Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADAP2	55803	broad.mit.edu	37	17	29272068	29272068	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:29272068G>A	ENST00000330889.3	+	6	989	c.654G>A	c.(652-654)ggG>ggA	p.G218G	ADAP2_ENST00000580525.1_Silent_p.G224G	NM_018404.2	NP_060874.1	Q9NPF8	ADAP2_HUMAN	ArfGAP with dual PH domains 2	218	PH 1.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						ATGAAAGTGGGAAGGTGAGAT	0.592000													14	31					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86493637	86493637	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:86493637G>A	ENST00000361669.2	+	6	3705	c.2606G>A	c.(2605-2607)cGg>cAg	p.R869Q	GRM3_ENST00000536043.1_Missense_Mutation_p.R741Q|GRM3_ENST00000394720.2_Silent_p.A511A|GRM3_ENST00000546348.1_Missense_Mutation_p.R461Q|GRM3_ENST00000439827.1_Silent_p.A513A	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	869					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGCAATGGGCGGGAAGTCCTC	0.473000													31	87					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71200025	71200025	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr14:71200025C>G	ENST00000554752.2	-	11	2060	c.2061G>C	c.(2059-2061)gaG>gaC	p.E687D	MAP3K9_ENST00000554146.1_Missense_Mutation_p.E415D|MAP3K9_ENST00000381250.4_Missense_Mutation_p.E664D|MAP3K9_ENST00000555993.2_Missense_Mutation_p.E701D|MAP3K9_ENST00000553414.1_Missense_Mutation_p.E420D			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	687					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		gtaggcgactctctccactcc	0.532000													5	28					0	0	1	0	0
CECR6	27439	broad.mit.edu	37	22	17601203	17601203	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr22:17601203G>T	ENST00000331437.3	-	1	940	c.815C>A	c.(814-816)cCg>cAg	p.P272Q	CECR6_ENST00000399875.1_Intron	NM_031890.3	NP_114096.1	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	272	Ala-rich.									haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		ATGCAGGGGCGGCGCGGCGTG	0.806000													8	23					2.74318e-10	3.03121e-10	1	1	0
POM121	9883	broad.mit.edu	37	7	72413745	72413745	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:72413745C>T	ENST00000395270.1	+	14	3459	c.2418C>T	c.(2416-2418)tcC>tcT	p.S806S	POM121_ENST00000257622.4_Silent_p.S806S|POM121_ENST00000446813.1_Silent_p.S806S|POM121_ENST00000358357.3_Silent_p.S806S|POM121_ENST00000434423.2_Silent_p.S1071S	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1071	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CCACCAGCTCCGGCTTTGGAG	0.657000													8	90					0	0	1	0	0
HIST1H4B	8366	broad.mit.edu	37	6	26027344	26027344	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:26027344C>T	ENST00000377364.3	-	1	136	c.137G>A	c.(136-138)cGa>cAa	p.R46Q		NM_003544.2	NP_003535.1	P62805	H4_HUMAN	histone cluster 1, H4b	46					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding	p.R46Q(1)		large_intestine(4)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	13						ACCGGAAATTCGCTTAACCCC	0.572000													12	85					0	0	1	0	0
UCHL5	51377	broad.mit.edu	37	1	192998768	192998768	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:192998768G>C	ENST00000367455.3	-	4	501	c.266C>G	c.(265-267)gCt>gGt	p.A89G	UCHL5_ENST00000367452.4_5'UTR|UCHL5_ENST00000367448.1_Missense_Mutation_p.A89G|UCHL5_ENST00000367451.4_Missense_Mutation_p.A89G|UCHL5_ENST00000367449.1_Missense_Mutation_p.A89G|UCHL5_ENST00000530098.2_5'UTR|UCHL5_ENST00000367454.1_Missense_Mutation_p.A89G	NM_015984.3	NP_057068.1	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	89					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(1)|lung(9)|ovary(1)	19						GGCTTGAGTAGCACAAGCATT	0.323000													5	26					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129870815	129870815	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr9:129870815T>C	ENST00000373425.3	-	2	813	c.196A>G	c.(196-198)Acg>Gcg	p.T66A	ANGPTL2_ENST00000373417.1_Intron|RALGPS1_ENST00000259351.5_Intron|RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000373436.1_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	66					multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						ATGGCACCCGTGACCCGCTGC	0.572000													15	54					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48129715	48129715	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr20:48129715C>T	ENST00000244043.4	-	8	1137	c.1108G>A	c.(1108-1110)Gca>Aca	p.A370T	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	370					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CGCCCGTCTGCCATGGGCATG	0.617000													51	70					0	0	1	0	0
PSPH	5723	broad.mit.edu	37	7	56082733	56082733	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:56082733C>T	ENST00000395471.3	-	7	1358	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	PSPH_ENST00000275605.3_Missense_Mutation_p.E185K|PSPH_ENST00000459834.1_5'UTR			P78330	SERB_HUMAN	phosphoserine phosphatase	185					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GGACAGGCTTCCATATCTGTG	0.289000													16	72					0	0	1	0	0
TAPBP	6892	broad.mit.edu	37	6	33272235	33272235	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:33272235G>A	ENST00000434618.2	-	5	1394	c.1049C>T	c.(1048-1050)tCg>tTg	p.S350L	TAPBP_ENST00000489157.1_Missense_Mutation_p.S263L|TAPBP_ENST00000456592.2_Missense_Mutation_p.S350L|TAPBP_ENST00000426633.2_Missense_Mutation_p.S350L|TAPBP_ENST00000475304.1_Missense_Mutation_p.S368L	NM_003190.4|NM_172209.2	NP_003181.3|NP_757346.2	O15533	TPSN_HUMAN	TAP binding protein (tapasin)	350	Ig-like C1-type.				antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			endometrium(2)|large_intestine(5)|lung(8)|ovary(3)	18						GCGCAGGGCCGAGAGCCACCT	0.677000													11	60					0	0	1	0	0
GNPTAB	79158	broad.mit.edu	37	12	102158696	102158696	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:102158696C>T	ENST00000299314.7	-	13	2261	c.1999G>A	c.(1999-2001)Gag>Aag	p.E667K		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	667					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						GGAATATCCTCAAAAAGGATT	0.428000													5	53					0	0	1	0	0
ZFP30	22835	broad.mit.edu	37	19	38126661	38126661	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:38126661G>C	ENST00000351218.2	-	6	1338	c.781C>G	c.(781-783)Caa>Gaa	p.Q261E	ZFP30_ENST00000514101.2_Missense_Mutation_p.Q261E|ZFP30_ENST00000392144.1_Missense_Mutation_p.Q261E|ZFP30_ENST00000589018.1_Intron	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGAATCCTTTGATGGAGATTA	0.423000													14	76					0	0	1	0	0
RP11-483E23.2	0	broad.mit.edu	37	15	28600002	28600002	+	RNA	SNP	T	T	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr15:28600002T>A	ENST00000568624.1	-	0	404																											TTCGTATGGTTTGAACCTGGG	0.493000													4	67					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11101923	11101923	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:11101923G>A	ENST00000358026.2	+	8	1627	c.1343G>A	c.(1342-1344)cGc>cAc	p.R448H	SMARCA4_ENST00000589677.1_Missense_Mutation_p.R448H|SMARCA4_ENST00000590574.1_Missense_Mutation_p.R448H|SMARCA4_ENST00000541122.2_Missense_Mutation_p.R448H|SMARCA4_ENST00000444061.3_Missense_Mutation_p.R448H|SMARCA4_ENST00000450717.3_Missense_Mutation_p.R448H|SMARCA4_ENST00000413806.3_Missense_Mutation_p.R448H|SMARCA4_ENST00000344626.4_Missense_Mutation_p.R448H|SMARCA4_ENST00000429416.3_Missense_Mutation_p.R448H	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	448					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CAGTCCCTGCGCGAGGCCCGC	0.657000			"""F, N, Mis"""		NSCLC								6	38					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183913418	183913418	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:183913418C>A	ENST00000361927.4	-	10	1680	c.1309G>T	c.(1309-1311)Gac>Tac	p.D437Y	COLGALT2_ENST00000367521.1_Missense_Mutation_p.D45Y|COLGALT2_ENST00000546159.1_Missense_Mutation_p.D437Y|COLGALT2_ENST00000367520.3_Missense_Mutation_p.D174Y	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		CGCACATCGTCTTCAATTACA	0.403000													5	97					0.184627	0.184627	1	1	0
ZBED1	9189	broad.mit.edu	37	X	2408255	2408255	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chrX:2408255G>C	ENST00000381223.4	-	2	709	c.506C>G	c.(505-507)tCt>tGt	p.S169C	DHRSX_ENST00000334651.5_Intron|ZBED1_ENST00000381218.3_Missense_Mutation_p.S169C|ZBED1_ENST00000381222.2_Missense_Mutation_p.S169C	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	169						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCCTTGGTAGAGATGTACTT	0.642000													52	145					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10920159	10920159	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr21:10920159G>T	ENST00000298232.7	-	18	1408	c.1041C>A	c.(1039-1041)agC>agA	p.S347R	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.S365R|TPTE_ENST00000342420.5_Missense_Mutation_p.S327R	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	365	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATAATACAGGCTTTCCTACA	0.388000													5	73					5.9392e-07	6.37167e-07	1	1	0
FOXN3	1112	broad.mit.edu	37	14	89747335	89747335	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr14:89747335G>A	ENST00000345097.4	-	4	820	c.704C>T	c.(703-705)cCg>cTg	p.P235L	FOXN3_ENST00000557258.1_Missense_Mutation_p.P235L|FOXN3_ENST00000261302.5_Missense_Mutation_p.P235L|FOXN3_ENST00000555658.1_5'UTR|FOXN3_ENST00000555353.1_Missense_Mutation_p.P235L	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	235					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GGTACTGCCCGGCCAGATGGG	0.542000													3	40					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167089911	167089911	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:167089911G>A	ENST00000375387.4	-	21	4206	c.3866C>T	c.(3865-3867)tCc>tTc	p.S1289F	SCN9A_ENST00000409672.1_Missense_Mutation_p.S1277F|SCN9A_ENST00000409435.1_Missense_Mutation_p.S1288F|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Missense_Mutation_p.S1289F			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1288						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGTCCGAAGGGATTTAATGGG	0.323000													5	29					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49742512	49742512	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:49742512C>T	ENST00000327697.6	+	23	2199	c.2055C>T	c.(2053-2055)ctC>ctT	p.L685L	RNF123_ENST00000432042.1_Silent_p.L539L	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	685						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		ACCGCTTCCTCAGCACAGCGG	0.687000													7	13					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157556153	157556153	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:157556153C>T	ENST00000271532.1	-	6	1075	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	314	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CCTGTGCCTTCAGCCACGGAG	0.612000													6	122					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274446	39274446	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:39274446C>T	ENST00000391413.2	-	1	160	c.122G>A	c.(121-123)cGc>cAc	p.R41H		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	41	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGCTGGGGCGACAGTAGGT	0.667000													41	55					0	0	1	0	0
