Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GNA15	2769	broad.mit.edu	37	19	3151776	3151776	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:3151776G>A	ENST00000262958.3	+	4	815	c.557G>A	c.(556-558)cGc>cAc	p.R186H	AC005264.2_ENST00000587587.1_RNA	NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	186					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity	p.R186H(1)		large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		CTCCGCAGCCGCATGCCCACC	0.647000													4	164					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107979367	107979367	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr1:107979367G>A	ENST00000370068.1	+	7	2182	c.1336G>A	c.(1336-1338)Ggg>Agg	p.G446R	NTNG1_ENST00000542803.1_Missense_Mutation_p.G446R|NTNG1_ENST00000370061.3_Missense_Mutation_p.G412R|NTNG1_ENST00000370065.1_Intron|NTNG1_ENST00000370066.1_Intron|NTNG1_ENST00000370067.1_Intron|NTNG1_ENST00000370070.2_Intron|NTNG1_ENST00000370074.4_Intron|NTNG1_ENST00000370071.2_Intron|NTNG1_ENST00000370072.3_Intron|NTNG1_ENST00000370073.2_Missense_Mutation_p.G446R			Q9Y2I2	NTNG1_HUMAN	netrin G1	446	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		TGGAACAACAGGGCCTAAGTG	0.493000													9	44					0	0	1	0	0
METTL22	79091	broad.mit.edu	37	16	8722952	8722952	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr16:8722952G>A	ENST00000381920.3	+	3	757	c.499G>A	c.(499-501)Gat>Aat	p.D167N	METTL22_ENST00000561758.1_Missense_Mutation_p.D111N	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	167							methyltransferase activity			large_intestine(5)|lung(4)	9						CAGCCCGCACGATATCATCAG	0.542000													88	343					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12880670	12880670	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr2:12880670C>T	ENST00000155926.4	+	3	2201	c.782C>T	c.(781-783)tCc>tTc	p.S261F	TRIB2_ENST00000381465.2_Missense_Mutation_p.S125F	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	261	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GAACCCAGCTCCCTCTTCAGC	0.597000													11	47					0	0	1	0	0
VPREB1	7441	broad.mit.edu	37	22	22599470	22599470	+	Silent	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr22:22599470C>T	ENST00000403807.3	+	2	298	c.159C>T	c.(157-159)agC>agT	p.S53S	VPREB1_ENST00000302273.2_Silent_p.S52S			P12018	VPREB_HUMAN	pre-B lymphocyte 1	53	Complementarity-determining-1.|Ig-like V-type.				immune response	extracellular region	antigen binding|protein binding			large_intestine(1)|liver(1)|lung(6)|skin(1)	9	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		GTGTGTACAGCGTCTACTGGT	0.627000													24	111					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16514682	16514682	+	Silent	SNP	G	G	A	rs76985523	byFrequency	TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:16514682G>A	ENST00000602009.1	-	9	1921	c.1026C>T	c.(1024-1026)gaC>gaT	p.D342D	EPS15L1_ENST00000594975.1_Silent_p.D496D|EPS15L1_ENST00000597937.1_Silent_p.D496D|EPS15L1_ENST00000535753.2_Silent_p.D496D|EPS15L1_ENST00000455140.2_Silent_p.D496D|EPS15L1_ENST00000248070.6_Silent_p.D496D			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	496	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						GGTTCAGATCGTCTTCCTGGG	0.478000													4	56					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30729917	30729917	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr3:30729917G>T	ENST00000295754.5	+	6	1820	c.1438G>T	c.(1438-1440)Gag>Tag	p.E480*	TGFBR2_ENST00000359013.4_Nonsense_Mutation_p.E505*	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	480	Protein kinase.				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						CAAGGTGCGGGAGCACCCCTG	0.507000													31	83					6.00712e-18	6.67458e-18	1	1	0
TOX3	27324	broad.mit.edu	37	16	52484404	52484404	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr16:52484404G>A	ENST00000219746.9	-	4	747	c.463C>T	c.(463-465)Cgg>Tgg	p.R155W	TOX3_ENST00000407228.3_Missense_Mutation_p.R150W	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	155					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity	p.R155W(1)|p.R150W(1)		NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						ACGATGGACCGCATGATCAGG	0.562000													5	122					0	0	1	0	0
