Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FPGT	8790	broad.mit.edu	37	1	74670333	74670333	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:74670333C>T	ENST00000370898.2	+	4	639	c.602C>T	c.(601-603)aCc>aTc	p.T201I	FPGT_ENST00000524915.1_Intron|FPGT_ENST00000370894.4_Intron|FPGT_ENST00000534056.1_Intron|TNNI3K_ENST00000370893.1_Intron|FPGT-TNNI3K_ENST00000370899.3_Intron|FPGT-TNNI3K_ENST00000557284.1_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT-TNNI3K_ENST00000370895.1_Intron	NM_001199328.1|NM_003838.3	NP_001186257.1|NP_003829.2			fucose-1-phosphate guanylyltransferase											breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						ACGATAGGTACCACACATGGA	0.363000													5	70					0	0	1	0	0
KRTAP5-6	440023	broad.mit.edu	37	11	1718850	1718850	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:1718850C>A	ENST00000382160.1	+	1	426	c.375C>A	c.(373-375)tgC>tgA	p.C125*		NM_001012416.1	NP_001012416.1	Q6L8G9	KRA56_HUMAN	keratin associated protein 5-6	125						keratin filament				endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCATTTGCTGCCAGTGCAAAA	0.572000													18	104					9.16793e-09	1.05162e-08	1	1	0
DNAH7	56171	broad.mit.edu	37	2	196740432	196740432	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr2:196740432C>T	ENST00000312428.6	-	38	6353	c.6253G>A	c.(6253-6255)Gac>Aac	p.D2085N		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2085	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATCTGAATGTCCACTAGTTTA	0.393000													14	28					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1271277	1271277	+	Silent	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr2:1271277C>A	ENST00000308624.5	+	14	1347	c.1218C>A	c.(1216-1218)ggC>ggA	p.G406G	SNTG2_ENST00000407292.1_Silent_p.G279G	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	406	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		TGGAGCTTGGCAGCGAGCTGG	0.522000													3	19					0.00909568	0.00927403	1	1	0
PLA2G6	8398	broad.mit.edu	37	22	38531073	38531073	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr22:38531073G>C	ENST00000332509.3	-	6	999	c.816C>G	c.(814-816)atC>atG	p.I272M	PLA2G6_ENST00000335539.3_Missense_Mutation_p.I272M|PLA2G6_ENST00000402064.1_Missense_Mutation_p.I272M	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	272					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	TGTCCATGCTGATGATCATCT	0.612000													15	32					0	0	1	0	0
C10orf90	118611	broad.mit.edu	37	10	128193218	128193218	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr10:128193218G>A	ENST00000284694.7	-	3	671	c.551C>T	c.(550-552)gCc>gTc	p.A184V	C10orf90_ENST00000392694.1_Missense_Mutation_p.A137V|C10orf90_ENST00000356858.3_Missense_Mutation_p.A137V|C10orf90_ENST00000454341.1_Missense_Mutation_p.A184V|C10orf90_ENST00000368674.1_5'UTR|C10orf90_ENST00000544758.1_Missense_Mutation_p.A281V	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	184										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		ACCTGGATGGGCGCCATTGGC	0.647000											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	64					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185902905	185902905	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:185902905G>C	ENST00000271588.4	+	11	2006	c.1777G>C	c.(1777-1779)Gtt>Ctt	p.V593L	HMCN1_ENST00000367492.2_Missense_Mutation_p.V593L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	593	Ig-like C2-type 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCATTGTATGGTTTCTAGTGA	0.438000													12	122					0	0	1	0	0
AP5Z1	9907	broad.mit.edu	37	7	4820887	4820887	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr7:4820887C>T	ENST00000348624.4	+	2	217	c.123C>T	c.(121-123)acC>acT	p.T41T	AP5Z1_ENST00000401897.1_Silent_p.T41T	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	41					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										GGCCGGACACCCTCGACTCCC	0.602000													8	82					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10108062	10108062	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr19:10108062G>A	ENST00000264828.3	-	11	1333	c.1248C>T	c.(1246-1248)ggC>ggT	p.G416G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	416	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GACCAGGGTCGCCAGGGAATC	0.597000													3	17					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11319340	11319340	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:11319340C>A	ENST00000361445.4	-	2	203	c.127G>T	c.(127-129)Gag>Tag	p.E43*		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	43					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TGCTGGAGCTCCTTGGCGGCT	0.557000													20	95					7.45023e-12	8.87202e-12	1	1	0
TDRD1	56165	broad.mit.edu	37	10	115947746	115947746	+	Silent	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr10:115947746T>C	ENST00000251864.2	+	2	309	c.156T>C	c.(154-156)aaT>aaC	p.N52N	TDRD1_ENST00000369282.1_Silent_p.N52N|TDRD1_ENST00000369281.2_Silent_p.N52N|TDRD1_ENST00000369280.1_Silent_p.N52N|TDRD1_ENST00000422662.1_5'UTR	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	52					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		ACCACCCTAATTTCAGGCTGA	0.358000													10	82					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38162186	38162186	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr8:38162186T>C	ENST00000317025.8	-	14	3047	c.2530A>G	c.(2530-2532)Att>Gtt	p.I844V	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.I844V|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.I844V	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	844					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CAGATGAGAATGTAGGAGGAT	0.433000			T	NUP98	AML								15	92					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41949376	41949376	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:41949376C>T	ENST00000301831.4	-	12	1605	c.1143G>A	c.(1141-1143)atG>atA	p.M381I	ULK4_ENST00000420927.1_Missense_Mutation_p.M381I	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	381							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AACAGTGAGTCATATCCTCAC	0.413000													6	26					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667162	157667162	+	Silent	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:157667162C>A	ENST00000368184.3	-	6	903	c.612G>T	c.(610-612)ggG>ggT	p.G204G	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Silent_p.G204G	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	204	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TCATGGGACTCCCCTCTATGG	0.537000													5	64					0.0215528	0.0216918	1	1	0
TAF4	6874	broad.mit.edu	37	20	60581737	60581737	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr20:60581737C>T	ENST00000252996.3	-	7	2051	c.2052G>A	c.(2050-2052)ccG>ccA	p.P684P	TAF4_ENST00000488539.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	684	Poly-Pro.|TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GCGAGGTGGGCGGTGGCGGCT	0.692000													8	37					0	0	1	0	0
