Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WNK3	65267	broad.mit.edu	37	X	54328282	54328282	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:54328282G>C	ENST00000354646.2	-	6	1538	c.1100C>G	c.(1099-1101)cCa>cGa	p.P367R	WNK3_ENST00000375159.2_Missense_Mutation_p.P367R|WNK3_ENST00000375169.3_Missense_Mutation_p.P367R	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	367	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						GAAGCTGGCTGGTTTTATGCC	0.333000													13	27					0	0	1	0	0
KLC1	3831	broad.mit.edu	37	14	104136555	104136555	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:104136555G>T	ENST00000389744.4	+	7	1191	c.922G>T	c.(922-924)Ggt>Tgt	p.G308C	KLC1_ENST00000334553.6_Missense_Mutation_p.G308C|KLC1_ENST00000246489.7_Missense_Mutation_p.G308C|KLC1_ENST00000452929.2_Missense_Mutation_p.G308C|KLC1_ENST00000554280.1_Missense_Mutation_p.G308C|KLC1_ENST00000557575.1_Missense_Mutation_p.G308C|KLC1_ENST00000553286.1_Missense_Mutation_p.G308C|KLC1_ENST00000445352.4_Missense_Mutation_p.G306C|KLC1_ENST00000557450.1_Missense_Mutation_p.G308C|KLC1_ENST00000348520.6_Missense_Mutation_p.G308C|KLC1_ENST00000347839.6_Missense_Mutation_p.G308C|KLC1_ENST00000380038.3_Missense_Mutation_p.G308C|RP11-73M18.2_ENST00000472726.2_Missense_Mutation_p.G480C|KLC1_ENST00000555836.1_Missense_Mutation_p.G308C			Q07866	KLC1_HUMAN	kinesin light chain 1	308					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				AGTCCTTTATGGTAAAAGAGG	0.408000													39	100					1.15183e-24	1.69406e-24	1	1	0
PKHD1	5314	broad.mit.edu	37	6	51907870	51907870	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:51907870A>G	ENST00000371117.3	-	27	3159	c.2884T>C	c.(2884-2886)Ttg>Ctg	p.L962L	PKHD1_ENST00000340994.4_Silent_p.L962L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	962	IPT/TIG 4.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GTAACCTGCAAGAACTGGGAG	0.368000													22	31					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15281357	15281357	+	Silent	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:15281357C>G	ENST00000263388.2	-	27	4974	c.4899G>C	c.(4897-4899)ccG>ccC	p.P1633P		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1633					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GAGGCTCCAGCGGCTCCCCTA	0.716000													24	19					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214576257	214576257	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:214576257G>A	ENST00000366956.5	-	6	744	c.550C>T	c.(550-552)Cag>Tag	p.Q184*	PTPN14_ENST00000543945.1_Nonsense_Mutation_p.Q184*	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	184	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GCTACCTTCTGGGTCAGCTCC	0.527000													55	103					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98628962	98628962	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr13:98628962C>A	ENST00000261574.5	+	4	246	c.66C>A	c.(64-66)gcC>gcA	p.A22A	IPO5_ENST00000490680.1_Silent_p.A4A|IPO5_ENST00000539640.1_Silent_p.A4A	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	4					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						TGGCGGCGGCCGCGGCGGAGC	0.706000													6	7					0.00116845	0.00121925	1	1	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													7	91					0	0	1	0	0
TCF15	6939	broad.mit.edu	37	20	590476	590476	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:590476C>A	ENST00000246080.3	-	1	566	c.406G>T	c.(406-408)Gac>Tac	p.D136Y		NM_004609.3	NP_004600.2	Q12870	TCF15_HUMAN	transcription factor 15 (basic helix-loop-helix)	136					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|lung(2)|prostate(1)	4		Breast(17;0.231)				GGCTGCCCGTCGTCGGCCGAG	0.736000													4	11					1	1	1	1	0
XIST	7503	broad.mit.edu	37	X	73063403	73063403	+	RNA	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:73063403T>A	ENST00000429829.1	-	0	9185					NR_001564.2																						GGAGATCAACTCTTAGTCTAA	0.373000													11	35					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146064571	146064571	+	Silent	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:146064571T>A	ENST00000454497.2	-	17	1571	c.1434A>T	c.(1432-1434)acA>acT	p.T478T	OTUD4_ENST00000455611.2_5'UTR|OTUD4_ENST00000447906.2_Silent_p.T543T	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	542							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					GTGATGAAACTGTTGCATATT	0.358000													13	19					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44151776	44151776	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:44151776G>T	ENST00000223357.3	+	17	2378	c.2073G>T	c.(2071-2073)tgG>tgT	p.W691C	AEBP1_ENST00000450684.2_Missense_Mutation_p.W266C	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	691	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						TGGGACTGTGGACTGAGGAGG	0.612000													32	31					9.65021e-13	1.1989e-12	1	1	0
CLCA3P	9629	broad.mit.edu	37	1	87104549	87104549	+	RNA	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:87104549C>A	ENST00000456587.1	-	0	294				CLCA3P_ENST00000466454.1_RNA																							AGATGTTCCACTCGTATTACT	0.378000													23	17					4.87955e-14	6.25341e-14	1	1	0
TDRKH	11022	broad.mit.edu	37	1	151751214	151751214	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:151751214T>C	ENST00000368822.1	-	6	1463	c.830A>G	c.(829-831)gAc>gGc	p.D277G	TDRKH_ENST00000368825.3_Missense_Mutation_p.D232G|TDRKH_ENST00000368827.6_Missense_Mutation_p.D277G|TDRKH_ENST00000368823.1_Missense_Mutation_p.D273G|TDRKH_ENST00000440583.2_Missense_Mutation_p.D53G|TDRKH_ENST00000368824.3_Missense_Mutation_p.D277G|TDRKH_ENST00000484421.1_5'UTR|TDRKH_ENST00000458431.2_Missense_Mutation_p.D277G			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	277							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTGAAAGCTGTCATCACTAGG	0.498000													24	54					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82815734	82815734	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:82815734A>T	ENST00000265077.3	+	7	2174	c.1609A>T	c.(1609-1611)Agc>Tgc	p.S537C	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.S489C|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.S537C	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	537	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAAAATGGTAAGCACTGTTTC	0.408000													21	86					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44394340	44394340	+	Missense_Mutation	SNP	C	C	G	rs61753598		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:44394340C>G	ENST00000371477.3	+	13	2071	c.1772C>G	c.(1771-1773)cCt>cGt	p.P591R		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	591	Interaction with DAPK3 (By similarity).|Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTACATCACCCTTATGAACCA	0.343000													33	66					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54566675	54566675	+	Splice_Site	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:54566675G>T	ENST00000336470.4	+	4	328	c.189_splice	c.e4+1	p.W63_splice	GNL3L_ENST00000489691.1_3'UTR|GNL3L_ENST00000360845.2_Splice_Site_p.W63_splice	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	63					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						AGAAGAAGTGGGTAAGCTTTT	0.493000													3	17					0.115264	0.116589	1	1	0
GCNT4	51301	broad.mit.edu	37	5	74325454	74325454	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:74325454A>T	ENST00000322348.4	-	1	1270	c.409T>A	c.(409-411)Ttg>Atg	p.L137M		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	137					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TGGACAACCAAAGAATAGGCT	0.398000													41	99					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212568853	212568853	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:212568853G>A	ENST00000342788.4	-	11	1575	c.1265C>T	c.(1264-1266)aCc>aTc	p.T422I	ERBB4_ENST00000402597.1_Missense_Mutation_p.T422I|ERBB4_ENST00000436443.1_Missense_Mutation_p.T422I	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	422					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCACCAATGGTCACCAGGTT	0.388000										TSP Lung(8;0.080)			40	67					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53104001	53104001	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:53104001C>G	ENST00000408890.4	+	1	653	c.637C>G	c.(637-639)Cgg>Ggg	p.R213G		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	213										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCTGCAGCCCCGGCCCTCTGC	0.672000													26	380					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44450084	44450084	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:44450084G>C	ENST00000360029.3	-	1	740	c.457C>G	c.(457-459)Cag>Gag	p.Q153E	AC131951.1_ENST00000584757.1_RNA	NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	153						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						AGAGAGTTCTGCTTGGTGACC	0.672000										HNSCC(17;0.042)			14	32					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13900315	13900315	+	Splice_Site	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:13900315C>A	ENST00000265104.4	-	15	2363	c.2259_splice	c.e15+1	p.K753_splice		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	753	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGTAGTATACCTTCATGTTAC	0.413000									Kartagener syndrome				23	45					1.50039e-11	1.84234e-11	1	1	0
ZNF17	7565	broad.mit.edu	37	19	57931275	57931275	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:57931275A>T	ENST00000307658.7	+	4	684	c.421A>T	c.(421-423)Agt>Tgt	p.S141C	AC003002.6_ENST00000596400.1_Missense_Mutation_p.151_151insC|AC004076.7_ENST00000597410.1_Intron|ZNF17_ENST00000601808.1_Missense_Mutation_p.S139C			P17021	ZNF17_HUMAN	zinc finger protein 17	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		TGTGAATGACAGTGTTCACCT	0.493000													46	71					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	36004080	36004080	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:36004080C>A	ENST00000339686.3	-	1	474	c.298G>T	c.(298-300)Ggg>Tgg	p.G100W	DMKN_ENST00000429837.1_Missense_Mutation_p.G100W|DMKN_ENST00000440396.1_Missense_Mutation_p.G100W|DMKN_ENST00000419602.1_Missense_Mutation_p.G100W|DMKN_ENST00000451297.2_Missense_Mutation_p.G100W|DMKN_ENST00000418261.1_Missense_Mutation_p.G100W|DMKN_ENST00000447113.2_Missense_Mutation_p.G100W|DMKN_ENST00000424570.2_Missense_Mutation_p.G100W	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	100	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCTGCTTCCCCGACCCTGTTG	0.597000													23	73					1.64293e-13	2.07528e-13	1	1	0
ZIC1	7545	broad.mit.edu	37	3	147130366	147130366	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:147130366C>A	ENST00000282928.4	+	2	1773	c.1044C>A	c.(1042-1044)gaC>gaA	p.D348E		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	348					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						ACAGCAGCGACCGCAAGAAGC	0.537000													36	116					6.29468e-14	8.04744e-14	1	1	0
RBMXL1	494115	broad.mit.edu	37	1	89449354	89449354	+	Silent	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:89449354A>T	ENST00000399794.2	-	3	871	c.156T>A	c.(154-156)gcT>gcA	p.A52A	CCBL2_ENST00000260508.4_Intron|RBMXL1_ENST00000413769.1_5'UTR|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000370485.2_Intron|RBMXL1_ENST00000321792.5_Silent_p.A52A|CCBL2_ENST00000370491.3_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	52	RRM.						nucleotide binding|RNA binding										AGGTGACAAAAGCAAATCCTC	0.418000											OREG0013593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	149					0	0	1	0	0
PPM1G	5496	broad.mit.edu	37	2	27606441	27606441	+	Silent	SNP	C	C	T	rs149149429		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:27606441C>T	ENST00000344034.4	-	7	1257	c.993G>A	c.(991-993)gcG>gcA	p.A331A	PPM1G_ENST00000350803.4_Silent_p.A331A	NM_177983.2	NP_817092.1	O15355	PPM1G_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1G	331					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					GGGCCACCACCGCTGTTGTAC	0.522000													10	16					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66361144	66361144	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:66361144A>G	ENST00000273854.3	-	4	1628	c.1028T>C	c.(1027-1029)tTc>tCc	p.F343S	EPHA5_ENST00000511294.1_Missense_Mutation_p.F343S|EPHA5_ENST00000354839.4_Missense_Mutation_p.F343S|EPHA5_ENST00000432638.2_Intron	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	343	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CTCTCTCCTGAAATAATCCTT	0.458000										TSP Lung(17;0.13)			52	44					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254756	51254756	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:51254756G>T	ENST00000404971.1	-	2	1995	c.656C>A	c.(655-657)gCg>gAg	p.A219E	NRXN1_ENST00000401669.2_Missense_Mutation_p.A219E|NRXN1_ENST00000406316.2_Missense_Mutation_p.A219E|NRXN1_ENST00000405472.3_Missense_Mutation_p.A219E|NRXN1_ENST00000402717.3_Missense_Mutation_p.A219E|NRXN1_ENST00000406859.3_Missense_Mutation_p.A219E|NRXN1_ENST00000405581.1_Missense_Mutation_p.A219E	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	219	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTCCTCGCCCGCCTCGCACGG	0.716000													4	9					0.00909568	0.00937992	1	1	0
DCAF15	90379	broad.mit.edu	37	19	14065187	14065187	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:14065187G>C	ENST00000254337.6	+	2	189	c.168G>C	c.(166-168)aaG>aaC	p.K56N		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	56										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						TCTTCCGGAAGCTGCCTCCCC	0.672000													13	57					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819588	50819588	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:50819588G>C	ENST00000374115.3	+	1	1242	c.802G>C	c.(802-804)Gcg>Ccg	p.A268P	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	268					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						ACCCTTCTCGGCGGCTGCACG	0.662000													14	42					0	0	1	0	0
TAS2R30	259293	broad.mit.edu	37	12	11285910	11285910	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:11285910T>C	ENST00000539585.1	-	1	1333	c.934A>G	c.(934-936)Aca>Gca	p.T312A	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_001097643.1	NP_001091112.1			taste receptor, type 2, member 30											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	13						GCCCCTCTTGTGAATCTATGG	0.378000													49	80					0	0	1	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186793575	186793575	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:186793575G>A	ENST00000169298.3	+	8	1879	c.1205G>A	c.(1204-1206)cGg>cAg	p.R402Q	ST6GAL1_ENST00000448044.1_Missense_Mutation_p.R402Q|ST6GAL1_ENST00000457772.2_Missense_Mutation_p.R171Q	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	402					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		CCTGGCTTCCGGACCATTCAC	0.512000													22	74					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377317	50377317	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:50377317C>A	ENST00000376020.2	-	4	1781	c.1756G>T	c.(1756-1758)Gag>Tag	p.E586*	SHROOM4_ENST00000460112.3_Nonsense_Mutation_p.E470*|SHROOM4_ENST00000289292.7_Nonsense_Mutation_p.E586*	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	586					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					GCAAAACGCTCACTCTTCCGC	0.582000													14	52					7.93312e-07	8.78132e-07	1	1	0
CNTN2	6900	broad.mit.edu	37	1	205031676	205031676	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:205031676A>T	ENST00000331830.4	+	10	1503	c.1219A>T	c.(1219-1221)Agc>Tgc	p.S407C		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	407	Ig-like C2-type 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CATCTACGCCAGCGCCGAGCT	0.587000													18	34					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7576593	7576593	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:7576593C>A	ENST00000379802.3	+	19	3038	c.2697C>A	c.(2695-2697)tgC>tgA	p.C899*	DSP_ENST00000418664.2_Nonsense_Mutation_p.C899*	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	899	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGCTTTCTGCAAGTGGCTCT	0.403000													29	61					1.68575e-08	1.93495e-08	1	1	0
ANGEL1	23357	broad.mit.edu	37	14	77256962	77256962	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:77256962T>C	ENST00000251089.2	-	9	1956	c.1844A>G	c.(1843-1845)aAc>aGc	p.N615S	ANGEL1_ENST00000557179.1_Missense_Mutation_p.N180S	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	615										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		ACCAGTTCTGTTCCCATTCTC	0.537000													31	68					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135602814	135602814	+	Nonsense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:135602814C>G	ENST00000356140.5	+	2	205	c.69C>G	c.(67-69)taC>taG	p.Y23*	ACMSD_ENST00000283054.4_5'UTR|ACMSD_ENST00000392928.1_5'UTR|AC016725.4_ENST00000392929.2_RNA	NM_138326.2	NP_612199.2	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	23					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			endometrium(3)|large_intestine(4)|lung(6)|skin(1)	14				BRCA - Breast invasive adenocarcinoma(221;0.115)		GGTTTGGCTACGGAGGCTGGG	0.527000													20	68					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171227265	171227265	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:171227265C>G	ENST00000354841.4	+	1	170	c.39C>G	c.(37-39)agC>agG	p.S13R	FMO1_ENST00000367750.3_Missense_Mutation_p.S13R|FMO1_ENST00000402921.2_Missense_Mutation_p.S13R|FMO1_ENST00000469112.1_3'UTR			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	13					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTGGGGTCAGCGGCCTGGCCT	0.572000													28	49					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79349974	79349974	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:79349974G>T	ENST00000233735.1	+	5	432	c.329G>T	c.(328-330)cGc>cTc	p.R110L		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	110	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding	p.R110P(1)|p.R110H(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						TAGAACCGCCGCTGGCACTGG	0.552000													32	93					1.60099e-16	2.09757e-16	1	1	0
TG	7038	broad.mit.edu	37	8	133935670	133935670	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:133935670G>T	ENST00000220616.4	+	22	4656	c.4616G>T	c.(4615-4617)gGg>gTg	p.G1539V	TG_ENST00000542445.1_5'UTR|TG_ENST00000377869.1_Intron	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1539	Thyroglobulin type-1 11.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGGGCAGTGGGAAGGCCTTC	0.587000													29	60					2.48779e-11	3.04064e-11	1	1	0
SLC32A1	140679	broad.mit.edu	37	20	37356657	37356657	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:37356657C>A	ENST00000217420.1	+	2	1216	c.953C>A	c.(952-954)aCg>aAg	p.T318K		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	318					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TTCAGCTACACGTCTCAGATC	0.567000													22	52					1.96292e-10	2.34485e-10	1	1	0
SIGLEC12	89858	broad.mit.edu	37	19	52000204	52000204	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:52000204G>T	ENST00000291707.3	-	7	1584	c.1529C>A	c.(1528-1530)gCa>gAa	p.A510E	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.A392E	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	510					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGCTGGCCTTGCCGATTTCTT	0.592000													33	54					1.67305e-13	2.10828e-13	1	1	0
FLG	2312	broad.mit.edu	37	1	152278979	152278979	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:152278979C>T	ENST00000368799.1	-	3	8418	c.8383G>A	c.(8383-8385)Gga>Aga	p.G2795R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2795	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCCTTCCTCCTCTGCTTGAC	0.592000									Ichthyosis				77	424					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85724475	85724475	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:85724475G>C	ENST00000322366.6	-	16	2982	c.2575C>G	c.(2575-2577)Ctg>Gtg	p.L859V	WDFY3_ENST00000295888.4_Missense_Mutation_p.L859V|WDFY3_ENST00000512267.1_5'UTR|WDFY3-AS1_ENST00000510449.1_RNA			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	859						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ACAGAGGCCAGTAGGTCCAGC	0.443000													14	32					0	0	1	0	0
PTH	5741	broad.mit.edu	37	11	13514017	13514017	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:13514017C>A	ENST00000282091.1	-	3	397	c.283G>T	c.(283-285)Gaa>Taa	p.E95*	PTH_ENST00000529816.1_Nonsense_Mutation_p.E95*	NM_000315.2	NP_000306.1	P01270	PTHY_HUMAN	parathyroid hormone	95					bone resorption|cAMP metabolic process|cell-cell signaling|cellular calcium ion homeostasis|cellular macromolecule biosynthetic process|induction of apoptosis by hormones|positive regulation of cAMP biosynthetic process|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|skeletal system development		hormone activity|peptide hormone receptor binding	p.E95K(1)		endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(625;0.00116)|Epithelial(150;0.0357)|LUSC - Lung squamous cell carcinoma(625;0.0836)		AGACTTTTTTCATGGCTCTCA	0.438000													40	28					4.40281e-34	6.7578e-34	1	1	0
CNOT2	4848	broad.mit.edu	37	12	70724182	70724182	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:70724182A>G	ENST00000229195.3	+	6	1081	c.502A>G	c.(502-504)Aga>Gga	p.R168G	CNOT2_ENST00000418359.3_Missense_Mutation_p.R168G|CNOT2_ENST00000548230.1_3'UTR	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	168					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			TAGCCCCAACAGAAGCTCGCC	0.448000													51	87					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31545284	31545284	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:31545284A>G	ENST00000389082.5	-	19	3647	c.3383T>C	c.(3382-3384)gTt>gCt	p.V1128A	DENND5B_ENST00000536562.1_Missense_Mutation_p.V1163A|DENND5B_ENST00000306833.6_Missense_Mutation_p.V1163A	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1128	RUN 2.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AAGGGCTGCAACCAGGCCATT	0.448000													12	27					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83402601	83402601	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:83402601G>T	ENST00000296591.5	-	6	935	c.517C>A	c.(517-519)Caa>Aaa	p.Q173K	EDIL3_ENST00000380138.3_Missense_Mutation_p.Q163K	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	173	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GCTGTGATTTGCTGGTTTGAT	0.393000													39	80					1.30998e-17	1.74664e-17	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155237080	155237080	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:155237080C>T	ENST00000357232.3	-	15	3714	c.3715G>A	c.(3715-3717)Gtt>Att	p.V1239I		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1239	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGTGCCAGAACAGTCAGAATA	0.383000													12	23					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154143352	154143352	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:154143352A>G	ENST00000404039.1	+	2	692	c.105A>G	c.(103-105)gcA>gcG	p.A35A	DPP6_ENST00000427557.1_Silent_p.A37A|DPP6_ENST00000406326.1_Silent_p.A99A|DPP6_ENST00000496611.1_3'UTR|DPP6_ENST00000377770.3_Silent_p.A99A|DPP6_ENST00000332007.3_Silent_p.A37A	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	99					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TAGCAATTGCACTGCTTGTCA	0.458000													24	49					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60193939	60193939	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:60193939G>T	ENST00000267484.5	-	3	1798	c.1463C>A	c.(1462-1464)cCc>cAc	p.P488H		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	488					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		CTTCATCGGGGGTGAGTCCTG	0.726000													5	6					3.59834e-05	3.8538e-05	1	1	0
E2F4	1874	broad.mit.edu	37	16	67226983	67226983	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:67226983A>T	ENST00000379378.3	+	3	376	c.317A>T	c.(316-318)gAg>gTg	p.E106V	E2F4_ENST00000564718.1_3'UTR	NM_001950.3	NP_001941.2	Q16254	E2F4_HUMAN	E2F transcription factor 4, p107/p130-binding	106	Dimerization (Potential).				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(4)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)	11		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		GAGATCGAGGAGCTGCAGCAG	0.592000													6	1					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16267027	16267027	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:16267027G>T	ENST00000343518.6	-	9	1473	c.1422C>A	c.(1420-1422)gcC>gcA	p.A474A		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	474								p.A474A(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TGTCAGCAGTGGCACCGTTAG	0.408000													47	504					9.22156e-22	1.31594e-21	1	1	0
DEFB118	117285	broad.mit.edu	37	20	29960671	29960671	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:29960671G>T	ENST00000253381.2	+	2	103	c.70G>T	c.(70-72)Gaa>Taa	p.E24*		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	24					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CTATAGTGGTGAAAAAAAATG	0.398000													14	38					9.31168e-06	1.00956e-05	1	1	0
CPQ	10404	broad.mit.edu	37	8	97892202	97892202	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:97892202C>T	ENST00000220763.5	+	4	1028	c.818C>T	c.(817-819)gCa>gTa	p.A273V		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	273					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										AACACTGTAGCAGAGATCACT	0.423000													45	103					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212274331	212274331	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:212274331G>T	ENST00000366991.4	+	14	2313	c.1999G>T	c.(1999-2001)Gca>Tca	p.A667S	DTL_ENST00000542077.1_Missense_Mutation_p.A625S|DTL_ENST00000475419.1_3'UTR	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	667					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		GTTGGCCATGGCAGCCAAACG	0.502000													18	39					1.01871e-10	1.21968e-10	1	1	0
C10orf113	387638	broad.mit.edu	37	10	21414891	21414891	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:21414891T>A	ENST00000534331.1	-	2	379	c.329A>T	c.(328-330)gAt>gTt	p.D110V	C10orf113_ENST00000529198.1_3'UTR|C10orf113_ENST00000377118.4_Missense_Mutation_p.D100V|NEBL_ENST00000417816.2_Intron	NM_001010896.2	NP_001010896.2	Q5VZT2	CJ113_HUMAN	chromosome 10 open reading frame 113	110			D -> H (in dbSNP:rs625223).							endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|pancreas(1)	7						GTTGCCTGGATCTGGTTCAGG	0.542000													56	48					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61613155	61613155	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:61613155G>A	ENST00000583023.1	+	6	1238	c.1227G>A	c.(1225-1227)gcG>gcA	p.A409A	KCNH6_ENST00000580652.1_Silent_p.A409A|KCNH6_ENST00000581784.1_Silent_p.A409A|KCNH6_ENST00000456941.2_Silent_p.A409A|KCNH6_ENST00000314672.5_Silent_p.A409A	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	409					regulation of transcription, DNA-dependent|signal transduction			p.A409A(1)		breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GCACCTTCGCGCTCATAGCGC	0.632000													27	118					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139874648	139874648	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:139874648C>A	ENST00000224167.2	+	5	639	c.564C>A	c.(562-564)acC>acA	p.T188T	PTGDS_ENST00000371625.3_Silent_p.T154T			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	154					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GAACCCAGACCCCCAGGGCTG	0.642000													15	9					2.61681e-11	3.19094e-11	1	1	0
SLC8B1	80024	broad.mit.edu	37	12	113759145	113759145	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:113759145C>T	ENST00000552014.1	-	4	680	c.165G>A	c.(163-165)aaG>aaA	p.K55K	SLC24A6_ENST00000553238.1_5'UTR|SLC24A6_ENST00000202831.3_Silent_p.K55K|SLC24A6_ENST00000546737.1_Silent_p.K55K			Q6J4K2	NCKX6_HUMAN		55					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						GGCCACACACCTTGCGGCACT	0.557000													56	134					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224463094	224463094	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:224463094C>A	ENST00000281701.6	-	17	2288	c.2029G>T	c.(2029-2031)Gtg>Ttg	p.V677L	NVL_ENST00000469075.1_Missense_Mutation_p.V586L|NVL_ENST00000340871.4_Missense_Mutation_p.V488L|NVL_ENST00000391875.2_Missense_Mutation_p.V571L|NVL_ENST00000361463.3_Missense_Mutation_p.V571L|NVL_ENST00000482491.1_Missense_Mutation_p.V401L	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	677						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		AAGAATATCACACAGGGTGCT	0.398000													37	66					4.62619e-21	6.53109e-21	1	1	0
