Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BEGAIN	57596	broad.mit.edu	37	14	101012917	101012917	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr14:101012917C>A	ENST00000443071.2	-	2	242	c.97G>T	c.(97-99)Gac>Tac	p.D33Y	BEGAIN_ENST00000556751.1_5'UTR|BEGAIN_ENST00000355173.2_Missense_Mutation_p.D33Y|BEGAIN_ENST00000554747.1_5'UTR	NM_001159531.1	NP_001153003.1	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	33						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				CGCGTGGAGTCGAACTCGGTC	0.672000													9	99					1.11149e-13	1.22127e-13	1	1	0
ZNF217	7764	broad.mit.edu	37	20	52188372	52188372	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:52188372G>C	ENST00000371471.2	-	5	3483	c.3058C>G	c.(3058-3060)Caa>Gaa	p.Q1020E	ZNF217_ENST00000302342.3_Missense_Mutation_p.Q1020E|RP4-724E16.2_ENST00000424252.1_RNA			O75362	ZN217_HUMAN	zinc finger protein 217	1020					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GATAAGTGTTGATATGACACA	0.299000													19	125					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166755204	166755204	+	Missense_Mutation	SNP	C	C	T	rs142022626	byFrequency	TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:166755204C>T	ENST00000243344.7	-	22	3079	c.2942G>A	c.(2941-2943)cGt>cAt	p.R981H		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	981						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						ACCTGGCTTACGTTCTAAAAG	0.378000													21	64					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108300312	108300312	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:108300312C>T	ENST00000295746.8	-	5	575	c.499G>A	c.(499-501)Gca>Aca	p.A167T	KIAA1524_ENST00000491772.1_Missense_Mutation_p.A8T|KIAA1524_ENST00000487834.1_5'UTR	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	167						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CAAAGATTTGCCAATAATCCT	0.294000													4	86					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38197164	38197164	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:38197164G>C	ENST00000373048.4	-	7	1581	c.1582C>G	c.(1582-1584)Cag>Gag	p.Q528E	EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000330210.7_Missense_Mutation_p.Q23E|EPHA10_ENST00000540011.1_Missense_Mutation_p.Q23E|EPHA10_ENST00000427468.2_Missense_Mutation_p.Q528E	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	528	Fibronectin type-III 2.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCCCGGATCTGAAAGACGTAG	0.597000													17	151					0	0	1	0	0
FBXL5	26234	broad.mit.edu	37	4	15613901	15613901	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr4:15613901C>T	ENST00000341285.3	-	10	2111	c.1987G>A	c.(1987-1989)Gac>Aac	p.D663N	FBXL5_ENST00000412094.2_Missense_Mutation_p.D646N|FBXL5_ENST00000382358.4_Missense_Mutation_p.D537N	NM_001193534.1|NM_001193535.1|NM_012161.3	NP_001180463.1|NP_001180464.1|NP_036293.1	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5	663					iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13						TTAATGTTGTCACAGTAGTAA	0.333000													18	109					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25144710	25144710	+	RNA	SNP	A	A	G	rs71218558	by1000genomes	TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr13:25144710A>G	ENST00000453498.1	+	0	251																											GATGTGTTTAACACAGCCCCT	0.398000													3	42					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563856	140563856	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:140563856G>A	ENST00000361016.2	+	1	2877	c.1722G>A	c.(1720-1722)gaG>gaA	p.E574E		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		574	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGCACTGAGCTGGTGCCCC	0.697000													56	65					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71730018	71730018	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:71730018G>A	ENST00000393695.3	-	10	924	c.593C>T	c.(592-594)tCa>tTa	p.S198L	NUMA1_ENST00000351960.6_Missense_Mutation_p.S198L|RP11-849H4.4_ENST00000502284.1_RNA|NUMA1_ENST00000358965.6_Missense_Mutation_p.S198L	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	198					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						TGGAGAACCTGAGAGAAAGCT	0.517000			T	RARA	APL								18	104					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59224633	59224633	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr15:59224633C>G	ENST00000380516.2	-	2	259	c.172G>C	c.(172-174)Gag>Cag	p.E58Q	SLTM_ENST00000536328.1_Intron|SLTM_ENST00000557950.1_5'UTR	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	58					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCTCCTTCCTCTTCAATAGCC	0.318000													18	155					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219922253	219922253	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:219922253C>A	ENST00000295731.5	-	2	478	c.479G>T	c.(478-480)cGc>cTc	p.R160L		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	160					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATACTTATTGCGGTCGCGGTC	0.622000													9	33					2.17888e-05	2.30857e-05	1	1	0
ZNF606	80095	broad.mit.edu	37	19	58490485	58490485	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:58490485G>C	ENST00000341164.4	-	7	2183	c.1563C>G	c.(1561-1563)ttC>ttG	p.F521L	ZNF606_ENST00000536132.1_Missense_Mutation_p.F431L	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AGCTCCAGCTGAATGATTTCC	0.413000													8	100					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223991102	223991102	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:223991102G>A	ENST00000391878.2	-	8	1083	c.315C>T	c.(313-315)ctC>ctT	p.L105L	TP53BP2_ENST00000343537.7_Silent_p.L234L	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	228					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		CAGCCAGGACGAGCTCCCTCT	0.448000													25	102					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155102337	155102337	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:155102337C>T	ENST00000392825.3	+	7	1266	c.699C>T	c.(697-699)gtC>gtT	p.V233V	GALNT13_ENST00000409237.1_Silent_p.V233V	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	233						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						AAACGGTTGTCTGCCCTATCA	0.348000													15	97					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													3	18					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92472378	92472378	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr14:92472378C>G	ENST00000267622.4	-	11	2315	c.1942G>C	c.(1942-1944)Gaa>Caa	p.E648Q		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	648					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		ACTTCAGCTTCTCTTTCTTTA	0.294000			T	PDGFRB	AML								4	71					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885943	180885943	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:180885943G>A	ENST00000367588.4	+	2	759	c.704G>A	c.(703-705)aGc>aAc	p.S235N		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	235										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CACATTCCCAGCCCAAGGACA	0.577000													29	271					0	0	1	0	0
DCAKD	79877	broad.mit.edu	37	17	43111349	43111349	+	Silent	SNP	A	A	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:43111349A>G	ENST00000310604.4	-	4	709	c.378T>C	c.(376-378)agT>agC	p.S126S	DCAKD_ENST00000342350.5_Intron|DCAKD_ENST00000452796.2_Intron|DCAKD_ENST00000588499.1_Intron|DCAKD_ENST00000588295.1_5'UTR			Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	0	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(2)|skin(1)	6		Prostate(33;0.155)				ttctcattaaactgtcagcct	0.493000													3	22					0	0	1	0	0
CSPG5	10675	broad.mit.edu	37	3	47618421	47618421	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:47618421C>T	ENST00000383738.2	-	2	3193	c.1095G>A	c.(1093-1095)cgG>cgA	p.R365R	CSPG5_ENST00000456150.1_Silent_p.R227R|CSPG5_ENST00000264723.4_Silent_p.R365R	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	365					cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		AGCCGTTATGCCGCACAAAGC	0.627000													4	160					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57896426	57896426	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr4:57896426C>A	ENST00000381227.1	+	25	3709	c.3296C>A	c.(3295-3297)gCa>gAa	p.A1099E	POLR2B_ENST00000431623.2_Missense_Mutation_p.A1024E|POLR2B_ENST00000441246.2_Missense_Mutation_p.A1092E|POLR2B_ENST00000314595.5_Missense_Mutation_p.A1099E			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	1099					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					GCCCATGGAGCAGCCCAGTTT	0.393000													40	119					1.44828e-35	1.62135e-35	1	1	0
ZNF518A	9849	broad.mit.edu	37	10	97917314	97917314	+	RNA	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr10:97917314C>T	ENST00000534948.1	+	0	2092							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AACGCTAGTTCAGGTTTCATG	0.408000													8	61					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125033892	125033892	+	Missense_Mutation	SNP	C	C	T	rs150164383	by1000genomes	TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:125033892C>T	ENST00000522917.1	+	17	2322	c.2116C>T	c.(2116-2118)Cgc>Tgc	p.R706C	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.R706C	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	706						integral to membrane		p.R706S(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGAAAAAATCCGCTTTCTTGT	0.428000													29	112					0	0	1	0	0
