Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SSH2	85464	broad.mit.edu	37	17	27958126	27958126	+	Silent	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:27958126C>T	ENST00000269033.3	-	15	4156	c.4005G>A	c.(4003-4005)caG>caA	p.Q1335Q	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Silent_p.Q1362Q	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	1335					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTGGCTTGCTCTGCACAATAC	0.507000													4	54					0	0	0.000248	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870027	151870027	+	Missense_Mutation	SNP	C	C	G	rs144083108		TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:151870027C>G	ENST00000329342.5	+	3	942	c.717C>G	c.(715-717)ttC>ttG	p.F239L		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	239	MAGE.						protein binding	p.F239L(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGTATCTTCGGGGATCCCA	0.537000													10	124					0	0	0.006214	0	0
CHAMP1	283489	broad.mit.edu	37	13	115090169	115090169	+	Silent	SNP	A	A	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:115090169A>T	ENST00000361283.1	+	3	1161	c.852A>T	c.(850-852)tcA>tcT	p.S284S		NM_001164144.1|NM_001164145.1|NM_032436.2	NP_001157616.1|NP_001157617.1|NP_115812.1	Q96JM3	ZN828_HUMAN	chromosome alignment maintaining phosphoprotein 1	284	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding										CATCCCCTTCAGAGTCTCCTG	0.617000													5	73					0	0	0.001168	0	0
SPTA1	6708	broad.mit.edu	37	1	158627412	158627412	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:158627412C>A	ENST00000368148.3	-	19	2840	c.2660G>T	c.(2659-2661)cGa>cTa	p.R887L	SPTA1_ENST00000368147.3_Missense_Mutation_p.R887L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	887					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCTAGCAGCTCGAGCACGGAG	0.473000													6	140					0.00198382	0.00249728	0.001984	1	0
ZMAT1	84460	broad.mit.edu	37	X	101138797	101138797	+	Silent	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:101138797A>G	ENST00000458570.1	-	9	2419	c.1089T>C	c.(1087-1089)caT>caC	p.H363H	ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000540921.1_Silent_p.H534H|ZMAT1_ENST00000372782.3_Silent_p.H534H			A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	363						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						GTTTCTGTTTATGACCTGCTT	0.383000													4	51					0	0	0.000602	0	0
BOLA3	388962	broad.mit.edu	37	2	74362737	74362737	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:74362737A>G	ENST00000327428.5	-	4	426	c.307T>C	c.(307-309)Tct>Cct	p.S103P	BOLA3_ENST00000295326.4_Missense_Mutation_p.L73P	NM_212552.2	NP_997717.2	Q53S33	BOLA3_HUMAN	bolA family member 3	103						extracellular region				large_intestine(1)|lung(1)	2						TTGGGGACAGAGGTAAATATC	0.428000													3	67					0	0	0.000602	0	0
PIWIL1	9271	broad.mit.edu	37	12	130831541	130831541	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr12:130831541C>A	ENST00000245255.3	+	6	859	c.587C>A	c.(586-588)aCt>aAt	p.T196N		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	196					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATAACGATCACTTTAACAAAT	0.348000													5	49					0.00116845	0.00150631	0.001168	1	0
LUZP1	7798	broad.mit.edu	37	1	23419092	23419092	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:23419092C>A	ENST00000302291.4	-	4	2464	c.1663G>T	c.(1663-1665)Gct>Tct	p.A555S	LUZP1_ENST00000314174.5_Missense_Mutation_p.A555S|LUZP1_ENST00000374623.3_Missense_Mutation_p.A555S|LUZP1_ENST00000418342.1_Missense_Mutation_p.A555S			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	555						nucleus				NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		GAGTTTGCAGCCTGAGTTACT	0.537000													4	97					0.000602214	0.000795518	0.000602	1	0
CSMD1	64478	broad.mit.edu	37	8	4494966	4494966	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:4494966C>G	ENST00000520002.1	-	2	755	c.200G>C	c.(199-201)cGc>cCc	p.R67P	CSMD1_ENST00000542608.1_Missense_Mutation_p.R67P|CSMD1_ENST00000539096.1_Missense_Mutation_p.R67P|CSMD1_ENST00000537824.1_Missense_Mutation_p.R67P|CSMD1_ENST00000602723.1_Missense_Mutation_p.R67P|CSMD1_ENST00000602557.1_Missense_Mutation_p.R67P|CSMD1_ENST00000400186.3_Missense_Mutation_p.R67P			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	67	CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATCCTATTGCGCTCGCCCGT	0.468000													4	101					0	0	0.000248	0	0