CCDC70	83446	broad.mit.edu	37	13	52439979	52439979	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr13:52439979C>A	ENST00000242819.4	+	2	761	c.465C>A	c.(463-465)gcC>gcA	p.A155A		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	155						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		AGGACAAGGCCCTGTGGGAGG	0.532000													53	36					5.22555e-25	7.75026e-25	1	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90499929	90499929	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:90499929C>A	ENST00000325643.5	+	4	593	c.527C>A	c.(526-528)cCg>cAg	p.P176Q		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCCCACCAGCCGCATGGGAAA	0.642000													31	23					2.85442e-18	3.88436e-18	1	1	0
MAGEC1	9947	broad.mit.edu	37	X	140993225	140993225	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:140993225C>A	ENST00000285879.4	+	4	321	c.35C>A	c.(34-36)cCg>cAg	p.P12Q	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	12							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGGGATGCCGAGTCTTCTC	0.547000										HNSCC(15;0.026)			33	62					1.99505e-19	2.75036e-19	1	1	0
PPP2R3B	28227	broad.mit.edu	37	X	299616	299616	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:299616T>C	ENST00000390665.3	-	11	1385	c.1367A>G	c.(1366-1368)cAg>cGg	p.Q456R		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	456					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTTCAGGTCCTGCAGCGTGAT	0.622000													29	58					0	0	1	0	0
SYNGR4	23546	broad.mit.edu	37	19	48879451	48879451	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:48879451C>A	ENST00000344846.2	+	5	831	c.581C>A	c.(580-582)tCt>tAt	p.S194Y	SYNGR4_ENST00000601610.1_3'UTR|SYNGR4_ENST00000595322.1_3'UTR	NM_012451.3	NP_036583.2	O95473	SNG4_HUMAN	synaptogyrin 4	194						integral to membrane				breast(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		CCCTTGCCCTCTGCCAACAGC	0.617000													34	62					1.56442e-22	2.25072e-22	1	1	0
FER1L6	654463	broad.mit.edu	37	8	125115551	125115551	+	Splice_Site	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:125115551G>C	ENST00000522917.1	+	39	5495		c.e39+1		FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Splice_Site	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)							integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGAACTCACAGTAAGTGACAG	0.443000													27	74					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890617	32890617	+	RNA	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:32890617G>T	ENST00000330048.5	-	0	3181					NR_003083.2																						GTACACGTTGGTGTTTTTGTA	0.617000													8	24					0.000274275	0.000287907	1	1	0
ANKRD11	29123	broad.mit.edu	37	16	89347118	89347118	+	Silent	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:89347118G>C	ENST00000301030.4	-	9	6292	c.5832C>G	c.(5830-5832)acC>acG	p.T1944T	ANKRD11_ENST00000378330.2_Silent_p.T1944T	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1944	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CGGGCTCCTCGGTGATGACGG	0.692000													55	24					0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51075942	51075942	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:51075942C>A	ENST00000376006.3	+	2	345	c.125C>A	c.(124-126)cCg>cAg	p.P42Q	NUDT10_ENST00000356450.2_Missense_Mutation_p.P42Q	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	42	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					AGCCGGTACCCGGACCGCTGG	0.701000													6	16					0.248553	0.25045	1	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912561	77912561	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:77912561G>T	ENST00000321110.1	-	2	1652	c.1357C>A	c.(1357-1359)Cat>Aat	p.H453N		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	453							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						CTGGCAAAATGACCAGGATAA	0.557000													16	43					5.03518e-11	6.05598e-11	1	1	0
PDE11A	50940	broad.mit.edu	37	2	178681604	178681604	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:178681604C>T	ENST00000286063.5	-	9	2006	c.1689G>A	c.(1687-1689)atG>atA	p.M563I	PDE11A_ENST00000449286.2_Missense_Mutation_p.M205I|PDE11A_ENST00000409504.1_Missense_Mutation_p.M205I|PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000358450.4_Missense_Mutation_p.M313I|PDE11A_ENST00000389683.3_Missense_Mutation_p.M119I	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	563					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CTTGATCATACATAATTGTGT	0.393000									Primary Pigmented Nodular Adrenocortical Disease, Familial				29	67					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42695191	42695191	+	Splice_Site	SNP	G	G	T	rs45501892		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:42695191G>T	ENST00000230882.4	+	5	629	c.439_splice	c.e5+1	p.V147_splice	GHR_ENST00000537449.1_5'UTR|GHR_ENST00000357703.3_Splice_Site_p.V125_splice	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	147					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGATGAAATAGGTAAATCACA	0.353000													15	40					3.45872e-05	3.71935e-05	1	1	0
KLHL34	257240	broad.mit.edu	37	X	21674328	21674328	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:21674328C>A	ENST00000379499.2	-	1	2120	c.1579G>T	c.(1579-1581)Gct>Tct	p.A527S		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	527										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						GCAAACACAGCGCCGCGCAGC	0.647000													10	6					1.58986e-06	1.74885e-06	1	1	0
SPOP	8405	broad.mit.edu	37	17	47684716	47684716	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:47684716C>T	ENST00000393331.3	-	10	1203	c.733G>A	c.(733-735)Gat>Aat	p.D245N	SPOP_ENST00000503676.1_Missense_Mutation_p.D245N|SPOP_ENST00000393328.2_Missense_Mutation_p.D245N|SPOP_ENST00000347630.2_Missense_Mutation_p.D245N|SPOP_ENST00000504102.1_Missense_Mutation_p.D245N	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	245	BTB.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						GGCTCCACATCATTGATTTCA	0.383000										Prostate(2;0.17)			26	62					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134025991	134025991	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:134025991C>A	ENST00000220616.4	+	37	6584	c.6544C>A	c.(6544-6546)Cac>Aac	p.H2182N	TG_ENST00000519543.1_Missense_Mutation_p.H315N|TG_ENST00000522523.1_3'UTR|TG_ENST00000542445.1_Missense_Mutation_p.H552N|TG_ENST00000377869.1_Missense_Mutation_p.H2125N	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2182					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGAGGCCACCCACATCTACCG	0.522000													6	27					8.12818e-05	8.61783e-05	1	1	0
FREM2	341640	broad.mit.edu	37	13	39425150	39425150	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr13:39425150G>C	ENST00000280481.7	+	10	6863	c.6647G>C	c.(6646-6648)cGc>cCc	p.R2216P		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2216	Calx-beta 4.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GAGGAGCTCCGCCTGGTACTC	0.488000													29	42					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953170	140953170	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:140953170G>A	ENST00000277549.5	+	30	4615	c.2046G>A	c.(2044-2046)gtG>gtA	p.V682V	CACNA1B_ENST00000371357.1_Silent_p.V1487V|CACNA1B_ENST00000277551.2_Silent_p.V1486V|CACNA1B_ENST00000371363.1_Silent_p.V1486V|CACNA1B_ENST00000371372.1_Silent_p.V1486V|CACNA1B_ENST00000371355.4_Silent_p.V1487V			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1486					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCAACACTGTGGTGCTGATGA	0.557000													7	11					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54614664	54614664	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:54614664C>A	ENST00000302287.3	+	3	677	c.271C>A	c.(271-273)Ccg>Acg	p.P91T	VSTM2A_ENST00000498834.1_3'UTR|VSTM2A_ENST00000404951.1_Missense_Mutation_p.P91T|VSTM2A_ENST00000402026.2_Missense_Mutation_p.P90T|VSTM2A_ENST00000407838.3_Missense_Mutation_p.P91T|VSTM2A_ENST00000402613.3_Missense_Mutation_p.P91T			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	91	Ig-like V-type.					extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			CGACAGAGACCCGGACAGCGA	0.726000													22	532					2.48779e-11	3.04064e-11	1	1	0
ARHGAP31	57514	broad.mit.edu	37	3	119101206	119101206	+	Missense_Mutation	SNP	G	G	T	rs139733647	by1000genomes	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:119101206G>T	ENST00000264245.4	+	5	1031	c.499G>T	c.(499-501)Gcc>Tcc	p.A167S		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	167	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						CAACATGCACGCCCGGAACCT	0.557000													20	98					2.39187e-15	3.11829e-15	1	1	0
CNOT1	23019	broad.mit.edu	37	16	58566252	58566252	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:58566252A>G	ENST00000317147.5	-	41	6275	c.5943T>C	c.(5941-5943)cgT>cgC	p.R1981R	CNOT1_ENST00000569240.1_Silent_p.R1976R|CNOT1_ENST00000245138.4_Silent_p.R832R	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1981					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATTCACTCTGACGAACATCAT	0.403000													50	26					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152278978	152278978	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:152278978C>A	ENST00000368799.1	-	3	8419	c.8384G>T	c.(8383-8385)gGa>gTa	p.G2795V	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2795	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCCTTCCTCCTCTGCTTGA	0.597000									Ichthyosis				76	423					2.10578e-59	3.34895e-59	1	1	0
GAL3ST3	89792	broad.mit.edu	37	11	65810520	65810520	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:65810520G>T	ENST00000312006.4	-	3	1035	c.754C>A	c.(754-756)Cgg>Agg	p.R252R	GAL3ST3_ENST00000527878.1_Silent_p.R252R	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	252					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity	p.R252W(1)		kidney(1)|lung(9)|ovary(2)|skin(2)	14						AGTAGGCGCCGCAGCAGCACT	0.706000													34	21					1.21669e-08	1.40265e-08	1	1	0
DMD	1756	broad.mit.edu	37	X	31200941	31200941	+	Silent	SNP	G	G	A	rs146543659		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:31200941G>A	ENST00000357033.4	-	68	10094	c.9888C>T	c.(9886-9888)ccC>ccT	p.P3296P	DMD_ENST00000359836.1_Silent_p.P836P|DMD_ENST00000378707.3_Silent_p.P836P|DMD_ENST00000378702.4_Silent_p.P228P|DMD_ENST00000343523.2_Silent_p.P836P|DMD_ENST00000378723.3_Silent_p.P228P|DMD_ENST00000378680.2_Silent_p.P228P|DMD_ENST00000361471.4_Silent_p.P228P|DMD_ENST00000541735.1_Silent_p.P836P|DMD_ENST00000378677.2_Silent_p.P3292P|DMD_ENST00000474231.1_Silent_p.P836P	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3296	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGTGCAGGACGGGCAGCCACA	0.512000													17	59					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50912138	50912138	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:50912138C>T	ENST00000440232.2	+	15	1925	c.1872C>T	c.(1870-1872)ccC>ccT	p.P624P	POLD1_ENST00000599857.1_Silent_p.P624P|POLD1_ENST00000595904.1_Silent_p.P650P	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	624					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TCCTTCGGCCCGGGACTGCAC	0.617000								DNA polymerases (catalytic subunits)					52	81					0	0	1	0	0
NSA2	10412	broad.mit.edu	37	5	74064769	74064769	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:74064769A>C	ENST00000296802.5	+	2	386	c.17A>C	c.(16-18)tAt>tCt	p.Y6S	NSA2_ENST00000513356.1_3'UTR	NM_014886.3	NP_055701.1	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog (S. cerevisiae)	6					rRNA processing	nucleolus|ribonucleoprotein complex				breast(1)|endometrium(2)|kidney(1)|lung(1)|ovary(1)|skin(1)	7						CAGAATGAATATATTGAATTA	0.333000													6	11					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54321016	54321016	+	Nonsense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:54321016T>A	ENST00000354646.2	-	8	2101	c.1663A>T	c.(1663-1665)Aaa>Taa	p.K555*	WNK3_ENST00000375159.2_Nonsense_Mutation_p.K555*|WNK3_ENST00000375169.3_Nonsense_Mutation_p.K555*	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	555					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						TGCTGTGGTTTTCTTTGTAGA	0.398000													8	46					0	0	1	0	0
RASA1	5921	broad.mit.edu	37	5	86686641	86686641	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:86686641A>G	ENST00000456692.2	+	25	2669	c.2554A>G	c.(2554-2556)Ata>Gta	p.I852V	RASA1_ENST00000506290.1_Missense_Mutation_p.I863V|RASA1_ENST00000512763.1_Missense_Mutation_p.I862V|RASA1_ENST00000274376.6_Missense_Mutation_p.I1029V	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	1029	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GCTTCTGGCTATAACAGAACT	0.408000													21	39					0	0	1	0	0
TMEM63C	57156	broad.mit.edu	37	14	77703003	77703003	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:77703003C>A	ENST00000298351.4	+	9	723	c.579C>A	c.(577-579)ttC>ttA	p.F193L		NM_020431.2	NP_065164.2	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	193						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(1)	23			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		TGCTGTCCTTCTTCTACTTCA	0.557000													36	86					1.30998e-17	1.74664e-17	1	1	0
NPAP1	23742	broad.mit.edu	37	15	24922856	24922856	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:24922856G>A	ENST00000329468.2	+	1	2316	c.1842G>A	c.(1840-1842)ccG>ccA	p.P614P		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		AGAGGCACCCGGGAAAGACAT	0.478000													26	53					0	0	1	0	0
EXO1	9156	broad.mit.edu	37	1	242020758	242020758	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:242020758G>T	ENST00000366548.3	+	7	1110	c.517G>T	c.(517-519)Gat>Tat	p.D173Y	EXO1_ENST00000493702.1_3'UTR|EXO1_ENST00000518483.1_Missense_Mutation_p.D173Y|EXO1_ENST00000348581.5_Missense_Mutation_p.D173Y	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	173	I-domain.|Interaction with MSH3.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			AGAGGACTCGGATCTCCTAGC	0.428000								Editing and processing nucleases					33	72					7.63091e-17	1.00728e-16	1	1	0
CRB1	23418	broad.mit.edu	37	1	197390165	197390165	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:197390165T>C	ENST00000367400.3	+	6	1342	c.1207T>C	c.(1207-1209)Tca>Cca	p.S403P	CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000367399.2_Missense_Mutation_p.S291P|CRB1_ENST00000535699.1_Missense_Mutation_p.S334P|CRB1_ENST00000476483.1_3'UTR|CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000538660.1_Missense_Mutation_p.S403P|CRB1_ENST00000543483.1_Missense_Mutation_p.S102P	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	403	EGF-like 10; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TGAATGTTCTTCAAACCCTTG	0.348000													39	94					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584698	30584698	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:30584698T>A	ENST00000217299.3	+	3	1352	c.1178T>A	c.(1177-1179)cTg>cAg	p.L393Q		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	393						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			ATCGTCCTGCTGGAGAACGCC	0.592000													15	32					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141423765	141423765	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:141423765T>C	ENST00000397541.2	+	7	1458	c.1052T>C	c.(1051-1053)aTg>aCg	p.M351T	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	351	Protein kinase.			M -> V (in Ref. 2; AK131218).	egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					TGTCACAAGATGCAAAGTGAA	0.328000													10	26					0	0	1	0	0
SP5	389058	broad.mit.edu	37	2	171573656	171573656	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:171573656G>T	ENST00000375281.3	+	2	1101	c.939G>T	c.(937-939)ctG>ctT	p.L313L		NM_001003845.2	NP_001003845.1	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|lung(1)|prostate(1)	5						CGTCGCACCTGAAGGCGCACC	0.706000													4	10					1	1	1	1	0
SEMA3D	223117	broad.mit.edu	37	7	84628850	84628850	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:84628850C>A	ENST00000284136.6	-	17	2283	c.2240G>T	c.(2239-2241)gGc>gTc	p.G747V	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	747	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						CCACTTTGGGCCCCCCTTGTT	0.498000													28	73					4.87955e-14	6.25341e-14	1	1	0
SH3RF2	153769	broad.mit.edu	37	5	145393619	145393619	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:145393619G>C	ENST00000511217.1	+	4	1106	c.1054G>C	c.(1054-1056)Gga>Cga	p.G352R	SH3RF2_ENST00000359120.4_Missense_Mutation_p.G352R			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	352							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCTGTGTGGGACAGGTAGG	0.507000													32	52					0	0	1	0	0
RGMB	285704	broad.mit.edu	37	5	98128960	98128960	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:98128960G>C	ENST00000308234.7	+	5	1342	c.940G>C	c.(940-942)Gcc>Ccc	p.A314P	RGMB_ENST00000513185.1_Missense_Mutation_p.A273P	NM_001012761.2	NP_001012779.2	Q6NW40	RGMB_HUMAN	repulsive guidance molecule family member b	273					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	10		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		GGAGATGCACGCCCGCTATAT	0.607000													17	34					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61761091	61761091	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:61761091G>A	ENST00000423902.2	+	24	5707	c.5228G>A	c.(5227-5229)cGc>cAc	p.R1743H	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1743					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTGCGTGTCCGCATGCTGTAC	0.502000													11	19					0	0	1	0	0
SLC25A53	401612	broad.mit.edu	37	X	103349901	103349901	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:103349901G>T	ENST00000357421.4	-	2	220	c.40C>A	c.(40-42)Cac>Aac	p.H14N		NM_001012755.3	NP_001012773.2	Q5H9E4	MCAR6_HUMAN	solute carrier family 25, member 53	14					transport	integral to membrane|mitochondrial inner membrane											CGCGTCCTGTGCTGAAGCTCC	0.527000													19	51					1.2644e-06	1.39666e-06	1	1	0
LMTK3	114783	broad.mit.edu	37	19	49004799	49004799	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:49004799C>A	ENST00000600059.1	-	8	1042	c.815G>T	c.(814-816)tGc>tTc	p.C272F	LMTK3_ENST00000270238.3_Missense_Mutation_p.C301F					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGTCAGCAGGCAGTTGCGCAG	0.672000													7	16					0.000274275	0.000287907	1	1	0
TRAV12-3	28672	broad.mit.edu	37	14	22433772	22433772	+	RNA	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:22433772T>A	ENST00000390442.3	+	0	93																											GGTGATCCTGTGGCTTCAGTT	0.368000													14	42					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153693822	153693822	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:153693822G>T	ENST00000369682.3	+	12	2475	c.2300G>T	c.(2299-2301)tGg>tTg	p.W767L		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	767					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCGTGGTCTGGGATGGAGAC	0.572000													53	82					4.32865e-36	6.74197e-36	1	1	0
VCAN	1462	broad.mit.edu	37	5	82816584	82816584	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:82816584C>A	ENST00000265077.3	+	7	3024	c.2459C>A	c.(2458-2460)cCt>cAt	p.P820H	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.P772H|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.P820H	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	820	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCTACAGAACCTTCAGCCTCT	0.433000													24	68					2.21704e-12	2.74144e-12	1	1	0
MAGEA11	4110	broad.mit.edu	37	X	148797311	148797311	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:148797311C>A	ENST00000355220.5	+	4	342	c.240C>A	c.(238-240)acC>acA	p.T80T	MAGEA11_ENST00000333104.4_Silent_p.T51T	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	80						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CCAGGAGAACCCAGAGGATCA	0.502000													74	109					3.47267e-51	5.50622e-51	1	1	0
ZNF479	90827	broad.mit.edu	37	7	57194308	57194308	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:57194308C>A	ENST00000331162.4	-	3	427	c.157G>T	c.(157-159)Gtc>Ttc	p.V53F		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	53	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			CCCAGGGAGACCAGGTTTCTG	0.368000													31	253					8.4185e-14	1.07366e-13	1	1	0
ZP4	57829	broad.mit.edu	37	1	238050124	238050124	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:238050124A>G	ENST00000366570.4	-	6	944	c.786T>C	c.(784-786)acT>acC	p.T262T	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	262	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCACATCCCTAGTTGCCACCA	0.473000													20	67					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111625197	111625197	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:111625197G>A	ENST00000333999.3	+	1	595	c.595G>A	c.(595-597)Gcc>Acc	p.A199T		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	199						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						AATGCACATCGCCTACCAGTC	0.577000													31	20					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55602953	55602953	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:55602953G>T	ENST00000288135.5	+	19	2760	c.2663G>T	c.(2662-2664)cGg>cTg	p.R888L		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	888	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GAAGGCTTCCGGATGCTCAGC	0.428000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				24	54					3.7963e-18	5.13961e-18	1	1	0
HECTD4	283450	broad.mit.edu	37	12	112600979	112600979	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:112600979C>T	ENST00000550722.1	-	75	12944	c.12549G>A	c.(12547-12549)gaG>gaA	p.E4183E	HECTD4_ENST00000430131.2_Silent_p.E3907E|HECTD4_ENST00000377560.5_Silent_p.E4157E	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		ACTTGCACAGCTCCTCCTGGG	0.617000													15	71					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15918146	15918146	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:15918146C>A	ENST00000217246.4	+	12	1259	c.864C>A	c.(862-864)ccC>ccA	p.P288P	MACROD2_ENST00000310348.4_Silent_p.P288P|MACROD2_ENST00000378058.3_Silent_p.P53P|MACROD2_ENST00000402914.1_Silent_p.P53P	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	288	Glu-rich.							p.P53P(1)|p.P288P(1)		breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				TCACTGTGCCCGGCCCTGCTT	0.463000													43	86					1.47857e-17	1.96647e-17	1	1	0
FBXO38	81545	broad.mit.edu	37	5	147820769	147820769	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:147820769C>T	ENST00000340253.5	+	21	3525	c.3357C>T	c.(3355-3357)ttC>ttT	p.F1119F	FBXO38_ENST00000394370.3_Silent_p.F1044F|FBXO38_ENST00000513826.1_Silent_p.F874F|FBXO38_ENST00000296701.6_Silent_p.F874F			Q6PIJ6	FBX38_HUMAN	F-box protein 38	1119						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAACAGCTTCGCTCGATACG	0.403000													38	56					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68140271	68140271	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:68140271G>A	ENST00000262215.3	-	25	3907	c.3518C>T	c.(3517-3519)tCa>tTa	p.S1173L	ARFGEF1_ENST00000518230.1_Missense_Mutation_p.S11L|ARFGEF1_ENST00000520381.1_Missense_Mutation_p.S627L	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1173					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GTTGTAATATGATATTTCTAC	0.343000													16	51					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3991474	3991474	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:3991474G>A	ENST00000404826.2	+	7	1211	c.1072G>A	c.(1072-1074)Ggg>Agg	p.G358R	SDK1_ENST00000389531.3_Missense_Mutation_p.G358R	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	358	Ig-like C2-type 3.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CGCGGACACCGGGCCATACGT	0.607000													28	26					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146480485	146480485	+	Splice_Site	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:146480485G>T	ENST00000392299.2	+	3	1172	c.700_splice	c.e3-1	p.G234_splice	GRM1_ENST00000355289.4_Splice_Site_p.G234_splice|GRM1_ENST00000507907.1_Splice_Site_p.G234_splice|GRM1_ENST00000492807.2_Splice_Site_p.G234_splice|GRM1_ENST00000361719.2_Splice_Site_p.G234_splice|GRM1_ENST00000282753.1_Splice_Site_p.G234_splice			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	234					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCTGGACAGGGAATTATGGGG	0.473000													22	63					1.17739e-12	1.4593e-12	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152529292	152529292	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:152529292C>T	ENST00000367255.5	-	125	23240	c.22639G>A	c.(22639-22641)Gtg>Atg	p.V7547M	SYNE1_ENST00000341594.5_Missense_Mutation_p.V7159M|SYNE1_ENST00000356820.4_Missense_Mutation_p.V2071M|SYNE1_ENST00000265368.4_Missense_Mutation_p.V7547M|SYNE1_ENST00000448038.1_Missense_Mutation_p.V7476M|SYNE1_ENST00000423061.1_Missense_Mutation_p.V7476M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7547					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCGAATCACTCCCTGCCAT	0.473000										HNSCC(10;0.0054)			20	43					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151138711	151138711	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:151138711T>A	ENST00000370325.1	-	2	273	c.220A>T	c.(220-222)Atc>Ttc	p.I74F	GABRE_ENST00000370328.3_Missense_Mutation_p.I74F|GABRE_ENST00000393914.3_5'UTR			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	74					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GTGTTCAGGATGCGAGAGGCT	0.542000													78	109					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37026510	37026510	+	Silent	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:37026510G>C	ENST00000358047.3	+	1	79	c.27G>C	c.(25-27)cgG>cgC	p.R9R		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	9								p.R9R(2)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CGCAGGACCGGCCCAGTTCCC	0.657000													6	27					0	0	1	0	0
CATSPER2	117155	broad.mit.edu	37	15	43940221	43940221	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:43940221G>T	ENST00000396879.1	-	3	151	c.39C>A	c.(37-39)ccC>ccA	p.P13P	STRC_ENST00000541030.1_Intron|CATSPER2_ENST00000321596.5_Silent_p.P13P|CATSPER2_ENST00000381761.1_Silent_p.P19P|CATSPER2_ENST00000355438.2_Silent_p.P13P|CATSPER2_ENST00000464721.1_Intron|CATSPER2_ENST00000354127.4_Silent_p.P13P			Q96P56	CTSR2_HUMAN	cation channel, sperm associated 2	13					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CATCAGCTCGGGGAAGCTGCA	0.488000													186	105					5.80983e-94	9.26765e-94	1	1	0
OTUD7B	56957	broad.mit.edu	37	1	149939440	149939440	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:149939440C>T	ENST00000369135.3	-	4	575	c.281G>A	c.(280-282)cGc>cAc	p.R94H	OTUD7B_ENST00000479905.1_Intron	NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	94					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CCTAGACAGGCGTTTTTCTGC	0.542000													9	31					0	0	1	0	0
XIAP	331	broad.mit.edu	37	X	123019940	123019940	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:123019940C>A	ENST00000371199.3	+	2	727	c.428C>A	c.(427-429)aCt>aAt	p.T143N	XIAP_ENST00000468691.1_Intron|XIAP_ENST00000434753.3_Missense_Mutation_p.T143N|XIAP_ENST00000355640.3_Missense_Mutation_p.T143N	NM_001167.3	NP_001158.2	P98170	XIAP_HUMAN	X-linked inhibitor of apoptosis	143	Interaction with caspase-7.				anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)	25						CTTTTGAGAACTGGGCAGGTT	0.428000									X-linked Lymphoproliferative syndrome				43	99					1.5731e-28	2.37994e-28	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113347703	113347703	+	Splice_Site	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:113347703C>G	ENST00000297405.5	-	45	7264	c.7019_splice	c.e45-1	p.W2340_splice	CSMD3_ENST00000352409.3_Splice_Site_p.W2270_splice|CSMD3_ENST00000455883.2_Splice_Site_p.W2236_splice|CSMD3_ENST00000343508.3_Splice_Site_p.W2300_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2340	CUB 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTGGTCCATCCCTATGAGACA	0.368000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	31					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304968	10304968	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:10304968G>T	ENST00000403437.2	-	23	2917	c.2823C>A	c.(2821-2823)gcC>gcA	p.A941A	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	941					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TTCTCTTCTTGGCTGTCAGCT	0.448000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				60	78					8.72158e-25	1.28631e-24	1	1	0