TSPAN4	7106	broad.mit.edu	37	11	864504	864504	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:864504C>T	ENST00000397404.1	+	5	582	c.323C>T	c.(322-324)aCg>aTg	p.T108M	TSPAN4_ENST00000397406.1_Missense_Mutation_p.T108M|TSPAN4_ENST00000397408.1_Missense_Mutation_p.T108M|TSPAN4_ENST00000525201.1_Missense_Mutation_p.T44M|TSPAN4_ENST00000397411.2_Missense_Mutation_p.T108M|TSPAN4_ENST00000346501.4_Missense_Mutation_p.T108M|TSPAN4_ENST00000397397.2_Missense_Mutation_p.T108M|TSPAN4_ENST00000409531.1_Missense_Mutation_p.T127M|TSPAN4_ENST00000409543.2_Missense_Mutation_p.T108M|TSPAN4_ENST00000397396.1_Missense_Mutation_p.T44M	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	108					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTCGCCTACACGGACAAGGTA	0.657000													18	82					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62550927	62550927	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr14:62550927C>T	ENST00000430451.2	+	5	1645	c.1448C>T	c.(1447-1449)cCg>cTg	p.P483L		NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	483										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGAGGGTCTCCGCTCAGCCCA	0.517000													17	70					0	0	1	0	0
TGDS	23483	broad.mit.edu	37	13	95243181	95243181	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr13:95243181G>C	ENST00000261296.5	-	4	359	c.239C>G	c.(238-240)tCt>tGt	p.S80C	TGDS_ENST00000498294.1_5'UTR	NM_014305.2	NP_055120.1	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	80					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					CACAAAGTGAGAATCACATAT	0.353000													17	70					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17030559	17030559	+	RNA	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:17030559G>C	ENST00000492551.1	-	0	776					NR_026567.1																						CCGTGGTGTTGGGTGAGGACA	0.627000													19	94					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125877269	125877269	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:125877269C>T	ENST00000393434.2	-	3	690	c.341G>A	c.(340-342)cGa>cAa	p.R114Q	ALDH1L1_ENST00000472186.1_Missense_Mutation_p.R114Q|ALDH1L1_ENST00000455064.2_Intron|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.R124Q|ALDH1L1_ENST00000393431.2_Missense_Mutation_p.R114Q|ALDH1L1_ENST00000452905.2_Missense_Mutation_p.R114Q	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	114	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CGAGGCCCCTCGGTGCCTAGG	0.577000													3	18					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39768535	39768535	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:39768535G>A	ENST00000301653.4	-	1	470	c.406C>T	c.(406-408)Cgt>Tgt	p.R136C		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	136	Coil 1A.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				TCCAGAGCACGCACCTTGTCC	0.577000													4	185					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158516916	158516916	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:158516916G>A	ENST00000355585.4	+	27	4086	c.4011G>A	c.(4009-4011)aaG>aaA	p.K1337K	SYNJ2_ENST00000367122.2_Silent_p.K1292K|SYNJ2_ENST00000367112.1_Silent_p.K422K	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	1337							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CGAGGAGGAAGAAGTCAGCCC	0.647000													22	89					0	0	1	0	0
PLCD1	5333	broad.mit.edu	37	3	38049775	38049775	+	Silent	SNP	G	G	A	rs143935807		TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:38049775G>A	ENST00000463876.1	-	13	2402	c.2049C>T	c.(2047-2049)ggC>ggT	p.G683G	PLCD1_ENST00000334661.4_Silent_p.G662G	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	662	C2.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CCCGGCTCACGCCATGGATCT	0.567000													43	124					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63410190	63410190	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chrX:63410190T>A	ENST00000330258.3	-	2	3249	c.2977A>T	c.(2977-2979)Acc>Tcc	p.T993S	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									ATGCAACAGGTTGCCTGCCTA	0.567000													10	22					0	0	1	0	0
RPL18A	6142	broad.mit.edu	37	19	17972909	17972909	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:17972909G>C	ENST00000600147.1	+	3	241	c.205G>C	c.(205-207)Gag>Cag	p.E69Q	RPL18A_ENST00000599898.1_Missense_Mutation_p.E30Q|RPL18A_ENST00000222247.5_Missense_Mutation_p.E69Q|RPL18A_ENST00000599870.1_Missense_Mutation_p.E40Q			Q02543	RL18A_HUMAN	ribosomal protein L18a	69					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(1)	5						GCAGGTGTTTGAGAAGTCCCC	0.607000													16	46					0	0	1	0	0
CAPS2	84698	broad.mit.edu	37	12	75706697	75706697	+	Splice_Site	SNP	T	T	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:75706697T>A	ENST00000393284.3	-	7	554		c.e7-2		CAPS2_ENST00000409445.3_Splice_Site|CAPS2_ENST00000442339.2_Splice_Site|CAPS2_ENST00000409799.1_Splice_Site|CAPS2_ENST00000409004.1_Splice_Site			Q9BXY5	CAYP2_HUMAN	calcyphosine 2								calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						CACAATTTCCTGGGAAGATTA	0.343000													5	24					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75556586	75556586	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr10:75556586A>G	ENST00000604729.1	+	16	3385	c.3088A>G	c.(3088-3090)Agt>Ggt	p.S1030G	ZSWIM8_ENST00000398706.2_Missense_Mutation_p.S1030G|ZSWIM8_ENST00000603114.1_Missense_Mutation_p.S992G|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.S1025G|NDST2_ENST00000456638.1_5'UTR|ZSWIM8_ENST00000604524.1_Missense_Mutation_p.S1025G					zinc finger, SWIM-type containing 8																		ACAGACGCTGAGTTCTTTCTA	0.567000													13	99					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153659173	153659173	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:153659173G>A	ENST00000368680.3	+	11	2282	c.1810G>A	c.(1810-1812)Gac>Aac	p.D604N		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	604	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	AGCCTGCACCGACCCCCCCAA	0.592000													30	142					0	0	1	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28454850	28454850	+	Silent	SNP	T	T	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:28454850T>A	ENST00000383768.2	+	3	479	c.291T>A	c.(289-291)ccT>ccA	p.P97P	ZCWPW2_ENST00000421010.1_Silent_p.P97P			Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	97							zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(6)|ovary(2)	17						CACAGCTCCCTCTTGGAAGCC	0.363000													13	131					0	0	1	0	0
SKI	6497	broad.mit.edu	37	1	2235348	2235348	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:2235348G>A	ENST00000378536.4	+	4	1353	c.1281G>A	c.(1279-1281)caG>caA	p.Q427Q		NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	427					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		CGGCCCAGCAGAAGGTTGTGA	0.687000													5	22					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151904466	151904466	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:151904466G>A	ENST00000355193.2	-	24	3978	c.3760C>T	c.(3760-3762)Cgg>Tgg	p.R1254W	KMT2C_ENST00000262189.6_Missense_Mutation_p.R1254W					lysine (K)-specific methyltransferase 2C																		ACAGCTTCCCGCTCAGGACTA	0.383000													4	72					0	0	1	0	0
CX3CL1	6376	broad.mit.edu	37	16	57416888	57416888	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr16:57416888C>A	ENST00000565912.1	+	2	3730	c.1024C>A	c.(1024-1026)Ctt>Att	p.L342I	CX3CL1_ENST00000563383.1_Missense_Mutation_p.L386I|CX3CL1_ENST00000006053.6_Missense_Mutation_p.L380I			P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1	380					cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GGCGGAGGGCCTTCGCTACAT	0.587000													19	103					5.03518e-11	5.62008e-11	1	1	0
OLFML1	283298	broad.mit.edu	37	11	7530749	7530749	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:7530749G>A	ENST00000329293.3	+	3	933	c.539G>A	c.(538-540)gGa>gAa	p.G180E	OLFML1_ENST00000530135.1_Missense_Mutation_p.G180E|OLFML1_ENST00000528758.1_3'UTR|CTD-2516F10.2_ENST00000530201.1_RNA	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	180	Olfactomedin-like.					extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		TTATTAATTGGATCCAGAAAC	0.423000													28	95					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152954850	152954850	+	Silent	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:152954850G>C	ENST00000539935.1	-	2	208	c.141C>G	c.(139-141)ctC>ctG	p.L47L	CACNB4_ENST00000201943.5_Silent_p.L47L|CACNB4_ENST00000427385.1_Silent_p.L29L|AC079790.2_ENST00000420365.1_RNA	NM_000726.3|NM_001145798.1	NP_000717.2|NP_001139270.1	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	47					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	ATACCTGTCTGAGGATGAAGC	0.677000													5	147					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123908403	123908403	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr9:123908403G>C	ENST00000373855.1	+	23	3588	c.3328G>C	c.(3328-3330)Gaa>Caa	p.E1110Q	CNTRL_ENST00000373850.1_Missense_Mutation_p.E558Q|CNTRL_ENST00000238341.5_Missense_Mutation_p.E1110Q|CNTRL_ENST00000373847.1_Missense_Mutation_p.E558Q			Q7Z7A1	CNTRL_HUMAN	centriolin	1110					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						AGGAGGCTTTGAAAATGTTTT	0.338000													10	33					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133153535	133153535	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr8:133153535G>C	ENST00000388996.4	-	10	1726	c.1306C>G	c.(1306-1308)Cgt>Ggt	p.R436G	KCNQ3_ENST00000521134.1_Missense_Mutation_p.R316G|KCNQ3_ENST00000519445.1_Missense_Mutation_p.R436G	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	436					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTGCTACCACGAGGATTAGAA	0.398000													34	70					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100866145	100866145	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr8:100866145G>C	ENST00000358544.2	+	56	10714	c.10603G>C	c.(10603-10605)Gac>Cac	p.D3535H	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.D3510H	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3535					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATACGTGGAAGACACATTTGT	0.418000													37	388					0	0	1	0	0
CHN1	1123	broad.mit.edu	37	2	175677211	175677211	+	Splice_Site	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:175677211C>G	ENST00000409900.3	-	9	1026		c.e9-1		CHN1_ENST00000409156.3_Splice_Site|CHN1_ENST00000409597.1_Splice_Site|CHN1_ENST00000295497.7_Splice_Site|CHN1_ENST00000488080.1_Splice_Site	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			AAACCACAATCTAAGAAAAGA	0.368000			T	TAF15	extraskeletal myxoid chondrosarcoma								12	48					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31855619	31855619	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:31855619C>G	ENST00000396184.3	-	16	1936	c.1732G>C	c.(1732-1734)Gga>Cga	p.G578R	PDE1C_ENST00000396191.1_Missense_Mutation_p.G578R|PDE1C_ENST00000321453.7_Missense_Mutation_p.G578R|PDE1C_ENST00000396182.2_Missense_Mutation_p.G578R|PDE1C_ENST00000479980.1_5'UTR|PDE1C_ENST00000396193.1_Missense_Mutation_p.G638R	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	578					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GCCCGTGTTCCATTGACTTGA	0.473000													20	228					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11206869	11206869	+	Silent	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chrX:11206869C>G	ENST00000337414.4	-	4	1928	c.1056G>C	c.(1054-1056)ccG>ccC	p.P352P	ARHGAP6_ENST00000413512.3_Silent_p.P161P|ARHGAP6_ENST00000534860.1_Silent_p.P177P|ARHGAP6_ENST00000380736.1_Silent_p.P149P|ARHGAP6_ENST00000380718.1_Silent_p.P352P|ARHGAP6_ENST00000380732.3_Silent_p.P384P|ARHGAP6_ENST00000303025.6_Silent_p.P149P	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	352					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CCCGAGGAGCCGGTTCCGGGG	0.468000													19	33					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193382668	193382668	+	Splice_Site	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:193382668G>A	ENST00000361510.2	+	27	2895		c.e27-1		OPA1_ENST00000361150.2_Splice_Site|OPA1_ENST00000361908.3_Splice_Site|OPA1_ENST00000361828.2_Splice_Site|OPA1_ENST00000361715.2_Splice_Site|OPA1_ENST00000392438.3_Splice_Site	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)						apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TCTCATTTTAGATTAAGGATA	0.303000													6	48					0	0	1	0	0