OR9A4	130075	broad.mit.edu	37	7	141618783	141618783	+	Silent	SNP	G	G	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:141618783G>A	ENST00000548136.1	+	1	167	c.108G>A	c.(106-108)gtG>gtA	p.V36V	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TCTACTTGGTGACATTAATGG	0.428000													6	157					0	0	0.001984	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994645	140994645	+	Silent	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:140994645C>T	ENST00000285879.4	+	4	1741	c.1455C>T	c.(1453-1455)tcC>tcT	p.S485S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	485							protein binding	p.S485S(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGCTCCTCCTCCTCCTCCT	0.478000										HNSCC(15;0.026)			7	126					0	0	0.001984	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43522928	43522928	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:43522928C>A	ENST00000430334.3	-	9	2878	c.2745G>T	c.(2743-2745)atG>atT	p.M915I	PLEKHM1_ENST00000580404.1_5'UTR|PLEKHM1_ENST00000421073.2_Missense_Mutation_p.M826I	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1	915					intracellular signal transduction	cytoplasm	metal ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					CAATGAGGTGCATCCGCTCCA	0.612000													6	75					0.00448238	0.00551281	0.004482	1	0
ZNF658	26149	broad.mit.edu	37	9	40774387	40774387	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:40774387G>C	ENST00000602553.1	-	5	1182	c.888C>G	c.(886-888)caC>caG	p.H296Q	ZNF658_ENST00000377626.3_Missense_Mutation_p.H296Q|ZNF658_ENST00000441795.1_Missense_Mutation_p.H294Q			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TACACTCATAGTGTGTCATAG	0.403000													18	167					0	0	0.005443	0	0
NDUFAF3	25915	broad.mit.edu	37	3	49060398	49060398	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:49060398G>T	ENST00000326925.6	+	4	1561	c.427G>T	c.(427-429)Gtg>Ttg	p.V143L	NDUFAF3_ENST00000395458.2_Missense_Mutation_p.V86L|NDUFAF3_ENST00000326912.4_Missense_Mutation_p.V86L|NDUFAF3_ENST00000451378.2_Missense_Mutation_p.V86L	NM_199069.1	NP_951032.1	Q9BU61	NDUF3_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3	143					mitochondrial respiratory chain complex I assembly	mitochondrial inner membrane|nucleus	protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)	8						TGCTGTGGAAGTGCAGGACAC	0.637000													4	95					0.00024832	0.000336332	0.000248	1	0
SLC47A1	55244	broad.mit.edu	37	17	19470127	19470127	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:19470127G>T	ENST00000270570.4	+	13	1217	c.1131G>T	c.(1129-1131)caG>caT	p.Q377H	SLC47A1_ENST00000571335.1_Missense_Mutation_p.Q182H|SLC47A1_ENST00000457293.1_Missense_Mutation_p.Q377H|SLC47A1_ENST00000395585.1_Missense_Mutation_p.Q377H|SLC47A1_ENST00000436810.2_Missense_Mutation_p.Q354H|RP11-1113L8.1_ENST00000574267.1_RNA|SLC47A1_ENST00000575023.1_Intron	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	377						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TGGTGGCTCAGGTGGTTCCAA	0.418000													5	57					0.00116845	0.00150631	0.001168	1	0
HRC	3270	broad.mit.edu	37	19	49657229	49657229	+	Silent	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:49657229G>C	ENST00000252825.4	-	1	1452	c.1266C>G	c.(1264-1266)gtC>gtG	p.V422V	HRC_ENST00000595625.1_Silent_p.V422V	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	422					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CCTCCCTGGGGACTCTGTGGT	0.537000													3	93					0	0	0.004672	0	0
NUMB	8650	broad.mit.edu	37	14	73745999	73745999	+	Silent	SNP	G	G	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:73745999G>A	ENST00000556772.1	-	6	3085	c.798C>T	c.(796-798)gcC>gcT	p.A266A	NUMB_ENST00000560335.1_Intron|NUMB_ENST00000356296.4_Intron|NUMB_ENST00000559312.1_Intron|NUMB_ENST00000355058.3_Silent_p.A410A|NUMB_ENST00000544991.3_Intron|NUMB_ENST00000555394.1_Intron|NUMB_ENST00000454166.4_Intron|NUMB_ENST00000555738.2_Intron|NUMB_ENST00000555238.1_Silent_p.A410A|NUMB_ENST00000554546.1_Intron|NUMB_ENST00000554521.2_Intron|NUMB_ENST00000535282.1_Silent_p.A399A|NUMB_ENST00000557597.1_Silent_p.A399A|NUMB_ENST00000359560.3_Silent_p.A399A			P49757	NUMB_HUMAN	numb homolog (Drosophila)	410					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		CCGAACATGTGGCTGCAATTT	0.527000													4	71					0	0	0.000602	0	0
DCHS2	54798	broad.mit.edu	37	4	155278384	155278384	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:155278384G>C	ENST00000357232.3	-	6	786	c.787C>G	c.(787-789)Cta>Gta	p.L263V	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	263	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		aagtgccttagcagaggtaaa	0.398000													11	136					0	0	0.000978	0	0
PIK3CA	5290	broad.mit.edu	37	3	178947827	178947827	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:178947827G>T	ENST00000263967.3	+	19	2859	c.2702G>T	c.(2701-2703)tGt>tTt	p.C901F		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	901	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.C901F(7)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACACGTTCATGTGCTGGATAC	0.388000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	174					2.48551e-13	3.54599e-13	0.004990	1	0