NXPE3	91775	broad.mit.edu	37	3	101540442	101540442	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:101540442A>G	ENST00000422132.1	+	5	1521	c.1324A>G	c.(1324-1326)Ata>Gta	p.I442V	NXPE3_ENST00000491511.1_Missense_Mutation_p.I442V|NXPE3_ENST00000273347.5_Missense_Mutation_p.I442V|NXPE3_ENST00000477909.1_Missense_Mutation_p.I442V					neurexophilin and PC-esterase domain family, member 3																		AGTGGTTGCCATAGCTGTATG	0.542000													14	49					0	0	1	0	0
PAQR5	54852	broad.mit.edu	37	15	69682054	69682054	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:69682054T>G	ENST00000340965.3	+	6	1115	c.447T>G	c.(445-447)caT>caG	p.H149Q	PAQR5_ENST00000561027.1_3'UTR|PAQR5_ENST00000395407.2_Missense_Mutation_p.H149Q|PAQR5_ENST00000561153.1_Missense_Mutation_p.H149Q	NM_001104554.1	NP_001098024.1	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	149					cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|skin(1)	11						CCACTTTCCATGACTACTACG	0.592000													30	58					0	0	1	0	0
FXYD1	5348	broad.mit.edu	37	19	35631532	35631532	+	Splice_Site	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:35631532C>T	ENST00000588081.1	+	2	151	c.94_splice	c.e2+1	p.Y31_splice	FXYD1_ENST00000589209.1_Splice_Site_p.Y31_splice|FXYD1_ENST00000588715.1_Splice_Site_p.Y31_splice|FXYD1_ENST00000351325.4_Splice_Site_p.Y31_splice|FXYD1_ENST00000455515.2_Splice_Site_p.Y31_splice|CTD-2527I21.4_ENST00000592174.1_RNA|LGI4_ENST00000493050.1_Intron|FXYD1_ENST00000588607.1_Splice_Site_p.Y31_splice			O00168	PLM_HUMAN	FXYD domain containing ion transport regulator 1	31					muscle contraction	chloride channel complex|integral to plasma membrane	chloride channel activity			lung(3)	3	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;2.32e-21)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;2.43e-18)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CGTTCACTTACGGTGAGCGGG	0.562000													20	52					0	0	1	0	0
RAD9B	144715	broad.mit.edu	37	12	110957688	110957688	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:110957688C>G	ENST00000409246.1	+	9	966	c.641C>G	c.(640-642)cCa>cGa	p.P214R	RAD9B_ENST00000392672.4_Missense_Mutation_p.P286R|RAD9B_ENST00000409425.1_Missense_Mutation_p.P214R|RAD9B_ENST00000409300.1_Missense_Mutation_p.P286R|RAD9B_ENST00000409778.3_Missense_Mutation_p.P217R			Q6WBX8	RAD9B_HUMAN	RAD9 homolog B (S. pombe)	283					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			endometrium(1)|large_intestine(2)|lung(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	7						GCATCTTCACCACAGTCACTG	0.353000													18	20					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723368	142723368	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:142723368G>A	ENST00000350513.2	-	1	914	c.852C>T	c.(850-852)ttC>ttT	p.F284F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					GAGTAAAGATGAAAGGATTCA	0.438000													32	69					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86772938	86772938	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:86772938C>A	ENST00000373119.4	+	1	187	c.42C>A	c.(40-42)atC>atA	p.I14I	KLHL4_ENST00000373114.4_Silent_p.I14I	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	14						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TGAAACAGATCCTAAGGCTAC	0.478000													54	123					3.28156e-27	4.90839e-27	1	1	0
CLEC1A	51267	broad.mit.edu	37	12	10223974	10223974	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:10223974C>G	ENST00000315330.4	-	6	863	c.801G>C	c.(799-801)gaG>gaC	p.E267D	CLEC1A_ENST00000457018.2_Missense_Mutation_p.E234D|CLEC1A_ENST00000420265.2_Missense_Mutation_p.E175D	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	267					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						CATGGAGGCTCTCTGGCTTCA	0.517000													58	133					0	0	1	0	0
FAM98C	147965	broad.mit.edu	37	19	38894075	38894075	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:38894075G>T	ENST00000252530.5	+	2	182	c.163G>T	c.(163-165)Gcc>Tcc	p.A55S	FAM98C_ENST00000588262.1_Missense_Mutation_p.A55S|FAM98C_ENST00000343358.7_Missense_Mutation_p.A55S	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	55										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GACGCTGGGCGCCCTCGAGCA	0.766000													5	11					0.0215528	0.0219265	1	1	0
ITGAL	3683	broad.mit.edu	37	16	30515495	30515495	+	Splice_Site	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:30515495G>A	ENST00000356798.6	+	18	2325		c.e18-1		ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Splice_Site	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)						blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	ATCACCCTCAGGTATGTGTTC	0.443000													33	47					0	0	1	0	0
WNT1	7471	broad.mit.edu	37	12	49375180	49375180	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:49375180C>A	ENST00000293549.3	+	4	906	c.870C>A	c.(868-870)gtC>gtA	p.V290V		NM_005430.3	NP_005421.1	P04628	WNT1_HUMAN	wingless-type MMTV integration site family, member 1	290					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(357;0.244)		ACGACCTCGTCTACTTCGAGA	0.697000													3	7					2.56e-06	2.81015e-06	1	1	0
GNL3L	54552	broad.mit.edu	37	X	54578402	54578402	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:54578402G>T	ENST00000336470.4	+	12	1315	c.1176G>T	c.(1174-1176)tgG>tgT	p.W392C	GNL3L_ENST00000360845.2_Missense_Mutation_p.W392C	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	392					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						TAGCTGACTGGGTGAGGTGAG	0.602000													10	14					2.17888e-05	2.34785e-05	1	1	0
WNT2B	7482	broad.mit.edu	37	1	113051931	113051931	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:113051931G>T	ENST00000369684.4	+	1	532	c.47G>T	c.(46-48)cGg>cTg	p.R16L	WNT2B_ENST00000256640.5_Intron|WNT2B_ENST00000369686.4_Intron	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B	16					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTCCCGCTTCGGCGCGCCAGC	0.751000													12	7					2.80697e-09	3.2645e-09	1	1	0
DMD	1756	broad.mit.edu	37	X	32834631	32834631	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:32834631T>A	ENST00000357033.4	-	6	690	c.484A>T	c.(484-486)Agc>Tgc	p.S162C	DMD_ENST00000378677.2_Missense_Mutation_p.S158C|DMD_ENST00000288447.4_Missense_Mutation_p.S154C	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	162	Actin-binding.|CH 2.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCAGACCAGCTGGTGGTGAAG	0.413000													27	77					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32328252	32328252	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:32328252C>A	ENST00000357033.4	-	42	6270	c.6064G>T	c.(6064-6066)Gac>Tac	p.D2022Y	DMD_ENST00000378677.2_Missense_Mutation_p.D2018Y	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2022					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCACAGAGGTCAGGAGCATTG	0.393000													34	55					4.3181e-19	5.90662e-19	1	1	0
PLEKHG5	57449	broad.mit.edu	37	1	6528448	6528448	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:6528448G>T	ENST00000377748.1	-	21	3176	c.2679C>A	c.(2677-2679)gaC>gaA	p.D893E	PLEKHG5_ENST00000544978.1_Missense_Mutation_p.D816E|PLEKHG5_ENST00000340850.5_Missense_Mutation_p.D816E|PLEKHG5_ENST00000400915.3_Missense_Mutation_p.D872E|PLEKHG5_ENST00000377737.2_Missense_Mutation_p.D816E|PLEKHG5_ENST00000400913.1_Missense_Mutation_p.D816E|PLEKHG5_ENST00000535355.1_Missense_Mutation_p.D885E|PLEKHG5_ENST00000377732.1_Missense_Mutation_p.D853E|PLEKHG5_ENST00000377725.1_Missense_Mutation_p.D816E|PLEKHG5_ENST00000537245.1_Missense_Mutation_p.D895E|PLEKHG5_ENST00000377740.3_Intron|PLEKHG5_ENST00000377728.3_Missense_Mutation_p.D816E	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	872					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CGTAGGCAGAGTCCATGGAGC	0.642000													6	5					0.0215528	0.0219265	1	1	0
PNKP	11284	broad.mit.edu	37	19	50370336	50370336	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:50370336C>A	ENST00000322344.3	-	2	235	c.126G>T	c.(124-126)acG>acT	p.T42T	PNKP_ENST00000596014.1_Silent_p.T42T|PNKP_ENST00000595792.1_5'UTR|PNKP_ENST00000600910.1_Silent_p.T42T|PNKP_ENST00000600573.1_Silent_p.T42T	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	42					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		ACTTCCGGTCCGTAACCTGGG	0.677000								Other BER factors					30	70					8.16721e-17	1.07538e-16	1	1	0
CD207	50489	broad.mit.edu	37	2	71061009	71061009	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:71061009C>T	ENST00000410009.3	-	3	378	c.333G>A	c.(331-333)atG>atA	p.M111I		NM_015717.3	NP_056532.3	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	111					defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						TCTCATTCACCATCTGGATCT	0.478000													13	49					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5076127	5076127	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:5076127G>A	ENST00000574788.1	+	38	6305	c.4075G>A	c.(4075-4077)Gac>Aac	p.D1359N	USP6_ENST00000332776.4_3'UTR|USP6_ENST00000304328.5_Missense_Mutation_p.D1042N|USP6_ENST00000250066.6_Missense_Mutation_p.D1359N			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	1359					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						AATTGACACCGACTCTGCCTA	0.428000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								47	54					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45924738	45924738	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr21:45924738A>T	ENST00000323084.4	-	11	1846	c.1781T>A	c.(1780-1782)gTg>gAg	p.V594E		NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	594					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						ATCTTCTCCCACCGAGAAAAA	0.532000													36	70					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11082866	11082866	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:11082866G>T	ENST00000304623.8	-	16	2919	c.2730C>A	c.(2728-2730)tgC>tgA	p.C910*	CTNND2_ENST00000503622.1_Nonsense_Mutation_p.C573*|CTNND2_ENST00000458100.2_Nonsense_Mutation_p.C477*|CTNND2_ENST00000511377.1_Nonsense_Mutation_p.C819*|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Nonsense_Mutation_p.C852*	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	910					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding	p.C910C(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGGCCACCGCGCACACCACAC	0.527000													26	71					1.33986e-20	1.88151e-20	1	1	0
KNTC1	9735	broad.mit.edu	37	12	123087383	123087383	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:123087383A>G	ENST00000333479.7	+	47	5010	c.4833A>G	c.(4831-4833)gaA>gaG	p.E1611E	KNTC1_ENST00000450485.2_Intron|KNTC1_ENST00000537348.1_Silent_p.E36E|KNTC1_ENST00000436959.3_5'UTR	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1611					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TAGCTACAGAACTCAGTGAAG	0.303000													21	56					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124335521	124335521	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:124335521C>A	ENST00000409039.3	+	34	5860	c.5835C>A	c.(5833-5835)ccC>ccA	p.P1945P		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1945	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CGGAGCTGCCCGAGTCGGTGA	0.607000													20	46					7.45023e-12	9.19093e-12	1	1	0
TRIM60	166655	broad.mit.edu	37	4	165961346	165961346	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:165961346G>A	ENST00000512596.1	+	3	338	c.122G>A	c.(121-123)aGt>aAt	p.S41N	TRIM60_ENST00000341062.5_Missense_Mutation_p.S41N|TRIM60_ENST00000508504.1_Missense_Mutation_p.S41N	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	41						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		TCCTGCCTCAGTGTATCCTGG	0.507000													38	79					0	0	1	0	0
TREX2	11219	broad.mit.edu	37	X	152710874	152710874	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:152710874G>T	ENST00000330912.2	-	13	1565	c.15C>A	c.(13-15)ccC>ccA	p.P5P	TREX2_ENST00000334497.2_Silent_p.P48P|TREX2_ENST00000370231.2_Silent_p.P5P|TREX2_ENST00000402951.1_Silent_p.P48P|TREX2_ENST00000338525.2_Silent_p.P5P|TREX2_ENST00000414588.1_Silent_p.P47P|TREX2_ENST00000370232.1_Silent_p.P48P|TREX2_ENST00000393862.2_Silent_p.P5P			Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	48					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(2)	11	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTCGGCCCGGGGTGCCTCGG	0.627000								Editing and processing nucleases					6	7					2.7689e-08	3.16445e-08	1	1	0
LAMB2	3913	broad.mit.edu	37	3	49158710	49158710	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:49158710G>A	ENST00000418109.1	-	33	5510	c.5346C>T	c.(5344-5346)agC>agT	p.S1782S	LAMB2_ENST00000305544.4_Silent_p.S1782S	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1782	Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTTGAAGCACGCTGCGCATCC	0.577000													3	37					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233675972	233675972	+	Silent	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:233675972T>C	ENST00000373566.3	+	18	2180	c.1983T>C	c.(1981-1983)gtT>gtC	p.V661V	GIGYF2_ENST00000409196.3_Silent_p.V633V|GIGYF2_ENST00000452341.2_Silent_p.V470V|GIGYF2_ENST00000373563.4_Silent_p.V639V|GIGYF2_ENST00000409451.3_Silent_p.V660V|GIGYF2_ENST00000409547.1_Silent_p.V639V|GIGYF2_ENST00000409480.1_Silent_p.V661V			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	639	Gln-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		ATGCACAGGTTTTGGCCCAAC	0.423000													13	39					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38907400	38907400	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:38907400G>T	ENST00000358869.2	+	6	751	c.575G>T	c.(574-576)gGc>gTc	p.G192V	FAM114A1_ENST00000515037.1_5'UTR	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	192						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						ACAGATCAGGGCCCTGCAGAA	0.488000													29	58					9.78485e-24	1.43511e-23	1	1	0
MUC16	94025	broad.mit.edu	37	19	8976318	8976318	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:8976318G>T	ENST00000397910.4	-	75	42713	c.42510C>A	c.(42508-42510)acC>acA	p.T14170T	MUC16_ENST00000380951.5_Silent_p.T811T|MUC16_ENST00000596956.1_Intron	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14201	SEA 14.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGACACCATGGGTCAGCTGAC	0.572000													16	11					3.99206e-14	5.14099e-14	1	1	0
KIF16B	55614	broad.mit.edu	37	20	16474977	16474977	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:16474977C>T	ENST00000354981.2	-	12	1418	c.1261G>A	c.(1261-1263)Gaa>Aaa	p.E421K	KIF16B_ENST00000408042.1_Missense_Mutation_p.E421K|KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000355755.3_Missense_Mutation_p.E421K	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	421					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TTTGTCCATTCCTTGGTCAAT	0.299000													6	31					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164384	34164384	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:34164384C>T	ENST00000373381.4	-	24	4070	c.3894G>A	c.(3892-3894)cgG>cgA	p.R1298R	CSMD2_ENST00000373380.1_Silent_p.R171R|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1258	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGTCCCAGGTCCGGCGCTCTC	0.597000													28	55					0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806221	97806221	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:97806221G>T	ENST00000358642.2	+	1	205	c.205G>T	c.(205-207)Gcc>Tcc	p.A69S		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						TGGTGGTTTAGCCTTTTCAGA	0.448000													101	128					9.47431e-33	1.44579e-32	1	1	0
MDN1	23195	broad.mit.edu	37	6	90438741	90438741	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:90438741C>A	ENST00000369393.3	-	36	5373	c.5258G>T	c.(5257-5259)gGt>gTt	p.G1753V	MDN1_ENST00000428876.1_Missense_Mutation_p.G1753V			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1753					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACCAGGGGAACCCTCCAGGAG	0.468000													27	62					1.06801e-11	1.31448e-11	1	1	0
CHST2	9435	broad.mit.edu	37	3	142840322	142840322	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:142840322G>A	ENST00000309575.3	+	2	2048	c.664G>A	c.(664-666)Gct>Act	p.A222T		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	222					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						CATGCTGAGCGCTCTTTACCG	0.627000													28	53					0	0	1	0	0
MGAT4A	11320	broad.mit.edu	37	2	99256616	99256616	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:99256616A>T	ENST00000393487.1	-	11	1409	c.1096T>A	c.(1096-1098)Tca>Aca	p.S366T	MGAT4A_ENST00000409391.1_Missense_Mutation_p.S366T|MGAT4A_ENST00000414521.2_Missense_Mutation_p.S238T|MGAT4A_ENST00000264968.2_Missense_Mutation_p.S366T	NM_012214.2	NP_036346.1	Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	366					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						GATAGTGATGAGTGCAGACCA	0.313000													13	39					0	0	1	0	0
HSH2D	84941	broad.mit.edu	37	19	16259679	16259679	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:16259679C>A	ENST00000593154.2	+	4	650	c.119C>A	c.(118-120)tCa>tAa	p.S40*	HSH2D_ENST00000253680.6_Nonsense_Mutation_p.S40*|HSH2D_ENST00000588246.1_Nonsense_Mutation_p.S40*|HSH2D_ENST00000397372.4_Intron	NM_032855.2	NP_116244.1	Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	40	SH2.					cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|large_intestine(2)	4						GGTGCAATCTCAAGAGAGTGA	0.612000													56	60					9.53978e-28	1.43097e-27	1	1	0
PHACTR4	65979	broad.mit.edu	37	1	28815703	28815703	+	Silent	SNP	A	A	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:28815703A>C	ENST00000373839.3	+	10	2043	c.1782A>C	c.(1780-1782)acA>acC	p.T594T	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Silent_p.T604T	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	594							actin binding|protein phosphatase inhibitor activity	p.T604T(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		AAAGACCAACACCAGAAGAAC	0.308000													9	36					0	0	1	0	0
C7orf66	154907	broad.mit.edu	37	7	108524212	108524212	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:108524212G>A	ENST00000379007.2	-	2	254	c.200C>T	c.(199-201)tCa>tTa	p.S67L		NM_001024607.1	NP_001019778.1	A4D0T2	CG066_HUMAN	chromosome 7 open reading frame 66	67						integral to membrane		p.S67*(1)		breast(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	15						ATATTGAGCTGAGAATTCCTC	0.423000													41	102					0	0	1	0	0
LRR1	122769	broad.mit.edu	37	14	50069115	50069115	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:50069115A>T	ENST00000298288.6	+	2	535	c.211A>T	c.(211-213)Acc>Tcc	p.T71S	LRR1_ENST00000557531.1_Intron|LRR1_ENST00000318317.4_Missense_Mutation_p.T71S	NM_152329.3	NP_689542.2	Q96L50	LLR1_HUMAN	leucine rich repeat protein 1	71										kidney(2)|large_intestine(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GCAATTCTTCACCAAATTTGT	0.323000													35	77					0	0	1	0	0
FPGT	8790	broad.mit.edu	37	1	74671308	74671308	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:74671308G>T	ENST00000370898.2	+	4	1614	c.1577G>T	c.(1576-1578)cGc>cTc	p.R526L	FPGT_ENST00000524915.1_Intron|FPGT_ENST00000534056.1_Missense_Mutation_p.R272L|FPGT-TNNI3K_ENST00000370895.1_Intron|FPGT-TNNI3K_ENST00000557284.1_Intron|FPGT-TNNI3K_ENST00000370899.3_Intron|TNNI3K_ENST00000370893.1_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT_ENST00000370894.4_3'UTR	NM_001199328.1|NM_003838.3	NP_001186257.1|NP_003829.2			fucose-1-phosphate guanylyltransferase									p.R526H(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						TGGACTGCACGCATTTTCCCA	0.388000													32	69					4.31634e-10	5.12141e-10	1	1	0
ITPKC	80271	broad.mit.edu	37	19	41223227	41223227	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:41223227G>T	ENST00000263370.2	+	1	220	c.187G>T	c.(187-189)Gag>Tag	p.E63*		NM_025194.2	NP_079470.1	Q96DU7	IP3KC_HUMAN	inositol-trisphosphate 3-kinase C	63						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	14			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ggcccggACAGAGGGGTCCAG	0.776000													5	12					0.014758	0.0151305	1	1	0
CDH11	1009	broad.mit.edu	37	16	65006894	65006894	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:65006894G>T	ENST00000394156.3	-	9	1756	c.1303C>A	c.(1303-1305)Cca>Aca	p.P435T	CDH11_ENST00000566827.1_Missense_Mutation_p.P309T|CDH11_ENST00000268603.4_Missense_Mutation_p.P435T			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	435	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCATCCTCTGGATTAATAGTG	0.413000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			29	11					4.59853e-10	5.444e-10	1	1	0
FAM19A5	25817	broad.mit.edu	37	22	49042466	49042466	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:49042466C>T	ENST00000358295.5	+	2	324	c.149C>T	c.(148-150)cCt>cTt	p.P50L	FAM19A5_ENST00000402357.1_Missense_Mutation_p.P57L|FAM19A5_ENST00000473898.1_Intron	NM_015381.5	NP_056196.2	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5	57						extracellular region|integral to membrane				large_intestine(1)|lung(6)	7		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		AGCAGCCAGCCTCGGAGGACG	0.672000													14	40					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117299172	117299172	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:117299172G>A	ENST00000321322.6	-	33	6215	c.6214C>T	c.(6214-6216)Cga>Tga	p.R2072*	DSCAML1_ENST00000527706.1_Nonsense_Mutation_p.R1802*	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2012					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCCCCGGCTCGTGGAGGCTCG	0.751000													27	15					0	0	1	0	0
PLAC1	10761	broad.mit.edu	37	X	133700553	133700553	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:133700553C>A	ENST00000359237.4	-	3	445	c.160G>T	c.(160-162)Gaa>Taa	p.E54*	PLAC1_ENST00000476971.1_5'UTR	NM_021796.3	NP_068568.1	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1	54					placenta development	extracellular region				large_intestine(4)|lung(1)|pancreas(1)	6	Acute lymphoblastic leukemia(192;0.000127)					AAGTGTAGTTCATGAAAGTGT	0.507000													47	120					8.86878e-18	1.19153e-17	1	1	0
NRG3	10718	broad.mit.edu	37	10	84733566	84733566	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:84733566C>A	ENST00000372142.2	+	8	918	c.644C>A	c.(643-645)cCt>cAt	p.P215H	NRG3_ENST00000404547.1_Missense_Mutation_p.P436H|NRG3_ENST00000556918.1_Missense_Mutation_p.P266H|NRG3_ENST00000545131.1_Missense_Mutation_p.P86H|NRG3_ENST00000404576.2_Missense_Mutation_p.P240H|NRG3_ENST00000372141.2_Missense_Mutation_p.P436H|NRG3_ENST00000537893.1_Missense_Mutation_p.P86H	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	436	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAAAGGCATCCTGTGACTGCA	0.483000													29	53					6.00712e-18	8.11192e-18	1	1	0
ITGA4	3676	broad.mit.edu	37	2	182322446	182322446	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:182322446T>C	ENST00000397033.2	+	1	495	c.65T>C	c.(64-66)cTg>cCg	p.L22P	ITGA4_ENST00000339307.4_Missense_Mutation_p.L22P	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	22					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ACGGTGATGCTGTTGCTGTGC	0.672000													4	15					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032484	142032484	+	RNA	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:142032484C>A	ENST00000547918.2	+	0	337																											CCAGCGCACACAGCAGGGGGA	0.562000													8	22					1.12685e-05	1.21922e-05	1	1	0
WBP11P1	441818	broad.mit.edu	37	18	30093455	30093455	+	RNA	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr18:30093455G>C	ENST00000567636.1	+	0	1830					NR_003558.1																						TTGATTCAGCGATCCAAGGTA	0.532000													114	54					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993692	140993692	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:140993692A>T	ENST00000285879.4	+	4	788	c.502A>T	c.(502-504)Agc>Tgc	p.S168C	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	168							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GATTCCTGTGAGCGCCGCCTC	0.483000										HNSCC(15;0.026)			42	121					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52724235	52724235	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:52724235A>G	ENST00000322088.6	+	12	1425	c.1367A>G	c.(1366-1368)tAt>tGt	p.Y456C	PPP2R1A_ENST00000462990.1_Missense_Mutation_p.Y277C|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.Y401C	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	456	PP2A subunit C binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TCTGCAGTATATGCCATCCGC	0.532000			Mis		clear cell ovarian carcinoma								29	49					0	0	1	0	0
LANCL3	347404	broad.mit.edu	37	X	37526718	37526718	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:37526718C>A	ENST00000378621.3	+	4	1381	c.1079C>A	c.(1078-1080)tCt>tAt	p.S360Y	TM4SF2_ENST00000465127.1_Intron|LANCL3_ENST00000378619.3_Missense_Mutation_p.S360Y	NM_198511.2	NP_940913.1	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3 (bacterial)	360							catalytic activity			lung(4)|pancreas(1)	5						ACGGGAAACTCTAAATACATC	0.418000													16	26					6.94344e-10	8.14697e-10	1	1	0
PLCD4	84812	broad.mit.edu	37	2	219486264	219486264	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:219486264G>T	ENST00000450993.2	+	5	821	c.482G>T	c.(481-483)cGg>cTg	p.R161L	PLCD4_ENST00000432688.1_Missense_Mutation_p.R161L|PLCD4_ENST00000417849.1_Missense_Mutation_p.R161L	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	161	EF-hand 1.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GAAGTTCAGCGGTTATTGCAC	0.463000													72	174					1.49552e-23	2.18736e-23	1	1	0
CROCCP2	84809	broad.mit.edu	37	1	16945358	16945358	+	RNA	SNP	G	G	C	rs945905	by1000genomes	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:16945358G>C	ENST00000412962.1	-	0	2161																											AGTAGGAGAAGAGAGAGGAAG	0.567000													3	25					0	0	1	0	0
EMC2	9694	broad.mit.edu	37	8	109462140	109462140	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:109462140A>G	ENST00000220853.3	+	2	164	c.129A>G	c.(127-129)gaA>gaG	p.E43E		NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2																		TAATTAATGAATATGCTTCTA	0.313000													25	49					0	0	1	0	0
IRF1	3659	broad.mit.edu	37	5	131819709	131819709	+	Silent	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:131819709G>C	ENST00000245414.4	-	10	1170	c.912C>G	c.(910-912)acC>acG	p.T304T	IRF1_ENST00000405885.2_Silent_p.T304T	NM_002198.2	NP_002189.1	P10914	IRF1_HUMAN	interferon regulatory factor 1	304					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		TGTCCAGCCAGGTGGCATCCA	0.577000													15	38					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133219562	133219562	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:133219562G>A	ENST00000320574.5	-	36	4615	c.4572C>T	c.(4570-4572)ccC>ccT	p.P1524P	POLE_ENST00000535270.1_Silent_p.P1497P	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1524					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CGCCAAGGCTGGGCATCTGGT	0.672000								DNA polymerases (catalytic subunits)					3	30					0	0	1	0	0
KLF7	8609	broad.mit.edu	37	2	207988812	207988812	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:207988812G>A	ENST00000309446.6	-	2	795	c.419C>T	c.(418-420)tCg>tTg	p.S140L	KLF7_ENST00000412414.2_Missense_Mutation_p.S112L|KLF7_ENST00000467833.1_Intron|KLF7_ENST00000458272.1_Intron|KLF7_ENST00000421199.1_Missense_Mutation_p.S107L|KLF7_ENST00000423015.1_Missense_Mutation_p.S140L	NM_003709.3	NP_003700.1	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	140					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(3)|liver(1)|lung(4)|skin(1)	11				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		CTCAGGGGACGATGGGGGCGT	0.597000													26	50					0	0	1	0	0
