485						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGCTCGCCCTCGCGCCAGGCC	0.677000													5	4					0	0	0.217242	0	0
ZNF780A	284323	broad.mit.edu	37	19	40582009	40582009	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:40582009C>G	ENST00000450241.2	-	6	549	c.238G>C	c.(238-240)Gag>Cag	p.E80Q	AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000455521.1_Missense_Mutation_p.E115Q|ZNF780A_ENST00000594395.1_Missense_Mutation_p.E115Q|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000340963.5_Missense_Mutation_p.E114Q|ZNF780A_ENST00000595687.2_Missense_Mutation_p.E114Q			O75290	Z780A_HUMAN	zinc finger protein 780A	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E115Q(1)|p.E80Q(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TAAAAGGCCTCAATGCCAAGA	0.328000													35	17					0	0	0.788014	0	0
C7orf60	154743	broad.mit.edu	37	7	112461999	112461999	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:112461999T>C	ENST00000297145.4	-	5	1183	c.1018A>G	c.(1018-1020)Att>Gtt	p.I340V		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	340										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						TCTTGAGGAATATATAACATT	0.353000													4	37					0	0	0.150653	0	0
FAM214A	56204	broad.mit.edu	37	15	52903845	52903845	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:52903845C>T	ENST00000261844.7	-	4	483	c.331G>A	c.(331-333)Gat>Aat	p.D111N	FAM214A_ENST00000546305.2_Missense_Mutation_p.D118N	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	111																	TCATTTAGATCAATTCCCTCT	0.428000													14	39					0	0	0.457914	0	0
VIM	7431	broad.mit.edu	37	10	17278348	17278348	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:17278348G>A	ENST00000544301.1	+	9	1742	c.1329G>A	c.(1327-1329)ctG>ctA	p.L443L	VIM_ENST00000224237.5_Silent_p.L443L	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	443	Tail.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGACACTTCTGATTAAGACGG	0.348000													63	117					0	0	0.870114	0	0
NBPF10	100132406	broad.mit.edu	37	1	145301812	145301812	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:145301812G>A	ENST00000342960.5	+	7	1116	c.1081G>A	c.(1081-1083)Gag>Aag	p.E361K	NBPF10_ENST00000369339.2_Missense_Mutation_p.E90K|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Missense_Mutation_p.E90K	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	361										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAAGCAAGCTGAGGAGCTCAG	0.522000													28	183					0	0	0.804634	0	0
UNC13C	440279	broad.mit.edu	37	15	54914565	54914565	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:54914565T>C	ENST00000545554.1	+	30	6147	c.6147T>C	c.(6145-6147)caT>caC	p.H2049H	UNC13C_ENST00000537900.1_Silent_p.H2047H|UNC13C_ENST00000539562.2_5'UTR|UNC13C_ENST00000260323.11_Silent_p.H2049H			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2049	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATCTGTTCATGTGGACATCA	0.428000													61	18					0	0	0.870114	0	0
DOPEY2	9980	broad.mit.edu	37	21	37650364	37650364	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr21:37650364C>G	ENST00000399151.3	+	29	5889	c.5804C>G	c.(5803-5805)cCa>cGa	p.P1935R		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1935					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TATGTTTTTCCATACTTACGC	0.418000													10	43					0	0	0.387290	0	0
KNDC1	85442	broad.mit.edu	37	10	135020757	135020757	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:135020757C>T	ENST00000304613.3	+	20	3717	c.3696C>T	c.(3694-3696)ctC>ctT	p.L1232L	KNDC1_ENST00000368572.2_Silent_p.L1234L			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1232					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCTCCTCGCTCATCTTCTACA	0.677000													12	60					0	0	0.411799	0	0
MARK4	57787	broad.mit.edu	37	19	45783855	45783855	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:45783855C>T	ENST00000300843.4	+	12	1436	c.1139C>T	c.(1138-1140)cCa>cTa	p.P380L	MARK4_ENST00000262891.4_Missense_Mutation_p.P380L	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	380					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CGGGGCGCCCCAGGGCTGGCC	0.677000													11	49					0	0	0.411799	0	0
RSAD2	91543	broad.mit.edu	37	2	7018158	7018158	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:7018158A>G	ENST00000382040.3	+	1	363	c.227A>G	c.(226-228)aAc>aGc	p.N76S		NM_080657.4	NP_542388.2	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing 2	76					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)	20	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		ACCAGCGTCAACTATCACTTC	0.542000													23	41					0	0	0.654019	0	0
FLNA	2316	broad.mit.edu	37	X	153596026	153596026	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:153596026A>T	ENST00000422373.1	-	4	951	c.703T>A	c.(703-705)Tgg>Agg	p.W235R	FLNA_ENST00000369850.3_Missense_Mutation_p.W235R|FLNA_ENST00000344736.4_Missense_Mutation_p.W235R|FLNA_ENST00000360319.4_Missense_Mutation_p.W235R	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	235	Actin-binding.|CH 2.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGCCCAGCCAGTCATCCGCC	0.657000													60	23					0	0	0.870114	0	0
CA5BP1	340591	broad.mit.edu	37	X	15711112	15711112	+	RNA	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:15711112C>T	ENST00000380334.2	+	0	252																											GGAACGCAGTCAAATTTGAAA	0.398000													14	31					0	0	0.500413	0	0
NCOR1	9611	broad.mit.edu	37	17	16068472	16068472	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:16068472G>A	ENST00000268712.3	-	5	696	c.439C>T	c.(439-441)Cca>Tca	p.P147S	NCOR1_ENST00000395848.1_Missense_Mutation_p.P38S|NCOR1_ENST00000395851.1_Missense_Mutation_p.P147S	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	147	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CCGAATGCTGGATCCTTTAGA	0.393000													8	72					0	0	0.278610	0	0
RMDN2	151393	broad.mit.edu	37	2	38178983	38178983	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:38178983C>A	ENST00000407257.1	+	2	772	c.625C>A	c.(625-627)Caa>Aaa	p.Q209K	RMDN2_ENST00000406384.1_Intron|RMDN2_ENST00000417700.2_Intron|RMDN2-AS1_ENST00000414365.2_RNA|RMDN2_ENST00000402091.3_Missense_Mutation_p.Q209K|RMDN2_ENST00000354545.2_Intron|RMDN2_ENST00000234195.3_Missense_Mutation_p.Q209K					regulator of microtubule dynamics 2																		AGCCTCCTATCAACAAAGCAC	0.368000													29	122					9.39395e-14	1.04592e-13	0.706142	1	0
SLIT2	9353	broad.mit.edu	37	4	20525414	20525414	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:20525414C>T	ENST00000504154.1	+	13	1414	c.1162C>T	c.(1162-1164)Cgg>Tgg	p.R388W	SLIT2_ENST00000503837.1_Missense_Mutation_p.R392W|SLIT2_ENST00000503823.1_Missense_Mutation_p.R388W|SLIT2_ENST00000273739.5_Missense_Mutation_p.R392W	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	388					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AAACTGCCTTCGGGTAGATGC	0.408000													23	78					0	0	0.624587	0	0