NAP1L1	4673	broad.mit.edu	37	12	76449836	76449836	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:76449836C>T	ENST00000261182.8	-	7	1021	c.535G>A	c.(535-537)Gac>Aac	p.D179N	NAP1L1_ENST00000393263.3_Missense_Mutation_p.D179N|NAP1L1_ENST00000535020.2_Missense_Mutation_p.D179N|NAP1L1_ENST00000552342.1_Missense_Mutation_p.D190N|NAP1L1_ENST00000548044.1_Missense_Mutation_p.D138N|NAP1L1_ENST00000549596.1_Missense_Mutation_p.D179N|NAP1L1_ENST00000431879.3_Missense_Mutation_p.D111N|NAP1L1_ENST00000542344.1_Missense_Mutation_p.D137N|NAP1L1_ENST00000547773.1_Missense_Mutation_p.D116N|NAP1L1_ENST00000544816.1_5'UTR|NAP1L1_ENST00000547993.1_5'UTR	NM_004537.4|NM_139207.2	NP_004528.1|NP_631946.1	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	179					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	9		Colorectal(145;0.09)				CTGAGCAAGTCAACATTCTTA	0.328000													14	57					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44596466	44596466	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr20:44596466C>T	ENST00000322927.2	-	5	821	c.721G>A	c.(721-723)Gtg>Atg	p.V241M	ZNF335_ENST00000426788.1_Missense_Mutation_p.V86M|ZNF335_ENST00000494955.1_5'UTR	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TGCTGCACCACCACCACCTCC	0.667000													39	51					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349394	65349394	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65349394G>C	ENST00000309295.4	+	9	1516	c.1251G>C	c.(1249-1251)gaG>gaC	p.E417D		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	417										central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						AGGCTGAAGAGAGTTCAGCAG	0.567000													9	43					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	29					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79770487	79770487	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr5:79770487C>G	ENST00000338008.5	+	17	4479	c.4299C>G	c.(4297-4299)ttC>ttG	p.F1433L	ZFYVE16_ENST00000510158.1_Missense_Mutation_p.F1433L|ZFYVE16_ENST00000505560.1_Missense_Mutation_p.F1433L	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1433					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TTCAGGTGTTCTACTTTCTAA	0.333000													4	60					0	0	1	0	0
LIMA1	51474	broad.mit.edu	37	12	50616264	50616264	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:50616264G>A	ENST00000341247.4	-	4	319	c.170C>T	c.(169-171)aCc>aTc	p.T57I	LIMA1_ENST00000552783.1_5'UTR|LIMA1_ENST00000394943.3_Missense_Mutation_p.T57I|RP3-405J10.4_ENST00000551284.1_RNA	NM_001113546.1|NM_016357.4	NP_001107018.1|NP_057441.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	57					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						GAGATTTTCGGTGTTCTAGAA	0.433000													24	87					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996126	19996126	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr18:19996126C>G	ENST00000391403.2	-	1	1752	c.1649G>C	c.(1648-1650)aGg>aCg	p.R550T		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	550						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					ATCAGTTAACCTATCACAGCT	0.537000													16	115					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466571	56466571	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:56466571G>C	ENST00000291971.3	+	3	1218	c.1147G>C	c.(1147-1149)Gcc>Ccc	p.A383P	NLRP8_ENST00000590542.1_Missense_Mutation_p.A383P	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	383	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTTGAGTTTCGCCATGGAAAA	0.468000													31	99					0	0	1	0	0
VPS45	11311	broad.mit.edu	37	1	150048364	150048364	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:150048364G>A	ENST00000369130.3	+	4	889	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	VPS45_ENST00000535106.1_Missense_Mutation_p.E115K|VPS45_ENST00000369128.5_Missense_Mutation_p.E79K	NM_007259.3	NP_009190.2	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45 homolog (S. cerevisiae)	115					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGAAGCTGATGAACAGGAAGT	0.383000													42	87					0	0	1	0	0
STAT5A	6776	broad.mit.edu	37	17	40461401	40461401	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:40461401G>A	ENST00000345506.4	+	19	2763	c.2121G>A	c.(2119-2121)gtG>gtA	p.V707V	STAT5A_ENST00000546010.2_Silent_p.V677V|STAT5A_ENST00000588868.1_Silent_p.V676V|STAT5A_ENST00000590949.1_Silent_p.V707V|STAT5A_ENST00000452307.2_Silent_p.V704V|STAT5A_ENST00000587646.1_Silent_p.V195V	NM_003152.3	NP_003143.2	P42229	STA5A_HUMAN	signal transducer and activator of transcription 5A	707					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		GCAGGTTTGTGAATGCATCTG	0.617000													6	43					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098960	178098960	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:178098960C>A	ENST00000397062.3	-	2	639	c.85G>T	c.(85-87)Gat>Tat	p.D29Y	NFE2L2_ENST00000464747.1_Missense_Mutation_p.D13Y|NFE2L2_ENST00000446151.2_Missense_Mutation_p.D13Y|NFE2L2_ENST00000423513.1_Missense_Mutation_p.D13Y|NFE2L2_ENST00000397063.4_Missense_Mutation_p.D13Y	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	29					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.D29H(11)|p.D29N(2)|p.D29Y(2)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTCCAAGATCTATATCTTGC	0.363000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			9	34					7.48243e-07	7.98849e-07	1	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136785	40136785	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:40136785G>A	ENST00000278198.2	-	2	3021	c.1058C>T	c.(1057-1059)gCt>gTt	p.A353V	LRRC4C_ENST00000527150.1_Missense_Mutation_p.A353V|LRRC4C_ENST00000530763.1_Missense_Mutation_p.A353V|LRRC4C_ENST00000528697.1_Missense_Mutation_p.A353V			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	353	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AATCACCGGAGCATAGCATGT	0.542000													18	75					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26802572	26802572	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr10:26802572G>T	ENST00000376236.4	+	8	1251	c.796G>T	c.(796-798)Gta>Tta	p.V266L		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	266					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						GAAATATGCTGTATTTAAAAA	0.333000													13	88					5.50884e-06	5.76992e-06	1	1	0
OR14A16	284532	broad.mit.edu	37	1	247978594	247978594	+	Silent	SNP	A	A	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:247978594A>T	ENST00000357627.1	-	1	437	c.438T>A	c.(436-438)tcT>tcA	p.S146S		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	146					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						CATACAGCCAAGACACAGTGG	0.502000													12	179					0	0	1	0	0
SLC25A22	79751	broad.mit.edu	37	11	792392	792392	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:792392C>T	ENST00000320230.5	-	8	1135	c.654G>A	c.(652-654)gcG>gcA	p.A218A	SLC25A22_ENST00000531214.1_Silent_p.A218A	NM_001191061.1|NM_024698.5	NP_001177990.1|NP_078974.1	Q9H936	GHC1_HUMAN	solute carrier family 25 (mitochondrial carrier: glutamate), member 22	218						integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity			endometrium(1)|kidney(1)|lung(2)|urinary_tract(1)	5		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	TCTCCTCGGACGCCGGGCGGC	0.657000													46	189					0	0	1	0	0
WDR92	116143	broad.mit.edu	37	2	68358543	68358543	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:68358543C>T	ENST00000295121.6	-	8	1017	c.901G>A	c.(901-903)Gag>Aag	p.E301K	WDR92_ENST00000492039.2_5'UTR	NM_138458.3	NP_612467.1	Q96MX6	WDR92_HUMAN	WD repeat domain 92	301					apoptosis|histone lysine methylation		methylated histone residue binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|stomach(1)	12						TCTATTCCCTCAGAATCTTTC	0.393000													6	92					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35747697	35747697	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr13:35747697T>C	ENST00000540320.1	+	27	5054	c.4520T>C	c.(4519-4521)gTt>gCt	p.V1507A	NBEA_ENST00000379939.2_Missense_Mutation_p.V1504A|NBEA_ENST00000310336.4_Missense_Mutation_p.V1507A|NBEA_ENST00000400445.3_Missense_Mutation_p.V1507A			Q8NFP9	NBEA_HUMAN	neurobeachin	1507						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CCTCAGGAAGTTCCTCAAAGT	0.373000													7	54					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39114738	39114738	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr8:39114738G>A	ENST00000379907.4	+	19	2165	c.2038G>A	c.(2038-2040)Gaa>Aaa	p.E680K	ADAM32_ENST00000437682.2_Missense_Mutation_p.E581K|ADAM32_ENST00000519315.1_Missense_Mutation_p.E574K	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	680					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGGGAAGACTGAAAACACCTG	0.343000													5	51					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142089455	142089455	+	Missense_Mutation	SNP	T	T	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:142089455T>G	ENST00000264951.4	-	27	3193	c.3076A>C	c.(3076-3078)Aaa>Caa	p.K1026Q	XRN1_ENST00000392981.2_Missense_Mutation_p.K1026Q	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1026					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TCTTGAACTTTTTCAGCACTA	0.269000													4	35					0	0	1	0	0
C20orf195	79025	broad.mit.edu	37	20	62187169	62187169	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr20:62187169C>T	ENST00000370098.3	+	2	245	c.153C>T	c.(151-153)ttC>ttT	p.F51F	C20orf195_ENST00000370097.1_Silent_p.F51F	NM_024059.2	NP_076964.1	Q9BVV2	CT195_HUMAN	chromosome 20 open reading frame 195	51										large_intestine(3)|lung(4)	7	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			TGCGTGAGTTCCTGACCTCGG	0.637000													21	54					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544355	115544355	+	Silent	SNP	C	C	T	rs137983750		TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr4:115544355C>T	ENST00000310836.6	+	2	841	c.319C>T	c.(319-321)Ctg>Ttg	p.L107L	UGT8_ENST00000394511.3_Silent_p.L107L	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	107					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		GTTTGACATACTGGATCACTA	0.458000													4	112					0	0	1	0	0
UCHL5	51377	broad.mit.edu	37	1	193028340	193028340	+	Silent	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:193028340G>C	ENST00000367455.3	-	1	286	c.51C>G	c.(49-51)gtC>gtG	p.V17V	UCHL5_ENST00000367452.4_Intron|UCHL5_ENST00000367448.1_Silent_p.V17V|UCHL5_ENST00000367451.4_Silent_p.V17V|UCHL5_ENST00000483156.1_5'UTR|UCHL5_ENST00000367449.1_Silent_p.V17V|UCHL5_ENST00000530098.2_5'UTR|UCHL5_ENST00000367454.1_Silent_p.V17V	NM_015984.3	NP_057068.1	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	17					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(1)|lung(9)|ovary(1)	19						GCTCGGTGAAGACCCCGGGGT	0.662000													7	36					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34204889	34204889	+	Silent	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:34204889G>T	ENST00000373381.4	-	15	2396	c.2220C>A	c.(2218-2220)ggC>ggA	p.G740G		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	700	Sushi 4.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CAAACCGTTTGCCATTTACTG	0.547000													18	77					2.94398e-08	3.23692e-08	1	1	0