PRKAR1B	5575	broad.mit.edu	37	7	618913	618913	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr7:618913C>T	ENST00000406797.1	-	9	1045	c.871G>A	c.(871-873)Gac>Aac	p.D291N	PRKAR1B_ENST00000403562.1_Missense_Mutation_p.D291N|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.D291N|PRKAR1B_ENST00000537384.1_Missense_Mutation_p.D291N|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.D291N	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	291					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		ATGTAAAAGTCGTCCCCAGGC	0.602000													44	152					0	0	1	0	0
PTGDR	5729	broad.mit.edu	37	14	52734574	52734574	+	Silent	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr14:52734574G>A	ENST00000306051.2	+	1	144	c.42G>A	c.(40-42)gtG>gtA	p.V14V	PTGDR_ENST00000553372.1_Silent_p.V14V	NM_000953.2	NP_000944.1	Q13258	PD2R_HUMAN	prostaglandin D2 receptor (DP)	14						integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CCACCTCTGTGGAAAAAGGCA	0.701000													10	16					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270859	1270859	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr16:1270859G>T	ENST00000348261.5	+	35	7175	c.6927G>T	c.(6925-6927)gaG>gaT	p.E2309D	CACNA1H_ENST00000358590.4_Missense_Mutation_p.E2303D|CACNA1H_ENST00000565831.1_Missense_Mutation_p.E2303D	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2309					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CAGAATCAGAGCCTCCCATGC	0.632000													42	143					1.02067e-35	1.16648e-35	1	1	0
PLIN5	440503	broad.mit.edu	37	19	4523694	4523694	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:4523694G>A	ENST00000381848.3	-	8	1318	c.1238C>T	c.(1237-1239)cCg>cTg	p.P413L		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	413						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CTGCTGGGCCGGCCAGTCCAG	0.706000													47	180					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62316042	62316042	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr15:62316042G>A	ENST00000261517.5	-	7	524	c.451C>T	c.(451-453)Cgt>Tgt	p.R151C	VPS13C_ENST00000249837.3_Intron|VPS13C_ENST00000395898.3_Intron|VPS13C_ENST00000395896.4_Missense_Mutation_p.R151C	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	151	Lys-rich.				protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TTACGTTTACGTCCTTCACAG	0.328000													6	47					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10428832	10428832	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr17:10428832C>G	ENST00000245503.5	-	32	4857	c.4473G>C	c.(4471-4473)aaG>aaC	p.K1491N	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.K1491N	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1491					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CATAGGCATTCTTTATCTTGA	0.443000													7	96					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579311	7579311	+	Splice_Site	SNP	C	C	A	rs68140816		TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr17:7579311C>A	ENST00000420246.2	-	4	508		c.e4+1		TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000359597.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(26)|p.0?(8)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGCAACTGACCGTGCAAGTC	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	69					6.45866e-13	6.88924e-13	1	1	0
POLR2J4	84820	broad.mit.edu	37	7	44005468	44005468	+	RNA	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr7:44005468G>A	ENST00000427076.1	-	0	1424					NR_003655.2																						GCACTTACTCGTCATGCTGCC	0.667000													8	23					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801135	67801135	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr13:67801135C>A	ENST00000544246.1	-	2	2129	c.1438G>T	c.(1438-1440)Gaa>Taa	p.E480*	PCDH9_ENST00000456367.1_Nonsense_Mutation_p.E480*|PCDH9_ENST00000377865.2_Nonsense_Mutation_p.E480*|PCDH9_ENST00000377861.3_Nonsense_Mutation_p.E480*|PCDH9_ENST00000328454.5_Nonsense_Mutation_p.E480*	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	480	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CGGTTGTTTTCAGAAACTGAC	0.433000													20	73					5.26018e-13	5.68668e-13	1	1	0
PLXNA4	91584	broad.mit.edu	37	7	131883335	131883335	+	Silent	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr7:131883335G>A	ENST00000359827.3	-	13	3609	c.2647C>T	c.(2647-2649)Ctg>Ttg	p.L883L	PLXNA4_ENST00000321063.4_Silent_p.L883L			Q9HCM2	PLXA4_HUMAN	plexin A4	883	IPT/TIG 1.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCCAGGCCCAGGTTCTCCCCT	0.542000													17	54					0	0	1	0	0