SLC24A1	9187	broad.mit.edu	37	15	65936825	65936825	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:65936825A>G	ENST00000261892.6	+	5	2401	c.2114A>G	c.(2113-2115)cAg>cGg	p.Q705R	SLC24A1_ENST00000449142.2_3'UTR|SLC24A1_ENST00000339868.6_Missense_Mutation_p.Q687R|SLC24A1_ENST00000546330.1_Missense_Mutation_p.Q687R|SLC24A1_ENST00000399033.4_Missense_Mutation_p.Q705R|SLC24A1_ENST00000537259.1_Missense_Mutation_p.Q687R|SLC24A1_ENST00000544319.2_Intron	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	705					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GCCCAACCCCAGGCCAAAGCA	0.547000													2	6					0	0	0.004672	0	0
MT1JP	4498	broad.mit.edu	37	16	56670369	56670369	+	RNA	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr16:56670369C>T	ENST00000564564.1	+	0	695																											TGCACGTGCGCCGGCTCCTGC	0.577000													6	63					0	0	0.001168	0	0
MYH6	4624	broad.mit.edu	37	14	23863348	23863348	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:23863348G>T	ENST00000405093.3	-	21	2684	c.2614C>A	c.(2614-2616)Cgc>Agc	p.R872S	MYH6_ENST00000356287.3_Missense_Mutation_p.R872S	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	872					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle	p.R872C(1)		breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGCTCCTTGCGGCGAGCCTCG	0.592000													9	81					1.04858e-14	1.51618e-14	0.006214	1	0
ADAM19	8728	broad.mit.edu	37	5	156934137	156934137	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:156934137A>G	ENST00000257527.4	-	10	995	c.917T>C	c.(916-918)tTc>tCc	p.F306S	ADAM19_ENST00000517905.1_Missense_Mutation_p.F306S|ADAM19_ENST00000394020.1_Missense_Mutation_p.F308S|ADAM19_ENST00000430702.2_Missense_Mutation_p.F39S	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	306	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGCCGTGGAAGGACATGCC	0.617000													3	80					0	0	0.004672	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280605	105280605	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:105280605C>T	ENST00000327674.4	-	1	780	c.445G>A	c.(445-447)Gat>Aat	p.D149N	SERPINA7_ENST00000372563.1_Missense_Mutation_p.D149N			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	149					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	GTCTTGACATCATTCAAGAAC	0.428000													6	95					0	0	0.001984	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53217477	53217477	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:53217477A>T	ENST00000342657.3	+	7	1923	c.850A>T	c.(850-852)Aga>Tga	p.R284*	HNRNPA1L2_ENST00000398039.1_Nonsense_Mutation_p.R284*|HNRNPA1L2_ENST00000357495.2_Nonsense_Mutation_p.R284*	NM_001011724.1	NP_001011724.1	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like 2	284	Gly-rich.|Nuclear targeting sequence (By similarity).				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding			cervix(1)|large_intestine(1)|lung(5)	7						TTTTGGAGGCAGAAGCTCTGG	0.478000													5	101					0	0	0.000978	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43522926	43522926	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:43522926T>G	ENST00000430334.3	-	9	2880	c.2747A>C	c.(2746-2748)cAc>cCc	p.H916P	PLEKHM1_ENST00000580404.1_5'UTR|PLEKHM1_ENST00000421073.2_Missense_Mutation_p.H827P	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1	916					intracellular signal transduction	cytoplasm	metal ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					CCCAATGAGGTGCATCCGCTC	0.617000													6	73					0	0	0.004482	0	0
RUFY2	55680	broad.mit.edu	37	10	70141060	70141060	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:70141060T>C	ENST00000388768.2	-	11	1467	c.1141A>G	c.(1141-1143)Act>Gct	p.T381A	RUFY2_ENST00000399200.2_Missense_Mutation_p.T312A|RUFY2_ENST00000454950.2_Missense_Mutation_p.T288A|RUFY2_ENST00000472394.2_5'UTR|RUFY2_ENST00000602465.1_Missense_Mutation_p.T346A	NM_017987.4	NP_060457.4	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain containing 2	395						nucleus	metal ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)	20						CCTATCAGAGTATCTTGTTTC	0.363000													9	101					0	0	0.006214	0	0
SEMA3C	10512	broad.mit.edu	37	7	80546045	80546045	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:80546045C>T	ENST00000265361.3	-	2	614	c.53G>A	c.(52-54)tGt>tAt	p.C18Y	SEMA3C_ENST00000487621.1_5'UTR|SEMA3C_ENST00000536800.1_De_novo_Start_InFrame|SEMA3C_ENST00000419255.2_Missense_Mutation_p.C18Y|SEMA3C_ENST00000544525.1_Missense_Mutation_p.C36Y	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	18					immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TCCTTTCACACAGATAGAACA	0.348000													9	54					0	0	0.000978	0	0
