Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MBTPS1	8720	broad.mit.edu	37	16	84089675	84089675	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:84089675C>T	ENST00000343411.3	-	22	3392	c.2897G>A	c.(2896-2898)cGa>cAa	p.R966Q		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	966					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GCGATTCGATCGAAAGTTGGG	0.483000													30	100					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202131238	202131238	+	Missense_Mutation	SNP	T	T	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:202131238T>C	ENST00000358485.4	+	2	402	c.206T>C	c.(205-207)aTt>aCt	p.I69T	CASP8_ENST00000392266.3_Missense_Mutation_p.I10T|CASP8_ENST00000392259.2_Missense_Mutation_p.I10T|CASP8_ENST00000264274.9_Missense_Mutation_p.I10T|CASP8_ENST00000264275.5_Missense_Mutation_p.I10T|CASP8_ENST00000323492.7_Missense_Mutation_p.I10T|CASP8_ENST00000432109.2_Missense_Mutation_p.I10T|CASP8_ENST00000392258.3_Missense_Mutation_p.I10T	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	10	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding	p.I10T(2)|p.I69T(1)		breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						CTTTATGATATTGGGGAACAA	0.408000										HNSCC(4;0.00038)			40	58					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	129046276	129046276	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:129046276G>A	ENST00000325006.3	+	10	1318	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	AHCYL2_ENST00000446544.2_Missense_Mutation_p.E421K|AHCYL2_ENST00000446212.1_Missense_Mutation_p.E320K|AHCYL2_ENST00000531335.2_Missense_Mutation_p.E341K|AHCYL2_ENST00000490911.1_Missense_Mutation_p.E319K|AHCYL2_ENST00000474594.1_Missense_Mutation_p.E319K	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	422					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						GTATGTAACTGAAATTGACCC	0.522000													21	117					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547138	132547138	+	Silent	SNP	A	A	G	rs35873108	byFrequency	TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:132547138A>G	ENST00000333577.4	+	48	8443	c.8334A>G	c.(8332-8334)caA>caG	p.Q2778Q	EP400_ENST00000389562.2_Silent_p.Q2741Q|EP400_ENST00000389561.2_Silent_p.Q2742Q|EP400_ENST00000332482.4_Silent_p.Q2705Q|EP400_ENST00000330386.6_Silent_p.Q2661Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2778	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2741Q(3)|p.Q2742Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcaacagcagcagc	0.602000													4	73					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77641807	77641807	+	Missense_Mutation	SNP	T	T	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr13:77641807T>C	ENST00000407578.2	-	71	12630	c.12364A>G	c.(12364-12366)Aaa>Gaa	p.K4122E	MYCBP2_ENST00000544440.2_Missense_Mutation_p.K4084E|MYCBP2_ENST00000357337.6_Missense_Mutation_p.K4084E	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4084					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCTTTGGCTTTTAGCTGTACA	0.433000													58	259					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28599144	28599144	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:28599144C>T	ENST00000253063.3	+	5	911	c.590C>T	c.(589-591)gCt>gTt	p.A197V		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	197					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		CTCATTCAGGCTCTGGTCCTG	0.652000													25	102					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119568502	119568502	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:119568502G>A	ENST00000267260.4	+	8	1022	c.634G>A	c.(634-636)Gag>Aag	p.E212K	SRRM4_ENST00000537597.1_3'UTR	NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	212	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CCGGTCCCCTGAGGAAGGGCA	0.647000													11	16					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50683801	50683801	+	Missense_Mutation	SNP	G	G	A	rs138053380		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr18:50683801G>A	ENST00000442544.2	+	8	1953	c.1337G>A	c.(1336-1338)cGt>cAt	p.R446H	DCC_ENST00000412726.1_Missense_Mutation_p.R294H|DCC_ENST00000581580.1_Missense_Mutation_p.R101H	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	446	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.R446H(3)		NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CGATTTGTCCGTCTCAGCTGG	0.517000													26	124					0	0	1	0	0
ALG12	79087	broad.mit.edu	37	22	50302947	50302947	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:50302947G>C	ENST00000330817.5	-	6	986	c.713C>G	c.(712-714)cCg>cGg	p.P238R		NM_024105.3	NP_077010.1	Q9BV10	ALG12_HUMAN	ALG12, alpha-1,6-mannosyltransferase	238					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane		p.P238L(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(3)	12		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		CTTTCCTTCCGGCCAAGTGAG	0.502000													18	79					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75101306	75101306	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:75101306G>C	ENST00000310715.3	-	7	763	c.643C>G	c.(643-645)Ctg>Gtg	p.L215V	TTC18_ENST00000394865.1_Missense_Mutation_p.L215V|TTC18_ENST00000340329.3_Missense_Mutation_p.L215V|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000401621.2_Missense_Mutation_p.L215V	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	215							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CCAAGCTTCAGAGTTCCATTC	0.403000													40	155					0	0	1	0	0
FAM110C	642273	broad.mit.edu	37	2	45619	45619	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:45619G>A	ENST00000327669.4	-	1	766	c.767C>T	c.(766-768)tCc>tTc	p.S256F		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	256						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		GCCGCTGCCGGAGGTGGCGAC	0.697000													10	28					0	0	1	0	0
ZSWIM1	90204	broad.mit.edu	37	20	44511955	44511955	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr20:44511955G>A	ENST00000372523.1	+	2	819	c.724G>A	c.(724-726)Gct>Act	p.A242T	ZSWIM1_ENST00000372520.1_Missense_Mutation_p.A242T	NM_080603.4	NP_542170.3	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	242							zinc ion binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13		Myeloproliferative disorder(115;0.028)				CATCTGGCTGGCTCACCGCTG	0.577000													4	62					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49216159	49216159	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:49216159C>T	ENST00000406846.2	-	6	600	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	FSHR_ENST00000346173.3_Missense_Mutation_p.E161K|FSHR_ENST00000541117.1_5'UTR|FSHR_ENST00000469138.1_5'UTR|FSHR_ENST00000304421.4_Intron	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	161					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GAATTTCTTTCAATTGTGTGG	0.333000									Gonadal Dysgenesis, 46 XX				9	44					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38942235	38942235	+	Missense_Mutation	SNP	T	T	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:38942235T>C	ENST00000359357.3	+	83	12367	c.12113T>C	c.(12112-12114)cTg>cCg	p.L4038P	DNAH8_ENST00000441566.1_Missense_Mutation_p.L4002P					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CAAGACCTTCTGGACATCAGT	0.418000													31	104					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21098748	21098748	+	Silent	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:21098748G>C	ENST00000377122.4	-	25	2994	c.2598C>G	c.(2596-2598)ctC>ctG	p.L866L	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	866	Linker.				regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AGAGCATATGGAGACTTCTAG	0.423000													16	67					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368706	40368706	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:40368706G>A	ENST00000221347.6	-	28	12649	c.12642C>T	c.(12640-12642)tgC>tgT	p.C4214C		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4214	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGCAGAGCCCGCACACTGCGC	0.607000													6	668					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65474920	65474920	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:65474920C>T	ENST00000519389.1	+	16	2948	c.2769C>T	c.(2767-2769)ggC>ggT	p.G923G	HEPH_ENST00000336279.5_Silent_p.G602G|HEPH_ENST00000419594.1_Silent_p.G680G|HEPH_ENST00000374727.3_Silent_p.G872G|HEPH_ENST00000343002.2_Silent_p.G869G|HEPH_ENST00000441993.2_Silent_p.G872G			Q9BQS7	HEPH_HUMAN	hephaestin	869	Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						AGAGGTCTGGCCCTGGGCCCA	0.493000													22	68					0	0	1	0	0
ZNF394	84124	broad.mit.edu	37	7	99097278	99097278	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:99097278C>T	ENST00000337673.6	-	1	642	c.439G>A	c.(439-441)Gat>Aat	p.D147N	ZNF394_ENST00000394177.3_5'UTR|ZNF394_ENST00000426306.2_Missense_Mutation_p.D147N|ZNF789_ENST00000493485.1_Intron|ZNF789_ENST00000494186.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	147					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GAGGTTCCATCGAGCGCTCGC	0.622000													26	137					0	0	1	0	0
TMEM241	85019	broad.mit.edu	37	18	20964956	20964956	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr18:20964956C>G	ENST00000383233.3	-	5	407	c.355G>C	c.(355-357)Gag>Cag	p.E119Q	TMEM241_ENST00000399707.1_Missense_Mutation_p.E93Q|TMEM241_ENST00000542162.1_Missense_Mutation_p.E119Q|TMEM241_ENST00000450466.2_5'UTR	NM_032933.4	NP_116322.3	Q24JQ0	CR045_HUMAN	transmembrane protein 241	119						integral to membrane											TCGTTTACCTCTTTCTGAAAA	0.368000													18	66					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99359861	99359861	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:99359861C>G	ENST00000354593.2	-	6	709	c.606G>C	c.(604-606)caG>caC	p.Q202H	CYP3A4_ENST00000336411.2_Missense_Mutation_p.Q352H			P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	352					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	GATACTCCATCTGTAGCACAG	0.398000													20	66					0	0	1	0	0
ITGA2B	3674	broad.mit.edu	37	17	42452084	42452084	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:42452084G>C	ENST00000262407.5	-	28	2917	c.2886C>G	c.(2884-2886)aaC>aaG	p.N962K	ITGA2B_ENST00000353281.4_Intron	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	962					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGAGGACACGTTGAACCATG	0.617000													15	52					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167077760	167077760	+	Silent	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:167077760C>A	ENST00000392766.2	-	8	670	c.330G>T	c.(328-330)gtG>gtT	p.V110V	ZBBX_ENST00000455345.2_Silent_p.V110V|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392767.2_Silent_p.V110V|ZBBX_ENST00000307529.5_Silent_p.V110V|ZBBX_ENST00000392764.1_Silent_p.V81V	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	110						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CTGTTGGTTTCACTGGCTCTG	0.303000													11	39					1.58986e-06	1.61953e-06	1	1	0
CWC25	54883	broad.mit.edu	37	17	36963199	36963199	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:36963199G>A	ENST00000225428.4	-	7	1018	c.721C>T	c.(721-723)Cag>Tag	p.Q241*	CWC25_ENST00000536127.1_Nonsense_Mutation_p.Q178*	NM_017748.3	NP_060218.1	Q9NXE8	CWC25_HUMAN	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	241										central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	14						AGAGGACCCTGAAGACCCTGG	0.507000													21	67					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202698923	202698923	+	Nonsense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:202698923G>T	ENST00000367265.3	-	26	5573	c.4409C>A	c.(4408-4410)tCa>tAa	p.S1470*	KDM5B_ENST00000367264.2_Nonsense_Mutation_p.S1506*	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1470					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GGATGTGTCTGAGGGCAGGGA	0.483000													56	164					2.84144e-21	3.06606e-21	1	1	0
SARDH	1757	broad.mit.edu	37	9	136578218	136578218	+	Silent	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:136578218C>G	ENST00000371872.4	-	9	1436	c.1179G>C	c.(1177-1179)ctG>ctC	p.L393L	SARDH_ENST00000422262.2_Silent_p.L225L|SARDH_ENST00000439388.1_Silent_p.L393L	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	393					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCTCCCCCATCAGGGGCTTGT	0.612000													14	19					0	0	1	0	0
POLR3GL	84265	broad.mit.edu	37	1	145457071	145457071	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:145457071C>A	ENST00000369314.1	-	7	596	c.490G>T	c.(490-492)Gag>Tag	p.E164*	POLR3GL_ENST00000369313.3_Nonsense_Mutation_p.E141*	NM_032305.1	NP_115681.1	Q9BT43	RPC7L_HUMAN	polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like	164	Glu-rich.									endometrium(2)|large_intestine(1)|lung(1)	4	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					tcatcctcctctGAAGTTACT	0.443000													5	36					0.184627	0.184627	1	1	0
ZNF511	118472	broad.mit.edu	37	10	135165854	135165854	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:135165854C>T	ENST00000368554.4	+	8	865	c.843C>T	c.(841-843)ggC>ggT	p.G281G	PRAP1_ENST00000423766.1_Silent_p.G123G|PRAP1_ENST00000433452.2_Silent_p.G122G|PRAP1_ENST00000458230.1_Silent_p.G113G|PRAP1_ENST00000463201.1_3'UTR			Q8NB15	ZN511_HUMAN	zinc finger protein 511	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	8		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		AGGACCAGGGCGAGGAGAGGC	0.652000													31	110					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123265739	123265739	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:123265739C>G	ENST00000253079.6	+	3	602	c.258C>G	c.(256-258)atC>atG	p.I86M	CCDC62_ENST00000392441.4_Missense_Mutation_p.I86M|CCDC62_ENST00000537566.1_5'UTR	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	86						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		CTGAAATAATCAGGTCACTCA	0.383000													22	86					0	0	1	0	0
KRT33A	3883	broad.mit.edu	37	17	39502764	39502764	+	Missense_Mutation	SNP	C	C	T	rs142473669		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:39502764C>T	ENST00000007735.3	-	6	1077	c.1033G>A	c.(1033-1035)Gtg>Atg	p.V345M		NM_004138.3	NP_004129.2	O76009	KT33A_HUMAN	keratin 33A	345	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	21		Breast(137;0.000496)				CGCGCCCGCACGTCCAGCAGC	0.607000													31	121					0	0	1	0	0
