Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HSPA6	3310	broad.mit.edu	37	1	161495032	161495032	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:161495032G>A	ENST00000309758.4	+	1	997	c.584G>A	c.(583-585)cGc>cAc	p.R195H		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	195					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCGGGAGAGCGCAACGTGCTC	0.627000													15	55					0	0	1	0	0
CPT2	1376	broad.mit.edu	37	1	53676457	53676457	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:53676457G>A	ENST00000371486.3	+	4	1626	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	RP5-1024G6.2_ENST00000452466.1_RNA	NM_000098.2	NP_000089.1	P23786	CPT2_HUMAN	carnitine palmitoyltransferase 2	371					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	15					L-Carnitine(DB00583)|Perhexiline(DB01074)	CGTCCACTTTGAGCACTCTTG	0.498000													14	27					0	0	1	0	0
TMOD1	7111	broad.mit.edu	37	9	100308588	100308588	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:100308588G>A	ENST00000395211.2	+	3	378	c.242G>A	c.(241-243)cGa>cAa	p.R81Q	TMOD1_ENST00000259365.3_Missense_Mutation_p.R81Q	NM_001166116.1	NP_001159588.1	P28289	TMOD1_HUMAN	tropomodulin 1	81	Tropomyosin-binding (Potential).				muscle filament sliding	cytosol	actin binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		TTTAAGGACCGAGAAGATCTG	0.502000													11	126					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77817474	77817474	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr4:77817474G>A	ENST00000334306.2	-	1	1528	c.1529C>T	c.(1528-1530)tCt>tTt	p.S510F		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	510																	CTCCTCATCAGAGGAGGACAA	0.592000													23	39					0	0	1	0	0
B4GALT3	8703	broad.mit.edu	37	1	161142103	161142103	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:161142103C>A	ENST00000319769.5	-	7	1044	c.822G>T	c.(820-822)atG>atT	p.M274I	PPOX_ENST00000432542.2_Intron|PPOX_ENST00000495483.1_Intron|B4GALT3_ENST00000470882.1_5'UTR|B4GALT3_ENST00000367998.1_Missense_Mutation_p.M274I|PPOX_ENST00000535223.1_Intron	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	274					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	GAGAGATCTTCATCCCAGCCA	0.488000													14	33					7.93312e-07	8.0821e-07	1	1	0
CCDC129	223075	broad.mit.edu	37	7	31682734	31682734	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr7:31682734G>C	ENST00000319386.3	+	11	2299	c.1306G>C	c.(1306-1308)Gag>Cag	p.E436Q	CCDC129_ENST00000407970.3_Missense_Mutation_p.E584Q|CCDC129_ENST00000409210.1_Missense_Mutation_p.E492Q|CCDC129_ENST00000451887.2_Missense_Mutation_p.E610Q			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	584										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TGTGAGGCCTGAGGGAGCTGG	0.493000													7	166					0	0	1	0	0
ZNF273	10793	broad.mit.edu	37	7	64389280	64389280	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr7:64389280G>A	ENST00000476120.1	+	4	1645	c.1574G>A	c.(1573-1575)cGg>cAg	p.R525Q	ZNF273_ENST00000319636.5_Missense_Mutation_p.R460Q|ZNF273_ENST00000527278.1_3'UTR	NM_021148.2	NP_066971.2	Q14593	ZN273_HUMAN	zinc finger protein 273	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				GCTTTTAACCGGTCCTCAAAC	0.388000													4	91					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31227742	31227742	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chrX:31227742C>T	ENST00000357033.4	-	65	9642	c.9436G>A	c.(9436-9438)Gat>Aat	p.D3146N	DMD_ENST00000378723.3_Missense_Mutation_p.D78N|DMD_ENST00000378677.2_Missense_Mutation_p.D3142N|DMD_ENST00000541735.1_Missense_Mutation_p.D686N|DMD_ENST00000361471.4_Missense_Mutation_p.D78N|DMD_ENST00000474231.1_Missense_Mutation_p.D686N|DMD_ENST00000378702.4_Missense_Mutation_p.D78N|DMD_ENST00000359836.1_Missense_Mutation_p.D686N|DMD_ENST00000378707.3_Missense_Mutation_p.D686N|DMD_ENST00000378680.2_Missense_Mutation_p.D78N|DMD_ENST00000343523.2_Missense_Mutation_p.D686N	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3146	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCAGGATATCCATGGGCTGG	0.443000													20	41					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867629	6867629	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:6867629T>C	ENST00000299454.4	+	1	747	c.716T>C	c.(715-717)tTc>tCc	p.F239S	OR10A5_ENST00000379831.2_Missense_Mutation_p.F243S			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CATAAAGCCTTCTCTACGTGC	0.458000													8	172					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42139713	42139713	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:42139713C>T	ENST00000382448.4	+	24	2828	c.2819C>T	c.(2818-2820)tCg>tTg	p.S940L	JMJD7-PLA2G4B_ENST00000342159.4_Intron|JMJD7-PLA2G4B_ENST00000458483.1_Missense_Mutation_p.S709L|PLA2G4B_ENST00000452633.1_Missense_Mutation_p.S709L	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		709					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						CGGGAGTACTCGGCCCCTGGT	0.667000													29	84					0	0	1	0	0
SREBF1	6720	broad.mit.edu	37	17	17722964	17722964	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:17722964G>T	ENST00000355815.4	-	4	858	c.689C>A	c.(688-690)tCc>tAc	p.S230Y	SREBF1_ENST00000338854.5_Missense_Mutation_p.S200Y|SREBF1_ENST00000435530.2_Missense_Mutation_p.S200Y|SREBF1_ENST00000395757.1_5'UTR|SREBF1_ENST00000583732.1_Intron|SREBF1_ENST00000261646.5_Missense_Mutation_p.S200Y	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	200					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						GGTGTGCAAGGAGACGGGCGG	0.662000													8	26					0.000274275	0.000274275	1	1	0
PCDHB8	56128	broad.mit.edu	37	5	140558805	140558805	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:140558805C>T	ENST00000239444.2	+	1	1435	c.1190C>T	c.(1189-1191)tCt>tTt	p.S397F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		397	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGAAATCTTCTGTGGGGAAC	0.463000													6	145					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24832954	24832954	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr10:24832954C>T	ENST00000376451.2	+	14	4064	c.3804C>T	c.(3802-3804)ctC>ctT	p.L1268L	KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000376454.3_Silent_p.L1585L|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000307544.6_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1585					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TCGCCGCTCTCACTCAAGCCA	0.468000													59	87					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9009317	9009317	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:9009317G>T	ENST00000344836.4	-	9	1170	c.972C>A	c.(970-972)ttC>ttA	p.F324L	USP7_ENST00000381886.4_Missense_Mutation_p.F308L|USP7_ENST00000535863.1_Missense_Mutation_p.F225L	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	324					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						TTTTGCCGCGGAATAATTTGG	0.338000													14	35					6.72482e-11	7.0158e-11	1	1	0
MAST2	23139	broad.mit.edu	37	1	46496348	46496348	+	Silent	SNP	C	C	T	rs12757963		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:46496348C>T	ENST00000361297.2	+	22	2906	c.2623C>T	c.(2623-2625)Ctg>Ttg	p.L875L	MAST2_ENST00000372008.1_Silent_p.L760L|MAST2_ENST00000372009.2_Silent_p.L805L	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	875					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CAAGCGCAGCCTGAGTGAGGA	0.647000													5	12					0	0	1	0	0
NUCB1	4924	broad.mit.edu	37	19	49404064	49404064	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:49404064C>T	ENST00000405315.4	+	2	345	c.11C>T	c.(10-12)tCt>tTt	p.S4F	NUCB1_ENST00000263273.5_Missense_Mutation_p.S4F|NUCB1_ENST00000407032.1_Missense_Mutation_p.S4F|NUCB1_ENST00000485798.1_Intron	NM_006184.5	NP_006175.2	Q02818	NUCB1_HUMAN	nucleobindin 1	4						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding			cervix(1)|endometrium(4)|large_intestine(4)|lung(8)	17		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		ATGCCTCCCTCTGGGCCCCGA	0.652000													6	65					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	130987593	130987593	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:130987593C>T	ENST00000307968.7	-	15	3123	c.3124G>A	c.(3124-3126)Gat>Aat	p.D1042N	FNIP1_ENST00000510461.1_Missense_Mutation_p.D1070N|FNIP1_ENST00000307954.8_Missense_Mutation_p.D1025N|FNIP1_ENST00000514667.1_Intron	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		AATTTATTATCTGTCACTCGT	0.398000													12	27					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64812754	64812754	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:64812754C>T	ENST00000358658.3	-	18	2239	c.2212G>A	c.(2212-2214)Gct>Act	p.A738T	NAALADL1_ENST00000355369.2_3'UTR|NAALADL1_ENST00000355721.3_Missense_Mutation_p.A697T|NAALADL1_ENST00000340252.4_Missense_Mutation_p.A789T|NAALADL1_ENST00000339885.2_3'UTR|NAALADL1_ENST00000356632.3_Missense_Mutation_p.A703T|NAALADL1_ENST00000526799.1_Missense_Mutation_p.A85T	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	738					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CAGAGGTCAGCCACAGGCCTC	0.597000													5	16					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004819	75004819	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chrX:75004819C>G	ENST00000373359.2	-	1	260	c.68G>C	c.(67-69)aGa>aCa	p.R23T		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	23										autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TATTTCACCTCTGCCGTCGCC	0.577000													18	35					0	0	1	0	0
MED14	9282	broad.mit.edu	37	X	40572268	40572268	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chrX:40572268C>T	ENST00000324817.1	-	6	797	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K		NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	227	Interaction with STAT2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AATTCTCCTTCAACACGAAAC	0.413000													19	36					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													5	41					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121380	38121380	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr22:38121380C>T	ENST00000406386.3	+	7	3072	c.2817C>T	c.(2815-2817)ctC>ctT	p.L939L	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	939					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCATCGCCCTCCGGCCAACCC	0.637000													52	150					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128324312	128324312	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:128324312G>A	ENST00000262462.4	+	3	1715	c.705G>A	c.(703-705)gtG>gtA	p.V235V	SLC27A6_ENST00000395266.1_Silent_p.V235V|SLC27A6_ENST00000506176.1_Silent_p.V235V			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	235					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AAGCAGCTGTGATTAGTCAGC	0.363000													29	55					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139820216	139820216	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:139820216C>T	ENST00000359662.3	+	11	1570	c.1525C>T	c.(1525-1527)Cag>Tag	p.Q509*	TRAF2_ENST00000247668.2_Nonsense_Mutation_p.Q457*|TRAF2_ENST00000536468.1_Nonsense_Mutation_p.Q457*			Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	457					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		ATCCTCTTTTCAGAGGCCAGT	0.572000													20	48					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008395	120008395	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:120008395C>T	ENST00000341846.5	-	1	766	c.345G>A	c.(343-345)aaG>aaA	p.K115K		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	115					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CGGGTGGCTTCTTGGCAGCCC	0.607000													24	267					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40259877	40259877	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:40259877C>T	ENST00000263791.5	+	9	1393	c.1350C>T	c.(1348-1350)ctC>ctT	p.L450L	EIF2AK4_ENST00000559624.1_Silent_p.L450L|EIF2AK4_ENST00000382727.2_Silent_p.L450L	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	450	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CTAAGCGCCTCGCAGACATTT	0.468000													4	70					0	0	1	0	0