NUDT12	83594	broad.mit.edu	37	5	102888111	102888111	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:102888111G>T	ENST00000230792.2	-	6	1181	c.1085C>A	c.(1084-1086)aCa>aAa	p.T362K	NUDT12_ENST00000507423.1_Missense_Mutation_p.T344K	NM_031438.2	NP_113626.1	Q9BQG2	NUD12_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 12	362	Nudix hydrolase.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity			endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|urinary_tract(1)	12		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		ATCTTCTATTGTCTCTCCTAA	0.443000													17	39					6.94344e-10	8.14697e-10	1	1	0
SYCP2L	221711	broad.mit.edu	37	6	10931680	10931680	+	Silent	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:10931680A>T	ENST00000283141.6	+	20	1937	c.1641A>T	c.(1639-1641)ccA>ccT	p.P547P		NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	547						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TAGTCTTGCCAGTTTTCCCTC	0.398000													21	59					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22836738	22836738	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:22836738G>A	ENST00000456783.2	+	3	295	c.51G>A	c.(49-51)aaG>aaA	p.K17K		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				CTGCCTCTAAGCCAGACCTGA	0.403000													43	73					0	0	1	0	0
SLC5A4	6527	broad.mit.edu	37	22	32633238	32633238	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:32633238C>T	ENST00000266086.4	-	7	668	c.657G>A	c.(655-657)atG>atA	p.M219I	RP1-90G24.10_ENST00000434942.1_RNA	NM_014227.2	NP_055042.1	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (glucose activated ion channel), member 4	219					carbohydrate transport|sodium ion transport	integral to membrane	symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|pancreas(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TACCAAACCCCATGAGAATAA	0.512000													5	13					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1480884	1480884	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:1480884G>A	ENST00000345913.4	+	8	937	c.846G>A	c.(844-846)gcG>gcA	p.A282A	TPO_ENST00000337415.3_Silent_p.A282A|TPO_ENST00000382201.3_Silent_p.A282A|TPO_ENST00000497517.2_Intron|TPO_ENST00000382198.1_Intron|TPO_ENST00000329066.4_Silent_p.A282A|TPO_ENST00000349624.3_Intron|TPO_ENST00000346956.3_Silent_p.A282A	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	282					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGCCGGCCGCGGGCACCGCCT	0.701000													7	8					0	0	1	0	0
GPC4	2239	broad.mit.edu	37	X	132548993	132548993	+	Translation_Start_Site	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:132548993T>C	ENST00000370828.3	-	1	525	c.1A>G	c.(1-3)Atg>Gtg	p.M1V		NM_001448.2	NP_001439.2	O75487	GPC4_HUMAN	glypican 4	1					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;0.000127)					AACCGTGCCATGGTGCGGGCC	0.706000													12	29					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29393882	29393882	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:29393882C>A	ENST00000558402.1	+	11	2018	c.1419C>A	c.(1417-1419)cgC>cgA	p.R473R	APBA2_ENST00000558330.1_Silent_p.R461R|APBA2_ENST00000558259.1_Silent_p.R473R|APBA2_ENST00000411764.1_Silent_p.R461R|APBA2_ENST00000561069.1_Silent_p.R473R			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	473	PID.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TGGCCAGACGCCGCATGCCCC	0.587000													29	9					7.38237e-10	8.62365e-10	1	1	0
ZC3H11A	9877	broad.mit.edu	37	1	203819770	203819770	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:203819770C>T	ENST00000545588.1	+	15	5894	c.2067C>T	c.(2065-2067)agC>agT	p.S689S	ZC3H11A_ENST00000367214.1_Silent_p.S689S|ZC3H11A_ENST00000332127.4_Silent_p.S689S|ZC3H11A_ENST00000367210.1_Silent_p.S689S|ZC3H11A_ENST00000367212.3_Silent_p.S689S	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	689							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCAGCTCCAGCAGTGTCCTAC	0.498000													29	39					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28598309	28598309	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:28598309G>C	ENST00000253063.3	+	3	602	c.281G>C	c.(280-282)tGg>tCg	p.W94S		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	94					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		ACCAGCTTCTGGCGCCTGCAC	0.617000													27	44					0	0	1	0	0
LAMP2	3920	broad.mit.edu	37	X	119575685	119575685	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:119575685G>T	ENST00000371335.4	-	8	1129	c.993C>A	c.(991-993)tgC>tgA	p.C331*	LAMP2_ENST00000540603.1_Nonsense_Mutation_p.C284*|LAMP2_ENST00000200639.4_Nonsense_Mutation_p.C331*|LAMP2_ENST00000434600.2_Nonsense_Mutation_p.C331*|LAMP2_ENST00000538785.1_Nonsense_Mutation_p.C220*	NM_013995.2	NP_054701.1	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2	331	Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				endometrium(4)|large_intestine(2)|lung(5)|ovary(2)|urinary_tract(2)	15						GCTCTTTGTTGCACATATAAG	0.393000													21	56					8.10497e-08	9.18332e-08	1	1	0
ASPM	259266	broad.mit.edu	37	1	197072043	197072043	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:197072043A>T	ENST00000367409.4	-	18	6594	c.6338T>A	c.(6337-6339)aTt>aAt	p.I2113N	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	2113	IQ 16.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CATGTGTTGAATATGTCTTCT	0.313000													64	91					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94918607	94918607	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:94918607T>C	ENST00000536441.1	-	5	911	c.575A>G	c.(574-576)cAt>cGt	p.H192R	SESN3_ENST00000278499.2_Missense_Mutation_p.H53R|RP11-712B9.2_ENST00000534864.1_RNA|RP11-712B9.2_ENST00000534891.1_RNA|SESN3_ENST00000393234.1_Missense_Mutation_p.H192R|SESN3_ENST00000416495.2_Missense_Mutation_p.H192R	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	192					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		GACCACAGCATGTACCAGTTC	0.388000													85	35					0	0	1	0	0
NCL	4691	broad.mit.edu	37	2	232320299	232320299	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:232320299G>A	ENST00000322723.4	-	13	2109	c.1869C>T	c.(1867-1869)gcC>gcT	p.A623A		NM_005381.2	NP_005372.2	P19338	NUCL_HUMAN	nucleolin	623	RRM 4.			Missing (in Ref. 2; AAA59954).	angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		TGGCAGCTTTGGCATCCTCCT	0.463000													65	135					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	113965829	113965829	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:113965829C>T	ENST00000276198.1	+	4	890	c.162C>T	c.(160-162)aaC>aaT	p.N54N	HTR2C_ENST00000371951.1_Silent_p.N54N|HTR2C_ENST00000371950.3_Silent_p.N54N	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	54					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	GGGTACAAAACTGGCCAGCAC	0.438000													54	97					0	0	1	0	0
GC	2638	broad.mit.edu	37	4	72629207	72629207	+	Nonsense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:72629207T>A	ENST00000273951.8	-	6	962	c.619A>T	c.(619-621)Aaa>Taa	p.K207*	GC_ENST00000513476.1_Nonsense_Mutation_p.K207*|GC_ENST00000503472.1_5'UTR|GC_ENST00000504199.1_Nonsense_Mutation_p.K226*	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	207	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GATAAATGTTTAAGCTGGAGT	0.353000													19	25					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55979531	55979531	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:55979531T>C	ENST00000263923.4	-	7	1211	c.916A>G	c.(916-918)Acc>Gcc	p.T306A		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	306	Ig-like C2-type 3.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GCTGCACAGGTGTACAATCCT	0.453000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			39	77					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107332101	107332101	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:107332101A>G	ENST00000335040.1	+	1	653	c.653A>G	c.(652-654)tAc>tGc	p.Y218C		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						TCCATCTCTTACATATTTATT	0.398000													36	39					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11903566	11903566	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:11903566G>A	ENST00000405977.1	+	5	1446	c.821G>A	c.(820-822)cGt>cAt	p.R274H	BTBD3_ENST00000399006.2_Missense_Mutation_p.R213H|BTBD3_ENST00000378226.2_Missense_Mutation_p.R274H|BTBD3_ENST00000254977.3_Missense_Mutation_p.R213H|BTBD3_ENST00000488503.1_3'UTR			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	274										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						AGTATTCTCCGTAGGGAAACT	0.478000													28	61					0	0	1	0	0
SLC12A1	6557	broad.mit.edu	37	15	48527167	48527167	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:48527167T>C	ENST00000396577.3	+	9	1396	c.1181T>C	c.(1180-1182)aTt>aCt	p.I394T	SLC12A1_ENST00000558405.1_Missense_Mutation_p.I394T|SLC12A1_ENST00000330289.6_Missense_Mutation_p.I394T|SLC12A1_ENST00000380993.3_Missense_Mutation_p.I394T	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	394					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GCTACTGGGATTCTTGCTGGT	0.488000													66	44					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70387194	70387194	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:70387194G>A	ENST00000374051.3	+	6	1509	c.1187G>A	c.(1186-1188)gGg>gAg	p.G396E	NLGN3_ENST00000358741.3_Missense_Mutation_p.G416E|NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Missense_Mutation_p.G376E	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	416					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					TTTGTGGAAGGGGTGGTGGAC	0.517000													25	58					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142627469	142627469	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:142627469G>C	ENST00000265310.1	-	2	549	c.201C>G	c.(199-201)gaC>gaG	p.D67E	TRPV5_ENST00000442623.1_Missense_Mutation_p.D67E	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	67					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CACAGGTGCAGTCCAGTAGAA	0.502000													19	69					0	0	1	0	0
MLN	4295	broad.mit.edu	37	6	33766918	33766918	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:33766918C>T	ENST00000430124.2	-	3	263	c.198G>A	c.(196-198)gcG>gcA	p.A66A	MLN_ENST00000507738.1_Silent_p.A66A|MLN_ENST00000266003.5_Silent_p.A66A	NM_001040109.1|NM_001184698.1|NM_002418.2	NP_001035198.1|NP_001171627.1|NP_002409.1	P12872	MOTI_HUMAN	motilin	66					cell-cell signaling|G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	hormone activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|skin(1)	6						TGATGGGCTCCGCAGGGTCTA	0.517000													32	63					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72520125	72520125	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:72520125G>T	ENST00000373208.1	+	22	3197	c.3197G>T	c.(3196-3198)tGc>tTc	p.C1066F	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.C1063F	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	1063	PLAC.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GCGGAGCCCTGCACGGGAGAC	0.607000													20	45					5.03518e-11	6.05598e-11	1	1	0
FAM47C	442444	broad.mit.edu	37	X	37027084	37027084	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:37027084G>T	ENST00000358047.3	+	1	653	c.601G>T	c.(601-603)Gag>Tag	p.E201*		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	201										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCTCCCCCCGGAGCCTCCCAA	0.637000													11	53					1.08611e-07	1.21755e-07	1	1	0
FCRL5	83416	broad.mit.edu	37	1	157514068	157514068	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:157514068G>T	ENST00000361835.3	-	5	985	c.828C>A	c.(826-828)tcC>tcA	p.S276S	FCRL5_ENST00000368190.3_Silent_p.S276S|FCRL5_ENST00000368189.3_Silent_p.S276S|FCRL5_ENST00000368191.3_Silent_p.S191S|FCRL5_ENST00000356953.4_Silent_p.S276S	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	276						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CCTGTATCCAGGATCTCGGGC	0.507000													88	174					9.47799e-51	1.49832e-50	1	1	0
ZNF546	339327	broad.mit.edu	37	19	40521452	40521452	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:40521452C>A	ENST00000347077.4	+	7	2491	c.2275C>A	c.(2275-2277)Cgt>Agt	p.R759S	ZNF546_ENST00000600094.1_Missense_Mutation_p.R733S|ZNF546_ENST00000596894.1_Intron	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	759					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GAATGCCTTTCGTCTTCAAGC	0.393000													28	51					7.38237e-10	8.62365e-10	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139155283	139155283	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:139155283A>G	ENST00000395297.1	-	16	3780	c.3610T>C	c.(3610-3612)Ttg>Ctg	p.L1204L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1204										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGGTTGTACAACTGAATGTGT	0.418000										HNSCC(54;0.14)			18	45					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794191	140794191	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:140794191G>T	ENST00000398610.2	+	1	1449	c.1449G>T	c.(1447-1449)ccG>ccT	p.P483P	PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGGACCCGGACAGCAAAG	0.517000													39	85					3.61848e-18	4.91146e-18	1	1	0
MRGPRD	116512	broad.mit.edu	37	11	68747753	68747753	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:68747753G>A	ENST00000309106.3	-	1	702	c.703C>T	c.(703-705)Ctg>Ttg	p.L235L		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	235						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTCAGAGGCAGGGAACAGATG	0.617000													16	23					0	0	1	0	0
IL22	50616	broad.mit.edu	37	12	68647192	68647192	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:68647192T>G	ENST00000538666.1	-	2	107	c.37A>C	c.(37-39)Atg>Ctg	p.M13L	IL22_ENST00000328087.4_Missense_Mutation_p.M13L			Q9GZX6	IL22_HUMAN	interleukin 22	13					acute-phase response	extracellular space	cytokine activity|interleukin-22 receptor binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)	14		Myeloproliferative disorder(1001;0.0255)	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)		AGGGTCCCCATAAGGAAAGAG	0.572000													24	43					0	0	1	0	0
ALPP	250	broad.mit.edu	37	2	233246339	233246339	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:233246339C>T	ENST00000392027.2	+	11	1711	c.1442C>T	c.(1441-1443)gCg>gTg	p.A481V	AC068134.8_ENST00000441266.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	481						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		ACCTTCATAGCGCACGTCATG	0.746000													9	14					0	0	1	0	0
FAM83E	54854	broad.mit.edu	37	19	49116530	49116530	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:49116530C>G	ENST00000263266.3	-	1	289	c.100G>C	c.(100-102)Gca>Cca	p.A34P		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	34										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GCCTCCAGTGCCAGCCGCTGG	0.687000													8	13					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477334	110477334	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:110477334C>A	ENST00000378402.5	+	49	8377	c.8273C>A	c.(8272-8274)tCc>tAc	p.S2758Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2758					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGAGTGACATCCATCTCTGGA	0.483000										HNSCC(38;0.096)			28	58					2.65835e-16	3.47427e-16	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	80101281	80101281	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:80101281C>T	ENST00000466387.1	+	10	1389	c.665C>T	c.(664-666)aCg>aTg	p.T222M	CTNNA2_ENST00000361291.4_Missense_Mutation_p.T256M|CTNNA2_ENST00000496558.1_Missense_Mutation_p.T222M|CTNNA2_ENST00000402739.4_Missense_Mutation_p.T222M|CTNNA2_ENST00000541047.1_Missense_Mutation_p.T222M|CTNNA2_ENST00000540488.1_Missense_Mutation_p.T222M			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	222					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						ATGCTGTACACGGCCTCTCAA	0.557000													23	37					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413800	72413800	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:72413800G>T	ENST00000395270.1	+	14	3514	c.2473G>T	c.(2473-2475)Ggc>Tgc	p.G825C	POM121_ENST00000358357.3_Missense_Mutation_p.G825C|POM121_ENST00000446813.1_Missense_Mutation_p.G825C|POM121_ENST00000434423.2_Missense_Mutation_p.G1090C|POM121_ENST00000257622.4_Missense_Mutation_p.G825C	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1090	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CTCGGTGTTTGGCAGCACAAC	0.647000													19	28					1.85244e-09	2.15914e-09	1	1	0
IGKV1-12	28940	broad.mit.edu	37	2	89339969	89339969	+	RNA	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:89339969C>A	ENST00000480492.1	-	0	149																											CCTACAGATGCAGACACGGAA	0.478000													89	143					2.16659e-41	3.40464e-41	1	1	0
CCDC171	203238	broad.mit.edu	37	9	15971674	15971674	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:15971674G>T	ENST00000380701.3	+	26	4149	c.3821G>T	c.(3820-3822)gGt>gTt	p.G1274V	CCDC171_ENST00000486641.2_Intron	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	1274																	GACACAACTGGTATTGGGGAT	0.373000													46	66					2.9001e-28	4.37501e-28	1	1	0
NKX2-2	4821	broad.mit.edu	37	20	21494104	21494104	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:21494104G>T	ENST00000377142.4	-	1	560	c.204C>A	c.(202-204)agC>agA	p.S68R		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	68					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						GGTTGTCGCTGCTGTCGTAGA	0.677000													14	43					6.72482e-11	8.06979e-11	1	1	0
CHIA	27159	broad.mit.edu	37	1	111862020	111862020	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:111862020C>T	ENST00000369740.1	+	11	1210	c.1107C>T	c.(1105-1107)ggC>ggT	p.G369G	CHIA_ENST00000343320.6_Silent_p.G369G|CHIA_ENST00000353665.6_Silent_p.G208G|CHIA_ENST00000483391.1_Silent_p.G208G|CHIA_ENST00000451398.2_Silent_p.G208G|RP5-1125M8.2_ENST00000426321.1_RNA|CHIA_ENST00000430615.1_Silent_p.G261G	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	369					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		ACTTCACTGGCACTTTCTGCA	0.512000													26	21					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34099403	34099403	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:34099403G>T	ENST00000397527.1	+	35	7997	c.7277G>T	c.(7276-7278)gGg>gTg	p.G2426V	CEP250_ENST00000342580.4_Missense_Mutation_p.G2370V	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2426					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			ACATCCCCAGGGCCAGTCCTG	0.627000													17	34					1.62849e-17	2.16041e-17	1	1	0
NHS	4810	broad.mit.edu	37	X	17743618	17743618	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:17743618C>G	ENST00000380060.3	+	6	1667	c.1329C>G	c.(1327-1329)atC>atG	p.I443M	NHS_ENST00000398097.3_Missense_Mutation_p.I287M	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	443						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					GAAGGAGAATCAGAGCTCAAA	0.507000													70	192					0	0	1	0	0
DDO	8528	broad.mit.edu	37	6	110714093	110714093	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:110714093T>C	ENST00000368924.3	-	5	1010	c.995A>G	c.(994-996)tAt>tGt	p.Y332C	DDO_ENST00000368923.3_Missense_Mutation_p.Y273C|DDO_ENST00000368925.1_Missense_Mutation_p.Y304C	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	304					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		CCCATGGCCATAGTGGTGGAC	0.642000													30	67					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10756082	10756082	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:10756082C>A	ENST00000416569.2	-	3	1332	c.1306G>T	c.(1306-1308)Ggg>Tgg	p.G436W	XKR6_ENST00000304437.2_Missense_Mutation_p.G157W	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	436						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CGAGTCCGCCCTTCCTTGACG	0.478000													29	30					3.57733e-08	4.07075e-08	1	1	0
SEC14L3	266629	broad.mit.edu	37	22	30867939	30867939	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:30867939C>A	ENST00000215812.4	-	1	97	c.7G>T	c.(7-9)Ggc>Tgc	p.G3C	SEC14L3_ENST00000403066.1_5'UTR|SEC14L3_ENST00000401751.1_5'UTR|SEC14L3_ENST00000539629.1_5'UTR|SEC14L3_ENST00000402286.1_5'UTR	NM_174975.4	NP_777635.1	Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	3						integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	CCAACTCGGCCGCTCATGGTG	0.642000													26	58					4.06085e-26	6.0398e-26	1	1	0
COL6A6	131873	broad.mit.edu	37	3	130313165	130313165	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:130313165C>A	ENST00000358511.6	+	17	4542	c.4511C>A	c.(4510-4512)gCa>gAa	p.A1504E	COL6A6_ENST00000453409.2_Missense_Mutation_p.A1504E	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1504	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GACCGTGGAGCAAAGGGCCTG	0.458000													34	40					8.16277e-20	1.13122e-19	1	1	0
KIAA0100	9703	broad.mit.edu	37	17	26960084	26960084	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:26960084G>A	ENST00000528896.2	-	20	3755	c.3681C>T	c.(3679-3681)gtC>gtT	p.V1227V	KIAA0100_ENST00000389003.3_Silent_p.V1084V|KIAA0100_ENST00000544884.1_Silent_p.V1084V	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1227						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CCCGCAGAGTGACACTATGGT	0.587000													15	40					0	0	1	0	0
WDR78	79819	broad.mit.edu	37	1	67327892	67327892	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:67327892C>A	ENST00000371026.3	-	7	1089	c.1034G>T	c.(1033-1035)aGt>aTt	p.S345I	WDR78_ENST00000371023.3_Missense_Mutation_p.S345I|WDR78_ENST00000493572.1_5'UTR|WDR78_ENST00000431318.1_Missense_Mutation_p.S91I	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	345										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						ATTTGCTTTACTACTTGACTC	0.338000													27	54					7.76418e-22	1.11097e-21	1	1	0
CROCC	9696	broad.mit.edu	37	1	17263238	17263238	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:17263238G>C	ENST00000375541.5	+	9	1132	c.1063G>C	c.(1063-1065)Gca>Cca	p.A355P	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	355					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCGGGCCGAGGCAGCCCTGGA	0.697000													3	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179436520	179436520	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:179436520C>A	ENST00000589042.1	-	326	74563	c.74339G>T	c.(74338-74340)cGa>cTa	p.R24780L	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R23139L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R15715L|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R15907L|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R15840L|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R22212L|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23139	Fibronectin type-III 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACATCTTCTCGGCAGGCGTC	0.418000													46	84					1.00776e-21	1.43422e-21	1	1	0
TECPR2	9895	broad.mit.edu	37	14	102901536	102901536	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:102901536C>T	ENST00000359520.7	+	9	2608	c.2382C>T	c.(2380-2382)ctC>ctT	p.L794L	TECPR2_ENST00000558678.1_Silent_p.L794L	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	794							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CCGGGCTGCTCAAGCCAGATC	0.532000													33	64					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22664458	22664458	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr21:22664458G>T	ENST00000400546.1	+	5	765	c.516G>T	c.(514-516)caG>caT	p.Q172H	NCAM2_ENST00000535285.1_Missense_Mutation_p.Q197H|NCAM2_ENST00000486367.1_3'UTR|NCAM2_ENST00000284894.7_Missense_Mutation_p.Q30H	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	172	Ig-like C2-type 2.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ATAACCTGCAGATTCTCAACA	0.393000													22	66					1.22574e-08	1.41e-08	1	1	0
CROCCP2	84809	broad.mit.edu	37	1	16946376	16946376	+	RNA	SNP	G	G	A	rs12086176		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:16946376G>A	ENST00000412962.1	-	0	1143																											GGAGGCCCTCGTCATGCTCCT	0.657000													3	34					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202900296	202900296	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:202900296T>C	ENST00000286201.1	+	1	987	c.926T>C	c.(925-927)cTa>cCa	p.L309P		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	309					axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						GGCTTCCTTCTAGAGGACCGC	0.652000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	153					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216405295	216405295	+	Splice_Site	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:216405295C>G	ENST00000366943.2	-	14	3379	c.2993_splice	c.e14+1	p.R998_splice	USH2A_ENST00000366942.3_Splice_Site_p.R998_splice|USH2A_ENST00000307340.3_Splice_Site_p.R998_splice			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	998	Laminin EGF-like 9.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAAGATGTACCTTCCAGTCTG	0.363000										HNSCC(13;0.011)			39	94					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2049841	2049841	+	Missense_Mutation	SNP	G	G	A	rs147389225	by1000genomes	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:2049841G>A	ENST00000563630.1	-	9	1786	c.1544C>T	c.(1543-1545)aCg>aTg	p.T515M	ZNF598_ENST00000562103.1_Missense_Mutation_p.T515M|ZNF598_ENST00000431526.1_Missense_Mutation_p.T570M			Q86UK7	ZN598_HUMAN	zinc finger protein 598	570						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						GACGGAGCCCGTGGGGCGTGT	0.662000													6	18					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031424	79031424	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:79031424A>C	ENST00000446378.2	+	2	6867	c.6836A>C	c.(6835-6837)aAa>aCa	p.K2279T		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2279						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAACAGCCAAAATTCATTTCT	0.358000													24	53					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138739295	138739295	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:138739295C>G	ENST00000329447.5	-	1	473	c.209G>C	c.(208-210)cGt>cCt	p.R70P	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	70										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAGGGGCACACGCAGGGCACA	0.706000													14	21					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32472928	32472928	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:32472928A>T	ENST00000357033.4	-	26	3660	c.3454T>A	c.(3454-3456)Ttg>Atg	p.L1152M	DMD_ENST00000378677.2_Missense_Mutation_p.L1148M	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1152					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCTCCCTTCAAGGCCTCCTTT	0.368000													14	61					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860607	26860607	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:26860607C>T	ENST00000398145.2	-	11	1605	c.989G>A	c.(988-990)gGc>gAc	p.G330D	HPS4_ENST00000402105.3_Missense_Mutation_p.G325D|HPS4_ENST00000398141.1_Missense_Mutation_p.G343D|HPS4_ENST00000336873.5_Missense_Mutation_p.G330D	NM_022081.4	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	330					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						CAGATCATGGCCAGACAAGCA	0.592000									Hermansky-Pudlak syndrome				27	71					0	0	1	0	0
CROT	54677	broad.mit.edu	37	7	86998753	86998753	+	Silent	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:86998753T>C	ENST00000331536.3	+	7	794	c.609T>C	c.(607-609)ttT>ttC	p.F203F	CROT_ENST00000442291.1_Silent_p.F203F|CROT_ENST00000419147.2_Silent_p.F231F	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	203					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	CTTTTGTCTTTGATGTAATAC	0.433000													51	104					0	0	1	0	0
OFD1	8481	broad.mit.edu	37	X	13774855	13774855	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:13774855G>C	ENST00000380567.1	+	14	1832	c.960G>C	c.(958-960)gaG>gaC	p.E320D	OFD1_ENST00000490265.1_3'UTR|OFD1_ENST00000340096.6_Missense_Mutation_p.E460D|OFD1_ENST00000380550.3_Missense_Mutation_p.E420D			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	460					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						AACTGGAAGAGAGTAGAAATG	0.328000													56	90					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92928043	92928043	+	Silent	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:92928043C>G	ENST00000373079.3	-	1	524	c.261G>C	c.(259-261)gcG>gcC	p.A87A	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	87					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						GGGCCCGCCGCGCCCTTCTGG	0.577000													4	25					0	0	1	0	0