TNFAIP8L2	79626	broad.mit.edu	37	1	151131291	151131291	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:151131291G>C	ENST00000368910.3	+	2	244	c.118G>C	c.(118-120)Gat>Cat	p.D40H		NM_024575.4	NP_078851.2	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 2	40					innate immune response					lung(1)|skin(2)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGAGGTGCTAGATGAGCTCTA	0.557000													12	68					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16694713	16694713	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:16694713C>T	ENST00000513610.1	-	27	4021	c.3567G>A	c.(3565-3567)atG>atA	p.M1189I	MYO10_ENST00000515803.1_Missense_Mutation_p.M528I|MYO10_ENST00000274203.9_Missense_Mutation_p.M546I|MYO10_ENST00000505695.1_Missense_Mutation_p.M528I|MYO10_ENST00000427430.2_Missense_Mutation_p.M546I	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1189					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						TCCAAGAGTTCATCAGGCCAC	0.517000													14	139					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83590889	83590889	+	Missense_Mutation	SNP	T	T	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr7:83590889T>A	ENST00000265362.3	-	17	2428	c.2114A>T	c.(2113-2115)gAc>gTc	p.D705V	SEMA3A_ENST00000436949.1_Missense_Mutation_p.D705V	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	705					axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CTGCATGAAGTCTCTGTACCA	0.448000													14	113					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6638722	6638722	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:6638722G>C	ENST00000333172.6	+	6	1797	c.1604G>C	c.(1603-1605)aGa>aCa	p.R535T	TAS1R1_ENST00000328191.4_Missense_Mutation_p.D424H|TAS1R1_ENST00000351136.3_Missense_Mutation_p.R281T	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	535					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GACCTCTACAGATGCCAGCCT	0.537000													4	68					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39847146	39847146	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr6:39847146C>A	ENST00000538976.1	+	14	1920	c.1738C>A	c.(1738-1740)Ccc>Acc	p.P580T	DAAM2_ENST00000398904.2_Missense_Mutation_p.P580T|DAAM2_ENST00000274867.4_Missense_Mutation_p.P580T	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	580	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					CATGGGCCTGCCCCTCCCTCA	0.662000													5	80					1.23904e-05	1.32065e-05	1	1	0
LRP4	4038	broad.mit.edu	37	11	46911006	46911006	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:46911006C>A	ENST00000378623.1	-	16	2413	c.2171G>T	c.(2170-2172)tGc>tTc	p.C724F		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	724	EGF-like 3.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		GCCAGTGGGGCAGGCACAGGT	0.607000											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	94					4.3838e-07	4.72919e-07	1	1	0
GRIK1	2897	broad.mit.edu	37	21	31045417	31045417	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr21:31045417C>A	ENST00000399914.1	-	4	1133	c.612G>T	c.(610-612)caG>caT	p.Q204H	GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000389125.3_Missense_Mutation_p.Q204H|GRIK1_ENST00000309434.7_Missense_Mutation_p.Q204H|GRIK1_ENST00000399909.1_Missense_Mutation_p.Q204H|GRIK1_ENST00000389124.2_Missense_Mutation_p.Q204H|GRIK1_ENST00000399907.1_Missense_Mutation_p.Q204H|GRIK1_ENST00000399913.1_Missense_Mutation_p.Q204H|GRIK1_ENST00000327783.4_Missense_Mutation_p.Q204H|GRIK1_ENST00000535441.1_Missense_Mutation_p.Q204H			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	204					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CAGAGGGCAGCTGGCGGATTT	0.413000													26	138					3.7963e-18	4.22339e-18	1	1	0
TNR	7143	broad.mit.edu	37	1	175365923	175365923	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:175365923G>A	ENST00000367674.1	-	5	1705	c.997C>T	c.(997-999)Cga>Tga	p.R333*	TNR_ENST00000263525.2_Nonsense_Mutation_p.R333*	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	333	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CCAGCCACTCGCAAGTCCTCT	0.572000													5	200					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70446125	70446125	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:70446125G>A	ENST00000310961.5	+	10	1094	c.676G>A	c.(676-678)Gtg>Atg	p.V226M	LRRC7_ENST00000035383.5_Missense_Mutation_p.V221M|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	221						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TGCATTACAAGTGTTACCTGG	0.343000													31	124					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1905420	1905420	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:1905420G>A	ENST00000518288.1	+	30	4261	c.4098G>A	c.(4096-4098)ctG>ctA	p.L1366L	ARHGEF10_ENST00000262112.6_Silent_p.L1338L|ARHGEF10_ENST00000398564.1_Silent_p.L1367L|ARHGEF10_ENST00000520359.1_Silent_p.L1304L|ARHGEF10_ENST00000349830.3_Silent_p.L1342L			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	1367					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TCCCTCTGCTGAATATATAAG	0.587000													5	19					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58489968	58489968	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:58489968G>A	ENST00000341164.4	-	7	2700	c.2080C>T	c.(2080-2082)Cac>Tac	p.H694Y	ZNF606_ENST00000536132.1_Missense_Mutation_p.H604Y	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	694					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H694N(2)|p.H694Y(1)		NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		GCAATGAGGTGAGAACTACAG	0.418000													7	131					0	0	1	0	0
ACOT8	10005	broad.mit.edu	37	20	44473041	44473041	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:44473041C>G	ENST00000217455.4	-	4	597	c.507G>C	c.(505-507)aaG>aaC	p.K169N		NM_005469.3	NP_005460.2	O14734	ACOT8_HUMAN	acyl-CoA thioesterase 8	169					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			kidney(2)|large_intestine(3)|lung(4)|skin(1)	10		Myeloproliferative disorder(115;0.0122)				ATGGGTACCTCTTTTGGAGGT	0.557000													8	74					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54849515	54849515	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:54849515G>C	ENST00000333896.5	+	8	1301	c.916G>C	c.(916-918)Gaa>Caa	p.E306Q	SPTBN1_ENST00000356805.4_Missense_Mutation_p.E319Q	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	319					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GGAATGGATTGAACAAACCAT	0.413000													11	110					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774518	40774518	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr9:40774518C>T	ENST00000602553.1	-	5	1051	c.757G>A	c.(757-759)Gat>Aat	p.D253N	ZNF658_ENST00000441795.1_Missense_Mutation_p.D251N|ZNF658_ENST00000377626.3_Missense_Mutation_p.D253N			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	253					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GTGATTTTATCAAAGTTTTTT	0.353000													42	248					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136615495	136615495	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:136615495G>A	ENST00000264156.2	-	10	1502	c.1442C>T	c.(1441-1443)aCc>aTc	p.T481I	MCM6_ENST00000492091.1_Intron	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	481	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GATGGATATGGTCTGCTGTTC	0.408000													20	138					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53030949	53030949	+	Silent	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:53030949C>G	ENST00000276480.7	-	24	3491	c.2808G>C	c.(2806-2808)ctG>ctC	p.L936L		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	936						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGGATTCATTCAGTTCCTTTA	0.313000													12	163					0	0	1	0	0
HNMT	3176	broad.mit.edu	37	2	138771380	138771380	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:138771380G>A	ENST00000280097.3	+	6	741	c.559G>A	c.(559-561)Gga>Aga	p.G187R	HNMT_ENST00000485653.1_3'UTR|HNMT_ENST00000410115.1_Missense_Mutation_p.G187R	NM_006895.2	NP_008826.1	P50135	HNMT_HUMAN	histamine N-methyltransferase	187					respiratory gaseous exchange	cytoplasm	histamine N-methyltransferase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.125)	Amodiaquine(DB00613)|Histamine Phosphate(DB00667)|Quinacrine(DB01103)	GAAAAAGTACGGATCACGCTT	0.453000													9	51					0	0	1	0	0
EIF4A2	1974	broad.mit.edu	37	3	186504028	186504028	+	Missense_Mutation	SNP	A	A	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:186504028A>T	ENST00000323963.5	+	6	657	c.593A>T	c.(592-594)tAt>tTt	p.Y198F	EIF4A2_ENST00000356531.5_Missense_Mutation_p.Y103F|EIF4A2_ENST00000440191.2_Missense_Mutation_p.Y199F			Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	198	Helicase ATP-binding.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|urinary_tract(1)	28	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		GATCAAATCTATGAGATTTTC	0.363000			T	BCL6	NHL								5	68					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37547206	37547206	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:37547206C>T	ENST00000299824.1	+	11	1790	c.1601C>T	c.(1600-1602)tCg>tTg	p.S534L	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.S492L	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	534					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				AATGGGACCTCGGTATATTAC	0.582000													9	57					0	0	1	0	0
