Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF37A	7587	broad.mit.edu	37	10	38407123	38407123	+	Silent	SNP	G	G	A	rs149714320	byFrequency	TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:38407123G>A	ENST00000351773.3	+	8	1874	c.1044G>A	c.(1042-1044)acG>acA	p.T348T	ZNF37A_ENST00000361085.4_Silent_p.T348T	NM_001007094.2	NP_001007095.1	P17032	ZN37A_HUMAN	zinc finger protein 37A	348						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						ATCAAAGAACGCACACAGGGG	0.413000													24	81					0	0	1	0	0
LONRF2	164832	broad.mit.edu	37	2	100912016	100912016	+	Splice_Site	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:100912016C>T	ENST00000393437.3	-	8	2116		c.e8-1		LONRF2_ENST00000409647.1_Splice_Site	NM_198461.3	NP_940863.3	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger 2						proteolysis		ATP-dependent peptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	34						TTGCCAATAACTGTAACAAAA	0.378000													46	50					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49640025	49640025	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:49640025C>T	ENST00000334186.4	+	15	2059	c.1710C>T	c.(1708-1710)ttC>ttT	p.F570F	PPFIA3_ENST00000602351.1_Silent_p.F570F	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	570						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CACCCCCATTCCCTGGGGAAC	0.667000													4	9					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590520	156590520	+	Silent	SNP	C	C	A	rs144904764	by1000genomes	TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:156590520C>A	ENST00000302938.4	-	2	851	c.756G>T	c.(754-756)acG>acT	p.T252T		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	252	Ala-rich.					nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGGAGTGCTCGTGGATGGAG	0.577000													57	51					1.03172e-35	1.15886e-35	1	1	0
CHD9	80205	broad.mit.edu	37	16	53338091	53338091	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:53338091C>G	ENST00000566029.1	+	31	6382	c.6173C>G	c.(6172-6174)tCt>tGt	p.S2058C	CHD9_ENST00000447540.1_Missense_Mutation_p.S2058C|CHD9_ENST00000564845.1_Missense_Mutation_p.S2058C|CHD9_ENST00000398510.3_Missense_Mutation_p.S2058C			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2058					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GAGCCTCAGTCTTCTGAAGAA	0.413000													11	19					0	0	1	0	0
AGMO	392636	broad.mit.edu	37	7	15405151	15405151	+	Silent	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:15405151T>A	ENST00000342526.3	-	12	1420	c.1251A>T	c.(1249-1251)tcA>tcT	p.S417S		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	417					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						CAAAAGCAGATGACAATGAAG	0.403000													10	20					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135251303	135251303	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr9:135251303C>T	ENST00000334270.2	-	11	2756	c.2717G>A	c.(2716-2718)tGa>tAa	p.*906*	TTF1_ENST00000461970.1_5'UTR	NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	0					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ctcctgacctcagatgatcca	0.507000													5	11					0	0	1	0	0
KPNB1	3837	broad.mit.edu	37	17	45742519	45742519	+	Missense_Mutation	SNP	A	A	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:45742519A>C	ENST00000290158.4	+	9	1401	c.994A>C	c.(994-996)Aaa>Caa	p.K332Q	KPNB1_ENST00000540627.1_Missense_Mutation_p.K187Q|KPNB1_ENST00000537679.1_Intron|KPNB1_ENST00000535458.2_Missense_Mutation_p.K187Q	NM_001276453.1|NM_002265.4	NP_001263382.1|NP_002256.2	Q14974	IMB1_HUMAN	karyopherin (importin) beta 1	332	IAB-binding.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			breast(1)|ovary(1)|pancreas(1)|skin(1)	4						GACACTAACTAAACAGGTGAG	0.473000													9	27					0	0	1	0	0
FBXO41	150726	broad.mit.edu	37	2	73492558	73492558	+	Silent	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:73492558G>T	ENST00000521871.1	-	5	1831	c.1416C>A	c.(1414-1416)cgC>cgA	p.R472R	FBXO41_ENST00000295133.5_Silent_p.R533R|FBXO41_ENST00000520530.2_Silent_p.R472R			Q8TF61	FBX41_HUMAN	F-box protein 41	472						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						GGCGGGGTCTGCGCTGCCAGT	0.701000													19	17					5.35267e-07	5.51557e-07	1	1	0
DNTTIP2	30836	broad.mit.edu	37	1	94342497	94342497	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:94342497G>A	ENST00000436063.2	-	2	1051	c.994C>T	c.(994-996)Caa>Taa	p.Q332*	DNTTIP2_ENST00000460191.1_5'UTR	NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		ACTAACTGTTGAAGGCTAGTG	0.378000													12	40					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41767894	41767894	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr13:41767894C>T	ENST00000379483.3	-	1	808	c.500G>A	c.(499-501)cGt>cAt	p.R167H		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	167							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		CAGGTCAAGACGTCGGGCTAA	0.567000													23	62					0	0	1	0	0
TMEM186	25880	broad.mit.edu	37	16	8890157	8890157	+	Silent	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:8890157G>T	ENST00000333050.6	-	2	327	c.294C>A	c.(292-294)ctC>ctA	p.L98L	PMM2_ENST00000566983.1_Intron|TMEM186_ENST00000564869.1_Intron	NM_015421.3	NP_056236.2	Q96B77	TM186_HUMAN	transmembrane protein 186	98						integral to membrane|mitochondrion				NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9						TGTTGAGAGTGAGGAGGCCCT	0.537000													19	32					1.67942e-08	1.76116e-08	1	1	0
TMEM91	641649	broad.mit.edu	37	19	41889762	41889762	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:41889762C>A	ENST00000392002.2	+	4	1163	c.503C>A	c.(502-504)tCc>tAc	p.S168Y	TMEM91_ENST00000356385.4_3'UTR|TMEM91_ENST00000604123.1_Intron|BCKDHA_ENST00000595085.1_Intron|TMEM91_ENST00000447302.2_Intron|CTC-435M10.3_ENST00000540732.1_Intron|TMEM91_ENST00000413014.2_Intron|TMEM91_ENST00000542945.1_3'UTR|TMEM91_ENST00000539627.1_3'UTR|TMEM91_ENST00000436170.2_Intron|TMEM91_ENST00000544232.1_Intron	NM_001098821.1	NP_001092291.1			transmembrane protein 91											lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	5						TACCTTGCCTCCCGAGACCCG	0.672000													10	25					1.33987e-11	1.44341e-11	1	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140731304	140731304	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:140731304G>A	ENST00000523390.1	+	1	1477	c.1477G>A	c.(1477-1479)Gag>Aag	p.E493K	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGACCTGGAGCCGCGGGA	0.647000													51	60					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177033996	177033996	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:177033996C>T	ENST00000468418.3	+	3	2244	c.154C>T	c.(154-156)Ccc>Tcc	p.P52S	HOXD3_ENST00000410016.1_Missense_Mutation_p.P52S|HOXD3_ENST00000249440.3_Missense_Mutation_p.P52S			P31249	HXD3_HUMAN	homeobox D3	52					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GCCCTACCCACCCCCTGCTGC	0.587000													19	56					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46859976	46859976	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr22:46859976G>A	ENST00000262738.3	-	2	3810	c.3811C>T	c.(3811-3813)Cgc>Tgc	p.R1271C	CELSR1_ENST00000395964.1_Missense_Mutation_p.R1271C	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1271					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AACTGGCCGCGGACGCCGCCA	0.627000													23	79					0	0	1	0	0
FARSB	10056	broad.mit.edu	37	2	223504411	223504411	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:223504411C>A	ENST00000281828.6	-	5	606	c.343G>T	c.(343-345)Gct>Tct	p.A115S	FARSB_ENST00000536361.1_Missense_Mutation_p.A16S	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	115					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	CGTATCTTAGCTGTCTGAAAT	0.363000													22	13					4.35082e-09	4.60332e-09	1	1	0
GLG1	2734	broad.mit.edu	37	16	74526880	74526880	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:74526880C>T	ENST00000422840.2	-	7	1208	c.1209G>A	c.(1207-1209)atG>atA	p.M403I	GLG1_ENST00000205061.5_Missense_Mutation_p.M403I|GLG1_ENST00000447066.2_Missense_Mutation_p.M392I	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	403						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						ACTCCAGGCACATTAACAAGT	0.383000													19	46					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22680748	22680748	+	Missense_Mutation	SNP	T	T	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:22680748T>G	ENST00000333957.4	-	4	511	c.256A>C	c.(256-258)Att>Ctt	p.I86L	C2CD5_ENST00000536386.1_Missense_Mutation_p.I86L|C2CD5_ENST00000544930.1_5'UTR|C2CD5_ENST00000545552.1_Missense_Mutation_p.I86L|C2CD5_ENST00000542676.1_Missense_Mutation_p.I86L|C2CD5_ENST00000446597.1_Missense_Mutation_p.I86L|C2CD5_ENST00000396028.2_Missense_Mutation_p.I86L	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		ACTTTACCAATGGCATCATTT	0.363000													93	86					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43269995	43269995	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:43269995G>A	ENST00000372585.5	+	8	1214	c.1119G>A	c.(1117-1119)ctG>ctA	p.L373L	SLC22A7_ENST00000372574.3_Silent_p.L371L|SLC22A7_ENST00000372589.3_Silent_p.L371L	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	373						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GGCTGGGGCTGAACGTGTACC	0.597000													19	48					0	0	1	0	0
MAP3K2	10746	broad.mit.edu	37	2	128075777	128075777	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:128075777G>A	ENST00000409947.1	-	13	1444	c.1162C>T	c.(1162-1164)Caa>Taa	p.Q388*	MAP3K2_ENST00000344908.5_Nonsense_Mutation_p.Q388*			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	388	Protein kinase.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GGGTCAAATTGAACTTGCTTA	0.383000													32	126					0	0	1	0	0
ZNF672	79894	broad.mit.edu	37	1	249142661	249142661	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:249142661G>T	ENST00000306562.3	+	4	1934	c.1188G>T	c.(1186-1188)gaG>gaT	p.E396D		NM_024836.1	NP_079112.1	Q499Z4	ZN672_HUMAN	zinc finger protein 672	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)	5	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGCCAGCGGAGTGCGCAGAGT	0.677000													14	19					4.3838e-07	4.53695e-07	1	1	0
DNAJC14	85406	broad.mit.edu	37	12	56221719	56221719	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:56221719C>T	ENST00000357606.3	-	3	1013	c.724G>A	c.(724-726)Gag>Aag	p.E242K	DNAJC14_ENST00000317287.5_Missense_Mutation_p.E242K|DNAJC14_ENST00000317269.3_Missense_Mutation_p.E242K			Q6Y2X3	DJC14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 14	242					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						CATAGTTCCTCGGCTCCCCAC	0.557000													27	50					0	0	1	0	0
PML	5371	broad.mit.edu	37	15	74327717	74327717	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:74327717C>T	ENST00000268059.6	+	8	2011	c.1915C>T	c.(1915-1917)Cac>Tac	p.H639Y	PML_ENST00000569965.1_Intron|PML_ENST00000569477.1_3'UTR|PML_ENST00000564428.1_Intron|PML_ENST00000436891.3_3'UTR|PML_ENST00000354026.6_Missense_Mutation_p.H591Y|PML_ENST00000395132.2_Intron|PML_ENST00000395135.3_Intron|PML_ENST00000435786.2_3'UTR|PML_ENST00000359928.4_Intron|PML_ENST00000565898.1_Intron|PML_ENST00000268058.3_Intron|PML_ENST00000563500.1_3'UTR	NM_033239.2|NM_033244.3	NP_150242.1|NP_150247.2	P29590	PML_HUMAN	promyelocytic leukemia	36					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						TGCTGAGCCTCACAGCGAGCC	0.667000			T	"""RARA, PAX5"""	"""APL, ALL"""								54	63					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69263255	69263255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:69263255G>A	ENST00000551568.1	-	6	697	c.637C>T	c.(637-639)Cga>Tga	p.R213*	CPM_ENST00000338356.3_Nonsense_Mutation_p.R213*|CPM_ENST00000546373.1_Nonsense_Mutation_p.R213*	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	213					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GTTAAGCTTCGGGAGTATAAT	0.373000													34	54					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16890647	16890647	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:16890647C>T	ENST00000430580.2	-	29	4098	c.3211G>A	c.(3211-3213)Gaa>Aaa	p.E1071K		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	1051	NBPF 7.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGCAAGACTTCAGGCTCTTCC	0.463000													68	675					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28120136	28120136	+	Missense_Mutation	SNP	A	A	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:28120136A>T	ENST00000330236.6	+	5	933	c.749A>T	c.(748-750)gAa>gTa	p.E250V	ZKSCAN8_ENST00000457389.2_Missense_Mutation_p.E250V	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		AACAGGCCAGAAAATTTCAGA	0.393000													37	74					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136581548	136581548	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:136581548A>G	ENST00000264162.2	-	4	840	c.830T>C	c.(829-831)tTc>tCc	p.F277S		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	277	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GTTGAAGATGAAAACTTTCAC	0.473000													32	13					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45821664	45821664	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr21:45821664G>A	ENST00000397928.1	+	16	2867	c.2422G>A	c.(2422-2424)Gcc>Acc	p.A808T	TRPM2_ENST00000300482.5_Missense_Mutation_p.A808T|TRPM2_ENST00000397932.2_Missense_Mutation_p.A808T|TRPM2_ENST00000300481.9_Missense_Mutation_p.A788T|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	808						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CTCCTACTTCGCCTTCCTCTG	0.632000													129	47					0	0	1	0	0