SLC30A9	10463	broad.mit.edu	37	4	41992714	41992714	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:41992714T>G	ENST00000264451.6	+	1	226	c.46T>G	c.(46-48)Tcc>Gcc	p.S16A		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	16					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATGTAGCTGGTCCTCCCTGTG	0.716000													17	30					0	0	1	0	0
CCNH	902	broad.mit.edu	37	5	86690840	86690840	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:86690840C>T	ENST00000508855.1	-	7	784	c.732G>A	c.(730-732)atG>atA	p.M244I	CCNH_ENST00000256897.4_Intron|CCNH_ENST00000504878.1_Intron			P51946	CCNH_HUMAN	cyclin H	0					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(2)|ovary(2)	15		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		ACTTAGAGTTCATCTTTGGAG	0.328000								Direct reversal of damage;Direct reversal of damage;Nucleotide excision repair (NER)					46	63					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187521515	187521515	+	Splice_Site	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:187521515C>A	ENST00000441802.2	-	22	11850		c.e22-1			NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CATGATGAATCTAGGATAAAA	0.468000										HNSCC(5;0.00058)			8	7					0.000274275	0.000287907	1	1	0
FAM71F1	84691	broad.mit.edu	37	7	128355704	128355704	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:128355704T>A	ENST00000315184.5	+	1	262	c.209T>A	c.(208-210)cTg>cAg	p.L70Q	FAM71F1_ENST00000469348.1_Intron|FAM71F1_ENST00000485070.1_Intron	NM_032599.2	NP_115988.1	Q96KD3	F71F1_HUMAN	family with sequence similarity 71, member F1	70										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18						GAATTCAACCTGTTTCTTGAC	0.527000													25	58					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124382135	124382135	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:124382135C>T	ENST00000287394.5	-	7	964	c.857G>A	c.(856-858)gGa>gAa	p.G286E	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ctcttcttctccatcttcttc	0.368000													5	67					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67800073	67800073	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr13:67800073C>G	ENST00000544246.1	-	2	3191	c.2500G>C	c.(2500-2502)Gtt>Ctt	p.V834L	PCDH9_ENST00000377865.2_Missense_Mutation_p.V834L|PCDH9_ENST00000328454.5_Missense_Mutation_p.V834L|PCDH9_ENST00000456367.1_Missense_Mutation_p.V834L|PCDH9_ENST00000377861.3_Missense_Mutation_p.V834L	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	834					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CGCACCAGAACGGTGACGAAG	0.502000													34	41					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111078166	111078166	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:111078166A>G	ENST00000262839.2	-	7	2797	c.1879T>C	c.(1879-1881)Tcc>Ccc	p.S627P		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	627					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGCTGATAGGAGTTGTTCATC	0.443000													55	152					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122646772	122646772	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:122646772C>T	ENST00000195173.4	-	8	1018	c.715G>A	c.(715-717)Gct>Act	p.A239T	SEMA5B_ENST00000451055.2_Missense_Mutation_p.A293T|SEMA5B_ENST00000357599.3_Missense_Mutation_p.A239T			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	239	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GAGATGACAGCTGTGGAGTTG	0.627000													25	74					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119669722	119669722	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:119669722G>C	ENST00000371322.5	-	16	2184	c.2123C>G	c.(2122-2124)aCc>aGc	p.T708S	CUL4B_ENST00000336592.6_Missense_Mutation_p.T713S|CUL4B_ENST00000404115.3_Missense_Mutation_p.T726S	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	726					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GTGTCCTAGGGTTGACTGCCA	0.348000													40	129					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202626021	202626021	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:202626021G>A	ENST00000264276.6	-	4	1068	c.696C>T	c.(694-696)tgC>tgT	p.C232C	ALS2_ENST00000467448.1_Silent_p.C232C	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	232					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						TGCACTGGTTGCATCGTTCTG	0.493000													4	89					0	0	1	0	0
NR1H2	7376	broad.mit.edu	37	19	50881478	50881478	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:50881478A>G	ENST00000253727.5	+	5	489	c.254A>G	c.(253-255)gAg>gGg	p.E85G	NR1H2_ENST00000593926.1_Missense_Mutation_p.E85G|NR1H2_ENST00000542413.1_5'UTR|NR1H2_ENST00000598168.1_Missense_Mutation_p.E85G|NR1H2_ENST00000411902.2_Intron|NR1H2_ENST00000599105.1_Missense_Mutation_p.E85G	NM_007121.5	NP_009052.3	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	85					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CTGGGCCACGAGCTTTGCCGT	0.622000													73	194					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745550	77745550	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:77745550T>A	ENST00000409088.3	-	3	1859	c.1445A>T	c.(1444-1446)cAg>cTg	p.Q482L	LRRTM4_ENST00000409884.1_Missense_Mutation_p.Q482L|LRRTM4_ENST00000409911.1_Missense_Mutation_p.Q483L|LRRTM4_ENST00000409282.1_Missense_Mutation_p.Q483L|LRRTM4_ENST00000409093.1_Missense_Mutation_p.Q482L	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	482						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		ATAATACTCCTGTAAAGGGGA	0.478000													18	30					0	0	1	0	0
REEP2	51308	broad.mit.edu	37	5	137781192	137781192	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:137781192A>G	ENST00000378339.2	+	7	793	c.601A>G	c.(601-603)Aac>Gac	p.N201D	REEP2_ENST00000254901.5_Missense_Mutation_p.N199D|REEP2_ENST00000506158.1_Missense_Mutation_p.N161D	NM_001271803.1	NP_001258732.1	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	199						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GTCCAGCACAAACCCGGCAGA	0.577000													21	45					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46125926	46125926	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:46125926C>A	ENST00000295452.4	-	1	172	c.5G>T	c.(4-6)gGt>gTt	p.G2V		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	2					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTTCAAAGGACCCATCGGAAT	0.507000													10	36					3.86212e-05	4.12793e-05	1	1	0
MUC21	394263	broad.mit.edu	37	6	30954218	30954218	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:30954218C>G	ENST00000376296.3	+	2	507	c.266C>G	c.(265-267)aCa>aGa	p.T89R	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	89	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						GGGATCAGCACAGCCACCAAC	0.577000													66	175					0	0	1	0	0
TACR1	6869	broad.mit.edu	37	2	75276738	75276738	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:75276738A>C	ENST00000305249.4	-	5	1810	c.1045T>G	c.(1045-1047)Tac>Gac	p.Y349D		NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1	349					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	CTGACTTTGTACACACTGCCC	0.632000													27	52					0	0	1	0	0
UBE3A	7337	broad.mit.edu	37	15	25650642	25650642	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:25650642C>A	ENST00000232165.3	-	4	684	c.28G>T	c.(28-30)Gaa>Taa	p.E10*	SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000397954.2_Nonsense_Mutation_p.E13*|UBE3A_ENST00000438097.1_5'UTR|UBE3A_ENST00000428984.2_5'UTR|UBE3A_ENST00000566215.1_5'UTR	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	13					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GACTGAGGTTCTCCTGATCTG	0.348000													47	79					5.34276e-22	7.66569e-22	1	1	0
IVNS1ABP	10625	broad.mit.edu	37	1	185278522	185278522	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:185278522C>A	ENST00000367498.3	-	3	726	c.104G>T	c.(103-105)cGa>cTa	p.R35L	IVNS1ABP_ENST00000459929.1_5'UTR|IVNS1ABP_ENST00000392007.3_5'UTR|IVNS1ABP_ENST00000367497.1_Missense_Mutation_p.R35L	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	35	BTB.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						TACCTGAAGTCGAACATCACA	0.294000													23	46					7.88262e-20	1.09527e-19	1	1	0
CYTH4	27128	broad.mit.edu	37	22	37692052	37692052	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:37692052G>A	ENST00000248901.6	+	4	367	c.180G>A	c.(178-180)caG>caA	p.Q60Q	CYTH4_ENST00000405206.3_Silent_p.Q60Q|CYTH4_ENST00000439667.1_3'UTR|CYTH4_ENST00000402997.1_Silent_p.Q60Q	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	60	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						GGATGGCCCAGAAGGAGAAGG	0.632000													7	24					0	0	1	0	0
CXorf67	340602	broad.mit.edu	37	X	51150091	51150091	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:51150091G>A	ENST00000342995.2	+	1	325	c.223G>A	c.(223-225)Gcc>Acc	p.A75T						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						CGCCACCTCCGCCGCCATTTT	0.647000													14	22					0	0	1	0	0
PEG10	23089	broad.mit.edu	37	7	94293017	94293017	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:94293017C>A	ENST00000482108.1	+	2	628	c.149C>A	c.(148-150)cCc>cAc	p.P50H	PEG10_ENST00000488574.1_Missense_Mutation_p.P50H	NM_001040152.1|NM_001172438.1|NM_001184962.1	NP_001035242.1|NP_001165909.1|NP_001171891.1	Q86TG7	PEG10_HUMAN	paternally expressed 10	50					apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(9)|prostate(3)|skin(1)	21	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAGTGGAACCCACCCCTGAG	0.582000													12	14					6.40141e-05	6.80069e-05	1	1	0
IMPG2	50939	broad.mit.edu	37	3	100992575	100992575	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:100992575T>A	ENST00000193391.7	-	7	865	c.678A>T	c.(676-678)gaA>gaT	p.E226D		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	226					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CATTCTCAATTTCATTGCTAA	0.358000													27	62					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39869801	39869801	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:39869801G>T	ENST00000538976.1	+	25	3374	c.3192G>T	c.(3190-3192)cgG>cgT	p.R1064R	DAAM2_ENST00000274867.4_Silent_p.R1065R|DAAM2_ENST00000398904.2_Silent_p.R1065R	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	1065					actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					CAATAAACCGGCTAAATTATT	0.562000													6	29					0.248553	0.25045	1	1	0
LILRA2	11027	broad.mit.edu	37	19	55098738	55098738	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:55098738C>A	ENST00000251377.3	+	9	1510	c.1377C>A	c.(1375-1377)gtC>gtA	p.V459V	LILRA2_ENST00000391738.3_Silent_p.V459V|LILRA2_ENST00000251376.3_Silent_p.V442V|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000391737.1_Silent_p.V430V					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CTGGCTTGGTCCTGGTGGTCC	0.562000													28	55					4.22769e-11	5.11978e-11	1	1	0
PRKCQ	5588	broad.mit.edu	37	10	6539186	6539186	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:6539186G>T	ENST00000263125.5	-	6	669	c.570C>A	c.(568-570)tgC>tgA	p.C190*	PRKCQ_ENST00000539722.1_Nonsense_Mutation_p.C65*|PRKCQ_ENST00000397176.2_Nonsense_Mutation_p.C190*	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	190					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						ACTTACGTCGGCACTGGTAGC	0.378000													92	102					1.28662e-36	2.01583e-36	1	1	0
IQCG	84223	broad.mit.edu	37	3	197670845	197670845	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:197670845G>A	ENST00000265239.6	-	4	510	c.86C>T	c.(85-87)cCt>cTt	p.P29L	IQCG_ENST00000455191.1_Missense_Mutation_p.P29L|IQCG_ENST00000453254.1_Missense_Mutation_p.P29L|IQCG_ENST00000480302.1_5'UTR	NM_032263.3	NP_115639.1	Q9H095	IQCG_HUMAN	IQ motif containing G	29										autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TACGGTACTAGGTGGTTCGCC	0.443000													54	147					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830263	13830263	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:13830263C>A	ENST00000265104.4	-	37	6225	c.6121G>T	c.(6121-6123)Gtt>Ttt	p.V2041F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2041	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ACCGAGAGAACTGGTAGATCA	0.358000									Kartagener syndrome				21	46					1.00905e-13	1.28071e-13	1	1	0
TMEM171	134285	broad.mit.edu	37	5	72419619	72419619	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:72419619G>A	ENST00000454765.2	+	2	892	c.419G>A	c.(418-420)tGg>tAg	p.W140*	TMEM171_ENST00000287773.5_Nonsense_Mutation_p.W140*			Q8WVE6	TM171_HUMAN	transmembrane protein 171	140						integral to membrane				endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		GGCTCCAACTGGGCGCAGGAA	0.567000													50	79					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32017975	32017975	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:32017975C>A	ENST00000375244.3	-	27	9440	c.9239G>T	c.(9238-9240)tGg>tTg	p.W3080L	TNXB_ENST00000375247.2_Missense_Mutation_p.W3078L			P22105	TENX_HUMAN	tenascin XB	3125					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GGGAACCATCCAGGACAGGCT	0.667000													38	78					1.03484e-13	1.3103e-13	1	1	0
PRICKLE3	4007	broad.mit.edu	37	X	49040166	49040166	+	Silent	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:49040166G>C	ENST00000536904.1	-	3	358	c.129C>G	c.(127-129)tcC>tcG	p.S43S	PRICKLE3_ENST00000538114.1_Silent_p.S111S|PRICKLE3_ENST00000376310.3_Intron|PRICKLE3_ENST00000376317.3_Intron|PRICKLE3_ENST00000540849.1_Intron			O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	111							protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						CAGCAAGAGTGGAGGGCTGGC	0.602000													8	32					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1720350	1720350	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:1720350A>T	ENST00000313871.3	+	5	2147	c.1951A>T	c.(1951-1953)Agc>Tgc	p.S651C		NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	651	Arg-rich.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						GAGGTCCCACAGCAAAGACAG	0.736000													4	17					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45878011	45878011	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:45878011G>A	ENST00000374391.2	+	2	284	c.231G>A	c.(229-231)ctG>ctA	p.L77L	ALOX5_ENST00000542434.1_Silent_p.L77L	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	77	PLAT.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding	p.L77L(1)		breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	AGTACTGGCTGAATGACGACT	0.567000													26	46					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100339997	100339997	+	RNA	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:100339997G>C	ENST00000341853.1	-	0	929					NR_003260.1																						GTGTCTTCTCGTTCCCACGCG	0.612000													5	51					0	0	1	0	0
RAB6B	51560	broad.mit.edu	37	3	133560157	133560157	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:133560157C>A	ENST00000285208.4	-	4	610	c.261G>T	c.(259-261)acG>acT	p.T87T	RAB6B_ENST00000486858.1_Silent_p.T74T|RAB6B_ENST00000469959.1_Intron|RAB6B_ENST00000543906.1_Silent_p.T87T	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	87					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						CCACAGCCACCGTGGAGTCCC	0.637000													67	75					6.07461e-23	8.76337e-23	1	1	0
OR5D18	219438	broad.mit.edu	37	11	55587658	55587658	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:55587658C>T	ENST00000333976.4	+	1	573	c.553C>T	c.(553-555)Cta>Tta	p.L185L		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				GTTCTCCTCACTACTCTCCCT	0.423000													98	46					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176295145	176295145	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:176295145G>T	ENST00000329542.4	+	3	581	c.307G>T	c.(307-309)Gag>Tag	p.E103*	UNC5A_ENST00000261961.3_Nonsense_Mutation_p.E63*	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	103	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCCACCATGGAGGTCCGCAT	0.642000													35	79					2.75727e-19	3.7814e-19	1	1	0
ARHGAP4	393	broad.mit.edu	37	X	153178914	153178914	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:153178914C>A	ENST00000370028.3	-	10	1452	c.1395G>T	c.(1393-1395)caG>caT	p.Q465H	ARHGAP4_ENST00000393721.1_Missense_Mutation_p.Q247H|ARHGAP4_ENST00000350060.5_Missense_Mutation_p.Q425H|ARHGAP4_ENST00000537206.1_Missense_Mutation_p.Q402H|ARHGAP4_ENST00000370016.1_Missense_Mutation_p.Q404H	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	425					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCGGCCCGCCTGCCGGCTGC	0.692000													42	63					2.0833e-19	2.86454e-19	1	1	0
GIMAP8	155038	broad.mit.edu	37	7	150163813	150163813	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:150163813C>T	ENST00000307271.3	+	2	601	c.27C>T	c.(25-27)tcC>tcT	p.S9S		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	9						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GCCAGATGTCCGAACTGCGGC	0.507000													21	42					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169299609	169299609	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:169299609G>A	ENST00000511577.1	-	33	4628	c.4381C>T	c.(4381-4383)Caa>Taa	p.Q1461*	DDX60L_ENST00000260184.7_Nonsense_Mutation_p.Q1461*			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1461							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ATCACATCTTGGGAAAATTGT	0.279000													3	6					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50367257	50367257	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:50367257G>T	ENST00000331340.3	+	3	219	c.64G>T	c.(64-66)Gat>Tat	p.D22Y	IKZF1_ENST00000439701.1_Missense_Mutation_p.D22Y|IKZF1_ENST00000349824.4_Missense_Mutation_p.D22Y|IKZF1_ENST00000440768.2_Missense_Mutation_p.D22Y|IKZF1_ENST00000359197.5_Missense_Mutation_p.D22Y|IKZF1_ENST00000343574.5_Missense_Mutation_p.D22Y|IKZF1_ENST00000438033.1_Missense_Mutation_p.D22Y|IKZF1_ENST00000413698.1_Missense_Mutation_p.D22Y|IKZF1_ENST00000346667.4_Missense_Mutation_p.D22Y|IKZF1_ENST00000357364.4_Missense_Mutation_p.D22Y|IKZF1_ENST00000492782.1_3'UTR	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	22					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(33)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CCCTGTAAGCGATACTCCAGA	0.587000			"""D,T"""	BCL6	"""ALL, DLBCL"""								72	10					8.83742e-36	1.36837e-35	1	1	0
CD163L1	283316	broad.mit.edu	37	12	7586251	7586251	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:7586251C>T	ENST00000313599.3	-	3	221	c.164G>A	c.(163-165)gGt>gAt	p.G55D	CD163L1_ENST00000416109.2_Missense_Mutation_p.G55D|CD163L1_ENST00000396630.1_Missense_Mutation_p.G55D			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	55	SRCR 1.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						AGAGCAGGGACCGTCTCCATT	0.473000													46	76					0	0	1	0	0
MS4A1	931	broad.mit.edu	37	11	60233490	60233490	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:60233490C>A	ENST00000534668.1	+	5	722	c.433C>A	c.(433-435)Cat>Aat	p.H145N	MS4A1_ENST00000389939.2_Missense_Mutation_p.H145N|MS4A1_ENST00000532073.1_Missense_Mutation_p.H145N|MS4A1_ENST00000345732.4_Missense_Mutation_p.H145N|MS4A1_ENST00000528313.1_Intron	NM_152866.2	NP_690605.1	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member 1	145					B cell activation|immune response	integral to plasma membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	TAAAATTTCCCATTTTTTAAA	0.333000													36	14					4.65686e-17	6.16247e-17	1	1	0
PHKA2	5256	broad.mit.edu	37	X	18956846	18956846	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:18956846C>A	ENST00000379942.4	-	10	1605	c.940G>T	c.(940-942)Gac>Tac	p.D314Y		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	314					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					TCAGCAGGGTCATAATGCAGT	0.393000													16	54					6.31663e-08	7.17243e-08	1	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90503164	90503164	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:90503164G>A	ENST00000325643.5	+	4	3828	c.3762G>A	c.(3760-3762)aaG>aaA	p.K1254K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		AGCTGGAGAAGGGACAGACAC	0.552000													29	25					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540265	94540265	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:94540265A>G	ENST00000289495.5	+	1	1056	c.840A>G	c.(838-840)ccA>ccG	p.P280P	PPP1R9A_ENST00000340694.4_Silent_p.P280P|PPP1R9A_ENST00000424654.1_Silent_p.P280P|PPP1R9A_ENST00000433881.1_Silent_p.P280P|PPP1R9A_ENST00000433360.1_Silent_p.P280P|PPP1R9A_ENST00000456331.2_Silent_p.P280P	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	280						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CTCCAGTACCAGAAGTGGCTT	0.478000										HNSCC(28;0.073)			23	43					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947505	57947505	+	Missense_Mutation	SNP	G	G	C	rs138122197	byFrequency	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:57947505G>C	ENST00000335397.3	+	3	905	c.589G>C	c.(589-591)Gtg>Ctg	p.V197L		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				CACTCAAGAAGTGCTGATTAT	0.468000													67	35					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374293	95374293	+	RNA	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:95374293G>T	ENST00000494840.1	-	0	1568					NR_077228.1																						CCTAGGGTTGGAATGTCAGTT	0.458000													22	53					6.44725e-10	7.61555e-10	1	1	0
RNF19A	25897	broad.mit.edu	37	8	101276908	101276908	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:101276908C>T	ENST00000519449.1	-	7	1613	c.1297G>A	c.(1297-1299)Gtg>Atg	p.V433M	RNF19A_ENST00000341084.2_Missense_Mutation_p.V433M|RNF19A_ENST00000523255.1_5'UTR	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	433					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CCTACAGTCACTGCAGCTACT	0.363000													28	86					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80782995	80782995	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:80782995C>G	ENST00000466387.1	+	16	2442	c.1718C>G	c.(1717-1719)gCt>gGt	p.A573G	CTNNA2_ENST00000361291.4_Missense_Mutation_p.A607G|CTNNA2_ENST00000496558.1_Missense_Mutation_p.A573G|CTNNA2_ENST00000402739.4_Missense_Mutation_p.A573G|CTNNA2_ENST00000541047.1_Missense_Mutation_p.A573G|CTNNA2_ENST00000540488.1_Missense_Mutation_p.A573G|CTNNA2_ENST00000343114.3_Missense_Mutation_p.A252G			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	573					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GTGTTGGAAGCTACAAAATTG	0.438000													32	79					0	0	1	0	0
LYRM9	201229	broad.mit.edu	37	17	26209688	26209688	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:26209688C>A	ENST00000460380.2	-	2	93	c.33G>T	c.(31-33)cgG>cgT	p.R11R	LYRM9_ENST00000379102.3_Silent_p.R11R|LYRM9_ENST00000379103.3_Silent_p.R11R|RP1-66C13.4_ENST00000582441.1_Silent_p.R11R|LYRM9_ENST00000508862.1_Silent_p.R11R|LYRM9_ENST00000503642.1_Silent_p.R11R					LYR motif containing 9																		GCAGTGGCCTCCGAACCAGTT	0.587000													8	7					1.06961e-07	1.20674e-07	1	1	0
CEP170	9859	broad.mit.edu	37	1	243354691	243354691	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:243354691T>A	ENST00000366542.1	-	8	788	c.737A>T	c.(736-738)aAa>aTa	p.K246I	CEP170_ENST00000366544.1_Missense_Mutation_p.K246I|CEP170_ENST00000366543.1_Missense_Mutation_p.K246I	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	246						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CTGGAATTCTTTTGTAGGGAT	0.408000													4	14					0	0	1	0	0
CYB561	1534	broad.mit.edu	37	17	61512558	61512558	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:61512558G>A	ENST00000584031.1	-	5	798	c.499C>T	c.(499-501)Ccc>Tcc	p.P167S	CYB561_ENST00000582034.1_Missense_Mutation_p.S122F|CYB561_ENST00000581163.1_5'UTR|CYB561_ENST00000582297.1_Missense_Mutation_p.S151F|CYB561_ENST00000581573.1_Missense_Mutation_p.S151F|CYB561_ENST00000542042.1_Missense_Mutation_p.S218F|CYB561_ENST00000448884.2_Intron|CYB561_ENST00000582997.1_Missense_Mutation_p.S158F|CYB561_ENST00000392975.2_Missense_Mutation_p.S151F|CYB561_ENST00000392976.1_Missense_Mutation_p.S151F|CYB561_ENST00000360793.3_Missense_Mutation_p.S151F			P49447	CY561_HUMAN	cytochrome b561	0	Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			lung(2)|ovary(1)|prostate(1)	4				READ - Rectum adenocarcinoma(1115;0.0689)		GCTCCGCAGGGAGAATGAAGC	0.627000													28	112					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48936911	48936911	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:48936911G>A	ENST00000316623.5	-	2	511	c.56C>T	c.(55-57)tCc>tTc	p.S19F	FBN1_ENST00000560355.1_Missense_Mutation_p.S19F	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	19					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCTCGTGTAGGACGCTAAAAG	0.662000													67	30					0	0	1	0	0
FTH1P3	2498	broad.mit.edu	37	5	17354524	17354524	+	RNA	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:17354524G>A	ENST00000511821.1	+	0	383				FTH1P10_ENST00000401830.3_RNA																							AGGTGGACGCGGTCGTCATGG	0.677000													13	24					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630099	9630099	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:9630099G>A	ENST00000382492.2	-	1	364	c.46C>T	c.(46-48)Caa>Taa	p.Q16*	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	16					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						AGAAGAAATTGTATCACTGCA	0.338000													17	48					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868761	97868761	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:97868761T>G	ENST00000437310.1	+	1	592	c.532T>G	c.(532-534)Tac>Gac	p.Y178D		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ACAACACTTTTACTGTGACAT	0.299000													88	85					0	0	1	0	0
MIR4485	100616263	broad.mit.edu	37	MT	2064	2064	+	RNA	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrM:2064A>G	ENST00000387347.2	+	0	394					NR_039705.1																						ATTTGCCCACAGAACCCTCTA	0.388000													20	13					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80771803	80771803	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:80771803T>G	ENST00000458043.2	+	58	7016	c.7010T>G	c.(7009-7011)aTa>aGa	p.I2337R	OTOGL_ENST00000547103.1_Missense_Mutation_p.I2325R|OTOGL_ENST00000546620.1_Missense_Mutation_p.I356R	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CAGGAACCCATAGACTGTACG	0.408000													6	7					0	0	1	0	0
PRKRA	8575	broad.mit.edu	37	2	179315021	179315021	+	Silent	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:179315021T>A	ENST00000325748.4	-	2	383	c.183A>T	c.(181-183)atA>atT	p.I61I	PRKRA_ENST00000470200.1_5'UTR|PRKRA_ENST00000438687.3_5'UTR|PRKRA_ENST00000487082.1_Silent_p.I36I|PRKRA_ENST00000432031.2_Silent_p.I50I	NM_003690.4	NP_003681.1	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double stranded RNA dependent activator	61	DRBM 1.|Sufficient for self-association and interaction with TARBP2.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(2)	19			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			TGGGCACGTGTATTTGCACAT	0.458000													84	187					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162903977	162903977	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:162903977G>A	ENST00000360534.3	-	3	689	c.129C>T	c.(127-129)taC>taT	p.Y43Y		NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	43					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	CAGTTAGAGTGTAAGTTTTGC	0.338000													19	30					0	0	1	0	0
ZNF419	79744	broad.mit.edu	37	19	58004986	58004986	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:58004986A>G	ENST00000424930.2	+	5	1293	c.1064A>G	c.(1063-1065)cAc>cGc	p.H355R	ZNF419_ENST00000426954.2_Missense_Mutation_p.H342R|ZNF419_ENST00000415379.2_Missense_Mutation_p.H308R|ZNF419_ENST00000354197.4_Missense_Mutation_p.H342R|AC003005.4_ENST00000601674.1_Intron|ZNF419_ENST00000442920.2_Missense_Mutation_p.H341R|ZNF419_ENST00000221735.7_Missense_Mutation_p.H354R|ZNF419_ENST00000347466.6_Missense_Mutation_p.H322R	NM_001098491.1|NM_024691.3	NP_001091961.1|NP_078967.3	Q96HQ0	ZN419_HUMAN	zinc finger protein 419	354					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		TTCTATAGCCACAAGTCCAAC	0.413000													39	77					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7527898	7527898	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:7527898C>A	ENST00000303635.7	+	6	654	c.447C>A	c.(445-447)taC>taA	p.Y149*	CAMTA1_ENST00000439411.2_Nonsense_Mutation_p.Y149*	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGTGCTTGTACGGCTGCTATG	0.542000			T	WWTR1	epitheliod hemangioendothelioma								45	106					1.81118e-26	2.70142e-26	1	1	0