OR5H14	403273	broad.mit.edu	37	3	97868318	97868318	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:97868318C>A	ENST00000437310.1	+	1	149	c.89C>A	c.(88-90)gCa>gAa	p.A30E		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CTGTTCCTGGCATTCTTGGTA	0.418000													80	153					2.36867e-37	2.7606e-37	0.870114	1	0
CNGB1	1258	broad.mit.edu	37	16	57973358	57973358	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:57973358C>T	ENST00000564448.1	-	16	1390	c.1330G>A	c.(1330-1332)Gag>Aag	p.E444K	CNGB1_ENST00000564654.1_5'UTR|CNGB1_ENST00000251102.8_Missense_Mutation_p.E450K			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	450					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GCCTCGGCCTCAGCCTCAGGc	0.617000													7	26					0	0	0.278610	0	0
ALDH1A3	220	broad.mit.edu	37	15	101445832	101445832	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:101445832C>G	ENST00000329841.5	+	10	1705	c.1173C>G	c.(1171-1173)ctC>ctG	p.L391L	RP11-66B24.4_ENST00000560351.1_RNA|ALDH1A3_ENST00000346623.6_Silent_p.L284L	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	391					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ACAAGGGGCTCTTCATCAAAC	0.537000													4	26					0	0	0.184627	0	0
SLC2A2	6514	broad.mit.edu	37	3	170725002	170725002	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:170725002C>T	ENST00000314251.3	-	5	626	c.547G>A	c.(547-549)Gct>Act	p.A183T	SLC2A2_ENST00000382808.4_Missense_Mutation_p.A64T	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	183				A -> S (in Ref. 2; BAF83535).	carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			CCCCTGAGAGCGGTTGGAGCA	0.463000													5	24					0	0	0.217242	0	0
TRIM46	80128	broad.mit.edu	37	1	155156625	155156625	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:155156625G>A	ENST00000368382.1	+	10	2307	c.2170G>A	c.(2170-2172)Gag>Aag	p.E724K	TRIM46_ENST00000334634.4_Missense_Mutation_p.E747K|TRIM46_ENST00000545012.1_Missense_Mutation_p.E621K|TRIM46_ENST00000392451.2_3'UTR|TRIM46_ENST00000468878.1_3'UTR	NM_001256599.1|NM_001256600.1|NM_001256601.1|NM_025058.4	NP_001243528.1|NP_001243529.1|NP_001243530.1|NP_079334.3	Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	747	B30.2/SPRY.					intracellular	zinc ion binding	p.E747Q(1)		NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CACTAAGCCTGAGAGGAAAGT	0.642000													5	23					0	0	0.248553	0	0
C9orf131	138724	broad.mit.edu	37	9	35044434	35044434	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:35044434C>T	ENST00000312292.5	+	2	1855	c.1808C>T	c.(1807-1809)cCa>cTa	p.P603L	C9orf131_ENST00000421362.2_Missense_Mutation_p.P555L|C9orf131_ENST00000354479.5_Missense_Mutation_p.P530L	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	603										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TCTAAGCACCCAGCTTGTAAC	0.493000													31	101					0	0	0.740014	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978401	69978401	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:69978401C>G	ENST00000305231.7	+	6	1583	c.1537C>G	c.(1537-1539)Ctg>Gtg	p.L513V	UGT2B7_ENST00000508661.1_3'UTR	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	513					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AAAATGTTGTCTGTTTTGTTT	0.413000													37	46					0	0	0.796494	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51649129	51649129	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:51649129A>C	ENST00000317643.6	+	4	847	c.778A>C	c.(778-780)Aac>Cac	p.N260H	SIGLEC7_ENST00000600577.1_Intron|SIGLEC7_ENST00000305628.7_Missense_Mutation_p.N167H	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	260	Ig-like C2-type 2.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		AGCTCTGGGGAACAGCTCATC	0.517000													19	83					0	0	0.557998	0	0
NTNG1	22854	broad.mit.edu	37	1	107691398	107691398	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:107691398G>A	ENST00000370067.1	+	2	810	c.183G>A	c.(181-183)ctG>ctA	p.L61L	NTNG1_ENST00000370065.1_Silent_p.L61L|NTNG1_ENST00000370066.1_Silent_p.L61L|NTNG1_ENST00000370068.1_Silent_p.L61L|NTNG1_ENST00000370070.2_Silent_p.L61L|NTNG1_ENST00000370072.3_Silent_p.L61L|NTNG1_ENST00000370073.2_Silent_p.L61L|NTNG1_ENST00000370074.4_Silent_p.L61L|NTNG1_ENST00000370061.3_Silent_p.L61L|NTNG1_ENST00000542803.1_Silent_p.L61L|NTNG1_ENST00000370071.2_Silent_p.L61L			Q9Y2I2	NTNG1_HUMAN	netrin G1	61	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CAAAATATCTGAAAGTGAAAC	0.423000													21	96					0	0	0.624587	0	0
ZNF812	729648	broad.mit.edu	37	19	9800941	9800941	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:9800941C>T	ENST00000457674.2	-	5	1756	c.1238G>A	c.(1237-1239)aGa>aAa	p.R413K	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGCTTTCTCTCTGGTATGAGT	0.413000													9	26					0	0	0.335167	0	0
PPAN	56342	broad.mit.edu	37	19	10221801	10221801	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:10221801G>A	ENST00000253107.7	+	12	1488	c.1382G>A	c.(1381-1383)cGa>cAa	p.R461Q	PPAN-P2RY11_ENST00000428358.1_Intron|PPAN_ENST00000556468.1_Intron|PPAN_ENST00000393793.1_Missense_Mutation_p.R408Q|PPAN-P2RY11_ENST00000393796.4_Intron	NM_020230.5	NP_064615.3			peter pan homolog (Drosophila)											endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GATGGTGGGCGAGGCCGGGGC	0.697000													4	7					0	0	0.150653	0	0
NYAP2	57624	broad.mit.edu	37	2	226446903	226446903	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:226446903G>A	ENST00000272907.6	+	4	1183	c.770G>A	c.(769-771)aGg>aAg	p.R257K	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	257																	AGAGACTTCAGGAAGGAGGAC	0.577000													50	69					0	0	0.870114	0	0
DCDC2B	149069	broad.mit.edu	37	1	32677785	32677785	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:32677785G>C	ENST00000409358.1	+	4	510	c.510G>C	c.(508-510)caG>caC	p.Q170H		NM_001099434.1	NP_001092904.1	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	170	Doublecortin 2.				intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TCAAGTTGCAGAGTGGGGCTG	0.577000													8	87					0	0	0.307466	0	0
HGS	9146	broad.mit.edu	37	17	79667588	79667588	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79667588C>T	ENST00000329138.4	+	19	2109	c.1974C>T	c.(1972-1974)ccC>ccT	p.P658P		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	658	Gln-rich.|Interaction with NF2.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding	p.P658P(1)		endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			CCGCCAGCCCCGCTTACTCAT	0.692000													54	7					0	0	0.870114	0	0