GTF2E1	2960	broad.mit.edu	37	3	120469577	120469577	+	Nonsense_Mutation	SNP	C	C	T	rs139408677	byFrequency	TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr3:120469577C>T	ENST00000283875.5	+	2	271	c.178C>T	c.(178-180)Cga>Tga	p.R60*		NM_005513.2	NP_005504.2	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1, alpha 56kDa	60	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding	p.R60*(1)		NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)	22				GBM - Glioblastoma multiforme(114;0.159)		GAAGCAACTTCGATCAGTTTT	0.448000													5	62					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115409891	115409891	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr10:115409891G>A	ENST00000369358.4	-	9	1037	c.793C>T	c.(793-795)Cat>Tat	p.H265Y	NRAP_ENST00000360478.3_Missense_Mutation_p.H265Y|NRAP_ENST00000359988.3_Missense_Mutation_p.H265Y|NRAP_ENST00000369360.3_Missense_Mutation_p.H265Y			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	265						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TATTGTTGATGGTACCTCACC	0.443000													39	88					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106128284	106128284	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr10:106128284C>T	ENST00000369704.3	+	6	1030	c.896C>T	c.(895-897)tCc>tTc	p.S299F	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	299										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAGCAGCTATCCCAGGAAAAC	0.438000													23	39					0	0	1	0	0
PHF19	26147	broad.mit.edu	37	9	123631545	123631545	+	Missense_Mutation	SNP	A	A	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:123631545A>C	ENST00000373896.3	-	6	781	c.529T>G	c.(529-531)Tcc>Gcc	p.S177A		NM_015651.1	NP_056466.1	Q5T6S3	PHF19_HUMAN	PHD finger protein 19	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGCTGGTAGGACAGCACCATC	0.672000													8	12					0	0	1	0	0
RABL6	55684	broad.mit.edu	37	9	139734271	139734271	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:139734271C>T	ENST00000371675.3	+	13	2424	c.1539C>T	c.(1537-1539)ttC>ttT	p.F513F	RABL6_ENST00000371663.4_Silent_p.F629F|RABL6_ENST00000311502.7_Silent_p.F628F|RABL6_ENST00000357466.2_Intron|RABL6_ENST00000432842.2_3'UTR					RAB, member RAS oncogene family-like 6																		CGGACCTCTTCGGGCTGGGGC	0.662000													8	40					0	0	1	0	0
NUP50	10762	broad.mit.edu	37	22	45574294	45574294	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr22:45574294G>A	ENST00000347635.3	+	5	982	c.516G>A	c.(514-516)gtG>gtA	p.V172V	NUP50_ENST00000486184.1_3'UTR|NUP50_ENST00000407019.2_Silent_p.V144V|NUP50_ENST00000396096.2_Silent_p.V144V|NUP50_ENST00000425733.2_5'UTR	NM_007172.3	NP_009103.2	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa	172	5 X 2 AA repeats of F-G.|Binding to CDKN1B (By similarity).				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		ATTGGATAGTGAAGCACGTGA	0.483000													14	48					0	0	1	0	0
CYB5R4	51167	broad.mit.edu	37	6	84569524	84569524	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr6:84569524C>T	ENST00000369681.4	+	1	163	c.23C>T	c.(22-24)tCt>tTt	p.S8F	CYB5R4_ENST00000369679.4_5'UTR	NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	8					cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		CCTTCCCAGTCTTTCCCGGCC	0.701000											OREG0017553	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	16					0	0	1	0	0
KAT7	11143	broad.mit.edu	37	17	47895328	47895328	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:47895328C>T	ENST00000503935.2	+	9	1678	c.642C>T	c.(640-642)ttC>ttT	p.F214F	KAT7_ENST00000510819.1_Silent_p.F201F|KAT7_ENST00000509773.1_Silent_p.F260F|KAT7_ENST00000454930.2_Silent_p.F231F|KAT7_ENST00000435742.2_Silent_p.F184F|KAT7_ENST00000424009.2_Silent_p.F340F|KAT7_ENST00000259021.4_Silent_p.F370F|KAT7_ENST00000513980.1_Intron			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7	370					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										TGTGTGAATTCTGTTTAAAAT	0.438000													17	32					0	0	1	0	0
RABL6	55684	broad.mit.edu	37	9	139734268	139734268	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:139734268C>T	ENST00000371675.3	+	13	2421	c.1536C>T	c.(1534-1536)ctC>ctT	p.L512L	RABL6_ENST00000371663.4_Silent_p.L628L|RABL6_ENST00000311502.7_Silent_p.L627L|RABL6_ENST00000357466.2_Intron|RABL6_ENST00000432842.2_3'UTR					RAB, member RAS oncogene family-like 6																		ACTCGGACCTCTTCGGGCTGG	0.662000													8	40					0	0	1	0	0
BAMBI	25805	broad.mit.edu	37	10	28970441	28970441	+	Missense_Mutation	SNP	G	G	A	rs111458570		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr10:28970441G>A	ENST00000375533.3	+	2	887	c.331G>A	c.(331-333)Gat>Aat	p.D111N		NM_012342.2	NP_036474.1	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	111					cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding			central_nervous_system(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	17						AGGGCTGCACGATGTTCTCTC	0.527000													33	59					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													3	32					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19501748	19501748	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:19501748C>T	ENST00000396229.2	+	18	3354	c.2605C>T	c.(2605-2607)Cga>Tga	p.R869*	TMC5_ENST00000564959.1_Nonsense_Mutation_p.R552*|TMC5_ENST00000561503.1_Nonsense_Mutation_p.R510*|TMC5_ENST00000542583.2_Nonsense_Mutation_p.R869*|TMC5_ENST00000541464.1_Nonsense_Mutation_p.R817*|TMC5_ENST00000381414.4_Intron|TMC5_ENST00000219821.5_Nonsense_Mutation_p.R623*	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	869						integral to membrane		p.R869*(2)|p.R623*(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TGGCCCTTTTCGAGGTCTGCC	0.483000													6	151					0	0	1	0	0
RIBC1	158787	broad.mit.edu	37	X	53455326	53455326	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chrX:53455326C>T	ENST00000457095.1	+	5	499	c.295C>T	c.(295-297)Cgg>Tgg	p.R99W	RIBC1_ENST00000414955.2_Intron|RIBC1_ENST00000375327.3_Missense_Mutation_p.R99W	NM_144968.2	NP_659405.1	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1	99										lung(2)	2						CCAGGAGTTTCGGGAGCAGAA	0.512000													13	13					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559795	140559795	+	Nonsense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:140559795C>G	ENST00000239444.2	+	1	2425	c.2180C>G	c.(2179-2181)tCa>tGa	p.S727*		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		727					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCGCTGCTCAGTGCCTGAG	0.647000													9	191					0	0	1	0	0
CKLF	51192	broad.mit.edu	37	16	66599825	66599825	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:66599825G>A	ENST00000264001.4	+	4	519	c.370G>A	c.(370-372)Gac>Aac	p.D124N	CKLF_ENST00000362093.4_Missense_Mutation_p.D39N|CKLF_ENST00000351137.4_Missense_Mutation_p.D71N|CKLF_ENST00000345436.4_Missense_Mutation_p.D92N|CKLF_ENST00000563092.1_3'UTR|CKLF-CMTM1_ENST00000527729.1_Intron|CKLF_ENST00000532838.1_Intron|CKLF_ENST00000417030.2_Intron	NM_016951.3	NP_058647.1			chemokine-like factor											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|upper_aerodigestive_tract(1)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0689)|Epithelial(162;0.217)		CTGTCTTGCCGACGGGGCCCT	0.448000													9	56					0	0	1	0	0
ZNF397	84307	broad.mit.edu	37	18	32822651	32822651	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr18:32822651G>A	ENST00000330501.7	+	2	370	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	ZNF397_ENST00000592264.1_Missense_Mutation_p.E73K|ZNF397_ENST00000589420.1_Intron|ZNF397_ENST00000261333.6_Missense_Mutation_p.E73K|ZNF397_ENST00000585800.1_Missense_Mutation_p.E73K|ZNF397_ENST00000355632.4_Missense_Mutation_p.E73K|ZNF397_ENST00000591206.1_Missense_Mutation_p.E73K	NM_001135178.2	NP_001128650.1	Q8NF99	ZN397_HUMAN	zinc finger protein 397	73	SCAN box.				viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)	12						CCGACTCCAGGAACTTTGCTA	0.512000													17	63					0	0	1	0	0
RIPPLY1	92129	broad.mit.edu	37	X	106144027	106144027	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chrX:106144027G>A	ENST00000276173.4	-	4	437	c.408C>T	c.(406-408)agC>agT	p.S136S	CLDN2_ENST00000541806.1_Intron|RIPPLY1_ENST00000411805.1_Silent_p.S89S	NM_138382.2	NP_612391.1	Q0D2K3	RIPP1_HUMAN	ripply transcriptional repressor 1	136					negative regulation of transcription, DNA-dependent|somite rostral/caudal axis specification|somite specification|transcription, DNA-dependent	nucleus				lung(1)|urinary_tract(1)	2						cttcttcttcGCTGTCTGAGT	0.502000													9	24					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43526973	43526973	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:43526973C>T	ENST00000220420.5	-	11	1876	c.1869G>A	c.(1867-1869)acG>acA	p.T623T	TGM5_ENST00000349114.4_Silent_p.T541T	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	623					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CTACATTAATCGTGATGCTTG	0.542000													4	66					0	0	1	0	0
ZNF561	93134	broad.mit.edu	37	19	9721241	9721241	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:9721241G>A	ENST00000302851.3	-	6	1459	c.1096C>T	c.(1096-1098)Cag>Tag	p.Q366*	ZNF561_ENST00000424629.1_Nonsense_Mutation_p.Q297*|ZNF561_ENST00000326044.5_3'UTR|ZNF561_ENST00000354661.4_Nonsense_Mutation_p.Q230*	NM_152289.2	NP_689502.2	Q8N587	ZN561_HUMAN	zinc finger protein 561	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	14						TCCTTACACTGATAGGGTTTC	0.423000													33	69					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84438772	84438772	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:84438772G>A	ENST00000416219.2	+	3	338	c.249G>A	c.(247-249)acG>acA	p.T83T	ATP2C2_ENST00000262429.4_Silent_p.T83T			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	83					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						TCTCGGTGACGCAGCGCCGGC	0.562000													4	37					0	0	1	0	0
LOC101927648	101927648	broad.mit.edu	37	1	143403554	143403554	+	RNA	SNP	T	T	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:143403554T>G	ENST00000423249.1	-	0	59																											GGAACAGGATTTCTTTGGCCA	0.468000													3	9					0	0	1	0	0