PPM1B	5495	broad.mit.edu	37	2	44457630	44457630	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr2:44457630G>C	ENST00000282412.4	+	6	1625	c.1213G>C	c.(1213-1215)Gga>Cga	p.G405R	PPM1B_ENST00000378540.4_Intron|PPM1B_ENST00000345249.4_Missense_Mutation_p.G118R|PPM1B_ENST00000409432.3_3'UTR|PPM1B_ENST00000378551.2_Intron	NM_002706.4	NP_002697.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	405					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TAATCATAGGGGAAACTACCG	0.468000													14	63					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121615009	121615009	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:121615009C>T	ENST00000328963.5	+	9	976	c.522C>T	c.(520-522)ttC>ttT	p.F174F	P2RX7_ENST00000377162.2_Silent_p.F255F|P2RX7_ENST00000535250.1_Silent_p.F254F|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000546057.1_Silent_p.F344F|P2RX7_ENST00000541446.1_Silent_p.F55F			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	344						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCTCCTACTTCGGTCTGGTAA	0.463000													10	33					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160289337	160289337	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr2:160289337C>T	ENST00000392783.2	-	9	2326	c.1831G>A	c.(1831-1833)Gaa>Aaa	p.E611K	BAZ2B_ENST00000392782.1_Missense_Mutation_p.E609K|BAZ2B_ENST00000355831.2_Missense_Mutation_p.E611K|BAZ2B_ENST00000343439.5_Missense_Mutation_p.E609K	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	611	Asp/Glu-rich (acidic).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						tcttcctcttcatcctcatTT	0.353000													6	61					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183822311	183822311	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr2:183822311T>C	ENST00000360982.2	-	20	2671	c.1913A>G	c.(1912-1914)cAt>cGt	p.H638R	NCKAP1_ENST00000361354.3_Missense_Mutation_p.H632R	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	632					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTTGGCACAATGCTTGGGTAG	0.378000													11	50					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96555301	96555301	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr13:96555301T>A	ENST00000376747.3	-	21	2379	c.2309A>T	c.(2308-2310)cAt>cTt	p.H770L		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	770					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						CAACCGACTATGAACACTTGT	0.313000													10	41					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69262996	69262996	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr14:69262996G>A	ENST00000408913.2	-	1	194	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C				Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	38					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GAGGCGCTGCGGGTGTACGTA	0.592000													22	59					0	0	1	0	0
ZBTB37	84614	broad.mit.edu	37	1	173839605	173839605	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:173839605A>G	ENST00000367704.1	+	3	641	c.242A>G	c.(241-243)gAa>gGa	p.E81G	ZBTB37_ENST00000427304.1_Missense_Mutation_p.E81G|ZBTB37_ENST00000367702.1_Missense_Mutation_p.E81G|ZBTB37_ENST00000367701.4_Missense_Mutation_p.E81G|ZBTB37_ENST00000432989.1_Missense_Mutation_p.E81G			Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37	81	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(4)	13						ACTGTTTTTGAACAGCTCCTT	0.473000													5	78					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189434	124189434	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:124189434G>A	ENST00000357438.2	-	1	750	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TAGAGAAAATGAAAGCATAAG	0.448000													5	89					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105417703	105417703	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr14:105417703A>C	ENST00000333244.5	-	7	4204	c.4085T>G	c.(4084-4086)aTg>aGg	p.M1362R	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1362						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGGAGGCTCATGTCGGCCTC	0.602000													29	172					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26895271	26895271	+	Silent	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr22:26895271G>T	ENST00000407690.1	-	9	1411	c.1128C>A	c.(1126-1128)gtC>gtA	p.V376V	TFIP11_ENST00000407431.1_Silent_p.V376V|TFIP11_ENST00000407148.1_Silent_p.V376V|TFIP11_ENST00000405938.1_Silent_p.V376V	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	376					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						CCATCTCCAGGACCTTGCTGA	0.617000													39	52					3.33393e-15	4.03173e-15	1	1	0
TGM2	7052	broad.mit.edu	37	20	36767845	36767845	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr20:36767845C>T	ENST00000361475.2	-	9	1484	c.1311G>A	c.(1309-1311)gaG>gaA	p.E437E	TGM2_ENST00000536701.1_Silent_p.E356E|TGM2_ENST00000536724.1_Silent_p.E377E	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	437					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	GGGTGATATCCTCCCGCTCGT	0.547000													4	45					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64557716	64557716	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:64557716T>A	ENST00000294066.2	-	29	2283	c.2192A>T	c.(2191-2193)gAg>gTg	p.E731V	MAP4K2_ENST00000377350.3_Missense_Mutation_p.E723V	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2	731	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						GGCCGTGGGCTCGCCCTGCAT	0.622000													6	42					0	0	1	0	0
ZFY	7544	broad.mit.edu	37	Y	2829478	2829478	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chrY:2829478A>T	ENST00000155093.3	+	3	746	c.425A>T	c.(424-426)cAt>cTt	p.H142L	ZFY_ENST00000449237.1_Missense_Mutation_p.H116L|ZFY_ENST00000431102.1_Intron|ZFY_ENST00000383052.1_Missense_Mutation_p.H142L	NM_003411.3	NP_003402.2	P08048	ZFY_HUMAN	zinc finger protein, Y-linked	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|kidney(3)|large_intestine(1)|lung(3)	8						GAATCCATGCATGTGTGTGAC	0.403000													94	53					0	0	1	0	0
RSBN1L	222194	broad.mit.edu	37	7	77379048	77379048	+	Silent	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr7:77379048C>G	ENST00000334955.7	+	3	1038	c.1011C>G	c.(1009-1011)ctC>ctG	p.L337L	RSBN1L_ENST00000445288.1_Silent_p.L67L	NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	337						nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGAATAACCTCAAAAGGTTGG	0.408000													6	51					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112681770	112681770	+	Silent	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:112681770G>T	ENST00000550722.1	-	30	4514	c.4119C>A	c.(4117-4119)gtC>gtA	p.V1373V	HECTD4_ENST00000430131.2_Silent_p.V1097V|HECTD4_ENST00000377560.5_Silent_p.V1347V	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CAGGCTGCCTGACAGCGTGAG	0.388000													7	45					0.00198382	0.00206317	1	1	0
NOD1	10392	broad.mit.edu	37	7	30491286	30491286	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr7:30491286C>G	ENST00000222823.4	-	6	2272	c.1747G>C	c.(1747-1749)Gat>Cat	p.D583H		NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	583					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						TGGAAGTGATCCTTGTTCTTG	0.617000													8	93					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75501072	75501072	+	Missense_Mutation	SNP	C	C	T	rs79122600		TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr15:75501072C>T	ENST00000360639.2	+	2	3003	c.2683C>T	c.(2683-2685)Cgc>Tgc	p.R895C	C15orf39_ENST00000567617.1_Missense_Mutation_p.R895C|C15orf39_ENST00000394987.4_Missense_Mutation_p.R895C			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	895										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						CTGCACCTCACGCATGCTGAA	0.672000													3	14					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906828	13906828	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:13906828G>A	ENST00000279593.3	-	3	642	c.433C>T	c.(433-435)Cag>Tag	p.Q145*		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	145					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGGCCAAACTGGAAGAACATG	0.393000													6	31					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21355450	21355450	+	Silent	SNP	A	A	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:21355450A>T	ENST00000256958.2	+	10	1257	c.1161A>T	c.(1159-1161)gcA>gcT	p.A387A		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	387					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CTATTTTTGCAAGTGGAATGT	0.299000													6	20					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579699	7579699	+	Splice_Site	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:7579699C>A	ENST00000420246.2	-	3	229		c.e3+1		TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.0?(8)|p.S33fs*10(1)|p.P13fs*18(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTGTCCTTACCAGAACGTTG	0.597000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	35					4.3838e-07	4.88481e-07	1	1	0
FAM214A	56204	broad.mit.edu	37	15	52902410	52902410	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr15:52902410C>T	ENST00000261844.7	-	6	853	c.701G>A	c.(700-702)gGc>gAc	p.G234D	FAM214A_ENST00000546305.2_Missense_Mutation_p.G241D	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	234																	CTCATAAAGGCCAATATTAGT	0.388000													10	53					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161618	90161618	+	RNA	SNP	C	C	T	rs13338202	by1000genomes	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr16:90161618C>T	ENST00000567960.1	+	0	354				TUBB8P7_ENST00000564451.1_RNA														p.D118D(2)									CAGTGATGGACGTTGTCAGAA	0.607000													4	36					0	0	1	0	0