DARS2	55157	broad.mit.edu	37	1	173822554	173822554	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr1:173822554G>A	ENST00000361951.4	+	14	2139	c.1412G>A	c.(1411-1413)cGt>cAt	p.R471H	DARS2_ENST00000239457.5_Missense_Mutation_p.R53H|DARS2_ENST00000471476.1_3'UTR	NM_018122.4	NP_060592.2	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	471					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			breast(4)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	30					L-Aspartic Acid(DB00128)	GTGGTGCTCCGTGACCCCACT	0.478000													28	139					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2946453	2946453	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr7:2946453G>A	ENST00000396946.4	-	25	3687	c.3284C>T	c.(3283-3285)aCg>aTg	p.T1095M		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1095	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CTCCTCCTCCGTCTCAGGTCG	0.682000			Mis		DLBCL								15	25					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204171	56204171	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr18:56204171G>T	ENST00000361673.3	-	5	3461	c.3248C>A	c.(3247-3249)cCa>cAa	p.P1083Q	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1083							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GACATGGTGTGGGACTCCTGG	0.493000													37	144					6.02846e-25	6.79263e-25	1	1	0
CELSR1	9620	broad.mit.edu	37	22	46790148	46790148	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr22:46790148G>A	ENST00000262738.3	-	14	5854	c.5855C>T	c.(5854-5856)cCg>cTg	p.P1952L		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1952	EGF-like 7; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCTGGGGCACGGAAGGTCGAG	0.562000													3	48					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91134209	91134209	+	Silent	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chrX:91134209C>T	ENST00000373094.1	+	2	3815	c.2970C>T	c.(2968-2970)agC>agT	p.S990S	PCDH11X_ENST00000361724.1_Silent_p.S990S|PCDH11X_ENST00000361655.2_Silent_p.S990S|PCDH11X_ENST00000298274.8_Silent_p.S990S|PCDH11X_ENST00000373088.1_Silent_p.S990S|PCDH11X_ENST00000406881.1_Silent_p.S990S|PCDH11X_ENST00000395337.2_Silent_p.S990S|PCDH11X_ENST00000373097.1_Silent_p.S990S|PCDH11X_ENST00000504220.1_Silent_p.S990S	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	990					homophilic cell adhesion	integral to plasma membrane	calcium ion binding	p.S990S(2)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						ATCCCTACAGCGTTTCTGACT	0.478000													40	65					0	0	1	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72954808	72954808	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr15:72954808C>T	ENST00000421285.3	+	11	1063	c.1063C>T	c.(1063-1065)Cgg>Tgg	p.R355W		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	355										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						GCAGAGAGTGCGGGAGCAGGA	0.567000													5	405					0	0	1	0	0
COQ6	51004	broad.mit.edu	37	14	74426211	74426211	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr14:74426211G>A	ENST00000334571.2	+	8	917	c.877G>A	c.(877-879)Gtt>Att	p.V293I	COQ6_ENST00000238709.4_Missense_Mutation_p.V218I|ENTPD5_ENST00000557325.1_3'UTR|COQ6_ENST00000554920.1_Intron|COQ6_ENST00000394026.4_Missense_Mutation_p.V268I|COQ6_ENST00000557780.1_3'UTR	NM_182476.2	NP_872282.1	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	293					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		TGTGGATGCCGTTAACTCTGC	0.448000													4	170					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133917079	133917079	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr9:133917079C>T	ENST00000361069.4	+	7	1472	c.1339C>T	c.(1339-1341)Cgc>Tgc	p.R447C	LAMC3_ENST00000480883.1_3'UTR	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	447	Laminin EGF-like 4.				cell adhesion	basement membrane|membrane	structural molecule activity	p.R447C(2)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CCGCAGTGGGCGCTGCCCCTG	0.547000													12	30					0	0	1	0	0