XRN1	54464	broad.mit.edu	37	3	142078708	142078708	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:142078708T>C	ENST00000264951.4	-	30	3577	c.3460A>G	c.(3460-3462)Ata>Gta	p.I1154V	XRN1_ENST00000392981.2_Missense_Mutation_p.I1154V	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1154					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						ACAAACCTTATTGTTAACCCT	0.328000													5	43					0	0	1	0	0
TSPAN10	83882	broad.mit.edu	37	17	79612378	79612378	+	RNA	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:79612378G>A	ENST00000328585.4	+	0	487				TSPAN10_ENST00000572675.1_RNA	NM_031945.3	NP_114151.3	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GGTGGTCAGCGCAGTGAGCCT	0.672000													4	12					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157514217	157514217	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:157514217G>A	ENST00000361835.3	-	5	836	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C	FCRL5_ENST00000368189.3_Missense_Mutation_p.R227C|FCRL5_ENST00000368190.3_Missense_Mutation_p.R227C|FCRL5_ENST00000368191.3_Missense_Mutation_p.R142C|FCRL5_ENST00000356953.4_Missense_Mutation_p.R227C	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	227	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CTGAAGAAGCGGAACCGGAGC	0.562000													43	229					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65350805	65350805	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65350805G>T	ENST00000309295.4	+	9	2927	c.2662G>T	c.(2662-2664)Gaa>Taa	p.E888*		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	888	Glu-rich.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						GGGGGTCCAGGAAGCAGAGAC	0.517000													7	51					0.0477658	0.048202	1	1	0
NFAT5	10725	broad.mit.edu	37	16	69727125	69727125	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr16:69727125C>G	ENST00000349945.1	+	14	4667	c.3115C>G	c.(3115-3117)Cca>Gca	p.P1039A	NFAT5_ENST00000567239.1_Missense_Mutation_p.P1132A|NFAT5_ENST00000566899.1_Missense_Mutation_p.P1039A|NFAT5_ENST00000354436.2_Missense_Mutation_p.P1115A|NFAT5_ENST00000432919.1_Missense_Mutation_p.P1133A|NFAT5_ENST00000393742.2_Missense_Mutation_p.P1039A	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1115					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AATGCAGCCTCCAATGTTTCA	0.443000													25	191					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630065	9630065	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr5:9630065A>T	ENST00000382492.2	-	1	398	c.80T>A	c.(79-81)aTt>aAt	p.I27N	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	27					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						CACCACCACAATGATGCCATT	0.368000													15	51					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12861601	12861601	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:12861601G>A	ENST00000456430.2	+	11	3002	c.2961G>A	c.(2959-2961)cgG>cgA	p.R987R	CAND2_ENST00000295989.5_Silent_p.R894R	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	987					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CACACACCCGGAGCACCGTCA	0.597000													22	75					0	0	1	0	0
CCDC176	80127	broad.mit.edu	37	14	74522295	74522295	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr14:74522295T>C	ENST00000394009.3	+	9	1418	c.1295T>C	c.(1294-1296)aTt>aCt	p.I432T	CCDC176_ENST00000553773.1_Missense_Mutation_p.I157T|CCDC176_ENST00000492247.2_5'UTR|AC005484.5_ENST00000492026.1_RNA	NM_025057.2	NP_079333.2			coiled-coil domain containing 176																		AGGACACATATTGAAGGAAAT	0.333000													11	67					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39156139	39156139	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:39156139G>A	ENST00000301819.6	+	6	799	c.622G>A	c.(622-624)Gtg>Atg	p.V208M	TTC21A_ENST00000431162.2_Missense_Mutation_p.V208M|TTC21A_ENST00000440121.1_Missense_Mutation_p.V167M	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	208							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CCAGATCACTGTGACTTCAGG	0.557000													53	93					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003928	122003928	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:122003928G>A	ENST00000498619.1	+	7	3595	c.3157G>A	c.(3157-3159)Gag>Aag	p.E1053K	CASR_ENST00000490131.1_Missense_Mutation_p.E1043K|CASR_ENST00000296154.5_Missense_Mutation_p.E1043K	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	1043					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCAGCGGCCAGAGGTGGAGGA	0.557000													17	127					0	0	1	0	0
MRPL50	54534	broad.mit.edu	37	9	104152981	104152981	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr9:104152981G>C	ENST00000374865.4	-	2	265	c.244C>G	c.(244-246)Ctt>Gtt	p.L82V	MRPL50_ENST00000539624.1_Missense_Mutation_p.L82V	NM_019051.2	NP_061924.1	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	82						mitochondrion|ribosome				large_intestine(1)|lung(2)|prostate(2)	5		Acute lymphoblastic leukemia(62;0.0559)				TTACTAGGAAGAGATGAACCA	0.433000													17	86					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127873057	127873057	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr5:127873057C>T	ENST00000508053.1	-	7	1214	c.240G>A	c.(238-240)caG>caA	p.Q80Q	FBN2_ENST00000508989.1_Silent_p.Q80Q|FBN2_ENST00000262464.4_Silent_p.Q80Q			P35556	FBN2_HUMAN	fibrillin 2	80					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGAGCACGTCCTGCTGTCCTC	0.682000													6	14					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65390540	65390540	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chrX:65390540G>A	ENST00000519389.1	+	2	469	c.290G>A	c.(289-291)gGa>gAa	p.G97E	HEPH_ENST00000419594.1_Missense_Mutation_p.G46E|HEPH_ENST00000336279.5_Intron|HEPH_ENST00000441993.2_Missense_Mutation_p.G46E|HEPH_ENST00000374727.3_Missense_Mutation_p.G46E|HEPH_ENST00000343002.2_Missense_Mutation_p.G43E			Q9BQS7	HEPH_HUMAN	hephaestin	43	Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GCTCCCAAGGGAAGAAATGTC	0.502000													11	19					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113591057	113591057	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:113591057C>T	ENST00000263341.2	-	4	405	c.195G>A	c.(193-195)gcG>gcA	p.A65A	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	65					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	CAACAACTGACGCGGCCTGCC	0.582000													28	143					0	0	1	0	0
PCMTD2	55251	broad.mit.edu	37	20	62891516	62891516	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr20:62891516G>A	ENST00000308824.6	+	2	325	c.198G>A	c.(196-198)ccG>ccA	p.P66P	PCMTD2_ENST00000369758.3_Silent_p.P66P|PCMTD2_ENST00000299468.7_Silent_p.P66P	NM_018257.2	NP_060727.2	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	66						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(9)|upper_aerodigestive_tract(1)	17	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TCTCAGCCCCGTGCATCTACT	0.493000													77	81					0	0	1	0	0
C10orf11	83938	broad.mit.edu	37	10	77807015	77807015	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr10:77807015G>A	ENST00000372499.1	+	3	483	c.268G>A	c.(268-270)Gag>Aag	p.E90K	C10orf11_ENST00000593699.1_3'UTR	NM_032024.3	NP_114413.1	Q9H2I8	CJ011_HUMAN	chromosome 10 open reading frame 11	90										endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	10	Prostate(51;0.0095)|all_epithelial(25;0.0221)					CTGTCCCAACGAGCTGGTCAG	0.507000													4	61					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60913316	60913316	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr20:60913316G>A	ENST00000252999.3	-	13	1794	c.1728C>T	c.(1726-1728)ccC>ccT	p.P576P		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	576	Laminin EGF-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAAGTAGCCGGGGGCACAGC	0.672000													5	18					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703134	55703134	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:55703134G>T	ENST00000301532.3	-	1	742	c.743C>A	c.(742-744)aCt>aAt	p.T248N		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						CGTCACTGAAGTCAGGTGAGA	0.433000													4	33					0.00909568	0.00922085	1	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103070182	103070182	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:103070182C>T	ENST00000375735.2	+	49	8209	c.8065C>T	c.(8065-8067)Cag>Tag	p.Q2689*	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Nonsense_Mutation_p.Q2689*	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2689	AAA 4 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGAACTGAAGCAGTTCAAAAA	0.393000													3	15					0	0	1	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82366922	82366922	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr4:82366922T>C	ENST00000509081.1	-	7	1018	c.797A>G	c.(796-798)tAc>tGc	p.Y266C	RASGEF1B_ENST00000264400.2_Missense_Mutation_p.Y267C|RASGEF1B_ENST00000335927.7_Missense_Mutation_p.Y225C			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	267	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						AGCAACCAAGTAGCTGAGGCG	0.368000													10	44					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617976	77617976	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr8:77617976C>G	ENST00000521891.2	+	2	2101	c.1653C>G	c.(1651-1653)aaC>aaG	p.N551K	ZFHX4_ENST00000518282.1_Missense_Mutation_p.N551K|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.N551K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.N551K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	551						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTGCTAGTAACTATGGCATCA	0.502000										HNSCC(33;0.089)			27	33					0	0	1	0	0
THAP7	80764	broad.mit.edu	37	22	21355551	21355551	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr22:21355551C>T	ENST00000215742.4	-	2	404	c.230G>A	c.(229-231)gGa>gAa	p.G77E	THAP7_ENST00000399133.2_Missense_Mutation_p.G77E	NM_030573.2	NP_085050.2	Q9BT49	THAP7_HUMAN	THAP domain containing 7	77					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding			cervix(1)|lung(2)|prostate(3)|skin(1)|stomach(1)	8	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CCACCTGATTCCCACCAGCTC	0.652000													44	555					0	0	1	0	0
EAF2	55840	broad.mit.edu	37	3	121554181	121554181	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:121554181C>G	ENST00000273668.2	+	1	120	c.49C>G	c.(49-51)Ctc>Gtc	p.L17V	EAF2_ENST00000451944.2_Missense_Mutation_p.L17V|EAF2_ENST00000465664.1_3'UTR	NM_018456.4	NP_060926.2	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	17	Necessary for interaction with ELL.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)	9				GBM - Glioblastoma multiforme(114;0.0972)		CGAGCGGGTTCTCAAGTTAGG	0.587000													10	86					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61654293	61654293	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr8:61654293C>T	ENST00000423902.2	+	2	781	c.302C>T	c.(301-303)cCg>cTg	p.P101L	CHD7_ENST00000525508.1_Missense_Mutation_p.P101L|CHD7_ENST00000524602.1_Missense_Mutation_p.P101L	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	101					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTCGCGTCTCCGCACTCGCAG	0.532000													11	35					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55138567	55138567	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr4:55138567C>T	ENST00000257290.5	+	9	1575	c.1244C>T	c.(1243-1245)tCa>tTa	p.S415L	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	415	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GCAGTTCCTTCATCCATTCTG	0.483000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			9	122					0	0	1	0	0