RHOV	171177	broad.mit.edu	37	15	41165520	41165520	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr15:41165520G>A	ENST00000220507.4	-	3	596	c.447C>T	c.(445-447)gaC>gaT	p.D149D		NM_133639.3	NP_598378.3	Q96L33	RHOV_HUMAN	ras homolog family member V	149					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding			central_nervous_system(1)|large_intestine(1)	2		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CGTTGACATCGTCCCTCAGGT	0.647000													37	114					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50795567	50795567	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:50795567G>A	ENST00000440075.2	+	37	5224	c.5177G>A	c.(5176-5178)cGg>cAg	p.R1726Q	MYH14_ENST00000262269.8_Missense_Mutation_p.R1726Q|MYH14_ENST00000425460.1_Missense_Mutation_p.R1693Q|MYH14_ENST00000376970.2_Missense_Mutation_p.R1718Q|MYH14_ENST00000598205.1_Missense_Mutation_p.R1693Q|MYH14_ENST00000601313.1_Missense_Mutation_p.R1726Q|MYH14_ENST00000596571.1_Missense_Mutation_p.R1685Q			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1685					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CGCACCTCCCGGGAGGAGATC	0.632000													3	7					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206608073	206608073	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:206608073C>T	ENST00000360409.3	+	9	2229	c.1438C>T	c.(1438-1440)Cag>Tag	p.Q480*	NRP2_ENST00000540841.1_Nonsense_Mutation_p.Q480*|NRP2_ENST00000272849.3_Nonsense_Mutation_p.Q480*|NRP2_ENST00000417189.1_Nonsense_Mutation_p.Q480*|NRP2_ENST00000357785.5_Nonsense_Mutation_p.Q480*|NRP2_ENST00000412873.2_Nonsense_Mutation_p.Q480*|NRP2_ENST00000355117.4_Nonsense_Mutation_p.Q480*|NRP2_ENST00000540178.1_Nonsense_Mutation_p.Q480*|NRP2_ENST00000357118.4_Nonsense_Mutation_p.Q480*	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	480	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TCGAATCCCTCAGGCCCAGCC	0.617000													53	66					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079539	31079539	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:31079539G>A	ENST00000259870.3	-	2	600	c.597C>T	c.(595-597)ctC>ctT	p.L199L		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	199										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						CCCTGTGGATGAGAGACCAGG	0.617000													16	48					0	0	1	0	0
NLN	57486	broad.mit.edu	37	5	65118740	65118740	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr5:65118740G>A	ENST00000380985.5	+	13	2290	c.2112G>A	c.(2110-2112)ccG>ccA	p.P704P	NLN_ENST00000515595.1_3'UTR|NLN_ENST00000502464.1_Silent_p.P600P	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	704			P -> S (in dbSNP:rs6860508).		proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		TGCATGCTCCGTGAACTGGGG	0.498000													26	93					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1812538	1812538	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr8:1812538G>A	ENST00000518288.1	+	6	719	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K	ARHGEF10_ENST00000262112.6_Missense_Mutation_p.E186K|ARHGEF10_ENST00000520359.1_Missense_Mutation_p.E162K|ARHGEF10_ENST00000398560.1_Missense_Mutation_p.E186K|ARHGEF10_ENST00000349830.3_Splice_Site|ARHGEF10_ENST00000398564.1_Missense_Mutation_p.E186K			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	186					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TTTCCCAGCAGAAACACCAGA	0.448000													38	85					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145530360	145530360	+	Missense_Mutation	SNP	T	T	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:145530360T>C	ENST00000369304.3	+	6	750	c.575T>C	c.(574-576)gTa>gCa	p.V192A	ITGA10_ENST00000538811.1_Missense_Mutation_p.V61A|ITGA10_ENST00000539363.1_Missense_Mutation_p.V49A	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	192	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGAAGACTGGTAGGGAAACTG	0.488000													28	106					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994102	140994102	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:140994102G>A	ENST00000285879.4	+	4	1198	c.912G>A	c.(910-912)caG>caA	p.Q304Q	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	304							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCTCTCCAGATTCCTGTGA	0.498000										HNSCC(15;0.026)			73	403					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151749034	151749034	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:151749034C>G	ENST00000368822.1	-	7	1558	c.925G>C	c.(925-927)Gaa>Caa	p.E309Q	TDRKH_ENST00000368823.1_Missense_Mutation_p.E305Q|TDRKH_ENST00000368827.6_Missense_Mutation_p.E309Q|TDRKH_ENST00000458431.2_Missense_Mutation_p.E309Q|TDRKH_ENST00000368825.3_Missense_Mutation_p.E264Q|TDRKH_ENST00000440583.2_Missense_Mutation_p.E85Q|TDRKH_ENST00000368824.3_Missense_Mutation_p.E309Q			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	309							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACGTAGACTTCTAGGTACTCA	0.493000													33	79					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35831832	35831832	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:35831832G>C	ENST00000085219.5	+	7	1364	c.1298G>C	c.(1297-1299)cGa>cCa	p.R433P	CD22_ENST00000270311.6_Missense_Mutation_p.R313P|CD22_ENST00000419549.2_Missense_Mutation_p.R261P|CD22_ENST00000544992.2_Missense_Mutation_p.R433P|CD22_ENST00000341773.6_Missense_Mutation_p.R256P|CD22_ENST00000594250.1_Missense_Mutation_p.R256P|CD22_ENST00000536635.2_Missense_Mutation_p.R345P	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	433	Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	ATGCCGATTCGAGAAGGAGAC	0.512000													26	96					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18851040	18851040	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:18851040C>G	ENST00000446231.2	-	42	7337	c.6925G>C	c.(6925-6927)Gaa>Caa	p.E2309Q	SMG1_ENST00000389467.3_Missense_Mutation_p.E2309Q			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2309	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CTCCACCATTCATCAGGTGTT	0.453000													27	91					0	0	1	0	0
TRIP10	9322	broad.mit.edu	37	19	6742999	6742999	+	Silent	SNP	C	C	T	rs148560112	byFrequency	TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:6742999C>T	ENST00000313244.9	+	4	254	c.219C>T	c.(217-219)ttC>ttT	p.F73F	TRIP10_ENST00000596758.1_Silent_p.F73F|TRIP10_ENST00000596543.1_3'UTR|TRIP10_ENST00000313285.8_Silent_p.F73F|TRIP10_ENST00000600428.1_5'UTR			Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	73	Induction of membrane tubulation.|Required for podosome formation and interaction with AKAP9 and microtubules.|Required for translocation to the plasma membrane in response to insulin (By similarity).				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding	p.F73F(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	16						AACAGTCCTTCGTACAGATTC	0.582000													23	82					0	0	1	0	0
HIST1H2BN	8341	broad.mit.edu	37	6	27806511	27806511	+	Missense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:27806511G>T	ENST00000606613.1	+	1	133	c.72G>T	c.(70-72)aaG>aaT	p.K24N	HIST1H2BN_ENST00000396980.3_Missense_Mutation_p.K24N			Q99877	H2B1N_HUMAN	histone cluster 1, H2bn	24					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(3)|lung(3)|prostate(1)	8						AGGCCCAGAAGAAGGACGGCA	0.587000													51	208					2.0833e-19	2.23914e-19	1	1	0
ACP2	53	broad.mit.edu	37	11	47269208	47269208	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:47269208G>C	ENST00000256997.3	-	3	397	c.281C>G	c.(280-282)tCt>tGt	p.S94C	ACP2_ENST00000527256.1_Missense_Mutation_p.S62C|ACP2_ENST00000444355.2_Missense_Mutation_p.S94C|ACP2_ENST00000537863.1_5'UTR|ACP2_ENST00000533929.1_Missense_Mutation_p.S66C|ACP2_ENST00000529444.1_Missense_Mutation_p.S94C|ACP2_ENST00000529788.1_Missense_Mutation_p.S94C|ACP2_ENST00000530453.1_Missense_Mutation_p.S94C	NM_001610.2	NP_001601.1	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal	94						integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)	10						CCGGTGATAAGAGGTGTTTAG	0.592000													35	96					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108427467	108427467	+	Missense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:108427467C>A	ENST00000263054.6	-	17	2290	c.2283G>T	c.(2281-2283)caG>caT	p.Q761H	SORCS1_ENST00000369698.1_Missense_Mutation_p.Q296H|SORCS1_ENST00000344440.6_Missense_Mutation_p.Q761H	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	761						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGAGGTAACTCTGTCCCAAGC	0.483000													5	24					0.000602214	0.000611169	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1268340	1268340	+	Silent	SNP	A	A	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:1268340A>T	ENST00000447027.1	+	31	10297	c.10239A>T	c.(10237-10239)ccA>ccT	p.P3413P	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Silent_p.P3410P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3410	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		cctcaactccagggacaactc	0.637000													3	13					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71302194	71302194	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr15:71302194G>A	ENST00000260382.5	+	13	1716	c.1456G>A	c.(1456-1458)Gca>Aca	p.A486T	LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000544974.2_Missense_Mutation_p.A476T|LRRC49_ENST00000560691.1_Missense_Mutation_p.A192T|LRRC49_ENST00000560158.2_Missense_Mutation_p.A174T|LRRC49_ENST00000443425.2_Missense_Mutation_p.A442T|LRRC49_ENST00000560369.1_Missense_Mutation_p.A491T	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	486						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						GCAATTTAACGCACTAGCCCA	0.363000													34	90					0	0	1	0	0
GZF1	64412	broad.mit.edu	37	20	23345286	23345286	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr20:23345286C>T	ENST00000338121.5	+	2	343	c.266C>T	c.(265-267)tCa>tTa	p.S89L	GZF1_ENST00000377051.2_Missense_Mutation_p.S89L|GZF1_ENST00000544236.1_Intron|GZF1_ENST00000542987.1_Intron			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	89	BTB.				transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					GACTTTGCTTCATTTCTTGAG	0.413000													23	58					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23904625	23904625	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr13:23904625C>T	ENST00000382298.3	-	10	13978	c.13390G>A	c.(13390-13392)Gac>Aac	p.D4464N	SACS_ENST00000402364.1_Missense_Mutation_p.D3714N|SACS_ENST00000382292.3_Missense_Mutation_p.D4464N	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4464	HEPN.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTATGAAGGTCATTCCTGGCA	0.458000													45	191					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89350234	89350234	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:89350234G>A	ENST00000301030.4	-	9	3176	c.2716C>T	c.(2716-2718)Cga>Tga	p.R906*	ANKRD11_ENST00000378330.2_Nonsense_Mutation_p.R906*	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	906	Lys-rich.					nucleus		p.R906R(1)		breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCCTTCTTTCGGAAGAAGGGC	0.527000													25	60					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100283874	100283874	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:100283874C>G	ENST00000275732.5	-	8	2086	c.877G>C	c.(877-879)Gag>Cag	p.E293Q	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	293										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					AGGCACCACTCTGGGAGCCCA	0.627000													20	52					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198949559	198949559	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:198949559C>T	ENST00000428675.1	+	2	1716	c.1318C>T	c.(1318-1320)Cga>Tga	p.R440*	PLCL1_ENST00000437704.2_Nonsense_Mutation_p.R342*	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	440	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	AATGGGCTGTCGAAGCGTTGA	0.408000													16	76					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238303539	238303539	+	Missense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:238303539C>A	ENST00000295550.4	-	3	852	c.400G>T	c.(400-402)Gct>Tct	p.A134S	COL6A3_ENST00000353578.4_Intron|COL6A3_ENST00000347401.3_Missense_Mutation_p.A134S|COL6A3_ENST00000346358.4_Missense_Mutation_p.A134S|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000392004.3_Intron|COL6A3_ENST00000409809.1_Intron|COL6A3_ENST00000392003.2_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	134	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGGCTTCCAGCAGCCTTGGTG	0.488000													79	83					2.32478e-39	2.57994e-39	1	1	0
TNK1	8711	broad.mit.edu	37	17	7286862	7286862	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:7286862G>C	ENST00000570896.1	+	5	799	c.353G>C	c.(352-354)aGa>aCa	p.R118T	TNK1_ENST00000576812.1_Missense_Mutation_p.R118T|TNK1_ENST00000311668.2_Missense_Mutation_p.R118T			Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	118	Protein kinase.			R -> K (in Ref. 2; AAC99412).	protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				GCTGTTTGCAGAGGGGAGCTG	0.657000													6	31					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10602926	10602926	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:10602926C>T	ENST00000171111.5	-	3	1199	c.652G>A	c.(652-654)Gag>Aag	p.E218K	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.E218K	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	218	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.E218Q(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			AAGAACTCCTCTTGCTTGGCC	0.607000													4	45					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776059	5776059	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:5776059C>T	ENST00000317254.3	+	1	137	c.89C>T	c.(88-90)tCc>tTc	p.S30F	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CTCTGGATTTCCTTCCCATTC	0.438000													32	124					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47788783	47788783	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:47788783G>A	ENST00000273857.4	-	3	367	c.368C>T	c.(367-369)aCg>aTg	p.T123M	CORIN_ENST00000504584.1_Missense_Mutation_p.T123M|CORIN_ENST00000508498.1_De_novo_Start_InFrame|CORIN_ENST00000505909.1_Missense_Mutation_p.T123M|CORIN_ENST00000502252.1_Intron	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	123					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						AGAAGCATCCGTAGTCCAGGC	0.453000													25	74					0	0	1	0	0
SCIMP	388325	broad.mit.edu	37	17	5124583	5124583	+	Splice_Site	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:5124583C>T	ENST00000574081.1	-	3	312	c.209_splice	c.e3+1	p.E70_splice	SCIMP_ENST00000574297.1_Splice_Site_p.E70_splice|SCIMP_ENST00000399600.4_Splice_Site_p.E63_splice|RP11-333E1.1_ENST00000575601.1_RNA|SCIMP_ENST00000571800.1_Splice_Site_p.E63_splice|RP11-333E1.1_ENST00000571689.1_RNA	NM_001271842.1|NM_207103.3	NP_001258771.1|NP_996986.1	Q6UWF3	CQ087_HUMAN	SLP adaptor and CSK interacting membrane protein	70						integral to membrane											CCTACTTACTCATACATCTTT	0.458000													30	128					0	0	1	0	0
FAM49B	51571	broad.mit.edu	37	8	130867886	130867886	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr8:130867886G>A	ENST00000519824.2	-	6	682	c.409C>T	c.(409-411)Cat>Tat	p.H137Y	FAM49B_ENST00000517654.1_Missense_Mutation_p.H137Y|FAM49B_ENST00000523509.1_Missense_Mutation_p.H137Y|FAM49B_ENST00000401979.2_Missense_Mutation_p.H137Y|FAM49B_ENST00000518879.1_5'UTR|FAM49B_ENST00000519110.1_Missense_Mutation_p.H137Y|FAM49B_ENST00000519540.1_Missense_Mutation_p.H137Y|FAM49B_ENST00000522941.1_5'UTR|FAM49B_ENST00000522250.1_5'UTR|FAM49B_ENST00000522746.1_Missense_Mutation_p.H137Y	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	137										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			AGTGTGAAATGAAGAATTTCT	0.423000													42	73					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151751715	151751715	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:151751715C>T	ENST00000368822.1	-	5	1058	c.425G>A	c.(424-426)aGa>aAa	p.R142K	TDRKH_ENST00000368823.1_Missense_Mutation_p.R138K|TDRKH_ENST00000368827.6_Missense_Mutation_p.R142K|TDRKH_ENST00000484421.1_5'UTR|TDRKH_ENST00000458431.2_Missense_Mutation_p.R142K|TDRKH_ENST00000368825.3_Intron|TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000368824.3_Missense_Mutation_p.R142K			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	142	KH 2.						RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTCGCCGCCTCTCCCTACATT	0.398000													21	59					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3779766	3779766	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:3779766G>C	ENST00000262367.5	-	31	6091	c.5282C>G	c.(5281-5283)tCa>tGa	p.S1761*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.S1723*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1761	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.S1761*(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGGGCTCTTTGACTGTGGCTC	0.632000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						10	39					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114454229	114454229	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:114454229G>A	ENST00000394779.3	-	23	3963	c.3719C>T	c.(3718-3720)tCg>tTg	p.S1240L	C9orf84_ENST00000394777.4_Missense_Mutation_p.S1205L|C9orf84_ENST00000318737.4_Missense_Mutation_p.S1279L|C9orf84_ENST00000374287.3_Missense_Mutation_p.S1279L	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	1279										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GATAGGGTCCGATACATCTTT	0.378000													22	113					0	0	1	0	0