C6orf195	154386	broad.mit.edu	37	6	2623874	2623874	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:2623874G>A	ENST00000296847.3	-	3	706	c.183C>T	c.(181-183)ccC>ccT	p.P61P		NM_152554.2	NP_689767.2	Q96MT4	CF195_HUMAN	chromosome 6 open reading frame 195	61								p.P61P(2)		cervix(1)|endometrium(1)|lung(2)|skin(1)	5	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				GGCCGGACCCGGGAGGGGAGA	0.632000													46	73					0	0	0.870114	0	0
TSPY2	64591	broad.mit.edu	37	Y	6115622	6115622	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrY:6115622G>C	ENST00000320701.4	+	3	630	c.584G>C	c.(583-585)cGt>cCt	p.R195P	TSPY2_ENST00000383042.1_Missense_Mutation_p.R195P	NM_022573.2	NP_072095.2	A6NKD2	TSPY2_HUMAN	testis specific protein, Y-linked 2	195					cell differentiation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus				liver(1)|lung(4)|prostate(1)|skin(1)	7						GAGAAGCATCGTGTTCATCTC	0.443000													4	92					0	0	0.150653	0	0
CENPN	55839	broad.mit.edu	37	16	81061821	81061821	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:81061821G>A	ENST00000305850.5	+	10	1646	c.856G>A	c.(856-858)Gag>Aag	p.E286K	RP11-303E16.3_ENST00000566390.1_RNA|CENPN_ENST00000428963.2_Missense_Mutation_p.E252K|CENPN_ENST00000439957.3_Missense_Mutation_p.E266K|RP11-303E16.3_ENST00000561808.1_RNA|CENPN_ENST00000393335.3_Missense_Mutation_p.E286K	NM_001100624.2|NM_001270474.1	NP_001094094.2|NP_001257403.1	Q96H22	CENPN_HUMAN	centromere protein N	286					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm				breast(1)|large_intestine(5)|lung(4)	10						CATCTTGGCTGAGAGGGAAGA	0.403000													11	49					0	0	0.411799	0	0
LGR6	59352	broad.mit.edu	37	1	202287786	202287786	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:202287786C>G	ENST00000367278.3	+	18	2444	c.2355C>G	c.(2353-2355)ctC>ctG	p.L785L	LGR6_ENST00000439764.2_Silent_p.L646L|LGR6_ENST00000255432.7_Silent_p.L733L	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	785						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						ACGGGCTCCTCTACTGTCCCG	0.647000													13	77					0	0	0.435327	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	73					0	0	0.150653	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18753314	18753314	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:18753314G>A	ENST00000380548.4	+	16	2364	c.2025G>A	c.(2023-2025)tgG>tgA	p.W675*		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	675	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TTGGCAAGTGGAGTCCATGTA	0.488000													10	2					0	0	0.361761	0	0
ZNF516	9658	broad.mit.edu	37	18	74154474	74154474	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:74154474G>A	ENST00000443185.2	-	3	854	c.537C>T	c.(535-537)tgC>tgT	p.C179C	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ACTGGCTCTTGCAGAAGGAGC	0.672000													4	19					0	0	0.217242	0	0
CLTC	1213	broad.mit.edu	37	17	57768080	57768080	+	Silent	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:57768080C>G	ENST00000393043.1	+	31	5185	c.4911C>G	c.(4909-4911)ctC>ctG	p.L1637L	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000269122.3_Intron			Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1637	Heavy chain arm.|Proximal segment.|Trimerization (By similarity).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					ATGGTAATCTCTCTCTGTAAC	0.343000			T	"""ALK, TFE3"""	"""ALCL, renal """								8	53					0	0	0.307466	0	0
GRIK5	2901	broad.mit.edu	37	19	42557775	42557775	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:42557775G>A	ENST00000262895.3	-	10	1247	c.1248C>T	c.(1246-1248)acC>acT	p.T416T	GRIK5_ENST00000301218.4_Silent_p.T416T|GRIK5_ENST00000593562.1_Silent_p.T416T	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	416						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TGACCACCAGGGTCTTGTTGG	0.622000													11	32					0	0	0.387290	0	0
ZNF239	8187	broad.mit.edu	37	10	44052584	44052584	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:44052584C>G	ENST00000306006.6	-	2	1596	c.944G>C	c.(943-945)gGa>gCa	p.G315A	ZNF239_ENST00000374446.2_Missense_Mutation_p.G315A|ZNF239_ENST00000426961.1_Missense_Mutation_p.G315A|ZNF239_ENST00000535642.1_Missense_Mutation_p.G315A	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GGGCTTCTCTCCAGTGTGGAC	0.522000													15	68					0	0	0.457914	0	0
PTPRD	5789	broad.mit.edu	37	9	8471058	8471058	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:8471058C>G	ENST00000381196.4	-	28	3984	c.3441G>C	c.(3439-3441)ttG>ttC	p.L1147F	PTPRD_ENST00000356435.5_Missense_Mutation_p.L1147F|PTPRD_ENST00000486161.1_Missense_Mutation_p.L736F|PTPRD_ENST00000397611.3_Missense_Mutation_p.L733F|PTPRD_ENST00000358503.5_Missense_Mutation_p.L1125F|PTPRD_ENST00000540109.1_Missense_Mutation_p.L1147F|PTPRD_ENST00000360074.4_Missense_Mutation_p.L1134F|PTPRD_ENST00000537002.1_Missense_Mutation_p.L733F|PTPRD_ENST00000397617.3_Missense_Mutation_p.L726F|PTPRD_ENST00000397606.3_Missense_Mutation_p.L726F|PTPRD_ENST00000355233.5_Missense_Mutation_p.L736F	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1147					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAGATTTCTTCAAAGGCACAA	0.378000										TSP Lung(15;0.13)			40	18					0	0	0.840704	0	0
QKI	9444	broad.mit.edu	37	6	163984469	163984469	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:163984469C>G	ENST00000361752.3	+	6	1203	c.652C>G	c.(652-654)Ctt>Gtt	p.L218V	QKI_ENST00000424802.3_Intron|QKI_ENST00000392127.2_Missense_Mutation_p.L218V|QKI_ENST00000275262.7_Missense_Mutation_p.L218V|QKI_ENST00000453779.2_Missense_Mutation_p.L218V|QKI_ENST00000361195.2_Intron	NM_006775.2|NM_206853.2|NM_206854.2|NM_206855.2	NP_006766.1|NP_996735.1|NP_996736.1|NP_996737.1	Q96PU8	QKI_HUMAN	QKI, KH domain containing, RNA binding	218					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(5)|ovary(1)|prostate(3)|urinary_tract(2)	27		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TGCCTTTTCTCTTGCAGCAAC	0.498000													3	20					0	0	0.115264	0	0
ITGA10	8515	broad.mit.edu	37	1	145536002	145536002	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:145536002G>C	ENST00000369304.3	+	17	2269	c.2094G>C	c.(2092-2094)atG>atC	p.M698I	ITGA10_ENST00000539363.1_Missense_Mutation_p.M555I|ITGA10_ENST00000538811.1_Missense_Mutation_p.M567I	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	698					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATTCAGACATGAGGTTCACCG	0.542000													30	108					0	0	0.769981	0	0
EIF3L	51386	broad.mit.edu	37	22	38270460	38270460	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:38270460C>T	ENST00000412331.2	+	9	1417	c.835C>T	c.(835-837)Cgc>Tgc	p.R279C	EIF3L_ENST00000381683.6_Missense_Mutation_p.R231C|EIF3L_ENST00000406934.1_Missense_Mutation_p.R181C	NM_016091.3	NP_057175.1	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3, subunit L	279						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			kidney(2)|large_intestine(3)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CGGGCTTCTCCGCCTGCACTC	0.547000													44	19					0	0	0.834066	0	0