PSPC1	55269	broad.mit.edu	37	13	20277461	20277461	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr13:20277461C>A	ENST00000338910.4	-	9	1585	c.1426G>T	c.(1426-1428)Ggt>Tgt	p.G476C		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	476	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		ATAGGTGAACCCATCTGAGAT	0.463000													7	31					0.000442599	0.000469697	1	1	0
BMP3	651	broad.mit.edu	37	4	81967329	81967329	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr4:81967329C>A	ENST00000282701.2	+	2	1074	c.754C>A	c.(754-756)Cca>Aca	p.P252T		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	252					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity	p.P252S(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						CATTTCTGAGCCAGAAAGTGT	0.483000													22	73					1.55795e-14	1.86953e-14	1	1	0
PITX1	5307	broad.mit.edu	37	5	134364688	134364688	+	Silent	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr5:134364688G>T	ENST00000265340.7	-	3	1142	c.726C>A	c.(724-726)ctC>ctA	p.L242L	PITX1_ENST00000506438.1_Silent_p.L242L	NM_002653.4	NP_002644.4	P78337	PITX1_HUMAN	paired-like homeodomain 1	242	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding			central_nervous_system(1)|cervix(3)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		TGATGTTGTTGAGGCCCGAGT	0.662000													7	39					8.12818e-05	8.80553e-05	1	1	0
ZFYVE9	9372	broad.mit.edu	37	1	52705057	52705057	+	Silent	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:52705057C>A	ENST00000287727.3	+	4	2140	c.1968C>A	c.(1966-1968)atC>atA	p.I656I	ZFYVE9_ENST00000371591.1_Silent_p.I656I|ZFYVE9_ENST00000361625.1_Silent_p.I656I|ZFYVE9_ENST00000357206.2_Silent_p.I656I	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	656					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AGGCTGAGATCTCCACTAGAC	0.443000													29	87					1.16021e-09	1.34069e-09	1	1	0
EPB41L4A	64097	broad.mit.edu	37	5	111576462	111576462	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr5:111576462A>T	ENST00000261486.5	-	10	1117	c.841T>A	c.(841-843)Tgc>Agc	p.C281S	RP11-526F3.1_ENST00000504004.1_RNA	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	281	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		AGGTGCTTGCAAGCAGTTTTA	0.343000													6	28					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123657346	123657346	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chrX:123657346C>G	ENST00000422452.2	-	17	2964	c.2901G>C	c.(2899-2901)caG>caC	p.Q967H	TENM1_ENST00000371130.3_Missense_Mutation_p.Q967H	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ATACAACTCTCTGCATGGTGA	0.483000													12	39					0	0	1	0	0
CYP2D6	1565	broad.mit.edu	37	22	42523915	42523915	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr22:42523915G>A	ENST00000360608.5	-	6	1028	c.914C>T	c.(913-915)gCc>gTc	p.A305V	NDUFA6-AS1_ENST00000439129.1_RNA|NDUFA6-AS1_ENST00000416037.1_RNA|CYP2D6_ENST00000389970.3_Missense_Mutation_p.A305V|CYP2D6_ENST00000359033.4_Missense_Mutation_p.A254V	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	305							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CACCATCCCGGCAGAGAACAG	0.607000													8	73					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108716281	108716281	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr10:108716281A>T	ENST00000263054.6	-	2	623	c.616T>A	c.(616-618)Tcg>Acg	p.S206T	SORCS1_ENST00000344440.6_Missense_Mutation_p.S206T	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	206						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTCCAAAGCGAGCTCTCTGTG	0.423000													8	27					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77334208	77334208	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr16:77334208A>G	ENST00000282849.5	-	17	3044	c.2626T>C	c.(2626-2628)Tat>Cat	p.Y876H		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	876	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CTCCAGGTATAGGCAGGTCTT	0.468000													4	51					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37936551	37936551	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr7:37936551G>C	ENST00000199447.4	+	17	1996	c.1624G>C	c.(1624-1626)Gaa>Caa	p.E542Q	NME8_ENST00000440017.1_Missense_Mutation_p.E542Q|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	542	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										AACAGACCCAGAAGAAGCAAA	0.453000													6	109					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191029	152191029	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:152191029G>A	ENST00000368801.2	-	3	3151	c.3076C>T	c.(3076-3078)Cca>Tca	p.P1026S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1026					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTATATGGGCCATAGCTG	0.602000													109	177					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	853491	853491	+	Silent	SNP	T	T	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr4:853491T>A	ENST00000314167.4	-	24	3296	c.3186A>T	c.(3184-3186)ggA>ggT	p.G1062G	GAK_ENST00000511163.1_Silent_p.G983G|GAK_ENST00000509566.1_5'UTR	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	1062					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		CCGGCTGACCTCCAGGAGAGA	0.617000													7	52					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99772531	99772531	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:99772531A>C	ENST00000370185.3	+	7	2754	c.2257A>C	c.(2257-2259)Aaa>Caa	p.K753Q	LPPR4_ENST00000370184.1_Missense_Mutation_p.K595Q|LPPR4_ENST00000457765.1_Missense_Mutation_p.K695Q	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		753							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TATCTTCTACAAAGGAACCTC	0.458000													12	66					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62122834	62122834	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:62122834G>A	ENST00000433197.2	-	20	2633	c.2538C>T	c.(2536-2538)agC>agT	p.S846S		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	846	KEN.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CTATTCTGTCGCTCACGTCCT	0.542000													11	47					0	0	1	0	0
KCNJ16	3773	broad.mit.edu	37	17	68129080	68129080	+	Silent	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:68129080T>C	ENST00000585558.1	+	4	1345	c.957T>C	c.(955-957)taT>taC	p.Y319Y	KCNJ16_ENST00000589377.1_Silent_p.Y284Y|KCNJ16_ENST00000392671.1_Silent_p.Y284Y|KCNJ16_ENST00000392670.1_Silent_p.Y284Y|KCNJ16_ENST00000283936.1_Silent_p.Y284Y|KCNJ16_ENST00000586462.1_Silent_p.Y323Y			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	284					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					CATTTATCTATACTGGTGATT	0.418000													48	66					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7804770	7804770	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr5:7804770G>T	ENST00000338316.4	+	22	2937	c.2848G>T	c.(2848-2850)Ggt>Tgt	p.G950C	ADCY2_ENST00000537121.1_Missense_Mutation_p.G770C	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	950					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGCAGCAACAGGTCTGAGCGC	0.527000													4	32					0.000602214	0.000634767	1	1	0
PCYOX1L	78991	broad.mit.edu	37	5	148743614	148743614	+	Missense_Mutation	SNP	G	G	A	rs35456382	byFrequency	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr5:148743614G>A	ENST00000514349.1	+	2	620	c.41G>A	c.(40-42)cGc>cAc	p.R14H	PCYOX1L_ENST00000274569.4_Missense_Mutation_p.R104H			Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	104					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCACCGGCGCGAGGTGGTG	0.602000													10	43					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132194150	132194150	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr6:132194150C>A	ENST00000360971.2	+	15	1545	c.1525C>A	c.(1525-1527)Ccc>Acc	p.P509T		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	509	Phosphodiesterase.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TAGAATTGAGCCCTTGACATT	0.433000													18	162					1.99824e-07	2.24262e-07	1	1	0