IL7	3574	broad.mit.edu	37	8	79646064	79646064	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:79646064C>G	ENST00000263851.4	-	6	1018	c.418G>C	c.(418-420)Gaa>Caa	p.E140Q	IL7_ENST00000519833.1_Intron|IL7_ENST00000541183.1_Missense_Mutation_p.E27Q|IL7_ENST00000520269.1_Missense_Mutation_p.E96Q	NM_000880.3|NM_001199886.1|NM_001199887.1	NP_000871.1|NP_001186815.1|NP_001186816.1	P13232	IL7_HUMAN	interleukin 7	140					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding			endometrium(2)|large_intestine(2)|lung(1)	5						GATTTATTTTCTTCCTAGAGA	0.229000													12	73					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255239	140255239	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:140255239C>T	ENST00000398631.2	+	1	182	c.182C>T	c.(181-183)cCg>cTg	p.P61L	PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGGTGCCGCGCCTGTTC	0.612000													62	70					0	0	1	0	0
PML	5371	broad.mit.edu	37	15	74328064	74328064	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:74328064C>T	ENST00000268059.6	+	8	2358	c.2262C>T	c.(2260-2262)ttC>ttT	p.F754F	PML_ENST00000569965.1_Intron|PML_ENST00000564428.1_Intron|PML_ENST00000436891.3_3'UTR|PML_ENST00000354026.6_Silent_p.F706F|PML_ENST00000395132.2_Intron|PML_ENST00000395135.3_Intron|PML_ENST00000435786.2_3'UTR|PML_ENST00000359928.4_Intron|PML_ENST00000565898.1_Intron|PML_ENST00000268058.3_Intron|PML_ENST00000563500.1_3'UTR	NM_033239.2|NM_033244.3	NP_150242.1|NP_150247.2	P29590	PML_HUMAN	promyelocytic leukemia	0					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						CCCTCCCCTTCTCCTCCATGG	0.622000			T	"""RARA, PAX5"""	"""APL, ALL"""								45	70					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881810	228881810	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:228881810G>T	ENST00000392056.3	-	7	3806	c.3760C>A	c.(3760-3762)Ccc>Acc	p.P1254T	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P1254T	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1254						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTTTGATGGGCACATTCACT	0.567000													40	23					7.04047e-22	7.7609e-22	1	1	0
PEG3	5178	broad.mit.edu	37	19	57325583	57325583	+	Silent	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:57325583A>G	ENST00000326441.9	-	10	4590	c.4227T>C	c.(4225-4227)gcT>gcC	p.A1409A	ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Silent_p.A1409A|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000593695.1_Silent_p.A1283A|PEG3_ENST00000598410.1_Silent_p.A1285A	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1409	3 X 7 AA repeat of P-E-V-E-A-A-E.|Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTTCTGGCTCAGCAGCCTCCA	0.577000													5	82					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125281665	125281665	+	Silent	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr9:125281665A>G	ENST00000340750.1	+	1	246	c.246A>G	c.(244-246)ttA>ttG	p.L82L		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						CAAAGATGTTATTAAGCATGC	0.428000													75	161					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14270318	14270318	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:14270318C>G	ENST00000340736.6	-	11	2230	c.1933G>C	c.(1933-1935)Gtg>Ctg	p.V645L	CTB-55O6.12_ENST00000592086.1_RNA|CTB-55O6.12_ENST00000588387.1_RNA|LPHN1_ENST00000361434.3_Missense_Mutation_p.V640L	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	645					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCCGTGTGCACCTGCTCCGTG	0.637000													8	26					0	0	1	0	0
HERPUD2	64224	broad.mit.edu	37	7	35707179	35707179	+	Nonsense_Mutation	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:35707179G>C	ENST00000396081.1	-	4	1163	c.359C>G	c.(358-360)tCa>tGa	p.S120*	HERPUD2_ENST00000311350.3_Nonsense_Mutation_p.S120*|HERPUD2_ENST00000426180.1_5'UTR	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	120	Ser-rich.				response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						TGGAGTTGTTGATCCTGAATG	0.363000													5	94					0	0	1	0	0
ANKRD28	23243	broad.mit.edu	37	3	15720996	15720996	+	Missense_Mutation	SNP	A	A	C	rs116976698	by1000genomes	TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:15720996A>C	ENST00000399451.2	-	22	2741	c.2374T>G	c.(2374-2376)Ttg>Gtg	p.L792V	ANKRD28_ENST00000497037.1_5'UTR|ANKRD28_ENST00000383777.1_Missense_Mutation_p.L825V	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	792						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						GCACAATGCAATGGACTAAAA	0.383000													20	15					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26568407	26568407	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:26568407C>A	ENST00000381340.3	-	51	7551	c.7135G>T	c.(7135-7137)Gag>Tag	p.E2379*	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2379					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					AGCAAAGTCTCTTCCCTGTAC	0.363000													4	79					0.150653	0.150653	1	1	0
IMPDH1	3614	broad.mit.edu	37	7	128041099	128041099	+	Silent	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:128041099C>G	ENST00000338791.6	-	6	824	c.474G>C	c.(472-474)gtG>gtC	p.V158V	IMPDH1_ENST00000470772.1_Silent_p.V73V|IMPDH1_ENST00000480861.1_Silent_p.V73V|IMPDH1_ENST00000378717.4_Silent_p.V89V|IMPDH1_ENST00000419067.2_Silent_p.V125V|IMPDH1_ENST00000496200.1_Silent_p.V73V|IMPDH1_ENST00000354269.5_Silent_p.V148V|IMPDH1_ENST00000348127.6_Silent_p.V122V|IMPDH1_ENST00000343214.4_Silent_p.V73V	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	73	CBS 1.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CAGCCTCTGTCACAGTGTCCA	0.602000													20	38					0	0	1	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150027948	150027948	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:150027948A>G	ENST00000343855.4	+	1	1011	c.455A>G	c.(454-456)cAg>cGg	p.Q152R	LRRC61_ENST00000323078.7_Intron|LRRC61_ENST00000359623.4_Intron|LRRC61_ENST00000493307.1_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		GAGCCTCTGCAGAGCAGCAGC	0.682000													24	24					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113384607	113384607	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:113384607G>A	ENST00000228928.7	+	4	875	c.696G>A	c.(694-696)ctG>ctA	p.L232L	RP1-71H24.1_ENST00000552784.1_RNA|OAS3_ENST00000546638.1_3'UTR	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	232	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						TGGAATTGCTGACCATCTTCG	0.597000													12	27					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294592	124294592	+	Missense_Mutation	SNP	A	A	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:124294592A>T	ENST00000356130.3	-	1	197	c.176T>A	c.(175-177)aTg>aAg	p.M59K		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GAAAAAGTACATGGGGGTGTG	0.408000													39	12					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149200006	149200006	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:149200006C>A	ENST00000309241.5	+	2	121	c.89C>A	c.(88-90)tCc>tAc	p.S30Y	PPARGC1B_ENST00000360453.4_Missense_Mutation_p.S30Y|PPARGC1B_ENST00000403750.1_Missense_Mutation_p.S5Y|PPARGC1B_ENST00000394320.3_Missense_Mutation_p.S30Y	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	30	Abolishes DNA transcriptional activity when missing.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GGTGGAGGGTCCGGGGAGGAG	0.577000													19	57					2.39187e-15	2.60034e-15	1	1	0
LYL1	4066	broad.mit.edu	37	19	13210418	13210418	+	Silent	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:13210418C>G	ENST00000264824.4	-	4	918	c.558G>C	c.(556-558)ctG>ctC	p.L186L		NM_005583.4	NP_005574.2	P12980	LYL1_HUMAN	lymphoblastic leukemia derived sequence 1	186	Helix-loop-helix motif.				B cell differentiation|blood vessel maturation|definitive hemopoiesis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			cervix(1)|endometrium(2)|kidney(1)|lung(2)|prostate(1)	7			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)			CGTTCTTGCTCAGCTTCCGGT	0.677000			T	TRB@	T-ALL								3	8					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72190550	72190550	+	Silent	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:72190550A>G	ENST00000555818.1	+	16	4806	c.4458A>G	c.(4456-4458)ggA>ggG	p.G1486G	SIPA1L1_ENST00000358550.2_Silent_p.G1465G|SIPA1L1_ENST00000381232.3_Silent_p.G1465G|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000537413.1_Silent_p.G940G	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1486	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACCTGATTGGATGGAAAAAAC	0.502000													65	65					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148560	34148560	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrX:34148560G>A	ENST00000346193.3	-	1	1887	c.1836C>T	c.(1834-1836)ttC>ttT	p.F612F		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	612										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						CAGCCCACTTGAAGAATTCAC	0.428000													36	16					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9452476	9452476	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:9452476G>C	ENST00000379719.3	+	16	1949	c.1807G>C	c.(1807-1809)Gac>Cac	p.D603H	CTD-2371O3.2_ENST00000531111.1_RNA	NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	603					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		AGGTAGTGATGACAAAGCAGT	0.368000													25	11					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72858434	72858434	+	Silent	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:72858434G>T	ENST00000339594.4	-	17	4208	c.3870C>A	c.(3868-3870)ggC>ggA	p.G1290G	BAZ1B_ENST00000404251.1_Silent_p.G1290G	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1290					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				CGCTGTGCTTGCCCCGGATGG	0.572000													73	71					6.20995e-33	6.94226e-33	1	1	0
FRA10AC1	118924	broad.mit.edu	37	10	95459821	95459821	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:95459821C>T	ENST00000359204.4	-	2	240	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K	FRA10AC1_ENST00000371430.2_Missense_Mutation_p.E15K|FRA10AC1_ENST00000394100.2_Missense_Mutation_p.E15K|FRA10AC1_ENST00000536233.1_Missense_Mutation_p.E15K	NM_145246.4	NP_660289.2	Q70Z53	F10C1_HUMAN	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	15						nucleus	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|urinary_tract(1)	14						CCACAGCGTTCATCATCACTA	0.323000													25	40					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043061	184043061	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:184043061G>A	ENST00000342981.4	+	18	3278	c.2864G>A	c.(2863-2865)cGa>cAa	p.R955Q	EIF4G1_ENST00000427845.1_Missense_Mutation_p.R868Q|EIF4G1_ENST00000352767.3_Missense_Mutation_p.R961Q|EIF4G1_ENST00000392537.2_Missense_Mutation_p.R867Q|EIF4G1_ENST00000411531.1_Missense_Mutation_p.R915Q|EIF4G1_ENST00000382330.3_Missense_Mutation_p.R961Q|EIF4G1_ENST00000435046.2_Missense_Mutation_p.R758Q|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000350481.5_Missense_Mutation_p.R790Q|EIF4G1_ENST00000424196.1_Missense_Mutation_p.R961Q|EIF4G1_ENST00000319274.6_Missense_Mutation_p.R954Q|EIF4G1_ENST00000346169.2_Missense_Mutation_p.R954Q|EIF4G1_ENST00000434061.2_Missense_Mutation_p.R759Q|EIF4G1_ENST00000441154.1_Missense_Mutation_p.R791Q|EIF4G1_ENST00000414031.1_Missense_Mutation_p.R914Q	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	954	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCCTAGCCCCGAATGGATCAG	0.522000													25	121					0	0	1	0	0
GOLGA5	9950	broad.mit.edu	37	14	93263973	93263973	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:93263973C>T	ENST00000163416.2	+	2	447	c.191C>T	c.(190-192)tCa>tTa	p.S64L	GOLGA5_ENST00000355976.2_Missense_Mutation_p.S64L	NM_005113.2	NP_005104.2	Q8TBA6	GOGA5_HUMAN	golgin A5	64					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		ACGTATATTTCATCAGCAGCT	0.393000			T	RET	papillary thyroid								42	34					0	0	1	0	0
RTP4	64108	broad.mit.edu	37	3	187089114	187089114	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:187089114A>G	ENST00000259030.2	+	2	804	c.694A>G	c.(694-696)Att>Gtt	p.I232V		NM_022147.2	NP_071430.2	Q96DX8	RTP4_HUMAN	receptor (chemosensory) transporter protein 4	232					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CTGTGTCTTTATTTTGCTGCT	0.413000													27	42					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103405944	103405944	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:103405944C>A	ENST00000358392.2	-	43	3676	c.3359G>T	c.(3358-3360)gGt>gTt	p.G1120V	COL11A1_ENST00000512756.1_Missense_Mutation_p.G992V|COL11A1_ENST00000353414.4_Missense_Mutation_p.G1069V|COL11A1_ENST00000370096.3_Missense_Mutation_p.G1108V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1108	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCAACAGGACCTTGAACTCC	0.483000													16	19					3.41278e-10	3.64338e-10	1	1	0