FGF20	26281	broad.mit.edu	37	8	16850824	16850824	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:16850824C>G	ENST00000180166.5	-	3	541	c.393G>C	c.(391-393)gaG>gaC	p.E131D		NM_019851.2	NP_062825.1	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	131					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity	p.E131E(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	11				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		AAGTAAGTTTCTCCTGAAAGA	0.333000													45	132					0	0	0.870114	0	0
SPEG	10290	broad.mit.edu	37	2	220309817	220309817	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:220309817C>T	ENST00000312358.7	+	3	881	c.749C>T	c.(748-750)tCc>tTc	p.S250F	SPEG_ENST00000396695.2_Intron|SPEG_ENST00000396698.1_Missense_Mutation_p.S146F	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	250					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GATAGCCTTTCCGTGGCCAGT	0.652000													4	8					0	0	0.150653	0	0
PDZD2	23037	broad.mit.edu	37	5	32037403	32037403	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:32037403C>G	ENST00000438447.1	+	7	1862	c.1474C>G	c.(1474-1476)Ccc>Gcc	p.P492A	PDZD2_ENST00000282493.3_Missense_Mutation_p.P492A			O15018	PDZD2_HUMAN	PDZ domain containing 2	492					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CTTGGAAAGTCCCAAACAGGG	0.522000													6	78					0	0	0.307466	0	0
NCAPG	64151	broad.mit.edu	37	4	17829921	17829921	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:17829921G>C	ENST00000251496.2	+	12	1850	c.1674G>C	c.(1672-1674)caG>caC	p.Q558H		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	558					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		AAACATTGCAGAAATGTCTTA	0.348000													17	32					0	0	0.539581	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369500	86369500	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:86369500C>A	ENST00000400286.2	-	2	1742	c.1144G>T	c.(1144-1146)Gat>Tat	p.D382Y		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	382						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCCACTAGATCAGACTTCATT	0.378000													32	46					1.06801e-11	1.17699e-11	0.740014	1	0
TGIF1	7050	broad.mit.edu	37	18	3456381	3456381	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:3456381G>C	ENST00000343820.5	+	2	832	c.46G>C	c.(46-48)Gag>Cag	p.E16Q	TGIF1_ENST00000551402.1_Missense_Mutation_p.E16Q|TGIF1_ENST00000405385.3_5'UTR|TGIF1_ENST00000401449.1_5'UTR|TGIF1_ENST00000548489.2_Missense_Mutation_p.E30Q|TGIF1_ENST00000472042.1_5'UTR|TGIF1_ENST00000400167.2_5'UTR|TGIF1_ENST00000345133.5_5'UTR|TGIF1_ENST00000330513.5_Missense_Mutation_p.E145Q|TGIF1_ENST00000407501.2_Missense_Mutation_p.E16Q|TGIF1_ENST00000577543.1_Missense_Mutation_p.E16Q|TGIF1_ENST00000551541.1_5'UTR	NM_003244.3	NP_003235.1	Q15583	TGIF1_HUMAN	TGFB-induced factor homeobox 1	145					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.E145Q(1)		cervix(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13	Esophageal squamous(4;0.0859)	Colorectal(8;0.0104)				CAGTGAGACTGAGGATGAGGA	0.502000													6	563					0	0	0.217242	0	0
STIP1	10963	broad.mit.edu	37	11	63965417	63965417	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:63965417A>G	ENST00000358794.5	+	8	1688	c.1135A>G	c.(1135-1137)Acc>Gcc	p.T379A	STIP1_ENST00000538945.1_Missense_Mutation_p.T308A|STIP1_ENST00000305218.4_Missense_Mutation_p.T332A			P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	332					axon guidance|response to stress	Golgi apparatus|nucleus				endometrium(4)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(1)|skin(1)	27						AGAGCACCGAACCCCAGATGT	0.403000													5	155					0	0	0.184627	0	0
NSD1	64324	broad.mit.edu	37	5	176618931	176618931	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:176618931A>T	ENST00000439151.2	+	3	1019	c.974A>T	c.(973-975)gAt>gTt	p.D325V	NSD1_ENST00000347982.4_Missense_Mutation_p.D56V|NSD1_ENST00000361032.4_Intron|NSD1_ENST00000354179.4_Missense_Mutation_p.D56V	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	325	PWWP 1.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GAAGTTGGAGATCTCATCTGG	0.388000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			41	16					0	0	0.847076	0	0
EPHA5	2044	broad.mit.edu	37	4	66361186	66361186	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:66361186T>A	ENST00000273854.3	-	4	1586	c.986A>T	c.(985-987)cAt>cTt	p.H329L	EPHA5_ENST00000511294.1_Missense_Mutation_p.H329L|EPHA5_ENST00000354839.4_Missense_Mutation_p.H329L|EPHA5_ENST00000432638.2_Intron	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	329	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						AGCTTCCTCATGGGTATAACT	0.463000										TSP Lung(17;0.13)			39	74					0	0	0.834066	0	0
EIF3B	8662	broad.mit.edu	37	7	2412331	2412331	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:2412331G>A	ENST00000360876.4	+	12	1767	c.1711G>A	c.(1711-1713)Gaa>Aaa	p.E571K	EIF3B_ENST00000397011.2_Missense_Mutation_p.E571K	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	571					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTTTGCCTGGGAACCAAATGG	0.438000													11	24					0	0	0.435327	0	0
ATP11A	23250	broad.mit.edu	37	13	113439521	113439521	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:113439521G>C	ENST00000487903.1	+	2	200	c.112G>C	c.(112-114)Gag>Cag	p.E38Q	ATP11A_ENST00000375630.2_Missense_Mutation_p.E38Q|ATP11A_ENST00000375645.3_Missense_Mutation_p.E38Q|ATP11A_ENST00000283558.8_Missense_Mutation_p.E38Q			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	38					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCCGGGCGCAGAGGCCTACAT	0.557000											OREG0003855	type=REGULATORY REGION|Gene=ATP11A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	74					0	0	0.520397	0	0
IL3RA	3563	broad.mit.edu	37	X	1471251	1471251	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:1471251G>A	ENST00000331035.4	+	6	817	c.468G>A	c.(466-468)acG>acA	p.T156T	IL3RA_ENST00000381469.2_Silent_p.T78T	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	156						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACTACAAAACGGATGCTCAGG	0.602000													86	151					0	0	0.870114	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790784	133790784	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:133790784G>C	ENST00000321016.8	-	18	3066	c.2836C>G	c.(2836-2838)Cgg>Ggg	p.R946G	IGSF9B_ENST00000533871.2_Missense_Mutation_p.R946G			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	946	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCCTGAAGCCGACCTTCCAGG	0.697000													14	25					0	0	0.479597	0	0