SMCHD1	23347	broad.mit.edu	37	18	2760723	2760723	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr18:2760723C>G	ENST00000320876.6	+	35	4758	c.4420C>G	c.(4420-4422)Ctc>Gtc	p.L1474V	SMCHD1_ENST00000261598.8_Missense_Mutation_p.L1474V|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1474					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						AACAAATATTCTCAACAGTGA	0.294000													5	33					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52901118	52901118	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:52901118G>A	ENST00000371544.3	-	27	4441	c.4179C>T	c.(4177-4179)aaC>aaT	p.N1393N	ZCCHC11_ENST00000257177.4_Silent_p.N1394N	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1393					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						CATTTACAAGGTTGCGGACCA	0.438000													5	35					0	0	1	0	0
ADRA1A	148	broad.mit.edu	37	8	26627799	26627799	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr8:26627799C>T	ENST00000380573.3	-	3	2291	c.1268G>A	c.(1267-1269)cGg>cAg	p.R423Q	ADRA1A_ENST00000380586.1_Splice_Site_p.R423_splice|ADRA1A_ENST00000380587.1_Intron|ADRA1A_ENST00000519229.1_Splice_Site_p.R423_splice|ADRA1A_ENST00000380582.3_Splice_Site_p.R423_splice|ADRA1A_ENST00000354550.4_Splice_Site_p.R423_splice|ADRA1A_ENST00000380581.2_Intron|ADRA1A_ENST00000276393.4_Missense_Mutation_p.R423Q			P35348	ADA1A_HUMAN	adrenoceptor alpha 1A	423					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|skin(1)	36		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	ACTTCTCACCCGGGCTGTGGT	0.507000													39	54					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248309152	248309152	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:248309152C>G	ENST00000366476.1	+	1	703	c.703C>G	c.(703-705)Cgc>Ggc	p.R235G		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R235C(1)		NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			AGAGGGTCGTCGCAAAGCTTT	0.473000													88	171					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927520	92927520	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chrX:92927520C>A	ENST00000373079.3	-	1	1047	c.784G>T	c.(784-786)Gat>Tat	p.D262Y	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	262					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TGTTCTTTATCATCTGCCTTT	0.443000													9	50					2.17888e-05	2.3937e-05	1	1	0
CPEB2	132864	broad.mit.edu	37	4	15063828	15063828	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr4:15063828A>G	ENST00000538197.1	+	11	2821	c.2821A>G	c.(2821-2823)Att>Gtt	p.I941V	CPEB2_ENST00000345451.3_Missense_Mutation_p.I466V|RP11-665G4.1_ENST00000502344.1_RNA|CPEB2_ENST00000259997.5_Missense_Mutation_p.I504V|CPEB2_ENST00000541112.1_Missense_Mutation_p.I933V|RP11-665G4.1_ENST00000513384.1_RNA|CPEB2_ENST00000382401.3_Missense_Mutation_p.I469V|CPEB2_ENST00000507071.1_Missense_Mutation_p.I496V|CPEB2_ENST00000382395.3_Missense_Mutation_p.I474V|CPEB2_ENST00000442003.2_Missense_Mutation_p.I914V	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	496					regulation of translation	cytoplasm	nucleotide binding|RNA binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						GCAGAGCTATATTGCTGCCAT	0.418000													17	133					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400822	195400822	+	RNA	SNP	G	G	A	rs56170658	by1000genomes	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:195400822G>A	ENST00000445430.1	+	0	1418																											GTCTGGTCAGGCATGTGCCCT	0.572000													4	38					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119754819	119754819	+	Silent	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr4:119754819C>G	ENST00000379735.5	-	2	304	c.33G>C	c.(31-33)ccG>ccC	p.P11P	SEC24D_ENST00000280551.6_Silent_p.P11P|SEC24D_ENST00000419654.2_5'UTR	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	11	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						GCTGAGAATACGGAGGTGTAG	0.433000													8	59					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24516638	24516638	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr2:24516638G>C	ENST00000355123.4	-	15	2085	c.1642C>G	c.(1642-1644)Cag>Gag	p.Q548E	ITSN2_ENST00000406921.3_Missense_Mutation_p.Q548E|ITSN2_ENST00000361999.3_Missense_Mutation_p.Q548E	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	548					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCTTATTCTGATATTCCTTA	0.284000													5	33					0	0	1	0	0
UAP1	6675	broad.mit.edu	37	1	162569111	162569111	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:162569111C>T	ENST00000271469.3	+	11	1829	c.1527C>T	c.(1525-1527)atC>atT	p.I509I	UAP1_ENST00000367925.1_Silent_p.I509I|UAP1_ENST00000367924.1_Silent_p.I508I|UAP1_ENST00000367926.4_Silent_p.I492I|UAP1_ENST00000486089.1_3'UTR			Q16222	UAP1_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1	509					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			breast(2)|cervix(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)|skin(2)|stomach(1)	22	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CTCTAATCATCGATGAGAATG	0.343000													3	34					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74418524	74418524	+	Splice_Site	SNP	A	A	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:74418524A>G	ENST00000263665.6	-	7	789	c.761_splice	c.e7-1	p.N254_splice		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	254	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GAGGTATGGGACTAAGAAGAA	0.378000													5	24					0	0	1	0	0
PARP6	56965	broad.mit.edu	37	15	72552938	72552938	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr15:72552938T>C	ENST00000569795.1	-	10	1324	c.637A>G	c.(637-639)Atc>Gtc	p.I213V	PARP6_ENST00000260376.7_Missense_Mutation_p.I213V|PARP6_ENST00000413097.2_5'UTR|PARP6_ENST00000287196.9_Missense_Mutation_p.I213V			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	213							NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						GTACAGGAGATGGAACGGTTC	0.582000													135	231					0	0	1	0	0
OTUD7A	161725	broad.mit.edu	37	15	31947302	31947302	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr15:31947302C>A	ENST00000382902.1	-	1	240	c.148G>T	c.(148-150)Gaa>Taa	p.E50*	OTUD7A_ENST00000307050.4_Nonsense_Mutation_p.E50*			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	50						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GGCTTACCTTCCAGCAGGTCT	0.507000													12	9					0.000219431	0.000236078	1	1	0
ZIC3	7547	broad.mit.edu	37	X	136649292	136649292	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chrX:136649292C>A	ENST00000287538.5	+	1	992	c.442C>A	c.(442-444)Cat>Aat	p.H148N	ZIC3_ENST00000370606.3_Missense_Mutation_p.H148N	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	148					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					GAGCAGCCTGCATGCTCCAGC	0.701000													4	12					0.00909568	0.00927403	1	1	0
C11orf70	85016	broad.mit.edu	37	11	101951964	101951964	+	Silent	SNP	A	A	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:101951964A>G	ENST00000434758.2	+	6	655	c.627A>G	c.(625-627)caA>caG	p.Q209Q	C11orf70_ENST00000526781.1_Silent_p.Q209Q	NM_032930.2	NP_116319.2	Q9BRQ4	CK070_HUMAN	chromosome 11 open reading frame 70	209										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		AGAATCCTCAAACCAAGAAAA	0.284000													8	26					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25231988	25231988	+	RNA	SNP	C	C	G	rs59131251	by1000genomes	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr15:25231988C>G	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						AGAGATGACACgtgtatgtgc	0.478000													3	19					0	0	1	0	0
