Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GRM7	2917	broad.mit.edu	37	3	7620568	7620568	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:7620568C>T	ENST00000486284.1	+	8	2249	c.1975C>T	c.(1975-1977)Cga>Tga	p.R659*	GRM7_ENST00000357716.4_Nonsense_Mutation_p.R659*|GRM7_ENST00000402647.2_Nonsense_Mutation_p.R659*|GRM7_ENST00000389336.4_Nonsense_Mutation_p.R659*|GRM7_ENST00000403881.1_Nonsense_Mutation_p.R659*|GRM7_ENST00000458641.2_3'UTR	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	659					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TTCTTTCCGGCGAGTTTTCTT	0.453000													27	92					0	0	1	0	0
PLEKHN1	84069	broad.mit.edu	37	1	906558	906558	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:906558G>A	ENST00000379409.2	+	6	864	c.834G>A	c.(832-834)tcG>tcA	p.S278S	PLEKHN1_ENST00000379407.2_Silent_p.S238S|PLEKHN1_ENST00000379410.3_Silent_p.S226S			Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N member 1	278	PH 2.									central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|skin(1)|urinary_tract(1)	9	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TCTGTGCCTCGAGGGTCAAGC	0.692000													8	4					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131487215	131487215	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:131487215C>A	ENST00000309926.4	+	1	573	c.491C>A	c.(490-492)gCt>gAt	p.A164D		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	164						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					TCCCATGGGGCTGCCTGGAAG	0.602000													6	23					8.12818e-05	8.44282e-05	1	1	0
CHRDL1	91851	broad.mit.edu	37	X	109937530	109937530	+	Silent	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrX:109937530A>G	ENST00000218054.4	-	8	832	c.636T>C	c.(634-636)gaT>gaC	p.D212D	CHRDL1_ENST00000372045.1_Silent_p.D206D|CHRDL1_ENST00000444321.2_Silent_p.D212D|CHRDL1_ENST00000482160.1_Silent_p.D133D|CHRDL1_ENST00000434224.1_Silent_p.D133D|CHRDL1_ENST00000372042.1_Silent_p.D213D|CHRDL1_ENST00000394797.4_Silent_p.D212D	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	206					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TTGGTGGAGGATCATAGTGAG	0.473000													24	46					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131848963	131848963	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr7:131848963C>T	ENST00000359827.3	-	24	5400	c.4438G>A	c.(4438-4440)Gag>Aag	p.E1480K	PLXNA4_ENST00000321063.4_Missense_Mutation_p.E1480K			Q9HCM2	PLXA4_HUMAN	plexin A4	1480						integral to membrane|intracellular|plasma membrane		p.E1480K(2)		NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TAGCGGGCCTCGCCCGTGATG	0.592000													4	28					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176934360	176934360	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:176934360T>C	ENST00000367654.2	-	9	1574	c.1561A>G	c.(1561-1563)Aca>Gca	p.T521A	ASTN1_ENST00000424564.2_Missense_Mutation_p.T513A|ASTN1_ENST00000367657.3_Missense_Mutation_p.T513A|ASTN1_ENST00000361833.2_Missense_Mutation_p.T513A|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	521					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TGAAATATTGTGTAAGGCCAT	0.418000													21	73					0	0	1	0	0
RRAD	6236	broad.mit.edu	37	16	66957606	66957606	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr16:66957606C>A	ENST00000299759.6	-	4	712	c.462G>T	c.(460-462)ttG>ttT	p.L154F	RRAD_ENST00000420652.1_Missense_Mutation_p.L154F			P55042	RAD_HUMAN	Ras-related associated with diabetes	154					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		AGTGGCCGGGCAACCAGCGGC	0.612000													18	81					2.94398e-08	3.15987e-08	1	1	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													4	47					0	0	1	0	0