HGF	3082	broad.mit.edu	37	7	81355326	81355326	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:81355326G>A	ENST00000222390.5	-	9	1274	c.1048C>T	c.(1048-1050)Cga>Tga	p.R350*	HGF_ENST00000457544.2_Nonsense_Mutation_p.R345*	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	350	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TAATTTTCTCGTAGGTCCCTA	0.418000													19	47					0	0	0.557998	0	0
CXXC1	30827	broad.mit.edu	37	18	47812911	47812911	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:47812911C>G	ENST00000285106.6	-	3	935	c.221G>C	c.(220-222)aGa>aCa	p.R74T	CXXC1_ENST00000589940.1_Missense_Mutation_p.R74T|CXXC1_ENST00000412036.2_Missense_Mutation_p.R74T|CXXC1_ENST00000587396.1_5'UTR	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	74					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						GCCCTCACCTCTGCACTCCCG	0.592000													20	43					0	0	0.592651	0	0
CDH10	1008	broad.mit.edu	37	5	24535254	24535254	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:24535254C>T	ENST00000264463.4	-	5	1288	c.781G>A	c.(781-783)Gat>Aat	p.D261N		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	261	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TCATTGACATCTGTCAGCGTG	0.478000										HNSCC(23;0.051)			8	135					0	0	0.361761	0	0
POPDC3	64208	broad.mit.edu	37	6	105606561	105606561	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:105606561G>A	ENST00000254765.3	-	4	938	c.660C>T	c.(658-660)ctC>ctT	p.L220L	BVES-AS1_ENST00000369120.2_RNA|BVES-AS1_ENST00000369122.3_RNA|BVES-AS1_ENST00000580854.1_RNA|BVES-AS1_ENST00000580511.1_RNA|POPDC3_ENST00000474760.1_5'UTR	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	220						integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GCTGAGCAAAGAGCAGATATA	0.408000													46	89					0	0	0.859065	0	0
PAG1	55824	broad.mit.edu	37	8	81899630	81899630	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:81899630C>T	ENST00000220597.4	-	6	959	c.249G>A	c.(247-249)caG>caA	p.Q83Q		NM_018440.3	NP_060910.3	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid microdomains 1	83					epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(2)	11	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GTGCCCCATTCTGCTCACTGC	0.458000													12	62					0	0	0.411799	0	0
MAB21L1	4081	broad.mit.edu	37	13	36050182	36050182	+	Silent	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:36050182G>T	ENST00000379919.4	-	1	650	c.94C>A	c.(94-96)Cgg>Agg	p.R32R	NBEA_ENST00000540320.1_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000310336.4_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	32					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CAGACTTCCCGGATAGTTTTG	0.512000													18	73					1.37657e-19	1.56494e-19	0.608945	1	0
ECM2	1842	broad.mit.edu	37	9	95256393	95256393	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:95256393C>T	ENST00000444490.2	-	10	1970	c.1904G>A	c.(1903-1905)aGa>aAa	p.R635K	CENPP_ENST00000375587.3_Intron	NM_001197296.1	NP_001184225.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	0					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						CACATCTGATCTGTTTGTCAC	0.413000													11	60					0	0	0.479597	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664091	44664091	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:44664091G>A	ENST00000454036.1	+	3	341	c.265G>A	c.(265-267)Gcc>Acc	p.A89T	SLC12A5_ENST00000372315.1_Missense_Mutation_p.A66T|SLC12A5_ENST00000539566.1_Missense_Mutation_p.A66T|SLC12A5_ENST00000243964.3_Missense_Mutation_p.A66T	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	89					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAGTGGCCTGGCCAACTACAC	0.587000													5	192					0	0	0.184627	0	0
TRAPPC8	22878	broad.mit.edu	37	18	29450923	29450923	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:29450923T>C	ENST00000283351.4	-	15	2558	c.2223A>G	c.(2221-2223)tcA>tcG	p.S741S	TRAPPC8_ENST00000582539.1_Silent_p.S687S	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	741					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTGAATTATCTGAGTAACTGT	0.328000													9	9					0	0	0.335167	0	0
CCDC80	151887	broad.mit.edu	37	3	112358039	112358039	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:112358039C>T	ENST00000206423.3	-	2	1667	c.714G>A	c.(712-714)ctG>ctA	p.L238L	CCDC80_ENST00000439685.2_Silent_p.L238L	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	238										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						GCGTCTTCTTCAGCAGCACCA	0.582000													20	108					0	0	0.557998	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056153	26056153	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:26056153C>G	ENST00000343677.2	-	1	546	c.504G>C	c.(502-504)aaG>aaC	p.K168N		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	168					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						TAGCCACTTTCTTGGTTACAG	0.572000													61	27					0	0	0.870114	0	0
MICAL3	57553	broad.mit.edu	37	22	18387474	18387474	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18387474G>A	ENST00000441493.2	-	3	748	c.396C>T	c.(394-396)ttC>ttT	p.F132F	MICAL3_ENST00000207726.7_Silent_p.F132F|MICAL3_ENST00000383094.3_Silent_p.F132F|MICAL3_ENST00000585038.1_Silent_p.F132F|MICAL3_ENST00000429452.1_Silent_p.F132F|MICAL3_ENST00000444520.1_Silent_p.F132F|MICAL3_ENST00000414725.2_Silent_p.F132F|MICAL3_ENST00000400561.2_Silent_p.F132F	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	132						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CATGTATGGTGAATGGCCAGA	0.483000													32	91					0	0	0.769981	0	0
FAM154A	158297	broad.mit.edu	37	9	18928327	18928327	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:18928327G>T	ENST00000380534.4	-	4	1427	c.1148C>A	c.(1147-1149)cCt>cAt	p.P383H	FAM154A_ENST00000542071.1_Missense_Mutation_p.P191H|FAM154A_ENST00000380530.1_3'UTR	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	383										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		GGTATTGATAGGCAGGTGGGG	0.582000													8	33					0.000157383	0.000163436	0.278610	1	0
LOX	4015	broad.mit.edu	37	5	121411146	121411146	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:121411146G>A	ENST00000231004.4	-	3	1130	c.831C>T	c.(829-831)ttC>ttT	p.F277F	LOX_ENST00000513319.1_5'UTR|SRFBP1_ENST00000504881.1_3'UTR	NM_001178102.1|NM_002317.5	NP_001171573.1|NP_002308.2	P28300	LYOX_HUMAN	lysyl oxidase	277	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			endometrium(1)|lung(6)|prostate(1)	8		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		GGCTGGGTAAGAAATCTGATG	0.453000													13	75					0	0	0.457914	0	0