CERS3	204219	broad.mit.edu	37	15	101016321	101016321	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:101016321T>A	ENST00000284382.4	-	9	1002	c.579A>T	c.(577-579)ttA>ttT	p.L193F	CERS3_ENST00000394113.1_Missense_Mutation_p.L193F|CERS3_ENST00000538112.2_Missense_Mutation_p.L193F|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	193	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CAAGTCTAAATAACAGAGACC	0.363000													7	97					0	0	0.003080	0	0
GPR139	124274	broad.mit.edu	37	16	20043921	20043921	+	Silent	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr16:20043921G>C	ENST00000570682.1	-	2	498	c.198C>G	c.(196-198)ctC>ctG	p.L66L		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	66						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CGAGTGCCAAGAGATAGTTGT	0.468000													3	44					0	0	0.004672	0	0
EXTL1	2134	broad.mit.edu	37	1	26349468	26349468	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:26349468C>G	ENST00000374280.3	+	1	1198	c.331C>G	c.(331-333)Cat>Gat	p.H111D		NM_004455.2	NP_004446.2	Q92935	EXTL1_HUMAN	exostosin-like glycosyltransferase 1	111					skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|stomach(1)|urinary_tract(1)	23		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTGAGACTCATCGCAGGAT	0.577000													5	58					0	0	0.000602	0	0
FAP	2191	broad.mit.edu	37	2	163039967	163039967	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:163039967T>G	ENST00000188790.4	-	21	2033	c.1826A>C	c.(1825-1827)gAa>gCa	p.E609A	FAP_ENST00000443424.1_Missense_Mutation_p.E584A	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	609					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						GAAACCCATTTCTATGAATTT	0.284000													4	81					0	0	0.000248	0	0
CSMD3	114788	broad.mit.edu	37	8	113249436	113249436	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:113249436A>T	ENST00000297405.5	-	67	10854	c.10610T>A	c.(10609-10611)aTg>aAg	p.M3537K	CSMD3_ENST00000455883.2_Missense_Mutation_p.M3368K|CSMD3_ENST00000343508.3_Missense_Mutation_p.M3497K|CSMD3_ENST00000352409.3_Missense_Mutation_p.M3467K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3537						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAGCAGCTCCATGTTGCTATT	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	94					0	0	0.000248	0	0
NID2	22795	broad.mit.edu	37	14	52508964	52508964	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:52508964C>T	ENST00000216286.5	-	7	1683	c.1684G>A	c.(1684-1686)Gat>Aat	p.D562N	NID2_ENST00000541773.1_Missense_Mutation_p.D509N	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	562	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GCTCTGCCATCATTGCCCACG	0.597000													16	198					0	0	0.004007	0	0
SSX6	280657	broad.mit.edu	37	X	47972589	47972589	+	Translation_Start_Site	SNP	G	G	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:47972589G>A	ENST00000319275.3	+	0	366				SSX6_ENST00000376932.2_Silent_p.Q98Q																large_intestine(6)|lung(4)|skin(2)|stomach(1)	13						AACGTCCTCAGATGACTTTTG	0.448000													9	101					0	0	0.000978	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110450456	110450456	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr11:110450456C>T	ENST00000260283.4	-	16	3498	c.3214G>A	c.(3214-3216)Gag>Aag	p.E1072K	ARHGAP20_ENST00000528829.1_Missense_Mutation_p.E1036K|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.E1046K|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.E1046K|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.E1049K|ARHGAP20_ENST00000529591.1_Missense_Mutation_p.E615K|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.E1036K	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1072					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GGGGGTGGCTCTAAGGGTCCT	0.498000													7	159					0	0	0.004482	0	0
SHARPIN	81858	broad.mit.edu	37	8	145154650	145154650	+	Silent	SNP	C	C	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:145154650C>G	ENST00000398712.2	-	4	1051	c.615G>C	c.(613-615)ctG>ctC	p.L205L	SHARPIN_ENST00000533948.1_5'UTR	NM_030974.3	NP_112236.3	Q9H0F6	SHRPN_HUMAN	SHANK-associated RH domain interactor	205	Interaction with SHANK1 (By similarity).				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(2)|ovary(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTGAACACTCAGGGCCACAC	0.652000													3	74					0	0	0.000248	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76067930	76067930	+	RNA	SNP	C	C	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:76067930C>A	ENST00000395215.3	+	0	37																											TGGAGGTGTTCGCTGATGTGG	0.537000													5	60					3.59834e-05	4.93618e-05	0.001168	1	0