CEACAM20	125931	broad.mit.edu	37	19	45015211	45015211	+	RNA	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:45015211C>T	ENST00000454753.1	-	0	1893							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				AAGGCAGCTTCGTCTGCAAGT	0.532000													29	38					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212570	26212570	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:26212570G>A	ENST00000379034.1	+	2	756	c.607G>A	c.(607-609)Gcg>Acg	p.A203T		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	203	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						GTGCACGTTGGCGCAATTCCT	0.473000													39	49					0	0	1	0	0
GEMIN4	50628	broad.mit.edu	37	17	650823	650823	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:650823C>A	ENST00000576778.1	-	1	1768	c.427G>T	c.(427-429)Gcc>Tcc	p.A143S	GEMIN4_ENST00000319004.5_Missense_Mutation_p.A154S|GEMIN4_ENST00000437269.1_Missense_Mutation_p.A154S			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	154					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		ACGTCTTCGGCAGAAGTGTCA	0.572000													53	49					2.29192e-23	3.3337e-23	1	1	0
MAGEC1	9947	broad.mit.edu	37	X	140993651	140993651	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:140993651C>A	ENST00000285879.4	+	4	747	c.461C>A	c.(460-462)cCt>cAt	p.P154H	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	154							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					ACTCAAAGTCCTTTTGAGGGT	0.493000										HNSCC(15;0.026)			58	88					1.48341e-19	2.05037e-19	1	1	0
FLNA	2316	broad.mit.edu	37	X	153581217	153581217	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:153581217G>A	ENST00000422373.1	-	38	6526	c.6278C>T	c.(6277-6279)aCg>aTg	p.T2093M	FLNA_ENST00000360319.4_Missense_Mutation_p.T2093M|FLNA_ENST00000369850.3_Missense_Mutation_p.T2101M|FLNA_ENST00000344736.4_Missense_Mutation_p.T2061M|FLNA_ENST00000369856.3_Missense_Mutation_p.T234M	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2101					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GACCCTGCACGTCCCGTCCTC	0.602000													41	74					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38939426	38939426	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:38939426G>T	ENST00000359357.3	+	81	12113	c.11859G>T	c.(11857-11859)caG>caT	p.Q3953H	DNAH8_ENST00000441566.1_Missense_Mutation_p.Q3917H|DNAH8_ENST00000449981.2_Missense_Mutation_p.Q4170H					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGCTGATTCAGATGTCAATGC	0.423000													18	41					1.00905e-13	1.28071e-13	1	1	0
KLK15	55554	broad.mit.edu	37	19	51329147	51329147	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:51329147C>A	ENST00000326856.4	-	6	802	c.673G>T	c.(673-675)Ggt>Tgt	p.G225C	KLK15_ENST00000598239.1_Missense_Mutation_p.G226C|KLK15_ENST00000416184.1_Missense_Mutation_p.G141C|KLK15_ENST00000301421.2_3'UTR|KLK15_ENST00000596931.1_3'UTR	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	226	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GGGACGTCACCCCAGGACACA	0.557000													10	51					0.000442599	0.000463676	1	1	0
ZNF630	57232	broad.mit.edu	37	X	47918112	47918112	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:47918112A>G	ENST00000276054.4	-	5	2281	c.1347T>C	c.(1345-1347)tgT>tgC	p.C449C	ZNF630_ENST00000409324.3_Silent_p.C573C|ZNF630-AS1_ENST00000436124.1_RNA|ZNF630_ENST00000442455.3_Silent_p.C559C			Q2M218	ZN630_HUMAN	zinc finger protein 630	573					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						CACATTCACTACATTCATAGG	0.448000													9	35					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74638523	74638523	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:74638523G>A	ENST00000287936.4	+	2	249	c.93G>A	c.(91-93)atG>atA	p.M31I	HMGCR_ENST00000343975.5_Missense_Mutation_p.M31I|HMGCR_ENST00000511206.1_Missense_Mutation_p.M31I	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	31					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CCATCTGCATGATGTCCATGA	0.413000													19	48					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5654186	5654186	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:5654186A>G	ENST00000292123.5	+	12	1748	c.1641A>G	c.(1639-1641)tcA>tcG	p.S547S	SAFB_ENST00000538656.1_Silent_p.S390S|SAFB_ENST00000454510.1_Silent_p.S478S|SAFB_ENST00000433404.1_Silent_p.S377S|SAFB_ENST00000592224.1_Silent_p.S547S|SAFB_ENST00000588852.1_Silent_p.S547S	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	547	Interaction with POLR2A.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		CTGGCCCCTCAGAGCGATCTC	0.478000													24	25					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126261419	126261419	+	Nonstop_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:126261419T>A	ENST00000319340.2	+	3	1074	c.1024T>A	c.(1024-1026)Tag>Aag	p.*342K		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	0					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		GCGGCTGCTCTAGCGGTCCTG	0.642000													4	29					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128490862	128490862	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:128490862G>T	ENST00000325888.8	+	33	5665	c.5404G>T	c.(5404-5406)Gtg>Ttg	p.V1802L	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.V1769L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1802					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TGCAGGAGAGGTGCGGATGCC	0.627000													37	51					1.30015e-28	1.97264e-28	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176734869	176734869	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:176734869G>C	ENST00000367662.3	+	15	5383	c.4219G>C	c.(4219-4221)Gtg>Ctg	p.V1407L		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1407	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGCTGATGTGGTGAACTGTAC	0.512000													43	87					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004760	74004760	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:74004760A>T	ENST00000301607.3	-	22	4779	c.4526T>A	c.(4525-4527)cTc>cAc	p.L1509H	EVPL_ENST00000586740.1_Missense_Mutation_p.L1531H	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1509	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GGCTTTCTGGAGGACGTCAAT	0.592000													39	166					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10629271	10629271	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:10629271C>A	ENST00000254958.5	-	12	2010	c.1495G>T	c.(1495-1497)Ggg>Tgg	p.G499W	JAG1_ENST00000423891.2_Missense_Mutation_p.G340W	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	499	EGF-like 8; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						CAGTGACCCCCATTCAAACAG	0.493000									Alagille Syndrome				26	42					3.65163e-15	4.74892e-15	1	1	0
CD163L1	283316	broad.mit.edu	37	12	7585151	7585151	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:7585151A>G	ENST00000313599.3	-	4	684	c.627T>C	c.(625-627)aaT>aaC	p.N209N	CD163L1_ENST00000416109.2_Silent_p.N219N|CD163L1_ENST00000396630.1_Silent_p.N209N			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	209	SRCR 2.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CAGCAGGGCTATTAACAACTC	0.473000													23	44					0	0	1	0	0
EFHC2	80258	broad.mit.edu	37	X	44088978	44088978	+	Silent	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:44088978T>C	ENST00000420999.1	-	11	1751	c.1668A>G	c.(1666-1668)gaA>gaG	p.E556E		NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	556							calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						ATTTTCCTTCTTCTTGCTTCA	0.373000													21	59					0	0	1	0	0
ZNF587B	100293516	broad.mit.edu	37	19	58353072	58353072	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:58353072C>A	ENST00000442832.4	+	3	1264	c.1030C>A	c.(1030-1032)Cat>Aat	p.H344N	ZNF587B_ENST00000316462.4_Intron|ZNF587B_ENST00000594901.1_Missense_Mutation_p.H344N|CTD-2583A14.10_ENST00000598031.1_Intron	NM_001204818.1	NP_001191747.1	B4DR41	B4DR41_HUMAN	zinc finger protein 587B	344					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding										CCTTAAGAGTCATCAGCGCAT	0.448000													9	12					0.00621372	0.00644566	1	1	0
ZNF587B	100293516	broad.mit.edu	37	19	58353079	58353079	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:58353079G>T	ENST00000442832.4	+	3	1271	c.1037G>T	c.(1036-1038)cGc>cTc	p.R346L	ZNF587B_ENST00000316462.4_Intron|ZNF587B_ENST00000594901.1_Missense_Mutation_p.R346L|CTD-2583A14.10_ENST00000598031.1_Intron	NM_001204818.1	NP_001191747.1	B4DR41	B4DR41_HUMAN	zinc finger protein 587B	346					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding										AGTCATCAGCGCATTCACACT	0.448000													6	18					3.59834e-05	3.8538e-05	1	1	0
FAM122A	116224	broad.mit.edu	37	9	71395383	71395383	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:71395383G>A	ENST00000394264.3	+	1	420	c.303G>A	c.(301-303)acG>acA	p.T101T	PIP5K1B_ENST00000265382.3_Intron|PIP5K1B_ENST00000541509.1_Intron	NM_138333.3	NP_612206.3	Q96E09	F122A_HUMAN	family with sequence similarity 122A	101										endometrium(1)|lung(2)	3						ACCGAGAGACGGTCCACGAAC	0.602000													61	59					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247597412	247597412	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:247597412C>G	ENST00000366497.2	+	6	3115	c.2335C>G	c.(2335-2337)Cgc>Ggc	p.R779G	NLRP3_ENST00000391827.2_Missense_Mutation_p.R722G|NLRP3_ENST00000366496.2_Missense_Mutation_p.R779G|NLRP3_ENST00000336119.3_Missense_Mutation_p.R779G|NLRP3_ENST00000391828.3_Missense_Mutation_p.R779G|NLRP3_ENST00000348069.2_Missense_Mutation_p.R722G	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	836					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AAGGTTGGGGCGCTGTGGCCT	0.562000													67	93					0	0	1	0	0
G6PC3	92579	broad.mit.edu	37	17	42153198	42153198	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:42153198A>G	ENST00000269097.4	+	6	1059	c.828A>G	c.(826-828)gcA>gcG	p.A276A		NM_138387.3	NP_612396.1	Q9BUM1	G6PC3_HUMAN	glucose 6 phosphatase, catalytic, 3	276					gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	11		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TGCGTCGGGCACAGCTGGGAA	0.662000													6	69					0	0	1	0	0
DUSP13	51207	broad.mit.edu	37	10	76854571	76854571	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:76854571T>C	ENST00000491677.2	-	8	1389	c.847A>G	c.(847-849)Atg>Gtg	p.M283V	DUSP13_ENST00000605915.1_Missense_Mutation_p.M176V|DUSP13_ENST00000607131.1_Missense_Mutation_p.M247V|DUSP13_ENST00000464872.1_Missense_Mutation_p.M103V|DUSP13_ENST00000472493.2_Missense_Mutation_p.M154V|DUSP13_ENST00000372702.3_3'UTR|DUSP13_ENST00000372700.3_Missense_Mutation_p.M204V|DUSP13_ENST00000478873.2_Missense_Mutation_p.M290V	NM_001007271.1	NP_001007272.1	Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13	145						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TCACAGATCATGAGGAAGGCC	0.587000													17	33					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177261	89177261	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:89177261C>A	ENST00000561129.2	+	1	307	c.177C>A	c.(175-177)gcC>gcA	p.A59A	TGIF2LX_ENST00000283891.5_Silent_p.A59A			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	59						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						ACTTGCCAGCCGAGTCCGTTA	0.483000													21	45					2.81731e-10	3.35032e-10	1	1	0
APOB	338	broad.mit.edu	37	2	21242604	21242604	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:21242604C>G	ENST00000233242.1	-	19	3117	c.2990G>C	c.(2989-2991)gGg>gCg	p.G997A		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	997					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCTGGTGTCCCCGGTCAGCGG	0.527000													15	22					0	0	1	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214435	11214435	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:11214435T>C	ENST00000533467.1	-	1	458	c.459A>G	c.(457-459)atA>atG	p.I153M	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176887.2	NP_795368.2	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	153					sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		CTTTTGTCCATATAATCTGAT	0.358000													28	59					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:7578457C>A	ENST00000420246.2	-	5	605	c.473G>T	c.(472-474)cGc>cTc	p.R158L	TP53_ENST00000455263.2_Missense_Mutation_p.R158L|TP53_ENST00000445888.2_Missense_Mutation_p.R158L|TP53_ENST00000269305.4_Missense_Mutation_p.R158L|TP53_ENST00000413465.2_Missense_Mutation_p.R158L|TP53_ENST00000359597.4_Missense_Mutation_p.R158L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	158	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158L(77)|p.R158H(74)|p.R158P(9)|p.R65L(8)|p.0?(8)|p.R26L(8)|p.R158fs(6)|p.R158fs*11(6)|p.R65H(5)|p.R26H(5)|p.R158_A159insX(4)|p.R65fs(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R26fs(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R26fs*11(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R65fs*11(1)|p.R156fs*20(1)|p.R158C(1)|p.V157_I162delVRAMAI(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	30					3.66082e-28	5.50687e-28	1	1	0
ACE2	59272	broad.mit.edu	37	X	15593813	15593813	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:15593813C>A	ENST00000427411.1	-	11	1634	c.1418G>T	c.(1417-1419)tGg>tTg	p.W473L	ACE2_ENST00000252519.3_Missense_Mutation_p.W473L	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	473					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	CTTTTTCATCCACTGGTCTTT	0.393000													17	59					3.52763e-06	3.85629e-06	1	1	0
ATAD3B	83858	broad.mit.edu	37	1	1417974	1417974	+	Missense_Mutation	SNP	C	C	T	rs3979437		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:1417974C>T	ENST00000308647.7	+	7	846	c.730C>T	c.(730-732)Cgg>Tgg	p.R244W	ATAD3B_ENST00000378741.3_Missense_Mutation_p.R76W|ATAD3B_ENST00000378736.2_3'UTR	NM_031921.4	NP_114127.3	Q5T9A4	ATD3B_HUMAN	ATPase family, AAA domain containing 3B	244							ATP binding|nucleoside-triphosphatase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGTGACAGACCGGGACAAAGT	0.587000													30	118					0	0	1	0	0
TUBE1	51175	broad.mit.edu	37	6	112392689	112392689	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:112392689G>T	ENST00000368662.5	-	12	1432	c.1354C>A	c.(1354-1356)Cag>Aag	p.Q452K	TUBE1_ENST00000604814.1_5'UTR	NM_016262.4	NP_057346.1	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	452					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	12		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TCATATTCCTGTATGAGTGCT	0.383000													43	84					6.68952e-21	9.41885e-21	1	1	0
TAB3	257397	broad.mit.edu	37	X	30873140	30873140	+	Silent	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:30873140T>C	ENST00000378933.1	-	3	819	c.642A>G	c.(640-642)caA>caG	p.Q214Q	TAB3_ENST00000378932.2_Silent_p.Q214Q|TAB3_ENST00000378930.3_Silent_p.Q214Q|TAB3_ENST00000288422.2_Silent_p.Q214Q	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	214	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						GTGGAAGAATTTGTAAAGCTC	0.408000													11	39					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75688105	75688105	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:75688105C>T	ENST00000370855.5	-	14	1139	c.1026G>A	c.(1024-1026)atG>atA	p.M342I	SLC44A5_ENST00000370859.3_Missense_Mutation_p.M342I|SLC44A5_ENST00000535611.1_Missense_Mutation_p.M212I	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	342						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						GGAAGATCAGCATGAGGATGA	0.398000													15	39					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48789568	48789568	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:48789568C>A	ENST00000316623.5	-	19	2643	c.2188G>T	c.(2188-2190)Gat>Tat	p.D730Y		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	730	EGF-like 11; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATATCAGGATCTAGTGCACAT	0.308000													61	18					1.88225e-35	2.90593e-35	1	1	0
FZD6	8323	broad.mit.edu	37	8	104337544	104337544	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:104337544G>T	ENST00000358755.4	+	4	1527	c.1210G>T	c.(1210-1212)Ggc>Tgc	p.G404C	FZD6_ENST00000540287.1_Missense_Mutation_p.G99C|FZD6_ENST00000523739.1_Missense_Mutation_p.G372C|FZD6_ENST00000522566.1_Missense_Mutation_p.G404C	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	404					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ACAACATGATGGCCGGAACCA	0.408000													75	130					1.64915e-30	2.50937e-30	1	1	0
STARD13	90627	broad.mit.edu	37	13	33685003	33685003	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr13:33685003C>T	ENST00000336934.5	-	11	2765	c.2649G>A	c.(2647-2649)gtG>gtA	p.V883V	STARD13_ENST00000255486.4_Silent_p.V875V|STARD13_ENST00000399365.3_Silent_p.V765V	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	883					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TCTCAGCCTCCACATACGAGT	0.547000													26	29					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19056269	19056269	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:19056269A>G	ENST00000421369.3	+	10	1629	c.1071A>G	c.(1069-1071)acA>acG	p.T357T	TMC7_ENST00000304381.5_Silent_p.T467T|TMC7_ENST00000569532.1_Silent_p.T467T	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	467						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						CCAAGATCACATCCTGTGATG	0.572000													52	87					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182363456	182363456	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:182363456G>A	ENST00000397033.2	+	15	2077	c.1647G>A	c.(1645-1647)caG>caA	p.Q549Q		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	549					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAAGCATACAGGTGTCCAGCA	0.368000													28	45					0	0	1	0	0
TMEM199	147007	broad.mit.edu	37	17	26684727	26684727	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:26684727G>T	ENST00000292114.3	+	1	124	c.34G>T	c.(34-36)Gtg>Ttg	p.V12L	TMEM199_ENST00000581386.1_3'UTR|CTB-96E2.3_ENST00000591482.1_RNA|TMEM199_ENST00000509083.1_Missense_Mutation_p.V12L	NM_152464.1	NP_689677.1	Q8N511	TM199_HUMAN	transmembrane protein 199	12						integral to membrane				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CGAGCGATTGGTGCGTGCTTT	0.697000													52	70					2.48254e-18	3.38703e-18	1	1	0
OR1J4	26219	broad.mit.edu	37	9	125281774	125281774	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:125281774G>C	ENST00000340750.1	+	1	355	c.355G>C	c.(355-357)Gca>Cca	p.A119P		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						CACTTCAATGGCATACGATCG	0.433000													39	34					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124364348	124364348	+	Splice_Site	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:124364348G>A	ENST00000409039.3	+	49	8305	c.8280_splice	c.e49+1	p.Q2760_splice		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2760					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTCTGTTCCAGGTGGGGATGA	0.592000													53	151					0	0	1	0	0
ZXDB	158586	broad.mit.edu	37	X	57618883	57618883	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:57618883G>T	ENST00000374888.1	+	1	615	c.402G>T	c.(400-402)gcG>gcT	p.A134A		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						AGAGCGGCGCGAATCCCGCGG	0.791000													5	11					1.23904e-05	1.33786e-05	1	1	0
TRBC2	28638	broad.mit.edu	37	7	142499645	142499645	+	RNA	SNP	G	G	T	rs1126990		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:142499645G>T	ENST00000466254.1	+	0	405																											CTTCACCTCCGGTAAGTGAGT	0.507000													102	234					5.1993e-48	8.19471e-48	1	1	0
TTN	7273	broad.mit.edu	37	2	179402257	179402257	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:179402257G>T	ENST00000589042.1	-	355	99901	c.99677C>A	c.(99676-99678)cCt>cAt	p.P33226H	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P31585H|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P24161H|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P24353H|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P24286H|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000415561.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P30658H|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31585							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCATGGCAGGTACTGGACG	0.423000													21	40					5.26018e-13	6.55041e-13	1	1	0
FNDC4	64838	broad.mit.edu	37	2	27716862	27716862	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:27716862C>A	ENST00000264703.3	-	4	780	c.389G>T	c.(388-390)gGg>gTg	p.G130V		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	130	Fibronectin type-III.					integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					CACCCGGGGCCCTGGGGGACT	0.602000													29	69					3.80469e-20	5.31449e-20	1	1	0
GDPD3	79153	broad.mit.edu	37	16	30123701	30123701	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:30123701C>T	ENST00000406256.3	-	5	786	c.409G>A	c.(409-411)Gac>Aac	p.D137N		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	137	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						TGGAACAGGTCCTCCAGACGA	0.602000											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	72					0	0	1	0	0
METTL13	51603	broad.mit.edu	37	1	171755114	171755114	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:171755114G>T	ENST00000361735.3	+	3	1275	c.1009G>T	c.(1009-1011)Gcc>Tcc	p.A337S	METTL13_ENST00000458517.1_Missense_Mutation_p.A336S|METTL13_ENST00000362019.3_Missense_Mutation_p.A251S|METTL13_ENST00000367737.5_Missense_Mutation_p.A181S	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	337							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						GATTACAGTGGCCCTTCACCG	0.607000													8	17					1.06961e-07	1.20674e-07	1	1	0
IL13RA1	3597	broad.mit.edu	37	X	117880934	117880934	+	Silent	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:117880934T>A	ENST00000371666.3	+	3	313	c.246T>A	c.(244-246)acT>acA	p.T82T	IL13RA1_ENST00000371642.1_Silent_p.T82T	NM_001560.2	NP_001551.1	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1	82						interleukin-13 receptor complex	cytokine receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)	12						CTCCGGAAACTCGTCGTTCAA	0.408000													21	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179447180	179447180	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:179447180G>T	ENST00000589042.1	-	314	66227	c.66003C>A	c.(66001-66003)ccC>ccA	p.P22001P	TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000591111.1_Silent_p.P20360P|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.P12936P|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342175.6_Silent_p.P13128P|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.P13061P|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342992.6_Silent_p.P19433P|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20360	Ig-like 115.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGCCCAGTTGGGCCTGCTTG	0.463000													16	32					9.16793e-09	1.05923e-08	1	1	0
EYA1	2138	broad.mit.edu	37	8	72156891	72156891	+	Missense_Mutation	SNP	C	C	G	rs121909198		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:72156891C>G	ENST00000340726.3	-	12	1726	c.1087G>C	c.(1087-1089)Gaa>Caa	p.E363Q	EYA1_ENST00000388742.4_Missense_Mutation_p.E363Q|EYA1_ENST00000388741.2_Missense_Mutation_p.E329Q|EYA1_ENST00000419131.1_Intron|EYA1_ENST00000388740.3_Missense_Mutation_p.E330Q|EYA1_ENST00000303824.7_Missense_Mutation_p.E357Q|EYA1_ENST00000388743.2_Missense_Mutation_p.E362Q	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	363			E -> K (in anterior segment anomalies).|E -> V (in BOR1).		double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ATCATTTCTTCCATTCGCAGT	0.333000													4	20					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26502016	26502016	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:26502016G>T	ENST00000244513.6	+	2	344	c.278G>T	c.(277-279)gGg>gTg	p.G93V		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	93	Ig-like V-type 1.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						GAGTACCGCGGGCGGGCGACG	0.657000													16	23					1.3612e-06	1.50045e-06	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113312290	113312290	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:113312290G>T	ENST00000401783.2	-	2	962	c.626C>A	c.(625-627)gCg>gAg	p.A209E	SVEP1_ENST00000302728.8_Missense_Mutation_p.A209E|SVEP1_ENST00000374469.1_Missense_Mutation_p.A186E|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374461.1_Missense_Mutation_p.A186E	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	209	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TCGCAGTGACGCTGCAATTGG	0.453000													36	27					1.22384e-17	1.64006e-17	1	1	0
ZC3H6	376940	broad.mit.edu	37	2	113082627	113082627	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:113082627A>T	ENST00000409871.1	+	11	2340	c.1939A>T	c.(1939-1941)Agc>Tgc	p.S647C	ZC3H6_ENST00000343936.4_Missense_Mutation_p.S647C	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	647							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						TGATGGCAGCAGCACTAGGAC	0.512000													17	25					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617405	77617405	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:77617405G>T	ENST00000521891.2	+	2	1530	c.1082G>T	c.(1081-1083)cGc>cTc	p.R361L	ZFHX4_ENST00000455469.2_Missense_Mutation_p.R361L|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.R361L|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R361L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	361						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAACCTTCCGCGGTTTATGG	0.463000										HNSCC(33;0.089)			30	65					2.81731e-10	3.35032e-10	1	1	0
CDH15	1013	broad.mit.edu	37	16	89260249	89260249	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:89260249G>T	ENST00000289746.2	+	13	2144	c.2079G>T	c.(2077-2079)caG>caT	p.Q693H		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	693					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		ATGCCCCGCAGGGCCGCCTGC	0.682000													12	5					3.27435e-08	3.73403e-08	1	1	0
USP8	9101	broad.mit.edu	37	15	50773966	50773966	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:50773966G>C	ENST00000433963.1	+	12	2007	c.1507G>C	c.(1507-1509)Gcc>Ccc	p.A503P	USP8_ENST00000307179.4_Missense_Mutation_p.A503P|USP8_ENST00000396444.3_Missense_Mutation_p.A503P|USP8_ENST00000425032.3_Missense_Mutation_p.A426P	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	503					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		agaacaaaaagccaaaaagaa	0.358000													4	2					0	0	1	0	0
KLHL11	55175	broad.mit.edu	37	17	40010890	40010890	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:40010890T>A	ENST00000319121.3	-	2	1289	c.1229A>T	c.(1228-1230)tAt>tTt	p.Y410F		NM_018143.1	NP_060613.1	Q9NVR0	KLH11_HUMAN	kelch-like family member 11	410						extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				TCCAGCAACATACACGTAGGA	0.408000													57	152					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68624335	68624335	+	Silent	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:68624335G>C	ENST00000423218.2	-	14	1727	c.1632C>G	c.(1630-1632)tcC>tcG	p.S544S	ITGA11_ENST00000315757.7_Silent_p.S544S			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	544					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	AGGCAATGGAGGACCCAAATC	0.532000													7	15					0	0	1	0	0
SRPK2	6733	broad.mit.edu	37	7	104800965	104800965	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:104800965T>C	ENST00000357311.3	-	6	748	c.577A>G	c.(577-579)Atc>Gtc	p.I193V	SRPK2_ENST00000393651.3_Missense_Mutation_p.I204V|SRPK2_ENST00000489828.1_Missense_Mutation_p.I193V	NM_001278273.1|NM_182691.1	NP_001265202.1|NP_872633.1	P78362	SRPK2_HUMAN	SRSF protein kinase 2	193	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(11)|large_intestine(6)|lung(4)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	35						TGTCGAATGATACTCTTCACA	0.448000													28	53					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105923675	105923675	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:105923675C>G	ENST00000526793.1	-	3	1900	c.1741G>C	c.(1741-1743)Gaa>Caa	p.E581Q	KBTBD3_ENST00000531837.1_Missense_Mutation_p.E581Q|KBTBD3_ENST00000534815.1_Missense_Mutation_p.E502Q	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	577										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		GGTGAAACTTCTTCCCATTCA	0.378000													10	85					0	0	1	0	0