ZNF699	374879	broad.mit.edu	37	19	9408150	9408150	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:9408150C>G	ENST00000591998.1	-	5	520	c.292G>C	c.(292-294)Gag>Cag	p.E98Q	ZNF699_ENST00000308650.3_Missense_Mutation_p.E98Q			Q32M78	ZN699_HUMAN	zinc finger protein 699	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGTTGAGTCTCAAAACCTGAA	0.338000													15	146					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66416401	66416401	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:66416401G>A	ENST00000448504.2	+	12	2171	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K	ARSG_ENST00000452479.2_Missense_Mutation_p.E295K|ARSG_ENST00000582154.1_3'UTR|RP11-120M18.2_ENST00000592030.1_RNA	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	459					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTTCAACCTGGAAGACGATAC	0.562000													7	71					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201763688	201763688	+	Nonsense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:201763688C>G	ENST00000367296.4	+	15	3920	c.3500C>G	c.(3499-3501)tCa>tGa	p.S1167*	NAV1_ENST00000367297.4_Nonsense_Mutation_p.S1159*|NAV1_ENST00000295624.6_Nonsense_Mutation_p.S1167*|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367295.1_Nonsense_Mutation_p.S776*|NAV1_ENST00000367300.3_Nonsense_Mutation_p.S1110*|NAV1_ENST00000367302.1_Nonsense_Mutation_p.S1123*|NAV1_ENST00000469130.1_3'UTR	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1167					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CTTAATGCCTCAGAAACCACA	0.468000													8	77					0	0	1	0	0
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3593925	3593925	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:3593925G>A	ENST00000550383.1	-	4	598	c.410C>T	c.(409-411)gCt>gTt	p.A137V	P2RX5_ENST00000552050.1_Missense_Mutation_p.A77V|P2RX5_ENST00000552276.1_Missense_Mutation_p.A137V|P2RX5_ENST00000225328.5_Missense_Mutation_p.A137V|P2RX5_ENST00000550772.1_5'UTR|P2RX5_ENST00000345901.3_Missense_Mutation_p.A113V|P2RX5_ENST00000547178.1_Missense_Mutation_p.A137V|P2RX5_ENST00000435558.1_Missense_Mutation_p.A137V|P2RX5_ENST00000551178.1_Missense_Mutation_p.A113V																							CGCTTCCCCAGCGTGGCAGTC	0.647000													4	75					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29670383	29670383	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr12:29670383G>A	ENST00000256062.5	-	14	2295	c.1822C>T	c.(1822-1824)Cag>Tag	p.Q608*	TMTC1_ENST00000552618.1_Nonsense_Mutation_p.Q740*|TMTC1_ENST00000539277.1_Nonsense_Mutation_p.Q716*|TMTC1_ENST00000551659.1_Nonsense_Mutation_p.Q778*|TMTC1_ENST00000319685.8_5'UTR	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	716						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					AGCTCCCTCTGAGAAGGCTGA	0.512000													10	117					0	0	1	0	0
IFT52	51098	broad.mit.edu	37	20	42264628	42264628	+	Missense_Mutation	SNP	C	C	T	rs140986312		TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:42264628C>T	ENST00000373030.3	+	11	1116	c.986C>T	c.(985-987)aCg>aTg	p.T329M	IFT52_ENST00000373039.4_Missense_Mutation_p.T329M	NM_016004.2	NP_057088.2	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog (Chlamydomonas)	329						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CAGTTTGAGACGCCGCTGCCA	0.527000													4	70					0	0	1	0	0
MTX1	4580	broad.mit.edu	37	1	155180166	155180166	+	Silent	SNP	G	G	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:155180166G>T	ENST00000368376.3	+	2	664	c.558G>T	c.(556-558)ctG>ctT	p.L186L	MTX1_ENST00000316721.4_Silent_p.L186L|MTX1_ENST00000481771.1_3'UTR	NM_002455.3	NP_002446.2	Q13505	MTX1_HUMAN	metaxin 1	186					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GTGCTCCACTGAAGGTACACA	0.517000													22	140					2.39556e-15	2.64851e-15	1	1	0
CLASP1	23332	broad.mit.edu	37	2	122202539	122202539	+	Splice_Site	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:122202539C>A	ENST00000397587.3	-	20	2302		c.e20-1		CLASP1_ENST00000409078.3_Intron|CLASP1_ENST00000263710.4_Intron|CLASP1_ENST00000545861.1_Splice_Site|CLASP1_ENST00000541377.1_Intron|CLASP1_ENST00000541859.1_Intron|CLASP1_ENST00000455322.2_Intron	NM_001142273.1|NM_001142274.1	NP_001135745.1|NP_001135746.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1						axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					GTAGTACCATCTTTAAGCAAA	0.388000													5	20					0.000602214	0.000619619	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139209782	139209782	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:139209782G>T	ENST00000395297.1	-	8	970	c.800C>A	c.(799-801)cCa>cAa	p.P267Q		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	267										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGGCAGCTCTGGGATGTCCCG	0.622000										HNSCC(54;0.14)			7	84					2.0095e-06	2.15476e-06	1	1	0
C6orf118	168090	broad.mit.edu	37	6	165711543	165711543	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr6:165711543C>T	ENST00000543069.1	-	5	1253	c.672G>A	c.(670-672)acG>acA	p.T224T	C6orf118_ENST00000230301.8_Silent_p.T328T			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	328										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCATGTCCGCCGTCTTCACCG	0.607000													12	45					0	0	1	0	0
BLOC1S4	55330	broad.mit.edu	37	4	6718341	6718341	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr4:6718341C>G	ENST00000320776.3	+	1	500	c.405C>G	c.(403-405)atC>atG	p.I135M		NM_018366.2	NP_060836.1			biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino																		ACAGCAGGATCGACCGGCTGG	0.701000													3	20					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276466	152276466	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:152276466C>T	ENST00000368799.1	-	3	10931	c.10896G>A	c.(10894-10896)caG>caA	p.Q3632Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3632	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTGCTGACTGCTGGTGGT	0.557000									Ichthyosis				69	1085					0	0	1	0	0
AAGAB	79719	broad.mit.edu	37	15	67524184	67524184	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr15:67524184G>A	ENST00000261880.5	-	5	607	c.503C>T	c.(502-504)gCc>gTc	p.A168V	AAGAB_ENST00000561452.1_Missense_Mutation_p.A59V|AAGAB_ENST00000542650.1_Missense_Mutation_p.A59V	NM_001271885.1|NM_001271886.1|NM_024666.3	NP_001258814.1|NP_001258815.1|NP_078942.3	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin binding protein	168					protein transport	cytoplasm				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9						CCACACATTGGCATTCAGGGC	0.368000													24	411					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43207085	43207085	+	Nonsense_Mutation	SNP	T	T	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr18:43207085T>A	ENST00000255226.6	+	4	1310	c.494T>A	c.(493-495)tTa>tAa	p.L165*	SLC14A2_ENST00000586448.1_Nonsense_Mutation_p.L165*	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	165						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTCTCGACCTTAACAGCTCTC	0.512000													21	136					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21375252	21375252	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr12:21375252G>C	ENST00000256958.2	+	13	1797	c.1701G>C	c.(1699-1701)ttG>ttC	p.L567F		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	567					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	AACCTGAATTGAAATCACTTG	0.264000													6	80					0	0	1	0	0
CYP2R1	120227	broad.mit.edu	37	11	14902075	14902075	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:14902075C>T	ENST00000334636.5	-	3	653	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K	CYP2R1_ENST00000532378.1_Intron|CYP2R1_ENST00000526489.1_5'UTR	NM_024514.4	NP_078790.2	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R, polypeptide 1	203					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	TCGGTGTCTTCATAAGTGAAT	0.363000													16	73					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130363878	130363878	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr6:130363878G>A	ENST00000529410.1	+	5	513	c.34G>A	c.(34-36)Gag>Aag	p.E12K	L3MBTL3_ENST00000368136.2_Missense_Mutation_p.E12K|L3MBTL3_ENST00000533560.1_Missense_Mutation_p.E12K|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.E12K|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.E12K|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.E12K			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	12					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		AAGTGGTCAAGAGTTTGATGT	0.378000													14	81					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657830	72657830	+	RNA	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr7:72657830G>C	ENST00000425256.1	-	0	2081					NR_002164.1																						gacgatttgggagtgtccttg	0.507000													35	337					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238878	6238878	+	Silent	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:6238878G>C	ENST00000265978.4	-	9	2338	c.1980C>G	c.(1978-1980)gcC>gcG	p.A660A	FAM160A2_ENST00000449352.2_Silent_p.A646A|FAM160A2_ENST00000524416.1_Silent_p.A646A	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	646					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GAACCTTCTTGGCCCCCTCAG	0.677000													6	86					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810842	106810842	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:106810842C>T	ENST00000526355.1	-	4	1018	c.550G>A	c.(550-552)Gag>Aag	p.E184K	GUCY1A2_ENST00000347596.2_Missense_Mutation_p.E184K|GUCY1A2_ENST00000282249.2_Missense_Mutation_p.E184K	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	184					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CTCTCATTCTCATGAAAGCAT	0.363000													12	92					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540767	55540767	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:55540767C>G	ENST00000220676.1	+	4	4473	c.4325C>G	c.(4324-4326)cCa>cGa	p.P1442R		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1442					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATGGAAGAACCACGGACTTCT	0.343000													22	102					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94655540	94655540	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:94655540G>T	ENST00000260526.6	-	13	1563	c.1381C>A	c.(1381-1383)Caa>Aaa	p.Q461K	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	461					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CTGTACTCTTGGCCTGGGTCA	0.398000													13	105					0.00244969	0.00250601	1	1	0