TAPT1-AS1	202020	broad.mit.edu	37	4	16258189	16258189	+	RNA	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr4:16258189C>T	ENST00000570786.1	+	0	544				TAPT1-AS1_ENST00000573950.1_RNA|TAPT1-AS1_ENST00000573308.1_RNA	NR_027696.1																						TTCGAGGCTCCGCCTGCTGCC	0.592000													3	8					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	130987601	130987601	+	Missense_Mutation	SNP	C	C	T	rs138667282		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:130987601C>T	ENST00000307968.7	-	15	3115	c.3116G>A	c.(3115-3117)cGa>cAa	p.R1039Q	FNIP1_ENST00000510461.1_Missense_Mutation_p.R1067Q|FNIP1_ENST00000307954.8_Missense_Mutation_p.R1022Q|FNIP1_ENST00000514667.1_Intron	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		ATCTGTCACTCGTCTCTGGCT	0.403000													14	28					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166330	19166330	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:19166330G>A	ENST00000375371.3	-	6	2304	c.2283C>T	c.(2281-2283)ttC>ttT	p.F761F		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	761					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TGAGGGTGATGAACTTGGCCT	0.562000													10	30					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44537383	44537383	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:44537383G>A	ENST00000266534.3	+	4	593	c.466G>A	c.(466-468)Gct>Act	p.A156T	TMEM117_ENST00000536799.1_Intron|TMEM117_ENST00000551577.1_Missense_Mutation_p.A156T	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	156						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		CATGAAATTAGCTGCAGTAGG	0.413000													16	60					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79366851	79366851	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr4:79366851C>G	ENST00000264895.6	+	42	6281	c.5841C>G	c.(5839-5841)atC>atG	p.I1947M	FRAS1_ENST00000325942.6_Missense_Mutation_p.I1947M	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1946					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TTCACAGCATCAATATCACCA	0.373000													11	201					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43896333	43896333	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:43896333C>T	ENST00000450892.2	-	22	4313	c.4236G>A	c.(4234-4236)gaG>gaA	p.E1412E	STRC_ENST00000541030.1_Silent_p.E639E	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1412					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTCCAGGGTCTCTGGACCCA	0.562000													8	11					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144885676	144885676	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr8:144885676C>T	ENST00000356994.2	-	24	3486	c.3480G>A	c.(3478-3480)gtG>gtA	p.V1160V	SCRIB_ENST00000377533.3_Silent_p.V1079V|SCRIB_ENST00000320476.3_Silent_p.V1160V	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	1160	Interaction with ARHGEF7.|PDZ 4.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TCTGCTGGTTCACCTCCAACA	0.687000													13	13					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204438434	204438434	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:204438434C>G	ENST00000367187.3	-	3	1053	c.497G>C	c.(496-498)tGg>tCg	p.W166S	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.W166S	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	166	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			AGGGGTATCCCAGATAGAAGC	0.577000													9	157					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10476542	10476542	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:10476542C>T	ENST00000525621.1	-	7	1143	c.662G>A	c.(661-663)cGg>cAg	p.R221Q	TYK2_ENST00000529370.1_Missense_Mutation_p.R221Q|TYK2_ENST00000524462.1_Missense_Mutation_p.R36Q|TYK2_ENST00000264818.6_Missense_Mutation_p.R221Q	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	221	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCGGATATGCCGGCGGAAGGA	0.677000													6	17					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103410646	103410646	+	Silent	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr14:103410646G>C	ENST00000361246.2	-	30	4278	c.3990C>G	c.(3988-3990)ctC>ctG	p.L1330L		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1330	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CCGTGGCCATGAGCTGGCAGC	0.567000													15	23					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5925255	5925255	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:5925255G>A	ENST00000378156.4	-	27	3988	c.3723C>T	c.(3721-3723)gtC>gtT	p.V1241V	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	1241					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGGCCTGCGACGCAGGAGA	0.632000													10	14					0	0	1	0	0
AGTR1	185	broad.mit.edu	37	3	148459829	148459829	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr3:148459829C>T	ENST00000542281.1	+	4	1453	c.1007C>T	c.(1006-1008)aCg>aTg	p.T336M	AGTR1_ENST00000418473.2_Missense_Mutation_p.T336M|AGTR1_ENST00000404754.2_Missense_Mutation_p.T336M|AGTR1_ENST00000497524.1_Missense_Mutation_p.T336M|AGTR1_ENST00000402260.1_Missense_Mutation_p.T336M|AGTR1_ENST00000461609.1_Missense_Mutation_p.T336M|AGTR1_ENST00000349243.3_Missense_Mutation_p.T336M|AGTR1_ENST00000475347.1_Missense_Mutation_p.T336M|AGTR1_ENST00000474935.1_Missense_Mutation_p.T336M	NM_031850.3	NP_114038.4	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	336			T -> P (in dbSNP:rs1801021).		calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity	p.T336>?(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	AAAATGAGCACGCTTTCCTAC	0.408000													32	32					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2855702	2855702	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr8:2855702G>A	ENST00000602557.1	-	55	8766	c.8211C>T	c.(8209-8211)atC>atT	p.I2737I	CSMD1_ENST00000537824.1_Silent_p.I2736I|CSMD1_ENST00000520002.1_Silent_p.I2737I|CSMD1_ENST00000400186.3_Silent_p.I2679I|CSMD1_ENST00000542608.1_Silent_p.I2678I|CSMD1_ENST00000602723.1_Silent_p.I2679I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2737	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACCACATGTGATGGCTGTAG	0.453000													7	66					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38568201	38568201	+	Missense_Mutation	SNP	C	C	G	rs140969268		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr21:38568201C>G	ENST00000399017.2	+	42	8190	c.5443C>G	c.(5443-5445)Ctg>Gtg	p.L1815V	TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.L1815V|TTC3_ENST00000355666.1_Missense_Mutation_p.L1815V	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1815					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				CCAGGCAGCTCTGTCAGAACG	0.597000													27	37					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134351533	134351533	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:134351533G>T	ENST00000357304.4	+	15	4072	c.4017G>T	c.(4015-4017)tgG>tgT	p.W1339C	PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Intron|PRRC2B_ENST00000405995.1_Intron	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	1339							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						CAGGTCAGTGGCCAGGCAGGC	0.662000											OREG0019561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	51					1.01871e-10	1.05771e-10	1	1	0
NCR1	9437	broad.mit.edu	37	19	55424082	55424082	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:55424082C>T	ENST00000594765.1	+	7	780	c.755C>T	c.(754-756)gCc>gTc	p.A252V	NCR1_ENST00000291890.4_Missense_Mutation_p.A253V|NCR1_ENST00000447255.1_Missense_Mutation_p.A252V|NCR1_ENST00000338835.5_Missense_Mutation_p.A236V|NCR1_ENST00000357397.5_Missense_Mutation_p.A146V|NCR1_ENST00000350790.5_Missense_Mutation_p.A158V|NCR1_ENST00000598576.1_Missense_Mutation_p.A240V			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	253					cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		GATCACACTGCCCAGAATCTC	0.498000													34	39					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120351118	120351118	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:120351118G>A	ENST00000397843.2	+	38	4382	c.4216G>A	c.(4216-4218)Gat>Aat	p.D1406N	ARHGEF12_ENST00000532993.1_Missense_Mutation_p.D1303N|ARHGEF12_ENST00000356641.3_Missense_Mutation_p.D1387N	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1406					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		GGAAGAGAAGGATGTTAATTT	0.383000			T	MLL	AML								4	70					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53293763	53293763	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:53293763G>A	ENST00000552551.1	-	6	1209	c.777C>T	c.(775-777)atC>atT	p.I259I	KRT8_ENST00000546897.1_Silent_p.I259I|KRT8_ENST00000552150.1_Silent_p.I287I|KRT8_ENST00000293308.6_Silent_p.I259I			P05787	K2C8_HUMAN	keratin 8	259	Linker 12.|Rod.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTCAGCAATGATGCTGTCCA	0.582000													19	60					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141955354	141955354	+	Splice_Site	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr7:141955354C>T	ENST00000552471.1	-	2	499		c.e2+1		PRSS58_ENST00000547058.2_Splice_Site			Q8IYP2	PRS58_HUMAN	protease, serine, 58						proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						TTATCACTCACGGTAAATTGC	0.502000													21	58					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													5	21					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29693822	29693822	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr22:29693822G>C	ENST00000397938.2	+	13	1619	c.1300G>C	c.(1300-1302)Gat>Cat	p.D434H	EWSR1_ENST00000332035.6_Missense_Mutation_p.D378H|EWSR1_ENST00000414183.2_Missense_Mutation_p.D439H|EWSR1_ENST00000332050.6_Missense_Mutation_p.D361H|EWSR1_ENST00000331029.7_Missense_Mutation_p.D396H|EWSR1_ENST00000406548.1_Missense_Mutation_p.D433H	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	434	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TCCAGGGAAAGATTTTCAAGG	0.502000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								17	40					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135744048	135744048	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:135744048C>G	ENST00000375845.3	-	7	2424	c.2394G>C	c.(2392-2394)caG>caC	p.Q798H	MAP3K19_ENST00000392915.1_Missense_Mutation_p.Q815H|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000358371.4_Missense_Mutation_p.Q685H|MAP3K19_ENST00000315513.3_5'UTR	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		GGAATTCATTCTGTTTCATGG	0.393000													7	56					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20074123	20074123	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr22:20074123G>A	ENST00000351989.3	+	2	1066	c.637G>A	c.(637-639)Gaa>Aaa	p.E213K	DGCR8_ENST00000383024.2_Missense_Mutation_p.E213K|DGCR8_ENST00000407755.1_Missense_Mutation_p.E213K	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	213	Necessary for interaction with NCL.|Necessary for nuclear localization and retention.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					GGAGCTAGATGAAGAAGGAGC	0.473000													29	83					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30308938	30308938	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr21:30308938C>G	ENST00000361371.4	-	26	4714	c.4564G>C	c.(4564-4566)Gaa>Caa	p.E1522Q	LTN1_ENST00000389194.2_Missense_Mutation_p.E1568Q	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1522							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						GTTGGATTTTCTGGCATAAGC	0.423000													7	293					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203272	140203272	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:140203272G>A	ENST00000529859.1	+	1	1912	c.1912G>A	c.(1912-1914)Gag>Aag	p.E638K	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.E638K|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.E638K|PCDHA1_ENST00000394633.3_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTCTGGATGAGACCGAAGC	0.637000													18	135					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108380744	108380744	+	Silent	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:108380744C>G	ENST00000265843.4	-	6	5600	c.5490G>C	c.(5488-5490)ctG>ctC	p.L1830L	EXPH5_ENST00000443411.1_Silent_p.L1642L|EXPH5_ENST00000525344.1_Silent_p.L1823L|EXPH5_ENST00000428840.1_Silent_p.L1754L	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1830					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TCAGTCGACTCAGGGCATTGT	0.423000													25	38					0	0	1	0	0