IGLV5-45	28781	broad.mit.edu	37	22	22730636	22730636	+	RNA	SNP	G	G	A	rs149965450	by1000genomes	TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:22730636G>A	ENST00000390296.2	+	0	159																											TGCACCTTGCGCAGTGGCATC	0.537000													11	162					0	0	1	0	0
ZNF558	148156	broad.mit.edu	37	19	8923829	8923829	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:8923829C>T	ENST00000601372.1	-	8	1028	c.317G>A	c.(316-318)aGa>aAa	p.R106K	ZNF558_ENST00000444186.2_Missense_Mutation_p.R35K|ZNF558_ENST00000301475.1_Missense_Mutation_p.R106K			Q96NG5	ZN558_HUMAN	zinc finger protein 558	106	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						TAGAATTCCTCTTTCCTCTGT	0.463000													6	10					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	52026641	52026641	+	Silent	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr13:52026641C>A	ENST00000311234.4	-	1	493	c.21G>T	c.(19-21)ctG>ctT	p.L7L	INTS6_ENST00000425000.1_5'UTR|INTS6_ENST00000442263.3_Silent_p.L7L|INTS6_ENST00000491723.1_5'UTR|INTS6_ENST00000398119.2_Intron|INTS6_ENST00000463928.1_Silent_p.L7L|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000594959.1_RNA|INTS6_ENST00000420668.2_Silent_p.L7L	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	7	VWFA.				snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		ACGTGTCTATCAGGAACAGTA	0.622000													17	86					2.94398e-08	3.03286e-08	1	1	0
WNT7A	7476	broad.mit.edu	37	3	13860852	13860852	+	Silent	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:13860852C>G	ENST00000285018.4	-	4	943	c.639G>C	c.(637-639)acG>acC	p.T213T		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	213					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						TGGTCCAGCACGTCTTGGTGG	0.607000													18	96					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7562886	7562886	+	Splice_Site	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:7562886C>T	ENST00000379802.3	+	5	940	c.597_splice	c.e5-1	p.A200_splice	DSP_ENST00000418664.2_Splice_Site_p.A200_splice	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	200	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GTGTCGCAGGCGGAGATGGAC	0.557000													46	164					0	0	1	0	0
C7orf49	78996	broad.mit.edu	37	7	134853635	134853635	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:134853635G>A	ENST00000393114.3	-	2	221	c.40C>T	c.(40-42)Ccc>Tcc	p.P14S	C7orf49_ENST00000459937.1_5'UTR|C7orf49_ENST00000424142.1_5'UTR|C7orf49_ENST00000430372.1_5'UTR|C7orf49_ENST00000483029.2_Intron			Q9BWK5	MRI_HUMAN	chromosome 7 open reading frame 49	14						cytoplasm				endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						AGCCATGAGGGAAGGACCCTC	0.502000											OREG0018340	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	106					0	0	1	0	0
CA5A	763	broad.mit.edu	37	16	87960549	87960549	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:87960549G>A	ENST00000309893.2	-	2	210	c.145C>T	c.(145-147)Cac>Tac	p.H49Y	CA5A_ENST00000568801.1_5'UTR	NM_001739.1	NP_001730.1	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial	49					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding			large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(80;0.0513)		CAGAGTGGGTGCACTGCAGGG	0.632000													4	12					0	0	1	0	0
RABGAP1	23637	broad.mit.edu	37	9	125751664	125751664	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:125751664G>C	ENST00000373647.4	+	5	813	c.679G>C	c.(679-681)Gag>Cag	p.E227Q		NM_012197.3	NP_036329.3	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	227	PID.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|prostate(4)|stomach(3)|upper_aerodigestive_tract(1)	41						TGGAACTCCTGAGAGTGACTG	0.418000													37	150					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62291749	62291749	+	Silent	SNP	T	T	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:62291749T>A	ENST00000378024.4	-	5	10414	c.10140A>T	c.(10138-10140)atA>atT	p.I3380I	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3380					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTGGACCTGTTATGTCAATAT	0.378000													30	119					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	41					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	145095469	145095469	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:145095469C>T	ENST00000367545.3	+	59	8601	c.8601C>T	c.(8599-8601)atC>atT	p.I2867I	UTRN_ENST00000367526.4_Silent_p.I422I	NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2867	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GTACAGCAATCAAAATCCGAA	0.308000													16	53					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151246980	151246980	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:151246980C>G	ENST00000535741.1	-	49	7906	c.7433G>C	c.(7432-7434)aGa>aCa	p.R2478T	LRBA_ENST00000357115.3_Missense_Mutation_p.R2489T|LRBA_ENST00000507224.1_Missense_Mutation_p.R2478T|LRBA_ENST00000510413.1_Missense_Mutation_p.R2478T|LRBA_ENST00000503716.1_5'UTR			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2489	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					GGCAGAACCTCTGGGAGGATG	0.458000													6	35					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68598390	68598390	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:68598390C>T	ENST00000570495.1	+	5	1992	c.1700C>T	c.(1699-1701)tCt>tTt	p.S567F	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.S567F|ZFP90_ENST00000563169.2_Missense_Mutation_p.S567F			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	567					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CAAAGTTCATCTCTCATTCAG	0.433000													53	145					0	0	1	0	0
RRS1	23212	broad.mit.edu	37	8	67341423	67341423	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr8:67341423G>C	ENST00000320270.2	+	1	161	c.57G>C	c.(55-57)gaG>gaC	p.E19D		NM_015169.3	NP_055984.1	Q15050	RRS1_HUMAN	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	19					mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus				kidney(2)|lung(2)	4		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			ACGAGGCAGAGAAGTTGCAAC	0.652000											OREG0018806	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	47					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21349277	21349277	+	Missense_Mutation	SNP	C	C	T	rs148677674	by1000genomes	TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:21349277C>T	ENST00000215739.8	+	16	2263	c.1904C>T	c.(1903-1905)cCg>cTg	p.P635L	LZTR1_ENST00000389355.3_Missense_Mutation_p.P616L|LZTR1_ENST00000479606.1_3'UTR	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	635					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AAGCAGCAGCCGCCCCCTCGC	0.607000													26	80					0	0	1	0	0
TNK1	8711	broad.mit.edu	37	17	7286819	7286819	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:7286819G>C	ENST00000570896.1	+	5	756	c.310G>C	c.(310-312)Gag>Cag	p.E104Q	TNK1_ENST00000576812.1_Missense_Mutation_p.E104Q|TNK1_ENST00000311668.2_Missense_Mutation_p.E104Q			Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	104					protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				CCCTGAGCCAGAGGGGGGCCT	0.632000													7	22					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32849050	32849050	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr13:32849050C>T	ENST00000380250.3	+	56	8704	c.8208C>T	c.(8206-8208)atC>atT	p.I2736I	FRY_ENST00000542859.1_Silent_p.I106I	NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2736					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCCGGGGAATCGGATCCAAAT	0.468000													37	114					0	0	1	0	0
DUSP18	150290	broad.mit.edu	37	22	31059759	31059759	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:31059759G>A	ENST00000334679.3	-	2	737	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C	DUSP18_ENST00000461301.1_Intron|DUSP18_ENST00000403268.1_Intron|DUSP18_ENST00000407308.1_Missense_Mutation_p.R78C|DUSP18_ENST00000404885.1_Missense_Mutation_p.R78C	NM_152511.3	NP_689724.3	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	78						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)|prostate(1)|skin(1)	4						TCACAGAGACGTGAGTTAGGG	0.522000													28	102					0	0	1	0	0
ACOT6	641372	broad.mit.edu	37	14	74086219	74086219	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr14:74086219G>A	ENST00000381139.1	+	2	631	c.300G>A	c.(298-300)gcG>gcA	p.A100A	RP3-414A15.10_ENST00000555011.1_RNA	NM_001037162.1	NP_001032239.1	Q3I5F7	ACOT6_HUMAN	acyl-CoA thioesterase 6	100						cytosol	carboxylesterase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00331)		TGGAAAAGGCGCAGGTGCCCT	0.428000													4	141					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38061414	38061414	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr14:38061414G>A	ENST00000250448.2	-	2	636	c.575C>T	c.(574-576)aCg>aTg	p.T192M	FOXA1_ENST00000540786.1_Missense_Mutation_p.T159M|FOXA1_ENST00000545425.2_5'UTR	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	192					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CTCGCTCAGCGTGAGCATCTT	0.597000													6	147					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	534285	534285	+	Missense_Mutation	SNP	C	C	A	rs104894226		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:534285C>A	ENST00000417302.1	-	2	225	c.38G>T	c.(37-39)gGt>gTt	p.G13V	HRAS_ENST00000451590.1_Missense_Mutation_p.G13V|HRAS_ENST00000397594.1_Missense_Mutation_p.G13V|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000311189.7_Missense_Mutation_p.G13V|HRAS_ENST00000397596.2_Missense_Mutation_p.G13V	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	13			G -> C (in FCSS).|G -> D (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13V(14)|p.G13D(10)|p.G12_G13insAG(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CTTGCCCACACCGCCGGCGCC	0.642000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			26	53					2.41591e-17	2.58645e-17	1	1	0
ADD2	119	broad.mit.edu	37	2	70917937	70917937	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:70917937C>T	ENST00000264436.3	-	8	1274	c.830G>A	c.(829-831)tGc>tAc	p.C277Y	ADD2_ENST00000413157.2_Missense_Mutation_p.C277Y|ADD2_ENST00000407644.2_Missense_Mutation_p.C277Y|ADD2_ENST00000430656.1_Missense_Mutation_p.C293Y|ADD2_ENST00000355733.3_Missense_Mutation_p.C277Y|AC007395.3_ENST00000457851.1_RNA	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	277					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						GGGTCCAAGGCACTTCTGCAG	0.498000													4	73					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71417890	71417890	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:71417890G>C	ENST00000302628.4	+	7	572	c.495G>C	c.(493-495)ttG>ttC	p.L165F	CALB2_ENST00000349553.5_Missense_Mutation_p.L165F	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	165	EF-hand 4.						calcium ion binding	p.L165L(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				TGTTTGACTTGAACGGGGATG	0.532000													32	116					0	0	1	0	0
RSRC2	65117	broad.mit.edu	37	12	122990163	122990163	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:122990163G>C	ENST00000331738.7	-	10	1361	c.1216C>G	c.(1216-1218)Cag>Gag	p.Q406E	RSRC2_ENST00000392442.2_5'UTR|RSRC2_ENST00000354654.2_Missense_Mutation_p.Q358E	NM_023012.5	NP_075388.2	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	406								p.Q406*(2)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		ATTTCATACTGAGCATCTAAA	0.393000													36	100					0	0	1	0	0
ENPP7	339221	broad.mit.edu	37	17	77709258	77709258	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:77709258C>T	ENST00000328313.5	+	3	1037	c.816C>T	c.(814-816)gaC>gaT	p.D272D		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	272					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCTTCCGGGACATCGAGTTTG	0.572000													32	95					0	0	1	0	0
HENMT1	113802	broad.mit.edu	37	1	109191450	109191450	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:109191450G>C	ENST00000370032.5	-	8	1340	c.920C>G	c.(919-921)tCa>tGa	p.S307*	HENMT1_ENST00000370031.1_Nonsense_Mutation_p.S338*|HENMT1_ENST00000402983.1_Nonsense_Mutation_p.S307*	NM_144584.2	NP_653185.2	Q5T8I9	HENMT_HUMAN	HEN1 methyltransferase homolog 1 (Arabidopsis)	307					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity	p.G306_P310delGSKAP(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	16						AGGGGCCTTTGAGCCACCAAT	0.517000													21	73					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882732	228882732	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:228882732C>T	ENST00000392056.3	-	7	2884	c.2838G>A	c.(2836-2838)gcG>gcA	p.A946A	SPHKAP_ENST00000344657.5_Silent_p.A946A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	946	PKA-RII subunit binding domain (By similarity).					cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAAGGCAAATCGCTGCAATTT	0.473000													4	164					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161163759	161163759	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:161163759C>T	ENST00000367996.4	-	5	1942	c.1514G>A	c.(1513-1515)cGc>cAc	p.R505H		NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	505	Disintegrin.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTGGAGGCAGCGACCACCCAT	0.652000													10	57					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878259	150878259	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:150878259C>T	ENST00000422024.1	-	3	1131	c.1006G>A	c.(1006-1008)Gac>Aac	p.D336N	ASB10_ENST00000275838.1_Missense_Mutation_p.D291N|ASB10_ENST00000434669.1_Missense_Mutation_p.D336N|ASB10_ENST00000377867.3_Missense_Mutation_p.D276N|ASB10_ENST00000420175.2_Missense_Mutation_p.D291N	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	291					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTGTCCTGGTCCGCAGCATCA	0.667000													8	39					0	0	1	0	0
ARCN1	372	broad.mit.edu	37	11	118461072	118461072	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:118461072G>A	ENST00000359415.4	+	7	1123	c.958G>A	c.(958-960)Gaa>Aaa	p.E320K	ARCN1_ENST00000534182.2_Intron|ARCN1_ENST00000392859.3_Missense_Mutation_p.E191K|ARCN1_ENST00000264028.4_Missense_Mutation_p.E279K			P48444	COPD_HUMAN	archain 1	279	MHD.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol				endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|urinary_tract(1)	13	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TATGAAGATTGAAGAAAAGAT	0.428000													17	58					0	0	1	0	0