NKAIN2	154215	broad.mit.edu	37	6	125112511	125112511	+	Silent	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:125112511T>C	ENST00000368417.1	+	5	561	c.501T>C	c.(499-501)taT>taC	p.Y167Y	NKAIN2_ENST00000546092.1_Silent_p.Y100Y|NKAIN2_ENST00000545433.1_Silent_p.Y152Y	NM_001040214.1	NP_001035304.1	Q5VXU1	NKAI2_HUMAN	Na+/K+ transporting ATPase interacting 2	167						integral to membrane|plasma membrane				cervix(1)|endometrium(1)|large_intestine(3)|lung(12)|skin(2)	19				GBM - Glioblastoma multiforme(226;0.104)		ACGCCTGTTATGTTGTGAAAT	0.408000													18	49					0	0	1	0	0
HIST3H2BB	128312	broad.mit.edu	37	1	228645991	228645991	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:228645991G>A	ENST00000369160.2	+	1	184	c.161G>A	c.(160-162)gGc>gAc	p.G54D		NM_175055.2	NP_778225.1	Q8N257	H2B3B_HUMAN	histone cluster 3, H2bb	54					nucleosome assembly	nucleosome|nucleus	DNA binding	p.G54D(2)		skin(1)	1		Prostate(94;0.183)				CCCGACACCGGCATCTCGTCC	0.587000													4	174					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154414491	154414491	+	Silent	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:154414491C>G	ENST00000229768.5	+	4	1301	c.1251C>G	c.(1249-1251)gtC>gtG	p.V417V	OPRM1_ENST00000435918.2_Intron|OPRM1_ENST00000518759.1_Intron|OPRM1_ENST00000414028.2_Intron|OPRM1_ENST00000330432.7_Intron|OPRM1_ENST00000522555.1_Intron|OPRM1_ENST00000522236.1_Intron|OPRM1_ENST00000452687.2_Intron|OPRM1_ENST00000419506.2_Intron|OPRM1_ENST00000360422.4_Intron|OPRM1_ENST00000520708.1_Intron|OPRM1_ENST00000337049.4_Intron|OPRM1_ENST00000524163.1_Intron|OPRM1_ENST00000434900.2_Intron	NM_001008505.1	NP_001008505.2	P35372	OPRM_HUMAN	opioid receptor, mu 1	0					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GACCTCTTGTCAGATATGACC	0.512000													68	156					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888675	38888675	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:38888675A>T	ENST00000450244.1	-	26	5084	c.4886T>A	c.(4885-4887)gTg>gAg	p.V1629E	SCN11A_ENST00000456224.3_Missense_Mutation_p.V1591E|SCN11A_ENST00000302328.3_Missense_Mutation_p.V1629E			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1629					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTTTCCCACACTTCATAAAA	0.418000													40	34					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146605	70146605	+	Silent	SNP	T	T	C	rs147283424		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:70146605T>C	ENST00000335568.5	+	1	389	c.387T>C	c.(385-387)gaT>gaC	p.D129D	UGT2B28_ENST00000511240.1_Silent_p.D129D	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	129					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	TCTGTAAAGATGTAGTTTCAA	0.338000													33	70					0	0	1	0	0
ERV3-1	2086	broad.mit.edu	37	7	64452411	64452411	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:64452411T>A	ENST00000394323.2	-	2	1494	c.994A>T	c.(994-996)Agc>Tgc	p.S332C		NM_001007253.3	NP_001007254.2	Q14264	ENR1_HUMAN		332						virion				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)	16						aaccagatgctctgacttgat	0.473000													17	28					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42489324	42489324	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:42489324C>A	ENST00000545399.1	-	8	931	c.778G>T	c.(778-780)Gtg>Ttg	p.V260L	ATP1A3_ENST00000543770.1_Missense_Mutation_p.V258L|ATP1A3_ENST00000602133.1_Missense_Mutation_p.V217L|ATP1A3_ENST00000302102.5_Missense_Mutation_p.V247L	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	247					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						GCCACCACCACGCCCCGAGCC	0.677000													11	20					1.08611e-07	1.21755e-07	1	1	0
KIF26A	26153	broad.mit.edu	37	14	104640061	104640061	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:104640061G>T	ENST00000315264.7	+	9	1847	c.1469G>T	c.(1468-1470)cGc>cTc	p.R490L	KIF26A_ENST00000423312.2_Missense_Mutation_p.R629L			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	629	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GGCCGCAGCCGCCTGCACCTC	0.697000													8	17					0.000157383	0.000166197	1	1	0
ASH1L	55870	broad.mit.edu	37	1	155313242	155313242	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:155313242C>G	ENST00000368346.3	-	24	8810	c.8171G>C	c.(8170-8172)cGt>cCt	p.R2724P	ASH1L_ENST00000392403.3_Missense_Mutation_p.R2719P			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2724	BAH.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTCGTGGGGACGGAAATAATG	0.463000													19	64					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265578	3265578	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:3265578G>A	ENST00000520002.1	-	15	2472	c.1917C>T	c.(1915-1917)ctC>ctT	p.L639L	CSMD1_ENST00000539096.1_Silent_p.L638L|CSMD1_ENST00000537824.1_Silent_p.L638L|CSMD1_ENST00000602723.1_Silent_p.L639L|CSMD1_ENST00000400186.3_Silent_p.L639L|CSMD1_ENST00000602557.1_Silent_p.L639L|CSMD1_ENST00000542608.1_Silent_p.L638L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	639	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTTGACCGCGAGAAAGTCAA	0.458000													12	20					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	69281720	69281720	+	Splice_Site	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:69281720C>A	ENST00000433211.1	-	5	634		c.e5-1		CTNNA3_ENST00000545309.1_Splice_Site|CTNNA3_ENST00000373744.4_Splice_Site	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3						cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TCCTTTGAAACTGAAATTGAA	0.378000													19	44					5.03518e-11	6.05598e-11	1	1	0
DLG3	1741	broad.mit.edu	37	X	69671762	69671762	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:69671762T>G	ENST00000194900.4	+	8	1426	c.1085T>G	c.(1084-1086)cTg>cGg	p.L362R	DLG3_ENST00000374360.3_Missense_Mutation_p.L344R			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	344					axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					AATTCCAGCCTGGGTTATCTC	0.552000											OREG0019853	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	33					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52284441	52284441	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:52284441C>A	ENST00000356297.4	-	19	3993	c.3893G>T	c.(3892-3894)tGc>tTc	p.C1298F	PXDNL_ENST00000543296.1_Missense_Mutation_p.C1298F	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1298					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACCTGCACAGCAGTCTTGCCA	0.458000													10	23					7.48243e-07	8.29984e-07	1	1	0
P2RX2	22953	broad.mit.edu	37	12	133195507	133195507	+	Splice_Site	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:133195507G>A	ENST00000352418.4	+	1	105	c.105_splice	c.e1+1	p.V35_splice	P2RX2_ENST00000449132.2_Silent_p.V35V|P2RX2_ENST00000389110.3_Silent_p.V35V|P2RX2_ENST00000351222.4_Splice_Site_p.V35_splice|P2RX2_ENST00000350048.5_Silent_p.V35V|P2RX2_ENST00000348800.5_Silent_p.V35V|P2RX2_ENST00000343948.4_Silent_p.V35V	NM_012226.3	NP_036358.2	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 2	35					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity			NS(1)|breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(8)|ovary(1)|prostate(3)	20	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		AGGTGATCGTGGTGAGGAACC	0.756000													11	23					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176664955	176664955	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:176664955G>A	ENST00000367662.3	+	7	3870	c.2706G>A	c.(2704-2706)gtG>gtA	p.V902V		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	902					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCCGGCGGGTGTGTGACTCCT	0.552000													28	60					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146070764	146070764	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:146070764T>A	ENST00000394413.3	-	4	944	c.374A>T	c.(373-375)aAg>aTg	p.K125M	PPP2R2B_ENST00000394409.3_Missense_Mutation_p.K183M|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.K125M|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.K131M|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.K114M|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.K125M|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.K114M|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.K125M|PPP2R2B_ENST00000394414.1_Missense_Mutation_p.K191M|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.K128M			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	125					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTGGCCTCTTATCACGCTC	0.512000													33	44					0	0	1	0	0
ZNF582	147948	broad.mit.edu	37	19	56895481	56895481	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:56895481G>T	ENST00000301310.4	-	5	1463	c.1305C>A	c.(1303-1305)tgC>tgA	p.C435*	ZNF582_ENST00000586929.1_Nonsense_Mutation_p.C435*	NM_144690.1	NP_653291.1	Q96NG8	ZN582_HUMAN	zinc finger protein 582	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		TCAATTGTGAGCAATGACTAA	0.393000													34	72					2.20474e-14	2.84621e-14	1	1	0
MLLT6	4302	broad.mit.edu	37	17	36881840	36881840	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:36881840G>T	ENST00000325718.7	+	20	3362	c.3271G>T	c.(3271-3273)Gaa>Taa	p.E1091*		NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	1091					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					AGCCAACCAGGAAAAAGGCTA	0.607000			T	MLL	AL								10	18					0.010729	0.0110428	1	1	0
MCF2	4168	broad.mit.edu	37	X	138679741	138679741	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:138679741G>T	ENST00000520602.1	-	21	2398	c.2113C>A	c.(2113-2115)Cta>Ata	p.L705I	MCF2_ENST00000370573.4_Missense_Mutation_p.L645I|MCF2_ENST00000370576.4_Missense_Mutation_p.L645I|MCF2_ENST00000536274.1_Missense_Mutation_p.L606I|MCF2_ENST00000370578.4_Missense_Mutation_p.L790I|MCF2_ENST00000519895.1_Missense_Mutation_p.L721I|MCF2_ENST00000338585.6_Missense_Mutation_p.L661I|MCF2_ENST00000414978.1_Missense_Mutation_p.L705I			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	645	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TATTTTAATAGCTCCTGTAAT	0.343000													21	38					2.08468e-23	3.04063e-23	1	1	0
TOX2	84969	broad.mit.edu	37	20	42679949	42679949	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:42679949C>T	ENST00000358131.5	+	4	650	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	TOX2_ENST00000435864.2_Nonsense_Mutation_p.Q17*|TOX2_ENST00000372999.1_Nonsense_Mutation_p.Q97*|TOX2_ENST00000341197.3_Nonsense_Mutation_p.Q139*|TOX2_ENST00000423191.1_Nonsense_Mutation_p.Q97*	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CTCTTAGATCCAGGAGATGGT	0.612000													21	65					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66928653	66928653	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:66928653G>A	ENST00000269080.2	-	6	710	c.573C>T	c.(571-573)atC>atT	p.I191I	ABCA8_ENST00000430352.2_Silent_p.I191I|ABCA8_ENST00000586539.1_Silent_p.I191I	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	191						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GATTTGTTGTGATCTGAAGAA	0.348000													50	36					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197890558	197890558	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:197890558C>G	ENST00000367390.3	+	4	502	c.475C>G	c.(475-477)Ctg>Gtg	p.L159V	LHX9_ENST00000367387.4_Missense_Mutation_p.L168V|LHX9_ENST00000337020.2_Missense_Mutation_p.L168V|LHX9_ENST00000561173.1_Missense_Mutation_p.L174V|LHX9_ENST00000367391.1_Missense_Mutation_p.L159V	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	168	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						CAACAAGACTCTGACCACGGG	0.602000													25	62					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127597489	127597489	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:127597489T>C	ENST00000508053.1	-	70	9277	c.8303A>G	c.(8302-8304)aAc>aGc	p.N2768S	FBN2_ENST00000262464.4_Missense_Mutation_p.N2768S			P35556	FBN2_HUMAN	fibrillin 2	2768					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGAATAGCCGTTGATTTTGCA	0.453000													38	90					0	0	1	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27834798	27834798	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:27834798C>A	ENST00000331442.3	-	1	561	c.510G>T	c.(508-510)gtG>gtT	p.V170V		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	170					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						GGCTCTTCGCCACCTTTTTGA	0.592000													61	127					5.47352e-35	8.42571e-35	1	1	0
RTP1	132112	broad.mit.edu	37	3	186917551	186917551	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:186917551G>A	ENST00000312295.4	+	2	515	c.485G>A	c.(484-486)cGc>cAc	p.R162H	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	162					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		ACCAGCCTGCGCGAGCAGTGC	0.677000													20	42					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147128358	147128358	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:147128358C>T	ENST00000282928.4	+	1	1188	c.459C>T	c.(457-459)caC>caT	p.H153H		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	153					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						CTGCCGGCCACGCGTCGCCTA	0.711000													7	26					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840035	27840035	+	Silent	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:27840035G>C	ENST00000356790.2	+	3	857	c.612G>C	c.(610-612)ctG>ctC	p.L204L		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	204	MAGE.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						CTGGCCTGCTGATGACTGTCC	0.463000													19	40					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185018518	185018518	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:185018518G>T	ENST00000296741.2	-	7	1138	c.997C>A	c.(997-999)Cga>Aga	p.R333R		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	333					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		AGCATCTCTCGATTCTGAAAC	0.612000													16	18					1.15088e-07	1.2847e-07	1	1	0
TMEM200A	114801	broad.mit.edu	37	6	130762678	130762678	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:130762678C>G	ENST00000392429.1	+	2	3489	c.1111C>G	c.(1111-1113)Cag>Gag	p.Q371E	TMEM200A_ENST00000545622.1_Missense_Mutation_p.Q371E|TMEM200A_ENST00000296978.3_Missense_Mutation_p.Q371E	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	371						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TGGGGCTGGACAGCTCTTGTC	0.537000													22	53					0	0	1	0	0
RAMP3	10268	broad.mit.edu	37	7	45222991	45222991	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:45222991C>T	ENST00000242249.4	+	3	465	c.427C>T	c.(427-429)Cgc>Tgc	p.R143C	RAMP3_ENST00000481345.1_Missense_Mutation_p.R143C|RAMP3_ENST00000496212.1_Missense_Mutation_p.R143C	NM_005856.2	NP_005847.1	O60896	RAMP3_HUMAN	receptor (G protein-coupled) activity modifying protein 3	143					intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity			breast(1)|endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	11					Pramlintide(DB01278)	GCGCAGCAAACGCACCGACAC	0.627000													59	48					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161953981	161953981	+	Silent	SNP	G	G	T	rs142854687		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:161953981G>T	ENST00000294794.3	-	8	2160	c.1737C>A	c.(1735-1737)cgC>cgA	p.R579R	OLFML2B_ENST00000367938.1_Silent_p.R62R|OLFML2B_ENST00000367940.2_Silent_p.R580R	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	579	Olfactomedin-like.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGGTGAAGGCGCGATTGTAGT	0.607000													31	61					1.75199e-13	2.19726e-13	1	1	0
GPLD1	2822	broad.mit.edu	37	6	24467009	24467009	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:24467009C>A	ENST00000230036.1	-	10	830	c.720G>T	c.(718-720)gtG>gtT	p.V240V	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	240						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						GGAATTGTTCCACCAAAAACG	0.363000													16	37					5.3912e-06	5.86919e-06	1	1	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229360	90229360	+	RNA	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:90229360G>T	ENST00000390278.2	+	0	200																											GGTATCTGCAGAAACCAGGGA	0.493000													26	67					1.75199e-13	2.19726e-13	1	1	0
CHST13	166012	broad.mit.edu	37	3	126260799	126260799	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:126260799C>G	ENST00000319340.2	+	3	454	c.404C>G	c.(403-405)cCg>cGg	p.P135R		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	135					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		CGCGGCGACCCGCGCGCCATC	0.721000													11	25					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296282	39296282	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr17:39296282G>T	ENST00000345847.4	-	1	457	c.458C>A	c.(457-459)tCt>tAt	p.S153Y		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	149	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ttcacagcaagaggggcggca	0.662000													4	77					4.096e-09	4.75316e-09	1	1	0
ZNF804A	91752	broad.mit.edu	37	2	185802541	185802541	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:185802541C>A	ENST00000302277.6	+	4	3012	c.2418C>A	c.(2416-2418)tgC>tgA	p.C806*		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	806						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTGCTCCCTGCAAGCCTAAAA	0.383000													31	46					3.90053e-15	5.06014e-15	1	1	0
FLNC	2318	broad.mit.edu	37	7	128488974	128488974	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:128488974C>T	ENST00000325888.8	+	28	5126	c.4865C>T	c.(4864-4866)cCc>cTc	p.P1622L	FLNC_ENST00000346177.6_Missense_Mutation_p.P1622L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1622					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GATGAGATCCCCTACTCGCCC	0.622000													33	70					0	0	1	0	0
SEPT6	23157	broad.mit.edu	37	X	118771044	118771044	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:118771044C>G	ENST00000394610.1	-	7	1166	c.902G>C	c.(901-903)tGt>tCt	p.C301S	SEPT6_ENST00000354416.3_Missense_Mutation_p.C301S|SEPT6_ENST00000360156.7_Missense_Mutation_p.C301S|SEPT6_ENST00000343984.5_Missense_Mutation_p.C301S|SEPT6_ENST00000354228.4_Missense_Mutation_p.C301S|SEPT6_ENST00000489216.1_Missense_Mutation_p.C301S|SEPT6_ENST00000394616.4_Missense_Mutation_p.C243S|SEPT6_ENST00000394617.2_Missense_Mutation_p.C331S	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	301					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						CTCCAGCTTACAGCGGCGATA	0.612000			T	MLL	AML								23	64					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55615193	55615193	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:55615193C>A	ENST00000326258.1	+	1	385	c.385C>A	c.(385-387)Cct>Act	p.P129T		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CATCTGTAACCCTCTCCATTA	0.473000													37	63					6.97489e-18	9.39475e-18	1	1	0
MED7	9443	broad.mit.edu	37	5	156566212	156566212	+	Silent	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:156566212T>C	ENST00000286317.5	-	2	612	c.231A>G	c.(229-231)gaA>gaG	p.E77E	MED7_ENST00000420343.1_Silent_p.E77E	NM_004270.4	NP_004261.1	O43513	MED7_HUMAN	mediator complex subunit 7	77					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity			kidney(1)|large_intestine(1)|lung(3)|urinary_tract(2)	7	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTTTCTCAGTTCTTTCTTGT	0.378000													34	74					0	0	1	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58189861	58189861	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:58189861C>T	ENST00000318203.5	+	5	1587	c.890C>T	c.(889-891)aCa>aTa	p.T297I		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	297					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAAATTCCACATGTGAGGTA	0.478000													25	59					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6638760	6638760	+	Splice_Site	SNP	G	G	T	rs111952025		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:6638760G>T	ENST00000315579.5	+	28	4452		c.e28+1		NCAPD2_ENST00000545962.1_Splice_Site	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2						cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						GCACATCCCGGTATGCTGCCC	0.607000													21	67					1.9806e-07	2.20624e-07	1	1	0
DNAJC11	55735	broad.mit.edu	37	1	6705119	6705119	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:6705119C>A	ENST00000377577.5	-	9	1085	c.962G>T	c.(961-963)cGt>cTt	p.R321L	DNAJC11_ENST00000294401.7_Missense_Mutation_p.R321L|DNAJC11_ENST00000377573.5_Missense_Mutation_p.R231L|DNAJC11_ENST00000349363.6_Intron|DNAJC11_ENST00000542246.1_Missense_Mutation_p.R283L	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	321					protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTTTCACACGAGTCTGATC	0.522000													68	166					4.8811e-34	7.4702e-34	1	1	0
H2BFM	286436	broad.mit.edu	37	X	103294763	103294763	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:103294763G>T	ENST00000243297.5	+	3	529	c.529G>T	c.(529-531)Ggc>Tgc	p.G177C	H2BFM_ENST00000355016.3_Missense_Mutation_p.G74C					H2B histone family, member M											endometrium(1)|lung(1)|ovary(1)	3						GGTTCACCAGGGCCTCAGCCT	0.632000													5	6					0.014758	0.0151305	1	1	0
ESX1	80712	broad.mit.edu	37	X	103498900	103498900	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:103498900C>A	ENST00000372588.4	-	2	524	c.441G>T	c.(439-441)acG>acT	p.T147T		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	147					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GCTGAAACTGCGTGAACGCGG	0.642000													39	93					3.09479e-21	4.38082e-21	1	1	0
MUC16	94025	broad.mit.edu	37	19	8993474	8993474	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:8993474C>A	ENST00000397910.4	-	66	41818	c.41615G>T	c.(41614-41616)gGg>gTg	p.G13872V	MUC16_ENST00000380951.5_Missense_Mutation_p.G513V	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13875	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGTCCAGCCCAGGGCCTGT	0.597000													42	44					2.66277e-13	3.33161e-13	1	1	0
PXDNL	137902	broad.mit.edu	37	8	52384784	52384784	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:52384784C>G	ENST00000356297.4	-	8	875	c.775G>C	c.(775-777)Gga>Cga	p.G259R	PXDNL_ENST00000543296.1_Missense_Mutation_p.G259R	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	259	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTGGGGTTTCCTTCCGCCCGG	0.448000													35	58					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16267025	16267025	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:16267025G>T	ENST00000343518.6	-	9	1475	c.1424C>A	c.(1423-1425)aCt>aAt	p.T475N		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	475										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						ATTGTCAGCAGTGGCACCGTT	0.408000													46	489					2.84144e-21	4.03301e-21	1	1	0
ANK2	287	broad.mit.edu	37	4	114280093	114280093	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:114280093C>G	ENST00000357077.4	+	38	10372	c.10319C>G	c.(10318-10320)tCc>tGc	p.S3440C	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.S3407C	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3407					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATACTTACATCCCGATTGCCA	0.478000													18	45					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149115939	149115939	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:149115939A>C	ENST00000355292.3	-	4	2346	c.1984T>G	c.(1984-1986)Tgc>Ggc	p.C662G	NR3C2_ENST00000503313.1_5'UTR|NR3C2_ENST00000511528.1_Missense_Mutation_p.C662G|NR3C2_ENST00000342437.4_Missense_Mutation_p.C658G|RP11-76G10.1_ENST00000514843.1_RNA|NR3C2_ENST00000358102.3_Missense_Mutation_p.C658G|NR3C2_ENST00000512865.1_Missense_Mutation_p.C658G|NR3C2_ENST00000344721.4_Missense_Mutation_p.C658G			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	658					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TGAAGTCTGCAAGCAGGACAA	0.308000													40	74					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23731410	23731410	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:23731410C>T	ENST00000304749.2	-	1	164	c.94G>A	c.(94-96)Ggt>Agt	p.G32S	CST1_ENST00000398402.1_Missense_Mutation_p.G32S	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	32		Reactive site.				extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					TAGATGCCACCCGGGATTATC	0.567000													19	43					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113266529	113266529	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:113266529G>T	ENST00000297405.5	-	63	10307	c.10063C>A	c.(10063-10065)Cca>Aca	p.P3355T	CSMD3_ENST00000352409.3_Missense_Mutation_p.P3285T|CSMD3_ENST00000455883.2_Missense_Mutation_p.P3186T|CSMD3_ENST00000343508.3_Missense_Mutation_p.P3315T	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3355	Sushi 27.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GGCACACCTGGGTTTTCACAA	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			54	103					3.76997e-23	5.46852e-23	1	1	0
DBX2	440097	broad.mit.edu	37	12	45410190	45410190	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:45410190T>C	ENST00000332700.6	-	4	1070	c.899A>G	c.(898-900)gAa>gGa	p.E300G		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	300						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GATTAGTCTTTCTGAAGGTTC	0.498000													27	59					0	0	1	0	0
KDELR1	10945	broad.mit.edu	37	19	48887696	48887696	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:48887696A>G	ENST00000597017.1	-	3	634	c.209T>C	c.(208-210)tTg>tCg	p.L70S	KDELR1_ENST00000330720.2_Missense_Mutation_p.L132S			P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	132					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|pancreas(1)|urinary_tract(1)	11		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		CAGCTGCGGCAAGATGGCCAC	0.587000													11	23					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134664626	134664626	+	Missense_Mutation	SNP	C	C	A	rs143825819	byFrequency	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:134664626C>A	ENST00000368586.5	-	40	5858	c.5758G>T	c.(5758-5760)Ggc>Tgc	p.G1920C	TTC40_ENST00000263170.5_Missense_Mutation_p.G81C	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	81										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						ATTACCAGGCCGACGGAAGTG	0.632000													21	69					5.26018e-13	6.55041e-13	1	1	0
OR6F1	343169	broad.mit.edu	37	1	247875300	247875300	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:247875300C>T	ENST00000302084.2	-	1	805	c.758G>A	c.(757-759)gGg>gAg	p.G253E	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G253L(1)		breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AACTGTGGACCCATACCAAAT	0.527000													48	61					0	0	1	0	0
CYP26A1	1592	broad.mit.edu	37	10	94834754	94834754	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:94834754G>A	ENST00000371531.1	+	3	804	c.426G>A	c.(424-426)gtG>gtA	p.V142V	CYP26A1_ENST00000224356.4_Silent_p.V211V|CYP26A1_ENST00000394139.1_Silent_p.V142V	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	211					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				AGCAGCTTGTGGAGGCCTTCG	0.642000													37	75					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65489738	65489738	+	Silent	SNP	C	C	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:65489738C>G	ENST00000261883.4	-	9	3052	c.2886G>C	c.(2884-2886)ggG>ggC	p.G962G		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	962					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						CTTCCAGTGGCCCCACAATCT	0.542000													25	65					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164727128	164727128	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:164727128C>T	ENST00000264382.3	-	35	4180	c.4118G>A	c.(4117-4119)tGg>tAg	p.W1373*		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1373	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCTGGCCCACCACTCTGCTGT	0.378000										HNSCC(35;0.089)			22	58					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247655221	247655221	+	RNA	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:247655221A>G	ENST00000522351.1	+	0	852							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AAGCCGGCCAACAGCTACTCC	0.522000													60	70					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177190254	177190254	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:177190254C>A	ENST00000296525.3	-	1	119	c.6G>T	c.(4-6)tcG>tcT	p.S2S		NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	2					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		CTTCTAACACCGACATTGCTG	0.458000													28	34					4.22769e-11	5.11978e-11	1	1	0