PGD	5226	broad.mit.edu	37	1	10479725	10479725	+	Silent	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:10479725C>G	ENST00000538557.1	+	13	1576	c.1332C>G	c.(1330-1332)ctC>ctG	p.L444L	PGD_ENST00000498356.1_3'UTR|PGD_ENST00000270776.8_Silent_p.L457L|PGD_ENST00000541529.1_Silent_p.L435L			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	457					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CCTATGAACTCTTGGCCAAAC	0.582000													5	105					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154268973	154268973	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:154268973C>T	ENST00000285873.7	-	27	4342	c.4267G>A	c.(4267-4269)Gaa>Aaa	p.E1423K		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	1423					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTTTTTTCTTCTTTACTAGTG	0.348000													16	43					0	0	1	0	0
DHRS11	79154	broad.mit.edu	37	17	34951448	34951448	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:34951448C>T	ENST00000251312.5	+	2	407	c.195C>T	c.(193-195)atC>atT	p.I65I	DHRS11_ENST00000590554.1_5'UTR|DHRS11_ENST00000394445.1_3'UTR	NM_024308.3	NP_077284.2	Q6UWP2	DHR11_HUMAN	dehydrogenase/reductase (SDR family) member 11	65						extracellular region	binding|oxidoreductase activity			endometrium(1)|lung(4)	5						GGACTTTGATCCCCTACAGAT	0.532000													25	49					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71840496	71840496	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:71840496G>A	ENST00000258104.3	+	40	4643	c.4366G>A	c.(4366-4368)Gtg>Atg	p.V1456M	DYSF_ENST00000429174.2_Missense_Mutation_p.V1456M|DYSF_ENST00000413539.2_Missense_Mutation_p.V1487M|DYSF_ENST00000410020.3_Missense_Mutation_p.V1474M|DYSF_ENST00000410041.1_Missense_Mutation_p.V1474M|DYSF_ENST00000409744.1_Missense_Mutation_p.V1443M|DYSF_ENST00000409762.1_Missense_Mutation_p.V1473M|DYSF_ENST00000409651.1_Missense_Mutation_p.V1488M|DYSF_ENST00000409582.3_Missense_Mutation_p.V1473M|DYSF_ENST00000409366.1_Missense_Mutation_p.V1457M|DYSF_ENST00000394120.2_Missense_Mutation_p.V1457M|DYSF_ENST00000479049.2_3'UTR	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1456						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TGGGGAAGACGTGCTCATCGA	0.612000													9	10					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27874638	27874638	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:27874638G>T	ENST00000374011.2	-	6	4957	c.3989C>A	c.(3988-3990)tCg>tAg	p.S1330*	AHDC1_ENST00000247087.5_Nonsense_Mutation_p.S1330*|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1330							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GAAGGCCCTCGACTGTGAGGG	0.612000													25	40					3.08376e-08	3.17145e-08	1	1	0
GPC1	2817	broad.mit.edu	37	2	241404610	241404610	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:241404610C>T	ENST00000264039.2	+	7	1499	c.1251C>T	c.(1249-1251)aaC>aaT	p.N417N		NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	417					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		GCTGCTGGAACGGGATGGCCA	0.667000													10	24					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58982230	58982230	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:58982230G>A	ENST00000536459.2	+	4	1080	c.371G>A	c.(370-372)aGa>aAa	p.R124K	ZNF324_ENST00000196482.3_Missense_Mutation_p.R124K			O75467	Z324A_HUMAN	zinc finger protein 324	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGCCTGCAGAGACAACGGGGT	0.602000													35	96					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25440081	25440081	+	RNA	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:25440081G>A	ENST00000424208.1	+	0	1460				SNORD115-14_ENST00000363090.1_RNA|SNHG14_ENST00000456576.1_RNA	NR_003305.1																						TCGATGATGAGAAACTTATAT	0.527000													13	273					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6471399	6471399	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:6471399C>T	ENST00000358945.3	-	3	1133	c.693G>A	c.(691-693)caG>caA	p.Q231Q	SCNN1A_ENST00000543768.1_Silent_p.Q254Q|SCNN1A_ENST00000396966.2_Silent_p.Q231Q|SCNN1A_ENST00000360168.3_Silent_p.Q290Q|SCNN1A_ENST00000540037.1_5'UTR|SCNN1A_ENST00000228916.2_Silent_p.Q231Q|SCNN1A_ENST00000538979.1_Intron			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	231					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	CCGATTTGTTCTGGTTGCACT	0.562000													33	68					0	0	1	0	0
FLOT2	2319	broad.mit.edu	37	17	27209406	27209406	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:27209406C>G	ENST00000394906.2	-	8	770	c.693G>C	c.(691-693)caG>caC	p.Q231H	FLOT2_ENST00000585169.1_Missense_Mutation_p.Q176H|FLOT2_ENST00000394908.4_Missense_Mutation_p.Q176H|FLOT2_ENST00000577789.1_5'UTR			Q14254	FLOT2_HUMAN	flotillin 2	176					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction				endometrium(3)|lung(6)|prostate(1)|urinary_tract(1)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			CAGCATCTCTCTGCACCACGG	0.587000													4	56					0	0	1	0	0
AKAP7	9465	broad.mit.edu	37	6	131571736	131571736	+	Nonsense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr6:131571736C>G	ENST00000342266.4	+	1	438	c.29C>G	c.(28-30)tCa>tGa	p.S10*	AKAP7_ENST00000263050.3_Intron|AKAP7_ENST00000431975.2_Intron|AKAP7_ENST00000368123.4_Intron|AKAP7_ENST00000474850.2_Nonsense_Mutation_p.S10*|AKAP7_ENST00000541650.1_Intron|AKAP7_ENST00000537868.1_Intron	NM_004842.3	NP_004833.1	O43687	AKA7A_HUMAN	A kinase (PRKA) anchor protein 7	10	Required for membrane localization.				intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|stomach(1)	13	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		TTTCCTTTCTCAAGAGATGAA	0.448000													6	60					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33565363	33565363	+	Missense_Mutation	SNP	G	G	A	rs61736871		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:33565363G>A	ENST00000321505.4	+	1	1543	c.1363G>A	c.(1363-1365)Gat>Aat	p.D455N	KIAA1549L_ENST00000265654.5_Missense_Mutation_p.D455N|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.D455N					KIAA1549-like																		TTCAGCTGCCGATGCCATAAA	0.423000											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	122					0	0	1	0	0
CYP51A1	1595	broad.mit.edu	37	7	91753166	91753166	+	Splice_Site	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr7:91753166G>A	ENST00000003100.8	-	6	937	c.770_splice	c.e6-1	p.R258_splice	CYP51A1_ENST00000450723.1_Splice_Site_p.R153_splice|LRRD1_ENST00000422722.1_5'UTR	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	252					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	CTGTCCCTGCGTCTGTAATTA	0.343000													12	24					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43221255	43221255	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr18:43221255G>A	ENST00000255226.6	+	8	1889	c.1073G>A	c.(1072-1074)gGa>gAa	p.G358E	SLC14A2_ENST00000586448.1_Missense_Mutation_p.G358E	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	358						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATCGCCATCGGAGGCATGTTC	0.552000													24	38					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168862	142168862	+	RNA	SNP	A	A	G	rs140095394	by1000genomes	TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr7:142168862A>G	ENST00000454561.2	-	0	183																											TGGGCCAGGCAGCACTGCACC	0.597000													5	26					0	0	1	0	0
USP1	7398	broad.mit.edu	37	1	62913122	62913122	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:62913122C>T	ENST00000339950.4	+	7	2175	c.1360C>T	c.(1360-1362)Caa>Taa	p.Q454*	USP1_ENST00000371146.1_Nonsense_Mutation_p.Q454*	NM_003368.4	NP_003359.3	O94782	UBP1_HUMAN	ubiquitin specific peptidase 1	454					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		AGAAGATTTTCAAGACATCAG	0.388000													15	28					0	0	1	0	0
CEP76	79959	broad.mit.edu	37	18	12697318	12697318	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr18:12697318C>T	ENST00000262127.2	-	5	835	c.610G>A	c.(610-612)Gag>Aag	p.E204K	RP11-973H7.2_ENST00000585331.1_RNA|CEP76_ENST00000423709.2_Missense_Mutation_p.E129K	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	204					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AAAGTCGTCTCACCAAATATG	0.388000													24	48					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30308975	30308975	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr21:30308975C>T	ENST00000361371.4	-	26	4677	c.4527G>A	c.(4525-4527)ttG>ttA	p.L1509L	LTN1_ENST00000389194.2_Silent_p.L1555L	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1509							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						GCAATTTATTCAAACTCTTTG	0.388000													6	283					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66191233	66191233	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:66191233G>A	ENST00000409699.2	-	22	2979	c.2807C>T	c.(2806-2808)tCc>tTc	p.S936F	MEGF11_ENST00000288745.3_Missense_Mutation_p.S861F|MEGF11_ENST00000360698.4_3'UTR|MEGF11_ENST00000478721.1_5'UTR|MEGF11_ENST00000395625.2_Missense_Mutation_p.S861F|MEGF11_ENST00000422354.1_Missense_Mutation_p.S936F			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	936						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						GCTATTCAAGGAACAAGTACT	0.428000													4	62					0	0	1	0	0
FIP1L1	81608	broad.mit.edu	37	4	54257190	54257190	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr4:54257190G>A	ENST00000507166.1	+	8	520	c.520G>A	c.(520-522)Gat>Aat	p.D174N	FIP1L1_ENST00000337488.6_Missense_Mutation_p.D174N|FIP1L1_ENST00000306932.6_Missense_Mutation_p.D159N|FIP1L1_ENST00000507922.1_Missense_Mutation_p.D159N|FIP1L1_ENST00000358575.5_Missense_Mutation_p.D159N			Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	174	Necessary for stimulating PAPOLA activity.|Sufficient for interaction with CPSF4.				mRNA processing	nucleus	RNA binding			large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGATCTTTCTGATTATTTTAA	0.294000			T	PDGFRA	idiopathic hypereosinophilic syndrome								13	43					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88270061	88270061	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:88270061C>A	ENST00000357081.3	-	11	1228	c.1084G>T	c.(1084-1086)Gaa>Taa	p.E362*	AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000376109.3_Nonsense_Mutation_p.E374*|AGTPBP1_ENST00000432218.1_Nonsense_Mutation_p.E200*|AGTPBP1_ENST00000376083.3_Nonsense_Mutation_p.E322*			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	362					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						ATCCTACCTTCAGGAGGTAAG	0.423000													6	26					8.12818e-05	8.16581e-05	1	1	0