ZNF692	55657	broad.mit.edu	37	1	249152243	249152243	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:249152243G>A	ENST00000391820.3	-	3	367	c.201C>T	c.(199-201)ttC>ttT	p.F67F	ZNF692_ENST00000427146.1_Intron|ZNF692_ENST00000366469.5_Intron|ZNF692_ENST00000451251.1_Intron|ZNF692_ENST00000306601.4_Intron|ZNF692_ENST00000366471.3_Intron			Q9BU19	ZN692_HUMAN	zinc finger protein 692	60					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CCTGAGGGTGGAAAAGAGCAG	0.627000													4	9					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120611884	120611884	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:120611884G>A	ENST00000300648.6	-	13	1195	c.1183C>T	c.(1183-1185)Cag>Tag	p.Q395*		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	395					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTTCCTGCTGAAGGAACGGG	0.512000													5	25					0	0	1	0	0
TGIF1	7050	broad.mit.edu	37	18	3452158	3452158	+	Missense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr18:3452158C>A	ENST00000330513.5	+	1	484	c.181C>A	c.(181-183)Ccc>Acc	p.P61T	TGIF1_ENST00000401449.1_Intron|TGIF1_ENST00000343820.5_Intron|TGIF1_ENST00000405385.3_Intron|TGIF1_ENST00000407501.2_Intron|TGIF1_ENST00000548489.2_Intron|TGIF1_ENST00000551541.1_Intron|TGIF1_ENST00000551402.1_Intron|TGIF1_ENST00000577543.1_Intron|TGIF1_ENST00000345133.5_Intron	NM_170695.2	NP_733796.2	Q15583	TGIF1_HUMAN	TGFB-induced factor homeobox 1	61					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13	Esophageal squamous(4;0.0859)	Colorectal(8;0.0104)				GGCCTACCTTCCCCCAGCGCC	0.721000													21	63					2.89027e-11	3.02315e-11	1	1	0
TMC6	11322	broad.mit.edu	37	17	76115082	76115082	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:76115082G>C	ENST00000590602.1	-	15	2016	c.1857C>G	c.(1855-1857)atC>atG	p.I619M	TMC6_ENST00000322914.3_Missense_Mutation_p.I619M|TMC6_ENST00000392467.3_Missense_Mutation_p.I619M|TMC6_ENST00000322933.4_Missense_Mutation_p.I198M|TMC6_ENST00000592076.1_Intron|TMC6_ENST00000306591.7_Intron|TMC6_ENST00000591436.1_Missense_Mutation_p.I198M			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	619						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GCAGCAGCTTGATGATCTGCA	0.682000													3	16					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154147314	154147314	+	Missense_Mutation	SNP	T	T	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:154147314T>C	ENST00000389740.2	-	1	190	c.91A>G	c.(91-93)Acc>Gcc	p.T31A		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	31						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			ATATTCAGGGTTCCTGGCGGA	0.393000													25	101					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14705357	14705357	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:14705357G>A	ENST00000547437.1	+	5	383	c.306G>A	c.(304-306)agG>agA	p.R102R	CLEC17A_ENST00000417570.1_Silent_p.R102R|CLEC17A_ENST00000397439.2_Silent_p.R85R	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	102						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										GACCTCCAAGGGCAGGTGAGT	0.587000													6	14					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4026875	4026875	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:4026875C>T	ENST00000404826.2	+	14	2191	c.2052C>T	c.(2050-2052)caC>caT	p.H684H	SDK1_ENST00000389531.3_Silent_p.H684H	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	684	Fibronectin type-III 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCACAGCCACGCCGTGGTGC	0.458000													49	143					0	0	1	0	0
CTSO	1519	broad.mit.edu	37	4	156850844	156850844	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:156850844C>A	ENST00000433477.3	-	6	757	c.688G>T	c.(688-690)Gaa>Taa	p.E230*		NM_001334.2	NP_001325.1	P43234	CATO_HUMAN	cathepsin O	230					proteolysis	lysosome	cysteine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|prostate(1)	16	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		TTTGCCATTTCATCTTCTTGG	0.363000													24	69					3.08376e-08	3.16491e-08	1	1	0
KIF21B	23046	broad.mit.edu	37	1	200965341	200965341	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:200965341C>T	ENST00000332129.2	-	15	2576	c.2260G>A	c.(2260-2262)Gag>Aag	p.E754K	KIF21B_ENST00000360529.5_Missense_Mutation_p.E754K|KIF21B_ENST00000422435.2_Missense_Mutation_p.E754K|KIF21B_ENST00000461742.2_Missense_Mutation_p.E754K	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	754					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TTCTTCATCTCAGCCACCTCG	0.572000													51	193					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203188883	203188883	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:203188883G>C	ENST00000367229.1	-	8	858	c.824C>G	c.(823-825)tCc>tGc	p.S275C	CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000255427.3_Missense_Mutation_p.S256C|CHIT1_ENST00000535569.1_Missense_Mutation_p.S266C	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	275					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						GTCTGATGAGGAGGCCAGTGT	0.602000													21	79					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42794083	42794083	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:42794083G>A	ENST00000572681.2	+	10	4239	c.4171G>A	c.(4171-4173)Gag>Aag	p.E1391K	CIC_ENST00000575354.2_Missense_Mutation_p.E482K|CIC_ENST00000160740.3_Missense_Mutation_p.E482K			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	482					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CAGCTCTGGGGAGGACCCAGA	0.602000			"""Mis, F, S"""		oligodendroglioma								4	13					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156277025	156277025	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:156277025G>C	ENST00000311277.4	-	9	1396	c.1133C>G	c.(1132-1134)tCt>tGt	p.S378C	AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000593387.1_RNA|AC097467.2_ENST00000417474.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.S354C	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	378					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CAAAAACTCAGAGGTCATTAA	0.328000													11	37					0	0	1	0	0
GMFB	2764	broad.mit.edu	37	14	54950444	54950444	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr14:54950444C>T	ENST00000554908.1	-	2	142	c.45G>A	c.(43-45)gtG>gtA	p.V15V	GMFB_ENST00000358056.3_Silent_p.V15V|GMFB_ENST00000553566.1_5'UTR			P60983	GMFB_HUMAN	glia maturation factor, beta	15	ADF-H.				nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)	8						TCAGCTTTTCCACTAAATCTT	0.328000													17	105					0	0	1	0	0
NUDT22	84304	broad.mit.edu	37	11	63994194	63994194	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:63994194G>A	ENST00000279206.3	+	2	226	c.70G>A	c.(70-72)Gag>Aag	p.E24K	NUDT22_ENST00000441250.2_Missense_Mutation_p.E24K	NM_001128612.2|NM_032344.2	NP_001122084.1|NP_115720.1	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 22	24							hydrolase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8						GATACAGGCCGAGCTGAGCCC	0.667000													17	60					0	0	1	0	0
ZNF416	55659	broad.mit.edu	37	19	58083539	58083539	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:58083539C>T	ENST00000196489.3	-	4	1955	c.1733G>A	c.(1732-1734)cGt>cAt	p.R578H		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	578					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		GCTGCTGTCACGAGGCCTCTC	0.468000													6	270					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42858745	42858745	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:42858745G>A	ENST00000455697.1	-	7	1376	c.1091C>T	c.(1090-1092)tCa>tTa	p.S364L	PRICKLE1_ENST00000445766.2_Missense_Mutation_p.S364L|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.S364L|RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.S364L|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.S364L	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	364					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		AGCATTGCCTGAGAGGCCAGG	0.483000													28	79					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66458979	66458979	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:66458979C>T	ENST00000533211.1	-	27	5672	c.5341G>A	c.(5341-5343)Gag>Aag	p.E1781K	SPTBN2_ENST00000309996.2_Missense_Mutation_p.E1781K|SPTBN2_ENST00000529997.1_Missense_Mutation_p.E1781K			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1781					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton	p.E1781K(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						GCCCAGGCCTCGTTGAGACTG	0.672000													14	38					0	0	1	0	0
HOOK1	51361	broad.mit.edu	37	1	60314090	60314090	+	Nonsense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:60314090G>T	ENST00000371208.3	+	11	1290	c.1033G>T	c.(1033-1035)Gaa>Taa	p.E345*	HOOK1_ENST00000395561.2_Nonsense_Mutation_p.E303*|HOOK1_ENST00000465876.1_3'UTR	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	345	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					AACTTTACAGGAAACCAACAT	0.363000													32	90					1.62565e-12	1.71352e-12	1	1	0
PLCB4	5332	broad.mit.edu	37	20	9400478	9400478	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr20:9400478G>A	ENST00000378501.2	+	22	2055	c.2040G>A	c.(2038-2040)atG>atA	p.M680I	PLCB4_ENST00000278655.4_Missense_Mutation_p.M680I|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378473.3_Missense_Mutation_p.M692I|PLCB4_ENST00000414679.2_Missense_Mutation_p.M692I|PLCB4_ENST00000378493.1_Missense_Mutation_p.M680I|PLCB4_ENST00000334005.3_Missense_Mutation_p.M680I	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	680	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity	p.M680I(1)		NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CAGATTTCATGAGGCGGCCTG	0.438000													36	126					0	0	1	0	0
RNF14	9604	broad.mit.edu	37	5	141357914	141357914	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr5:141357914G>A	ENST00000394520.2	+	5	662	c.353G>A	c.(352-354)cGt>cAt	p.R118H	RNF14_ENST00000356143.1_Missense_Mutation_p.R118H|RNF14_ENST00000394514.2_5'UTR|RNF14_ENST00000394519.1_Missense_Mutation_p.R118H|RNF14_ENST00000502341.1_3'UTR|RNF14_ENST00000540015.1_Intron|RNF14_ENST00000347642.3_Missense_Mutation_p.R118H|AC005740.5_ENST00000520882.1_RNA|RNF14_ENST00000394515.3_Intron	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	118	RWD.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GAAGAACACCGTGGCAGCGTG	0.453000													25	81					0	0	1	0	0
TRNT1	51095	broad.mit.edu	37	3	3170787	3170787	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:3170787C>T	ENST00000251607.6	+	2	165	c.63C>T	c.(61-63)tgC>tgT	p.C21C	TRNT1_ENST00000402675.1_Silent_p.C21C|TRNT1_ENST00000339437.6_Silent_p.C21C|TRNT1_ENST00000280591.6_Silent_p.C21C|TRNT1_ENST00000469632.1_3'UTR|TRNT1_ENST00000420393.1_Silent_p.C21C	NM_182916.2	NP_886552.2	Q96Q11	TRNT1_HUMAN	tRNA nucleotidyl transferase, CCA-adding, 1	21					protein targeting to mitochondrion|tRNA 3'-end processing	mitochondrion	ATP binding|tRNA adenylyltransferase activity|tRNA binding			breast(2)|endometrium(3)|large_intestine(4)|lung(2)|urinary_tract(1)	12				Epithelial(13;0.00226)|OV - Ovarian serous cystadenocarcinoma(96;0.00592)|all cancers(10;0.011)		GTAGGCTGTGCCTTCCGAAGC	0.493000													4	115					0	0	1	0	0
RASSF5	83593	broad.mit.edu	37	1	206681310	206681310	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:206681310C>T	ENST00000338603.2	+	1	432	c.375C>T	c.(373-375)ttC>ttT	p.F125F	RASSF5_ENST00000355294.4_Silent_p.F125F|RASSF5_ENST00000367117.3_Silent_p.F125F	NM_182663.2	NP_872604.1	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family member 5	125					apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	8	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GGCACTGCTTCGCCGAGTTGG	0.726000													4	7					0	0	1	0	0
C1orf52	148423	broad.mit.edu	37	1	85724231	85724231	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:85724231C>T	ENST00000471115.1	-	2	459	c.451G>A	c.(451-453)Gaa>Aaa	p.E151K	C1orf52_ENST00000294661.4_5'UTR|C1orf52_ENST00000344356.5_Missense_Mutation_p.E151K	NM_198077.3	NP_932343.1	Q8N6N3	CA052_HUMAN	chromosome 1 open reading frame 52	151										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)	10				all cancers(265;0.0105)|Epithelial(280;0.0293)		TCCTCCCCTTCTGGTAGAAGC	0.433000													51	169					0	0	1	0	0
PSMD6	9861	broad.mit.edu	37	3	64005073	64005073	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:64005073C>T	ENST00000492933.1	-	4	607	c.555G>A	c.(553-555)gtG>gtA	p.V185V	PSMD6_ENST00000295901.4_Silent_p.V132V|PSMD6_ENST00000394431.2_Silent_p.V94V|PSMD6_ENST00000482510.1_Silent_p.V93V	NM_001271779.1	NP_001258708.1	Q15008	PSMD6_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	132					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	ATPase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(1)	13		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000805)|Kidney(15;0.00188)|KIRC - Kidney renal clear cell carcinoma(15;0.00212)		GACCCAGGGCCACAGTTTTGT	0.418000													7	78					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12385822	12385822	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:12385822C>G	ENST00000356109.5	-	4	419	c.301G>C	c.(301-303)Gat>Cat	p.D101H	ZNF44_ENST00000355684.5_Missense_Mutation_p.D53H	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	101	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		TGCTGATCATCAATGTTCTGG	0.313000													5	33					0	0	1	0	0
CCDC142	84865	broad.mit.edu	37	2	74709080	74709080	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:74709080G>A	ENST00000393965.3	-	1	1281	c.885C>T	c.(883-885)ctC>ctT	p.L295L	CCDC142_ENST00000471713.1_5'UTR|CCDC142_ENST00000290418.4_Silent_p.L295L	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	295										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						CAGCCCCTCCGAGCCCTAGTC	0.677000													21	43					0	0	1	0	0
PRPF3	9129	broad.mit.edu	37	1	150307683	150307683	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:150307683G>C	ENST00000324862.6	+	7	1171	c.1006G>C	c.(1006-1008)Gag>Cag	p.E336Q	PRPF3_ENST00000543398.1_Missense_Mutation_p.E201Q|PRPF3_ENST00000414970.2_Missense_Mutation_p.E287Q|PRPF3_ENST00000467329.1_3'UTR	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	336					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		GGGCAAATTTGAGAAGATTGC	0.413000													14	75					0	0	1	0	0
DAK	26007	broad.mit.edu	37	11	61113381	61113381	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:61113381G>A	ENST00000394900.3	+	17	1767	c.1538G>A	c.(1537-1539)gGa>gAa	p.G513E		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	513	DhaL.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						AAGAGCCCAGGAGCTGATCTG	0.617000													17	60					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50367073	50367073	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:50367073C>G	ENST00000315520.5	+	1	454	c.117C>G	c.(115-117)ttC>ttG	p.F39L	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	39					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity	p.F39L(1)		endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						TGTATGTGTTCTTTGGCGTGG	0.612000													39	119					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170873697	170873697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:170873697C>T	ENST00000392092.2	+	4	841	c.562C>T	c.(562-564)Cga>Tga	p.R188*	TBP_ENST00000230354.6_Nonsense_Mutation_p.R188*|TBP_ENST00000540980.1_Nonsense_Mutation_p.R168*	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	188					cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		ACTTCGTGCCCGAAACGCCGA	0.318000													4	83					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117240818	117240818	+	Silent	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:117240818C>A	ENST00000374057.3	-	2	1500	c.852G>T	c.(850-852)ggG>ggT	p.G284G	DFNB31_ENST00000362057.3_Intron|DFNB31_ENST00000265134.6_Intron			Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	284	PDZ 2.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGCCTCCTTTCCCCACCCCAC	0.632000													12	51					6.81908e-15	7.21554e-15	1	1	0