TCTN3	26123	broad.mit.edu	37	10	97447374	97447374	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr10:97447374G>C	ENST00000265993.8	-	4	845	c.602C>G	c.(601-603)aCt>aGt	p.T201S	TCTN3_ENST00000371217.4_Missense_Mutation_p.T219S|TCTN3_ENST00000430368.1_Intron|TCTN3_ENST00000371209.5_Missense_Mutation_p.T201S	NM_015631.5	NP_056446.4	Q6NUS6	TECT3_HUMAN	tectonic family member 3	201					apoptosis	integral to membrane				breast(3)|endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		TGGTGATTGAGTTTGGAATGT	0.443000													13	28					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49580524	49580524	+	Silent	SNP	G	G	A	rs139102191	byFrequency	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:49580524G>A	ENST00000301071.7	-	2	440	c.96C>T	c.(94-96)ccC>ccT	p.P32P	TUBA1A_ENST00000550767.1_5'UTR|TUBA1A_ENST00000295766.5_Silent_p.P32P|TUBA1A_ENST00000546918.1_Silent_p.P32P	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	32					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						TCTGGCCATCGGGCTGGATGC	0.602000													12	60					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47860937	47860937	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr21:47860937T>A	ENST00000359568.5	+	43	9670	c.9563T>A	c.(9562-9564)aTc>aAc	p.I3188N	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	3188	Interaction with NEK2.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GAACGGAAAATCACATCTCGT	0.473000													20	38					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153588703	153588703	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chrX:153588703C>T	ENST00000422373.1	-	22	3708	c.3460G>A	c.(3460-3462)Gtg>Atg	p.V1154M	FLNA_ENST00000344736.4_Missense_Mutation_p.V1154M|FLNA_ENST00000369850.3_Missense_Mutation_p.V1154M|FLNA_ENST00000360319.4_Missense_Mutation_p.V1154M	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1154					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGGGAACCACGTGGGCCTTG	0.622000											OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	36					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158299853	158299853	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:158299853C>T	ENST00000368168.3	-	3	503	c.396G>A	c.(394-396)ctG>ctA	p.L132L		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	132					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					GAGCTCCCCTCAGGAAGCTTA	0.488000													35	163					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53607444	53607444	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:53607444G>A	ENST00000425354.2	-	8	1341	c.854C>T	c.(853-855)aCc>aTc	p.T285I	RARG_ENST00000543762.1_5'UTR|RARG_ENST00000394426.1_Missense_Mutation_p.T285I|RARG_ENST00000338561.5_Missense_Mutation_p.T274I|RARG_ENST00000327550.3_Missense_Mutation_p.T213I|RARG_ENST00000543726.1_Missense_Mutation_p.T263I	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	285	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GAAGGTCATGGTGTCCTGCTC	0.602000											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	54					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53639489	53639489	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr16:53639489C>T	ENST00000262135.4	-	24	3592	c.3499G>A	c.(3499-3501)Gag>Aag	p.E1167K	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.E1247K|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.E1201K|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.E1213K	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	1247					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				AGGTCCTGCTCGTCCTCTGGA	0.527000													7	48					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183891453	183891453	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:183891453T>C	ENST00000304685.3	+	18	2668	c.2207T>C	c.(2206-2208)gTc>gCc	p.V736A	RGL1_ENST00000360851.3_Missense_Mutation_p.V701A|RGL1_ENST00000539189.1_Missense_Mutation_p.V672A|RGL1_ENST00000367531.1_Missense_Mutation_p.V736A|RGL1_ENST00000536277.1_Missense_Mutation_p.V699A	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	701					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						CTGGTGCAGGTCATCTCGGAG	0.582000											OREG0014047	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	27					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107005323	107005323	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr10:107005323C>A	ENST00000369701.3	+	21	3119	c.2892C>A	c.(2890-2892)agC>agA	p.S964R	SORCS3_ENST00000369699.4_3'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	964						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TGGACAGCAGCATTTCCTTCA	0.453000													16	115					3.45872e-05	3.77315e-05	1	1	0
TRBC2	28638	broad.mit.edu	37	7	142499762	142499762	+	RNA	SNP	A	A	G	rs706	by1000genomes	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr7:142499762A>G	ENST00000466254.1	+	0	405																											GTGCACAGGTACCTACATGCT	0.542000													4	135					0	0	1	0	0
RARB	5915	broad.mit.edu	37	3	25622137	25622137	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:25622137A>T	ENST00000330688.4	+	5	1131	c.710A>T	c.(709-711)aAa>aTa	p.K237I	RARB_ENST00000462272.1_3'UTR|RARB_ENST00000437042.2_Missense_Mutation_p.K125I|RARB_ENST00000404969.1_Missense_Mutation_p.K244I|RARB_ENST00000458646.1_Missense_Mutation_p.K125I	NM_000965.3	NP_000956.2	P10826	RARB_HUMAN	retinoic acid receptor, beta	244	Ligand-binding.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	GAGTTTGCTAAACGTCTGCCT	0.517000													6	58					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64507257	64507257	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:64507257T>A	ENST00000377494.1	-	6	1469	c.547A>T	c.(547-549)Act>Tct	p.T183S	RASGRP2_ENST00000377497.3_Missense_Mutation_p.T183S|RASGRP2_ENST00000394432.3_Missense_Mutation_p.T183S|RASGRP2_ENST00000354024.3_Missense_Mutation_p.T183S			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	183	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAGCCATGAGTCACGAAACTG	0.582000													21	47					0	0	1	0	0
CD200R1L	344807	broad.mit.edu	37	3	112545855	112545855	+	Missense_Mutation	SNP	C	C	T	rs142953807	by1000genomes	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:112545855C>T	ENST00000488794.1	-	6	1190	c.601G>A	c.(601-603)Gta>Ata	p.V201I	CD200R1L_ENST00000398214.1_Missense_Mutation_p.V222I|CD200R1L_ENST00000448932.1_Missense_Mutation_p.V201I			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	222	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						TTCAACTTTACGGACAGACTC	0.448000													9	77					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117222548	117222548	+	Silent	SNP	C	C	T	rs149281923		TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:117222548C>T	ENST00000278935.3	+	5	384	c.237C>T	c.(235-237)aaC>aaT	p.N79N		NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	79	Interaction with ATRIP.|WW.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		ACTTCGCCAACGGGCAGTCTA	0.478000													10	53					0	0	1	0	0
C12orf4	57102	broad.mit.edu	37	12	4609473	4609473	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:4609473G>C	ENST00000261250.3	-	11	1358	c.1271C>G	c.(1270-1272)tCa>tGa	p.S424*	C12orf4_ENST00000545746.1_Nonsense_Mutation_p.S424*	NM_020374.2	NP_065107.1	Q9NQ89	CL004_HUMAN	chromosome 12 open reading frame 4	424										NS(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		ATGGATTTCTGAGAGATTAGA	0.393000													17	44					0	0	1	0	0
IGLJ2	28832	broad.mit.edu	37	22	23241811	23241811	+	RNA	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr22:23241811G>A	ENST00000390322.2	+	0	151																											GGTATTCGGCGGAGGGACCAA	0.562000													36	55					0	0	1	0	0
OR1D2	4991	broad.mit.edu	37	17	2996173	2996173	+	Missense_Mutation	SNP	C	C	G	rs140099014	byFrequency	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:2996173C>G	ENST00000331459.1	-	1	117	c.118G>C	c.(118-120)Gtg>Ctg	p.V40L		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	40					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						ACATTTCCCACCACCGTGACC	0.547000													6	124					0	0	1	0	0
BROX	148362	broad.mit.edu	37	1	222897441	222897441	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:222897441G>C	ENST00000340934.5	+	6	815	c.409G>C	c.(409-411)Gaa>Caa	p.E137Q	BROX_ENST00000539697.1_Missense_Mutation_p.E105Q|BROX_ENST00000537020.1_Missense_Mutation_p.E137Q	NM_144695.2	NP_653296.2	Q5VW32	BROX_HUMAN	BRO1 domain and CAAX motif containing	137	BRO1.					membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|stomach(1)	14						AAGTATAACAGAAGATGAAGC	0.303000													6	24					0	0	1	0	0