FAM64A	54478	broad.mit.edu	37	17	6350972	6350972	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr17:6350972C>T	ENST00000572447.1	+	3	593	c.484C>T	c.(484-486)Cgc>Tgc	p.R162C	FAM64A_ENST00000576056.1_Missense_Mutation_p.R162C|FAM64A_ENST00000571373.1_Missense_Mutation_p.R162C|FAM64A_ENST00000250056.8_Missense_Mutation_p.R162C|FAM64A_ENST00000572595.2_Missense_Mutation_p.R193C|FAM64A_ENST00000570337.2_Missense_Mutation_p.R162C	NM_019013.2	NP_061886.2	Q9BSJ6	FA64A_HUMAN	family with sequence similarity 64, member A	162						nucleolus	protein binding			breast(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				COAD - Colon adenocarcinoma(228;0.141)		GGAGCATCACCGCCTCTCTGT	0.657000													3	24					0	0	1	0	0
RELT	84957	broad.mit.edu	37	11	73105607	73105607	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr11:73105607G>A	ENST00000064780.2	+	9	1135	c.874G>A	c.(874-876)Ggc>Agc	p.G292S	RELT_ENST00000393580.2_Missense_Mutation_p.G292S	NM_152222.1	NP_689408.1	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor	292						cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	12						CTCGCTCTCTGGCCCCTGCTG	0.682000													13	177					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44078907	44078907	+	Silent	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr2:44078907C>T	ENST00000272286.2	+	4	597	c.507C>T	c.(505-507)ttC>ttT	p.F169F		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	169	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CCTTGGCCTTCATTGCCCAGA	0.617000													5	186					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98188962	98188962	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr3:98188962T>C	ENST00000332650.5	+	1	639	c.542T>C	c.(541-543)aTt>aCt	p.I181T		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TACTGTGATATTCTTCCCTTG	0.388000													52	168					0	0	1	0	0
GORASP1	64689	broad.mit.edu	37	3	39142261	39142261	+	Silent	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr3:39142261G>A	ENST00000319283.3	-	5	1364	c.543C>T	c.(541-543)aaC>aaT	p.N181N	GORASP1_ENST00000479927.1_Silent_p.N86N|GORASP1_ENST00000422110.2_Intron	NM_031899.2	NP_114105.1	Q9BQQ3	GORS1_HUMAN	golgi reassembly stacking protein 1, 65kDa	181					mitotic prophase|protein transport	cytosol|Golgi apparatus|membrane				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(1)|ovary(3)|urinary_tract(1)	14				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CCCAGGCTGCGTTGGGAGTTA	0.582000											OREG0015486	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	179					0	0	1	0	0
DOK3	79930	broad.mit.edu	37	5	176935363	176935363	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr5:176935363C>T	ENST00000312943.6	-	3	407	c.247G>A	c.(247-249)Gct>Act	p.A83T	DOK3_ENST00000357198.4_Missense_Mutation_p.A139T|DOK3_ENST00000377112.4_Intron|DOK3_ENST00000501403.2_Missense_Mutation_p.A83T	NM_001144875.1	NP_001138347.1	Q7L591	DOK3_HUMAN	docking protein 3	139	PH.					cytoplasm|plasma membrane	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|lung(7)	13	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TCGCCGTCAGCCGGCAGCACG	0.711000													3	29					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29268247	29268247	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr2:29268247C>T	ENST00000379558.4	+	19	3044	c.2693C>T	c.(2692-2694)gCg>gTg	p.A898V	FAM179A_ENST00000403861.2_Missense_Mutation_p.A843V|FAM179A_ENST00000465300.1_3'UTR	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	898							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGTGGCCGTGCGGTGCTGGAT	0.607000													4	110					0	0	1	0	0
C6orf118	168090	broad.mit.edu	37	6	165715617	165715617	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr6:165715617T>C	ENST00000230301.8	-	2	214	c.194A>G	c.(193-195)aAc>aGc	p.N65S	C6orf118_ENST00000543069.1_5'UTR	NM_144980.3	NP_659417.2	Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	65										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CTTGTTGGGGTTCAGGTGTCC	0.592000													27	122					0	0	1	0	0
C12orf60	144608	broad.mit.edu	37	12	14976229	14976229	+	Silent	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr12:14976229G>A	ENST00000330828.2	+	2	564	c.360G>A	c.(358-360)acG>acA	p.T120T	C12orf60_ENST00000527783.1_Intron	NM_175874.3	NP_787070.2	Q5U649	CL060_HUMAN	chromosome 12 open reading frame 60	120										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	9						GTGCCCATACGCCAGTCATCA	0.428000													26	104					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287770	16287770	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr22:16287770C>T	ENST00000343518.6	-	1	167	c.116G>A	c.