RALGAPA1	253959	broad.mit.edu	37	14	36192260	36192260	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:36192260G>A	ENST00000258840.6	-	15	2467	c.2077C>T	c.(2077-2079)Cag>Tag	p.Q693*	RALGAPA1_ENST00000554704.1_5'UTR|RALGAPA1_ENST00000389698.3_Nonsense_Mutation_p.Q693*|RALGAPA1_ENST00000382366.3_Nonsense_Mutation_p.Q693*|RALGAPA1_ENST00000307138.6_Nonsense_Mutation_p.Q693*			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	693					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TTTTGTTTCTGTTCACTCAGC	0.343000													157	37					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149514780	149514780	+	RNA	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:149514780C>T	ENST00000378016.2	+	0	11322							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTCAGCCCCTCGGGCCTGGAG	0.652000													26	18					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72421485	72421485	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:72421485T>C	ENST00000359373.5	-	10	2212	c.1361A>G	c.(1360-1362)aAt>aGt	p.N454S	ARAP1_ENST00000429686.1_Missense_Mutation_p.N209S|ARAP1_ENST00000334211.8_Missense_Mutation_p.N209S|ARAP1_ENST00000455638.2_Missense_Mutation_p.N454S|ARAP1_ENST00000426523.1_Missense_Mutation_p.N209S|ARAP1_ENST00000393605.3_Missense_Mutation_p.N214S|ARAP1_ENST00000393609.3_Missense_Mutation_p.N454S			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	454	PH 2.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						GTACAGCTTATTCTTGAAGCC	0.607000													106	40					0	0	1	0	0
GNPAT	8443	broad.mit.edu	37	1	231377141	231377141	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:231377141C>T	ENST00000366647.4	+	1	186	c.17C>T	c.(16-18)tCa>tTa	p.S6L	GNPAT_ENST00000366646.3_Missense_Mutation_p.S6L	NM_014236.3	NP_055051.1	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	6	Poly-Ser.				ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	23	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TCTTCCAGTTCATCTAACTCT	0.622000													66	51					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57761261	57761261	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:57761261C>T	ENST00000269122.3	+	28	4623	c.4349C>T	c.(4348-4350)cCg>cTg	p.P1450L	CLTC_ENST00000393043.1_Missense_Mutation_p.P1450L|CLTC_ENST00000579456.1_Missense_Mutation_p.P387L	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1450	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CTGGTGAAACCGTATTTGCGT	0.328000			T	"""ALK, TFE3"""	"""ALCL, renal """								25	36					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151773897	151773897	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:151773897G>A	ENST00000368820.3	-	2	2221	c.1284C>T	c.(1282-1284)ggC>ggT	p.G428G		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	428	Ig-like C2-type.					integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCGCATGCCCGCCCTCCTCTG	0.612000													19	91					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8216345	8216345	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:8216345G>A	ENST00000361926.3	+	3	817	c.707G>A	c.(706-708)aGg>aAg	p.R236K	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.R236K	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	236					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						GAGGTCCCCAGGGTCCCCCGT	0.711000													68	28					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46472023	46472023	+	Missense_Mutation	SNP	A	A	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:46472023A>T	ENST00000361297.2	+	8	1141	c.858A>T	c.(856-858)gaA>gaT	p.E286D	MAST2_ENST00000372008.1_Missense_Mutation_p.E171D|MAST2_ENST00000372009.2_Missense_Mutation_p.E286D	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	286					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CAGATGAGGAAGGACGGCAGT	0.557000													35	89					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128814571	128814571	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr4:128814571G>A	ENST00000270861.5	+	11	2594	c.2320G>A	c.(2320-2322)Gag>Aag	p.E774K	PLK4_ENST00000507249.1_Missense_Mutation_p.E713K|PLK4_ENST00000513090.1_Missense_Mutation_p.E742K|PLK4_ENST00000514379.1_Missense_Mutation_p.E733K|PLK4_ENST00000515069.1_Missense_Mutation_p.E696K	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	774					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E774*(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						CCATGCTAATGAGGTACATAC	0.333000													32	14					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13941053	13941053	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:13941053C>T	ENST00000254323.2	+	13	2348	c.2159C>T	c.(2158-2160)aCa>aTa	p.T720I	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.T554I	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	720							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TCCTTATTCACACCAGTGGAG	0.617000													15	38					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169581536	169581536	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:169581536C>T	ENST00000263686.6	-	6	917	c.880G>A	c.(880-882)Gag>Aag	p.E294K	SELP_ENST00000367786.2_Missense_Mutation_p.E294K|SELP_ENST00000367794.2_Missense_Mutation_p.E294K|SELP_ENST00000458599.2_Missense_Mutation_p.E294K|SELP_ENST00000367792.2_Missense_Mutation_p.E294K|SELP_ENST00000367788.2_Intron|SELP_ENST00000367791.2_Missense_Mutation_p.E294K|SELP_ENST00000367793.2_Intron	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	294	Sushi 2.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GCAAATCCCTCTTCACAACTG	0.527000													40	32					0	0	1	0	0
EVI5L	115704	broad.mit.edu	37	19	7927297	7927297	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:7927297G>A	ENST00000270530.4	+	16	1987	c.1791G>A	c.(1789-1791)ctG>ctA	p.L597L	EVI5L_ENST00000538904.2_Silent_p.L608L	NM_145245.3	NP_660288.1	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like	597						intracellular	protein binding|Rab GTPase activator activity			breast(1)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	12						GCAACCTTCTGAACCGCGTGG	0.677000													11	20					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49442492	49442492	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:49442492G>A	ENST00000301067.7	-	13	4080	c.4081C>T	c.(4081-4083)Cag>Tag	p.Q1361*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		ACGGTATTCTGCATGGTGTCA	0.453000													118	168					0	0	1	0	0
DEFB128	245939	broad.mit.edu	37	20	168551	168551	+	Silent	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr20:168551G>T	ENST00000334391.4	-	2	315	c.258C>A	c.(256-258)ccC>ccA	p.P86P		NM_001037732.1	NP_001032821.1	Q7Z7B8	DB128_HUMAN	defensin, beta 128	86					defense response to bacterium	extracellular region				breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5		all_cancers(10;0.00499)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			TGGTGATGGTGGGTAAGATGA	0.433000													45	137					4.25531e-23	4.71266e-23	1	1	0
ASAH2	56624	broad.mit.edu	37	10	51970603	51970603	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:51970603C>G	ENST00000395526.3	-	11	1393	c.1394G>C	c.(1393-1395)gGa>gCa	p.G465A	ASAH2_ENST00000329428.6_Missense_Mutation_p.G411A|ASAH2_ENST00000447815.1_Missense_Mutation_p.G430A|ASAH2_ENST00000443575.1_Missense_Mutation_p.G307A	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	465					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						ATTGAGGCCTCCAACTCCATC	0.378000													41	121					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144993486	144993486	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:144993486G>A	ENST00000322810.4	-	32	11083	c.10914C>T	c.(10912-10914)gtC>gtT	p.V3638V	PLEC_ENST00000436759.2_Silent_p.V3528V|PLEC_ENST00000357649.2_Silent_p.V3505V|PLEC_ENST00000398774.2_Silent_p.V3469V|PLEC_ENST00000354589.3_Silent_p.V3501V|PLEC_ENST00000345136.3_Silent_p.V3501V|PLEC_ENST00000354958.2_Silent_p.V3479V|PLEC_ENST00000527096.1_Silent_p.V3524V|PLEC_ENST00000356346.3_Silent_p.V3487V	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3638	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GGTCCGCCAGGACGCGGTTCA	0.657000													34	186					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16208861	16208861	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:16208861C>T	ENST00000399408.2	+	24	3523	c.3348C>T	c.(3346-3348)atC>atT	p.I1116I	ABCC1_ENST00000399410.3_Silent_p.I1106I|ABCC1_ENST00000346370.5_Silent_p.I1050I|ABCC1_ENST00000345148.5_Silent_p.I1106I|ABCC1_ENST00000351154.5_Silent_p.I1047I|ABCC1_ENST00000349029.5_Silent_p.I991I			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1106	ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTGCCTGCATCGTTATCCTGC	0.567000													11	35					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148406460	148406460	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:148406460C>A	ENST00000538184.1	-	7	2364	c.1476G>T	c.(1474-1476)atG>atT	p.M492I	SH3TC2_ENST00000515425.1_Missense_Mutation_p.M945I|SH3TC2_ENST00000512049.1_Missense_Mutation_p.M938I|SH3TC2_ENST00000394358.2_Missense_Mutation_p.M830I			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	945							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAATGCCATTTCATAAC	0.443000													17	204					1.67942e-08	1.76116e-08	1	1	0
DNAH2	146754	broad.mit.edu	37	17	7701546	7701546	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:7701546C>T	ENST00000572933.1	+	54	9762	c.8302C>T	c.(8302-8304)Cgc>Tgc	p.R2768C	DNAH2_ENST00000389173.2_Missense_Mutation_p.R2768C			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2768	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GGGCAGCGGACGCCAGAGTCT	0.607000													48	33					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195515500	195515500	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:195515500G>A	ENST00000463781.3	-	2	3410	c.2951C>T	c.(2950-2952)tCg>tTg	p.S984L	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.S984L	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	989	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTGGATGCCGAGGAAGCGTA	0.577000													4	43					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51238126	51238126	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:51238126T>A	ENST00000245441.5	-	10	1232	c.1042A>T	c.(1042-1044)Aat>Tat	p.N348Y	NIN_ENST00000530997.2_Missense_Mutation_p.N348Y|NIN_ENST00000389868.3_Missense_Mutation_p.N348Y|NIN_ENST00000382041.3_Missense_Mutation_p.N348Y|NIN_ENST00000382043.4_Missense_Mutation_p.N348Y|NIN_ENST00000453196.1_Missense_Mutation_p.N348Y|NIN_ENST00000324330.9_Missense_Mutation_p.N348Y	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	348	EF-hand 5.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					AAAAGTTCATTTTCAAGGGCC	0.443000			T	PDGFRB	MPD								27	48					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184202007	184202007	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr4:184202007G>C	ENST00000403733.3	+	17	2840	c.2641G>C	c.(2641-2643)Gaa>Caa	p.E881Q	WWC2_ENST00000504005.1_Missense_Mutation_p.E563Q|WWC2_ENST00000513834.1_Missense_Mutation_p.E832Q|WWC2_ENST00000448232.2_Missense_Mutation_p.E881Q	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	881										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		agaagaagaagaagaatcagg	0.443000													3	2					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21457366	21457366	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:21457366T>C	ENST00000307378.6	-	7	1304	c.584A>G	c.(583-585)tAt>tGt	p.Y195C	SLCO1A2_ENST00000458504.1_Missense_Mutation_p.Y63C|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.Y195C|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.Y193C|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.Y63C	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	195					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						CTTACCAATATATAAAGGAGA	0.343000													26	28					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148854978	148854978	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:148854978C>T	ENST00000367467.3	+	15	2281	c.1806C>T	c.(1804-1806)gtC>gtT	p.V602V		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	602	SH3.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ACAACAAAGTCGGCACGTTCA	0.552000													32	77					0	0	1	0	0