PCDHB2	56133	broad.mit.edu	37	5	140476001	140476001	+	Silent	SNP	T	T	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:140476001T>C	ENST00000194155.4	+	1	1775	c.1627T>C	c.(1627-1629)Ttg>Ctg	p.L543L		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		543	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCCGGCGTTGAGCAGCGA	0.706000													6	89					0	0	0.004482	0	0
RIMS1	22999	broad.mit.edu	37	6	72968708	72968708	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr6:72968708C>T	ENST00000264839.7	+	18	2947	c.2947C>T	c.(2947-2949)Cca>Tca	p.P983S	RIMS1_ENST00000518273.1_Missense_Mutation_p.P983S|RIMS1_ENST00000523963.1_Missense_Mutation_p.P457S|RIMS1_ENST00000491071.2_Missense_Mutation_p.P983S|RIMS1_ENST00000517960.1_Missense_Mutation_p.P982S|RIMS1_ENST00000517827.1_Missense_Mutation_p.P442S|RIMS1_ENST00000538414.1_5'UTR|RIMS1_ENST00000425662.2_Missense_Mutation_p.P376S|RIMS1_ENST00000522291.1_Missense_Mutation_p.P982S|RIMS1_ENST00000401910.3_Missense_Mutation_p.P456S|RIMS1_ENST00000348717.5_Missense_Mutation_p.P982S|RIMS1_ENST00000521978.1_Missense_Mutation_p.P983S|RIMS1_ENST00000520567.1_Missense_Mutation_p.P982S			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	983					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGAAATTCATCCAACAAGAAG	0.388000													6	90					0	0	0.001168	0	0
LPPR1	54886	broad.mit.edu	37	9	104075140	104075140	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:104075140C>A	ENST00000374874.3	+	6	1136	c.697C>A	c.(697-699)Ctc>Atc	p.L233I	LPPR1_ENST00000395056.2_Missense_Mutation_p.L233I	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		233						integral to membrane	catalytic activity										GGTGCTGTGCCTCGGAACTCT	0.567000													10	94					0.00136819	0.00174282	0.001368	1	0
PCDHGA4	56111	broad.mit.edu	37	5	140734835	140734835	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:140734835T>C	ENST00000571252.1	+	1	68	c.68T>C	c.(67-69)cTg>cCg	p.L23P	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGGGGTTCTGGTGGAAATC	0.637000													6	73					0	0	0.001168	0	0
ATP5G3	518	broad.mit.edu	37	2	176043850	176043850	+	Silent	SNP	T	T	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:176043850T>C	ENST00000284727.4	-	4	3273	c.249A>G	c.(247-249)gtA>gtG	p.V83V	ATP5G3_ENST00000392541.3_Silent_p.V83V|ATP5G3_ENST00000409194.1_Silent_p.V83V	NM_001002258.4|NM_001689.4	NP_001002258.1|NP_001680.1	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)	83					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.147)			CAGCCACTCCTACTGTTGCAG	0.443000													3	67					0	0	0.004672	0	0
USP53	54532	broad.mit.edu	37	4	120169908	120169908	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:120169908A>G	ENST00000450251.1	+	3	787	c.243A>G	c.(241-243)atA>atG	p.I81M	USP53_ENST00000274030.6_Missense_Mutation_p.I81M			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	81					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						CCCAGACGATATTTGCACAGT	0.378000													4	49					0	0	0.000248	0	0
HUWE1	10075	broad.mit.edu	37	X	53571698	53571698	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:53571698T>G	ENST00000342160.3	-	71	11531	c.11074A>C	c.(11074-11076)Att>Ctt	p.I3692L	HUWE1_ENST00000474288.1_5'UTR|HUWE1_ENST00000262854.6_Missense_Mutation_p.I3692L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3692					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GATGCCACAATTACCACATTC	0.483000													4	39					0	0	0.000248	0	0
PXDNL	137902	broad.mit.edu	37	8	52320759	52320759	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:52320759A>G	ENST00000356297.4	-	17	3525	c.3425T>C	c.(3424-3426)aTt>aCt	p.I1142T	PXDNL_ENST00000543296.1_Missense_Mutation_p.I1142T	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1142					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACCCCTTTGAATGATGGTGGC	0.493000													5	122					0	0	0.001984	0	0
CASKIN2	57513	broad.mit.edu	37	17	73499583	73499583	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:73499583G>T	ENST00000321617.3	-	17	2292	c.1706C>A	c.(1705-1707)gCa>gAa	p.A569E	CASKIN2_ENST00000433559.2_Missense_Mutation_p.A487E	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	569	SAM 2.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCCCCAGTGCACACAGCCA	0.642000													4	41					1.024e-07	1.44168e-07	0.000602	1	0
CSMD3	114788	broad.mit.edu	37	8	113662433	113662433	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:113662433G>T	ENST00000297405.5	-	19	3394	c.3150C>A	c.(3148-3150)tgC>tgA	p.C1050*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.C946*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.C1010*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.C1050*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1050	Sushi 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GGTTTTTTTCGCATAGAAGGG	0.393000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	90					0.000602214	0.000795518	0.000602	1	0