PLS3	5358	broad.mit.edu	37	X	114874792	114874792	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chrX:114874792G>A	ENST00000420625.2	+	9	1098	c.964G>A	c.(964-966)Gat>Aat	p.D322N	PLS3_ENST00000537301.1_Missense_Mutation_p.D309N|PLS3_ENST00000355899.3_Missense_Mutation_p.D322N|PLS3_ENST00000289290.3_Missense_Mutation_p.D286N|PLS3_ENST00000543070.1_5'UTR|PLS3_ENST00000539310.1_Missense_Mutation_p.D277N	NM_001136025.3|NM_001172335.1	NP_001129497.1|NP_001165806.1	P13797	PLST_HUMAN	plastin 3	322	Actin-binding 1.|CH 2.					cytoplasm	actin binding|calcium ion binding			NS(2)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)	26						ACCACGGATAGATATTAACAT	0.313000													11	26					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17599307	17599307	+	Silent	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr20:17599307T>C	ENST00000377813.1	-	20	3996	c.3693A>G	c.(3691-3693)ctA>ctG	p.L1231L	RRBP1_ENST00000468428.1_5'UTR|RRBP1_ENST00000360807.4_Silent_p.L798L|RRBP1_ENST00000377807.2_Silent_p.L798L|RRBP1_ENST00000455029.2_Silent_p.L572L|RRBP1_ENST00000246043.4_Silent_p.L1231L			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1231					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						ATTGAGATTCTAGGAGAAGTT	0.542000													6	46					0	0	1	0	0
DNAJB11	51726	broad.mit.edu	37	3	186289893	186289893	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:186289893C>G	ENST00000439351.1	+	3	1007	c.78C>G	c.(76-78)ttC>ttG	p.F26L	DNAJB11_ENST00000265028.3_Missense_Mutation_p.F26L			Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	26	J.				protein folding	endoplasmic reticulum lumen	heat shock protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|urinary_tract(2)	15	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		GACGAGATTTCTATAAGATCT	0.393000													4	58					0	0	1	0	0
PMF1	11243	broad.mit.edu	37	1	156209338	156209338	+	Splice_Site	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:156209338G>T	ENST00000368277.3	+	5	573		c.e5-1		PMF1-BGLAP_ENST00000320139.5_Intron|PMF1_ENST00000368279.3_Splice_Site|PMF1-BGLAP_ENST00000490491.1_Intron|PMF1_ENST00000368273.4_Splice_Site|PMF1_ENST00000567140.1_Intron|PMF1_ENST00000565805.1_Intron|PMF1-BGLAP_ENST00000368276.4_Intron	NM_007221.3	NP_009152.2			polyamine-modulated factor 1											kidney(1)|large_intestine(2)|lung(3)	6	Hepatocellular(266;0.158)					ATTGATTTCAGGCTCTACACA	0.567000													23	89					1.42536e-11	1.67185e-11	1	1	0
DUSP4	1846	broad.mit.edu	37	8	29207652	29207652	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr8:29207652C>T	ENST00000240100.2	-	1	533	c.144G>A	c.(142-144)ctG>ctA	p.L48L		NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	48	Rhodanese.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		GTCTGCAGTCCAGCAGCAGGC	0.687000													8	13					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205156746	205156746	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:205156746G>A	ENST00000367162.3	-	2	484	c.454C>T	c.(454-456)Cgc>Tgc	p.R152C	DSTYK_ENST00000367161.3_Missense_Mutation_p.R152C|DSTYK_ENST00000367160.4_Missense_Mutation_p.R152C	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	152						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						AAGCGGAGGCGCCGAAGCTTA	0.587000													5	45					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43531711	43531711	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr21:43531711G>A	ENST00000400427.1	+	11	2559	c.2163G>A	c.(2161-2163)cgG>cgA	p.R721R	UMODL1_ENST00000400424.1_Silent_p.R593R|UMODL1_ENST00000408910.2_Silent_p.R665R|UMODL1_ENST00000408989.2_Silent_p.R793R	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	718	Fibronectin type-III 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						GTTCCACCCGGGAAACACTTC	0.602000													18	24					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18255941	18255941	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr19:18255941G>A	ENST00000262811.5	+	23	2854	c.2854G>A	c.(2854-2856)Gtt>Att	p.V952I	AC007192.6_ENST00000600364.1_RNA	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	952	PDZ.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						GCCCCCCATCGTTATCCACAG	0.652000													21	108					0	0	1	0	0
WDR59	79726	broad.mit.edu	37	16	74949804	74949804	+	Silent	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr16:74949804G>C	ENST00000262144.6	-	13	1318	c.1188C>G	c.(1186-1188)tcC>tcG	p.S396S		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	396	RWD.									breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CATTGATCAGGGAGAATTCCT	0.468000													7	56					0	0	1	0	0
SORT1	6272	broad.mit.edu	37	1	109870185	109870185	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:109870185C>T	ENST00000256637.6	-	12	1468	c.1410G>A	c.(1408-1410)caG>caA	p.Q470Q	SORT1_ENST00000538502.1_Silent_p.Q333Q	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	470					endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		CATTCAGTTTCTGGGAGATGC	0.438000													9	34					0	0	1	0	0
SLC2A4	6517	broad.mit.edu	37	17	7189281	7189281	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:7189281C>A	ENST00000424875.2	+	10	1647	c.1350C>A	c.(1348-1350)caC>caA	p.H450Q	SLC2A4_ENST00000571308.1_Missense_Mutation_p.H460Q|SLC2A4_ENST00000317370.8_Intron			P14672	GTR4_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 4	0					carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding			breast(1)|endometrium(3)|large_intestine(7)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17						GGGCATCACACAGCTAGCCCA	0.592000													4	11					0.00024832	0.000265328	1	1	0
WHSC1L1	54904	broad.mit.edu	37	8	38172932	38172932	+	Splice_Site	SNP	A	A	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr8:38172932A>T	ENST00000317025.8	-	11	2633		c.e11+1		WHSC1L1_ENST00000527502.1_Splice_Site|WHSC1L1_ENST00000433384.2_Splice_Site	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1						cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TTACCTGCCTACCTGACATAC	0.403000			T	NUP98	AML								19	141					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48703424	48703424	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:48703424C>G	ENST00000236495.5	+	12	1491	c.1441C>G	c.(1441-1443)Ctc>Gtc	p.L481V	SLC5A9_ENST00000533824.1_Missense_Mutation_p.L477V|SLC5A9_ENST00000438567.2_Missense_Mutation_p.L456V	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	456						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						CAGTGGGCAGCTCTTCGACTA	0.572000													7	64					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20666448	20666448	+	RNA	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr15:20666448C>T	ENST00000428453.1	-	0	870																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TTCTTACTGGCACATTCAATC	0.433000													3	22					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180377524	180377524	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:180377524C>A	ENST00000273654.4	-	11	1421	c.802G>T	c.(802-804)Gaa>Taa	p.E268*	CCDC39_ENST00000442201.2_Nonsense_Mutation_p.E184*			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	184					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton		p.E268*(1)		NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TGATTACATTCCAAAGTTAGT	0.289000													3	32					0.004672	0.0048267	1	1	0
CYP4B1	1580	broad.mit.edu	37	1	47279207	47279207	+	Silent	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:47279207T>C	ENST00000271153.4	+	5	585	c.549T>C	c.(547-549)gaT>gaC	p.D183D	CYP4B1_ENST00000452782.2_Silent_p.D20D|CYP4B1_ENST00000371919.4_Silent_p.D168D|CYP4B1_ENST00000371923.4_Silent_p.D183D			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	183					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TCTTCTGCGATGTGGGTCACA	0.587000													6	57					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79461549	79461549	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr9:79461549C>T	ENST00000376718.3	-	4	513	c.390G>A	c.(388-390)ccG>ccA	p.P130P	PRUNE2_ENST00000428286.1_5'UTR|PRUNE2_ENST00000376713.3_Silent_p.P130P	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	130					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCTGCTCAACCGGATTAATGA	0.458000													6	27					0	0	1	0	0