TMEM50B	757	broad.mit.edu	37	21	34841096	34841096	+	Silent	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr21:34841096A>G	ENST00000542230.2	-	2	311	c.97T>C	c.(97-99)Ttg>Ctg	p.L33L		NM_006134.6	NP_006125.2	P56557	TM50B_HUMAN	transmembrane protein 50B	33						endoplasmic reticulum|integral to membrane|plasma membrane				breast(1)|kidney(1)|ovary(1)|skin(1)	4						TCACTTACCAATATACCTGCG	0.423000													28	56					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6065882	6065882	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr20:6065882T>C	ENST00000217289.4	-	12	2212	c.1424A>G	c.(1423-1425)aAa>aGa	p.K475R	FERMT1_ENST00000478194.1_5'UTR|FERMT1_ENST00000536936.1_Missense_Mutation_p.K218R	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	475	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TGCCATGGTTTTGCCCTTCGA	0.512000													19	102					0	0	1	0	0
XXYLT1	152002	broad.mit.edu	37	3	194947506	194947506	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:194947506C>G	ENST00000310380.6	-	2	692	c.584G>C	c.(583-585)gGc>gCc	p.G195A	XXYLT1_ENST00000429994.1_Missense_Mutation_p.G49A	NM_152531.4	NP_689744.3	Q8NBI6	CC021_HUMAN	xyloside xylosyltransferase 1	195						integral to membrane	transferase activity, transferring glycosyl groups										GGTTCCCAAGCCAGCACTGAA	0.532000													12	77					0	0	1	0	0
WNT3	7473	broad.mit.edu	37	17	44845707	44845707	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:44845707G>A	ENST00000225512.5	-	4	1209	c.1047C>T	c.(1045-1047)taC>taT	p.Y349Y		NM_030753.4	NP_110380.1	P56703	WNT3_HUMAN	wingless-type MMTV integration site family, member 3	349					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(9;0.0257)			TGTGCACGTCGTAGATGCGAA	0.617000													14	43					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8122379	8122379	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:8122379G>A	ENST00000305253.4	+	12	1628	c.1387G>A	c.(1387-1389)Gag>Aag	p.E463K	TUB_ENST00000299506.2_Missense_Mutation_p.E408K|TUB_ENST00000534099.1_Missense_Mutation_p.E414K	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	408					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		CCAGGAGCATGAGACACTGCT	0.547000													15	44					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51897826	51897826	+	Splice_Site	SNP	A	A	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:51897826A>C	ENST00000371117.3	-	29	3640		c.e29+1		PKHD1_ENST00000340994.4_Splice_Site	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CACATATTTTACCTGCTATAT	0.353000													40	137					0	0	1	0	0
PANK2	80025	broad.mit.edu	37	20	3897632	3897632	+	Nonsense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr20:3897632A>T	ENST00000497424.1	+	5	909	c.598A>T	c.(598-600)Aga>Tga	p.R200*	PANK2_ENST00000316562.4_Nonsense_Mutation_p.R491*|PANK2_ENST00000336066.3_3'UTR	NM_024960.4|NM_153640.2	NP_079236.3|NP_705904.1	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2	491					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GGACCTGGCCAGAGCGACTTT	0.448000													42	80					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1264581	1264581	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:1264581C>T	ENST00000447027.1	+	31	6538	c.6480C>T	c.(6478-6480)ccC>ccT	p.P2160P	MUC5B_ENST00000529681.1_Silent_p.P2157P|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2157	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ggacaactcccatccccccag	0.647000													3	11					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10668543	10668543	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:10668543G>A	ENST00000312962.6	-	15	1425	c.1406C>T	c.(1405-1407)cCg>cTg	p.P469L	KRI1_ENST00000361821.5_Missense_Mutation_p.P465L	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	469										NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TTTCTTCCTCGGCTGGCTGGG	0.667000													4	14					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26812851	26812851	+	Missense_Mutation	SNP	G	G	A	rs144496462		TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:26812851G>A	ENST00000541819.2	-	8	982	c.880C>T	c.(880-882)Cgg>Tgg	p.R294W	GABRB3_ENST00000299267.4_Missense_Mutation_p.R238W|GABRB3_ENST00000545868.1_Missense_Mutation_p.R153W|GABRB3_ENST00000400188.3_Missense_Mutation_p.R167W|GABRB3_ENST00000311550.5_Missense_Mutation_p.R238W			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	238					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CTCTTCAACCGAAAGCTCAGT	0.428000													11	60					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815564	23815564	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr4:23815564G>A	ENST00000264867.2	-	8	1661	c.1542C>T	c.