RFXAP	5994	broad.mit.edu	37	13	37399599	37399599	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:37399599A>C	ENST00000255476.2	+	2	769	c.635A>C	c.(634-636)cAa>cCa	p.Q212P	RFXAP_ENST00000472888.1_3'UTR	NM_000538.3	NP_000529.1	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	212						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		ATTGTTAAACAAAGAACAGGA	0.318000													4	81					0	0	0.000602	0	0
SENP5	205564	broad.mit.edu	37	3	196612189	196612189	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:196612189G>A	ENST00000323460.5	+	2	386	c.137G>A	c.(136-138)aGg>aAg	p.R46K	SENP5_ENST00000445299.2_Missense_Mutation_p.R46K|SENP5_ENST00000419026.1_Intron	NM_152699.4	NP_689912.2	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	46					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(14)|skin(1)	32	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AAGCTGGGAAGGCCAGTTACT	0.413000													4	46					0	0	0.000602	0	0
ALPK2	115701	broad.mit.edu	37	18	56203268	56203268	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr18:56203268T>C	ENST00000361673.3	-	5	4364	c.4151A>G	c.(4150-4152)gAt>gGt	p.D1384G	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1384							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GGCAGTGTGATCCATCTTGAG	0.428000													4	118					0	0	0.001984	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55048220	55048220	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:55048220G>C	ENST00000335056.3	+	5	825	c.787G>C	c.(787-789)Gga>Cga	p.G263R	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GGTTGCTCATGGACAGTGGCT	0.557000													4	94					0	0	0.000602	0	0
CD8A	925	broad.mit.edu	37	2	87013080	87013080	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:87013080G>T	ENST00000409511.2	-	9	1701	c.671C>A	c.(670-672)tCg>tAg	p.S224*	CD8A_ENST00000456996.2_Nonsense_Mutation_p.S187*|CD8A_ENST00000283635.3_Nonsense_Mutation_p.S224*|CD8A_ENST00000352580.3_Nonsense_Mutation_p.S187*|CD8A_ENST00000538832.1_Nonsense_Mutation_p.S265*|CD8A_ENST00000409781.1_Nonsense_Mutation_p.S187*	NM_001145873.1	NP_001139345.1	P01732	CD8A_HUMAN	CD8a molecule	224					antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	8						CTTGTCTCCCGATTTGACCAC	0.547000													7	163					5.18039e-06	7.19873e-06	0.003080	1	0
ATF6	22926	broad.mit.edu	37	1	161928411	161928411	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:161928411C>G	ENST00000367942.3	+	16	2047	c.1980C>G	c.(1978-1980)caC>caG	p.H660Q		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	660					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			AGGCAACCCACGTTGTCAGCA	0.522000													5	112					0	0	0.000602	0	0
THEG	51298	broad.mit.edu	37	19	371324	371324	+	Splice_Site	SNP	T	T	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:371324T>A	ENST00000342640.4	-	6	678		c.e6-2		THEG_ENST00000346878.2_Splice_Site	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein						cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGTCGTCCTGGGGGAGGTC	0.582000													6	163					0	0	0.004482	0	0
RYR2	6262	broad.mit.edu	37	1	237777923	237777923	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:237777923G>C	ENST00000366574.2	+	37	5812	c.5495G>C	c.(5494-5496)gGc>gCc	p.G1832A	RYR2_ENST00000360064.6_Missense_Mutation_p.G1830A|RYR2_ENST00000542537.1_Missense_Mutation_p.G1816A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1832	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGATCATGGGCATCTTTCAC	0.502000													5	160					0	0	0.001168	0	0
DNAH14	127602	broad.mit.edu	37	1	225155247	225155247	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:225155247A>G	ENST00000430092.1	+	6	828	c.613A>G	c.(613-615)Aaa>Gaa	p.K205E	DNAH14_ENST00000439375.2_Missense_Mutation_p.K205E|DNAH14_ENST00000366850.3_Missense_Mutation_p.K205E|DNAH14_ENST00000366848.1_Missense_Mutation_p.K205E|DNAH14_ENST00000400952.3_Missense_Mutation_p.K205E|DNAH14_ENST00000366849.1_Intron	NM_001373.1	NP_001364.1	Q0VDD8	DYH14_HUMAN	dynein, axonemal, heavy chain 14	332					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(2)|lung(2)|skin(2)|stomach(1)	27						TAAACATTGCAAAGAATTTTG	0.323000													7	71					0	0	0.001984	0	0
NPTX2	4885	broad.mit.edu	37	7	98254269	98254269	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:98254269G>C	ENST00000265634.3	+	3	844	c.679G>C	c.(679-681)Gtg>Ctg	p.V227L		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	227	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TGCGTTCAAGGTGTCCCTCCC	0.607000													19	226					0	0	0.007413	0	0