SMARCAL1	50485	broad.mit.edu	37	2	217279495	217279495	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:217279495G>A	ENST00000357276.4	+	3	398	c.68G>A	c.(67-69)cGc>cAc	p.R23H	SMARCAL1_ENST00000358207.5_Missense_Mutation_p.R23H	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	23					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GCTCTGGCCCGCAGAGCTGAG	0.493000									Schimke Immuno-Osseous Dysplasia				4	120					0	0	1	0	0
CBX7	23492	broad.mit.edu	37	22	39530551	39530551	+	Silent	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr22:39530551G>C	ENST00000216133.5	-	5	658	c.453C>G	c.(451-453)ctC>ctG	p.L151L	CBX7_ENST00000401405.3_Intron|CBX7_ENST00000475962.1_Intron	NM_175709.3	NP_783640.1	O95931	CBX7_HUMAN	chromobox homolog 7	151					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	Melanoma(58;0.04)					TCTTGCGCGAGAGCCGCAGGT	0.697000													3	11					0	0	1	0	0
LINC00482	284185	broad.mit.edu	37	17	79279518	79279518	+	RNA	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:79279518G>A	ENST00000332012.5	-	0	378					NR_038080.1																						aggagcacgggaaccaggggg	0.632000													3	6					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101680212	101680212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:101680212G>A	ENST00000261637.4	+	5	614	c.440G>A	c.(439-441)tGg>tAg	p.W147*		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	147					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TTGTTAGAATGGGCTTTCACC	0.433000													45	108					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32635509	32635509	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:32635509C>T	ENST00000242310.4	-	1	158	c.69G>A	c.(67-69)tcG>tcA	p.S23S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	23					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCTCGCTGTCCGAGTCTGACA	0.567000													4	74					0	0	1	0	0
CABP5	56344	broad.mit.edu	37	19	48543884	48543884	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:48543884G>A	ENST00000293255.2	-	3	346	c.216C>T	c.(214-216)ctC>ctT	p.L72L		NM_019855.4	NP_062829.1	Q9NP86	CABP5_HUMAN	calcium binding protein 5	72	EF-hand 2.				signal transduction	cytoplasm	calcium ion binding			endometrium(1)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	11		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		TTTGCTGGCCGAGCTCAATCA	0.532000													25	45					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5462999	5462999	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:5462999C>T	ENST00000345221.3	-	4	1571	c.1017G>A	c.(1015-1017)ggG>ggA	p.G339G	NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000354411.3_Silent_p.G339G|NLRP1_ENST00000269280.4_Silent_p.G339G|NLRP1_ENST00000577119.1_Silent_p.G339G|NLRP1_ENST00000572272.1_Silent_p.G339G|NLRP1_ENST00000262467.5_Silent_p.G339G	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	339	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GTGTTGACTTCCCAATTCCAG	0.542000													37	118					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976943	119976943	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:119976943G>A	ENST00000313400.4	-	3	809	c.709C>T	c.(709-711)Cgc>Tgc	p.R237C	ASTN2_ENST00000373996.3_Missense_Mutation_p.R237C|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.R237C			O75129	ASTN2_HUMAN	astrotactin 2	237						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GGGATGCGGCGACGCTTCTGC	0.637000													29	34					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2538439	2538439	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:2538439G>A	ENST00000288709.6	-	7	818	c.578C>T	c.(577-579)gCg>gTg	p.A193V	MMEL1_ENST00000378412.3_Missense_Mutation_p.A202V|MMEL1_ENST00000502556.1_Intron	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	202					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CCTGTCCATCGCCACCGGCCA	0.632000													37	64					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54673360	54673360	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:54673360G>C	ENST00000376591.4	-	3	481	c.350C>G	c.(349-351)tCt>tGt	p.S117C	TMC4_ENST00000301187.4_Missense_Mutation_p.S111C|TMC4_ENST00000476013.2_5'UTR	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	117						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTTAGTTCCAGAGCCATAGAC	0.572000													20	55					0	0	1	0	0
CINP	51550	broad.mit.edu	37	14	102825817	102825817	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr14:102825817T>A	ENST00000216756.6	-	2	155	c.115A>T	c.(115-117)Acc>Tcc	p.T39S	CINP_ENST00000541568.2_Missense_Mutation_p.T39S|CINP_ENST00000536961.2_Missense_Mutation_p.T54S	NM_032630.2	NP_116019.1	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2 interacting protein	39					cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(2)|lung(2)	4						TCATTGAGGGTTTCCCACTTC	0.373000													20	41					0	0	1	0	0
RASIP1	54922	broad.mit.edu	37	19	49224135	49224135	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:49224135G>A	ENST00000222145.4	-	12	3016	c.2812C>T	c.(2812-2814)Cgc>Tgc	p.R938C		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	938					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		AGGAGGCGGCGGAGCCTACGG	0.652000													5	99					0	0	1	0	0
EIF4G2	1982	broad.mit.edu	37	11	10821737	10821737	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:10821737G>A	ENST00000526148.1	-	18	2529	c.2019C>T	c.(2017-2019)ctC>ctT	p.L673L	RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000396525.2_Silent_p.L635L|EIF4G2_ENST00000339995.5_Silent_p.L673L|EIF4G2_ENST00000525681.1_Silent_p.L673L	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	673					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAAGTAGGAAGAGAGGAAAAT	0.413000													13	53					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161043042	161043042	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:161043042G>A	ENST00000368012.3	-	8	1583	c.1281C>T	c.(1279-1281)ctC>ctT	p.L427L	PVRL4_ENST00000486694.1_Intron|PVRL4_ENST00000453926.2_Intron	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	427					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGTTGTCCTTGAGACTATCAG	0.652000													5	37					0	0	1	0	0
CCNF	899	broad.mit.edu	37	16	2487144	2487144	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:2487144G>A	ENST00000397066.4	+	5	449	c.361G>A	c.(361-363)Gag>Aag	p.E121K		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	121					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				TGTGTCTGATGAGGCCCGCGC	0.567000													6	143					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131339679	131339679	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:131339679C>T	ENST00000372739.3	+	8	1089	c.979C>T	c.(979-981)Ctg>Ttg	p.L327L	SPTAN1_ENST00000358161.5_Silent_p.L327L|SPTAN1_ENST00000372731.4_Silent_p.L327L	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	327					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GTCCCACCCTCTGAGTGCAAC	0.507000													33	57					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													6	24					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45515473	45515473	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:45515473C>T	ENST00000221452.8	+	4	593	c.443C>T	c.(442-444)tCg>tTg	p.S148L	RELB_ENST00000540120.1_Missense_Mutation_p.S148L|RELB_ENST00000505236.1_Missense_Mutation_p.S145L	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	148	RHD.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GAGGGCCGCTCGGCCGGCAGC	0.761000													20	15					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241492400	241492400	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:241492400G>A	ENST00000391987.1	-	4	510	c.144C>T	c.(142-144)ttC>ttT	p.F48F	ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000405002.1_Silent_p.F48F|ANKMY1_ENST00000405523.3_Silent_p.F137F|ANKMY1_ENST00000536462.1_Silent_p.F90F|ANKMY1_ENST00000272972.3_Silent_p.F48F|ANKMY1_ENST00000373318.2_Silent_p.F137F|ANKMY1_ENST00000373320.4_Silent_p.F48F|ANKMY1_ENST00000361678.4_Silent_p.F137F|ANKMY1_ENST00000406958.1_Silent_p.F137F|ANKMY1_ENST00000403283.1_Silent_p.F216F|ANKMY1_ENST00000401804.1_Silent_p.F137F			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	48							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		ATGTGCCCGTGAAACTGGAGC	0.552000													16	32					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366801	248366801	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:248366801G>C	ENST00000456743.1	+	1	470	c.432G>C	c.(430-432)atG>atC	p.M144I		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTGGACTTATGACTGCCTTTT	0.453000													74	250					0	0	1	0	0
ZRANB2	9406	broad.mit.edu	37	1	71544247	71544247	+	Splice_Site	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:71544247C>T	ENST00000370920.3	-	3	412	c.109_splice	c.e3-1	p.E37_splice	ZRANB2_ENST00000254821.6_Splice_Site_p.E37_splice	NM_203350.2	NP_976225.1	O95218	ZRAB2_HUMAN	zinc finger, RAN-binding domain containing 2	37					mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|stomach(1)	15						CAGTTGTTTTCTCTGAAAACA	0.373000													24	59					0	0	1	0	0
CD34	947	broad.mit.edu	37	1	208072511	208072511	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:208072511G>A	ENST00000356522.4	-	3	644	c.323C>T	c.(322-324)tCt>tTt	p.S108F	CD34_ENST00000310833.7_Missense_Mutation_p.S108F|CD34_ENST00000537704.1_Intron	NM_001773.2	NP_001764.1	P28906	CD34_HUMAN	CD34 molecule	108					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						CTGGACAGAAGAGTTTGTGTT	0.473000													54	184					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109367852	109367852	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:109367852C>T	ENST00000283195.6	+	10	1532	c.1406C>T	c.(1405-1407)tCa>tTa	p.S469L		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	469					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding	p.S469*(2)	RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						CATGAAACCTCAAGGCTTGAA	0.338000													11	229					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107400293	107400293	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chrX:107400293C>T	ENST00000334504.7	-	45	5243	c.5010G>A	c.(5008-5010)acG>acA	p.T1670T	COL4A6_ENST00000372216.4_Silent_p.T1671T|COL4A6_ENST00000418180.1_Silent_p.T205T|COL4A6_ENST00000394872.2_Silent_p.T1671T|COL4A6_ENST00000545689.1_Silent_p.T1646T|COL4A6_ENST00000538570.1_Silent_p.T1613T	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1671	Collagen IV NC1.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						CAGCTTTCAGCGTTTCAGACA	0.582000									Alport syndrome with Diffuse Leiomyomatosis				40	55					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458870	248458870	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:248458870C>T	ENST00000317996.1	-	1	10	c.11G>A	c.(10-12)aGa>aAa	p.R4K		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GGTAGTATTTCTCATCTCCAT	0.443000													19	116					0	0	1	0	0