GCLC	2729	broad.mit.edu	37	6	53374046	53374046	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr6:53374046C>T	ENST00000229416.6	-	7	1239	c.756G>A	c.(754-756)gtG>gtA	p.V252V		NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	252					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CTTGGAATGTCACCTGTTTAA	0.413000													11	87					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195512843	195512843	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:195512843C>T	ENST00000463781.3	-	2	6067	c.5608G>A	c.(5608-5610)Gcc>Acc	p.A1870T	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.A1870T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	628					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGAGAGGTGGCGTGACCTGTG	0.562000													3	15					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639282	6639282	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:6639282G>C	ENST00000333172.6	+	6	2357	c.2164G>C	c.(2164-2166)Gag>Cag	p.E722Q	TAS1R1_ENST00000328191.4_3'UTR|TAS1R1_ENST00000351136.3_Missense_Mutation_p.E468Q	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	722					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TGAGTGCACAGAGACCAACTC	0.567000													8	53					0	0	1	0	0
SLC7A11	23657	broad.mit.edu	37	4	139100509	139100509	+	Missense_Mutation	SNP	G	G	A	rs149003210		TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr4:139100509G>A	ENST00000280612.5	-	11	1585	c.1306C>T	c.(1306-1308)Ctc>Ttc	p.L436F		NM_014331.3	NP_055146.1	Q9UPY5	XCT_HUMAN	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	436					blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)	18	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	ACCATGAAGAGGCATGTGAAG	0.448000													35	62					0	0	1	0	0
NPM1	4869	broad.mit.edu	37	5	170819713	170819713	+	Splice_Site	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:170819713G>A	ENST00000296930.5	+	5	653		c.e5-1		NPM1_ENST00000393820.2_Splice_Site|NPM1_ENST00000517671.1_Splice_Site|NPM1_ENST00000351986.6_Splice_Site	NM_002520.6	NP_002511.1	P06748	NPM_HUMAN	nucleophosmin (nucleolar phosphoprotein B23, numatrin)						anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4261)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	4269	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTGTATTTTAGCTGTGGAGGA	0.383000			"""T, F """	"""ALK, RARA, MLF1"""	"""NHL, APL, AML"""								5	22					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99725295	99725295	+	Splice_Site	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:99725295C>T	ENST00000393483.3	-	7	1055		c.e7+1		TSGA10_ENST00000355053.4_Splice_Site|TSGA10_ENST00000539964.1_Splice_Site|TSGA10_ENST00000410001.1_Splice_Site|TSGA10_ENST00000542655.1_Splice_Site|TSGA10_ENST00000478090.1_Splice_Site	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10						spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TGTAAGTTTACCTGTTCATAA	0.323000													21	48					0	0	1	0	0
AP2M1	1173	broad.mit.edu	37	3	183899568	183899568	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:183899568C>A	ENST00000382456.3	+	7	1100	c.786C>A	c.(784-786)agC>agA	p.S262R	AP2M1_ENST00000439647.1_Missense_Mutation_p.S262R|AP2M1_ENST00000292807.5_Missense_Mutation_p.S264R|EIF2B5_ENST00000444495.1_Intron|AP2M1_ENST00000411763.2_Missense_Mutation_p.S289R|AP2M1_ENST00000461733.1_3'UTR	NM_001025205.1	NP_001020376.1	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	264	MHD.				axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity			endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	18	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCAGCATCAGCTTTATCCCGC	0.557000													4	94					0.000602214	0.000619619	1	1	0
ZNF606	80095	broad.mit.edu	37	19	58490065	58490065	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:58490065G>A	ENST00000341164.4	-	7	2603	c.1983C>T	c.(1981-1983)ttC>ttT	p.F661F	ZNF606_ENST00000536132.1_Silent_p.F571F	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AGCTCTGACTGAAGGATTTTC	0.408000													16	123					0	0	1	0	0
GCLC	2729	broad.mit.edu	37	6	53374003	53374003	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr6:53374003C>T	ENST00000229416.6	-	7	1282	c.799G>A	c.(799-801)Gat>Aat	p.D267N		NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	267					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	GCCAACTGATCATAAAGGTAT	0.358000													14	104					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732769	179732769	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:179732769G>A	ENST00000420890.2	-	16	2675	c.2558C>T	c.(2557-2559)tCa>tTa	p.S853L	CCDC141_ENST00000295723.5_Missense_Mutation_p.S278L	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	278	Ig-like.						protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CTGCACTGATGAGATGATGTC	0.498000													13	76					0	0	1	0	0
GDI1	2664	broad.mit.edu	37	X	153670499	153670499	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chrX:153670499G>T	ENST00000447750.2	+	9	1368	c.1033G>T	c.(1033-1035)Gcc>Tcc	p.A345S	GDI1_ENST00000465640.1_3'UTR	NM_001493.2	NP_001484.1	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	345					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	16	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAACGTGGCGGCCCAGGGCAA	0.587000													99	48					6.00224e-42	6.76201e-42	1	1	0
TGFB3	7043	broad.mit.edu	37	14	76429803	76429803	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr14:76429803C>T	ENST00000238682.3	-	5	1079	c.782G>A	c.(781-783)cGt>cAt	p.R261H	TGFB3_ENST00000556285.1_Missense_Mutation_p.R261H	NM_003239.2	NP_003230.1	P10600	TGFB3_HUMAN	transforming growth factor, beta 3	261					cell growth|cell-cell junction organization|detection of hypoxia|face morphogenesis|in utero embryonic development|induction of apoptosis|lung alveolus development|mammary gland development|menstrual cycle phase|negative regulation of cell proliferation|negative regulation of DNA replication|negative regulation of macrophage cytokine production|negative regulation of neuron apoptosis|odontogenesis|ossification involved in bone remodeling|palate development|platelet activation|platelet degranulation|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of collagen biosynthetic process|positive regulation of DNA replication|positive regulation of epithelial to mesenchymal transition|positive regulation of filopodium assembly|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|response to progesterone stimulus|salivary gland morphogenesis|transforming growth factor beta receptor signaling pathway	extracellular matrix|platelet alpha granule lumen	growth factor activity|identical protein binding|transforming growth factor beta binding|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11				BRCA - Breast invasive adenocarcinoma(234;0.0169)		CAGATCTCCACGGCCATGGTC	0.577000													10	97					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82816337	82816337	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:82816337G>C	ENST00000265077.3	+	7	2777	c.2212G>C	c.(2212-2214)Gag>Cag	p.E738Q	VCAN_ENST00000512590.2_Missense_Mutation_p.E690Q|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.E738Q|VCAN_ENST00000343200.5_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	738	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCATGTTACAGAGTCTTCTGT	0.383000													7	76					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154147055	154147055	+	Missense_Mutation	SNP	A	A	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:154147055A>G	ENST00000389740.2	-	1	449	c.350T>C	c.(349-351)cTc>cCc	p.L117P		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	117						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GTTGCTAGAGAGGCCCTGGCA	0.512000													11	110					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144995483	144995483	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:144995483C>T	ENST00000322810.4	-	32	9086	c.8917G>A	c.(8917-8919)Gac>Aac	p.D2973N	PLEC_ENST00000345136.3_Missense_Mutation_p.D2836N|PLEC_ENST00000356346.3_Missense_Mutation_p.D2822N|PLEC_ENST00000398774.2_Missense_Mutation_p.D2804N|PLEC_ENST00000354958.2_Missense_Mutation_p.D2814N|PLEC_ENST00000354589.3_Missense_Mutation_p.D2836N|PLEC_ENST00000527096.1_Missense_Mutation_p.D2859N|PLEC_ENST00000357649.2_Missense_Mutation_p.D2840N|PLEC_ENST00000436759.2_Missense_Mutation_p.D2863N	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2973	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle	p.D2973N(1)|p.D2836N(1)|p.D2863N(1)		NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ATCTCCTCGTCGAAGTAGCCG	0.667000													16	189					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157773849	157773849	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:157773849G>A	ENST00000358292.3	-	3	156	c.105C>T	c.(103-105)acC>acT	p.T35T	FCRL1_ENST00000368176.3_Silent_p.T35T|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Silent_p.T35T	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	35	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TACACGTCAGGGTCACTGGGC	0.527000													9	117					0	0	1	0	0