ZBTB25	7597	broad.mit.edu	37	14	64954651	64954651	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr14:64954651G>A	ENST00000394715.1	-	6	999	c.298C>T	c.(298-300)Cga>Tga	p.R100*	ZBTB25_ENST00000555424.1_Intron|ZBTB25_ENST00000555220.1_Intron|ZBTB25_ENST00000261683.2_Nonsense_Mutation_p.R100*			P24278	ZBT25_HUMAN	zinc finger and BTB domain containing 25	100	BTB.					cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(2)|skin(2)	10				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TGAAGAAATCGAATCCCTTCC	0.423000													10	77					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33461017	33461017	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr5:33461017G>C	ENST00000265112.3	+	12	1572	c.1261G>C	c.(1261-1263)Gat>Cat	p.D421H	TARS_ENST00000541634.1_Missense_Mutation_p.D317H|TARS_ENST00000502553.1_Missense_Mutation_p.D421H|TARS_ENST00000455217.2_Missense_Mutation_p.D454H|TARS_ENST00000414361.2_Missense_Mutation_p.D300H	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	421					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	CCTTATGTTTGATCATCGGCC	0.453000													5	49					0	0	1	0	0
MFSD1	64747	broad.mit.edu	37	3	158531858	158531858	+	Splice_Site	SNP	T	T	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:158531858T>C	ENST00000415822.2	+	7	940		c.e7+2		MFSD1_ENST00000264266.8_Splice_Site|MFSD1_ENST00000392813.4_Splice_Site	NM_022736.2	NP_073573.2	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing 1						transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	26			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTATGATTGGTGAGTGAATCC	0.448000													6	38					0	0	1	0	0
ZFYVE21	79038	broad.mit.edu	37	14	104199002	104199002	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr14:104199002C>T	ENST00000216602.6	+	7	738	c.626C>T	c.(625-627)cCg>cTg	p.P209L	ZFYVE21_ENST00000311141.2_Missense_Mutation_p.P191L	NM_001198953.1	NP_001185882.1	Q9BQ24	ZFY21_HUMAN	zinc finger, FYVE domain containing 21	191						cytoplasmic membrane-bounded vesicle|focal adhesion	metal ion binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(2)	8		Melanoma(154;0.226)		Epithelial(152;0.245)		TATACAGTGCCGGGGACGGAG	0.642000													7	63					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31709908	31709908	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr18:31709908G>A	ENST00000261592.5	-	2	638	c.341C>T	c.(340-342)tCg>tTg	p.S114L	NOL4_ENST00000269185.4_5'UTR|NOL4_ENST00000589544.1_Missense_Mutation_p.S114L|NOL4_ENST00000535475.1_5'UTR|NOL4_ENST00000538587.1_Missense_Mutation_p.S40L	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	114						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						CACATGCATCGAATAAATAAT	0.388000													8	26					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66826405	66826405	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:66826405G>T	ENST00000359742.4	-	14	1931	c.1691C>A	c.(1690-1692)tCt>tAt	p.S564Y	GRIP1_ENST00000398016.3_Missense_Mutation_p.S512Y|GRIP1_ENST00000286445.7_Missense_Mutation_p.S564Y			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	564					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TGGGATGACAGACTCTAATAT	0.328000													5	17					0.00116845	0.00122334	1	1	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													3	18					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248569809	248569809	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:248569809C>T	ENST00000366474.1	+	1	514	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGCCTATGACCGCTATGTGGC	0.532000													9	110					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51696557	51696557	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:51696557C>T	ENST00000409535.1	+	22	3650	c.3525C>T	c.(3523-3525)atC>atT	p.I1175I	RAD54L2_ENST00000296477.3_Silent_p.I869I	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	1175						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GCCCAGAGATCATCAGTGAGC	0.647000													9	37					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966826	41966826	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:41966826C>A	ENST00000298919.7	+	10	1853	c.1465C>A	c.(1465-1467)Ccg>Acg	p.P489T	PDZRN4_ENST00000539469.2_Missense_Mutation_p.P491T|PDZRN4_ENST00000402685.2_Missense_Mutation_p.P749T			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	749							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CAGAAGTACTCCGCTCACTGT	0.493000													11	78					1.08611e-07	1.22777e-07	1	1	0
PPP1CA	5499	broad.mit.edu	37	11	67167046	67167046	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:67167046A>C	ENST00000376745.4	-	4	657	c.509T>G	c.(508-510)tTc>tGc	p.F170C	PPP1CA_ENST00000532446.1_5'UTR|PPP1CA_ENST00000312989.7_Missense_Mutation_p.F181C|PPP1CA_ENST00000358239.4_Missense_Mutation_p.F126C	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	170					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GTGGCAGCAGAAGATCTTTTC	0.592000													7	37					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187419765	187419765	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr3:187419765T>G	ENST00000358241.1	-	1	580	c.152A>C	c.(151-153)cAc>cCc	p.H51P		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	51					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		GCCTGAGGCGTGCTGCTCCAG	0.622000													15	112					0	0	1	0	0
SLC52A1	55065	broad.mit.edu	37	17	4936857	4936857	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:4936857C>T	ENST00000512825.2	-	3	2338	c.927G>A	c.(925-927)ggG>ggA	p.G309G	SLC52A1_ENST00000254853.5_Silent_p.G309G|SLC52A1_ENST00000424747.1_Silent_p.G309G			Q9NWF4	RFT_HUMAN	solute carrier family 52 (riboflavin transporter), member 1	309						integral to plasma membrane	receptor activity|riboflavin transporter activity										AGGCCAGGCGCCCATAGGGCA	0.642000													23	30					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78355364	78355364	+	Silent	SNP	T	T	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:78355364T>A	ENST00000582970.1	+	57	13958	c.13815T>A	c.(13813-13815)atT>atA	p.I4605I	CTD-2047H16.4_ENST00000573394.1_RNA|RNF213_ENST00000336301.6_Silent_p.I2678I|RNF213_ENST00000508628.2_Silent_p.I4654I|CTD-2047H16.4_ENST00000572151.1_RNA|CTD-2047H16.4_ENST00000575034.1_RNA	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TAAACATCATTAAGCCTCCAG	0.547000													16	24					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74447538	74447538	+	Silent	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr16:74447538G>T	ENST00000339953.5	-	4	614	c.493C>A	c.(493-495)Cgg>Agg	p.R165R		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	165	SCP.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CACAGGTGCCGCCCACAGCCC	0.612000													6	106					0.0215528	0.0216918	1	1	0
TPCN1	53373	broad.mit.edu	37	12	113715134	113715134	+	Silent	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:113715134C>T	ENST00000550785.1	+	13	1534	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	TPCN1_ENST00000392569.4_Silent_p.F315F|TPCN1_ENST00000541517.1_Silent_p.F455F|TPCN1_ENST00000335509.6_Silent_p.F383F	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	383						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity	p.F383F(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						ATCTTACCTTCAAGGCCCTGA	0.582000													5	28					0	0	1	0	0
LYPD3	27076	broad.mit.edu	37	19	43967419	43967419	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr19:43967419G>T	ENST00000244333.3	-	4	491	c.403C>A	c.(403-405)Ccc>Acc	p.P135T		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	135						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				ACGCCGTTGGGCGGGTATGCA	0.637000													15	34					6.31663e-08	7.19266e-08	1	1	0
TRAV6	6956	broad.mit.edu	37	14	22237191	22237191	+	RNA	SNP	C	C	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr14:22237191C>A	ENST00000390428.3	+	0	275																											GCTACTCATACGTGAAAATGA	0.448000													16	65					6.72482e-11	7.8289e-11	1	1	0
OR11H12	440153	broad.mit.edu	37	14	19377698	19377698	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr14:19377698G>T	ENST00000550708.1	+	1	177	c.105G>T	c.(103-105)gaG>gaT	p.E35D		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCACTTGTGAGTGGACAATTC	0.433000													12	74					9.31168e-06	1.03023e-05	1	1	0