NDRG2	57447	broad.mit.edu	37	14	21487277	21487277	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:21487277G>A	ENST00000556147.1	-	11	1699	c.759C>T	c.(757-759)ctC>ctT	p.L253L	NDRG2_ENST00000298684.5_Silent_p.L210L|NDRG2_ENST00000397853.3_Silent_p.L253L|NDRG2_ENST00000397858.1_Silent_p.L253L|NDRG2_ENST00000554277.1_5'UTR|NDRG2_ENST00000397844.2_Silent_p.L239L|NDRG2_ENST00000397851.2_Silent_p.L253L|NDRG2_ENST00000397847.2_Silent_p.L253L|NDRG2_ENST00000360463.3_Silent_p.L239L|NDRG2_ENST00000554104.1_Silent_p.L166L|NDRG2_ENST00000298687.5_Silent_p.L253L|NDRG2_ENST00000350792.3_Silent_p.L239L|NDRG2_ENST00000397855.3_Silent_p.L210L|NDRG2_ENST00000553503.1_Silent_p.L239L|NDRG2_ENST00000554143.1_Silent_p.L239L|NDRG2_ENST00000403829.3_Silent_p.L249L|NDRG2_ENST00000555158.1_Silent_p.L239L|NDRG2_ENST00000397856.3_Silent_p.L239L			Q9UN36	NDRG2_HUMAN	NDRG family member 2	253					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	23	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		AGTCTTACCTGAGGGTGATAT	0.463000													19	46					0	0	1	0	0
SNIP1	79753	broad.mit.edu	37	1	38003454	38003454	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:38003454G>A	ENST00000296215.6	-	4	1158	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F		NM_024700.3	NP_078976.2	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein 1	362					production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			breast(2)|cervix(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(586;0.0393)				CTCTGCTACTGAATCCAAATT	0.428000													38	101					0	0	1	0	0
LAG3	3902	broad.mit.edu	37	12	6884441	6884441	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:6884441C>A	ENST00000203629.2	+	5	1117	c.784C>A	c.(784-786)Ctg>Atg	p.L262M	LAG3_ENST00000441671.2_Missense_Mutation_p.L262M	NM_002286.5	NP_002277.4	P18627	LAG3_HUMAN	lymphocyte-activation gene 3	262						integral to membrane	antigen binding|MHC class II protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						CTCTTCAGGTCTGGAGCCCCC	0.602000													41	160					7.63091e-17	8.33422e-17	1	1	0
PTCH1	5727	broad.mit.edu	37	9	98220567	98220567	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr9:98220567C>T	ENST00000430669.2	-	18	3283	c.2698G>A	c.(2698-2700)Gca>Aca	p.A900T	PTCH1_ENST00000418258.1_Missense_Mutation_p.A815T|PTCH1_ENST00000421141.1_Missense_Mutation_p.A815T|PTCH1_ENST00000429896.2_Missense_Mutation_p.A815T|PTCH1_ENST00000375274.2_Missense_Mutation_p.A965T|PTCH1_ENST00000437951.1_Missense_Mutation_p.A900T|PTCH1_ENST00000331920.6_Missense_Mutation_p.A966T			Q13635	PTC1_HUMAN	patched 1	966					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.I963fs*2(1)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				ATGGGCTCTGCTGCCGGGACT	0.512000													12	15					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85774568	85774568	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:85774568C>T	ENST00000521268.1	+	6	1556	c.451C>T	c.(451-453)Cgt>Tgt	p.R151C	RALYL_ENST00000517638.1_Missense_Mutation_p.R164C|RALYL_ENST00000522455.1_Missense_Mutation_p.R151C|RALYL_ENST00000521376.1_Missense_Mutation_p.R62C|RALYL_ENST00000518566.1_Missense_Mutation_p.R140C|RALYL_ENST00000521695.1_Missense_Mutation_p.R151C|RALYL_ENST00000523850.1_Missense_Mutation_p.R78C	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	151							identical protein binding|nucleotide binding|RNA binding	p.R151G(4)		endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						TCCACCTCCCCGTGCAGTAAT	0.502000													29	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8987333	8987333	+	Splice_Site	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:8987333G>A	ENST00000397910.4	-	68	41957	c.41752_splice	c.e68-1	p.T13918_splice	MUC16_ENST00000380951.5_Splice_Site_p.T559_splice	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13921				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.T13918T(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGACCACCCCGGCTAGGGCAG	0.597000													9	23					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91512372	91512372	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:91512372A>G	ENST00000416354.1	+	25	4433	c.4361A>G	c.(4360-4362)aAt>aGt	p.N1454S	KIF20B_ENST00000394289.2_Missense_Mutation_p.N1424S|KIF20B_ENST00000371728.3_Missense_Mutation_p.N1424S|KIF20B_ENST00000260753.4_Missense_Mutation_p.N1384S|KIF20B_ENST00000478929.1_3'UTR			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1424					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						ACCAAAAACAATCAAAGGTCA	0.299000													12	37					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54387494	54387494	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:54387494G>A	ENST00000542049.1	+	2	112	c.55G>A	c.(55-57)Gga>Aga	p.G19R	PRKCG_ENST00000540413.1_Silent_p.T94T|PRKCG_ENST00000536044.1_Silent_p.T94T|PRKCG_ENST00000263431.3_Silent_p.T94T			P05129	KPCG_HUMAN	protein kinase C, gamma	0					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GCCCCCAGACGGACGTGAGTG	0.582000													24	67					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	128795100	128795100	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:128795100C>T	ENST00000280333.6	+	7	671	c.562C>T	c.(562-564)Cat>Tat	p.H188Y		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	188					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.H188Y(1)		NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CTTCAGAGCTCATGAAATAGC	0.363000													60	57					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157805814	157805814	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:157805814G>A	ENST00000368174.4	-	3	283	c.187C>T	c.(187-189)Cgg>Tgg	p.R63W	CD5L_ENST00000484609.1_5'UTR	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	63	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCCAGCTCCCGGCACAACACA	0.577000													87	67					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32712325	32712325	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:32712325C>T	ENST00000265074.8	+	1	786	c.443C>T	c.(442-444)tCg>tTg	p.S148L	NPR3_ENST00000415167.2_Missense_Mutation_p.S148L|NPR3_ENST00000434067.2_Intron|NPR3_ENST00000415685.2_Intron	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	148					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	CGGCTTGCATCGCACTGGGAC	0.701000													30	84					0	0	1	0	0
SRRM5	100170229	broad.mit.edu	37	19	44118399	44118399	+	Nonsense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:44118399C>A	ENST00000526798.1	+	3	2448	c.2171C>A	c.(2170-2172)tCa>tAa	p.S724*	ZNF428_ENST00000300811.3_Missense_Mutation_p.D20Y|SRRM5_ENST00000607544.1_Nonsense_Mutation_p.S709*|SRRM5_ENST00000417606.1_Nonsense_Mutation_p.S709*			B3KS81	SRRM5_HUMAN	serine/arginine repetitive matrix 5	709										endometrium(11)|kidney(2)|skin(1)|stomach(1)	15						AGGTCTTCATCATCTTCTTCC	0.592000													18	33					2.37509e-13	2.5703e-13	1	1	0
TPD52	7163	broad.mit.edu	37	8	80992685	80992685	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:80992685C>T	ENST00000520527.1	-	1	366	c.4G>A	c.(4-6)Gat>Aat	p.D2N	TPD52_ENST00000519303.2_Intron|TPD52_ENST00000518937.1_Intron|TPD52_ENST00000517427.1_Missense_Mutation_p.D2N|TPD52_ENST00000537855.1_Missense_Mutation_p.D2N|TPD52_ENST00000379097.3_Missense_Mutation_p.D2N|TPD52_ENST00000448733.2_Missense_Mutation_p.D2N|TPD52_ENST00000379096.5_Intron			P55327	TPD52_HUMAN	tumor protein D52	2					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	8	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TCTCTACAATCCATTCCAGAC	0.453000													14	62					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16279195	16279195	+	Splice_Site	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr22:16279195C>A	ENST00000343518.6	-	4	1079	c.1028_splice	c.e4+1	p.R343_splice		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	343										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						AGAACTATACCTTCCATATCT	0.303000													22	112					1.10923e-09	1.17887e-09	1	1	0
ANK3	288	broad.mit.edu	37	10	61829895	61829895	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:61829895T>C	ENST00000280772.1	-	37	10935	c.10744A>G	c.(10744-10746)Aca>Gca	p.T3582A	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3582					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCTGGCGTTGTATCAGGGGTT	0.493000													55	52					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	354309	354309	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:354309G>A	ENST00000262320.3	-	5	1620	c.1249C>T	c.(1249-1251)Cgc>Tgc	p.R417C	AXIN1_ENST00000481769.1_5'UTR|AXIN1_ENST00000354866.3_Missense_Mutation_p.R417C	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	417	Interaction with GSK3B (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.?(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CTCACCATGCGCACGCGCTTC	0.677000													31	33					0	0	1	0	0
SIRT1	23411	broad.mit.edu	37	10	69672542	69672542	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:69672542G>A	ENST00000212015.6	+	8	1722	c.1669G>A	c.(1669-1671)Gac>Aac	p.D557N	SIRT1_ENST00000432464.1_Missense_Mutation_p.D262N|SIRT1_ENST00000403579.1_Missense_Mutation_p.D254N|SIRT1_ENST00000406900.1_Missense_Mutation_p.D254N	NM_012238.4	NP_036370.2	Q96EB6	SIRT1_HUMAN	sirtuin 1	557					apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	14						CACACTTTTAGACCAAGCAGC	0.393000													74	45					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57690482	57690482	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:57690482C>T	ENST00000562631.1	+	9	1652	c.1120C>T	c.(1120-1122)Caa>Taa	p.Q374*	GPR56_ENST00000538815.1_Nonsense_Mutation_p.Q374*|GPR56_ENST00000456916.1_Nonsense_Mutation_p.Q374*|GPR56_ENST00000388813.5_Nonsense_Mutation_p.Q374*|GPR56_ENST00000544297.1_Nonsense_Mutation_p.Q199*|GPR56_ENST00000568908.1_Nonsense_Mutation_p.Q374*|GPR56_ENST00000568909.1_Nonsense_Mutation_p.Q374*|GPR56_ENST00000379696.3_Nonsense_Mutation_p.Q374*|GPR56_ENST00000567835.1_Nonsense_Mutation_p.Q374*|GPR56_ENST00000388812.4_Nonsense_Mutation_p.Q374*|GPR56_ENST00000540164.2_Nonsense_Mutation_p.Q374*|GPR56_ENST00000379694.4_Nonsense_Mutation_p.Q204*|GPR56_ENST00000562558.1_Nonsense_Mutation_p.Q374*			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	374	GPS.				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						GAGAGAAACCCAAACATCCTG	0.607000													40	76					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132511992	132511992	+	Silent	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:132511992G>C	ENST00000333577.4	+	27	5242	c.5133G>C	c.(5131-5133)ccG>ccC	p.P1711P	EP400_ENST00000389561.2_Silent_p.P1675P|EP400_ENST00000332482.4_Silent_p.P1638P|EP400_ENST00000330386.6_Silent_p.P1594P|EP400_ENST00000389562.2_Silent_p.P1674P			Q96L91	EP400_HUMAN	E1A binding protein p400	1711					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTGGCGTTCCGGGCCGCGTGG	0.562000													19	34					0	0	1	0	0
PKN1	5585	broad.mit.edu	37	19	14581060	14581060	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:14581060G>A	ENST00000242783.6	+	19	2544	c.2379G>A	c.(2377-2379)acG>acA	p.T793T	PKN1_ENST00000342216.4_Silent_p.T799T	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	793	Protein kinase.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						CGTCGTACACGCGAGCTGTGG	0.637000													14	29					0	0	1	0	0
WBP1L	54838	broad.mit.edu	37	10	104572904	104572904	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:104572904A>G	ENST00000369889.4	+	4	987	c.845A>G	c.(844-846)gAc>gGc	p.D282G	WBP1L_ENST00000448841.1_Missense_Mutation_p.D303G	NM_017787.4	NP_060257.4	Q9NX94	OPA1L_HUMAN	WW domain binding protein 1-like	282						integral to membrane											GGGCCCCTGGACTTCTGCGAC	0.607000													62	63					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18845998	18845998	+	RNA	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr22:18845998G>A	ENST00000412938.1	+	0	3356																											CCCGTCCTGCGCAGGCCGACA	0.607000													4	79					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105763081	105763081	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:105763081C>T	ENST00000369755.3	+	9	2690	c.2145C>T	c.(2143-2145)atC>atT	p.I715I	SLK_ENST00000335753.4_Silent_p.I715I	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	715					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GTATTAATATCAACTCTGACA	0.348000													47	47					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18845990	18845990	+	RNA	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr22:18845990C>T	ENST00000412938.1	+	0	3348																											ACCTCCATCCCGTCCTGCGCA	0.582000													5	75					0	0	1	0	0