UHMK1	127933	broad.mit.edu	37	1	162467790	162467790	+	Translation_Start_Site	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:162467790G>A	ENST00000489294.1	+	0	158				UHMK1_ENST00000545294.1_Intron|UHMK1_ENST00000538489.1_De_novo_Start_InFrame	NM_175866.4	NP_787062.1	Q8TAS1	UHMK1_HUMAN	U2AF homology motif (UHM) kinase 1						cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding			endometrium(1)|large_intestine(2)|lung(6)|prostate(2)	11	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			AACCCACACCGATGGCGGGAT	0.736000													9	74					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65301155	65301155	+	Missense_Mutation	SNP	T	T	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:65301155T>A	ENST00000342505.4	-	24	3541	c.3293A>T	c.(3292-3294)cAg>cTg	p.Q1098L		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	1098	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GACTGTCATCTGGCCATGGGT	0.398000			Mis		ALL								4	143					0	0	1	0	0
ACR	49	broad.mit.edu	37	22	51183206	51183206	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr22:51183206G>T	ENST00000216139.5	+	5	877	c.837G>T	c.(835-837)tgG>tgT	p.W279C	ACR_ENST00000527761.1_3'UTR	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	279	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		CGGCCACCTGGCCCTATCTGA	0.597000													5	17					0.184627	0.18567	1	1	0
MAVS	57506	broad.mit.edu	37	20	3838456	3838456	+	Splice_Site	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:3838456C>T	ENST00000428216.2	+	3	420	c.292_splice	c.e3+1	p.R98_splice	MAVS_ENST00000416600.2_Intron|MAVS_ENST00000358134.6_Splice_Site_p.Q98_splice	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	98					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						CTACCAGCCTCGTGAGCGTCC	0.622000													16	93					0	0	1	0	0
GATA6	2627	broad.mit.edu	37	18	19780633	19780633	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr18:19780633G>A	ENST00000269216.3	+	7	1912	c.1635G>A	c.(1633-1635)gtG>gtA	p.V545V	GATA6_ENST00000581694.1_Silent_p.V545V|RP11-627G18.1_ENST00000583442.1_RNA	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	545					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			GTGCCCCGGTGATGACTGGTG	0.577000													12	83					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65144758	65144758	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:65144758C>G	ENST00000358691.5	-	20	2714	c.2548G>C	c.(2548-2550)Gag>Cag	p.E850Q	HELZ_ENST00000580168.1_Missense_Mutation_p.E851Q	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGGTAATGCTCATAGAGTCGG	0.473000													45	269					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59404982	59404982	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:59404982C>T	ENST00000301645.3	-	5	1282	c.1145G>A	c.(1144-1146)cGa>cAa	p.R382Q		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	382					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding	p.R382Q(1)		breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GTCATCTTTTCGGATGTTGTA	0.453000									Neonatal Giant Cell Hepatitis				10	116					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70747681	70747681	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr12:70747681C>T	ENST00000551483.1	+	7	4717	c.562C>T	c.(562-564)Cag>Tag	p.Q188*	CNOT2_ENST00000229195.3_Nonsense_Mutation_p.Q537*|CNOT2_ENST00000418359.3_Nonsense_Mutation_p.Q537*			Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	537					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			CAACCCTGCTCAGCAAGCCTT	0.368000													8	65					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790428	4790428	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:4790428G>A	ENST00000380383.1	-	1	740	c.741C>T	c.(739-741)ttC>ttT	p.F247F	MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Silent_p.F240F|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	240						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		CACAGGTGCTGAAGACCTTGT	0.488000													10	84					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40657441	40657441	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr15:40657441C>A	ENST00000267889.3	+	6	900	c.813C>A	c.(811-813)gaC>gaA	p.D271E		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	271					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCCTGGAGGACAGAAGGCAAG	0.607000													10	86					1.76689e-08	1.91773e-08	1	1	0
KANK2	25959	broad.mit.edu	37	19	11304609	11304609	+	Silent	SNP	G	G	A	rs142504157		TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:11304609G>A	ENST00000432929.2	-	4	507	c.147C>T	c.(145-147)taC>taT	p.Y49Y	KANK2_ENST00000589894.1_Silent_p.Y49Y|KANK2_ENST00000589359.1_Silent_p.Y49Y|KANK2_ENST00000586659.1_Silent_p.Y49Y|KANK2_ENST00000355150.5_Silent_p.Y49Y	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	49										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TGTCATCCACGTACTTGAGGA	0.687000													24	99					0	0	1	0	0
TM4SF5	9032	broad.mit.edu	37	17	4686422	4686422	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:4686422G>A	ENST00000270560.3	+	5	624	c.593G>A	c.(592-594)tGa>tAa	p.*198*		NM_003963.2	NP_003954.2	O14894	T4S5_HUMAN	transmembrane 4 L six family member 5	0						integral to plasma membrane				large_intestine(2)|lung(3)|ovary(1)	6						ACACCTCACTGAGGCTCCACT	0.537000													12	85					0	0	1	0	0
ADCY3	109	broad.mit.edu	37	2	25042882	25042882	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:25042882G>A	ENST00000260600.5	-	21	4205	c.3354C>T	c.(3352-3354)ttC>ttT	p.F1118F	ADCY3_ENST00000405392.1_Silent_p.F705F|CENPO_ENST00000380834.2_3'UTR|CENPO_ENST00000473706.1_3'UTR	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	1118					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GCCCCTTCAAGAAGAAGGTCA	0.587000													6	22					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131022986	131022986	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr9:131022986G>C	ENST00000421699.2	-	17	1447	c.1435C>G	c.(1435-1437)Ctg>Gtg	p.L479V		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	479						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						TGTCCTGCCAGACCCTCCAGC	0.677000													9	67					0	0	1	0	0
POLR3E	55718	broad.mit.edu	37	16	22320358	22320358	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr16:22320358C>T	ENST00000299853.5	+	5	445	c.278C>T	c.(277-279)tCc>tTc	p.S93F	POLR3E_ENST00000418581.2_Missense_Mutation_p.S57F|POLR3E_ENST00000564209.1_Missense_Mutation_p.S93F|POLR3E_ENST00000359210.4_Missense_Mutation_p.S93F|POLR3E_ENST00000564256.1_3'UTR	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	93					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity	p.S93F(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		AGCACGTATTCCTCGTGAGTT	0.597000													9	55					0	0	1	0	0
TNNT2	7139	broad.mit.edu	37	1	201333455	201333455	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:201333455G>A	ENST00000509001.1	-	10	716	c.430C>T	c.(430-432)Cgg>Tgg	p.R144W	TNNT2_ENST00000367315.2_Missense_Mutation_p.R144W|TNNT2_ENST00000421663.2_Missense_Mutation_p.R146W|TNNT2_ENST00000458432.2_Missense_Mutation_p.R156W|TNNT2_ENST00000360372.4_Missense_Mutation_p.R139W|TNNT2_ENST00000236918.7_Missense_Mutation_p.R149W|TNNT2_ENST00000367320.2_Missense_Mutation_p.R114W|TNNT2_ENST00000367318.5_Missense_Mutation_p.R144W|TNNT2_ENST00000367317.4_Missense_Mutation_p.R144W|TNNT2_ENST00000367322.1_Missense_Mutation_p.R144W	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	154					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						TCCTTCTCCCGCTCATTCCGG	0.667000													5	29					0	0	1	0	0
CLDN16	10686	broad.mit.edu	37	3	190106095	190106095	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:190106095C>T	ENST00000264734.2	+	1	435	c.187C>T	c.(187-189)Cat>Tat	p.H63Y	CLDN16_ENST00000468220.1_Intron|CLDN16_ENST00000456423.1_Missense_Mutation_p.H63Y	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	63					calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		CCCATGTTGCCATCCTGATGG	0.498000													31	138					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678215	87678215	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr16:87678215G>A	ENST00000284262.2	+	2	976	c.734G>A	c.(733-735)cGc>cAc	p.R245H		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	245					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		AGCTCCTTTCGCAGCGAGGCG	0.662000													11	95					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52000215	52000215	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:52000215C>T	ENST00000291707.3	-	7	1573	c.1518G>A	c.(1516-1518)agG>agA	p.R506R	SIGLEC12_ENST00000598614.1_Silent_p.R388R	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	506					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCGATTTCTTCCTGCAGGACC	0.572000													16	103					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73136479	73136479	+	Missense_Mutation	SNP	G	G	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:73136479G>T	ENST00000545377.1	+	11	1497	c.1321G>T	c.(1321-1323)Gcc>Tcc	p.A441S	ARHGEF28_ENST00000513042.2_Missense_Mutation_p.A441S|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.A441S|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.A128S|ARHGEF28_ENST00000513841.1_3'UTR|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.A441S|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.A441S|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.A441S	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		ACACACTGAAGCCCAGCAGTC	0.463000													11	36					6.40141e-05	6.70265e-05	1	1	0