KRT76	51350	broad.mit.edu	37	12	53170978	53170978	+	Missense_Mutation	SNP	A	A	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:53170978A>T	ENST00000332411.2	-	1	151	c.98T>A	c.(97-99)gTg>gAg	p.V33E		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	33	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGAGCGGGCCACACAGCTCAT	0.607000													5	113					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157729	26157729	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:26157729G>A	ENST00000325250.1	+	2	814	c.627G>A	c.(625-627)ctG>ctA	p.L209L		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	209	MAGE.						protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						TGATCTTTCTGAATGGCAACC	0.458000													12	41					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123336558	123336558	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:123336558G>C	ENST00000296513.2	+	11	1459	c.1274G>C	c.(1273-1275)aGa>aCa	p.R425T	ADAD1_ENST00000388724.2_Missense_Mutation_p.R414T|ADAD1_ENST00000388725.2_Missense_Mutation_p.R407T	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	425	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						AGTGATACCAGAGGCTTAGAA	0.338000													23	92					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26753036	26753036	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:26753036C>T	ENST00000381340.3	-	29	4101	c.3685G>A	c.(3685-3687)Gaa>Aaa	p.E1229K		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1229					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TTCATCTTTTCATCATTCTGT	0.338000													9	48					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17614170	17614170	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr20:17614170C>T	ENST00000377813.1	-	8	2848	c.2545G>A	c.(2545-2547)Gag>Aag	p.E849K	RRBP1_ENST00000360807.4_Missense_Mutation_p.E416K|RRBP1_ENST00000246043.4_Missense_Mutation_p.E849K|RRBP1_ENST00000377807.2_Missense_Mutation_p.E416K|RRBP1_ENST00000455029.2_Missense_Mutation_p.E190K			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	849					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						CGCTGCTGCTCATCTTGCCGC	0.612000													14	49					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111022220	111022220	+	Missense_Mutation	SNP	T	T	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:111022220T>G	ENST00000262839.2	-	10	3143	c.2225A>C	c.(2224-2226)aAt>aCt	p.N742T		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	742					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TACCTTAAAATTTTCTTCTGT	0.318000													14	66					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119533	19119533	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:19119533C>T	ENST00000399635.2	+	1	1213	c.621C>T	c.(619-621)taC>taT	p.Y207Y	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	207	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					TGATCCTGTACATCATGGTCT	0.602000													34	122					0	0	1	0	0
ACP2	53	broad.mit.edu	37	11	47270244	47270244	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:47270244G>A	ENST00000256997.3	-	1	213	c.97C>T	c.(97-99)Ctg>Ttg	p.L33L	ACP2_ENST00000527256.1_Silent_p.L33L|ACP2_ENST00000444355.2_Silent_p.L33L|ACP2_ENST00000537863.1_5'UTR|ACP2_ENST00000529444.1_Silent_p.L33L|ACP2_ENST00000529788.1_Silent_p.L33L|NR1H3_ENST00000529540.1_3'UTR|ACP2_ENST00000530453.1_Silent_p.L33L	NM_001610.2	NP_001601.1	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal	33						integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)	10						ACGAAGCGCAGACTCCGGGCC	0.637000													4	10					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204948662	204948662	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:204948662C>T	ENST00000367172.4	+	19	2479	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S	NFASC_ENST00000339876.6_Silent_p.S717S|NFASC_ENST00000360049.4_Silent_p.S713S|NFASC_ENST00000404907.1_Silent_p.S713S|NFASC_ENST00000513543.1_Silent_p.S713S|NFASC_ENST00000404076.1_Silent_p.S696S|NFASC_ENST00000367171.4_Silent_p.S702S|NFASC_ENST00000338515.6_Silent_p.S717S|NFASC_ENST00000401399.1_Silent_p.S717S|NFASC_ENST00000539706.1_Silent_p.S713S|NFASC_ENST00000338586.6_Silent_p.S717S|NFASC_ENST00000367169.4_Silent_p.S717S|NFASC_ENST00000367170.4_Silent_p.S717S			O94856	NFASC_HUMAN	neurofascin	717	Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GCCTCCCATCCGAGCGCTACC	0.622000													38	145					0	0	1	0	0
KCNAB3	9196	broad.mit.edu	37	17	7826832	7826832	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:7826832G>C	ENST00000303790.2	-	13	1078	c.1079C>G	c.(1078-1080)tCt>tGt	p.S360C		NM_004732.3	NP_004723.2	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 3	360						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	8		Prostate(122;0.157)				CAGCAAGACAGAGCTGACACC	0.582000													5	13					0	0	1	0	0
REPS1	85021	broad.mit.edu	37	6	139241392	139241392	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:139241392C>G	ENST00000450536.2	-	12	2062	c.1488G>C	c.(1486-1488)aaG>aaC	p.K496N	REPS1_ENST00000409812.2_Missense_Mutation_p.K469N|REPS1_ENST00000258062.5_Missense_Mutation_p.K496N|REPS1_ENST00000367663.4_Missense_Mutation_p.K469N|REPS1_ENST00000415951.2_Missense_Mutation_p.K469N			Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	496						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	19				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		ATGAATTTATCTTATTTTCTT	0.328000													26	100					0	0	1	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38413282	38413282	+	Silent	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:38413282G>C	ENST00000377694.1	-	3	661	c.639C>G	c.(637-639)gtC>gtG	p.V213V		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	213	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		CTCGCACTTGGACAGCTATAT	0.537000													16	71					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14763808	14763808	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr18:14763808C>T	ENST00000358984.4	+	7	1124	c.944C>T	c.(943-945)gCc>gTc	p.A315V	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Missense_Mutation_p.A315V	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	315										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						GGAACGTCTGCCAAAATTCAA	0.478000													5	23					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23240675	23240675	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr14:23240675C>T	ENST00000358043.5	+	10	1486	c.1168C>T	c.(1168-1170)Ctc>Ttc	p.L390F	OXA1L_ENST00000412791.1_Missense_Mutation_p.L379F|OXA1L_ENST00000604262.1_Missense_Mutation_p.L406F|OXA1L_ENST00000285848.5_Missense_Mutation_p.L466F			Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	406					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		CCACAACCCTCTCCTACAACC	0.453000													36	148					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85441762	85441762	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr8:85441762G>C	ENST00000521268.1	+	2	1311	c.206G>C	c.(205-207)aGa>aCa	p.R69T	RALYL_ENST00000521695.1_Missense_Mutation_p.R69T|RALYL_ENST00000518566.1_Missense_Mutation_p.R69T|RALYL_ENST00000517638.1_Missense_Mutation_p.R82T|RALYL_ENST00000522455.1_Missense_Mutation_p.R69T	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	69	RRM.						identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						CGACATGCAAGAGCTGCAGTG	0.428000													14	63					0	0	1	0	0
STAG3L2	442582	broad.mit.edu	37	7	74301262	74301262	+	RNA	SNP	T	T	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:74301262T>A	ENST00000423186.1	-	0	499							P0CL84	ST3L2_HUMAN								nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						AGGACATCCCTAGACACAGAC	0.443000													86	322					0	0	1	0	0
IGLV2-18	28814	broad.mit.edu	37	22	23077464	23077464	+	RNA	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:23077464G>A	ENST00000390310.2	+	0	254																											AGGGGTCCCTGATCGCTTCTC	0.552000													85	246					0	0	1	0	0
PRPF3	9129	broad.mit.edu	37	1	150321635	150321635	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:150321635G>A	ENST00000324862.6	+	15	2011	c.1846G>A	c.(1846-1848)Gat>Aat	p.D616N	PRPF3_ENST00000414970.2_Missense_Mutation_p.D567N|PRPF3_ENST00000467329.1_3'UTR	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	616					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		TCTTCCAGATGATGAGGAGTC	0.363000													29	126					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241535885	241535885	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:241535885C>T	ENST00000391984.2	+	8	1624	c.1428C>T	c.(1426-1428)gaC>gaT	p.D476D	CAPN10_ENST00000404753.3_Silent_p.D476D|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000354082.4_Intron|CAPN10_ENST00000352879.4_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	476	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TCCTGAAGGACGCGCCAGGGG	0.657000													56	59					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20736542	20736542	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:20736542C>G	ENST00000427401.4	-	2	197	c.103G>C	c.(103-105)Gag>Cag	p.E35Q	ZNF737_ENST00000596797.1_Missense_Mutation_p.E35Q	NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	35					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						CTGTAGTTCTCTAACATCACA	0.378000													38	170					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101910480	101910480	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:101910480G>A	ENST00000537097.1	+	6	2452	c.1639G>A	c.(1639-1641)Gaa>Aaa	p.E547K	GPRASP1_ENST00000361600.5_Missense_Mutation_p.E547K|GPRASP1_ENST00000444152.1_Missense_Mutation_p.E547K|GPRASP1_ENST00000415986.1_Missense_Mutation_p.E547K|RP4-769N13.7_ENST00000602441.1_RNA	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	547	Glu-rich.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GTCTGAGGAAGAAGAGGTCAT	0.512000													55	200					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43617453	43617453	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:43617453G>A	ENST00000355710.3	+	16	3022	c.2790G>A	c.(2788-2790)acG>acA	p.T930T	RET_ENST00000340058.5_Silent_p.T930T	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	930	Protein kinase.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	TCTACACCACGCAAAGTGATG	0.453000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				29	178					0	0	1	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101572436	101572436	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:101572436C>T	ENST00000326172.5	+	5	1181	c.1066C>T	c.(1066-1068)Ccc>Tcc	p.P356S	NFKBIZ_ENST00000326151.5_Intron|NFKBIZ_ENST00000394054.2_Missense_Mutation_p.P256S	NM_031419.3	NP_113607.1	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	356	Required for transcriptional activity (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						TATTGCTAATCCCATGCAGAC	0.488000													42	106					0	0	1	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451624	22451624	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:22451624C>G	ENST00000325870.1	+	2	1454	c.1229C>G	c.(1228-1230)tCt>tGt	p.S410C		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	410					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		TCAGCTTTCTCTCCTCTTCAA	0.408000													35	129					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231853	7231853	+	Silent	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr18:7231853C>G	ENST00000383467.2	+	1	731	c.717C>G	c.(715-717)ctC>ctG	p.L239L		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	239										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TGCTGAACCTCAACAACAATG	0.577000													20	76					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887399	12887399	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:12887399C>G	ENST00000535591.1	-	3	653	c.458G>C	c.(457-459)cGc>cCc	p.R153P		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	153										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						TCTGATATTGCGGAAGGGCAT	0.468000													109	449					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32163492	32163492	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:32163492G>A	ENST00000375023.3	-	30	5872	c.5734C>T	c.(5734-5736)Cgc>Tgc	p.R1912C	NOTCH4_ENST00000443903.2_3'UTR	NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1912					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CTACGGCCGCGAGGGGTCGGG	0.687000													15	71					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24460775	24460775	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:24460775G>A	ENST00000270800.1	-	4	495	c.457C>T	c.(457-459)Cgg>Tgg	p.R153W		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	153	Fibronectin type-III 2.					integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		AGGGTTAGCCGGTGGCCATCG	0.522000													4	49					0	0	1	0	0
TTC1	7265	broad.mit.edu	37	5	159437680	159437680	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr5:159437680G>A	ENST00000231238.5	+	2	255	c.145G>A	c.(145-147)Gat>Aat	p.D49N	TTC1_ENST00000522793.1_Missense_Mutation_p.D49N	NM_003314.1	NP_003305.1	Q99614	TTC1_HUMAN	tetratricopeptide repeat domain 1	49					protein folding		unfolded protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|prostate(1)|skin(1)	12	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)		GCTCAGGGATGATGAGGCCCA	0.517000													12	39					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57317567	57317567	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:57317567G>A	ENST00000457912.1	+	8	1521	c.1521G>A	c.(1519-1521)gtG>gtA	p.V507V	SMTNL1_ENST00000399154.2_Silent_p.V452V|SMTNL1_ENST00000527972.1_Silent_p.V489V			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	489										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AAGGACTGGTGAAGACCAAGA	0.597000													4	17					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112175771	112175771	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr5:112175771G>C	ENST00000457016.1	+	16	4860	c.4480G>C	c.(4480-4482)Gaa>Caa	p.E1494Q	APC_ENST00000508376.2_Missense_Mutation_p.E1494Q|APC_ENST00000257430.4_Missense_Mutation_p.E1494Q|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1494	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1494fs*13(7)|p.E1494fs*19(3)|p.?(1)|p.K1454fs*3(1)|p.L1488fs*13(1)|p.S1495fs*19(1)|p.K1192fs*3(1)|p.T1493fs*13(1)|p.E1494*(1)|p.E1494fs*12(1)|p.E1494fs*11(1)|p.T1493fs*17(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTTTGCCACGGAAAGTACTCC	0.438000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			22	114					0	0	1	0	0