CXorf21	80231	broad.mit.edu	37	X	30577888	30577888	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chrX:30577888C>T	ENST00000378962.3	-	3	907	c.585G>A	c.(583-585)gaG>gaA	p.E195E		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21	195										kidney(1)|large_intestine(3)|lung(13)|ovary(1)|stomach(1)|urinary_tract(1)	20						AGCTGCTTTTCTCTTTGATGC	0.413000													46	63					0	0	1	0	0
CCDC57	284001	broad.mit.edu	37	17	80159775	80159775	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:80159775G>A	ENST00000392347.1	-	2	82	c.46C>T	c.(46-48)Cgc>Tgc	p.R16C	CCDC57_ENST00000392343.3_Missense_Mutation_p.R16C|CCDC57_ENST00000389641.4_Missense_Mutation_p.R16C	NM_198082.2	NP_932348.2	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	16										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TCCTCCTTGCGAAGCAGCAGC	0.657000													3	32					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230658	36230658	+	Missense_Mutation	SNP	G	G	A	rs145147471	byFrequency	TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr4:36230658G>A	ENST00000303965.4	-	2	940	c.451C>T	c.(451-453)Cgc>Tgc	p.R151C		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	151					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GGGAAGTCGCGTTTAGGAGGA	0.393000													24	26					0	0	1	0	0
RBM27	54439	broad.mit.edu	37	5	145647224	145647224	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:145647224C>G	ENST00000265271.5	+	15	2510	c.2344C>G	c.(2344-2346)Cca>Gca	p.P782A	RBM27_ENST00000506502.1_Missense_Mutation_p.P727A	NM_018989.1	NP_061862.1	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	782					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding	p.P782A(1)		NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTTTCAACTCCAGGCCATCC	0.289000													15	54					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245849209	245849209	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:245849209C>G	ENST00000366518.4	+	9	1885	c.1781C>G	c.(1780-1782)tCt>tGt	p.S594C	KIF26B_ENST00000407071.2_Missense_Mutation_p.S975C			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	975	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGCCCACTCTCTGAGTCTGAT	0.577000													6	23					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718734	2718734	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:2718734G>A	ENST00000382082.3	+	1	1233	c.995G>A	c.(994-996)cGc>cAc	p.R332H		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	332						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		CGCTTCGCGCGCAGCGCCCTC	0.677000													41	62					0	0	1	0	0
MBP	4155	broad.mit.edu	37	18	74692412	74692412	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr18:74692412G>A	ENST00000355994.2	-	9	1149	c.886C>T	c.(886-888)Cgc>Tgc	p.R296C	MBP_ENST00000382582.3_Missense_Mutation_p.R189C|MBP_ENST00000397875.3_Missense_Mutation_p.R173C|MBP_ENST00000578193.1_3'UTR|MBP_ENST00000397866.4_Missense_Mutation_p.R163C|RP11-862L9.3_ENST00000582763.1_RNA|MBP_ENST00000580402.1_Missense_Mutation_p.R296C|MBP_ENST00000528160.1_Silent_p.V46V|MBP_ENST00000354542.4_Missense_Mutation_p.R65C|MBP_ENST00000526111.1_Missense_Mutation_p.R141C|MBP_ENST00000579129.1_Missense_Mutation_p.R245C|MBP_ENST00000397865.5_Missense_Mutation_p.R152C|MBP_ENST00000359645.3_Missense_Mutation_p.R178C|MBP_ENST00000527041.1_Intron|MBP_ENST00000397869.3_Missense_Mutation_p.R228C	NM_001025101.1	NP_001020272.1	P02686	MBP_HUMAN	myelin basic protein	296					central nervous system development|immune response|synaptic transmission	plasma membrane	structural constituent of myelin sheath			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.79e-06)|BRCA - Breast invasive adenocarcinoma(31;0.113)|READ - Rectum adenocarcinoma(1;0.188)		GATCCAGAGCGACTATCTCTT	0.527000													37	94					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121171	38121171	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr22:38121171C>G	ENST00000406386.3	+	7	2863	c.2608C>G	c.(2608-2610)Caa>Gaa	p.Q870E	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	870					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CTCCTCATCTCAATGCTGCAC	0.498000													59	154					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12385844	12385844	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:12385844C>T	ENST00000356109.5	-	4	397	c.279G>A	c.(277-279)atG>atA	p.M93I	ZNF44_ENST00000355684.5_Missense_Mutation_p.M45I	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	93	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		TTTCCCATTTCATTCCTAAAA	0.308000													3	16					0	0	1	0	0
FMOD	2331	broad.mit.edu	37	1	203316865	203316865	+	Silent	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:203316865C>G	ENST00000354955.4	-	2	997	c.534G>C	c.(532-534)ctG>ctC	p.L178L	FMOD_ENST00000464898.1_5'UTR	NM_002023.4	NP_002014.2	Q06828	FMOD_HUMAN	fibromodulin	178					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	17			BRCA - Breast invasive adenocarcinoma(75;0.171)			GGAGCTCTCTCAGGGATCGAG	0.597000													108	79					0	0	1	0	0
QSER1	79832	broad.mit.edu	37	11	32956885	32956885	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:32956885G>A	ENST00000399302.2	+	4	4029	c.3694G>A	c.(3694-3696)Gat>Aat	p.D1232N	QSER1_ENST00000527788.1_Missense_Mutation_p.D993N	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1232										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					ATTTTCTTCTGATGAAGATGA	0.353000													10	167					0	0	1	0	0
FCGR2A	2212	broad.mit.edu	37	1	161480645	161480645	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:161480645C>T	ENST00000271450.6	+	5	679	c.641C>T	c.(640-642)tCa>tTa	p.S214L	FCGR2A_ENST00000367972.4_Missense_Mutation_p.S213L|FCGR2A_ENST00000467525.1_3'UTR	NM_001136219.1|NM_021642.3	NP_001129691.1|NP_067674.2	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor (CD32)	214						integral to membrane|plasma membrane	IgG binding|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)	19	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGCAGCTCTTCACCAATGGGG	0.507000													40	152					0	0	1	0	0
ANKZF1	55139	broad.mit.edu	37	2	220098519	220098519	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:220098519C>T	ENST00000323348.5	+	8	1076	c.902C>T	c.(901-903)tCt>tTt	p.S301F	ANKZF1_ENST00000409849.1_Missense_Mutation_p.S91F|ANKZF1_ENST00000410034.3_Missense_Mutation_p.S301F	NM_018089.2	NP_060559.2	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing 1	301						intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	23		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTCCCCGCTCTGGCCGGTCT	0.602000													42	84					0	0	1	0	0
UPK3B	80761	broad.mit.edu	37	7	76140988	76140988	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr7:76140988C>G	ENST00000419923.2	+	2	640	c.415C>G	c.(415-417)Cag>Gag	p.Q139E	UPK3B_ENST00000257632.5_Missense_Mutation_p.Q139E|UPK3B_ENST00000394849.1_Missense_Mutation_p.Q84E|UPK3B_ENST00000334348.3_Missense_Mutation_p.Q84E|UPK3B_ENST00000448265.3_Missense_Mutation_p.Q139E|UPK3B_ENST00000443097.2_Missense_Mutation_p.Q84E			Q9BT76	UPK3B_HUMAN	uroplakin 3B	139					negative regulation of gene expression	integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(1)|skin(2)	8		Myeloproliferative disorder(862;0.204)				CAGGGGCTTCCAGAACCCGGA	0.622000													4	9					0	0	1	0	0
TNFRSF1B	7133	broad.mit.edu	37	1	12266899	12266899	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:12266899C>T	ENST00000376259.3	+	10	1297	c.1208C>T	c.(1207-1209)tCc>tTc	p.S403F	TNFRSF1B_ENST00000492361.1_3'UTR	NM_001066.2	NP_001057.1	P20333	TNR1B_HUMAN	tumor necrosis factor receptor superfamily, member 1B	403					apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(1)|liver(1)|lung(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	CAAGCCAGCTCCACAATGGGA	0.597000													28	48					0	0	1	0	0
XRRA1	143570	broad.mit.edu	37	11	74638504	74638504	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:74638504C>T	ENST00000340360.6	-	7	761	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	XRRA1_ENST00000527087.1_Missense_Mutation_p.E144K|XRRA1_ENST00000533598.1_5'UTR|XRRA1_ENST00000321448.8_5'UTR	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	144					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						AGATCCAGTTCCTTTAGGGCT	0.393000													8	17					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34828442	34828442	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr20:34828442G>C	ENST00000373932.3	+	2	998	c.652G>C	c.(652-654)Gag>Cag	p.E218Q	AAR2_ENST00000397286.3_Missense_Mutation_p.E218Q|AAR2_ENST00000320849.4_Missense_Mutation_p.E218Q	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		GATGTTCCCAGAGGGTGCCAC	0.602000													36	113					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340544	121340544	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr3:121340544G>A	ENST00000338040.4	+	3	682	c.268G>A	c.(268-270)Gcc>Acc	p.A90T		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	90					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GGTGTGCCCCGCCAGCGTGGT	0.577000													27	54					0	0	1	0	0
MGEA5	10724	broad.mit.edu	37	10	103557837	103557837	+	Silent	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr10:103557837G>C	ENST00000361464.3	-	10	2279	c.1884C>G	c.(1882-1884)ctC>ctG	p.L628L	MGEA5_ENST00000482611.1_5'UTR|MGEA5_ENST00000357797.5_Silent_p.L575L|MGEA5_ENST00000370094.3_Silent_p.L628L|MGEA5_ENST00000439817.1_Silent_p.L575L	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	628	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		CACAATTGGAGAGCCGAGTGA	0.403000													4	60					0	0	1	0	0
TUBB4A	10382	broad.mit.edu	37	19	6495551	6495551	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:6495551C>T	ENST00000264071.2	-	4	1330	c.959G>A	c.(958-960)cGc>cAc	p.R320H	TUBB4A_ENST00000540257.1_Missense_Mutation_p.R320H			P04350	TBB4_HUMAN	tubulin, beta 4A class IVa	320					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity										CATGGACATGCGGCCCCGGAA	0.637000													5	195					0	0	1	0	0