FLG	2312	broad.mit.edu	37	1	152280354	152280354	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:152280354C>T	ENST00000368799.1	-	3	7043	c.7008G>A	c.(7006-7008)caG>caA	p.Q2336Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2336	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTGCTGACTGCTGGTGGT	0.562000									Ichthyosis				19	631					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153036810	153036810	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chrX:153036810G>A	ENST00000538966.1	+	14	2639	c.2368G>A	c.(2368-2370)Gtc>Atc	p.V790I	PLXNB3_ENST00000361971.5_Missense_Mutation_p.V767I|PLXNB3_ENST00000538282.1_Missense_Mutation_p.V377I|PLXNB3_ENST00000538776.1_Missense_Mutation_p.V420I|PLXNB3_ENST00000538543.1_Intron	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	767					axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCCATCTACGTCACCCAGGG	0.637000													36	22					0	0	1	0	0
SLC38A1	81539	broad.mit.edu	37	12	46591532	46591532	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr12:46591532C>T	ENST00000398637.5	-	16	2027	c.1333G>A	c.(1333-1335)Gat>Aat	p.D445N	SLC38A1_ENST00000439706.1_Missense_Mutation_p.D445N|SLC38A1_ENST00000549049.1_Missense_Mutation_p.D445N|SLC38A1_ENST00000546893.1_Missense_Mutation_p.D445N|SLC38A1_ENST00000552197.1_Missense_Mutation_p.D445N	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	445					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TTATCTCCATCCTGGTCTGTG	0.318000													7	84					0	0	1	0	0
BRD9	65980	broad.mit.edu	37	5	878554	878554	+	Nonsense_Mutation	SNP	G	G	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:878554G>T	ENST00000323510.4	-	8	898	c.899C>A	c.(898-900)tCa>tAa	p.S300*	BRD9_ENST00000467963.1_Nonsense_Mutation_p.S396*|BRD9_ENST00000435709.2_3'UTR|BRD9_ENST00000483173.1_Nonsense_Mutation_p.S343*|BRD9_ENST00000494422.1_5'UTR|BRD9_ENST00000388890.4_Nonsense_Mutation_p.S280*			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	396							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GCCAAATACTGAATTATTCTG	0.557000													4	131					0.000602214	0.000619619	1	1	0
MOSPD2	158747	broad.mit.edu	37	X	14927078	14927078	+	Missense_Mutation	SNP	A	A	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chrX:14927078A>G	ENST00000380492.3	+	8	762	c.674A>G	c.(673-675)gAa>gGa	p.E225G	MOSPD2_ENST00000495110.1_3'UTR|MOSPD2_ENST00000482354.1_Missense_Mutation_p.E225G	NM_001177475.1|NM_152581.3	NP_001170946.1|NP_689794.1	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	225	CRAL-TRIO.					integral to membrane	structural molecule activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	Hepatocellular(33;0.183)					GTCAGTGTAGAATACCTGCCT	0.408000													47	48					0	0	1	0	0
RBM23	55147	broad.mit.edu	37	14	23374207	23374207	+	Silent	SNP	T	T	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr14:23374207T>A	ENST00000359890.3	-	9	936	c.741A>T	c.(739-741)cgA>cgT	p.R247R	RBM23_ENST00000555209.1_5'UTR|RBM23_ENST00000346528.5_Silent_p.R213R|RBM23_ENST00000542016.2_Silent_p.R77R|RBM23_ENST00000399922.2_Silent_p.R231R	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	247					mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		TGGCTGCCAGTCGGTTTTTCT	0.522000													27	164					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30750224	30750224	+	Missense_Mutation	SNP	T	T	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr16:30750224T>C	ENST00000262518.4	+	34	9248	c.8863T>C	c.(8863-8865)Tcc>Ccc	p.S2955P	SRCAP_ENST00000395059.2_Missense_Mutation_p.S2893P|SRCAP_ENST00000344771.4_Missense_Mutation_p.S2797P	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2955	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TGGGACCATTTCCTCTGCAGG	0.587000													7	100					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29998048	29998048	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr16:29998048G>A	ENST00000308893.4	+	16	3498	c.2455G>A	c.(2455-2457)Gaa>Aaa	p.E819K	TAOK2_ENST00000416441.2_Missense_Mutation_p.E646K|TAOK2_ENST00000543033.1_Intron|TAOK2_ENST00000279394.3_Intron	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	819	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GATTCTGGGGGAAGAATCAGG	0.552000													12	113					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62939740	62939740	+	Missense_Mutation	SNP	T	T	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:62939740T>C	ENST00000251157.5	-	47	6125	c.6092A>G	c.(6091-6093)cAg>cGg	p.Q2031R	DOCK7_ENST00000489185.1_5'UTR|DOCK7_ENST00000340370.5_Missense_Mutation_p.Q2011R	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	2042	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						CAGAAAAACCTGGGCAACTTC	0.343000													10	66					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004595	41004595	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:41004595G>A	ENST00000399564.4	-	37	4497	c.4047C>T	c.(4045-4047)atC>atT	p.I1349I	MROH2B_ENST00000506092.2_Silent_p.I904I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GGCCTCTGATGATAGATTCTA	0.423000													8	85					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111398996	111398996	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:111398996G>A	ENST00000535254.1	-	21	2678	c.2611C>T	c.(2611-2613)Caa>Taa	p.Q871*	BUB1_ENST00000302759.6_Nonsense_Mutation_p.Q891*|BUB1_ENST00000409311.1_Intron|BUB1_ENST00000478175.1_5'UTR	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	891	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ACAAGACCTTGAGGCATCACT	0.353000													10	127					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55522555	55522555	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr16:55522555G>A	ENST00000219070.4	+	6	1442	c.933G>A	c.(931-933)acG>acA	p.T311T	MMP2_ENST00000570308.1_Silent_p.T235T|MMP2_ENST00000543485.1_Silent_p.T235T|MMP2_ENST00000437642.2_Silent_p.T261T	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	311	Collagen-binding.|Fibronectin type-II 2.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding	p.T311T(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	AGGGCCGCACGGATGGCTACC	0.627000													9	24					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41005005	41005005	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:41005005G>C	ENST00000399564.4	-	36	4332	c.3882C>G	c.(3880-3882)atC>atG	p.I1294M	MROH2B_ENST00000506092.2_Missense_Mutation_p.I849M	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GCTTCCAAAGGATTGGTTCCT	0.512000													4	51					0	0	1	0	0
ZNF646	9726	broad.mit.edu	37	16	31089734	31089734	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr16:31089734C>T	ENST00000394979.2	+	1	2512	c.2089C>T	c.(2089-2091)Cgg>Tgg	p.R697W	ZNF646_ENST00000300850.5_Missense_Mutation_p.R697W			O15015	ZN646_HUMAN	zinc finger protein 646	697					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						GAGCTGGACCCGGGAGCTAGA	0.642000													10	56					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66416435	66416435	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:66416435G>A	ENST00000448504.2	+	12	2205	c.1409G>A	c.(1408-1410)aGa>aAa	p.R470K	ARSG_ENST00000452479.2_Missense_Mutation_p.R306K|ARSG_ENST00000582154.1_3'UTR|RP11-120M18.2_ENST00000592030.1_RNA	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	470					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCCCTAGAAAGAGGTGGTGCG	0.562000													9	87					0	0	1	0	0
RHBDD3	25807	broad.mit.edu	37	22	29656760	29656760	+	Missense_Mutation	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr22:29656760C>A	ENST00000216085.7	-	5	1050	c.626G>T	c.(625-627)tGg>tTg	p.W209L		NM_012265.1	NP_036397.1	Q9Y3P4	RHBD3_HUMAN	rhomboid domain containing 3	209						integral to membrane	serine-type endopeptidase activity			lung(1)|ovary(1)	2						CCTCAGGGGCCAGCACCCCGC	0.687000													3	6					1	1	1	1	0
IDO1	3620	broad.mit.edu	37	8	39776344	39776344	+	Missense_Mutation	SNP	G	G	A	rs12545877		TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:39776344G>A	ENST00000518237.1	+	4	953	c.314G>A	c.(313-315)aGa>aAa	p.R105K	RP11-44K6.4_ENST00000522970.1_RNA|RP11-44K6.3_ENST00000517623.1_RNA|IDO1_ENST00000522495.1_Missense_Mutation_p.R105K	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	105					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	GTCTTGCCAAGAAATATTGCT	0.358000													9	55					0	0	1	0	0