FAM47C	442444	broad.mit.edu	37	X	37027083	37027083	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:37027083G>T	ENST00000358047.3	+	1	652	c.600G>T	c.(598-600)ccG>ccT	p.P200P		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	200										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GTCTCCCCCCGGAGCCTCCCA	0.642000													11	51					1.08611e-07	1.21755e-07	1	1	0
NDST1	3340	broad.mit.edu	37	5	149927844	149927844	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:149927844G>T	ENST00000261797.6	+	12	2712	c.2210G>T	c.(2209-2211)gGc>gTc	p.G737V	NDST1_ENST00000523767.1_Intron	NM_001543.4	NP_001534.1	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	737	Heparan sulfate N-sulfotransferase 1.				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTACCGCCGGCTCTGACGCA	0.627000													25	51					0.000720815	0.000753644	1	1	0
NDST1	3340	broad.mit.edu	37	5	149927843	149927843	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:149927843G>C	ENST00000261797.6	+	12	2711	c.2209G>C	c.(2209-2211)Ggc>Cgc	p.G737R	NDST1_ENST00000523767.1_Intron	NM_001543.4	NP_001534.1	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	737	Heparan sulfate N-sulfotransferase 1.				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GATTACCGCCGGCTCTGACGC	0.622000													25	50					0	0	1	0	0
DDX51	317781	broad.mit.edu	37	12	132627289	132627289	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:132627289G>T	ENST00000397333.3	-	3	692	c.654C>A	c.(652-654)atC>atA	p.I218I		NM_175066.3	NP_778236.2	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	218					rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			endometrium(1)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		AGTAGGACGAGATGCCGTGTG	0.617000													28	51					4.43304e-23	6.41272e-23	1	1	0
FOXO1	2308	broad.mit.edu	37	13	41134046	41134046	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr13:41134046C>A	ENST00000379561.5	-	2	1966	c.1582G>T	c.(1582-1584)Gct>Tct	p.A528S		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	528					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		GTCTGCTGAGCATGTCCAGGG	0.557000													36	35					2.05212e-20	2.87405e-20	1	1	0
KCNU1	157855	broad.mit.edu	37	8	36675183	36675183	+	Nonsense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:36675183T>A	ENST00000399881.3	+	10	1048	c.1011T>A	c.(1009-1011)tgT>tgA	p.C337*		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	337						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TTGTGGTCTGTGGAAACATCA	0.453000													33	29					0	0	1	0	0
EXOSC1	51013	broad.mit.edu	37	10	99203063	99203063	+	Silent	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:99203063T>A	ENST00000370902.3	-	3	184	c.153A>T	c.(151-153)ccA>ccT	p.P51P	EXOSC1_ENST00000471049.1_5'UTR|EXOSC1_ENST00000370885.4_Intron|EXOSC1_ENST00000485122.2_Silent_p.P51P|EXOSC1_ENST00000370886.5_Silent_p.P51P	NM_016046.3	NP_057130.1	Q9Y3B2	EXOS1_HUMAN	exosome component 1	51					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding			breast(1)|endometrium(1)|lung(5)	7		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		CAGACACCACTGGAAGCTACA	0.438000													54	114					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40587217	40587217	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:40587217C>T	ENST00000260402.3	-	18	2075	c.1826G>A	c.(1825-1827)cGc>cAc	p.R609H	PLCB2_ENST00000557821.1_Missense_Mutation_p.R605H|PLCB2_ENST00000456256.2_Missense_Mutation_p.R609H	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	609	PI-PLC Y-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GGAGTCCATGCGGGTTCCCTT	0.567000													107	61					0	0	1	0	0
UGT1A8	54576	broad.mit.edu	37	2	234526584	234526584	+	Silent	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:234526584C>T	ENST00000373450.4	+	1	294	c.231C>T	c.(229-231)taC>taT	p.Y77Y		NM_019076.4	NP_061949.3														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGAAGACTTACTCAACCTCAT	0.463000													63	107					0	0	1	0	0
TRAV3	28690	broad.mit.edu	37	14	22192375	22192375	+	RNA	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:22192375T>A	ENST00000390425.2	+	0	326																											CTGGAAACCCTTATCTTTTTT	0.483000													32	61					0	0	1	0	0
FAM174B	400451	broad.mit.edu	37	15	93173525	93173525	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:93173525G>A	ENST00000327355.5	-	2	693	c.395C>T	c.(394-396)cCa>cTa	p.P132L	FAM174B_ENST00000555748.1_5'UTR|FAM174B_ENST00000555064.1_5'UTR|FAM174B_ENST00000553393.1_5'UTR|FAM174B_ENST00000555696.1_5'UTR	NM_207446.2	NP_997329.2	Q3ZCQ3	F174B_HUMAN	family with sequence similarity 174, member B	132						integral to membrane				endometrium(2)|lung(1)	3						TCGCTCTGCTGGAGTGGTGAT	0.473000													27	17					0	0	1	0	0
CDH3	1001	broad.mit.edu	37	16	68718695	68718695	+	Silent	SNP	A	A	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:68718695A>G	ENST00000264012.4	+	10	1936	c.1392A>G	c.(1390-1392)gcA>gcG	p.A464A	CDH3_ENST00000429102.2_Silent_p.A464A|CDH3_ENST00000581171.1_Silent_p.A409A	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	464	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		TCTACACTGCAGAAGACCCTG	0.547000													114	46					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131172131	131172131	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:131172131T>A	ENST00000357668.1	-	11	1016	c.989A>T	c.(988-990)tAc>tTc	p.Y330F	ASAP1_ENST00000518721.1_Missense_Mutation_p.Y330F			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	330	PH.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						CTTTAGCAGGTACCCCTTCTT	0.453000													34	101					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155099299	155099299	+	Silent	SNP	A	A	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:155099299A>T	ENST00000392825.3	+	6	1134	c.567A>T	c.(565-567)atA>atT	p.I189I	GALNT13_ENST00000409237.1_Silent_p.I189I	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	189	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						CTGGGTTAATACGTGCCCGTC	0.423000													21	44					0	0	1	0	0
TTLL7	79739	broad.mit.edu	37	1	84403604	84403604	+	Silent	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:84403604G>A	ENST00000260505.8	-	8	1196	c.819C>T	c.(817-819)tcC>tcT	p.S273S	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	273	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ACCATTTGATGGAACGTTTGC	0.373000													44	41					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395430	49395430	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:49395430C>A	ENST00000419349.1	-	1	286	c.282G>T	c.(280-282)ggG>ggT	p.G94G	GPX1_ENST00000419783.1_Intron|GPX1_ENST00000496791.1_Intron	NM_201397.1	NP_958799.1	P07203	GPX1_HUMAN	glutathione peroxidase 1	185					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	GCACGTCCGCccccgccccgc	0.716000													3	7					1	1	1	1	0
FAT4	79633	broad.mit.edu	37	4	126239735	126239735	+	Silent	SNP	T	T	G			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:126239735T>G	ENST00000394329.3	+	1	2182	c.2169T>G	c.(2167-2169)acT>acG	p.T723T		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	723	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCAATGGTACTGTCAAATATA	0.473000													23	52					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21051404	21051404	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:21051404G>C	ENST00000381545.3	+	14	1936	c.1717G>C	c.(1717-1719)Ggt>Cgt	p.G573R	SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G573R|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G573R|LST3_ENST00000540229.1_Missense_Mutation_p.G573R|LST3_ENST00000381541.3_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	573					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ACTTGCAATGGGTTTCCAGTC	0.264000													29	76					0	0	1	0	0
CREG1	8804	broad.mit.edu	37	1	167515387	167515387	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:167515387C>A	ENST00000370509.4	-	3	635	c.610G>T	c.(610-612)Ggt>Tgt	p.G204C	CREG1_ENST00000466652.1_5'UTR	NM_003851.2	NP_003842.1	O75629	CREG1_HUMAN	cellular repressor of E1A-stimulated genes 1	204					cell proliferation|multicellular organismal development|regulation of growth|regulation of transcription from RNA polymerase II promoter	extracellular region	FMN binding|transcription corepressor activity										TTTGGTCCACCAAAGTAGTCC	0.413000													13	39					5.50884e-06	5.98491e-06	1	1	0
TRIP11	9321	broad.mit.edu	37	14	92505994	92505994	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:92505994C>A	ENST00000267622.4	-	1	409	c.36G>T	c.(34-36)ttG>ttT	p.L12F	TRIP11_ENST00000555105.1_5'UTR	NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	12					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		GAGACTGGCCCAATCCGGAGC	0.602000			T	PDGFRB	AML								9	12					0.0581538	0.0589351	1	1	0
MIR154	406946	broad.mit.edu	37	14	101526116	101526116	+	RNA	SNP	G	G	T	rs150222739	by1000genomes	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr14:101526116G>T	ENST00000385243.1	+	0	25					NR_029704.1																						TAGGTTATCCGTGTTGCCTTC	0.502000													93	230					4.95785e-36	7.69924e-36	1	1	0
NAALADL2	254827	broad.mit.edu	37	3	174814852	174814852	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:174814852T>A	ENST00000454872.1	+	2	444	c.316T>A	c.(316-318)Tac>Aac	p.Y106N	NAALADL2_ENST00000473253.1_3'UTR|NAALADL2-AS3_ENST00000453180.1_RNA	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	106					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AGAATCTGACTACATTACCCA	0.408000													20	79					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18629092	18629092	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr18:18629092C>A	ENST00000399799.1	-	4	1315	c.375G>T	c.(373-375)agG>agT	p.R125S		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	125	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					CCATGATGTCCCTTTCTTCCC	0.383000													82	24					3.1711e-36	4.95366e-36	1	1	0
SLC2A13	114134	broad.mit.edu	37	12	40265747	40265747	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:40265747T>A	ENST00000280871.4	-	5	1101	c.1051A>T	c.(1051-1053)Att>Ttt	p.I351F		NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	351						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				ATCTGCAGAATGGTTGCACTG	0.373000										HNSCC(50;0.14)			26	42					0	0	1	0	0
ZPBP	11055	broad.mit.edu	37	7	50022996	50022996	+	Silent	SNP	G	G	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:50022996G>C	ENST00000046087.2	-	7	972	c.903C>G	c.(901-903)cgC>cgG	p.R301R	ZPBP_ENST00000491129.1_5'UTR|ZPBP_ENST00000419417.1_Silent_p.R300R	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	301					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					CTGGAAAGCAGCGATTAATCC	0.338000													17	379					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46515686	46515686	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr11:46515686C>T	ENST00000458649.2	-	10	2826	c.2408G>A	c.(2407-2409)cGc>cAc	p.R803H	AMBRA1_ENST00000529963.1_5'UTR|AMBRA1_ENST00000298834.3_Missense_Mutation_p.R743H|AMBRA1_ENST00000426438.1_Missense_Mutation_p.R774H|AMBRA1_ENST00000534300.1_Missense_Mutation_p.R743H|AMBRA1_ENST00000533727.1_Missense_Mutation_p.R684H|AMBRA1_ENST00000528950.1_Missense_Mutation_p.R774H|AMBRA1_ENST00000314845.3_Missense_Mutation_p.R713H			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	803					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		TGGGACAAAGCGTCCAAGCGA	0.468000													10	1					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98799785	98799785	+	Silent	SNP	G	G	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:98799785G>T	ENST00000266058.4	-	21	2502	c.2257C>A	c.(2257-2259)Cgg>Agg	p.R753R	SLIT1_ENST00000371070.4_Silent_p.R753R|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	753	LRRNT 4.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GGCAGGGCCCGCAGGTGCTTG	0.662000													12	39					4.3838e-07	4.87294e-07	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113312289	113312289	+	Silent	SNP	C	C	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:113312289C>A	ENST00000401783.2	-	2	963	c.627G>T	c.(625-627)gcG>gcT	p.A209A	SVEP1_ENST00000302728.8_Silent_p.A209A|SVEP1_ENST00000374469.1_Silent_p.A186A|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374461.1_Silent_p.A186A	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	209	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCGCAGTGACGCTGCAATTG	0.453000													36	27					7.11191e-15	9.20364e-15	1	1	0
ATXN2L	11273	broad.mit.edu	37	16	28841988	28841988	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:28841988G>A	ENST00000336783.4	+	9	1254	c.1087G>A	c.(1087-1089)Gga>Aga	p.G363R	ATXN2L_ENST00000382686.4_Missense_Mutation_p.G363R|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000570200.1_Missense_Mutation_p.G363R|ATXN2L_ENST00000564304.1_Missense_Mutation_p.G363R|ATXN2L_ENST00000340394.8_Missense_Mutation_p.G363R|ATXN2L_ENST00000325215.6_Missense_Mutation_p.G363R|ATXN2L_ENST00000395547.2_Missense_Mutation_p.G363R	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	363						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						TCCCCGGGGAGGAGTTCGATG	0.602000													10	50					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907671	12907671	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:12907671delT	ENST00000317869.6	-	2	697	c.472delA	c.(472-474)gtfs	p.S158fs		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TTGAAGCCACTTTTGCCCCTT	0.502													72	163	---	---	---	---					
COL11A1	1301	broad.mit.edu	37	1	103461597	103461597	+	Splice_Site	DEL	C	C	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:103461597delC	ENST00000358392.2	-	27	2596	c.2277_splice	c.e27-1	p.G760_splice	COL11A1_ENST00000370096.3_Splice_Site_p.G748_splice|COL11A1_ENST00000353414.4_Splice_Site_p.G709_splice|COL11A1_ENST00000512756.1_Splice_Site_p.G632_splice	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	748	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCAGGGGGACCCTGAAATAG	0.363													42	38	---	---	---	---					
FCRL5	83416	broad.mit.edu	37	1	157508906	157508906	+	Frame_Shift_Del	DEL	G	G	-	rs149906130	byFrequency	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:157508906delG	ENST00000361835.3	-	7	1529	c.1372delC	c.(1372-1374)gcfs	p.R458fs	FCRL5_ENST00000368191.3_Frame_Shift_Del_p.R373fs|FCRL5_ENST00000368190.3_Frame_Shift_Del_p.R458fs|FCRL5_ENST00000368189.3_Frame_Shift_Del_p.R458fs|FCRL5_ENST00000356953.4_Frame_Shift_Del_p.R458fs	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	458	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GCCTTACTGCGCTGGGGGCCA	0.582													13	48	---	---	---	---					
SMG7	9887	broad.mit.edu	37	1	183518986	183518987	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:183518986_183518987insT	ENST00000367537.3	+	21	3205_3206	c.3010_3011insT	c.(3010-3012)cccfs	p.P1004fs	SMG7_ENST00000515829.2_Frame_Shift_Ins_p.P925fs|SMG7_ENST00000456731.2_Frame_Shift_Ins_p.P883fs|SMG7_ENST00000508461.1_Frame_Shift_Ins_p.P979fs|SMG7_ENST00000507469.1_Frame_Shift_Ins_p.P975fs|SMG7_ENST00000347615.2_Frame_Shift_Ins_p.P971fs			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	971	Ser-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TCCCTCAATGGCCCCCCAGGAA	0.426													41	88	---	---	---	---					
TRIM58	25893	broad.mit.edu	37	1	248028102	248028102	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr1:248028102delG	ENST00000366481.3	+	3	660	c.612delG	c.(610-612)ctfs	p.L204fs		NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	204						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGAGGCGGCTGGAGGCGGAGG	0.627													25	48	---	---	---	---					
ZAP70	7535	broad.mit.edu	37	2	98340826	98340827	+	Frame_Shift_Ins	INS	-	-	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:98340826_98340827insC	ENST00000264972.5	+	3	542_543	c.327_328insC	c.(325-330)gacgcafs	p.A110fs		NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	110	Interdomain A.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CGGGCCTCGAGCCGCAGCCGGG	0.713													12	15	---	---	---	---					
ACOXL	55289	broad.mit.edu	37	2	111789238	111789238	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr2:111789238delG	ENST00000389811.4	+	16	1630	c.1406delG	c.(1405-1407)tgfs	p.W469fs	ACOXL_ENST00000439055.1_Frame_Shift_Del_p.W439fs			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	469					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						TTCCATGCCTGGAACTCGTGT	0.463													46	72	---	---	---	---					
SCN11A	11280	broad.mit.edu	37	3	38888292	38888293	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:38888292_38888293insT	ENST00000450244.1	-	26	5466_5467	c.5268_5269insA	c.(5266-5271)cagtgafs	p.*1757fs	SCN11A_ENST00000456224.3_Frame_Shift_Ins_p.*1719fs|SCN11A_ENST00000302328.3_Frame_Shift_Ins_p.*1757fs			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1757					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTttggtcaccttggtcaccct	0.490													42	42	---	---	---	---					
TAGLN3	29114	broad.mit.edu	37	3	111718280	111718280	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:111718280delG	ENST00000393917.2	+	2	563	c.11delG	c.(10-12)agfs	p.R4fs	TAGLN3_ENST00000478951.1_Frame_Shift_Del_p.R4fs|TAGLN3_ENST00000273368.4_Frame_Shift_Del_p.R4fs|TAGLN3_ENST00000455401.2_Frame_Shift_Del_p.R4fs	NM_013259.2	NP_037391.2	Q9UI15	TAGL3_HUMAN	transgelin 3	4					central nervous system development|muscle organ development					endometrium(2)|lung(5)|urinary_tract(1)	8						ATGGCTAACAGGGGCCCGAGC	0.582													36	38	---	---	---	---					
MME	4311	broad.mit.edu	37	3	154861327	154861327	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr3:154861327delG	ENST00000460393.1	+	13	1404	c.1284delG	c.(1282-1284)gtfs	p.V428fs	MME_ENST00000493237.1_Frame_Shift_Del_p.V428fs|MME_ENST00000360490.2_Frame_Shift_Del_p.V428fs|MME_ENST00000462745.1_Frame_Shift_Del_p.V428fs|MME_ENST00000492661.1_Frame_Shift_Del_p.V428fs	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	428					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GGCTTTATGTGGAAGCAGCAT	0.423													50	160	---	---	---	---					
PGM2	55276	broad.mit.edu	37	4	37848585	37848585	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:37848585delG	ENST00000381967.4	+	9	1141	c.1041delG	c.(1039-1041)ttfs	p.L347fs	PGM2_ENST00000544359.1_Frame_Shift_Del_p.L208fs|PGM2_ENST00000537241.1_Frame_Shift_Del_p.L187fs	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	347					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						GCAATGAGTTGGGGGCCCTCC	0.453													41	118	---	---	---	---					
SLC30A9	10463	broad.mit.edu	37	4	42072566	42072566	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr4:42072566delG	ENST00000264451.6	+	15	1456	c.1276delG	c.(1276-1278)gtfs	p.G426fs		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	426					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TGACAGCCTAGGTTCTTTGGG	0.408													59	128	---	---	---	---					
PCDHA10	56139	broad.mit.edu	37	5	140237982	140237982	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:140237982delC	ENST00000307360.5	+	1	2349	c.2349delC	c.(2347-2349)gafs	p.D783fs	PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA9_ENST00000532602.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGATGTGGACGGGGAAGATC	0.522													11	17	---	---	---	---					
NSD1	64324	broad.mit.edu	37	5	176700778	176700779	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr5:176700778_176700779delAT	ENST00000439151.2	+	17	5660_5661	c.5615_5616delAT	c.(5614-5616)cfs	p.H1872fs	NSD1_ENST00000347982.4_Frame_Shift_Del_p.H1603fs|NSD1_ENST00000361032.4_Frame_Shift_Del_p.H1769fs|NSD1_ENST00000354179.4_Frame_Shift_Del_p.H1603fs	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1872					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCTTATAAACATATAAAGGTGA	0.450			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			40	15	---	---	---	---					
ZNF318	24149	broad.mit.edu	37	6	43306452	43306471	+	Frame_Shift_Del	DEL	GGCTTTCCTTATCCTGGTTA	GGCTTTCCTTATCCTGGTTA	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:43306452_43306471delGGCTTTCCTTATCCTGGTTA	ENST00000361428.2	-	10	5342_5361	c.5265_5284delTAACCAGGATAAGGAAAGCC	c.(5263-5286)gtaafs	p.VNQDKESQ1755fs	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1755					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CGGAGCTCTTGGCTTTCCTTATCCTGGTTAACAGATTCTC	0.436													12	81	---	---	---	---					
LPAL2	80350	broad.mit.edu	37	6	160908670	160908671	+	RNA	INS	-	-	T	rs149149185	by1000genomes	TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr6:160908670_160908671insT	ENST00000335388.5	-	0	508					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GATTTTAACTGTTTTTTTTTTA	0.356													4	2	---	---	---	---					
AC073842.19	0	broad.mit.edu	37	7	99737172	99737172	+	RNA	DEL	T	T	-	rs56301545		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr7:99737172delT	ENST00000376482.3	+	0	74																											gcgcATGGACTTTTTTTTTTT	0.423													3	2	---	---	---	---					
ADAM18	8749	broad.mit.edu	37	8	39521390	39521391	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr8:39521390_39521391insT	ENST00000265707.5	+	13	1352_1353	c.1307_1308insT	c.(1306-1308)ttgfs	p.L436fs	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Frame_Shift_Ins_p.L412fs	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	436	Disintegrin.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TCTGGACCATGTTGTACATCAA	0.322													15	38	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139402413	139402413	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr9:139402413delG	ENST00000277541.6	-	21	3579	c.3504delC	c.(3502-3504)tcfs	p.S1168fs		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1168	EGF-like 30.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCACCTTGCAGGAGTAGCCGC	0.652			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			25	40	---	---	---	---					
ST8SIA6	338596	broad.mit.edu	37	10	17373447	17373448	+	Frame_Shift_Ins	INS	-	-	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:17373447_17373448insC	ENST00000377602.4	-	5	555_556	c.481_482insG	c.(481-483)aatfs	p.N161fs		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	161					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						AATTGGGATTTCTTTTTTGCTT	0.366													32	87	---	---	---	---					
ATRNL1	26033	broad.mit.edu	37	10	116887418	116887418	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr10:116887418delG	ENST00000355044.3	+	4	679	c.553delG	c.(553-555)gcfs	p.G185fs	ATRNL1_ENST00000527407.1_Frame_Shift_Del_p.G185fs|ATRNL1_ENST00000529665.1_3'UTR	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	185	CUB.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TACTACATCTGGCTATGCACT	0.313													20	49	---	---	---	---					
KLRAP1	10748	broad.mit.edu	37	12	10750542	10750542	+	RNA	DEL	C	C	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:10750542delC	ENST00000510134.2	-	0	315																				breast(1)|large_intestine(1)|lung(1)	3						TTTCTTATCACCAGCCAAGAA	0.318													16	29	---	---	---	---					
LST3	0	broad.mit.edu	37	12	21205160	21205160	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr12:21205160delG	ENST00000381541.3	+	10	1527	c.1462delG	c.(1462-1464)gafs	p.G488fs	SLCO1B7_ENST00000554957.1_Frame_Shift_Del_p.G488fs|SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000421593.2_Frame_Shift_Del_p.G441fs|LST3_ENST00000540229.1_Intron																							TTGTCTAGCAGGATGCAAATC	0.358													33	98	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25468643	25468644	+	RNA	INS	-	-	TT			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:25468643_25468644insTT	ENST00000453082.2	+	0	885					NR_003343.1																						TGGGCTTGGTGTTTGCGCTCCT	0.614													15	9	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25490791	25490791	+	RNA	DEL	C	C	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:25490791delC	ENST00000453082.2	+	0	2719					NR_003343.1																						GACCTGGAGGCCCTGAAGGGC	0.582													64	43	---	---	---	---					
DNM1P46	196968	broad.mit.edu	37	15	100331893	100331894	+	RNA	INS	-	-	C			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr15:100331893_100331894insC	ENST00000341853.1	-	0	2297_2298					NR_003260.1																						TCCTCTGTGGTCCCTCCAAGAC	0.584													15	24	---	---	---	---					
SMG1P3	100271836	broad.mit.edu	37	16	21469994	21469994	+	RNA	DEL	A	A	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:21469994delA	ENST00000520823.2	-	0	749																											ACTGTACATTAAAAAAAAAAA	0.294													2	4	---	---	---	---					
RRN3P2	653390	broad.mit.edu	37	16	29113498	29113498	+	RNA	DEL	T	T	-	rs11366120		TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr16:29113498delT	ENST00000564580.1	+	0	1360																											AGGAGGTGGAttttttttttc	0.542													8	8	---	---	---	---					
SCAF1	58506	broad.mit.edu	37	19	50155567	50155569	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr19:50155567_50155569delAAG	ENST00000360565.3	+	7	2045_2047	c.1921_1923delAAG	c.(1921-1923)del	p.K645del		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	645	Arg-rich.|Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TGGCGGCAGCAAGAAGAAGAAGA	0.744													2	4	---	---	---	---					
KIAA1755	85449	broad.mit.edu	37	20	36851953	36851953	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr20:36851953delG	ENST00000279024.4	-	9	2526	c.2255delC	c.(2254-2256)ctfs	p.P752fs		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	752										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CATCCCCCCAGGGGGGTCGGC	0.617													17	30	---	---	---	---					
CLTCL1	8218	broad.mit.edu	37	22	19184057	19184057	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:19184057delC	ENST00000263200.10	-	25	4056	c.3984delG	c.(3982-3984)aafs	p.K1328fs	CLTCL1_ENST00000353891.5_Frame_Shift_Del_p.K1328fs|CLTCL1_ENST00000442042.2_5'UTR|CLTCL1_ENST00000427926.1_Frame_Shift_Del_p.K1328fs	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1328	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TCTTCTGTGGCTTGAATTTGG	0.572			T	?	ALCL								11	24	---	---	---	---					
TMEM211	255349	broad.mit.edu	37	22	25331445	25331445	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:25331445delC	ENST00000407886.1	-	4	497	c.245delG	c.(244-246)gtfs	p.G82fs	TMEM211_ENST00000423535.1_Frame_Shift_Del_p.G153fs|TMEM211_ENST00000382744.1_Frame_Shift_Del_p.G82fs			Q6ICI0	TM211_HUMAN	transmembrane protein 211	153						integral to membrane				endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						AGTCATGTAACCCCAACCCAG	0.562													14	50	---	---	---	---					
EWSR1	2130	broad.mit.edu	37	22	29674145	29674146	+	Frame_Shift_Ins	INS	-	-	T			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chr22:29674145_29674146insT	ENST00000397938.2	+	5	672_673	c.353_354insT	c.(352-354)tggfs	p.W118fs	EWSR1_ENST00000406548.1_Frame_Shift_Ins_p.W118fs|EWSR1_ENST00000332035.6_Frame_Shift_Ins_p.W118fs|EWSR1_ENST00000332050.6_Frame_Shift_Ins_p.W118fs|EWSR1_ENST00000331029.7_Frame_Shift_Ins_p.W118fs|EWSR1_ENST00000333395.6_Frame_Shift_Ins_p.W118fs|EWSR1_ENST00000414183.2_Frame_Shift_Ins_p.W124fs	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	118	31 X approximate tandem repeats.|EAD (Gln/Pro/Thr-rich).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CAGTCTGCATATGGCACTCAGC	0.554			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								9	33	---	---	---	---					
ARAF	369	broad.mit.edu	37	X	47426094	47426094	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QK-A8Z8-01A-11D-A391-08	TCGA-QK-A8Z8-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4dac53b2-6d3e-4740-bd93-5248f93a0643	1e058e03-3c90-4fa7-b8d3-57358d37e736	g.chrX:47426094delC	ENST00000377045.4	+	7	808	c.614delC	c.(613-615)gcfs	p.A205fs	ARAF_ENST00000290277.6_Intron	NM_001256196.1|NM_001654.4	NP_001243125.1|NP_001645.1	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene homolog	205					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity	p.L207fs*85(1)		biliary_tract(1)|endometrium(4)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	29					Adenosine triphosphate(DB00171)	CCAGCCAATGCCCCCCTACAG	0.632													8	20	---	---	---	---					