NCOR2	9612	broad.mit.edu	37	12	124812114	124812114	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:124812114T>C	ENST00000356219.3	-	46	7200	c.7045A>G	c.(7045-7047)Ata>Gta	p.I2349V	NCOR2_ENST00000429285.2_Missense_Mutation_p.I2332V|NCOR2_ENST00000405201.1_Missense_Mutation_p.I2342V|NCOR2_ENST00000404621.1_Missense_Mutation_p.I2332V|NCOR2_ENST00000404121.2_Missense_Mutation_p.I1903V|NCOR2_ENST00000397355.1_Missense_Mutation_p.I2333V	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2353					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTTCTAATTATGGCCTCCAGC	0.547000													16	23					0	0	0.539581	0	0
KMT2D	8085	broad.mit.edu	37	12	49433388	49433388	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:49433388G>A	ENST00000301067.7	-	32	8058	c.8059C>T	c.(8059-8061)Cga>Tga	p.R2687*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.R2417*(1)|p.R2687*(1)									AGCAGCTCTCGTAGTCGCTGG	0.572000													10	15					0	0	0.387290	0	0
CCDC105	126402	broad.mit.edu	37	19	15132719	15132719	+	Silent	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:15132719G>A	ENST00000292574.3	+	6	1321	c.1239G>A	c.(1237-1239)gcG>gcA	p.A413A		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	413					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CGGAGGCTGCGCGCCTCGCAC	0.617000													26	16					0	0	0.681144	0	0
ZNF281	23528	broad.mit.edu	37	1	200377873	200377873	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:200377873G>A	ENST00000294740.2	-	2	1085	c.961C>T	c.(961-963)Cag>Tag	p.Q321*	ZNF281_ENST00000367352.3_Nonsense_Mutation_p.Q285*|ZNF281_ENST00000367353.1_Nonsense_Mutation_p.Q321*	NM_012482.3	NP_036614.1	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	321					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	27						ATGCTGCACTGATCACATCCA	0.403000													117	171					0	0	0.870114	0	0
C9orf131	138724	broad.mit.edu	37	9	35044709	35044709	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:35044709C>G	ENST00000312292.5	+	2	2130	c.2083C>G	c.(2083-2085)Cta>Gta	p.L695V	C9orf131_ENST00000421362.2_Missense_Mutation_p.L647V|C9orf131_ENST00000354479.5_Missense_Mutation_p.L622V	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	695										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTCTACTCCTCTACCAGAGCC	0.562000													13	30					0	0	0.411799	0	0
BAZ2B	29994	broad.mit.edu	37	2	160206345	160206345	+	Silent	SNP	T	T	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:160206345T>C	ENST00000392783.2	-	28	5232	c.4737A>G	c.(4735-4737)tcA>tcG	p.S1579S	BAZ2B_ENST00000355831.2_Silent_p.S1545S|BAZ2B_ENST00000343439.5_Silent_p.S1479S|BAZ2B_ENST00000392782.1_Silent_p.S1543S	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						AAGAAGCAGTTGACATATCGG	0.453000													46	75					0	0	0.864702	0	0
ATXN2L	11273	broad.mit.edu	37	16	28844640	28844640	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:28844640C>T	ENST00000336783.4	+	14	2087	c.1920C>T	c.(1918-1920)atC>atT	p.I640I	RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000570200.1_Silent_p.I640I|ATXN2L_ENST00000564304.1_Silent_p.I646I|ATXN2L_ENST00000565845.1_3'UTR|ATXN2L_ENST00000382686.4_Silent_p.I640I|ATXN2L_ENST00000340394.8_Silent_p.I640I|ATXN2L_ENST00000395547.2_Silent_p.I640I|ATXN2L_ENST00000325215.6_Silent_p.I640I	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	640						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						TGGGCCTCATCAAGGGAGAAG	0.622000													18	46					0	0	0.592651	0	0
TTC7A	57217	broad.mit.edu	37	2	47278983	47278983	+	Silent	SNP	C	C	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:47278983C>T	ENST00000319190.5	+	18	2484	c.2116C>T	c.(2116-2118)Ctg>Ttg	p.L706L	TTC7A_ENST00000409245.1_Silent_p.L672L|TTC7A_ENST00000394850.2_Silent_p.L730L|TTC7A_ENST00000263737.6_Silent_p.L352L	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	706							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CCCCATGCAGCTGTGGACCAC	0.657000													18	15					0	0	0.539581	0	0
HEYL	26508	broad.mit.edu	37	1	40092678	40092678	+	Missense_Mutation	SNP	G	G	A	rs139668981	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:40092678G>A	ENST00000372852.3	-	5	807	c.488C>T	c.(487-489)tCg>tTg	p.S163L	HEYL_ENST00000535435.1_Missense_Mutation_p.S135L	NM_014571.3	NP_055386.1	Q9NQ87	HEYL_HUMAN	hes-related family bHLH transcription factor with YRPW motif-like	163	Pro-rich.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GGGCGTGGGCGAAGGCTCCAT	0.652000													15	36					0	0	0.457914	0	0
KIF19	124602	broad.mit.edu	37	17	72348997	72348997	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:72348997C>G	ENST00000389916.4	+	15	2156	c.2018C>G	c.(2017-2019)tCa>tGa	p.S673*		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	673					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GCAGGAACCTCACTGACCCCA	0.567000													17	91					0	0	0.539581	0	0
HTR7	3363	broad.mit.edu	37	10	92508597	92508597	+	Splice_Site	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:92508597G>A	ENST00000371721.3	-	2	1536	c.1295_splice	c.e2+1	p.L432_splice	HTR7_ENST00000336152.3_Splice_Site_p.L432_splice|HTR7_ENST00000371719.2_Silent_p.L432L|HTR7_ENST00000277874.6_Splice_Site_p.L432_splice			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	432					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TGACCTTACAGCACAAACTCA	0.483000													45	108					0	0	0.859065	0	0
EPHA3	2042	broad.mit.edu	37	3	89498433	89498433	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:89498433C>G	ENST00000336596.2	+	14	2630	c.2405C>G	c.(2404-2406)aCg>aGg	p.T802R	EPHA3_ENST00000494014.1_Missense_Mutation_p.T802R	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	802	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGCAAGTTCACGTCAGCCAGC	0.438000										TSP Lung(6;0.00050)			50	65					0	0	0.870114	0	0
NMT1	4836	broad.mit.edu	37	17	43159057	43159057	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:43159057G>C	ENST00000592782.1	+	3	308	c.177G>C	c.(175-177)aaG>aaC	p.K59N	NMT1_ENST00000258960.2_Missense_Mutation_p.K59N|NMT1_ENST00000590114.1_3'UTR			P30419	NMT1_HUMAN	N-myristoyltransferase 1	59	Poly-Lys.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				agaagaaaaagaaacaaaaaa	0.378000													5	28					0	0	0.184627	0	0
PRDM1	639	broad.mit.edu	37	6	106547390	106547390	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:106547390C>G	ENST00000369096.4	+	4	861	c.627C>G	c.(625-627)caC>caG	p.H209Q	PRDM1_ENST00000369091.2_Missense_Mutation_p.H173Q|PRDM1_ENST00000369089.3_Missense_Mutation_p.H75Q	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	209					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AAAGGCTTCACTACCCTTATC	0.443000			"""D, N, Mis, F, S"""		DLBCL								16	5					0	0	0.520397	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													8	124					0	0	0.307466	0	0