(1540-1542)agC>agT	p.S514S	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	514					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TTTCATCTTCGCTGTCATCAA	0.413000													28	112					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10404677	10404677	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:10404677G>T	ENST00000226207.5	-	27	3582	c.3488C>A	c.(3487-3489)gCc>gAc	p.A1163D	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1163				A -> T (in Ref. 4; CAA27380).		muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CTCAATCTGGGCTGAGGTGGC	0.637000													39	195					8.01111e-26	9.34629e-26	1	1	0
PSMD14	10213	broad.mit.edu	37	2	162242001	162242001	+	Silent	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:162242001C>A	ENST00000409682.3	+	8	1193	c.489C>A	c.(487-489)atC>atA	p.I163I		NM_005805.5	NP_005796.1	O00487	PSDE_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	163					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)	12						TCAGATTGATCAATGCTAATA	0.363000													15	23					4.7546e-09	5.13753e-09	1	1	0
GREB1	9687	broad.mit.edu	37	2	11725952	11725952	+	Silent	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:11725952A>T	ENST00000381486.2	+	9	1380	c.1080A>T	c.(1078-1080)ccA>ccT	p.P360P	GREB1_ENST00000381483.2_Silent_p.P360P|GREB1_ENST00000234142.5_Silent_p.P360P|GREB1_ENST00000263834.5_Silent_p.P360P	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	360						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCACCTTTCCAGTGGTGGCCT	0.507000													32	65					0	0	1	0	0
ZIC2	7546	broad.mit.edu	37	13	100637229	100637229	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr13:100637229G>A	ENST00000376335.3	+	2	1398	c.1105G>A	c.(1105-1107)Ggc>Agc	p.G369S	ZIC2_ENST00000477213.1_3'UTR	NM_007129.3	NP_009060.2	O95409	ZIC2_HUMAN	Zic family member 2	369					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGAGTTTGAGGGCTGCGACCG	0.612000													16	33					0	0	1	0	0
CCDC82	79780	broad.mit.edu	37	11	96117453	96117453	+	Silent	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:96117453T>C	ENST00000278520.5	-	3	887	c.459A>G	c.(457-459)ttA>ttG	p.L153L	CCDC82_ENST00000423339.2_Silent_p.L153L|CCDC82_ENST00000542662.1_Silent_p.L153L			Q8N4S0	CCD82_HUMAN	coiled-coil domain containing 82	153							protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.154)		CCTCTTGACTTAAATGTTTTT	0.323000													36	161					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99681511	99681511	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:99681511C>T	ENST00000393483.3	-	16	2139	c.1295G>A	c.(1294-1296)cGt>cAt	p.R432H	TSGA10_ENST00000410001.1_Missense_Mutation_p.R432H|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000539964.1_Missense_Mutation_p.R432H|TSGA10_ENST00000355053.4_Missense_Mutation_p.R432H	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	432					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						CTCTGATTGACGGGCTTTATT	0.403000													39	124					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90021122	90021122	+	Silent	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:90021122G>T	ENST00000268122.4	-	6	989	c.921C>A	c.(919-921)ctC>ctA	p.L307L	RHCG_ENST00000544600.1_Silent_p.L307L	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	307					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					AGCCGATGATGAGGGCACCGT	0.617000													10	46					4.68919e-08	4.99973e-08	1	1	0
FAM84B	157638	broad.mit.edu	37	8	127568878	127568878	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr8:127568878C>T	ENST00000304916.3	-	2	1212	c.757G>A	c.(757-759)Gag>Aag	p.E253K		NM_174911.4	NP_777571.1	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	253						cytoplasm|plasma membrane	protein binding			lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			CGTCGCTTCTCCATGATCAGG	0.682000													9	10					0	0	1	0	0