ST3GAL6	10402	broad.mit.edu	37	3	98507004	98507004	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:98507004C>T	ENST00000265261.6	+	7	624	c.202C>T	c.(202-204)Ctc>Ttc	p.L68F	ST3GAL6_ENST00000394162.1_Missense_Mutation_p.L186F|ST3GAL6_ENST00000483910.1_Missense_Mutation_p.L186F|ST3GAL6_ENST00000462152.1_3'UTR	NM_001271147.1	NP_001258076.1	Q9Y274	SIA10_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	186					amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(1)	19						GACAGTGATTCTCACTGCTTT	0.383000													12	36					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:7578263G>A	ENST00000420246.2	-	6	718	c.586C>T	c.(586-588)Cga>Tga	p.R196*	TP53_ENST00000269305.4_Nonsense_Mutation_p.R196*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R196*|TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Nonsense_Mutation_p.R196*|TP53_ENST00000445888.2_Nonsense_Mutation_p.R196*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R196*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	196	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(167)|p.R64*(14)|p.R103*(14)|p.0?(8)|p.R196fs*51(7)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.R196R(2)|p.I195fs*50(1)|p.R64fs*>27(1)|p.R103fs*51(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.I195fs*12(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	41					0	0	1	0	0
PAQR6	79957	broad.mit.edu	37	1	156213684	156213684	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:156213684G>C	ENST00000335852.1	-	7	1639	c.1024C>G	c.(1024-1026)Ctg>Gtg	p.L342V	PAQR6_ENST00000368270.1_3'UTR|PAQR6_ENST00000292291.5_3'UTR|PAQR6_ENST00000492619.1_5'UTR|PAQR6_ENST00000356983.2_Missense_Mutation_p.L342V|PAQR6_ENST00000360733.2_Missense_Mutation_p.L342V	NM_024897.2	NP_079173.2	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	0						integral to membrane	receptor activity			lung(4)|ovary(1)	5	Hepatocellular(266;0.158)					TCCCCTCTCAGACCCTCAGCA	0.587000													97	492					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47570716	47570716	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:47570716C>T	ENST00000253048.5	-	15	2846	c.2809G>A	c.(2809-2811)Gtg>Atg	p.V937M	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	937							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGAATGTTCACGGCCTTCTCC	0.667000													50	174					0	0	1	0	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727227	25727227	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:25727227C>T	ENST00000274764.2	+	1	91	c.91C>T	c.(91-93)Cgc>Tgc	p.R31C		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	31					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						AGGCAAAAAGCGCAAGAGGAC	0.448000													19	91					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139944405	139944405	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr9:139944405G>A	ENST00000355097.2	-	7	1113	c.1066C>T	c.(1066-1068)Cgg>Tgg	p.R356W	ENTPD2_ENST00000312665.5_Missense_Mutation_p.R356W	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	356						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ATCGAAGTCCGCAAAAAGTCC	0.647000											OREG0019627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	110					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123434446	123434446	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:123434446G>A	ENST00000542678.1	-	4	3574	c.736C>T	c.(736-738)Cgg>Tgg	p.R246W	ABCB9_ENST00000540285.1_Missense_Mutation_p.R246W|ABCB9_ENST00000280560.8_Missense_Mutation_p.R246W|ABCB9_ENST00000442028.2_Missense_Mutation_p.R246W|ABCB9_ENST00000344275.7_Missense_Mutation_p.R246W|ABCB9_ENST00000442833.2_Missense_Mutation_p.R246W|ABCB9_ENST00000346530.5_Missense_Mutation_p.R246W|ABCB9_ENST00000392439.3_Missense_Mutation_p.R246W			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	246	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding	p.R246W(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		ATGCCGCCCCGAATACCTGCG	0.527000													4	184					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751914	247751914	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:247751914C>A	ENST00000320065.1	+	1	253	c.253C>A	c.(253-255)Ctg>Atg	p.L85M	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCCCCAGCTCCTGGTAAACCT	0.512000													10	171					4.68919e-08	5.13025e-08	1	1	0
EHBP1L1	254102	broad.mit.edu	37	11	65347886	65347886	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65347886G>A	ENST00000309295.4	+	6	835	c.570G>A	c.(568-570)gaG>gaA	p.E190E		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	190										central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						ACTTTGCTGAGAGTGATGAAG	0.592000													20	77					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72296444	72296444	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:72296444C>T	ENST00000334456.5	-	16	1502	c.1257G>A	c.(1255-1257)acG>acA	p.T419T	PDE2A_ENST00000444035.2_Silent_p.T410T|PDE2A_ENST00000418754.2_Silent_p.T304T|PDE2A_ENST00000376450.3_Silent_p.T163T|PDE2A_ENST00000540345.1_Silent_p.T410T|RP11-169D4.2_ENST00000545254.1_RNA|PDE2A_ENST00000544570.1_Silent_p.T412T	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	419	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	TTCTGGCCTCCGTGATGATCT	0.602000											OREG0021196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	84					0	0	1	0	0
HSPA6	3310	broad.mit.edu	37	1	161495172	161495172	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:161495172C>T	ENST00000309758.4	+	1	1137	c.724C>T	c.(724-726)Cac>Tac	p.H242Y		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	242					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCTCGTGAACCACTTCATGGA	0.602000													13	33					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3188826	3188826	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr18:3188826G>C	ENST00000356443.4	-	4	1024	c.691C>G	c.(691-693)Caa>Gaa	p.Q231E	MYOM1_ENST00000400569.3_Missense_Mutation_p.Q231E|MYOM1_ENST00000261606.7_Missense_Mutation_p.Q231E	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	231						striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TCTTCCTGTTGAAGAGCGGAT	0.493000													20	48					0	0	1	0	0
KLRC3	3823	broad.mit.edu	37	12	10572189	10572189	+	Missense_Mutation	SNP	A	A	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:10572189A>C	ENST00000381904.2	-	3	289	c.290T>G	c.(289-291)cTg>cGg	p.L97R	KLRC3_ENST00000396439.2_Intron|KLRC3_ENST00000381903.2_Intron|NKG2-E_ENST00000539033.1_Intron					killer cell lectin-like receptor subfamily C, member 3											large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						GTTCTGCTCCAGGACTGTAAT	0.254000													5	37					0	0	1	0	0
SDHAP1	255812	broad.mit.edu	37	3	195711466	195711466	+	RNA	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:195711466G>T	ENST00000427841.1	-	0	481					NR_003264.2																						GCCCATCACCGCGACCATGGC	0.582000													4	59					0.00116845	0.00119549	1	1	0
SLC34A3	142680	broad.mit.edu	37	9	140128975	140128975	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr9:140128975C>T	ENST00000538474.1	+	11	1425	c.1201C>T	c.(1201-1203)Ccc>Tcc	p.P401S	SLC34A3_ENST00000361134.2_Missense_Mutation_p.P401S	NM_001177316.1|NM_001177317.1	NP_001170787.1|NP_001170788.1	Q8N130	NPT2C_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 3	401					cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			kidney(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGCCGTCGTGCCCCTCATGGG	0.716000													18	31					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14304622	14304622	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr5:14304622C>T	ENST00000344204.4	+	8	1445	c.1421C>T	c.(1420-1422)cCc>cTc	p.P474L	TRIO_ENST00000537187.1_Missense_Mutation_p.P474L|TRIO_ENST00000509967.2_Missense_Mutation_p.P425L	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	474					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GTAGACCTTCCCTCAGAGCTG	0.393000													24	96					0	0	1	0	0
MT1L	4500	broad.mit.edu	37	16	56652578	56652578	+	RNA	SNP	A	A	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr16:56652578A>G	ENST00000565768.1	+	0	259					NR_001447.2				metallothionein 1L (gene/pseudogene)																		GGAGAAGTGCAGCTGCTGTGC	0.567000													4	192					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32088217	32088217	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr5:32088217G>A	ENST00000438447.1	+	20	5051	c.4663G>A	c.(4663-4665)Gct>Act	p.A1555T	PDZD2_ENST00000282493.3_Missense_Mutation_p.A1555T			O15018	PDZD2_HUMAN	PDZ domain containing 2	1555					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GTATGGCGATGCTGAGGATTC	0.537000													27	75					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153697014	153697014	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chrX:153697014C>T	ENST00000369682.3	+	24	4404	c.4229C>T	c.(4228-4230)tCa>tTa	p.S1410L		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1410					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGACAGAGTCAGTGGCTGAG	0.627000													12	48					0	0	1	0	0
NAGA	4668	broad.mit.edu	37	22	42457071	42457071	+	Splice_Site	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr22:42457071C>T	ENST00000396398.3	-	8	1490	c.957_splice	c.e8-1	p.E320_splice	NAGA_ENST00000402937.1_Splice_Site_p.E320_splice|NAGA_ENST00000403363.1_Splice_Site_p.E320_splice	NM_000262.2	NP_000253.1	P17050	NAGAB_HUMAN	N-acetylgalactosaminidase, alpha-	320					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						AGAGATTTTTCCTGGGCACAG	0.567000													11	37					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920199	4920199	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:4920199A>G	ENST00000433855.1	+	1	1858	c.992A>G	c.(991-993)aAt>aGt	p.N331S	KCNA6_ENST00000280684.3_Missense_Mutation_p.N331S	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	331						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GGCGGCCAGAATGGGCAGCAG	0.617000										HNSCC(72;0.22)			15	71					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304740	102304740	+	RNA	SNP	G	G	A	rs7169420	by1000genomes	TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr15:102304740G>A	ENST00000561463.1	+	0	12786																											GAAGACACTCGTGGAGGAGTC	0.612000													3	19					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753377	76753377	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr18:76753377C>T	ENST00000536229.3	+	1	1696	c.987C>T	c.(985-987)aaC>aaT	p.N329N	SALL3_ENST00000575389.2_Silent_p.N462N|SALL3_ENST00000537592.2_Silent_p.N462N			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCAAAGGCAACCTGAAGGTGC	0.622000													8	26					0	0	1	0	0