TRHDE	29953	broad.mit.edu	37	12	72969048	72969048	+	Silent	SNP	A	A	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:72969048A>C	ENST00000261180.4	+	11	2106	c.2010A>C	c.(2008-2010)atA>atC	p.I670I	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	670					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						ACCACAGAATAACTTATTTGG	0.338000													5	36					0	0	1	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40844735	40844735	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr17:40844735G>A	ENST00000264638.4	+	17	2966	c.2749G>A	c.(2749-2751)Gtg>Atg	p.V917M	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	917	Laminin G-like 3.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCCCCTCTATGTGGGTAAGCA	0.602000													18	22					0	0	1	0	0
CLIC4	25932	broad.mit.edu	37	1	25167425	25167425	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr1:25167425G>A	ENST00000374379.4	+	6	956	c.759G>A	c.(757-759)aaG>aaA	p.K253K		NM_013943.2	NP_039234.1	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	253					cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity			large_intestine(3)|lung(2)|skin(1)	6		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		GACTCACCAAGTAAAATCGCG	0.408000													9	70					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155528120	155528120	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr4:155528120G>A	ENST00000404648.3	-	8	1105	c.866C>T	c.(865-867)gCc>gTc	p.A289V	FGG_ENST00000407946.1_Missense_Mutation_p.A297V|FGG_ENST00000405164.1_Missense_Mutation_p.A297V|FGG_ENST00000336098.3_Missense_Mutation_p.A289V	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	289	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CTTGAACATGGCATAGTCTGC	0.493000													8	54					0	0	1	0	0
FBXO8	26269	broad.mit.edu	37	4	175183944	175183944	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr4:175183944G>A	ENST00000393674.2	-	2	1162	c.300C>T	c.(298-300)gaC>gaT	p.D100D	FBXO8_ENST00000503293.1_Silent_p.D59D	NM_012180.2	NP_036312.2	Q9NRD0	FBX8_HUMAN	F-box protein 8	100	F-box.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|urinary_tract(1)	14		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		CATTCGCAAGGTCCTGCCAAA	0.393000													4	30					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53645507	53645507	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr19:53645507G>C	ENST00000452676.2	-	5	1003	c.577C>G	c.(577-579)Ctg>Gtg	p.L193V	ZNF347_ENST00000334197.7_Missense_Mutation_p.L192V|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.L193V	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AGTTCAGGCAGATGTGACTGA	0.368000													11	72					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101215068	101215068	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr6:101215068T>A	ENST00000369162.2	-	9	1893	c.1549A>T	c.(1549-1551)Att>Ttt	p.I517F	ASCC3_ENST00000522650.1_Missense_Mutation_p.I517F	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	517	Helicase ATP-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TGTTGGCGAATTTCATGCAAG	0.348000													26	51					0	0	1	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27856133	27856133	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr7:27856133A>G	ENST00000396319.2	+	14	2018	c.1930A>G	c.(1930-1932)Aca>Gca	p.T644A	TAX1BP1_ENST00000409980.1_Missense_Mutation_p.T668A|TAX1BP1_ENST00000543117.1_Intron|TAX1BP1_ENST00000265393.6_Intron|TAX1BP1_ENST00000433216.2_Intron	NM_006024.6	NP_006015.4	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I) binding protein 1	644					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(8)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31			GBM - Glioblastoma multiforme(3;0.0823)			ATCTCAGGAAACAAGAGGTTA	0.343000													25	127					0	0	1	0	0
BMP3	651	broad.mit.edu	37	4	81967328	81967328	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr4:81967328G>A	ENST00000282701.2	+	2	1073	c.753G>A	c.(751-753)gaG>gaA	p.E251E		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	251					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						CCATTTCTGAGCCAGAAAGTG	0.483000													22	77					0	0	1	0	0
CPT1A	1374	broad.mit.edu	37	11	68582883	68582883	+	Silent	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr11:68582883G>A	ENST00000265641.5	-	2	214	c.60C>T	c.(58-60)gaC>gaT	p.D20D	CPT1A_ENST00000540367.1_Silent_p.D20D|CPT1A_ENST00000539743.1_Silent_p.D20D|CPT1A_ENST00000376618.2_Silent_p.D20D	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	20					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TCAGCCGCAGGTCAATCCCGT	0.463000													5	72					0	0	1	0	0
XRN2	22803	broad.mit.edu	37	20	21306917	21306917	+	Splice_Site	SNP	C	C	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr20:21306917C>T	ENST00000377191.3	+	2	171	c.75_splice	c.e2-1	p.P26_splice	XRN2_ENST00000539513.1_5'UTR|XRN2_ENST00000430571.2_Intron	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	26					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						TTCCTCATAGCCAAAAGAATG	0.333000													5	46					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134128920	134128920	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr8:134128920G>A	ENST00000220616.4	+	45	7862	c.7822G>A	c.(7822-7824)Gtc>Atc	p.V2608I	TG_ENST00000377869.1_Missense_Mutation_p.V2551I|TG_ENST00000542445.1_Missense_Mutation_p.V978I|TG_ENST00000519543.1_Missense_Mutation_p.V741I	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2608					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCGAGGAAACGTCTTCATGTA	0.512000													11	80					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36341934	36341934	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr19:36341934G>A	ENST00000378910.5	-	4	454	c.455C>T	c.(454-456)gCt>gTt	p.A152V	NPHS1_ENST00000353632.6_Missense_Mutation_p.A152V	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	152	Ig-like C2-type 2.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCTGCCCAGCTACCCAGGT	0.602000													3	42					0	0	1	0	0
SCRN3	79634	broad.mit.edu	37	2	175292538	175292549	+	In_Frame_Del	DEL	AGAAAATTGTTA	AGAAAATTGTTA	-			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr2:175292538_175292549delAGAAAATTGTTA	ENST00000272732.6	+	8	1272_1283	c.1190_1201delAGAAAATTGTTA	c.(1189-1203)gat>g	p.EKIVN397del	SCRN3_ENST00000409673.3_In_Frame_Del_p.EKIVN390del|SCRN3_ENST00000548921.1_3'UTR	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	397					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			CTTGATGTGGAGAAAATTGTTAATCTCTTTCC	0.321													8	30	---	---	---	---					
PTPRB	5787	broad.mit.edu	37	12	70983904	70983924	+	In_Frame_Del	DEL	GAGTAGGATCCGATACTGCTC	GAGTAGGATCCGATACTGCTC	-			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr12:70983904_70983924delGAGTAGGATCCGATACTGCTC	ENST00000334414.6	-	8	1914_1934	c.1870_1890delGAGCAGTATCGGATCCTACTC	c.(1870-1890)del	p.EQYRILL624del	PTPRB_ENST00000551525.1_In_Frame_Del_p.EQYRILL623del|PTPRB_ENST00000550857.1_Intron|PTPRB_ENST00000538708.1_In_Frame_Del_p.EQYRILL406del|PTPRB_ENST00000550358.1_In_Frame_Del_p.EQYRILL624del|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000451516.2_Intron|PTPRB_ENST00000261266.5_In_Frame_Del_p.EQYRILL406del	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	406	Fibronectin type-III 7.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.I410I(2)|p.R409R(2)|p.I628I(1)|p.R627R(1)|p.L412P(1)		breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AATCATTGAAGAGTAGGATCCGATACTGCTCCCAGTCTCCA	0.507											OREG0021990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	73	---	---	---	---					
PIBF1	10464	broad.mit.edu	37	13	73467972	73467973	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-A45X-01A-21D-A25D-08	TCGA-CV-A45X-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a0aa7be-5c98-48b3-b58b-a289643ed2e0	c9738e6d-fbef-41e4-98d5-3ed2934f18bd	g.chr13:73467972_73467973insT	ENST00000326291.6	+	11	1711_1712	c.1373_1374insT	c.(1372-1374)ccafs	p.P458fs		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	458						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GAATTTCTCCATCAAAGTAAAT	0.351													22	34	---	---	---	---					