STXBP2	6813	broad.mit.edu	37	19	7709561	7709561	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:7709561T>C	ENST00000441779.2	+	14	1239	c.1202T>C	c.(1201-1203)gTt>gCt	p.V401A	STXBP2_ENST00000414284.2_Missense_Mutation_p.V387A|STXBP2_ENST00000221283.5_Missense_Mutation_p.V390A	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	390					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						AAGCTGATCGTTCCGGTGCTG	0.652000													4	53					0	0	0.000248	0	0
SLC6A14	11254	broad.mit.edu	37	X	115582641	115582641	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:115582641C>T	ENST00000371900.4	+	8	1053	c.965C>T	c.(964-966)tCc>tTc	p.S322F		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	322					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	ATATTTTACTCCCTTTCAGTG	0.318000													5	46					0	0	0.001168	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	38					0	0	0.000248	0	0
DENND2D	79961	broad.mit.edu	37	1	111742266	111742266	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:111742266T>C	ENST00000357640.4	-	2	451	c.222A>G	c.(220-222)atA>atG	p.I74M	DENND2D_ENST00000369752.5_Missense_Mutation_p.I71M|DENND2D_ENST00000473682.1_5'UTR	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	74	UDENN.									breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GGTAGGTGATTATAGGCTCGT	0.522000													11	156					0	0	0.008291	0	0
FREM2	341640	broad.mit.edu	37	13	39358893	39358893	+	Silent	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:39358893C>T	ENST00000280481.7	+	6	6183	c.5967C>T	c.(5965-5967)atC>atT	p.I1989I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1989					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGGGAAGAATCGGATCAGAGT	0.448000													4	39					0	0	0.000248	0	0
OR2L8	391190	broad.mit.edu	37	1	248112599	248112599	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:248112599C>T	ENST00000357191.3	+	1	440	c.440C>T	c.(439-441)tCt>tTt	p.S147F	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ATAACAGGGTCTTGGATCATA	0.438000													8	167					0	0	0.008291	0	0
PDE1C	5137	broad.mit.edu	37	7	31862847	31862847	+	Silent	SNP	G	G	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:31862847G>A	ENST00000396184.3	-	15	1626	c.1422C>T	c.(1420-1422)agC>agT	p.S474S	PDE1C_ENST00000396191.1_Silent_p.S474S|PDE1C_ENST00000321453.7_Silent_p.S474S|PDE1C_ENST00000396193.1_Silent_p.S534S|PDE1C_ENST00000396182.2_Silent_p.S474S	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	474	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CATCTGACGAGCTGATGCTAT	0.438000													4	54					0	0	0.000248	0	0
GBP4	115361	broad.mit.edu	37	1	89655859	89655859	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:89655859C>G	ENST00000355754.6	-	7	1156	c.1059G>C	c.(1057-1059)atG>atC	p.M353I		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	353						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		GTTGCTGGGCCATCTGCTGGC	0.602000													4	57					0	0	0.000248	0	0
TTN	7273	broad.mit.edu	37	2	179399269	179399269	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:179399269C>G	ENST00000589042.1	-	358	102297	c.102073G>C	c.(102073-102075)Gag>Cag	p.E34025Q	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E25085Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E32384Q|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E31457Q|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E25152Q|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E24960Q|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000450692.2_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32384	Ig-like 150.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATATTCTCAATGATCTGT	0.413000													3	103					0	0	0.004672	0	0
IGHV3-16	28447	broad.mit.edu	37	14	106622313	106622313	+	RNA	SNP	A	A	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:106622313A>T	ENST00000390604.2	-	0	106																											TTAAAATACCAGCAAGAAAAA	0.448000													7	109					0	0	0.003080	0	0
RAB33B	83452	broad.mit.edu	37	4	140394046	140394046	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:140394046G>C	ENST00000305626.5	+	2	845	c.456G>C	c.(454-456)ttG>ttC	p.L152F		NM_031296.1	NP_112586.1	Q9H082	RB33B_HUMAN	RAB33B, member RAS oncogene family	152					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	4	all_hematologic(180;0.162)					AATGTGACTTGAGAAGTGCCA	0.398000													4	126					0	0	0.000248	0	0
FGF7	2252	broad.mit.edu	37	15	49776562	49776562	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:49776562A>G	ENST00000267843.4	+	4	1057	c.446A>G	c.(445-447)aAc>aGc	p.N149S	FGF7_ENST00000560704.1_3'UTR|FAM227B_ENST00000299338.6_Intron|FAM227B_ENST00000561064.1_Intron	NM_002009.3	NP_002000.1	P21781	FGF7_HUMAN	fibroblast growth factor 7	149					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	AACCATTACAACACATATGCA	0.328000													3	47					0	0	0.004672	0	0