TOLLIP	54472	broad.mit.edu	37	11	1310007	1310007	+	Splice_Site	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:1310007C>T	ENST00000527886.1	-	4	540		c.e4-1		TOLLIP_ENST00000317204.6_Splice_Site|TOLLIP_ENST00000528719.1_Splice_Site|TOLLIP_ENST00000525159.1_Splice_Site|TOLLIP_ENST00000542915.1_Splice_Site|TOLLIP_ENST00000527938.1_Intron|TOLLIP_ENST00000263646.7_Splice_Site			Q9H0E2	TOLIP_HUMAN	toll interacting protein						cell-cell signaling|inflammatory response|innate immune response|intracellular signal transduction|leukocyte activation|phosphorylation	cytosol|interleukin-1 receptor complex|interleukin-18 receptor complex	kinase binding|signal transducer activity|Toll-like receptor binding			large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	6		all_cancers(49;7.62e-05)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00152)|Lung(200;0.09)|LUSC - Lung squamous cell carcinoma(625;0.107)		AGAAGGCTCTCTGCGGGAGAC	0.657000													19	21					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52548442	52548442	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr3:52548442G>A	ENST00000321725.6	+	34	3684	c.3608G>A	c.(3607-3609)cGg>cAg	p.R1203Q		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1203	FAS1 4.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GAAACCCTGCGGAAGGGTGGA	0.617000													5	56					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43314943	43314943	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:43314943G>A	ENST00000331495.3	+	9	1167	c.831G>A	c.(829-831)gcG>gcA	p.A277A	FMNL1_ENST00000328118.3_Silent_p.A277A|FMNL1_ENST00000592006.1_3'UTR	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	277	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						AGCTGCTGGCGGCCGTGTGCT	0.607000													55	124					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11850101	11850101	+	Missense_Mutation	SNP	C	C	T	rs150604583		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:11850101C>T	ENST00000396516.2	-	20	2751	c.2554G>A	c.(2554-2556)Gaa>Aaa	p.E852K	ZC3H7A_ENST00000575984.1_Missense_Mutation_p.E48K|ZC3H7A_ENST00000355758.4_Missense_Mutation_p.E852K			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	852						nucleus	nucleic acid binding|zinc ion binding	p.E852Q(1)		breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						ACTGTAACTTCAGCATAATCT	0.398000													40	82					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77921464	77921464	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:77921464C>T	ENST00000310924.2	-	9	1823	c.1708G>A	c.(1708-1710)Gag>Aag	p.E570K	TBC1D16_ENST00000572862.1_Missense_Mutation_p.E208K|TBC1D16_ENST00000570373.1_Missense_Mutation_p.E209K|TBC1D16_ENST00000576768.1_Missense_Mutation_p.E195K|TBC1D16_ENST00000340848.7_Missense_Mutation_p.E208K	NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	570	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			TCCATGTCCTCGTCCCGGGGT	0.612000													4	89					0	0	1	0	0
TLR1	7096	broad.mit.edu	37	4	38799112	38799112	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr4:38799112G>A	ENST00000308979.2	-	4	1614	c.1341C>T	c.(1339-1341)atC>atT	p.I447I	TLR1_ENST00000502213.2_Silent_p.I447I	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	447					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						CAAGTACCTTGATCCTGGGAG	0.318000													32	50					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43766890	43766890	+	Silent	SNP	T	T	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:43766890T>C	ENST00000263801.3	-	10	1398	c.1146A>G	c.(1144-1146)acA>acG	p.T382T	TP53BP1_ENST00000382039.3_Silent_p.T387T|TP53BP1_ENST00000382044.4_Silent_p.T387T|TP53BP1_ENST00000450115.2_Silent_p.T387T	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	382					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CTTCTTGCTCTGTGGGACTGC	0.423000								Other conserved DNA damage response genes					15	21					0	0	1	0	0
HIPK4	147746	broad.mit.edu	37	19	40889933	40889933	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:40889933G>A	ENST00000291823.2	-	2	863	c.579C>T	c.(577-579)tgC>tgT	p.C193C		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	193	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CCACCTTCTCGCAGAAGGGCA	0.632000													4	85					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	416876	416876	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:416876G>A	ENST00000399788.2	-	23	4036	c.3674C>T	c.(3673-3675)aCt>aTt	p.T1225I	KDM5A_ENST00000382815.4_Missense_Mutation_p.T1225I	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1225					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TGACAGAATAGTCTCTAGCCT	0.483000			T	NUP98	AML								4	62					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048161	6048161	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:6048161G>A	ENST00000316650.5	-	1	810	c.774C>T	c.(772-774)ttC>ttT	p.F258F		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTATGGTGCTGAAGAAAAGAA	0.507000													32	52					0	0	1	0	0
ZNF211	10520	broad.mit.edu	37	19	58152857	58152857	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:58152857C>T	ENST00000544273.1	+	5	1366	c.1039C>T	c.(1039-1041)Cac>Tac	p.H347Y	ZNF211_ENST00000420680.1_Missense_Mutation_p.H339Y|ZNF211_ENST00000240731.4_Missense_Mutation_p.H348Y|ZNF211_ENST00000391703.3_Missense_Mutation_p.H274Y|ZNF211_ENST00000347302.3_Missense_Mutation_p.H335Y|ZNF211_ENST00000299871.5_Missense_Mutation_p.H400Y|ZNF211_ENST00000254182.7_Missense_Mutation_p.H326Y|ZNF211_ENST00000541801.1_Missense_Mutation_p.H326Y			Q13398	ZN211_HUMAN	zinc finger protein 211	335						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TAGGAAAGTTCACACTGGAGA	0.458000													29	55					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5929142	5929142	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:5929142C>T	ENST00000399933.3	-	6	2399	c.2400G>A	c.(2398-2400)cgG>cgA	p.R800R	KIAA2026_ENST00000381461.2_Silent_p.R770R	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	800										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CAGCTTGCCTCCGATGATACC	0.299000													10	40					0	0	1	0	0
MFSD9	84804	broad.mit.edu	37	2	103340312	103340312	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:103340312C>G	ENST00000258436.5	-	5	527	c.484G>C	c.(484-486)Gag>Cag	p.E162Q		NM_032718.3	NP_116107.3	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing 9	162					transmembrane transport	integral to membrane|plasma membrane	transporter activity	p.E162K(1)		breast(3)|large_intestine(7)|liver(1)|lung(6)|ovary(2)|skin(1)	20						CGTTCCTTCTCTGGAACCACA	0.498000													23	63					0	0	1	0	0
ZBTB44	29068	broad.mit.edu	37	11	130131665	130131665	+	Missense_Mutation	SNP	A	A	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:130131665A>T	ENST00000525842.1	-	2	471	c.104T>A	c.(103-105)aTt>aAt	p.I35N	ZBTB44_ENST00000357899.4_Missense_Mutation_p.I35N|ZBTB44_ENST00000530205.1_Missense_Mutation_p.I35N|ZBTB44_ENST00000397753.1_Missense_Mutation_p.I35N	NM_014155.4	NP_054874.3	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	35	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		CTGGACACGAATAGTGATATC	0.448000													37	83					0	0	1	0	0
EIF4G2	1982	broad.mit.edu	37	11	10823929	10823929	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:10823929G>T	ENST00000526148.1	-	12	1560	c.1050C>A	c.(1048-1050)ttC>ttA	p.F350L	EIF4G2_ENST00000396525.2_Missense_Mutation_p.F350L|EIF4G2_ENST00000339995.5_Missense_Mutation_p.F350L|EIF4G2_ENST00000525681.1_Missense_Mutation_p.F350L	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	350					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CCTCCAGAAAGAAGTCACTTC	0.433000													51	100					4.25531e-23	4.54878e-23	1	1	0
OR4C13	283092	broad.mit.edu	37	11	49974168	49974168	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr11:49974168C>A	ENST00000555099.1	+	1	226	c.194C>A	c.(193-195)tCc>tAc	p.S65Y		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						GCCTATCTCTCCTTTATTGAT	0.428000													74	147					1.14856e-27	1.23385e-27	1	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178552067	178552067	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:178552067G>A	ENST00000251582.7	-	19	2966	c.2865C>T	c.(2863-2865)caC>caT	p.H955H		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	955	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGTGCTTGGCGTGCACGGAGC	0.692000													6	217					0	0	1	0	0
BBS5	129880	broad.mit.edu	37	2	170349481	170349481	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:170349481G>A	ENST00000295240.3	+	6	860	c.484G>A	c.(484-486)Gat>Aat	p.D162N	BBS5_ENST00000392663.2_Missense_Mutation_p.D162N|BBS5_ENST00000554017.1_Missense_Mutation_p.D162N|RP11-724O16.1_ENST00000513963.1_Missense_Mutation_p.D162N	NM_152384.2	NP_689597.1			Bardet-Biedl syndrome 5											endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						ACATGTATATGATAAAATAAA	0.328000									Bardet-Biedl syndrome				24	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087590	9087590	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:9087590C>G	ENST00000397910.4	-	1	4428	c.4225G>C	c.(4225-4227)Gag>Cag	p.E1409Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1409	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACTGTGTCTCAAATCCAGAT	0.473000													41	93					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52639288	52639288	+	Silent	SNP	C	C	T	rs138875857	byFrequency	TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:52639288C>T	ENST00000331817.5	+	7	1260	c.1077C>T	c.(1075-1077)gcC>gcT	p.A359A	KRT7_ENST00000552322.1_3'UTR|RP3-416H24.1_ENST00000546686.1_RNA	NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	359	Coil 2.|Rod.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		AGCTGGAAGCCGCCCTGCAGC	0.652000													26	63					0	0	1	0	0
BMP4	652	broad.mit.edu	37	14	54418948	54418948	+	Splice_Site	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr14:54418948C>T	ENST00000245451.4	-	3	387		c.e3-1		BMP4_ENST00000417573.1_Splice_Site|BMP4_ENST00000558984.1_Splice_Site|BMP4_ENST00000559087.1_Splice_Site	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4						activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						CATGGTGTCTCTGGGGAGGGG	0.468000													20	32					0	0	1	0	0
POLR3F	10621	broad.mit.edu	37	20	18448187	18448187	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr20:18448187G>A	ENST00000377603.4	+	1	417	c.37G>A	c.(37-39)Gcg>Acg	p.A13T	POLR3F_ENST00000462997.1_3'UTR	NM_006466.2	NP_006457.2	Q9H1D9	RPC6_HUMAN	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa	13					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|protein binding			breast(2)	2						GCCGCCTGACGCGGATCCGGT	0.632000													6	87					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50824598	50824598	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr10:50824598G>C	ENST00000395562.2	+	3	560	c.91G>C	c.(91-93)Gaa>Caa	p.E31Q	CHAT_ENST00000339797.1_5'UTR|CHAT_ENST00000337653.2_Missense_Mutation_p.E113Q|CHAT_ENST00000351556.3_5'UTR|CHAT_ENST00000460699.1_3'UTR|CHAT_ENST00000395559.2_5'UTR|CHAT_ENST00000455728.2_5'UTR	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	113					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GCCCATCCTGGAAAAGGTCCC	0.562000													3	17					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119148066	119148066	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr4:119148066G>A	ENST00000296499.5	+	8	2151	c.1748G>A	c.(1747-1749)aGa>aAa	p.R583K	NDST3_ENST00000433996.2_Missense_Mutation_p.R502K	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	583	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						AAACGCCACAGAGACATTTGG	0.368000													22	45					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131339461	131339461	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:131339461C>G	ENST00000372739.3	+	7	949	c.839C>G	c.