(115-117)gGc>gAc	p.G39D		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	39										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						GTTGCTCTTGCCGCTCCCCCT	0.592000													6	682					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39225527	39225527	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr3:39225527C>T	ENST00000340369.3	-	2	5638	c.5410G>A	c.(5410-5412)Ggg>Agg	p.G1804R	XIRP1_ENST00000421646.1_Missense_Mutation_p.G487R|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1804	Interaction with FLNC.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GCGTGGAGCCCGAGGTGGGAG	0.612000													24	78					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152500621	152500621	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr2:152500621C>T	ENST00000397345.3	-	57	7869	c.7667G>A	c.(7666-7668)cGc>cAc	p.R2556H	NEB_ENST00000409198.1_Missense_Mutation_p.R2556H|NEB_ENST00000172853.10_Missense_Mutation_p.R2556H|NEB_ENST00000427231.2_Missense_Mutation_p.R2556H|NEB_ENST00000603639.1_Missense_Mutation_p.R2556H|NEB_ENST00000604864.1_Missense_Mutation_p.R2556H	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	2556					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GAGCTGCTTGCGAAAGCCTTC	0.453000													66	261					0	0	1	0	0
FEZF2	55079	broad.mit.edu	37	3	62356914	62356914	+	Silent	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr3:62356914G>A	ENST00000283268.3	-	4	1392	c.1098C>T	c.(1096-1098)tgC>tgT	p.C366C	FEZF2_ENST00000486811.1_Silent_p.C366C|FEZF2_ENST00000475839.1_Silent_p.C366C	NM_018008.3	NP_060478.3	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	366					transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|lung(8)|skin(1)	20		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		AGCCTTTGCCGCAAAATTCGC	0.572000													4	88					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10094266	10094266	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chrX:10094266G>A	ENST00000380861.4	+	15	2417	c.2026G>A	c.(2026-2028)Gtg>Atg	p.V676M	WWC3_ENST00000454666.1_Missense_Mutation_p.V676M	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	676	C2.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						CAGAATCCCCGTGCATTCCAG	0.562000													4	165					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57180310	57180310	+	Silent	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr4:57180310G>A	ENST00000504228.1	+	6	747	c.642G>A	c.(640-642)ccG>ccA	p.P214P	KIAA1211_ENST00000264229.6_Silent_p.P214P|KIAA1211_ENST00000541073.1_Silent_p.P207P			Q6ZU35	K1211_HUMAN	KIAA1211	214	Glu-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					AACCCAATCCGCTGGATTCCG	0.602000													12	20					0	0	1	0	0
SLC9A6	10479	broad.mit.edu	37	X	135095108	135095108	+	Splice_Site	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chrX:135095108G>A	ENST00000370695.4	+	8	1077	c.1041_splice	c.e8-1	p.V348_splice	SLC9A6_ENST00000370698.3_Splice_Site_p.V316_splice|SLC9A6_ENST00000370701.1_Splice_Site_p.V296_splice	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	316					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					ACAGTCTTACGTGACAAAGTT	0.423000													4	109					0	0	1	0	0
STK24	8428	broad.mit.edu	37	13	99171637	99171637	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr13:99171637G>A	ENST00000397517.2	-	2	209	c.133C>T	c.(133-135)Cgg>Tgg	p.R45W	STK24_ENST00000481288.1_5'UTR|STK24_ENST00000539966.1_Missense_Mutation_p.R45W|STK24_ENST00000376547.3_Missense_Mutation_p.R57W	NM_001032296.2	NP_001027467.2	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24	57	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TTCTGAGTCCGATTGTCAATG	0.428000													5	245					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85383935	85383935	+	Silent	SNP	T	T	G			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr15:85383935T>G	ENST00000258888.5	+	5	2198	c.2031T>G	c.(2029-2031)acT>acG	p.T677T		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	677					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCCAGCCGACTAGGCCTTTCA	0.607000													13	74					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103359213	103359213	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr8:103359213C>T	ENST00000520539.1	-	6	1100	c.494G>A	c.