STRA8	346673	broad.mit.edu	37	7	134927560	134927560	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:134927560C>T	ENST00000275764.3	+	3	286	c.286C>T	c.(286-288)Cat>Tat	p.H96Y		NM_182489.1	NP_872295.1	Q7Z7C7	STRA8_HUMAN	stimulated by retinoic acid 8	96					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus		p.H96N(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(1)	16						GGCAAAGAGTCATATTCCAGA	0.483000													24	85					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349278	65349278	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65349278G>A	ENST00000309295.4	+	9	1400	c.1135G>A	c.(1135-1137)Gaa>Aaa	p.E379K		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	379										central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						ACTCAAGGCTGAAGAGATGGA	0.572000													11	29					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51013227	51013227	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr18:51013227C>T	ENST00000442544.2	+	26	4413	c.3797C>T	c.(3796-3798)cCg>cTg	p.P1266L	DCC_ENST00000581580.1_Missense_Mutation_p.P901L|RP11-671P2.1_ENST00000582064.1_RNA	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1266					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GGAATCCTCCCGTCTCCCACC	0.547000													32	108					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675076	81675076	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:81675076C>A	ENST00000550584.2	-	26	3467	c.3172G>T	c.(3172-3174)Gat>Tat	p.D1058Y	PPFIA2_ENST00000541570.2_Missense_Mutation_p.D594Y|PPFIA2_ENST00000548586.1_Missense_Mutation_p.D1052Y|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000407050.4_Missense_Mutation_p.D957Y|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000443686.3_Missense_Mutation_p.D953Y|PPFIA2_ENST00000552948.1_Missense_Mutation_p.D1037Y|PPFIA2_ENST00000549325.1_Missense_Mutation_p.D1043Y|PPFIA2_ENST00000541017.1_Missense_Mutation_p.D244Y|PPFIA2_ENST00000333447.7_Missense_Mutation_p.D1043Y|PPFIA2_ENST00000550359.2_Missense_Mutation_p.D905Y|PPFIA2_ENST00000549396.1_Missense_Mutation_p.D1058Y	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	957										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ACACGGAGATCTTTTTTTGTT	0.348000													4	32					0.00024832	0.00025525	1	1	0
MYO1E	4643	broad.mit.edu	37	15	59494582	59494582	+	Silent	SNP	C	C	T	rs142116200	byFrequency	TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr15:59494582C>T	ENST00000288235.4	-	16	2040	c.1641G>A	c.(1639-1641)ccG>ccA	p.P547P		NM_004998.3	NP_004989.2	Q12965	MYO1E_HUMAN	myosin IE	547	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(6)|lung(10)|pancreas(2)|prostate(1)|urinary_tract(1)	33				all cancers(107;0.207)		GCAGATTTTCCGGAAATAAAG	0.408000													4	98					0	0	1	0	0
KCNK4	50801	broad.mit.edu	37	11	64067045	64067045	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:64067045C>T	ENST00000538767.1	+	6	934	c.682C>T	c.(682-684)Cct>Tct	p.P228S	KCNK4_ENST00000539216.1_Silent_p.N343N|KCNK4_ENST00000422670.2_Silent_p.N343N|KCNK4_ENST00000394525.2_Silent_p.N343N|RP11-783K16.10_ENST00000539086.1_RNA			Q9NYG8	KCNK4_HUMAN	potassium channel, subfamily K, member 4	323						integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(2)|large_intestine(2)|lung(3)|prostate(2)|urinary_tract(1)	10						CCAGCGAGAACCTGGCCTTCA	0.731000													26	93					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10533201	10533201	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:10533201C>T	ENST00000583535.1	-	39	5703	c.5616G>A	c.(5614-5616)ctG>ctA	p.L1872L	MYH3_ENST00000226209.7_Silent_p.L1872L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1872					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CTTTCACTTGCAGTTTATCCA	0.517000													70	91					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201061191	201061191	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:201061191G>A	ENST00000362061.3	-	4	676	c.450C>T	c.(448-450)gcC>gcT	p.A150A	CACNA1S_ENST00000367338.3_Silent_p.A150A	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	150					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGCTCATTGGGGCTGTGTGGC	0.597000													37	82					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													3	39					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105577362	105577362	+	Silent	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:105577362G>T	ENST00000314641.5	-	3	459	c.243C>A	c.(241-243)atC>atA	p.I81I	BVES_ENST00000336775.5_Silent_p.I81I|BVES_ENST00000446408.2_Silent_p.I81I	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	81					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TGGCCCAGACGATATAAAGGG	0.383000													22	94					9.57634e-11	1.0635e-10	1	1	0
NDUFA7	4701	broad.mit.edu	37	19	8385742	8385742	+	Splice_Site	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:8385742G>A	ENST00000301457.2	-	2	137	c.101_splice	c.e2+1	p.R34_splice	NDUFA7_ENST00000598884.1_Splice_Site_p.R34_splice	NM_005001.3	NP_004992.2	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	34					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			NS(1)|central_nervous_system(1)|lung(2)|ovary(1)	5					NADH(DB00157)	CCTGCTCACCGCTTGGAGATC	0.602000													6	267					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52788815	52788815	+	Missense_Mutation	SNP	G	G	A	rs139996519		TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:52788815G>A	ENST00000257974.2	-	9	1563	c.1486C>T	c.(1486-1488)Cgg>Tgg	p.R496W	RP3-416H24.4_ENST00000547174.1_RNA	NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	496	Tail.					keratin filament	protein binding|structural constituent of epidermis	p.R496W(1)		endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		CTGGATTTCCGCCCGCTCCCA	0.642000													26	69					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57293445	57293445	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:57293445C>T	ENST00000391708.3	-	10	1064	c.522G>A	c.(520-522)gaG>gaA	p.E174E	ZIM2_ENST00000593711.1_Silent_p.E174E|ZIM2_ENST00000599935.1_Silent_p.E174E|ZIM2_ENST00000221722.5_Silent_p.E174E|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000594400.1_RNA|AC006115.3_ENST00000595954.1_RNA|ZIM2_ENST00000601070.1_Silent_p.E174E	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		AGGTCACCAACTCCTCAAACA	0.502000													31	128					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735497	55735497	+	Missense_Mutation	SNP	A	A	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:55735497A>C	ENST00000312345.2	-	1	493	c.443T>G	c.(442-444)aTt>aGt	p.I148S		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					TGTTTCCCCAATTACTACAGG	0.413000													16	70					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38424475	38424475	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:38424475C>G	ENST00000356264.2	-	21	2247	c.2032G>C	c.(2032-2034)Gac>Cac	p.D678H	AMPH_ENST00000325590.5_Missense_Mutation_p.D636H|AMPH_ENST00000428293.2_Missense_Mutation_p.D636H	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	678	SH3.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane		p.D678H(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						GTGGCAAGGTCTCTGTACTGA	0.478000													22	106					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36978761	36978761	+	Missense_Mutation	SNP	A	A	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:36978761A>C	ENST00000274963.8	+	3	484	c.313A>C	c.(313-315)Aag>Cag	p.K105Q		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	105	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						GCCAGAGAAGAAGATCGTCCA	0.602000													16	72					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42582950	42582950	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:42582950G>A	ENST00000600245.1	+	2	847	c.192G>A	c.(190-192)acG>acA	p.T64T	CTB-59C6.3_ENST00000594531.1_RNA|ZNF574_ENST00000222339.7_Silent_p.T154T|ZNF574_ENST00000359044.4_Silent_p.T64T			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				CTTCAGGCACGGGCCTCTATC	0.607000													7	99					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53722976	53722976	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:53722976G>A	ENST00000306052.6	-	15	2471	c.2370C>T	c.(2368-2370)gtC>gtT	p.V790V	LRP8_ENST00000465675.1_Silent_p.V343V|LRP8_ENST00000371454.2_Silent_p.V790V|LRP8_ENST00000354412.3_Intron|LRP8_ENST00000347547.2_Silent_p.V620V|LRP8_ENST00000460214.1_5'UTR	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	790	Clustered O-linked oligosaccharides.				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						GAGCCCTGGGGACACTAACTG	0.572000													4	63					0	0	1	0	0
TPRKB	51002	broad.mit.edu	37	2	73961564	73961564	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:73961564G>A	ENST00000318190.7	-	2	253	c.133C>T	c.(133-135)Cct>Tct	p.P45S	TPRKB_ENST00000272424.5_Missense_Mutation_p.P45S|TPRKB_ENST00000409716.2_Missense_Mutation_p.P45S			Q9Y3C4	TPRKB_HUMAN	TP53RK binding protein	45					protein catabolic process	cytosol|nucleus	protein kinase binding			lung(2)|ovary(1)|skin(1)	4						ACCACTGTAGGATTTATCAGT	0.468000													32	57					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179642012	179642012	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:179642012C>T	ENST00000589042.1	-	27	4902	c.4678G>A	c.(4678-4680)Gaa>Aaa	p.E1560K	TTN_ENST00000460472.2_Missense_Mutation_p.E1514K|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E1514K|TTN_ENST00000342992.6_Missense_Mutation_p.E1560K|TTN_ENST00000591111.1_Missense_Mutation_p.E1560K|TTN_ENST00000360870.5_Missense_Mutation_p.E1560K|TTN_ENST00000342175.6_Missense_Mutation_p.E1514K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1295	Ig-like 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGTTTTTCTACAAACATC	0.393000													11	43					0	0	1	0	0
SOCS1	8651	broad.mit.edu	37	16	11349065	11349065	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr16:11349065C>T	ENST00000332029.2	-	2	421	c.271G>A	c.(271-273)Gag>Aag	p.E91K	RMI2_ENST00000572173.1_Intron	NM_003745.1	NP_003736.1	O15524	SOCS1_HUMAN	suppressor of cytokine signaling 1	91	SH2.				interferon-gamma-mediated signaling pathway|JAK-STAT cascade|negative regulation of insulin receptor signaling pathway|negative regulation of tyrosine phosphorylation of Stat3 protein|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	insulin-like growth factor receptor binding|protein kinase binding|protein kinase inhibitor activity	p.Y64fs*1(1)|p.0?(1)|p.D63_Q108del(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(66)|lung(3)	71						CGCAGCCGCTCGTGCGCCCCG	0.701000			"""F, O"""		"""Hodgkin Lymphoma, PMBL"""								3	14					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207527900	207527900	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:207527900C>G	ENST00000452335.2	-	11	1476	c.1360G>C	c.(1360-1362)Gaa>Caa	p.E454Q		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	454						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TCTGGTGATTCTGGATTTCGC	0.483000													22	39					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30691832	30691832	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:30691832A>G	ENST00000295754.5	+	3	716	c.334A>G	c.(334-336)Att>Gtt	p.I112V	TGFBR2_ENST00000359013.4_Missense_Mutation_p.I137V	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	112					activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						CCATGACTTTATTCTGGAAGA	0.433000													40	70					0	0	1	0	0
GDPD2	54857	broad.mit.edu	37	X	69649407	69649407	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chrX:69649407C>T	ENST00000453994.2	+	11	1362	c.1001C>T	c.(1000-1002)aCg>aTg	p.T334M	GDPD2_ENST00000538649.1_Missense_Mutation_p.T255M|GDPD2_ENST00000536730.1_Missense_Mutation_p.T255M|GDPD2_ENST00000374382.3_Missense_Mutation_p.T334M|GDPD2_ENST00000472623.1_3'UTR	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	334	GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					GAGAGTCAGACGGTACCAGCA	0.517000													3	41					0	0	1	0	0
PRMT3	10196	broad.mit.edu	37	11	20448356	20448356	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:20448356T>C	ENST00000331079.6	+	10	1155	c.938T>C	c.(937-939)aTt>aCt	p.I313T	PRMT3_ENST00000437750.2_Missense_Mutation_p.I251T	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	313							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						AAAGGAAAGATTGAAGAAGTT	0.274000													6	15					0	0	1	0	0