TLR1	7096	broad.mit.edu	37	4	38800318	38800318	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr4:38800318C>G	ENST00000308979.2	-	4	408	c.135G>C	c.(133-135)caG>caC	p.Q45H	TLR1_ENST00000502213.2_Missense_Mutation_p.Q45H	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	45					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						TTGTTGTTTTCTGGGATAGGT	0.313000													24	270					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9101001	9101001	+	Missense_Mutation	SNP	A	A	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:9101001A>C	ENST00000457346.2	-	3	386	c.312T>G	c.(310-312)aaT>aaG	p.N104K	SCUBE2_ENST00000520467.1_Missense_Mutation_p.N104K|SCUBE2_ENST00000450649.2_Missense_Mutation_p.N104K|SCUBE2_ENST00000309263.3_Missense_Mutation_p.N104K			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	104	EGF-like 2; calcium-binding (Potential).					extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TGCCTGGAATATTCAAACAGT	0.408000													14	123					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15302802	15302802	+	Silent	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:15302802G>A	ENST00000263388.2	-	4	723	c.648C>T	c.(646-648)ggC>ggT	p.G216G		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	216	EGF-like 5.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AAGTGAGGTCGCCACTCTGCC	0.657000													7	46					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	65983656	65983656	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:65983656G>C	ENST00000320580.4	+	5	760	c.727G>C	c.(727-729)Gtg>Ctg	p.V243L		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	243					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						GGATGTCTCTGTGCCTGTGGC	0.522000													10	83					0	0	1	0	0
RAC2	5880	broad.mit.edu	37	22	37637645	37637645	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr22:37637645C>T	ENST00000249071.6	-	2	210	c.89G>A	c.(88-90)gGa>gAa	p.G30E	RAC2_ENST00000405484.1_Missense_Mutation_p.G23E|RAC2_ENST00000401529.3_Missense_Mutation_p.G30E|RAC2_ENST00000406508.1_5'UTR	NM_002872.3	NP_002863.1	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	30					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	12						GATGTACTCTCCGGGAAAGGC	0.617000													14	127					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82815353	82815353	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr5:82815353G>C	ENST00000265077.3	+	7	1793	c.1228G>C	c.(1228-1230)Gtc>Ctc	p.V410L	VCAN_ENST00000512590.2_Missense_Mutation_p.V362L|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.V410L|VCAN_ENST00000343200.5_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	410	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAAAGCCACAGTCCAACCTCA	0.453000													19	134					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25505442	25505442	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:25505442G>A	ENST00000264709.3	-	4	653	c.316C>T	c.(316-318)Cct>Tct	p.P106S	DNMT3A_ENST00000321117.5_Missense_Mutation_p.P106S|DNMT3A_ENST00000406659.3_Missense_Mutation_p.P106S	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	106					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCCAGCAGGGCTCCCCTCC	0.652000			"""Mis, F, N, S"""		AML								4	48					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128481927	128481927	+	Silent	SNP	T	T	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:128481927T>A	ENST00000322313.4	-	11	1334	c.1176A>T	c.(1174-1176)tcA>tcT	p.S392S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	392					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CATTTGAGCCTGAGCAGAGAA	0.428000													10	63					0	0	1	0	0
FXYD7	53822	broad.mit.edu	37	19	35639599	35639599	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:35639599C>T	ENST00000270310.2	+	2	118	c.34C>T	c.(34-36)Cct>Tct	p.P12S	FXYD7_ENST00000588265.1_Missense_Mutation_p.P12S|CTD-2527I21.4_ENST00000592174.1_RNA|FXYD7_ENST00000586063.1_Missense_Mutation_p.P12S	NM_022006.1	NP_071289.1	P58549	FXYD7_HUMAN	FXYD domain containing ion transport regulator 7	12						integral to membrane	ion channel activity			NS(1)|endometrium(1)|lung(1)	3	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;2.32e-21)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;2.43e-18)|LUSC - Lung squamous cell carcinoma(66;0.0849)			tccctcAGCTCCTGAGGAACC	0.448000													15	95					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940045	22940045	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:22940045C>G	ENST00000397104.3	-	6	2285	c.2286G>C	c.(2284-2286)agG>agC	p.R762S						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTTATGTTTCCTAAGGGTTG	0.358000													9	85					0	0	1	0	0
PHF20L1	51105	broad.mit.edu	37	8	133858108	133858108	+	Missense_Mutation	SNP	A	A	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:133858108A>G	ENST00000395386.2	+	21	3293	c.2994A>G	c.(2992-2994)atA>atG	p.I998M	PHF20L1_ENST00000395390.2_Missense_Mutation_p.I973M|PHF20L1_ENST00000220847.7_Missense_Mutation_p.I385M	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	998							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AACGCCACATAAAACAGCTCC	0.433000													20	105					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7807798	7807798	+	Missense_Mutation	SNP	G	G	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:7807798G>C	ENST00000380358.4	+	25	4111	c.4110G>C	c.(4108-4110)gaG>gaC	p.E1370D	CHD3_ENST00000330494.7_Missense_Mutation_p.E1311D|CHD3_ENST00000358181.4_Missense_Mutation_p.E1311D	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1311					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				AGCAGGAGGAGAATGTGGACC	0.517000													8	96					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46793105	46793105	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr6:46793105C>T	ENST00000230588.4	+	8	662	c.653C>T	c.(652-654)tCa>tTa	p.S218L		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	218	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CAGCCTTTCTCATTTAACAAG	0.428000													12	93					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81762966	81762966	+	Missense_Mutation	SNP	T	T	C			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr12:81762966T>C	ENST00000550584.2	-	11	1569	c.1274A>G	c.(1273-1275)gAg>gGg	p.E425G	PPFIA2_ENST00000550359.2_Missense_Mutation_p.E272G|PPFIA2_ENST00000443686.3_Missense_Mutation_p.E326G|PPFIA2_ENST00000541017.1_5'UTR|PPFIA2_ENST00000549325.1_Missense_Mutation_p.E407G|PPFIA2_ENST00000333447.7_Missense_Mutation_p.E407G|PPFIA2_ENST00000407050.4_Missense_Mutation_p.E351G|PPFIA2_ENST00000548586.1_Missense_Mutation_p.E425G|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000541570.2_5'UTR|PPFIA2_ENST00000549396.1_Missense_Mutation_p.E425G|PPFIA2_ENST00000552948.1_Missense_Mutation_p.E425G	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	351										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TCCATGTCTCTCTTCAGCCTG	0.308000													3	22					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54868206	54868206	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:54868206C>T	ENST00000391743.3	-	5	703	c.423G>A	c.(421-423)ctG>ctA	p.L141L	LAIR1_ENST00000391742.2_Silent_p.L159L|LAIR1_ENST00000348231.4_Silent_p.L142L|LAIR1_ENST00000474878.1_Silent_p.L141L|LAIR1_ENST00000434277.2_Silent_p.L158L|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000313038.6_Silent_p.L152L			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	159						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		GCTCAGCTTTCAGGCCTTGGG	0.493000													12	116					0	0	1	0	0
DEFB118	117285	broad.mit.edu	37	20	29960947	29960947	+	Missense_Mutation	SNP	C	C	G			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:29960947C>G	ENST00000253381.2	+	2	379	c.346C>G	c.(346-348)Ctt>Gtt	p.L116V		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	116					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region		p.L116I(1)		breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TGAGACCTCTCTTCCAAATGT	0.433000													8	67					0	0	1	0	0
C3orf72	401089	broad.mit.edu	37	3	138669233	138669233	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:138669233C>T	ENST00000383165.3	+	3	478	c.347C>T	c.(346-348)tCc>tTc	p.S116F		NM_001040061.2	NP_001035150.1	Q6ZUU3	CC072_HUMAN	chromosome 3 open reading frame 72	116										large_intestine(1)|lung(3)	4						CTCAGCTCGTCCCGCGCCGCC	0.697000													5	59					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356272	42356272	+	Silent	SNP	C	C	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr14:42356272C>A	ENST00000554171.1	+	5	2876	c.444C>A	c.(442-444)gcC>gcA	p.A148A	LRFN5_ENST00000554120.1_Silent_p.A148A|LRFN5_ENST00000298119.4_Silent_p.A148A			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	148						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ATGTCTTCGCCCTTGAGGAGC	0.393000										HNSCC(30;0.082)			13	115					1.5842e-08	1.72999e-08	1	1	0
SSX2IP	117178	broad.mit.edu	37	1	85121552	85121552	+	Missense_Mutation	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:85121552C>T	ENST00000437941.2	-	10	1623	c.1271G>A	c.(1270-1272)cGa>cAa	p.R424Q	SSX2IP_ENST00000603677.1_Intron|SSX2IP_ENST00000370612.4_Missense_Mutation_p.R451Q|SSX2IP_ENST00000342203.3_Missense_Mutation_p.R451Q|SSX2IP_ENST00000605755.1_Missense_Mutation_p.R424Q	NM_001166295.1|NM_001166417.1	NP_001159767.1|NP_001159889.1	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting protein	451					cell adhesion	nucleus|protein complex				endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|urinary_tract(1)	19				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TGTAAAGCTTCGTCTCTCCCT	0.413000													10	104					0	0	1	0	0