ARID3B	10620	broad.mit.edu	37	15	74887992	74887992	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:74887992G>A	ENST00000346246.5	+	9	1791	c.1560G>A	c.(1558-1560)acG>acA	p.T520T		NM_006465.2	NP_006456.1	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B (BRIGHT-like)	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(2)	14						ACCTCATCACGGGGTCTGCTC	0.642000													5	33					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653694	159653694	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:159653694C>T	ENST00000297267.9	+	11	2350	c.2150C>T	c.(2149-2151)tCa>tTa	p.S717L	FNDC1_ENST00000340366.6_Missense_Mutation_p.S654L	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	717	Ser-rich.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCCCACCCTCAAGACTTTCT	0.657000													3	17					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120817671	120817671	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:120817671C>T	ENST00000369144.3	-	12	1901	c.1774G>A	c.(1774-1776)Gaa>Aaa	p.E592K	EIF3A_ENST00000541549.1_Missense_Mutation_p.E558K|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	592	Glu-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TCCAATTCTTCTTTCTCACGC	0.502000													20	25					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59350698	59350698	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:59350698G>A	ENST00000348370.4	+	5	1748	c.1315G>A	c.(1315-1317)Gag>Aag	p.E439K	RNF111_ENST00000434298.1_Missense_Mutation_p.E439K|RNF111_ENST00000557998.1_Missense_Mutation_p.E439K|RNF111_ENST00000561186.1_Missense_Mutation_p.E439K|RNF111_ENST00000559209.1_Missense_Mutation_p.E439K	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	439	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		CACAGTGTCAGAGACTTCAGC	0.448000													144	218					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42471431	42471431	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:42471431G>A	ENST00000545399.1	-	22	3175	c.3022C>T	c.(3022-3024)Cgc>Tgc	p.R1008C	ATP1A3_ENST00000302102.5_Missense_Mutation_p.R995C|ATP1A3_ENST00000602133.1_Missense_Mutation_p.R965C|ATP1A3_ENST00000543770.1_Missense_Mutation_p.R1006C	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	995					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.R995C(1)		NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						ATGAGTTTGCGGATTTCGTCG	0.662000													8	35					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25404708	25404708	+	Missense_Mutation	SNP	A	A	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr13:25404708A>C	ENST00000255324.5	+	17	2384	c.2332A>C	c.(2332-2334)Aag>Cag	p.K778Q	RNF17_ENST00000381921.1_Missense_Mutation_p.K778Q	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	778	Tudor 1.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GCGTAAAATAAAGGATGAGTT	0.328000													24	42					0	0	1	0	0
CRYGD	1421	broad.mit.edu	37	2	208986513	208986513	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:208986513A>G	ENST00000264376.4	-	3	436	c.409T>C	c.(409-411)Tcc>Ccc	p.S137P		NM_006891.3	NP_008822.2	P07320	CRGD_HUMAN	crystallin, gamma D	137	Beta/gamma crystallin 'Greek key' 4.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens			breast(1)|endometrium(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		CGGTAGTTGGACAGCTCGTAG	0.592000													35	63					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25430620	25430620	+	RNA	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:25430620G>A	ENST00000424208.1	+	0	481					NR_003305.1																						ATTGCGTTAGGCCCTTTGGCC	0.587000													10	11					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16208862	16208862	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:16208862G>T	ENST00000399408.2	+	24	3524	c.3349G>T	c.(3349-3351)Gtt>Ttt	p.V1117F	ABCC1_ENST00000399410.3_Missense_Mutation_p.V1107F|ABCC1_ENST00000346370.5_Missense_Mutation_p.V1051F|ABCC1_ENST00000345148.5_Missense_Mutation_p.V1107F|ABCC1_ENST00000351154.5_Missense_Mutation_p.V1048F|ABCC1_ENST00000349029.5_Missense_Mutation_p.V992F			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1107	ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGCCTGCATCGTTATCCTGCT	0.572000													12	34					0.000151284	0.000154545	1	1	0
SLC6A5	9152	broad.mit.edu	37	11	20636288	20636288	+	Missense_Mutation	SNP	C	C	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:20636288C>A	ENST00000525748.1	+	6	1322	c.1049C>A	c.(1048-1050)gCt>gAt	p.A350D		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	350					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	TGCATGACCGCTTATCCCAAC	0.398000													73	32					8.73484e-25	9.71905e-25	1	1	0
LOC101927079	101927079	broad.mit.edu	37	15	22332570	22332570	+	RNA	SNP	T	T	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:22332570T>C	ENST00000558896.1	+	0	377																											CCCATGCTCATCTGCTCCAAT	0.398000													6	127					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100339997	100339997	+	RNA	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:100339997G>C	ENST00000341853.1	-	0	929					NR_003260.1																						GTGTCTTCTCGTTCCCACGCG	0.612000													4	40					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1094756	1094756	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:1094756G>A	ENST00000441003.2	+	31	5871	c.5844G>A	c.(5842-5844)acG>acA	p.T1948T	MUC2_ENST00000361558.6_Silent_p.T86T|MUC2_ENST00000333592.6_Silent_p.T236T	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1979						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGACCCCAACGCCGACCCCAC	0.632000													74	28					0	0	1	0	0
UTP14A	10813	broad.mit.edu	37	X	129063563	129063563	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrX:129063563G>A	ENST00000394422.3	+	15	2323	c.2295G>A	c.(2293-2295)ctG>ctA	p.L765L	UTP14A_ENST00000371051.5_Silent_p.L711L|RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000425117.2_Silent_p.L713L|UTP14A_ENST00000371042.3_Silent_p.L597L	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	765					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						AAAAACAGCTGAAGAAATGCT	0.483000													32	10					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134153352	134153352	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:134153352A>G	ENST00000452510.2	+	20	2938	c.2780A>G	c.(2779-2781)aAt>aGt	p.N927S	DDX46_ENST00000354283.4_Missense_Mutation_p.N926S	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	926					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTGGACAGAATGAATCTTTT	0.373000													9	38					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8745848	8745848	+	Nonsense_Mutation	SNP	A	A	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr20:8745848A>T	ENST00000378641.3	+	26	3248	c.2773A>T	c.(2773-2775)Aaa>Taa	p.K925*	PLCB1_ENST00000338037.6_Nonsense_Mutation_p.K925*|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Nonsense_Mutation_p.K925*	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	925					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ACTTCAAAAGAAACACTACAA	0.373000													13	52					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128099532	128099532	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr9:128099532T>A	ENST00000470056.1	+	15	2699	c.2539T>A	c.(2539-2541)Tat>Aat	p.Y847N	GAPVD1_ENST00000394105.2_Missense_Mutation_p.Y874N|GAPVD1_ENST00000297933.6_Missense_Mutation_p.Y847N|GAPVD1_ENST00000265956.4_Missense_Mutation_p.Y821N|GAPVD1_ENST00000394083.2_Missense_Mutation_p.Y826N|GAPVD1_ENST00000394104.2_Missense_Mutation_p.Y847N|GAPVD1_ENST00000312123.9_Missense_Mutation_p.Y826N|GAPVD1_ENST00000495955.1_Missense_Mutation_p.Y847N			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	847					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						AAAGGTTCACTATGCTAGGCC	0.478000													63	51					0	0	1	0	0
DNAJB9	4189	broad.mit.edu	37	7	108213675	108213675	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:108213675T>A	ENST00000249356.3	+	3	1096	c.550T>A	c.(550-552)Tct>Act	p.S184T	DNAJB9_ENST00000465725.1_Intron	NM_012328.2	NP_036460.1	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	184					ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13						TGGTTTTGACTCTACCAATCA	0.358000													42	49					0	0	1	0	0
PPP1R18	170954	broad.mit.edu	37	6	30653531	30653531	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:30653531G>A	ENST00000274853.3	-	1	2141	c.265C>T	c.(265-267)Cga>Tga	p.R89*	PPP1R18_ENST00000488324.1_Intron|PPP1R18_ENST00000399199.3_Nonsense_Mutation_p.R89*	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	89						cytoplasm|cytoskeleton	actin binding										CGGATGAATCGGTTCTGGTGC	0.637000													14	16					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158604380	158604380	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:158604380C>T	ENST00000368148.3	-	39	5698	c.5518G>A	c.(5518-5520)Gct>Act	p.A1840T	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.A1840T	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1840					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ACAGCCAAAGCATTCTTTTCA	0.403000													45	49					0	0	1	0	0
PPM1B	5495	broad.mit.edu	37	2	44428690	44428690	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:44428690C>T	ENST00000378551.2	+	2	764	c.352C>T	c.(352-354)Cgt>Tgt	p.R118C	PPM1B_ENST00000378540.4_3'UTR|PPM1B_ENST00000345249.4_Intron|PPM1B_ENST00000409895.4_Missense_Mutation_p.R118C|PPM1B_ENST00000409432.3_Missense_Mutation_p.R118C|PPM1B_ENST00000282412.4_Missense_Mutation_p.R118C	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	118					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGAATACATGCGTAACTTTTC	0.403000													20	79					0	0	1	0	0
MC1R	4157	broad.mit.edu	37	16	89986228	89986228	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:89986228G>A	ENST00000555427.1	+	3	2865	c.562G>A	c.(562-564)Gtc>Atc	p.V188I	MC1R_ENST00000555147.1_Missense_Mutation_p.V188I|TUBB3_ENST00000556922.1_Missense_Mutation_p.V188I					melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CCACGTGGCCGTCCTGCTGTG	0.667000									Melanoma, Familial Clustering of				12	43					0	0	1	0	0
THAP3	90326	broad.mit.edu	37	1	6688643	6688643	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:6688643C>T	ENST00000377627.3	+	2	186	c.159C>T	c.(157-159)gtC>gtT	p.V53V	THAP3_ENST00000054650.4_Silent_p.V53V|THAP3_ENST00000307896.6_Silent_p.V53V	NM_138350.3	NP_612359.2	Q8WTV1	THAP3_HUMAN	THAP domain containing, apoptosis associated protein 3	53							DNA binding|metal ion binding			breast(1)|cervix(1)|large_intestine(1)|prostate(1)	4	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		AGCACACGGTCATCTGCTCCG	0.602000													21	58					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96705555	96705555	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr13:96705555C>T	ENST00000376747.3	-	1	82	c.12G>A	c.(10-12)gcG>gcA	p.A4A	UGGT2_ENST00000397618.3_Silent_p.A4A|UGGT2_ENST00000376714.3_Silent_p.A4A|UGGT2_ENST00000376712.4_Silent_p.A4A	NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	4					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						TCGTGGCTTTCGCTGGCGCCA	0.692000													5	14					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21992396	21992396	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:21992396A>G	ENST00000594012.1	-	7	939	c.425T>C	c.(424-426)tTt>tCt	p.F142S	ZNF43_ENST00000354959.4_Missense_Mutation_p.F148S|ZNF43_ENST00000598381.1_Missense_Mutation_p.F142S|ZNF43_ENST00000595461.1_Missense_Mutation_p.F142S	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		ACATTTATCAAATAGAAATAT	0.323000													21	30					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75230901	75230901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:75230901C>T	ENST00000325680.7	+	1	833	c.709C>T	c.(709-711)Cag>Tag	p.Q237*	YLPM1_ENST00000552421.1_Nonsense_Mutation_p.Q237*|YLPM1_ENST00000238571.3_Nonsense_Mutation_p.Q237*	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCGCCCCTCCCAGGGCCATTC	0.562000													24	74					0	0	1	0	0
LRP5L	91355	broad.mit.edu	37	22	25771949	25771949	+	Translation_Start_Site	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr22:25771949G>A	ENST00000444995.3	-	0	400				LRP5L_ENST00000402859.2_De_novo_Start_OutOfFrame			A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein 5-like											central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(2)	6						GAAGGGGTGCGTCAGGCTGCC	0.607000													11	9					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52498061	52498061	+	Missense_Mutation	SNP	A	A	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:52498061A>C	ENST00000261839.7	-	37	4650	c.4489T>G	c.(4489-4491)Tat>Gat	p.Y1497D	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1497	Dilute.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AATTGATGATATATTCGTATA	0.299000													24	61					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871909	51871909	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr20:51871909G>A	ENST00000371497.5	+	2	2799	c.1912G>A	c.(1912-1914)Gaa>Aaa	p.E638K	TSHZ2_ENST00000603338.2_Missense_Mutation_p.E635K|TSHZ2_ENST00000329613.6_Missense_Mutation_p.E635K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	638					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CCGCAAAAGTGAAACACCTCC	0.537000													24	71					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212812	26212812	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrX:26212812G>A	ENST00000379034.1	+	2	998	c.849G>A	c.(847-849)ccG>ccA	p.P283P		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	283	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						ATGCGCTGCCGAAGTCGGGTC	0.527000													57	20					0	0	1	0	0