(493-495)cGg>cAg	p.R165Q	UBR5_ENST00000220959.4_Missense_Mutation_p.R165Q|UBR5_ENST00000521922.1_Missense_Mutation_p.R165Q	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	165					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CCCTCGATCCCGTCCTGTCCG	0.557000													4	183					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26887335	26887335	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr1:26887335C>T	ENST00000374168.2	+	15	1488	c.1334C>T	c.(1333-1335)gCt>gTt	p.A445V	RPS6KA1_ENST00000530003.1_Missense_Mutation_p.A429V|RPS6KA1_ENST00000526792.1_Missense_Mutation_p.A353V|RPS6KA1_ENST00000374162.2_Missense_Mutation_p.A353V|RPS6KA1_ENST00000374166.4_Missense_Mutation_p.A434V|RPS6KA1_ENST00000531382.1_Missense_Mutation_p.A454V	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	445	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		ATGGAGTATGCTGTCAAGGTG	0.592000													4	94					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102449821	102449821	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr11:102449821C>T	ENST00000260228.2	-	9	1312	c.1300G>A	c.(1300-1302)Gaa>Aaa	p.E434K		NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	434	Hemopexin-like 3.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GAAAATTCTTCTTCAGTATTC	0.299000													40	54					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73151480	73151480	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr9:73151480G>T	ENST00000377110.2	-	25	4756	c.4513C>A	c.(4513-4515)Cta>Ata	p.L1505I	TRPM3_ENST00000423814.3_Missense_Mutation_p.L1532I|TRPM3_ENST00000358082.3_Missense_Mutation_p.L1367I|TRPM3_ENST00000377105.1_Missense_Mutation_p.L1364I|TRPM3_ENST00000408909.2_Missense_Mutation_p.L1364I|TRPM3_ENST00000396280.5_Missense_Mutation_p.L1354I|TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000396285.1_Missense_Mutation_p.L1364I|TRPM3_ENST00000360823.2_Missense_Mutation_p.L1367I|TRPM3_ENST00000396292.4_Missense_Mutation_p.L1377I|TRPM3_ENST00000377106.1_Missense_Mutation_p.L1377I|TRPM3_ENST00000357533.2_Missense_Mutation_p.L1509I	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1530						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GTGGTGGCTAGGTAGCGGCTA	0.498000													9	84					0.000673444	0.000681969	1	1	0
DNAH8	1769	broad.mit.edu	37	6	38840417	38840417	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr6:38840417G>A	ENST00000359357.3	+	48	6699	c.6445G>A	c.(6445-6447)Gga>Aga	p.G2149R	DNAH8_ENST00000449981.2_Missense_Mutation_p.G2366R|DNAH8_ENST00000441566.1_Missense_Mutation_p.G2113R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AACAGAATGCGGAAGGCCTCA	0.483000													15	70					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39788394	39788394	+	Silent	SNP	G	G	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr20:39788394G>T	ENST00000373272.2	+	2	771	c.366G>T	c.(364-366)ctG>ctT	p.L122L	PLCG1_ENST00000244007.3_Silent_p.L122L|PLCG1_ENST00000373271.1_Silent_p.L122L	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	122	PH 1.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				CGCTGAGCCTGCAAGGTGGGA	0.542000													16	103					2.23348e-06	2.3205e-06	1	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140798045	140798045	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr5:140798045G>A	ENST00000398594.2	+	1	619	c.619G>A	c.(619-621)Gct>Act	p.A207T	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCAGAGCGCTCACCACTT	0.498000													39	52					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242815330	242815330	+	Silent	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr2:242815330C>T	ENST00000343216.3	+	2	1651	c.1623C>T	c.(1621-1623)taC>taT	p.Y541Y		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	541						integral to membrane											CCGAGCCCTACGAGGACTTCT	0.667000													49	218					0	0	1	0	0
SMN2	6607	broad.mit.edu	37	5	69372363	69372363	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr5:69372363C>A	ENST00000380743.4	+	8	924	c.850C>A	c.(850-852)Caa>Aaa	p.Q284K	SMN2_ENST00000511812.1_Missense_Mutation_p.Q217K|SMN2_ENST00000380742.4_Missense_Mutation_p.Q252K|SMN2_ENST00000380741.4_Intron	NM_017411.3	NP_059107.1	Q16637	SMN_HUMAN	survival of motor neuron 2, centromeric	284	Required for interaction with SYNCRIP.				cell death|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding|RNA binding						Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TAGACAAAATCAAAAAGAAGG	0.284000													3	11					0.0215528	0.0215528	1	1	0