CPOX	1371	broad.mit.edu	37	3	98304334	98304334	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:98304334C>T	ENST00000264193.2	-	5	1341	c.1123G>A	c.(1123-1125)Gac>Aac	p.D375N		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	375						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						GTGAATGAGTCATCACAGTGC	0.517000													7	234					0	0	0.001984	0	0
FCN1	2219	broad.mit.edu	37	9	137801651	137801651	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:137801651G>T	ENST00000371806.3	-	9	1065	c.974C>A	c.(973-975)cCc>cAc	p.P325H		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	325	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CGTCTAGGCGGGCCGCACCTT	0.592000													8	73					0.00307968	0.00383169	0.003080	1	0
THSD7B	80731	broad.mit.edu	37	2	137928343	137928343	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:137928343G>A	ENST00000409968.1	+	7	1736	c.1558G>A	c.(1558-1560)Gaa>Aaa	p.E520K	THSD7B_ENST00000413152.2_Missense_Mutation_p.E489K|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000272643.3_Missense_Mutation_p.E520K					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGTCCTCATGGAATCTACAGG	0.473000													4	60					0	0	0.000602	0	0
TRIM58	25893	broad.mit.edu	37	1	248023998	248023998	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:248023998A>G	ENST00000366481.3	+	2	548	c.500A>G	c.(499-501)aAg>aGg	p.K167R		NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	167						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTGGGGAAAAAGACTGTCATT	0.478000													5	72					0	0	0.001168	0	0
GRIN3A	116443	broad.mit.edu	37	9	104448991	104448991	+	Silent	SNP	T	T	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:104448991T>G	ENST00000361820.3	-	2	1791	c.1191A>C	c.(1189-1191)gcA>gcC	p.A397A		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	397					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTACAGCTCTTGCGACCAGCT	0.498000													14	69					0	0	0.001855	0	0
PARD3	56288	broad.mit.edu	37	10	34673066	34673066	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:34673066C>T	ENST00000374789.3	-	8	1332	c.1007G>A	c.(1006-1008)aGa>aAa	p.R336K	PARD3_ENST00000340077.5_Missense_Mutation_p.R336K|PARD3_ENST00000374773.1_Missense_Mutation_p.R336K|PARD3_ENST00000545693.1_Missense_Mutation_p.R336K|PARD3_ENST00000374776.1_Missense_Mutation_p.R336K|PARD3_ENST00000374788.3_Missense_Mutation_p.R336K|PARD3_ENST00000545260.1_Missense_Mutation_p.R292K|PARD3_ENST00000544292.1_Missense_Mutation_p.R66K|PARD3_ENST00000374790.3_Missense_Mutation_p.R292K|PARD3_ENST00000374794.3_Missense_Mutation_p.R292K|PARD3_ENST00000350537.4_Missense_Mutation_p.R336K|PARD3_ENST00000346874.4_Missense_Mutation_p.R336K	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	336	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				CTGTTCAAATCTTCTATTTCG	0.398000													4	60					0	0	0.001168	0	0
SOGA3	387104	broad.mit.edu	37	6	127796926	127796926	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr6:127796926delG	ENST00000556132.1	-	6	3109	c.2245delC	c.(2245-2247)gcfs	p.R749fs	SOGA3_ENST00000481848.2_Frame_Shift_Del_p.R749fs|SOGA3_ENST00000368268.2_Frame_Shift_Del_p.R749fs|SOGA3_ENST00000465909.2_Frame_Shift_Del_p.R749fs|SOGA3_ENST00000525778.1_Frame_Shift_Del_p.R749fs	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	749						integral to membrane											TCGCTGTCGCGGGGGCTGCCG	0.692													9	165	---	---	---	---					
SP8	221833	broad.mit.edu	37	7	20824941	20824943	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:20824941_20824943delGCC	ENST00000361443.4	-	3	676_678	c.439_441delGGC	c.(439-441)del	p.G147del	SP8_ENST00000418710.2_In_Frame_Del_p.G165del	NM_198956.2	NP_945194.1	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G165delG(1)|p.G147delG(1)		NS(1)|central_nervous_system(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	8						GCGCGGAGGAgccgccgccgccg	0.729													7	10	---	---	---	---					
DRGX	644168	broad.mit.edu	37	10	50574313	50574313	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:50574313delG	ENST00000374139.2	-	6	650	c.640delC	c.(640-642)gcfs	p.R214fs	DRGX_ENST00000434016.1_Frame_Shift_Del_p.R219fs			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	219					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						GAGTGCTCGCGGGCCTTCATG	0.672													11	111	---	---	---	---					
LMTK3	114783	broad.mit.edu	37	19	49014769	49014769	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:49014769delG	ENST00000600059.1	-	1	292	c.65delC	c.(64-66)cgfs	p.P22fs	LMTK3_ENST00000270238.3_Frame_Shift_Del_p.P51fs					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGGGTGGGCCGGGGACGCCAG	0.741													2	4	---	---	---	---					