DDX1	1653	broad.mit.edu	37	2	15758387	15758387	+	Missense_Mutation	SNP	G	G	C	rs146515867		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:15758387G>C	ENST00000381341.2	+	17	1588	c.1199G>C	c.(1198-1200)aGa>aCa	p.R400T	DDX1_ENST00000233084.3_Missense_Mutation_p.R400T			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1	400	Helicase ATP-binding.|Necessary for interaction with RELA.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity	p.R400T(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		GATGGAAAAAGACTTCAGGTA	0.368000													22	121					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81056365	81056365	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:81056365C>T	ENST00000334512.5	+	13	1940	c.1368C>T	c.(1366-1368)tcC>tcT	p.S456S	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	456	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGCCGAGCTCCGGGCAGTACC	0.677000													11	67					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80789502	80789502	+	Nonsense_Mutation	SNP	C	C	A	rs35283702	byFrequency	TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:80789502C>A	ENST00000269394.3	-	2	1662	c.829G>T	c.(829-831)Gga>Tga	p.G277*	TBCD_ENST00000397466.2_Intron|TBCD_ENST00000539345.2_Intron|ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000355528.4_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	277						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TCTTGGGTTCCGTAGACTGAC	0.597000													67	86					5.10508e-28	5.61971e-28	1	1	0
FAM110C	642273	broad.mit.edu	37	2	45627	45627	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:45627G>A	ENST00000327669.4	-	1	758	c.759C>T	c.(757-759)gtC>gtT	p.V253V		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	253						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		CGGAGGTGGCGACGCTCACGC	0.692000													10	27					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886265	9886265	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr18:9886265G>A	ENST00000306084.6	+	1	293	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K	TXNDC2_ENST00000357775.4_Intron|TXNDC2_ENST00000536353.2_Intron|TXNDC2_ENST00000426718.3_Missense_Mutation_p.E32K|TXNDC2_ENST00000584255.1_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	32					cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AGAAACAAGTGAAGGTGATGC	0.473000													7	20					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32382754	32382754	+	Missense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:32382754G>T	ENST00000357033.4	-	36	5305	c.5099C>A	c.(5098-5100)aCa>aAa	p.T1700K	DMD_ENST00000378677.2_Missense_Mutation_p.T1696K	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1700	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATCCAAAAGTGTGTCAGCCTG	0.383000													33	146					2.08457e-15	2.21435e-15	1	1	0
ZNF606	80095	broad.mit.edu	37	19	58491078	58491078	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:58491078G>C	ENST00000341164.4	-	7	1590	c.970C>G	c.(970-972)Caa>Gaa	p.Q324E	ZNF606_ENST00000536132.1_Missense_Mutation_p.Q234E	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TTAAAGATTTGATGGCATTCC	0.313000													31	78					0	0	1	0	0
USP42	84132	broad.mit.edu	37	7	6150815	6150815	+	Missense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:6150815G>T	ENST00000306177.5	+	2	209	c.51G>T	c.(49-51)caG>caT	p.Q17H		NM_032172.2	NP_115548.1	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	17					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(2)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	35		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		CAGCCTATCAGAATCAGCCTG	0.458000													6	26					0.0215528	0.021632	1	1	0
CDH18	1016	broad.mit.edu	37	5	19483611	19483611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr5:19483611G>A	ENST00000507958.1	-	14	2671	c.1681C>T	c.(1681-1683)Cag>Tag	p.Q561*	CDH18_ENST00000382275.1_Nonsense_Mutation_p.Q561*|CDH18_ENST00000502796.1_Intron|CDH18_ENST00000274170.4_Nonsense_Mutation_p.Q561*|CDH18_ENST00000506372.1_Intron			Q13634	CAD18_HUMAN	cadherin 18, type 2	561	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TACACATCCTGAACAGTTCGA	0.463000													13	55					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48056379	48056379	+	Missense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr15:48056379G>T	ENST00000316364.5	+	11	1413	c.974G>T	c.(973-975)gGt>gTt	p.G325V	SEMA6D_ENST00000389428.3_Missense_Mutation_p.G325V|SEMA6D_ENST00000389425.3_Missense_Mutation_p.G325V|SEMA6D_ENST00000537942.1_Missense_Mutation_p.G325V|SEMA6D_ENST00000536845.2_Missense_Mutation_p.G325V|SEMA6D_ENST00000354744.4_Missense_Mutation_p.G325V|SEMA6D_ENST00000358066.4_Missense_Mutation_p.G325V|SEMA6D_ENST00000558816.1_Missense_Mutation_p.G325V|SEMA6D_ENST00000558014.1_Missense_Mutation_p.G325V|SEMA6D_ENST00000389433.2_Missense_Mutation_p.G325V|SEMA6D_ENST00000389432.2_Missense_Mutation_p.G325V|SEMA6D_ENST00000355997.3_Missense_Mutation_p.G325V	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	325	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AGCATCCCTGGTTCTGCTGTC	0.458000													35	124					1.49673e-21	1.62146e-21	1	1	0
TNFAIP1	7126	broad.mit.edu	37	17	26671454	26671454	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:26671454G>A	ENST00000226225.2	+	7	1046	c.779G>A	c.(778-780)cGc>cAc	p.R260H	TNFAIP1_ENST00000544907.2_Missense_Mutation_p.R156H|TNFAIP1_ENST00000583213.1_3'UTR	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	260					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GAGACTCCCCGCGTCCCCGAC	0.587000													19	49					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50315639	50315639	+	Splice_Site	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:50315639C>T	ENST00000332853.3	-	2	480	c.457_splice	c.e2+1	p.V153_splice	VSTM4_ENST00000298454.3_Splice_Site_p.G153_splice	NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	153	Ig-like.					integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						AGACCCTCACCTCTCATTTCC	0.622000													11	39					0	0	1	0	0
CLDN4	1364	broad.mit.edu	37	7	73245893	73245893	+	Missense_Mutation	SNP	C	C	T	rs138373200		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:73245893C>T	ENST00000435050.1	+	2	3042	c.362C>T	c.(361-363)gCg>gTg	p.A121V	CLDN4_ENST00000340958.2_Missense_Mutation_p.A121V|CLDN4_ENST00000431918.1_Missense_Mutation_p.A121V			O14493	CLD4_HUMAN	claudin 4	121					calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity			kidney(2)|lung(4)|urinary_tract(1)	7		Lung NSC(55;0.159)				ATGATCGTGGCGGGCGTGGTG	0.607000													16	33					0	0	1	0	0
KIF11	3832	broad.mit.edu	37	10	94405203	94405203	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:94405203G>A	ENST00000260731.3	+	18	2441	c.2351G>A	c.(2350-2352)aGa>aAa	p.R784K		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	784					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAGGAACTCAGAAATTTTAAC	0.343000													24	57					0	0	1	0	0
PIAS2	9063	broad.mit.edu	37	18	44409730	44409730	+	Missense_Mutation	SNP	T	T	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr18:44409730T>C	ENST00000585916.1	-	10	1302	c.1303A>G	c.(1303-1305)Aaa>Gaa	p.K435E	PIAS2_ENST00000324794.7_Missense_Mutation_p.K435E|PIAS2_ENST00000545673.1_Missense_Mutation_p.K145E	NM_004671.3	NP_004662.2	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT, 2	435					androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	22						CTGGATACTTTCATAGCTTCT	0.388000													50	214					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113285336	113285336	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:113285336C>T	ENST00000264852.4	+	2	1018	c.292C>T	c.(292-294)Cgc>Tgc	p.R98C	SIDT1_ENST00000393830.3_Missense_Mutation_p.R98C	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	98						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						TGTTGTGGTTCGCCAGCAGAA	0.493000													30	133					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117128338	117128338	+	Missense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:117128338C>A	ENST00000310357.3	-	3	551	c.530G>T	c.(529-531)aGt>aTt	p.S177I	GPRC6A_ENST00000530250.1_Missense_Mutation_p.S177I|GPRC6A_ENST00000368549.3_Missense_Mutation_p.S177I	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	177					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AATTTTGTCACTCAGGATTTC	0.408000													26	145					4.72057e-08	4.82665e-08	1	1	0
HMCN1	83872	broad.mit.edu	37	1	186045667	186045667	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:186045667G>A	ENST00000271588.4	+	54	8627	c.8398G>A	c.(8398-8400)Gag>Aag	p.E2800K	HMCN1_ENST00000367492.2_Missense_Mutation_p.E2800K	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2800	Ig-like C2-type 26.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCTTTACTGTGAGACAAATGC	0.418000													21	75					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100777052	100777052	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:100777052C>G	ENST00000223095.4	+	5	934	c.777C>G	c.(775-777)ttC>ttG	p.F259L	SERPINE1_ENST00000445463.2_Missense_Mutation_p.F244L	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	259					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	TCAGCATGTTCATTGCTGCCC	0.552000													19	82					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39876601	39876601	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:39876601C>T	ENST00000530275.1	+	1	451	c.256C>T	c.(256-258)Cag>Tag	p.Q86*	MACF1_ENST00000564288.1_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000289893.4_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000567887.1_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	86	13 X 13 AA approximate tandem repeat of P-T-S-P-A-A-A-V-P-T-P-E-E.									central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTTTAGATTTCAGCAGCACAG	0.433000											OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	76					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62377166	62377166	+	Translation_Start_Site	SNP	C	C	T	rs143147555	byFrequency	TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:62377166C>T	ENST00000531557.1	-	0	131				EML3_ENST00000494176.2_Missense_Mutation_p.R162H|EML3_ENST00000529309.1_Missense_Mutation_p.R190H|EML3_ENST00000394773.2_Missense_Mutation_p.R190H|EML3_ENST00000278845.4_Missense_Mutation_p.R191H			Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3							cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						TTTTCCCCCACGGCTGTTGGG	0.552000													6	215					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	558218	558218	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:558218C>T	ENST00000329451.3	-	4	404	c.342G>A	c.(340-342)caG>caA	p.Q114Q	RP11-496I9.1_ENST00000527620.1_RNA	NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	114										NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGACCTGGTTCTGCAGGAGTT	0.627000													54	76					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49847986	49847986	+	Silent	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:49847986G>C	ENST00000333486.3	-	12	1589	c.1431C>G	c.(1429-1431)ctC>ctG	p.L477L		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	477	2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		ACTGACGGCTGAGATTGGAGC	0.592000													54	210					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171384	150171384	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:150171384G>A	ENST00000307271.3	+	4	1541	c.967G>A	c.(967-969)Ggc>Agc	p.G323S		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	323						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CATCTGTACAGGCCCCCATGC	0.428000													14	97					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202698874	202698874	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:202698874G>A	ENST00000367265.3	-	26	5622	c.4458C>T	c.(4456-4458)atC>atT	p.I1486I	KDM5B_ENST00000367264.2_Silent_p.I1522I	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1486					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CAGCTGGGCAGATGGCATCTT	0.507000													28	102					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31602773	31602773	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr14:31602773G>A	ENST00000399332.1	-	23	4175	c.3687C>T	c.(3685-3687)ctC>ctT	p.L1229L	HECTD1_ENST00000553700.1_Silent_p.L1229L	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1229					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CAGATAATGAGAGGTAGTGTG	0.403000													27	109					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5047575	5047575	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:5047575C>T	ENST00000159111.4	+	6	739	c.521C>T	c.(520-522)aCg>aTg	p.T174M	KDM4B_ENST00000592175.1_3'UTR|KDM4B_ENST00000536461.1_Missense_Mutation_p.T174M|KDM4B_ENST00000381759.4_Missense_Mutation_p.T174M	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	174	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GGCGTGAACACGCCCTACCTG	0.622000													29	98					0	0	1	0	0
CCAR2	57805	broad.mit.edu	37	8	22473750	22473750	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr8:22473750G>A	ENST00000308511.4	+	14	2083	c.1834G>A	c.(1834-1836)Gag>Aag	p.E612K	KIAA1967_ENST00000389279.3_Missense_Mutation_p.E612K|RP11-582J16.5_ENST00000521025.1_RNA|KIAA1967_ENST00000520861.1_Missense_Mutation_p.E287K			Q8N163	K1967_HUMAN		612					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(5)	25		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TACAGAGTCAGAGGCCCCGCT	0.612000													35	81					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36168550	36168550	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:36168550G>A	ENST00000357641.6	+	2	704	c.451G>A	c.(451-453)Gag>Aag	p.E151K	BRPF3_ENST00000534694.1_Missense_Mutation_p.E151K|BRPF3_ENST00000443324.2_Missense_Mutation_p.E151K|BRPF3_ENST00000534400.1_Missense_Mutation_p.E151K|BRPF3_ENST00000339717.7_Missense_Mutation_p.E151K|BRPF3_ENST00000543502.1_Missense_Mutation_p.E151K	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	151					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						CCTGGATGCAGAGGTAGAGTA	0.547000													13	51					0	0	1	0	0
LEF1	51176	broad.mit.edu	37	4	109086270	109086270	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:109086270C>T	ENST00000379951.2	-	2	1451	c.263G>A	c.(262-264)aGa>aAa	p.R88K	LEF1_ENST00000512172.1_Missense_Mutation_p.R20K|LEF1_ENST00000438313.2_Missense_Mutation_p.R88K|LEF1_ENST00000510624.1_Missense_Mutation_p.R20K|LEF1_ENST00000265165.1_Missense_Mutation_p.R88K	NM_001130713.2|NM_001130714.2	NP_001124185.1|NP_001124186.1	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1	88	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	25				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GGGGTGTTCTCTGGCCTTGTC	0.443000													28	98					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615321	179615321	+	Nonsense_Mutation	SNP	G	G	A	rs147087155	by1000genomes	TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:179615321G>A	ENST00000360870.5	-	46	12028	c.11806C>T	c.(11806-11808)Cga>Tga	p.R3936*	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9753							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCGTTTTCGAAAAGAATTT	0.353000													21	67					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31662976	31662976	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:31662976C>T	ENST00000331728.4	+	9	1162	c.1048C>T	c.(1048-1050)Cac>Tac	p.H350Y	LIMK2_ENST00000406516.1_Missense_Mutation_p.H272Y|LIMK2_ENST00000340552.4_Missense_Mutation_p.H329Y|LIMK2_ENST00000444929.2_Missense_Mutation_p.H104Y|LIMK2_ENST00000333611.4_Missense_Mutation_p.H329Y	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	350	Protein kinase.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						GTAGGTGACACACAAAGCCAC	0.488000													9	30					0	0	1	0	0