PRKAR1A	5573	broad.mit.edu	37	17	66526546	66526546	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:66526546C>T	ENST00000589228.1	+	11	1230	c.1102C>T	c.(1102-1104)Cga>Tga	p.R368*	PRKAR1A_ENST00000392711.1_Nonsense_Mutation_p.R368*|PRKAR1A_ENST00000588188.2_Intron|PRKAR1A_ENST00000586397.1_Nonsense_Mutation_p.R368*|PRKAR1A_ENST00000358598.2_Nonsense_Mutation_p.R368*|PRKAR1A_ENST00000536854.2_Nonsense_Mutation_p.R368*	NM_001276289.1|NM_001278433.1	NP_001263218.1|NP_001265362.1	P10644	KAP0_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, alpha	368					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|soft_tissue(2)|stomach(2)|testis(1)|thyroid(2)|upper_aerodigestive_tract(1)	31	Breast(10;1.64e-13)					CATCCTCAAACGAAACATCCA	0.512000			"""T, Mis, N, F, S"""	RET	papillary thyroid	"""myxoma, endocrine, papillary thyroid"""			Primary Pigmented Nodular Adrenocortical Disease, Familial;Carney Complex;Cardiac Myxomas, Familial Clustering of				21	82					0	0	1	0	0
CCSER2	54462	broad.mit.edu	37	10	86132166	86132166	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:86132166C>T	ENST00000224756.8	+	2	1543	c.1358C>T	c.(1357-1359)cCc>cTc	p.P453L	CCSER2_ENST00000372088.2_Missense_Mutation_p.P453L|CCSER2_ENST00000359979.4_Missense_Mutation_p.P453L	NM_018999.2	NP_061872.2			coiled-coil serine-rich protein 2																		TTTGATTCCCCCAAGGAAAAT	0.343000													26	83					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13288	13288	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrM:13288G>A	ENST00000361567.2	+	1	952	c.952G>A	c.(952-954)Ggc>Agc	p.G318S				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	318					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TAGTTACAATCGGCATCAACC	0.458000													5	11					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96429180	96429180	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:96429180C>T	ENST00000228740.2	-	1	259	c.118G>A	c.(118-120)Gct>Act	p.A40T	LTA4H_ENST00000413268.2_Intron|LTA4H_ENST00000552789.1_Intron	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	40					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						ACCGTGAGAGCAGCAGTCCCG	0.672000													9	9					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	14026302	14026302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:14026302G>A	ENST00000343495.5	-	5	880	c.142C>T	c.(142-144)Caa>Taa	p.Q48*	ETV1_ENST00000405218.2_Nonsense_Mutation_p.Q48*|ETV1_ENST00000405358.4_Nonsense_Mutation_p.Q62*|ETV1_ENST00000405192.2_Nonsense_Mutation_p.Q48*|ETV1_ENST00000403685.1_Nonsense_Mutation_p.Q48*|ETV1_ENST00000430479.1_Nonsense_Mutation_p.Q48*|ETV1_ENST00000242066.5_Nonsense_Mutation_p.Q48*			P50549	ETV1_HUMAN	ets variant 1	48					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						CTTAGATCTTGAAAGAGTTCT	0.303000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								7	39					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15288454	15288454	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:15288454C>G	ENST00000263388.2	-	24	4360	c.4285G>C	c.(4285-4287)Gag>Cag	p.E1429Q		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1429					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGCAGCGCCTCGCATTGCCGC	0.726000													3	7					0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97217910	97217910	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:97217910G>A	ENST00000454558.2	+	7	2618	c.1441G>A	c.(1441-1443)Gct>Act	p.A481T	ARID5A_ENST00000357485.3_Missense_Mutation_p.A549T			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	549					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						GCCCATGGCCGCTGGCCTGAT	0.687000													48	136					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224633	26224633	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:26224633C>G	ENST00000056233.3	+	4	1574	c.1315C>G	c.(1315-1317)Cac>Gac	p.H439D		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	439					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						TAATTCCTCTCACTCTGTGTG	0.413000													68	104					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5933374	5933374	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:5933374C>T	ENST00000378156.4	-	23	3518	c.3253G>A	c.(3253-3255)Gag>Aag	p.E1085K	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	1085					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		ATGCCCTTCTCGTTGCTCAAC	0.577000													26	61					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32712623	32712623	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:32712623C>T	ENST00000265074.8	+	1	1084	c.741C>T	c.(739-741)atC>atT	p.I247I	NPR3_ENST00000415167.2_Silent_p.I247I|NPR3_ENST00000434067.2_Intron|NPR3_ENST00000415685.2_Intron	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	247					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	TGGAAGACATCGTGCGCAATA	0.622000													60	70					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49639162	49639162	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:49639162C>T	ENST00000334186.4	+	14	1996	c.1647C>T	c.(1645-1647)gtC>gtT	p.V549V	PPFIA3_ENST00000602351.1_Silent_p.V549V	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	549						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GGTCAGGGGTCAAGGAGGAGC	0.627000													8	19					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987898	61987898	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr13:61987898C>T	ENST00000409186.1	-	5	2439	c.334G>A	c.(334-336)Gag>Aag	p.E112K	PCDH20_ENST00000409204.4_Missense_Mutation_p.E112K			Q8N6Y1	PCD20_HUMAN	protocadherin 20	85	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGGTTCCACTCAGCACCGGTG	0.687000													4	24					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248201645	248201645	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:248201645G>A	ENST00000366479.2	+	1	172	c.76G>A	c.(76-78)Gta>Ata	p.V26I	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V26L(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGGCCTTTTCGTATTCACCCT	0.378000													21	122					0	0	1	0	0
METTL8	79828	broad.mit.edu	37	2	172187192	172187192	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:172187192C>T	ENST00000375258.3	-	7	952	c.737G>A	c.(736-738)aGa>aAa	p.R246K				B3KW44	B3KW44_HUMAN	methyltransferase like 8	246							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						CTGGGTTGCTCTGTAGGACGA	0.388000													25	21					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69874115	69874115	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:69874115G>C	ENST00000359154.2	+	5	528	c.427G>C	c.(427-429)Ggg>Cgg	p.G143R	WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000542271.1_Missense_Mutation_p.G27R|WWP2_ENST00000356003.2_Missense_Mutation_p.G143R|WWP2_ENST00000448661.1_Missense_Mutation_p.G143R|WWP2_ENST00000569174.1_Missense_Mutation_p.G143R	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	143					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity	p.G143R(1)		breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTTCCTGGACGGGCCAACTGT	0.582000													24	82					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71068871	71068871	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:71068871T>A	ENST00000452400.2	-	11	1910	c.1729A>T	c.(1729-1731)Atg>Ttg	p.M577L	NCOA2_ENST00000524223.1_5'UTR	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	577					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AAGCTTCCCATCTTGCTGAGT	0.493000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								32	147					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79693186	79693186	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:79693186G>A	ENST00000261205.4	+	8	1322	c.665G>A	c.(664-666)gGc>gAc	p.G222D	SYT1_ENST00000393240.3_Missense_Mutation_p.G222D|SYT1_ENST00000552744.1_Missense_Mutation_p.G222D|SYT1_ENST00000457153.2_Missense_Mutation_p.G219D	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	222	C2 1.|Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						GAATTGGGTGGCAAAACCCTA	0.358000													4	148					0	0	1	0	0
C2orf82	389084	broad.mit.edu	37	2	233740979	233740979	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:233740979C>G	ENST00000409230.1	+	4	526	c.279C>G	c.(277-279)atC>atG	p.I93M	C2orf82_ENST00000409533.1_Missense_Mutation_p.I93M|C2orf82_ENST00000331342.2_Missense_Mutation_p.I93M			Q6UX34	CB082_HUMAN	chromosome 2 open reading frame 82	93						integral to membrane											CCGGCGCTATCGCGGCCATCG	0.716000													5	2					0	0	1	0	0
DGCR5	26220	broad.mit.edu	37	22	18979485	18979485	+	RNA	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr22:18979485A>G	ENST00000438934.1	+	0	2836				DGCR5_ENST00000440005.2_RNA																							GTGTTCTGGAACCATTCCCTG	0.587000													9	16					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946396	16946396	+	RNA	SNP	C	C	T	rs367013	byFrequency	TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:16946396C>T	ENST00000412962.1	-	0	1123																											TGCTGCAGGGCAGCAATCTCC	0.667000													11	30					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135251515	135251515	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr9:135251515C>T	ENST00000334270.2	-	11	2544	c.2505G>A	c.(2503-2505)ctG>ctA	p.L835L	TTF1_ENST00000461970.1_5'UTR	NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	835					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ACTTTTCCTTCAGCAAAGGTA	0.383000													40	73					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61495637	61495637	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:61495637G>A	ENST00000257215.5	+	7	765	c.649G>A	c.(649-651)Gaa>Aaa	p.E217K		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	217					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		TGCCTACTCAGAAATCGCCTA	0.622000													29	52					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	110221803	110221803	+	Silent	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr4:110221803G>T	ENST00000399132.1	-	3	833	c.303C>A	c.(301-303)tcC>tcA	p.S101S	COL25A1_ENST00000399126.1_Silent_p.S101S|COL25A1_ENST00000399127.1_Silent_p.S101S	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	101						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TATGTTCATAGGATTTCTGTA	0.403000													13	18					4.3838e-07	4.53695e-07	1	1	0
IVL	3713	broad.mit.edu	37	1	152883971	152883971	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:152883971G>A	ENST00000368764.3	+	2	1762	c.1698G>A	c.(1696-1698)ttG>ttA	p.L566L	IVL_ENST00000392667.2_Silent_p.L420L			P07476	INVO_HUMAN	involucrin	566					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGAAGTATTGCTTCCTGTAG	0.572000													10	74					0	0	1	0	0
RASA1	5921	broad.mit.edu	37	5	86633825	86633825	+	Nonsense_Mutation	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:86633825G>T	ENST00000456692.2	+	5	518	c.403G>T	c.(403-405)Gaa>Taa	p.E135*	RASA1_ENST00000512763.1_Nonsense_Mutation_p.E145*|RASA1_ENST00000506290.1_Nonsense_Mutation_p.E146*|RASA1_ENST00000274376.6_Nonsense_Mutation_p.E312*	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	312	Poly-Pro.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TGTTCATAATGAATTAGAAGA	0.274000													19	43					7.07596e-05	7.25975e-05	1	1	0
CACNA1H	8912	broad.mit.edu	37	16	1250562	1250562	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:1250562C>T	ENST00000348261.5	+	7	1358	c.1110C>T	c.(1108-1110)gcC>gcT	p.A370A	CACNA1H_ENST00000358590.4_Silent_p.A370A|CACNA1H_ENST00000565831.1_Silent_p.A370A	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	370					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCTGGATTGCCATCTTCCAGG	0.657000													11	49					0	0	1	0	0
SIX1	6495	broad.mit.edu	37	14	61115425	61115425	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:61115425G>A	ENST00000247182.6	-	1	755	c.483C>T	c.(481-483)acC>acT	p.T161T	SIX1_ENST00000554986.1_Intron	NM_005982.3	NP_005973.1	Q15475	SIX1_HUMAN	SIX homeobox 1	161					branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		TGGTGAGGCCGGTGGCCTCGG	0.652000													34	40					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76455961	76455961	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:76455961C>T	ENST00000389840.5	-	60	9640	c.9516G>A	c.(9514-9516)gcG>gcA	p.A3172A	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.A3181A					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGATCTTGGCCGCCTTCCAGC	0.597000													49	35					0	0	1	0	0
NAA35	60560	broad.mit.edu	37	9	88636841	88636841	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr9:88636841C>T	ENST00000361671.5	+	23	2277	c.2144C>T	c.(2143-2145)gCt>gTt	p.A715V		NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	715					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						GATTTCTCTGCTCATAAATAT	0.373000													16	44					0	0	1	0	0
GATA1	2623	broad.mit.edu	37	X	48651673	48651673	+	Missense_Mutation	SNP	A	A	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrX:48651673A>C	ENST00000376670.3	+	5	950	c.839A>C	c.(838-840)aAt>aCt	p.N280T	GATA1_ENST00000376665.3_Missense_Mutation_p.N280T	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	280					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						CCCGTGTGCAATGCCTGCGGC	0.602000			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								27	11					0	0	1	0	0