CUBN	8029	broad.mit.edu	37	10	17147564	17147564	+	Silent	SNP	A	A	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:17147564A>T	ENST00000377833.4	-	11	1187	c.1122T>A	c.(1120-1122)ccT>ccA	p.P374P		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	374	EGF-like 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACGTGCAGAGAGGTAAGGAAC	0.443000													19	28					0	0	0.539581	0	0
TGS1	96764	broad.mit.edu	37	8	56698298	56698298	+	Missense_Mutation	SNP	G	G	C	rs139226926	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:56698298G>C	ENST00000260129.5	+	3	664	c.187G>C	c.(187-189)Gag>Cag	p.E63Q		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	63					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GACAGAAGAAGAGGAAGGTGG	0.408000													10	37					0	0	0.335167	0	0
OR8H2	390151	broad.mit.edu	37	11	55872567	55872567	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:55872567G>A	ENST00000313503.1	+	1	49	c.49G>A	c.(49-51)Gga>Aga	p.G17R		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G17I(1)|p.G17*(1)|p.G17R(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					CATCCTTATGGGACTGACACT	0.423000										HNSCC(53;0.14)			28	124					0	0	0.750413	0	0
PTCD3	55037	broad.mit.edu	37	2	86361419	86361419	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:86361419T>G	ENST00000254630.7	+	20	1614	c.1548T>G	c.(1546-1548)agT>agG	p.S516R		NM_017952.5	NP_060422.4	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3	516						mitochondrion	protein binding			NS(1)|breast(2)|endometrium(3)|kidney(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	22						TTCAAGATAGTAAAGAATATG	0.408000													12	26					0	0	0.411799	0	0
COL11A1	1301	broad.mit.edu	37	1	103480096	103480096	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:103480096G>A	ENST00000358392.2	-	13	1896	c.1579C>T	c.(1579-1581)Cag>Tag	p.Q527*	COL11A1_ENST00000512756.1_Nonsense_Mutation_p.Q399*|COL11A1_ENST00000353414.4_Nonsense_Mutation_p.Q476*|COL11A1_ENST00000370096.3_Nonsense_Mutation_p.Q515*	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	515	Telopeptide.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTTGAGCCTGAGCTTCCTGA	0.418000													7	33					0	0	0.248553	0	0
NPHP4	261734	broad.mit.edu	37	1	5993234	5993237	+	Frame_Shift_Del	DEL	TACC	TACC	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:5993234_5993237delTACC	ENST00000378156.4	-	10	1537_1540	c.1272_1275delGGTA	c.(1270-1275)aafs	p.KV424fs	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	424					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCTGAGGGTACCTTGTAGACCA	0.500													22	75	---	---	---	---					
ARID1A	8289	broad.mit.edu	37	1	27100182	27100184	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:27100182_27100184delGCA	ENST00000324856.7	+	16	4349_4351	c.3978_3980delGCA	c.(3976-3981)ccg>cc	p.PQ1326del	ARID1A_ENST00000374152.2_In_Frame_Del_p.PQ943del|ARID1A_ENST00000540690.1_5'UTR|ARID1A_ENST00000457599.2_In_Frame_Del_p.PQ1326del	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1326					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Q1327*(1)|p.Q1334delQ(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCTACCCCCCgcagcagcagcag	0.591			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	117	---	---	---	---					
FAM163A	148753	broad.mit.edu	37	1	179783092	179783093	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:179783092_179783093delCC	ENST00000341785.4	+	5	668_669	c.272_273delCC	c.(271-273)gfs	p.A92fs		NM_173509.2	NP_775780.1	Q96GL9	F163A_HUMAN	family with sequence similarity 163, member A	92						integral to membrane				endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)	15						TGTGGGGTGGCCGCGAGCCACT	0.663													14	47	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179458509	179458510	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179458509_179458510insT	ENST00000589042.1	-	298	58741_58742	c.58517_58518insA	c.(58516-58518)ggafs	p.G19506fs	TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Frame_Shift_Ins_p.G17865fs|TTN_ENST00000460472.2_Frame_Shift_Ins_p.G10441fs|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Frame_Shift_Ins_p.G10633fs|TTN_ENST00000359218.5_Frame_Shift_Ins_p.G10566fs|TTN_ENST00000342992.6_Frame_Shift_Ins_p.G16938fs|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17865	Fibronectin type-III 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCTCCATCATCTAAAGGAGG	0.416													19	41	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179616191	179616192	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179616191_179616192insT	ENST00000360870.5	-	46	11157_11158	c.10935_10936insA	c.(10933-10938)aaaagafs	p.R3646fs	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9491	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCACATCTTGTTTTTTGTTAA	0.371													47	95	---	---	---	---					
C2orf83	56918	broad.mit.edu	37	2	228476153	228476165	+	Frame_Shift_Del	DEL	TCTTGTGGCTTCT	TCTTGTGGCTTCT	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:228476153_228476165delTCTTGTGGCTTCT	ENST00000264387.4	-	3	484_496	c.398_410delAGAAGCCACAAGA	c.(397-411)atfs	p.KKPQD133fs	C2orf83_ENST00000409066.1_3'UTR	NM_020161.3	NP_064546.3	Q53S99	CB083_HUMAN	chromosome 2 open reading frame 83	133						membrane	folic acid binding|reduced folate carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(2)	11						GAGCACCGAATCTTGTGGCTTCTTGTTCTCTGT	0.493													9	89	---	---	---	---					
LYAR	55646	broad.mit.edu	37	4	4270287	4270287	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:4270287delA	ENST00000343470.4	-	9	1215	c.975delT	c.(973-975)aafs	p.N325fs	LYAR_ENST00000452476.1_Frame_Shift_Del_p.N325fs	NM_017816.2	NP_060286.1	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive	325	Lys-rich.					nucleolus	metal ion binding|protein binding			endometrium(2)|large_intestine(6)|liver(2)|lung(5)|ovary(1)|prostate(1)	17				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGGTTATTTCATTGTCTGGGG	0.333													10	100	---	---	---	---					
HIST1H1C	3006	broad.mit.edu	37	6	26056548	26056549	+	Frame_Shift_Ins	INS	-	-	A	rs10425	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:26056548_26056549insA	ENST00000343677.2	-	1	150_151	c.108_109insT	c.(106-111)tcgtccfs	p.S37fs		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	37	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						ACCGGGGGACCAGACGCCTTAC	0.634													39	15	---	---	---	---					
POR	5447	broad.mit.edu	37	7	75612906	75612907	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:75612906_75612907insG	ENST00000394893.1	+	9	919_920	c.899_900insG	c.(898-900)gcgfs	p.A300fs	POR_ENST00000545601.1_Frame_Shift_Ins_p.A108fs|POR_ENST00000439269.1_Frame_Shift_Ins_p.A38fs|POR_ENST00000419840.1_Frame_Shift_Ins_p.A114fs|POR_ENST00000461988.1_Frame_Shift_Ins_p.A300fs|POR_ENST00000450476.1_Frame_Shift_Ins_p.A199fs			P16435	NCPR_HUMAN	P450 (cytochrome) oxidoreductase	297	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|lung(3)|ovary(1)	9					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	CAGGGAACCGAGCGCCACCTCA	0.599													23	82	---	---	---	---					