(838-840)tCt>tGt	p.S280C	SPTAN1_ENST00000358161.5_Missense_Mutation_p.S280C|SPTAN1_ENST00000372731.4_Missense_Mutation_p.S280C	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	280					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						TTAATGGCCTCTGATGATTTT	0.483000													50	129					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44907628	44907628	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr15:44907628G>C	ENST00000261866.7	-	16	2987	c.2971C>G	c.(2971-2973)Caa>Gaa	p.Q991E	SPG11_ENST00000535302.2_Missense_Mutation_p.Q991E|SPG11_ENST00000427534.2_Missense_Mutation_p.Q991E|SPG11_ENST00000558319.1_Missense_Mutation_p.Q991E	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	991					cell death	cytosol|integral to membrane|nucleus	protein binding	p.Q991*(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AGAATGAATTGAGAATGGAAA	0.423000													5	58					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3254607	3254607	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:3254607G>A	ENST00000304646.2	+	1	361	c.361G>A	c.(361-363)Gac>Aac	p.D121N	AJ003147.9_ENST00000576468.1_RNA	NM_012360.1	NP_036492.1	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F, member 1	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(7)	11						GATGGCCTATGACCACTTTGT	0.507000													73	113					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364320	10364320	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:10364320G>A	ENST00000377093.4	+	21	3230	c.3077G>A	c.(3076-3078)aGa>aAa	p.R1026K	KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377083.1_Missense_Mutation_p.R1026K	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	619					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CAAGGAATGAGAAGTCAAGAT	0.453000													12	249					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573366	140573366	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:140573366G>C	ENST00000239446.4	+	1	1425	c.1241G>C	c.(1240-1242)aGa>aCa	p.R414T		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		414	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGAGATCAGAGCCGAGTAC	0.473000													5	159					0	0	1	0	0
KIAA0930	23313	broad.mit.edu	37	22	45595798	45595798	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr22:45595798G>A	ENST00000336156.4	-	8	1036	c.971C>T	c.(970-972)tCg>tTg	p.S324L	KIAA0930_ENST00000251993.7_Missense_Mutation_p.S329L|KIAA0930_ENST00000391627.2_Missense_Mutation_p.S290L|KIAA0930_ENST00000474515.1_5'UTR|KIAA0930_ENST00000443310.3_Missense_Mutation_p.S306L	NM_001009880.1	NP_001009880.1	Q6ICG6	K0930_HUMAN	KIAA0930	324							protein binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|urinary_tract(1)	15						GTCGTTGGCCGAGTGCGACTT	0.637000													31	70					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23760011	23760011	+	Silent	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:23760011C>T	ENST00000336689.3	-	21	2078	c.2034G>A	c.(2032-2034)caG>caA	p.Q678Q	ASAP3_ENST00000437606.2_Silent_p.Q669Q|ASAP3_ENST00000495646.1_Silent_p.Q182Q|ASAP3_ENST00000484906.1_5'UTR	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	678					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						AGGTCCCCGCCTGGGCCTGCT	0.592000													57	123					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156918889	156918889	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr5:156918889G>A	ENST00000257527.4	-	17	2018	c.1940C>T	c.(1939-1941)tCc>tTc	p.S647F	ADAM19_ENST00000394020.1_Missense_Mutation_p.S649F|ADAM19_ENST00000517905.1_Missense_Mutation_p.S647F|ADAM19_ENST00000430702.2_Missense_Mutation_p.S380F	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	647	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTCAAAGAAGGAGGTGTTCCT	0.547000													17	37					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62067397	62067397	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr2:62067397C>T	ENST00000404929.1	-	3	753	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K	FAM161A_ENST00000405894.3_Missense_Mutation_p.E248K	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	248					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TTCTTCTGTTCTCTTATCATC	0.368000													24	64					0	0	1	0	0
ZNF287	57336	broad.mit.edu	37	17	16455848	16455848	+	Silent	SNP	A	A	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:16455848A>G	ENST00000395824.1	-	6	2225	c.1608T>C	c.(1606-1608)taT>taC	p.Y536Y	ZNF287_ENST00000395825.3_Silent_p.Y536Y			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	529					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CATTGCATTTATATGGTTTCT	0.348000													36	45					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103410676	103410676	+	Silent	SNP	G	G	A			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr14:103410676G>A	ENST00000361246.2	-	30	4248	c.3960C>T	c.(3958-3960)atC>atT	p.I1320I		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1320	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CCGGAAGCTTGATGTCAAAGC	0.572000													14	20					0	0	1	0	0
C1orf35	79169	broad.mit.edu	37	1	228290723	228290723	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:228290723C>T	ENST00000272139.4	-	2	356	c.122G>A	c.(121-123)cGc>cAc	p.R41H	C1orf35_ENST00000472617.1_5'UTR	NM_024319.2	NP_077295.1	Q9BU76	MMTA2_HUMAN	chromosome 1 open reading frame 35	41										large_intestine(1)|lung(1)|skin(1)	3		Prostate(94;0.0488)				CTTCTGCCAGCGGCCTACCGG	0.761000													3	7					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135272732	135272732	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr7:135272732C>G	ENST00000285968.6	+	10	1491	c.1465C>G	c.(1465-1467)Caa>Gaa	p.Q489E	NUP205_ENST00000440390.2_Intron	NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	489					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						GCGGCCCCCTCAACGCCAGGT	0.453000													13	26					0	0	1	0	0
SDR9C7	121214	broad.mit.edu	37	12	57317815	57317815	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:57317815G>C	ENST00000293502.1	-	4	887	c.744C>G	c.(742-744)aaC>aaG	p.N248K		NM_148897.2	NP_683695.1	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C, member 7	248						cytoplasm	binding|oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)	7						CCTGCATTATGTTTTTTAACT	0.483000													15	25					0	0	1	0	0
TERF2	7014	broad.mit.edu	37	16	69404416	69404416	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:69404416G>T	ENST00000254942.3	-	5	826	c.810C>A	c.(808-810)caC>caA	p.H270Q	TERF2_ENST00000567296.2_Missense_Mutation_p.H270Q|TERF2_ENST00000603068.1_Missense_Mutation_p.H228Q|TERF2_ENST00000569611.2_5'UTR	NM_005652.3	NP_005643.2	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	228					age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			NS(2)|breast(1)|large_intestine(3)|lung(1)	7		Ovarian(137;0.101)				CGTCATCCAGGTGGCTCTCCA	0.517000													15	17					1.52009e-12	1.60907e-12	1	1	0
WASF2	10163	broad.mit.edu	37	1	27736222	27736222	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:27736222C>T	ENST00000430629.2	-	8	1518	c.1303G>A	c.(1303-1305)Gat>Aat	p.D435N	WASF2_ENST00000536657.1_Intron	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	435					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		CTACGGGCATCGCTCACGGCA	0.562000													4	74					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40490751	40490751	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr17:40490751C>T	ENST00000264657.5	-	6	860	c.548G>A	c.(547-549)gGa>gAa	p.G183E	STAT3_ENST00000389272.3_Missense_Mutation_p.G85E|STAT3_ENST00000404395.3_Missense_Mutation_p.G183E|STAT3_ENST00000588969.1_Missense_Mutation_p.G183E|STAT3_ENST00000585517.1_Missense_Mutation_p.G183E	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	183					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TCACTTGCCTCCTTGACTCTT	0.343000									Hyperimmunoglobulin E Recurrent Infection Syndrome				22	29					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2428982	2428982	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:2428982delA	ENST00000449969.1	+	16	2238	c.2077delA	c.(2077-2079)acfs	p.N693fs	PLCH2_ENST00000419816.2_Frame_Shift_Del_p.N720fs|PLCH2_ENST00000378488.3_Intron|PLCH2_ENST00000378486.3_Frame_Shift_Del_p.N720fs|PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000288766.5_Intron			O75038	PLCH2_HUMAN	phospholipase C, eta 2	720	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GCTGCAGCTGAACCGAGCCAA	0.642													2	4	---	---	---	---					
HEYL	26508	broad.mit.edu	37	1	40092420	40092420	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr1:40092420delC	ENST00000372852.3	-	5	1065	c.746delG	c.(745-747)ccfs	p.R249fs	HEYL_ENST00000535435.1_Frame_Shift_Del_p.R221fs	NM_014571.3	NP_055386.1	Q9NQ87	HEYL_HUMAN	hes-related family bHLH transcription factor with YRPW motif-like	249	Pro-rich.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTCTAGGGGGCGGGCCCTCCG	0.692													2	4	---	---	---	---					
LOC403323	403323	broad.mit.edu	37	9	66545704	66545704	+	RNA	DEL	C	C	-	rs12353356		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr9:66545704delC	ENST00000445604.2	-	0	669																											GAAAAAAAAACAAAGAAAGAA	0.373													3	3	---	---	---	---					
LOC101927058	101927058	broad.mit.edu	37	12	43018865	43018867	+	RNA	DEL	TTC	TTC	-			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr12:43018865_43018867delTTC	ENST00000550337.1	-	0	752																											ctcttcttctttcttcttcttct	0.453													2	4	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20138376	20138376	+	RNA	DEL	G	G	-	rs57620493		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr14:20138376delG	ENST00000548261.1	+	0	391																											ACAaaagaaagaaagaaagaa	0.388													3	4	---	---	---	---					
MAP3K9	4293	broad.mit.edu	37	14	71275774	71275776	+	In_Frame_Del	DEL	CCT	CCT	-	rs3832971		TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr14:71275774_71275776delCCT	ENST00000554752.2	-	1	112_114	c.113_115delAGG	c.(112-117)gcg>g	p.EA38del	MAP3K9_ENST00000381250.4_In_Frame_Del_p.EA38del|MAP3K9_ENST00000555993.2_In_Frame_Del_p.EA38del			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	38	Ala-rich.|Poly-Glu.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity	p.E38delE(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GCCGCCGCCGcctcctcctcctc	0.773													2	4	---	---	---	---					
ABCA17P	650655	broad.mit.edu	37	16	2475097	2475098	+	RNA	DEL	TC	TC	-			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr16:2475097_2475098delTC	ENST00000469908.1	+	0	3047					NR_003574.1																						GGTAActctgtctctctctctc	0.559													2	4	---	---	---	---					
NACC1	112939	broad.mit.edu	37	19	13246599	13246599	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IQ-A61I-01A-11D-A30E-08	TCGA-IQ-A61I-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe4a060a-a901-4c5a-aee3-829275162fb1	9409c484-c855-40cc-955d-49eecc0a065e	g.chr19:13246599delC	ENST00000292431.4	+	2	704	c.578delC	c.(577-579)gtfs	p.A193fs		NM_052876.3	NP_443108.1	Q96RE7	NACC1_HUMAN	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	193					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body				endometrium(3)|large_intestine(2)|lung(3)|skin(1)	9						CAGAAGGAGGCTGGGGGCGGC	0.701													2	4	---	---	---	---					