C17orf102	400591	broad.mit.edu	37	17	32906293	32906293	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:32906293C>G	ENST00000357754.1	-	1	95	c.7G>C	c.(7-9)Gat>Cat	p.D3H		NM_207454.2	NP_997337.2	A2RUQ5	CQ102_HUMAN	chromosome 17 open reading frame 102	3										central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(3)|ovary(1)	9						AAGGAAAAATCAAACATAAAA	0.642000													5	8					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389562.2_Silent_p.Q2724Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													4	77					0	0	1	0	0
DCTN2	10540	broad.mit.edu	37	12	57939816	57939816	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:57939816C>T	ENST00000548249.1	-	2	367	c.100G>A	c.(100-102)Gat>Aat	p.D34N	DCTN2_ENST00000543672.1_Missense_Mutation_p.D34N|DCTN2_ENST00000434715.3_Missense_Mutation_p.D34N	NM_001261412.1|NM_001261413.1	NP_001248341.1|NP_001248342.1	Q13561	DCTN2_HUMAN	dynactin 2 (p50)	34					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|upper_aerodigestive_tract(2)	11						CTTACCGCATCGAACTCCGCT	0.542000													5	106					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12978453	12978453	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:12978453G>A	ENST00000251472.4	+	19	2344	c.2305G>A	c.(2305-2307)Ggc>Agc	p.G769S		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	769					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CTGGAGAGGGGGCTCTCCGGA	0.682000													9	8					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32945187	32945187	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr13:32945187G>C	ENST00000544455.1	+	20	8809	c.8582G>C	c.(8581-8583)aGa>aCa	p.R2861T	BRCA2_ENST00000380152.3_Missense_Mutation_p.R2861T	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2861					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAACAAAAGAGACTAGAAGCC	0.343000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			18	59					0	0	1	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27834714	27834714	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:27834714C>T	ENST00000331442.3	-	1	645	c.594G>A	c.(592-594)ccG>ccA	p.P198P		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	198					nucleosome assembly	nucleosome|nucleus	DNA binding	p.P198P(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						TTGCCGCCTTCGGCTTAACTG	0.557000													25	45					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	109					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57493504	57493504	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:57493504C>T	ENST00000351747.2	-	8	943	c.763G>A	c.(763-765)Gca>Aca	p.A255T	DNAH12_ENST00000389536.4_Missense_Mutation_p.A255T|DNAH12_ENST00000311202.6_Missense_Mutation_p.A255T	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	255	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						TTCTCTTCTGCGTTTCTAGTT	0.333000													26	64					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11926970	11926970	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:11926970C>T	ENST00000339865.5	+	7	1403	c.640C>T	c.(640-642)Caa>Taa	p.Q214*	USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Nonsense_Mutation_p.Q302*|USP47_ENST00000527733.1_Nonsense_Mutation_p.Q282*	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	302					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		TGAGCTATATCAAGGCAAGCT	0.343000													17	18					0	0	1	0	0
POT1	25913	broad.mit.edu	37	7	124469392	124469392	+	Missense_Mutation	SNP	T	T	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:124469392T>C	ENST00000357628.3	-	16	2108	c.1510A>G	c.(1510-1512)Aaa>Gaa	p.K504E	POT1_ENST00000393329.1_Missense_Mutation_p.K373E	NM_015450.2	NP_056265.2	Q9NUX5	POTE1_HUMAN	protection of telomeres 1	504					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						GAACACTGTTTACATCTGAAA	0.284000													21	45					0	0	1	0	0
LYZL1	84569	broad.mit.edu	37	10	29599113	29599113	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:29599113T>A	ENST00000375500.3	+	4	568	c.511T>A	c.(511-513)Tat>Aat	p.Y171N		NM_032517.4	NP_115906.3	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	125					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|cervix(2)|large_intestine(2)|lung(5)|skin(1)	11		Breast(68;0.203)				AGGAATGAACTATTGGTAAGA	0.418000													19	70					0	0	1	0	0
CCDC142	84865	broad.mit.edu	37	2	74708183	74708183	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:74708183G>T	ENST00000393965.3	-	4	1685	c.1289C>A	c.(1288-1290)aCc>aAc	p.T430N	CCDC142_ENST00000290418.4_Missense_Mutation_p.T423N|CCDC142_ENST00000471713.1_5'UTR	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	430										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						GGTCTGAAGGGTACAGAGACC	0.547000													20	58					1.96292e-10	2.10503e-10	1	1	0
THAP2	83591	broad.mit.edu	37	12	72068119	72068119	+	Nonsense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:72068119C>T	ENST00000308086.2	+	2	1709	c.208C>T	c.(208-210)Cga>Tga	p.R70*	RP11-293I14.2_ENST00000548802.1_Nonsense_Mutation_p.R46*	NM_031435.3	NP_113623.1	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated protein 2	70						nucleolus	DNA binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	10						ACAAACTCGACGACTTAAAAT	0.373000													4	159					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	83635667	83635667	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr10:83635667G>T	ENST00000404547.1	+	1	571	c.571G>T	c.(571-573)Gcg>Tcg	p.A191S	NRG3_ENST00000372141.2_Missense_Mutation_p.A191S			P56975	NRG3_HUMAN	neuregulin 3	191	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TGCGGCCCCTGCGACGGTCCC	0.716000													14	62					1.15088e-07	1.20158e-07	1	1	0
CASR	846	broad.mit.edu	37	3	121980461	121980461	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:121980461G>A	ENST00000498619.1	+	4	1017	c.579G>A	c.(577-579)caG>caA	p.Q193Q	CASR_ENST00000296154.5_Silent_p.Q193Q|CASR_ENST00000490131.1_Silent_p.Q193Q	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	193					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	ATGAGCACCAGGCCACTGCCA	0.527000													38	123					0	0	1	0	0
SLC11A2	4891	broad.mit.edu	37	12	51382111	51382111	+	Silent	SNP	T	T	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:51382111T>C	ENST00000394904.3	-	16	1819	c.1770A>G	c.(1768-1770)aaA>aaG	p.K590K	SLC11A2_ENST00000547688.1_Silent_p.K590K|SLC11A2_ENST00000547198.1_Intron|SLC11A2_ENST00000545993.2_Silent_p.K557K|SLC11A2_ENST00000541174.2_Silent_p.K561K|SLC11A2_ENST00000262052.5_Silent_p.K561K|SLC11A2_ENST00000262051.7_Intron|SLC11A2_ENST00000546743.1_Silent_p.K482K	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	0					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						TCCAGTGTTATTTAACGTAGC	0.478000													27	45					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113683157	113683157	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr11:113683157T>A	ENST00000003302.4	-	16	1881	c.1813A>T	c.(1813-1815)Atc>Ttc	p.I605F	USP28_ENST00000545540.1_Missense_Mutation_p.I480F|USP28_ENST00000544967.1_Missense_Mutation_p.I313F|USP28_ENST00000260188.5_Missense_Mutation_p.I605F	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	605					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TGATTATAGATATAGGCCCAA	0.453000													47	32					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30721046	30721046	+	Silent	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:30721046G>C	ENST00000262518.4	+	7	1231	c.846G>C	c.(844-846)ctG>ctC	p.L282L	SRCAP_ENST00000344771.4_Silent_p.L282L|SRCAP_ENST00000395059.2_Silent_p.L282L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	282					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CTTCTCGCCTGGATGATGAAG	0.567000													30	43					0	0	1	0	0
DUS1L	64118	broad.mit.edu	37	17	80019564	80019564	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:80019564C>T	ENST00000354321.7	-	6	1112	c.627G>A	c.(625-627)ggG>ggA	p.G209G	DUS1L_ENST00000306796.5_Silent_p.G209G			Q6P1R4	DUS1L_HUMAN	dihydrouridine synthase 1-like (S. cerevisiae)	209					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|endometrium(1)|lung(2)|ovary(1)|skin(1)	6	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			ACTGGATGTTCCCGTTAGCAA	0.657000													14	54					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128196	152128196	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:152128196C>T	ENST00000316073.3	-	3	1443	c.1379G>A	c.(1378-1380)aGt>aAt	p.S460N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	460	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						ATAGTGGGAACTCTGGCCTTG	0.512000													190	440					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150436497	150436497	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:150436497C>T	ENST00000389378.2	-	6	1045	c.457G>A	c.(457-459)Gag>Aag	p.E153K	TNIP1_ENST00000521591.1_Missense_Mutation_p.E153K|TNIP1_ENST00000524280.1_Missense_Mutation_p.E153K|TNIP1_ENST00000522226.1_Missense_Mutation_p.E153K|TNIP1_ENST00000518977.1_Missense_Mutation_p.E153K|TNIP1_ENST00000520931.1_Missense_Mutation_p.E100K|TNIP1_ENST00000523200.1_Missense_Mutation_p.E153K|TNIP1_ENST00000315050.7_Missense_Mutation_p.E153K|TNIP1_ENST00000523338.1_Missense_Mutation_p.E153K	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	153	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGCCGTCCTCACGGGGCAGG	0.682000													20	21					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92972595	92972595	+	Missense_Mutation	SNP	G	G	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:92972595G>T	ENST00000523629.1	-	12	2144	c.1690C>A	c.(1690-1692)Cct>Act	p.P564T	RUNX1T1_ENST00000422361.2_Missense_Mutation_p.P527T|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.P527T|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.P564T|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.P575T|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.P537T|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.P537T|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.P527T	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	564					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CTGACTGCAGGTGTGTCTCCC	0.622000													25	20					6.21321e-17	6.81727e-17	1	1	0
ACSM2B	348158	broad.mit.edu	37	16	20554565	20554565	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:20554565G>A	ENST00000329697.6	-	11	1469	c.1301C>T	c.(1300-1302)gCa>gTa	p.A434V	ACSM2B_ENST00000565322.1_Missense_Mutation_p.A355V|ACSM2B_ENST00000567001.1_Missense_Mutation_p.A434V|ACSM2B_ENST00000565232.1_Missense_Mutation_p.A434V	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	434					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						AATGTTGGCTGCTGTCTTGTC	0.488000													39	38					0	0	1	0	0
MTMR1	8776	broad.mit.edu	37	X	149867750	149867750	+	Missense_Mutation	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrX:149867750G>A	ENST00000445323.2	+	2	350	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K	MTMR1_ENST00000451863.2_Missense_Mutation_p.E77K|MTMR1_ENST00000542156.1_Missense_Mutation_p.E77K|MTMR1_ENST00000544228.1_Missense_Mutation_p.E77K|MTMR1_ENST00000541925.1_5'UTR|MTMR1_ENST00000370390.3_Missense_Mutation_p.E77K			Q13613	MTMR1_HUMAN	myotubularin related protein 1	77						plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					AGTGACATCAGAAAATGTGTC	0.363000													31	24					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577123	158577123	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr1:158577123A>G	ENST00000361284.1	+	1	895	c.895A>G	c.(895-897)Aca>Gca	p.T299A		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					GGCTATACAGACAGCTCTGAG	0.453000													31	154					0	0	1	0	0
SLC23A2	9962	broad.mit.edu	37	20	4880344	4880344	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr20:4880344G>A	ENST00000379333.1	-	6	731	c.339C>T	c.(337-339)tgC>tgT	p.C113C	SLC23A2_ENST00000424750.2_Silent_p.C113C|SLC23A2_ENST00000468355.1_5'UTR|SLC23A2_ENST00000338244.1_Silent_p.C113C	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	113					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TGCCGCTGAAGCATGTCAGGT	0.502000													40	88					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098800	178098800	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:178098800T>A	ENST00000397062.3	-	2	799	c.245A>T	c.(244-246)gAa>gTa	p.E82V	NFE2L2_ENST00000423513.1_Missense_Mutation_p.E66V|NFE2L2_ENST00000397063.4_Missense_Mutation_p.E66V|NFE2L2_ENST00000464747.1_Missense_Mutation_p.E66V|NFE2L2_ENST00000446151.2_Missense_Mutation_p.E66V	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	82					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E82G(3)|p.G81_F83delGEF(1)|p.E82V(1)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TGGGAGAAATTCACCTGTCTC	0.433000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			73	34					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													4	83					0	0	1	0	0