CES4A	283848	broad.mit.edu	37	16	67043004	67043004	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr16:67043004C>G	ENST00000326686.5	+	14	1645	c.1645C>G	c.(1645-1647)Ctg>Gtg	p.L549V	CES4A_ENST00000398354.1_Missense_Mutation_p.L479V|CES4A_ENST00000535696.1_3'UTR|CES4A_ENST00000540947.2_3'UTR|CES4A_ENST00000540579.1_Missense_Mutation_p.L451V|CES4A_ENST00000541479.1_Missense_Mutation_p.L502V|CES4A_ENST00000338718.4_3'UTR|CES4A_ENST00000397205.2_3'UTR			Q5XG92	EST4A_HUMAN	carboxylesterase 4A	549						extracellular region	carboxylesterase activity			large_intestine(2)|liver(2)|lung(4)|ovary(1)	9						TTGGATGAGTCTGTACCAGTC	0.522000													20	191					0	0	1	0	0
SMPD4P1	645280	broad.mit.edu	37	22	20970528	20970528	+	RNA	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr22:20970528G>A	ENST00000443839.1	-	0	2096																											CTGGGACTCTGACCCATATAG	0.488000													9	21					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005051	74005051	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:74005051A>T	ENST00000301607.3	-	22	4488	c.4235T>A	c.(4234-4236)cTg>cAg	p.L1412Q	EVPL_ENST00000586740.1_Missense_Mutation_p.L1434Q	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1412	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCCGGCCCGCAGCTGCTGCAC	0.697000													47	76					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9792806	9792806	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:9792806G>A	ENST00000262441.5	+	13	1959	c.1446G>A	c.(1444-1446)tcG>tcA	p.S482S	GLP2R_ENST00000574745.1_Silent_p.S302S	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	482					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	AGAAGCTCTCGGAAGGAGATG	0.597000													34	79					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53754794	53754794	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:53754794A>G	ENST00000333952.4	-	3	175	c.10T>C	c.(10-12)Tct>Cct	p.S4P	ZNF677_ENST00000598513.1_Missense_Mutation_p.S4P|ZNF677_ENST00000598806.1_Missense_Mutation_p.S4P|ZNF677_ENST00000594681.1_Missense_Mutation_p.S4P|ZNF677_ENST00000599012.1_Missense_Mutation_p.S4P|ZNF677_ENST00000601413.1_Missense_Mutation_p.S4P|ZNF677_ENST00000601828.1_Missense_Mutation_p.S4P|ZNF677_ENST00000595293.1_5'UTR			Q86XU0	ZN677_HUMAN	zinc finger protein 677	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TTTACCTGAGAAAGAGCCATT	0.368000													7	39					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65350465	65350465	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65350465G>A	ENST00000309295.4	+	9	2587	c.2322G>A	c.(2320-2322)ttG>ttA	p.L774L		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	774	Glu-rich.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						GTGCGATATTGGGGACCCAAG	0.527000													10	44					0	0	1	0	0
QKI	9444	broad.mit.edu	37	6	163984721	163984721	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:163984721G>C	ENST00000361752.3	+	6	1455	c.904G>C	c.(904-906)Gag>Cag	p.E302Q	QKI_ENST00000392127.2_Missense_Mutation_p.E302Q|QKI_ENST00000453779.2_Missense_Mutation_p.E302Q|QKI_ENST00000424802.3_Missense_Mutation_p.E294Q|QKI_ENST00000275262.7_Missense_Mutation_p.E302Q|QKI_ENST00000361195.2_Missense_Mutation_p.E294Q	NM_006775.2|NM_206853.2|NM_206854.2|NM_206855.2	NP_006766.1|NP_996735.1|NP_996736.1|NP_996737.1	Q96PU8	QKI_HUMAN	QKI, KH domain containing, RNA binding	302					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(5)|ovary(1)|prostate(3)|urinary_tract(2)	27		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		ATCAATCCTTGAGTATCCTAT	0.423000													28	83					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162865097	162865097	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:162865097C>T	ENST00000360534.3	-	22	2522	c.1962G>A	c.(1960-1962)gcG>gcA	p.A654A	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	654					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	GGGATACAGGCGCCACGGCTA	0.468000													19	74					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151962255	151962255	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:151962255C>T	ENST00000355193.2	-	8	1270	c.1052G>A	c.(1051-1053)gGa>gAa	p.G351E	KMT2C_ENST00000262189.6_Missense_Mutation_p.G351E					lysine (K)-specific methyltransferase 2C																		TAAGAGGTCTCCCGGGCTGTC	0.393000													19	218					0	0	1	0	0
YRDC	79693	broad.mit.edu	37	1	38269639	38269639	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:38269639T>A	ENST00000373044.2	-	5	802	c.798A>T	c.(796-798)caA>caT	p.Q266H		NM_024640.3	NP_078916.3	Q86U90	YRDC_HUMAN	yrdC N(6)-threonylcarbamoyltransferase domain containing	266					negative regulation of transport	membrane|mitochondrion				lung(2)|upper_aerodigestive_tract(1)	3	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CGTACTTCTGTTGGAGGATGG	0.552000													17	45					0	0	1	0	0
CEP68	23177	broad.mit.edu	37	2	65301482	65301482	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:65301482G>A	ENST00000377990.2	+	4	2154	c.1951G>A	c.(1951-1953)Ggg>Agg	p.G651R	CEP68_ENST00000260569.4_Missense_Mutation_p.G514R|CEP68_ENST00000546106.1_Missense_Mutation_p.G651R|RAB1A_ENST00000494188.1_Intron|CEP68_ENST00000497039.1_3'UTR|CEP68_ENST00000537589.1_3'UTR	NM_015147.2	NP_055962.2	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	651					centrosome organization	centrosome				breast(1)|endometrium(6)|kidney(8)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32						TACTGACCACGGGACTGCAGC	0.483000													4	81					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101759890	101759890	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr13:101759890C>G	ENST00000251127.6	-	22	2608	c.2527G>C	c.(2527-2529)Gaa>Caa	p.E843Q		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	843						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AACCTGTGTTCTCGCCCGACA	0.498000													13	91					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50742257	50742257	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:50742257G>A	ENST00000403097.1	-	5	1000	c.220C>T	c.(220-222)Ctg>Ttg	p.L74L	GRB10_ENST00000407526.1_Silent_p.L22L|GRB10_ENST00000335866.3_Silent_p.L22L|GRB10_ENST00000357271.5_Silent_p.L80L|GRB10_ENST00000406641.1_Silent_p.L22L|GRB10_ENST00000402497.1_Silent_p.L22L|GRB10_ENST00000402578.1_Silent_p.L22L|GRB10_ENST00000401949.1_Silent_p.L80L|GRB10_ENST00000439599.1_Silent_p.L74L|GRB10_ENST00000398812.2_Silent_p.L80L|GRB10_ENST00000398810.2_Silent_p.L22L			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	80					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CCATTCTGCAGGAGGGGCACC	0.637000									Russell-Silver syndrome				17	61					0	0	1	0	0
NCDN	23154	broad.mit.edu	37	1	36030832	36030832	+	Silent	SNP	T	T	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:36030832T>G	ENST00000373243.2	+	7	2141	c.1758T>G	c.(1756-1758)ctT>ctG	p.L586L	NCDN_ENST00000373253.3_Silent_p.L569L|NCDN_ENST00000356090.4_Silent_p.L586L	NM_014284.2	NP_055099.1	Q9UBB6	NCDN_HUMAN	neurochondrin	586					neuron projection development	cytosol|dendrite|neuronal cell body				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|pancreas(1)|skin(2)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTGCAGCTCTTCAGGGAACAC	0.612000											OREG0013355	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	132					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155266	22155266	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:22155266C>A	ENST00000397126.4	-	4	2718	c.2570G>T	c.(2569-2571)gGa>gTa	p.G857V	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGGTTTCTCTCCAGTATGAAT	0.373000													6	58					8.12818e-05	8.39406e-05	1	1	0
TATDN2	9797	broad.mit.edu	37	3	10290992	10290992	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:10290992C>G	ENST00000287652.4	+	2	1159	c.108C>G	c.(106-108)agC>agG	p.S36R	TATDN2_ENST00000448281.2_Missense_Mutation_p.S36R	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	36						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						CCCCCTCCAGCCGGCCAGCTC	0.672000													8	120					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75682073	75682073	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr15:75682073C>G	ENST00000394947.3	-	16	3255	c.2941G>C	c.(2941-2943)Gat>Cat	p.D981H	SIN3A_ENST00000360439.4_Missense_Mutation_p.D981H|SIN3A_ENST00000394949.4_Missense_Mutation_p.D981H	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	981					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						CTCAGTGAATCTTCATACTGT	0.483000													43	92					0	0	1	0	0
ACOT4	122970	broad.mit.edu	37	14	74062114	74062114	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr14:74062114G>A	ENST00000326303.4	+	3	1276	c.1022G>A	c.(1021-1023)cGg>cAg	p.R341Q		NM_152331.3	NP_689544.3	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	341					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(234;0.00331)		GTCTCTGAACGGTTACAGGCC	0.517000													14	60					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38040429	38040429	+	Silent	SNP	G	G	A	rs35699577		TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr3:38040429G>A	ENST00000283713.6	+	10	1235	c.969G>A	c.(967-969)ccG>ccA	p.P323P	VILL_ENST00000383759.2_Silent_p.P323P|VILL_ENST00000465644.1_Silent_p.P41P			O15195	VILL_HUMAN	villin-like	323					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AGGGCTACCCGACCTACACCA	0.657000													8	28					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229893	8229893	+	Silent	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr4:8229893C>T	ENST00000539824.1	+	12	2618	c.2244C>T	c.(2242-2244)atC>atT	p.I748I	SH3TC1_ENST00000245105.3_Silent_p.I824I			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	824							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TCCGTGCCATCGTGGACCACC	0.662000													3	22					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7254578	7254578	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr12:7254578G>A	ENST00000266542.4	-	3	498	c.406C>T	c.(406-408)Cgg>Tgg	p.R136W	C1RL_ENST00000545337.1_Missense_Mutation_p.R136W|C1RL_ENST00000544702.1_Missense_Mutation_p.R136W|C1RL_ENST00000545280.1_Intron	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	136	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						AAGGTCAGCCGCAAACTCCTC	0.607000													6	216					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72296443	72296443	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:72296443C>T	ENST00000334456.5	-	16	1503	c.1258G>A	c.(1258-1260)Gag>Aag	p.E420K	PDE2A_ENST00000444035.2_Missense_Mutation_p.E411K|PDE2A_ENST00000418754.2_Missense_Mutation_p.E305K|PDE2A_ENST00000376450.3_Missense_Mutation_p.E164K|PDE2A_ENST00000540345.1_Missense_Mutation_p.E411K|RP11-169D4.2_ENST00000545254.1_RNA|PDE2A_ENST00000544570.1_Missense_Mutation_p.E413K	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	420	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	TTTCTGGCCTCCGTGATGATC	0.607000											OREG0021196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	84					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3189497	3189497	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr4:3189497G>A	ENST00000355072.5	+	39	5254	c.5109G>A	c.(5107-5109)ccG>ccA	p.P1703P		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1703					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCTTCTCTCCGTATTTAATCT	0.403000													4	97					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65350925	65350925	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65350925G>A	ENST00000309295.4	+	9	3047	c.2782G>A	c.(2782-2784)Gag>Aag	p.E928K		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	928										central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						ACAAGGGTCAGAGACTCAAGT	0.537000													11	28					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112029202	112029202	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:112029202G>A	ENST00000354650.3	-	6	972	c.366C>T	c.(364-366)gcC>gcT	p.A122A	FYN_ENST00000356013.2_Silent_p.A122A|FYN_ENST00000229470.5_Intron|FYN_ENST00000476769.2_5'UTR|FYN_ENST00000368682.3_Silent_p.A122A|FYN_ENST00000538466.1_Silent_p.A122A|FYN_ENST00000229471.4_Silent_p.A122A|FYN_ENST00000368667.2_Silent_p.A122A|FYN_ENST00000368678.4_Silent_p.A122A	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	122	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TCAAGGAGCGGGCTTCCCACC	0.418000													13	49					0	0	1	0	0