PDE4B	5142	broad.mit.edu	37	1	66833738	66833738	+	Missense_Mutation	SNP	A	A	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:66833738A>T	ENST00000423207.2	+	13	2092	c.1607A>T	c.(1606-1608)gAt>gTt	p.D536V	PDE4B_ENST00000371045.5_Missense_Mutation_p.D379V|PDE4B_ENST00000371049.3_Missense_Mutation_p.D551V|PDE4B_ENST00000329654.4_Missense_Mutation_p.D551V|PDE4B_ENST00000480109.2_Missense_Mutation_p.D318V	NM_001037340.1	NP_001032417.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	551					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AACTATACCGATCGCATTCAG	0.363000													4	64					0	0	1	0	0
LRRC71	149499	broad.mit.edu	37	1	156897772	156897772	+	Silent	SNP	A	A	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:156897772A>G	ENST00000337428.7	+	9	1126	c.972A>G	c.(970-972)aaA>aaG	p.K324K	LRRC71_ENST00000490146.1_3'UTR	NM_144702.2	NP_653303.2	Q8N4P6	LRC71_HUMAN	leucine rich repeat containing 71	324										endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|stomach(1)	12						TGCTGGAAAAAGGGACACAGG	0.677000											OREG0013892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	31					0	0	1	0	0
CRY2	1408	broad.mit.edu	37	11	45892066	45892066	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:45892066C>T	ENST00000443527.2	+	9	1617	c.1595C>T	c.(1594-1596)tCg>tTg	p.S532L	CRY2_ENST00000417225.2_Missense_Mutation_p.S450L	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	511					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						CAGCAGCTTTCGCGCTACCGG	0.542000													13	40					0	0	1	0	0
CCNA1	8900	broad.mit.edu	37	13	37006796	37006796	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr13:37006796C>G	ENST00000418263.1	+	1	388	c.38C>G	c.(37-39)tCt>tGt	p.S13C	CCNA1_ENST00000255465.4_Missense_Mutation_p.S13C|CCNA1_ENST00000440264.1_Intron|CCNA1_ENST00000463403.1_Intron|CCNA1_ENST00000449823.1_Intron	NM_001111045.1|NM_003914.3	NP_001104515.1|NP_003905.1	P78396	CCNA1_HUMAN	cyclin A1	13					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		TACCCTGGATCTTTTATTGGG	0.587000													6	34					0	0	1	0	0
LANCL3	347404	broad.mit.edu	37	X	37431383	37431383	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:37431383C>T	ENST00000378621.3	+	1	562	c.260C>T	c.(259-261)aCg>aTg	p.T87M	LANCL3_ENST00000378619.3_Missense_Mutation_p.T87M|TM4SF2_ENST00000465127.1_Intron	NM_198511.2	NP_940913.1	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3 (bacterial)	87							catalytic activity			lung(4)|pancreas(1)	5						CTTTTCGCCACGGCCCGGGAA	0.721000													4	35					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149754329	149754329	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr5:149754329G>A	ENST00000451292.1	+	9	1341	c.1233G>A	c.(1231-1233)caG>caA	p.Q411Q	TCOF1_ENST00000513346.1_Silent_p.Q411Q|TCOF1_ENST00000504761.2_Silent_p.Q411Q|TCOF1_ENST00000394269.3_Silent_p.Q411Q|TCOF1_ENST00000377797.3_Silent_p.Q411Q|TCOF1_ENST00000439160.2_Silent_p.Q411Q|TCOF1_ENST00000445265.2_Silent_p.Q334Q|TCOF1_ENST00000323668.7_Silent_p.Q334Q			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	411					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGACTCGCAGAGCAGCAGCG	0.677000													7	21					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38502594	38502594	+	Missense_Mutation	SNP	C	C	T	rs147284975		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:38502594C>T	ENST00000356264.2	-	10	1084	c.869G>A	c.(868-870)cGg>cAg	p.R290Q	AMPH_ENST00000325590.5_Missense_Mutation_p.R290Q|AMPH_ENST00000428293.2_Missense_Mutation_p.R290Q	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	290					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TGACCGAGGCCGTGCTGGTGC	0.552000													28	81					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66638908	66638908	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:66638908G>C	ENST00000393960.1	-	6	646	c.365C>G	c.(364-366)tCt>tGt	p.S122C	PC_ENST00000393955.2_Missense_Mutation_p.S122C|PC_ENST00000393958.2_Missense_Mutation_p.S122C|PC_ENST00000355677.3_Missense_Mutation_p.S122C|PC_ENST00000524491.1_Missense_Mutation_p.S82C	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	122	Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CGCTCGCTCAGAGAGGAACCC	0.632000													28	113					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47156636	47156636	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:47156636C>G	ENST00000562435.1	-	6	970	c.586G>C	c.(586-588)Gag>Cag	p.E196Q	NETO2_ENST00000303155.5_Missense_Mutation_p.E189Q	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	196	CUB 2.					integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				GTTTTCTCCTCTTGTTCTACC	0.438000										HNSCC(25;0.065)			45	131					0	0	1	0	0
STEAP2-AS1	100874100	broad.mit.edu	37	7	89749009	89749009	+	RNA	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:89749009G>A	ENST00000478318.2	-	0	424				RP5-1121E10.2_ENST00000471553.1_lincRNA|DPY19L2P4_ENST00000497063.1_RNA																							AGGTCCTTCCGGCGGAGGATC	0.642000													5	19					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086695	39086695	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr21:39086695C>T	ENST00000400482.3	-	3	1354	c.765G>A	c.(763-765)ttG>ttA	p.L255L	KCNJ6_ENST00000288309.6_Silent_p.L255L	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	255					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CCGTCTGGTTCAACGGGATGA	0.502000													31	101					0	0	1	0	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31850333	31850333	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:31850333C>T	ENST00000397525.1	-	10	1532	c.1309G>A	c.(1309-1311)Gag>Aag	p.E437K	RP11-247I13.11_ENST00000464523.1_RNA|EIF4ENIF1_ENST00000382180.2_Missense_Mutation_p.E116K|EIF4ENIF1_ENST00000344710.5_Missense_Mutation_p.E274K|EIF4ENIF1_ENST00000330125.5_Missense_Mutation_p.E437K|EIF4ENIF1_ENST00000397523.1_Missense_Mutation_p.E437K	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	437						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GCTTCTACCTCCTCCACTGAA	0.463000													15	62					0	0	1	0	0
KRT19P2	160313	broad.mit.edu	37	12	95228661	95228661	+	RNA	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:95228661G>C	ENST00000405395.2	+	0	432					NR_036685.1																						GCACCCTCCAGGGTCTTGAGA	0.567000													5	4					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42827747	42827747	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:42827747C>T	ENST00000301204.3	+	14	1248	c.1207C>T	c.(1207-1209)Cca>Tca	p.P403S		NM_173633.2	NP_775904.2	Q8NBT3	TM145_HUMAN	transmembrane protein 145	403						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				CATGACCCGCCCATCAGCGGC	0.627000													12	40					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112622357	112622357	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr12:112622357G>A	ENST00000550722.1	-	61	10370	c.9975C>T	c.(9973-9975)gtC>gtT	p.V3325V	HECTD4_ENST00000430131.2_Silent_p.V3049V|HECTD4_ENST00000377560.5_Silent_p.V3299V	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGGACGTGCTGACCTCCATGC	0.632000													12	30					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119054012	119054012	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:119054012G>A	ENST00000409109.1	+	10	3379	c.2792G>A	c.(2791-2793)cGa>cAa	p.R931Q	NLRX1_ENST00000409265.4_Intron|NLRX1_ENST00000292199.2_Missense_Mutation_p.R931Q|NLRX1_ENST00000525863.1_Intron|NLRX1_ENST00000409991.1_Missense_Mutation_p.R931Q|NLRX1_ENST00000469103.2_3'UTR			Q86UT6	NLRX1_HUMAN	NLR family member X1	931	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CGGGTTCAGCGACACCTTGAG	0.612000													23	83					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73046445	73046445	+	Splice_Site	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:73046445G>A	ENST00000335350.6	+	5	968		c.e5-1		UNC5B_ENST00000373192.4_Splice_Site	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)						apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CACTCTTGCAGGTGGAATGGC	0.582000													7	160					0	0	1	0	0
KIF11	3832	broad.mit.edu	37	10	94405303	94405303	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:94405303G>A	ENST00000260731.3	+	18	2541	c.2451G>A	c.(2449-2451)caG>caA	p.Q817Q		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	817					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGACTGAACAGAGATGTGAAT	0.353000													20	77					0	0	1	0	0
HM13	81502	broad.mit.edu	37	20	30155980	30155980	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr20:30155980G>A	ENST00000335574.5	+	12	1258	c.1134G>A	c.(1132-1134)caG>caA	p.Q378Q	HM13_ENST00000376127.3_Intron|HM13_ENST00000492709.1_Intron|HM13_ENST00000398174.3_Silent_p.Q378Q|HM13-AS1_ENST00000412178.1_RNA|HM13_ENST00000340852.5_Intron	NM_178580.1	NP_848695.1	Q8TCT9	HM13_HUMAN	histocompatibility (minor) 13	374					membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			CCATGCAGCAGAAGCTAGCTG	0.701000													7	29					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189060730	189060730	+	Silent	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:189060730G>C	ENST00000332517.3	+	1	158	c.18G>C	c.(16-18)ctG>ctC	p.L6L		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	6					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CAGCAGATCTGATGGAGAACC	0.507000													29	127					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130488558	130488558	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:130488558C>T	ENST00000373289.3	+	10	1380	c.1300C>T	c.(1300-1302)Cgg>Tgg	p.R434W	TTC16_ENST00000393748.4_3'UTR|TTC16_ENST00000489226.1_3'UTR	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	434							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						CACGGCCATCCGGCACAACCC	0.607000													31	41					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113522114	113522114	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:113522114C>T	ENST00000284601.3	-	3	1014	c.946G>A	c.(946-948)Gaa>Aaa	p.E316K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	316					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AATTCTTTTTCATTATGTTCA	0.373000													28	100					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38158095	38158095	+	Silent	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:38158095C>G	ENST00000308059.6	+	28	4029	c.4008C>G	c.(4006-4008)ctC>ctG	p.L1336L	DLEC1_ENST00000452631.2_Silent_p.L1339L|DLEC1_ENST00000346219.3_Silent_p.L1336L			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	1336					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GCTGCCTCCTCTGGTCCCCAG	0.632000													25	108					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238256999	238256999	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:238256999C>T	ENST00000295550.4	-	30	7411	c.6959G>A	c.(6958-6960)gGa>gAa	p.G2320E	COL6A3_ENST00000353578.4_Missense_Mutation_p.G2114E|COL6A3_ENST00000347401.3_Missense_Mutation_p.G2119E|COL6A3_ENST00000346358.4_Missense_Mutation_p.G2120E|COL6A3_ENST00000472056.1_Missense_Mutation_p.G1713E|COL6A3_ENST00000409809.1_Missense_Mutation_p.G2114E	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2320	Collagen-like 5.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TACCTTTGGTCCTGGGTATCC	0.363000													36	169					0	0	1	0	0
GFOD2	81577	broad.mit.edu	37	16	67709387	67709387	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:67709387C>G	ENST00000268797.7	-	3	1174	c.829G>C	c.(829-831)Gag>Cag	p.E277Q	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	277						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		AGCAGCTCCTCTTGCGTGGCA	0.637000													23	53					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42793500	42793500	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr19:42793500G>A	ENST00000572681.2	+	9	4097	c.4029G>A	c.(4027-4029)atG>atA	p.M1343I	CIC_ENST00000575354.2_Missense_Mutation_p.M434I|CIC_ENST00000160740.3_Missense_Mutation_p.M434I			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GTGAGGACATGACGAGTGATG	0.632000			"""Mis, F, S"""		oligodendroglioma								12	35					0	0	1	0	0
STAM2	10254	broad.mit.edu	37	2	152992035	152992035	+	Missense_Mutation	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:152992035C>T	ENST00000263904.4	-	8	1136	c.787G>A	c.(787-789)Gag>Aag	p.E263K		NM_005843.4	NP_005834.4	O75886	STAM2_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	263					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)	16				BRCA - Breast invasive adenocarcinoma(221;0.22)		GCCTCAGTCTCTATGTTTAAA	0.318000													50	126					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36124944	36124944	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr22:36124944G>A	ENST00000249044.2	+	4	1301	c.1301G>A	c.(1300-1302)tGa>tAa	p.*434*		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	0					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						CACCGACAATGAGAAGAGGTA	0.602000													9	31					0	0	1	0	0
HRASLS	57110	broad.mit.edu	37	3	192973554	192973554	+	Missense_Mutation	SNP	T	T	G	rs137964301		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:192973554T>G	ENST00000264735.2	+	2	524	c.430T>G	c.(430-432)Tac>Gac	p.Y144D	HRASLS_ENST00000602513.1_Missense_Mutation_p.Y39D	NM_020386.4	NP_065119.2	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	39										breast(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)	10	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		GGGTGATGGTTACGTTATCAA	0.483000													53	184					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135204702	135204702	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:135204702C>T	ENST00000372169.2	-	10	2465	c.2283G>A	c.(2281-2283)tcG>tcA	p.S761S	SETX_ENST00000224140.5_Silent_p.S761S|SETX_ENST00000393220.1_Silent_p.S761S			Q7Z333	SETX_HUMAN	senataxin	761					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AATCTTCATTCGATGTGGACA	0.368000													5	238					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33760037	33760037	+	Silent	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr13:33760037C>A	ENST00000255486.4	-	1	179	c.123G>T	c.(121-123)gtG>gtT	p.V41V	STARD13_ENST00000336934.5_Intron|STARD13_ENST00000487412.1_Intron|STARD13_ENST00000399365.3_Intron	NM_178007.2	NP_821075.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	910					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		ATGTGTGGTTCACTCTGCTTT	0.517000													17	71					6.94344e-10	7.18015e-10	1	1	0
ZNF513	130557	broad.mit.edu	37	2	27600565	27600565	+	Missense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:27600565C>A	ENST00000323703.6	-	4	1671	c.1473G>T	c.(1471-1473)caG>caT	p.Q491H	ZNF513_ENST00000407879.1_Missense_Mutation_p.Q429H	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	491					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATGCACCTTCTGGTGGCGCT	0.647000													32	143					6.02846e-25	6.60951e-25	1	1	0