CBFA2T3	863	broad.mit.edu	37	16	88945792	88945792	+	Silent	SNP	C	C	A	rs141897085	by1000genomes	TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr16:88945792C>A	ENST00000268679.4	-	11	1944	c.1548G>T	c.(1546-1548)gcG>gcT	p.A516A	CBFA2T3_ENST00000327483.5_Silent_p.A430A|CBFA2T3_ENST00000436887.2_Silent_p.A478A|CBFA2T3_ENST00000448839.1_Silent_p.A440A|CBFA2T3_ENST00000360302.2_Silent_p.A430A	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	516					cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		TGAGCTCGTGCGCTTTGCGCT	0.662000			T	RUNX1	AML								6	69					5.9392e-07	6.25179e-07	1	1	0
PPL	5493	broad.mit.edu	37	16	4934643	4934643	+	Missense_Mutation	SNP	C	C	T	rs150735451	by1000genomes	TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr16:4934643C>T	ENST00000345988.2	-	22	4102	c.4013G>A	c.(4012-4014)cGg>cAg	p.R1338Q	PPL_ENST00000590782.2_Missense_Mutation_p.R1336Q	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1338					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						CTCCTCTTTCCGGGCGATCTG	0.607000													5	451					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98188932	98188932	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr3:98188932C>T	ENST00000332650.5	+	1	609	c.512C>T	c.(511-513)tCg>tTg	p.S171L		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S171L(1)		breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTCTGTGGATCGAATCACATC	0.398000													35	190					0	0	1	0	0
C17orf82	388407	broad.mit.edu	37	17	59489575	59489575	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr17:59489575C>G	ENST00000335108.2	+	1	464	c.239C>G	c.(238-240)cCg>cGg	p.P80R		NM_203425.1	NP_982249.1	Q86X59	CQ082_HUMAN	chromosome 17 open reading frame 82	80										cervix(1)|lung(1)	2						GGAGGAAGCCCGAGCTCCGGG	0.746000											OREG0024630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	13					0	0	1	0	0
FEZF2	55079	broad.mit.edu	37	3	62355884	62355884	+	Silent	SNP	C	C	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr3:62355884C>T	ENST00000283268.3	-	5	1548	c.1254G>A	c.(1252-1254)acG>acA	p.T418T	FEZF2_ENST00000486811.1_Silent_p.T418T|FEZF2_ENST00000475839.1_Silent_p.T418T	NM_018008.3	NP_060478.3	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	418					transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|lung(8)|skin(1)	20		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		AAGTGGCGCACGTGAAAGGCT	0.527000													4	192					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55361943	55361943	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:55361943G>A	ENST00000326321.3	+	1	46	c.13G>A	c.(13-15)Gtc>Atc	p.V5I	KIR3DL1_ENST00000402254.2_Intron|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.V5I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	5					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		GTCGCTCACGGTCGTCAGCAT	0.607000													27	59					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43766196	43766196	+	Silent	SNP	G	G	A	rs150952802		TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:43766196G>A	ENST00000244293.7	-	3	591	c.525C>T	c.(523-525)gaC>gaT	p.D175D	PSG9_ENST00000593948.1_Silent_p.D175D|PSG9_ENST00000443718.3_Intron|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000270077.3_Silent_p.D175D			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	175	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				GGTAGCTTGCGTCCAGAGTCT	0.532000													5	403					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157111	22157111	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:22157111G>T	ENST00000397126.4	-	4	873	c.725C>A	c.(724-726)tCa>tAa	p.S242*	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGTAAGGATTGAGAACTTACT	0.368000													11	53					3.03607e-14	3.3272e-14	1	1	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	G	A	rs143435240	byFrequency	TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chrX:51076024G>A	ENST00000376006.3	+	2	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_ENST00000356450.2_Silent_p.E69E	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(8)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000													3	35					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2732937	2732937	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:2732937C>A	ENST00000269740.4	-	3	1086	c.757G>T	c.(757-759)Gcc>Tcc	p.A253S	SLC39A3_ENST00000545664.1_Missense_Mutation_p.A253S|AC006538.4_ENST00000586572.1_Intron	NM_144564.4	NP_653165.2	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	253						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCCCTGGGCGCTCTCAATG	0.711000													8	68					0.000157383	0.000161419	1	1	0