WNT9B	7484	broad.mit.edu	37	17	44950110	44950110	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:44950110T>C	ENST00000393461.2	+	2	358	c.305T>C	c.(304-306)cTg>cCg	p.L102P	WNT9B_ENST00000290015.2_Missense_Mutation_p.L102P			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	102					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AACTGTAGCCTGGAGGGCAGG	0.672000													7	31					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47296206	47296206	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr20:47296206C>G	ENST00000396220.1	-	12	1544	c.1522G>C	c.(1522-1524)Gag>Cag	p.E508Q	PREX1_ENST00000371941.3_Missense_Mutation_p.E508Q			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	508					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			ATGATGTCCTCCAGCTCACTT	0.592000													19	80					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41729352	41729352	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:41729352G>A	ENST00000242208.4	-	3	1423	c.1177C>T	c.(1177-1179)Ccc>Tcc	p.P393S	INHBA_ENST00000442711.1_Missense_Mutation_p.P393S|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000464515.1_5'UTR	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	393					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						AGCTTGGTGGGCACACAGCAC	0.522000										TSP Lung(11;0.080)			4	103					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404200	197404200	+	Silent	SNP	A	A	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:197404200A>C	ENST00000367397.1	+	5	2208	c.1350A>C	c.(1348-1350)ggA>ggC	p.G450G	CRB1_ENST00000367399.2_Silent_p.G957G|CRB1_ENST00000367400.3_Silent_p.G1069G|CRB1_ENST00000544212.1_Silent_p.G550G|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000535699.1_Silent_p.G1045G			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1069	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TTGCTACTGGAAGCCTCAACT	0.443000													4	118					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6472280	6472280	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:6472280C>T	ENST00000525074.1	-	9	2106	c.1712G>A	c.(1711-1713)gGa>gAa	p.G571E	TRIM3_ENST00000359518.3_Missense_Mutation_p.G571E|TRIM3_ENST00000536344.1_Missense_Mutation_p.G452E|TRIM3_ENST00000537602.1_Missense_Mutation_p.G493E|TRIM3_ENST00000345851.3_Missense_Mutation_p.G571E	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	571					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCGGCCAGCTCCAATCTTGGT	0.527000													11	49					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65350558	65350558	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65350558G>T	ENST00000309295.4	+	9	2680	c.2415G>T	c.(2413-2415)gaG>gaT	p.E805D		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	805	Glu-rich.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						GGGGTTCAGAGGTTCCAGAGA	0.522000													14	49					4.3838e-07	4.72595e-07	1	1	0
HAPLN3	145864	broad.mit.edu	37	15	89424836	89424836	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr15:89424836C>T	ENST00000359595.3	-	3	459	c.245G>A	c.(244-246)cGg>cAg	p.R82Q	HAPLN3_ENST00000562889.1_Missense_Mutation_p.R144Q	NM_178232.2	NP_839946.1	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	82	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	17	Lung NSC(78;0.0392)|all_lung(78;0.077)					ACGCACACGCCGCGGGGAGAC	0.662000													31	117					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349860	65349860	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr11:65349860G>T	ENST00000309295.4	+	9	1982	c.1717G>T	c.(1717-1719)Gag>Tag	p.E573*		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	573	Glu-rich.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						CCTGGAAACAGAGACTGAGGT	0.582000													12	41					5.50884e-06	5.76992e-06	1	1	0
XDH	7498	broad.mit.edu	37	2	31570414	31570414	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr2:31570414C>T	ENST00000379416.3	-	29	3298	c.3250G>A	c.(3250-3252)Gct>Act	p.A1084T		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1084					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTGAGGTCAGCGCTGACAGAG	0.587000													4	118					0	0	1	0	0
ZBTB1	22890	broad.mit.edu	37	14	64988828	64988828	+	Silent	SNP	T	T	C			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr14:64988828T>C	ENST00000358738.3	+	2	997	c.606T>C	c.(604-606)tcT>tcC	p.S202S	ZBTB1_ENST00000554015.1_Silent_p.S202S|ZBTB1_ENST00000394712.2_Silent_p.S202S|RP11-973N13.4_ENST00000554918.1_RNA	NM_014950.2	NP_055765.2	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	13		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		CCAAATTATCTACTCCAAAAG	0.388000													27	122					0	0	1	0	0
CYP39A1	51302	broad.mit.edu	37	6	46620227	46620227	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:46620227G>A	ENST00000275016.2	-	1	296	c.93C>T	c.(91-93)tgC>tgT	p.C31C		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	31					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						AGCCCTTGATGCACGGGGGTC	0.448000													68	331					0	0	1	0	0
SYNE4	163183	broad.mit.edu	37	19	36497710	36497710	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:36497710C>T	ENST00000324444.3	-	4	671	c.560G>A	c.(559-561)cGa>cAa	p.R187Q	SYNE4_ENST00000340477.5_Intron	NM_001039876.1	NP_001034965.1			spectrin repeat containing, nuclear envelope family member 4																		GATGGAGTCTCGGTAAGCTCC	0.677000													7	24					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63491992	63491992	+	Silent	SNP	G	G	A			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr18:63491992G>A	ENST00000536984.2	+	6	1600	c.906G>A	c.(904-906)gtG>gtA	p.V302V	CDH7_ENST00000397968.2_Silent_p.V302V|CDH7_ENST00000323011.3_Silent_p.V302V			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	302	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				ACAAGATTGTGGATGGTGATG	0.378000													5	55					0	0	1	0	0
DNAJB4	11080	broad.mit.edu	37	1	78470850	78470853	+	Frame_Shift_Del	DEL	ATAT	ATAT	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:78470850_78470853delATAT	ENST00000370763.5	+	1	313_316	c.56_59delATAT	c.(55-60)gtfs	p.DI19fs	DNAJB4_ENST00000487931.1_Intron|GIPC2_ENST00000476882.1_Intron	NM_007034.3	NP_008965.2	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	19	J.				protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						TCAGATGAAGATATTAAAAAGGCT	0.363													41	123	---	---	---	---					
CACNA1E	777	broad.mit.edu	37	1	181726170	181726173	+	Frame_Shift_Del	DEL	TTCT	TTCT	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr1:181726170_181726173delTTCT	ENST00000526775.1	+	29	4345_4348	c.4180_4183delTTCT	c.(4180-4185)ttfs	p.FF1394fs	CACNA1E_ENST00000358338.5_Frame_Shift_Del_p.FF1345fs|CACNA1E_ENST00000367573.2_Frame_Shift_Del_p.FF1413fs|CACNA1E_ENST00000367567.4_Frame_Shift_Del_p.FF1020fs|CACNA1E_ENST00000367570.1_Frame_Shift_Del_p.FF1413fs|CACNA1E_ENST00000357570.5_Frame_Shift_Del_p.FF1364fs|CACNA1E_ENST00000360108.3_Frame_Shift_Del_p.FF1394fs	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1413					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.F1414L(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTCCCCTTCTTCTTTGTCAATAT	0.475													29	73	---	---	---	---					
BCLAF1	9774	broad.mit.edu	37	6	136599260	136599261	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr6:136599260_136599261delAG	ENST00000531224.1	-	4	1010_1011	c.758_759delCT	c.(757-759)tfs	p.S253fs	BCLAF1_ENST00000530767.1_Frame_Shift_Del_p.S253fs|BCLAF1_ENST00000353331.4_Frame_Shift_Del_p.S251fs|BCLAF1_ENST00000527536.1_Frame_Shift_Del_p.S253fs|BCLAF1_ENST00000392348.2_Frame_Shift_Del_p.S251fs|BCLAF1_ENST00000527759.1_Frame_Shift_Del_p.S251fs	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	253					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TATTTTTTGCAGAGTGAACTGT	0.446													15	116	---	---	---	---					
TAS2R60	338398	broad.mit.edu	37	7	143141293	143141294	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr7:143141293_143141294delCT	ENST00000332690.1	+	1	748_749	c.748_749delCT	c.(748-750)cfs	p.L250fs	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	250					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					GCTGGCTCTCCTCTCTTTTGCC	0.495													18	101	---	---	---	---					
FLYWCH1	84256	broad.mit.edu	37	16	2986360	2986362	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr16:2986360_2986362delTCC	ENST00000399667.2	+	8	1957_1959	c.1594_1596delTCC	c.(1594-1596)del	p.S533del	FLYWCH1_ENST00000416288.2_Intron|FLYWCH1_ENST00000570752.1_3'UTR|FLYWCH1_ENST00000253928.9_Intron			Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1	505						nucleus	DNA binding|metal ion binding			kidney(1)|lung(3)	4						CCCCTCAGGGTCCTCCTGCCTCC	0.680													2	4	---	---	---	---					
RPL23AP87	388574	broad.mit.edu	37	17	81188370	81188371	+	RNA	DEL	AT	AT	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr17:81188370_81188371delAT	ENST00000425566.1	+	0	2053_2054					NR_029406.1																						aattttgaagatacagttgttt	0.223													2	4	---	---	---	---					
HIPK4	147746	broad.mit.edu	37	19	40885564	40885565	+	Frame_Shift_Ins	INS	-	-	G			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr19:40885564_40885565insG	ENST00000291823.2	-	4	2064_2065	c.1780_1781insC	c.(1780-1782)ccgfs	p.P594fs		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	594						cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GTGGGAGCGGCGGGGTGGGAGC	0.678													2	4	---	---	---	---					
CECR2	27443	broad.mit.edu	37	22	17979677	17979677	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr22:17979677delA	ENST00000262608.8	+	4	437	c.437delA	c.(436-438)cafs	p.Q146fs	CECR2_ENST00000400585.2_Frame_Shift_Del_p.Q24fs|CECR2_ENST00000400573.4_Frame_Shift_Del_p.Q165fs|CECR2_ENST00000342247.5_Frame_Shift_Del_p.Q145fs	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	187					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGTGAAGGACAAAAAAATGTC	0.363													2	4	---	---	---	---					
CRKL	1399	broad.mit.edu	37	22	21304075	21304075	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chr22:21304075delT	ENST00000354336.3	+	3	1363	c.854delT	c.(853-855)ctfs	p.L285fs		NM_005207.3	NP_005198.1	P46109	CRKL_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog-like	285	SH3 2.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)	14	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			CGCAAAGGGCTTTTCCCCTTT	0.468													8	1078	---	---	---	---					
PCYT1B	9468	broad.mit.edu	37	X	24593404	24593404	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IQ-A61H-01A-11D-A30E-08	TCGA-IQ-A61H-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba951306-939e-41b5-9eb3-edf2073c4920	50084462-d5a5-4110-98ec-430d14046af3	g.chrX:24593404delT	ENST00000379145.1	-	7	730	c.686delA	c.(685-687)gcfs	p.D229fs	PCYT1B_ENST00000356768.4_Frame_Shift_Del_p.D247fs|PCYT1B_ENST00000492876.1_5'UTR|PCYT1B_ENST00000379144.2_Frame_Shift_Del_p.D247fs	NM_001163264.1	NP_001156736.1	Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta	247	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	CTTCATTTTGTCCACTTGGTT	0.378													15	22	---	---	---	---					