PCNT	5116	broad.mit.edu	37	21	47848407	47848407	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr21:47848407G>A	ENST00000359568.5	+	35	7700	c.7593G>A	c.(7591-7593)acG>acA	p.T2531T	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2531					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					TGCGCATGACGCACCTGCAGA	0.672000													14	32					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158255200	158255200	+	Silent	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:158255200C>A	ENST00000296526.7	+	9	1519	c.1194C>A	c.(1192-1194)acC>acA	p.T398T	GRIA2_ENST00000393815.2_Silent_p.T351T|GRIA2_ENST00000449365.1_Silent_p.T351T|GRIA2_ENST00000264426.9_Silent_p.T398T|GRIA2_ENST00000507898.1_Silent_p.T351T	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	398					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TGGTTGTTACCCTTACTGAGC	0.403000													35	149					3.38236e-24	3.69353e-24	1	1	0
PTH1R	5745	broad.mit.edu	37	3	46939346	46939346	+	Splice_Site	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:46939346G>A	ENST00000449590.1	+	6	518	c.313_splice	c.e6-1	p.G105_splice	PTH1R_ENST00000430002.2_Splice_Site_p.G105_splice|PTH1R_ENST00000418619.1_Splice_Site_p.G105_splice|PTH1R_ENST00000490109.1_3'UTR|PTH1R_ENST00000313049.5_Splice_Site_p.G105_splice	NM_000316.2	NP_000307.1	Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	105						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						TGGGCACAGGGCGCCCCTGTC	0.557000													9	23					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58139360	58139360	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:58139360G>A	ENST00000295956.4	+	39	6791	c.6626G>A	c.(6625-6627)gGa>gAa	p.G2209E	FLNB_ENST00000429972.2_Missense_Mutation_p.G2198E|FLNB_ENST00000490882.1_Missense_Mutation_p.G2240E|FLNB_ENST00000358537.3_Missense_Mutation_p.G2185E|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000348383.5_Missense_Mutation_p.G2168E|FLNB_ENST00000419752.2_Missense_Mutation_p.G2029E|FLNB_ENST00000493452.1_Missense_Mutation_p.G2016E	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2209	Interaction with FLNA 1.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGAGAAGCGGGAGTCCCAGGT	0.602000													9	31					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154022616	154022616	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:154022616C>G	ENST00000496811.1	-	8	1194	c.1114G>C	c.(1114-1116)Gaa>Caa	p.E372Q	DHX36_ENST00000544526.1_Missense_Mutation_p.E372Q|DHX36_ENST00000308361.6_Missense_Mutation_p.E372Q|DHX36_ENST00000329463.5_Missense_Mutation_p.E372Q	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	372	Helicase ATP-binding.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GAAAACTTTTCTGCATTCAAT	0.279000													26	129					0	0	1	0	0
FANCF	2188	broad.mit.edu	37	11	22646608	22646608	+	Missense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:22646608G>T	ENST00000327470.3	-	1	779	c.749C>A	c.(748-750)gCc>gAc	p.A250D		NM_022725.3	NP_073562.1	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	250					DNA repair	nucleoplasm	protein binding			kidney(3)|large_intestine(3)|lung(6)|skin(1)	13						GCGACAAAAGGCAGCAAAGAC	0.577000			"""N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia		OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	114					5.34276e-22	5.81104e-22	1	1	0
KIF11	3832	broad.mit.edu	37	10	94405326	94405326	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:94405326G>C	ENST00000260731.3	+	18	2564	c.2474G>C	c.(2473-2475)aGa>aCa	p.R825T		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	825					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTGAACACAAGAACAGTTTAT	0.353000													22	64					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169791937	169791937	+	Splice_Site	SNP	T	T	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:169791937T>C	ENST00000263817.6	-	23	2939		c.e23-2			NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11						bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ATTTGTAATCTGAAGATTGAA	0.453000													56	198					0	0	1	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125232130	125232130	+	RNA	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:125232130G>C	ENST00000439075.1	-	0	2615					NR_026876.1																						CCATTTTTTAGAATAAAAGAA	0.308000													12	45					0	0	1	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239307468	239307468	+	Missense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:239307468G>T	ENST00000373327.4	+	17	2206	c.1984G>T	c.(1984-1986)Gac>Tac	p.D662Y	TRAF3IP1_ENST00000391994.2_Missense_Mutation_p.D662Y|TRAF3IP1_ENST00000391993.3_Missense_Mutation_p.D596Y	NM_015650.3	NP_056465.2	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting protein 1	662	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(2)	23		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		AGACCAGCAAGACAAGATCTG	0.473000													57	64					2.82306e-37	3.12023e-37	1	1	0
RNF213	57674	broad.mit.edu	37	17	78247078	78247078	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:78247078G>A	ENST00000582970.1	+	3	279	c.136G>A	c.(136-138)Gag>Aag	p.E46K	RNF213_ENST00000508628.2_Missense_Mutation_p.E46K|RNF213_ENST00000319921.4_Missense_Mutation_p.E46K|RNF213_ENST00000456466.1_Missense_Mutation_p.E46K	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	46										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTCGGCCTCGGAGGGTGAAAT	0.547000													21	80					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228403320	228403320	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:228403320G>A	ENST00000570156.2	+	6	1959	c.1885G>A	c.(1885-1887)Gag>Aag	p.E629K	OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.E629K|OBSCN_ENST00000422127.1_Missense_Mutation_p.E629K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	629	Ig-like 6.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGAGGGTGGCGAGGTCACTTT	0.662000													9	11					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148463720	148463720	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr4:148463720C>G	ENST00000324300.5	+	8	1749	c.1234C>G	c.(1234-1236)Caa>Gaa	p.Q412E	EDNRA_ENST00000339690.5_3'UTR|EDNRA_ENST00000506066.1_Missense_Mutation_p.Q303E|EDNRA_ENST00000503721.1_3'UTR|EDNRA_ENST00000358556.4_Missense_Mutation_p.Q303E|EDNRA_ENST00000511804.1_Missense_Mutation_p.Q187E	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	412					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	GAACCACGATCAAAACAACCA	0.517000													16	70					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53560365	53560365	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:53560365G>C	ENST00000342160.3	-	83	13487	c.13030C>G	c.(13030-13032)Cag>Gag	p.Q4344E	HUWE1_ENST00000262854.6_Missense_Mutation_p.Q4344E			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4344	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AGATCCAGCTGATTAAAACTA	0.512000													5	24					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44945403	44945403	+	Missense_Mutation	SNP	G	G	C			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:44945403G>C	ENST00000296125.4	+	9	1067	c.999G>C	c.(997-999)tgG>tgC	p.W333C		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	333					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CGGATGCCTGGATGAAGCGAC	0.607000													37	186					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61929272	61929272	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr20:61929272C>T	ENST00000422202.1	+	2	161	c.93C>T	c.(91-93)ctC>ctT	p.L31L	COL20A1_ENST00000326996.6_Silent_p.L31L|COL20A1_ENST00000358894.6_Silent_p.L31L|COL20A1_ENST00000435874.1_Silent_p.L31L			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	31	Fibronectin type-III 1.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CAAGCGGTCTCCTGAGGCTGG	0.617000													6	27					0	0	1	0	0
RPL11	6135	broad.mit.edu	37	1	24019119	24019119	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:24019119G>A	ENST00000374550.3	+	2	72	c.27G>A	c.(25-27)gaG>gaA	p.E9E	RPL11_ENST00000482370.1_3'UTR	NM_000975.3|NM_001199802.1	NP_000966.2|NP_001186731.1	P62913	RL11_HUMAN	ribosomal protein L11	9					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		GTGAAAAGGAGAACCCCATGC	0.522000													28	111					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129520070	129520070	+	Missense_Mutation	SNP	G	G	A	rs140992502		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr5:129520070G>A	ENST00000305031.4	+	3	1593	c.1235G>A	c.(1234-1236)cGc>cAc	p.R412H	CHSY3_ENST00000507545.1_3'UTR	NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	412						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		ATGCTCAGCCGCAAAATTTCT	0.478000													21	78					0	0	1	0	0
CLIP2	7461	broad.mit.edu	37	7	73752876	73752876	+	Missense_Mutation	SNP	G	G	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:73752876G>T	ENST00000223398.6	+	3	547	c.220G>T	c.(220-222)Gac>Tac	p.D74Y	CLIP2_ENST00000361545.5_Missense_Mutation_p.D74Y|CLIP2_ENST00000395060.1_Missense_Mutation_p.D74Y	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	74						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						AGTGGGGGATGACTTCCTGGG	0.677000													4	14					0.00909568	0.00916281	1	1	0
PRSS23	11098	broad.mit.edu	37	11	86519137	86519137	+	Nonsense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:86519137C>G	ENST00000280258.5	+	2	877	c.452C>G	c.(451-453)tCa>tGa	p.S151*	PRSS23_ENST00000441050.1_Nonsense_Mutation_p.S119*|PRSS23_ENST00000533902.2_Intron	NM_007173.4	NP_009104.1	O95084	PRS23_HUMAN	protease, serine, 23	151					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TACCCTTTCTCAACATCAGTG	0.512000													25	89					0	0	1	0	0
TMEM255A	55026	broad.mit.edu	37	X	119427904	119427904	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:119427904G>A	ENST00000371369.4	-	3	430	c.204C>T	c.(202-204)ctC>ctT	p.L68L	TMEM255A_ENST00000309720.5_Silent_p.L68L|TMEM255A_ENST00000440464.1_Silent_p.L68L	NM_001104544.1	NP_001098014.1			transmembrane protein 255A																		ATCCAAAGCCGAGCTGCAAAG	0.403000													28	92					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1780271	1780271	+	Missense_Mutation	SNP	C	C	G			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:1780271C>G	ENST00000236671.2	-	4	531	c.399G>C	c.(397-399)aaG>aaC	p.K133N	RP11-295K3.1_ENST00000427721.1_Missense_Mutation_p.R4T	NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	133					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGGTACCATTCTTCACGTAGG	0.642000													95	168					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111864234	111864234	+	Silent	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr11:111864234G>A	ENST00000440460.2	+	14	1581	c.1284G>A	c.(1282-1284)caG>caA	p.Q428Q	DIXDC1_ENST00000389821.4_3'UTR|DIXDC1_ENST00000315253.5_Silent_p.Q217Q	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	429					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		AGCTGGGGCAGAAGGATCGCC	0.483000													15	59					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	152991459	152991459	+	Silent	SNP	C	C	T			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chrX:152991459C>T	ENST00000218104.3	+	1	1137	c.738C>T	c.(736-738)atC>atT	p.I246I	ABCD1_ENST00000370129.4_Silent_p.I61I	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	246	ABC transmembrane type-1.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTCGGCCATCGCCGGCCTCG	0.706000													10	28					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248570073	248570073	+	Missense_Mutation	SNP	C	C	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr1:248570073C>A	ENST00000366474.1	+	1	778	c.778C>A	c.(778-780)Cct>Act	p.P260T		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTGCTGATTCCTTTCTCTGT	0.507000													24	111					5.35356e-11	5.57833e-11	1	1	0
XIRP2	129446	broad.mit.edu	37	2	167760256	167760256	+	Missense_Mutation	SNP	G	G	T	rs140208720		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr2:167760256G>T	ENST00000409195.1	+	2	353	c.264G>T	c.(262-264)agG>agT	p.R88S	XIRP2_ENST00000409728.1_Missense_Mutation_p.R88S|XIRP2_ENST00000409043.1_Missense_Mutation_p.R88S|XIRP2_ENST00000295237.9_Missense_Mutation_p.R88S|XIRP2_ENST00000420519.1_Missense_Mutation_p.R88S|XIRP2_ENST00000409756.2_Missense_Mutation_p.R88S	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding	p.R88R(2)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACAACACCAGGGAATATGGTC	0.512000													20	57					3.51602e-12	3.69182e-12	1	1	0
ZKSCAN5	23660	broad.mit.edu	37	7	99129384	99129384	+	Missense_Mutation	SNP	G	G	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr7:99129384G>A	ENST00000394170.2	+	7	2283	c.2032G>A	c.(2032-2034)Gaa>Aaa	p.E678K	ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.E678K|ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.E678K	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	678					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TAGCCTAATTGAACATCAGGT	0.443000													34	125					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128781086	128781086	+	Frame_Shift_Del	DEL	G	G	-			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr3:128781086delG	ENST00000307395.4	+	3	726	c.504delG	c.(502-504)ctfs	p.L169fs		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	169					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	TGGCTGGCCTGCTGTGTGCCA	0.721													2	4	---	---	---	---					
KDM1B	221656	broad.mit.edu	37	6	18163094	18163094	+	Frame_Shift_Del	DEL	T	T	-			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr6:18163094delT	ENST00000388870.2	+	5	485	c.244delT	c.(244-246)ggfs	p.W82fs	KDM1B_ENST00000546309.2_Intron|KDM1B_ENST00000397244.1_Frame_Shift_Del_p.W82fs|KDM1B_ENST00000297792.5_Frame_Shift_Del_p.W82fs			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	82					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						CACCTCCCGATGGTATCATCT	0.378													27	107	---	---	---	---					
CNTNAP3B	728577	broad.mit.edu	37	9	43844265	43844265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr9:43844265delG	ENST00000377564.3	+	10	1992	c.1599delG	c.(1597-1599)gcfs	p.A533fs		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	533	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCAGGGGGCGCTGGGGAGTT	0.542													3	6	---	---	---	---					
MYOF	26509	broad.mit.edu	37	10	95159223	95159233	+	Frame_Shift_Del	DEL	CCTTTACTGTC	CCTTTACTGTC	-			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr10:95159223_95159233delCCTTTACTGTC	ENST00000371501.4	-	13	1259_1269	c.1137_1147delGACAGTAAAGG	c.(1135-1149)caaafs	p.QTVKE379fs	MYOF_ENST00000358334.5_Frame_Shift_Del_p.QTVKE379fs|MYOF_ENST00000359263.4_Frame_Shift_Del_p.QTVKE379fs|MYOF_ENST00000371489.1_Frame_Shift_Del_p.QTVKE379fs|MYOF_ENST00000371502.4_Frame_Shift_Del_p.QTVKE379fs			Q9NZM1	MYOF_HUMAN	myoferlin	379	C2 3.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CCAAATATTTCCTTTACTGTCTGTGAGAAGG	0.341													9	61	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372914	74372915	+	RNA	INS	-	-	T	rs67181940		TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr16:74372914_74372915insT	ENST00000429810.2	-	0	1404																											AACGTAGtttgttttttttttt	0.436													2	4	---	---	---	---					
RP11-1094M14.11	0	broad.mit.edu	37	17	33900514	33900515	+	RNA	INS	-	-	A			TCGA-T2-A6WX-01A-12D-A34J-08	TCGA-T2-A6WX-10B-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7098cee0-5b96-4279-83ab-a469bdf77237	c47cb327-1204-4ba6-9525-36f5f5113599	g.chr17:33900514_33900515insA	ENST00000592381.1	+	0	382																											gaccctgtcttaaaaaaaaaaa	0.411													2	4	---	---	---	---					