SNHG12	85028	broad.mit.edu	37	1	28906820	28906820	+	RNA	DEL	A	A	-	rs11325748		TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr1:28906820delA	ENST00000488745.1	-	0	1100				SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000475441.1_RNA																							actccgtctcaaaaaaaaaaa	0.493													3	4	---	---	---	---					
RPTN	126638	broad.mit.edu	37	1	152128277	152128280	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr1:152128277_152128280delTGTC	ENST00000316073.3	-	3	1359_1362	c.1295_1298delGACA	c.(1294-1299)aafs	p.RQ432fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	432	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding	p.R432K(1)		breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						ACTCTGGCCTTGTCTGTCTGTCTG	0.525													7	1288	---	---	---	---					
MBD5	55777	broad.mit.edu	37	2	149247884	149247886	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr2:149247884_149247886delTCT	ENST00000407073.1	+	12	4981_4983	c.3984_3986delTCT	c.(3982-3987)tcg>tc	p.SL1328del	MBD5_ENST00000404807.1_In_Frame_Del_p.SL1561del	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1328						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TGGAAAATTCTCTGGTCAAAGAC	0.448													11	56	---	---	---	---					
PMS2CL	441194	broad.mit.edu	37	7	6761577	6761578	+	RNA	INS	-	-	CCT			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr7:6761577_6761578insCCT	ENST00000486256.1	+	0	346					NR_002217.1																						ATCATCCACCACCTCCTGGAGG	0.589													2	4	---	---	---	---					
RP11-428C19.4	0	broad.mit.edu	37	11	19296063	19296063	+	RNA	DEL	A	A	-	rs111431546		TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr11:19296063delA	ENST00000527978.1	+	0	339																											actctgtttcaaaaaaaaaaa	0.478													3	5	---	---	---	---					
CDK2AP2	10263	broad.mit.edu	37	11	67275483	67275483	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr11:67275483delG	ENST00000301488.3	-	1	619	c.71delC	c.(70-72)cgfs	p.P24fs	CDK2AP2_ENST00000531506.1_Frame_Shift_Del_p.P24fs	NM_005851.3	NP_005842.1	O75956	CDKA2_HUMAN	cyclin-dependent kinase 2 associated protein 2	24										lung(1)	1						TGTAGGGACCGGGGTGCCCGG	0.692													2	4	---	---	---	---					
LOC101928823	101928823	broad.mit.edu	37	11	112332121	112332121	+	RNA	DEL	T	T	-			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr11:112332121delT	ENST00000528496.1	+	0	231																											TGATTTTATGTTTTTTTTTTT	0.378													2	4	---	---	---	---					
HERC2P9	440248	broad.mit.edu	37	15	28913366	28913367	+	RNA	INS	-	-	T			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr15:28913366_28913367insT	ENST00000528584.1	+	0	1224					NR_036443.1																						TTGAGTTCTCCTTTTTTTTTTT	0.307													3	4	---	---	---	---					
LILRB2	10288	broad.mit.edu	37	19	54780707	54780709	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chr19:54780707_54780709delGAG	ENST00000391748.1	-	10	1559_1561	c.1432_1434delCTC	c.(1432-1434)del	p.L478del	LILRB2_ENST00000314446.5_In_Frame_Del_p.L478del|LILRB2_ENST00000391746.1_In_Frame_Del_p.L479del|LILRB2_ENST00000391749.4_In_Frame_Del_p.L479del|LILRB2_ENST00000434421.1_In_Frame_Del_p.L363del	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	479					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.L479L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggatgaggaagaggaggaggagg	0.611													7	197	---	---	---	---					
FLNA	2316	broad.mit.edu	37	X	153594745	153594745	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IQ-A61J-01A-11D-A30E-08	TCGA-IQ-A61J-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fe4298f-82f3-4228-bfa4-d937a7efc4ff	ab7abe4d-2eb2-4598-bdf9-0f2604b148aa	g.chrX:153594745delG	ENST00000422373.1	-	8	1407	c.1159delC	c.(1159-1161)aafs	p.Q387fs	FLNA_ENST00000369850.3_Frame_Shift_Del_p.Q387fs|FLNA_ENST00000344736.4_Frame_Shift_Del_p.Q387fs|FLNA_ENST00000360319.4_Frame_Shift_Del_p.Q387fs	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	387					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCGGGACCTTGGGCTGTCACT	0.597													19	29	---	---	---	---					