OR4F17	81099	broad.mit.edu	37	19	110700	110700	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:110700C>T	ENST00000585993.1	+	2	161	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	OR4F17_ENST00000318050.3_Silent_p.L8L			Q8NGA8	O4F17_HUMAN	olfactory receptor, family 4, subfamily F, member 17	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(2)	2		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATTCATTTTTCTGGGTCTCTC	0.393000													41	825					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240070945	240070945	+	Missense_Mutation	SNP	T	T	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:240070945T>A	ENST00000255380.4	+	5	973	c.194T>A	c.(193-195)gTc>gAc	p.V65D		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	65			V -> I (in dbSNP:rs2067481).		cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GGTCATACCGTCTGGCAAGTG	0.517000													9	98					0	0	1	0	0
GGH	8836	broad.mit.edu	37	8	63942735	63942735	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr8:63942735G>A	ENST00000260118.6	-	3	668	c.266C>T	c.(265-267)tCt>tTt	p.S89F	GGH_ENST00000518113.1_5'UTR	NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	89	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	CCCATTAATAGATTTGAAAAG	0.294000													12	127					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17434461	17434461	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:17434461C>T	ENST00000262545.2	+	9	1275	c.960C>T	c.(958-960)gaC>gaT	p.D320D	PCSK2_ENST00000536609.1_Silent_p.D285D|PCSK2_ENST00000377899.1_Silent_p.D301D	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	320	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity	p.D320D(1)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCAACTGCGACGGCTACGCCT	0.647000													13	89					0	0	1	0	0
SPATS2L	26010	broad.mit.edu	37	2	201304030	201304030	+	Missense_Mutation	SNP	G	G	A			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr2:201304030G>A	ENST00000409988.3	+	7	1154	c.631G>A	c.(631-633)Gat>Aat	p.D211N	SPATS2L_ENST00000409151.1_Missense_Mutation_p.D219N|SPATS2L_ENST00000409385.1_Missense_Mutation_p.D151N|SPATS2L_ENST00000451764.2_Missense_Mutation_p.D211N|SPATS2L_ENST00000409755.3_Missense_Mutation_p.D241N|SPATS2L_ENST00000409140.3_Missense_Mutation_p.D211N|SPATS2L_ENST00000409718.1_Missense_Mutation_p.D211N|SPATS2L_ENST00000358677.4_Missense_Mutation_p.D211N|SPATS2L_ENST00000360760.5_Intron	NM_001100422.1	NP_001093892.1	Q9NUQ6	SPS2L_HUMAN	spermatogenesis associated, serine-rich 2-like	211						cytoplasm|nucleolus				endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	10						AATAAAGCCAGATGAGTTGGC	0.413000													9	46					0	0	1	0	0
EHHADH	1962	broad.mit.edu	37	3	184922274	184922274	+	Silent	SNP	C	C	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:184922274C>T	ENST00000231887.3	-	6	915	c.840G>A	c.(838-840)aaG>aaA	p.K280K	EHHADH_ENST00000456310.1_Silent_p.K184K	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	280	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	GAGTTGACCACTTATTTGCTT	0.493000													12	180					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25144712	25144712	+	RNA	SNP	A	A	C	rs71218558	by1000genomes	TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr13:25144712A>C	ENST00000453498.1	+	0	253																											TGTGTTTAACACAGCCCCTGC	0.393000													3	47					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1116223	1116223	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:1116223delG	ENST00000379290.1	+	8	911	c.738delG	c.(736-738)ccfs	p.P246fs	TTLL10_ENST00000379289.1_Frame_Shift_Del_p.P246fs|TTLL10_ENST00000379288.3_Frame_Shift_Del_p.P173fs			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	246	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCAAGGTGCCGGGGGGGGTCC	0.721													3	6	---	---	---	---					
PKP1	5317	broad.mit.edu	37	1	201287782	201287783	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr1:201287782_201287783insGG	ENST00000263946.3	+	6	1342_1343	c.1091_1092insGG	c.(1090-1092)agafs	p.R364fs	PKP1_ENST00000367324.3_Frame_Shift_Ins_p.R364fs|PKP1_ENST00000352845.3_Frame_Shift_Ins_p.R364fs|PKP1_ENST00000475988.1_3'UTR	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	364					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						GACGAGCTGAAGGAGGAACTCA	0.589													13	54	---	---	---	---					
VEPH1	79674	broad.mit.edu	37	3	157081226	157081227	+	Frame_Shift_Ins	INS	-	-	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr3:157081226_157081227insT	ENST00000362010.2	-	9	1968_1969	c.1661_1662insA	c.(1660-1662)actfs	p.T554fs	VEPH1_ENST00000392833.2_Frame_Shift_Ins_p.T554fs|VEPH1_ENST00000392832.2_Frame_Shift_Ins_p.T554fs|VEPH1_ENST00000543418.1_Frame_Shift_Ins_p.T554fs|RP11-550I24.2_ENST00000487238.1_RNA	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	554						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CTTTGCTGAGGTTTTTTTTTAA	0.396													7	353	---	---	---	---					
ADAM29	11086	broad.mit.edu	37	4	175897464	175897464	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr4:175897464delG	ENST00000359240.3	+	5	1458	c.788delG	c.(787-789)agfs	p.R263fs	ADAM29_ENST00000404450.4_Frame_Shift_Del_p.R263fs|ADAM29_ENST00000514159.1_Frame_Shift_Del_p.R263fs|ADAM29_ENST00000445694.1_Frame_Shift_Del_p.R263fs	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	263	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GATGATGTAAGGAAATCTGTG	0.403													20	124	---	---	---	---					
CELP	1057	broad.mit.edu	37	9	135962465	135962465	+	RNA	DEL	T	T	-	rs63239560		TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr9:135962465delT	ENST00000411440.2	+	0	972					NR_001275.2																						AGGATGCCCCTGTGCCCCTCA	0.677													2	4	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6662745	6662746	+	In_Frame_Ins	INS	-	-	CAG	rs56194704		TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:6662745_6662746insCAG	ENST00000299441.3	-	2	510_511	c.99_100insCTG	c.(97-102)ctgggc>ctCTGgggc	p.33_34LG>LWG		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	33					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L33_G34insL(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCCCAGCCCCcagcagcagca	0.639													5	7	---	---	---	---					
OR8J3	81168	broad.mit.edu	37	11	55904894	55904894	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr11:55904894delG	ENST00000301529.1	-	1	300	c.301delC	c.(301-303)tgfs	p.L101fs		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AACCCTCCCAGTTGGGTGGCA	0.428													33	203	---	---	---	---					
LINC00933	100506874	broad.mit.edu	37	15	85115423	85115423	+	RNA	DEL	T	T	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr15:85115423delT	ENST00000557887.1	+	0	1					NR_038273.1|NR_038274.1																						CATAATGCTCttttttttttt	0.393													7	15	---	---	---	---					
UPF3AP2	147150	broad.mit.edu	37	17	20279654	20279655	+	RNA	INS	-	-	T			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr17:20279654_20279655insT	ENST00000578315.1	-	0	51_52																											atctgtctctcttttttttttt	0.381													4	2	---	---	---	---					
POLD1	5424	broad.mit.edu	37	19	50918125	50918127	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:50918125_50918127delCTC	ENST00000440232.2	+	20	2495_2497	c.2442_2444delCTC	c.(2440-2445)ttc>tt	p.FS814del	POLD1_ENST00000599857.1_In_Frame_Del_p.FS814del|POLD1_ENST00000595904.1_In_Frame_Del_p.FS840del	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	814					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GCCTGCTCTTCTCCTCCCGGCCC	0.660								DNA polymerases (catalytic subunits)			OREG0025635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	106	---	---	---	---					
ZNF813	126017	broad.mit.edu	37	19	53995003	53995003	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr19:53995003delG	ENST00000396403.4	+	4	1645	c.1517delG	c.(1516-1518)cgfs	p.R506fs	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		GGTTTTAATCGGAAAACACAC	0.403													16	105	---	---	---	---					
PLCB4	5332	broad.mit.edu	37	20	9424842	9424842	+	Frame_Shift_Del	DEL	A	A	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr20:9424842delA	ENST00000378501.2	+	28	2811	c.2796delA	c.(2794-2796)ttfs	p.L932fs	PLCB4_ENST00000414679.2_Frame_Shift_Del_p.L944fs|PLCB4_ENST00000378493.1_Frame_Shift_Del_p.L932fs|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000334005.3_Frame_Shift_Del_p.L932fs|PLCB4_ENST00000378473.3_Frame_Shift_Del_p.L944fs|PLCB4_ENST00000278655.4_Frame_Shift_Del_p.L932fs	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	932					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TGAAGCATTTAAAGAAACAGC	0.308													35	215	---	---	---	---					
PIGP	51227	broad.mit.edu	37	21	38444895	38444895	+	Translation_Start_Site	DEL	T	T	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr21:38444895delT	ENST00000464265.1	-	0	216				PIGP_ENST00000399102.1_Intron|PIGP_ENST00000360525.3_Intron|PIGP_ENST00000399103.1_Intron|PIGP_ENST00000399098.1_Intron	NM_153681.2	NP_710148.1	P57054	PIGP_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class P						C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			kidney(1)|urinary_tract(1)	2		Myeloproliferative disorder(46;0.0412)				CATTGATCCATTCTCGCCTCC	0.637													44	156	---	---	---	---					
LA16c-23H5.4	0	broad.mit.edu	37	22	16419352	16419352	+	RNA	DEL	T	T	-			TCGA-TN-A7HJ-01A-12D-A34J-08	TCGA-TN-A7HJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0f1f591-4348-43e6-aac0-ef6109c7e974	d84baa10-8821-4e2e-89ac-b77dd5c473b2	g.chr22:16419352delT	ENST00000444162.1	+	0	279																											GAATCGACGATTTTTTTTTTG	0.398													2	4	---	---	---	---					