ZNF431	170959	broad.mit.edu	37	19	21366030	21366030	+	Silent	SNP	A	A	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:21366030A>T	ENST00000311048.7	+	5	1068	c.924A>T	c.(922-924)atA>atT	p.I308I	ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_3'UTR	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						CACATAAGATAATTCATACTG	0.393000													18	43					0	0	1	0	0
CARD14	79092	broad.mit.edu	37	17	78155327	78155327	+	Silent	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr17:78155327C>T	ENST00000573882.1	+	4	626	c.90C>T	c.(88-90)atC>atT	p.I30I	CARD14_ENST00000344227.2_Silent_p.I30I|CARD14_ENST00000570421.1_Silent_p.I30I			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	30	CARD.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCCACAGGATCGTACGCTGCA	0.677000													5	6					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449416	35449416	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:35449416C>T	ENST00000404801.1	-	4	1729	c.1343G>A	c.(1342-1344)cGg>cAg	p.R448Q	ZNF792_ENST00000605484.1_Missense_Mutation_p.R381Q	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CCCGTGAGGCCGCTCGCCAGT	0.502000													30	93					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104752302	104752302	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:104752302C>G	ENST00000334877.4	+	26	4507	c.3973C>G	c.(3973-3975)Caa>Gaa	p.Q1325E	KMT2E_ENST00000257745.4_Missense_Mutation_p.Q1367E|KMT2E_ENST00000334914.7_Missense_Mutation_p.Q422E|KMT2E_ENST00000311117.3_Missense_Mutation_p.Q1367E|SRPK2_ENST00000493638.1_Intron					lysine (K)-specific methyltransferase 2E																		AATTCCTGCTCAAGCACACGG	0.408000													40	87					0	0	1	0	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727462	25727462	+	Missense_Mutation	SNP	C	C	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:25727462C>T	ENST00000274764.2	+	1	326	c.326C>T	c.(325-327)gCt>gTt	p.A109V		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	109					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						GGAGAGCTGGCTAAACATGCT	0.522000													17	28					0	0	1	0	0
CSE1L	1434	broad.mit.edu	37	20	47707502	47707502	+	Missense_Mutation	SNP	A	A	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr20:47707502A>G	ENST00000262982.2	+	21	2431	c.2308A>G	c.(2308-2310)Atc>Gtc	p.I770V	CSE1L_ENST00000542325.1_Missense_Mutation_p.I553V|CSE1L_ENST00000469700.1_3'UTR|CSE1L_ENST00000396192.3_Missense_Mutation_p.I714V	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	770					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TAGGAAACAAATCTTCATTCT	0.284000													60	58					0	0	1	0	0
PML	5371	broad.mit.edu	37	15	74328212	74328212	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr15:74328212C>G	ENST00000268059.6	+	8	2506	c.2410C>G	c.(2410-2412)Cca>Gca	p.P804A	PML_ENST00000569965.1_Intron|PML_ENST00000564428.1_Intron|PML_ENST00000436891.3_3'UTR|PML_ENST00000354026.6_Missense_Mutation_p.P756A|PML_ENST00000395132.2_Intron|PML_ENST00000395135.3_Intron|PML_ENST00000435786.2_3'UTR|PML_ENST00000359928.4_Intron|PML_ENST00000565898.1_Intron|PML_ENST00000268058.3_Intron|PML_ENST00000563500.1_3'UTR	NM_033239.2|NM_033244.3	NP_150242.1|NP_150247.2	P29590	PML_HUMAN	promyelocytic leukemia	94					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						GGAAGCCTCTCCAATTACATT	0.607000			T	"""RARA, PAX5"""	"""APL, ALL"""								76	176					0	0	1	0	0
MGAT2	4247	broad.mit.edu	37	14	50088589	50088589	+	Silent	SNP	G	G	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:50088589G>A	ENST00000305386.2	+	1	1101	c.603G>A	c.(601-603)ccG>ccA	p.P201P	RP11-649E7.5_ENST00000555043.1_RNA	NM_002408.3	NP_002399.1	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	201					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)	11	all_epithelial(31;0.0021)|Breast(41;0.0124)					GAGACCTGCCGAAGAATGCCG	0.488000													169	95					0	0	1	0	0
CTGF	1490	broad.mit.edu	37	6	132270505	132270505	+	Missense_Mutation	SNP	T	T	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:132270505T>A	ENST00000367976.3	-	5	1149	c.949A>T	c.(949-951)Atg>Ttg	p.M317L		NM_001901.2	NP_001892.1	P29279	CTGF_HUMAN	connective tissue growth factor	317	CTCK.|Heparin-binding.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	13	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		ATGAACATCATGTTCTTCTTC	0.537000													38	66					0	0	1	0	0
AKAP7	9465	broad.mit.edu	37	6	131481297	131481297	+	Missense_Mutation	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr6:131481297C>G	ENST00000431975.2	+	3	348	c.250C>G	c.(250-252)Caa>Gaa	p.Q84E	AKAP7_ENST00000366358.2_3'UTR|AKAP7_ENST00000368123.4_Missense_Mutation_p.Q62E|AKAP7_ENST00000541650.1_Missense_Mutation_p.Q83E	NM_016377.3	NP_057461.2	O43687	AKA7A_HUMAN	A kinase (PRKA) anchor protein 7	0					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|stomach(1)	13	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		AAAAGATTATCAACCCAACTA	0.299000													28	40					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17449927	17449927	+	Silent	SNP	C	C	G			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr19:17449927C>G	ENST00000358792.7	+	5	813	c.756C>G	c.(754-756)ccC>ccG	p.P252P	GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000600625.1_Intron|GTPBP3_ENST00000324894.8_Intron|GTPBP3_ENST00000361619.5_Intron			Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	221					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						TTCTCTCACCCACAGCCGACA	0.627000													17	35					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140682872	140682872	+	Missense_Mutation	SNP	G	G	C			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr5:140682872G>C	ENST00000239451.4	-	1	740	c.561C>G	c.(559-561)ttC>ttG	p.F187L		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	187					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	AGCCACCAAAGAAAAAGAAAT	0.463000													25	67					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135596302	135596303	+	Frame_Shift_Ins	INS	-	-	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr2:135596302_135596303insA	ENST00000356140.5	+	1	186_187	c.50_51insA	c.(49-51)caafs	p.Q17fs	ACMSD_ENST00000283054.4_5'UTR|AC016725.4_ENST00000392929.2_RNA|ACMSD_ENST00000392928.1_5'UTR	NM_138326.2	NP_612199.2	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	17					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			endometrium(3)|large_intestine(4)|lung(6)|skin(1)	14				BRCA - Breast invasive adenocarcinoma(221;0.115)		TGGCCAGATCTAAAAAAGGTAA	0.347													12	38	---	---	---	---					
SENP7	57337	broad.mit.edu	37	3	101070484	101070484	+	Frame_Shift_Del	DEL	T	T	-			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:101070484delT	ENST00000394095.2	-	12	1688	c.1635delA	c.(1633-1635)aafs	p.K545fs	SENP7_ENST00000394091.1_Frame_Shift_Del_p.K381fs|SENP7_ENST00000348610.3_Frame_Shift_Del_p.K512fs|SENP7_ENST00000358203.3_Frame_Shift_Del_p.K381fs|SENP7_ENST00000394094.2_Frame_Shift_Del_p.K480fs|SENP7_ENST00000314261.7_Frame_Shift_Del_p.K479fs	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	545					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TCTTAATATATTTTTTTGTGA	0.219													9	42	---	---	---	---					
MFI2	4241	broad.mit.edu	37	3	196751281	196751282	+	Frame_Shift_Ins	INS	-	-	CGCCT			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr3:196751281_196751282insCGCCT	ENST00000296350.5	-	4	492_493	c.379_380insAGGCG	c.(379-381)gaafs	p.E127fs	MFI2_ENST00000296351.4_Frame_Shift_Ins_p.E127fs	NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	127	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GCAGGACTTCACGCCTTTCAGG	0.629													26	104	---	---	---	---					
GTF2IRD2P1	401375	broad.mit.edu	37	7	72685509	72685511	+	RNA	DEL	AAT	AAT	-			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:72685509_72685511delAAT	ENST00000425256.1	-	0	120					NR_002164.1																						aaaaaaaaaaaatagaaTTAATG	0.473													8	107	---	---	---	---					
CYP51A1	1595	broad.mit.edu	37	7	91752493	91752494	+	Frame_Shift_Ins	INS	-	-	T			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr7:91752493_91752494insT	ENST00000003100.8	-	7	1191_1192	c.1026_1027insA	c.(1024-1029)aagttafs	p.L343fs	CYP51A1_ENST00000450723.1_Frame_Shift_Ins_p.L238fs|LRRD1_ENST00000422722.1_5'UTR	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	337					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	TCTAAATAACATTTTTTTTGAA	0.396													78	178	---	---	---	---					
ADAM28	10863	broad.mit.edu	37	8	24167472	24167473	+	Frame_Shift_Ins	INS	-	-	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:24167472_24167473insA	ENST00000265769.4	+	3	326_327	c.216_217insA	c.(214-219)ttaaaafs	p.LK72fs	RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_5'UTR|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000437154.2_Frame_Shift_Ins_p.LK72fs|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000397649.3_5'UTR	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	72					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding	p.N75fs*15(1)		central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGCTTTATTTGAAAAAAAACAA	0.332													22	29	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142483606	142483606	+	RNA	DEL	G	G	-			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr8:142483606delG	ENST00000430863.1	-	0	1845					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GAGGAAGGGCGGGGGGGAGTG	0.657													2	4	---	---	---	---					
KDM5A	5927	broad.mit.edu	37	12	416981	416981	+	Frame_Shift_Del	DEL	G	G	-			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:416981delG	ENST00000399788.2	-	23	3931	c.3569delC	c.(3568-3570)ctfs	p.P1190fs	KDM5A_ENST00000382815.4_Frame_Shift_Del_p.P1190fs	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1190			P -> A (in dbSNP:rs2229353).		chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TTTAGGAAGAGGAACACAGCT	0.448			T	NUP98	AML								37	192	---	---	---	---					
TNFRSF1A	7132	broad.mit.edu	37	12	6438752	6438752	+	Frame_Shift_Del	DEL	T	T	-			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr12:6438752delT	ENST00000162749.2	-	10	1393	c.1094delA	c.(1093-1095)acfs	p.N365fs	TNFRSF1A_ENST00000540022.1_Frame_Shift_Del_p.N322fs	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	365	Death.				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						CGGGGGCACGTTCTCCACCAC	0.731													14	23	---	---	---	---					
BAZ1A	11177	broad.mit.edu	37	14	35331380	35331381	+	Frame_Shift_Ins	INS	-	-	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:35331380_35331381insA	ENST00000360310.1	-	3	828_829	c.261_262insT	c.(259-264)atcagtfs	p.S88fs	BAZ1A_ENST00000382422.2_Frame_Shift_Ins_p.S88fs|BAZ1A_ENST00000358716.4_Frame_Shift_Ins_p.S88fs|BAZ1A_ENST00000553853.1_5'UTR	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	88	Required for association with the CHRAC1/POLE3 complex.|Required for interaction with NCOR1.|WAC.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TATAAAACTGGAATAATTAGTG	0.406													586	149	---	---	---	---					
LINC00639	283547	broad.mit.edu	37	14	39304293	39304296	+	RNA	DEL	CACA	CACA	-	rs5808014	by1000genomes	TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:39304293_39304296delCACA	ENST00000553932.1	-	0	3985																											CGCCCTGCTCcacacacacacaca	0.475													3	3	---	---	---	---					
DNAAF2	55172	broad.mit.edu	37	14	50092638	50092639	+	Frame_Shift_Ins	INS	-	-	A			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr14:50092638_50092639insA	ENST00000298292.8	-	3	2215_2216	c.2135_2136insT	c.(2134-2136)agcfs	p.S712fs	DNAAF2_ENST00000406043.3_Frame_Shift_Ins_p.S664fs	NM_018139.2	NP_060609.2	Q9NVR5	KTU_HUMAN	dynein, axonemal, assembly factor 2	712					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm				kidney(1)|lung(4)	5						CTTTAACTGCTATAGATGAATC	0.342													20	97	---	---	---	---					
SOX8	30812	broad.mit.edu	37	16	1032188	1032190	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chr16:1032188_1032190delGCG	ENST00000293894.3	+	1	381_383	c.266_268delGCG	c.(265-270)cgc>c	p.RG89del		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	89					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus		p.G94delG(1)		central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				ATGCCGGTgcgcggcggcggcgg	0.729													2	4	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149638187	149638187	+	Frame_Shift_Del	DEL	A	A	-			TCGA-T3-A92N-01A-11D-A391-08	TCGA-T3-A92N-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40005278-5569-44a5-94a2-9311946aa7ca	8e5216b7-93fa-440f-bf1a-c304f42b98da	g.chrX:149638187delA	ENST00000370401.2	+	4	652	c.342delA	c.(340-342)acfs	p.T114fs	MAMLD1_ENST00000426613.2_Frame_Shift_Del_p.T89fs|MAMLD1_ENST00000262858.5_Frame_Shift_Del_p.T114fs|MAMLD1_ENST00000432680.2_Frame_Shift_Del_p.T89fs|MAMLD1_ENST00000468306.1_3'UTR			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	114					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCATTGACAATAAATCCTA	0.493													74	22	---	---	---	---					