C9orf173	441476	broad.mit.edu	37	9	140145786	140145788	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:140145786_140145788delCAT	ENST00000388931.3	+	1	74_76	c.48_50delCAT	c.(46-51)tac>ta	p.YI16del	C9orf173_ENST00000412566.1_In_Frame_Del_p.YI16del	NM_001004353.3|NM_001256699.1|NM_001256700.1|NM_001256701.1	NP_001004353.2|NP_001243628.1|NP_001243629.1|NP_001243630.1	Q8N7X2	CI173_HUMAN	chromosome 9 open reading frame 173	16										kidney(1)|large_intestine(1)|lung(5)|pancreas(1)	8						CAAATTTTTACATCAATGGAGGC	0.567													138	40	---	---	---	---					
DIP2C	22982	broad.mit.edu	37	10	329222	329222	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:329222delA	ENST00000280886.6	-	35	4371	c.4284delT	c.(4282-4284)gafs	p.D1428fs		NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	1428						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTCCATTTGCATCTGTGAGCT	0.547													12	99	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65268382	65268383	+	RNA	DEL	GG	GG	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:65268382_65268383delGG	ENST00000534336.1	+	0	3150_3151					NR_002819.2																						GGGTGTTGTAGGTTTCTCTTTT	0.406													8	41	---	---	---	---					
CCND1	595	broad.mit.edu	37	11	69466013	69466021	+	In_Frame_Del	DEL	CTTGCACAC	CTTGCACAC	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:69466013_69466021delCTTGCACAC	ENST00000227507.2	+	5	1078_1086	c.851_859delCTTGCACAC	c.(850-861)gcc>g	p.ACTP284del		NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	284					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding	p.T286I(4)|p.P287S(2)		NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	gtggaCCTGGCTTGCACACCCACCGACGT	0.708			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			6	7	---	---	---	---					
KRT3	3850	broad.mit.edu	37	12	53189414	53189431	+	In_Frame_Del	DEL	CCAAAGCCACCAGCCCCT	CCAAAGCCACCAGCCCCT	-	rs142692092	by1000genomes	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:53189414_53189431delCCAAAGCCACCAGCCCCT	ENST00000417996.2	-	1	470_487	c.396_413delAGGGGCTGGTGGCTTTGG	c.(394-414)ggt>gg	p.GGAGGFG132del	KRT3_ENST00000309505.3_In_Frame_Del_p.GGAGGFG132del	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	132	Gly-rich.|Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						accaggaccaccaaagccaccagcccctccaaagccac	0.633													8	8	---	---	---	---					
RARG	5916	broad.mit.edu	37	12	53608326	53608338	+	Frame_Shift_Del	DEL	ATAGCTGTCAGGT	ATAGCTGTCAGGT	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:53608326_53608338delATAGCTGTCAGGT	ENST00000425354.2	-	6	1015_1027	c.528_540delACCTGACAGCTAT	c.(526-540)tcfs	p.SPDSY176fs	RARG_ENST00000543726.1_Frame_Shift_Del_p.SPDSY154fs|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000394426.1_Frame_Shift_Del_p.SPDSY176fs|RARG_ENST00000338561.5_Frame_Shift_Del_p.SPDSY165fs|RARG_ENST00000327550.3_Frame_Shift_Del_p.SPDSY104fs	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	176	Hinge.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGCTCAGCTCATAGCTGTCAGGTGACCCTTCTT	0.559													9	48	---	---	---	---					
RAP1B	5908	broad.mit.edu	37	12	69042549	69042549	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:69042549delA	ENST00000250559.9	+	2	276	c.45delA	c.(43-45)ggfs	p.G15fs	RAP1B_ENST00000540209.1_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000539091.1_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000463493.1_Intron|RAP1B_ENST00000543697.1_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000543393.1_Intron|RAP1B_ENST00000542145.1_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000450214.2_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000541216.1_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000341355.5_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000378985.3_Intron|RAP1B_ENST00000537460.1_Frame_Shift_Del_p.G15fs|RAP1B_ENST00000393436.5_Frame_Shift_Del_p.G15fs	NM_001010942.2|NM_001251921.1|NM_001251922.1|NM_015646.5	NP_001010942.1|NP_001238850.1|NP_001238851.1|NP_056461.1	P61224	RAP1B_HUMAN	RAP1B, member of RAS oncogene family	15					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(2)|urinary_tract(2)	12	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		GAGGCGTTGGAAAGTCTGCTT	0.363													13	33	---	---	---	---					
TESC	54997	broad.mit.edu	37	12	117479755	117479755	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:117479755delC	ENST00000335209.7	-	7	750	c.564delG	c.(562-564)ctfs	p.L188fs	TESC_ENST00000392545.4_Frame_Shift_Del_p.L241fs|TESC_ENST00000541210.1_Frame_Shift_Del_p.L161fs			Q96BS2	TESC_HUMAN	tescalcin	188					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		CACCCACCTTCAGGAAGTCCT	0.632													2	4	---	---	---	---					
OR4N5	390437	broad.mit.edu	37	14	20612342	20612343	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:20612342_20612343insT	ENST00000333629.1	+	1	448_449	c.448_449insT	c.(448-450)tggfs	p.W150fs		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GGTTCTGTGGCTTGGGGGCTTT	0.490													29	191	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102312241	102312241	+	RNA	DEL	A	A	-	rs59860046		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:102312241delA	ENST00000561463.1	+	0	13609																											AGTGGCCGGGAAATTTGCTGT	0.592													7	4	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	-	G	rs113730440		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:26684394_26684395insG	ENST00000540200.1	-	1	78		c.e1+1		POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2							mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													6	2	---	---	---	---					
PTPRT	11122	broad.mit.edu	37	20	41306573	41306573	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:41306573delG	ENST00000373198.3	-	7	1321	c.1086delC	c.(1084-1086)ctfs	p.L362fs	PTPRT_ENST00000373187.1_Frame_Shift_Del_p.L362fs|PTPRT_ENST00000373201.1_Frame_Shift_Del_p.L362fs|PTPRT_ENST00000356100.2_Frame_Shift_Del_p.L362fs|PTPRT_ENST00000373190.1_Frame_Shift_Del_p.L362fs|PTPRT_ENST00000373184.1_Frame_Shift_Del_p.L362fs|PTPRT_ENST00000373193.3_Frame_Shift_Del_p.L362fs	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	362	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTGGTCGTGTGAGGAGCACTC	0.567													24	106	---	---	---	---					
AC008103.5	0	broad.mit.edu	37	22	18842473	18842473	+	RNA	DEL	G	G	-	rs66618606		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18842473delG	ENST00000412938.1	+	0	2208																											AGCTGCTGGTGGGGAGGTCTT	0.647													3	5	---	---	---	---					