GRIN3B	116444	broad.mit.edu	37	19	1004615	1004615	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:1004615G>T	ENST00000234389.3	+	3	1134	c.1115G>T	c.(1114-1116)aGc>aTc	p.S372I	GRIN3B_ENST00000588335.1_Intron	NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	372					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	AAGGTGTGGAGCCTTCGCCGG	0.706000													3	8					0.115264	0.115264	1	1	0
FGB	2244	broad.mit.edu	37	4	155487770	155487770	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr4:155487770C>T	ENST00000302068.4	+	3	499	c.436C>T	c.(436-438)Cag>Tag	p.Q146*	FGB_ENST00000502545.1_3'UTR|FGB_ENST00000509493.1_Intron	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	146				FQ -> QF (in Ref. 10; AA sequence, 11; AA sequence and 12; AA sequence).	platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TTCTTCCTTTCAGTACATGTA	0.403000													25	53					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107446571	107446571	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:107446571C>T	ENST00000409382.3	-	5	1879	c.1269G>A	c.(1267-1269)gaG>gaA	p.E423E	ST6GAL2_ENST00000361686.4_Silent_p.E423E|ST6GAL2_ENST00000409087.3_Silent_p.E423E	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	423					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.E423D(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CTTTAGTGTTCTCCTGGATAA	0.388000													30	89					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10084513	10084513	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrX:10084513C>T	ENST00000380861.4	+	10	1421	c.1030C>T	c.(1030-1032)Cgc>Tgc	p.R344C	WWC3_ENST00000454666.1_Missense_Mutation_p.R344C	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	344										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						AGAAGCCACCCGCTTAACATC	0.413000													25	58					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919923	12919923	+	Silent	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:12919923A>T	ENST00000240189.2	+	3	750	c.663A>T	c.(661-663)atA>atT	p.I221I		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	221										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACATCTGATAAGAAAGCTTT	0.383000													53	213					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205548961	205548961	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:205548961G>A	ENST00000367147.4	+	2	406	c.313G>A	c.(313-315)Gtg>Atg	p.V105M	MFSD4_ENST00000539267.1_Missense_Mutation_p.V105M|MFSD4_ENST00000536357.1_Missense_Mutation_p.V105M	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	105					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CTGCCGCGACGTGAAGGTGCT	0.627000													23	78					0	0	1	0	0
TCF3	6929	broad.mit.edu	37	19	1619317	1619317	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:1619317G>A	ENST00000262965.5	-	15	1668	c.1324C>T	c.(1324-1326)Ctg>Ttg	p.L442L	TCF3_ENST00000453954.2_Silent_p.L358L|TCF3_ENST00000344749.5_Silent_p.L442L|TCF3_ENST00000588136.1_Silent_p.L442L|TCF3_ENST00000395423.3_Silent_p.L391L	NM_003200.3	NP_003191.1	P15923	TFE2_HUMAN	transcription factor 3	442					B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCTCACCAGGCCTGCGTGC	0.741000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								4	4					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460189	107460189	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:107460189C>T	ENST00000409382.3	-	2	855	c.245G>A	c.(244-246)cGc>cAc	p.R82H	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.R82H|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.R82H	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	82					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						TGGGTGGGCGCGGGGCAGCGC	0.657000													19	57					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102736639	102736639	+	RNA	SNP	A	A	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:102736639A>C	ENST00000532855.1	-	0	1168							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CTCTGGTCTTAAATTGCTAAT	0.299000													9	31					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32912648	32912648	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr13:32912648G>A	ENST00000544455.1	+	11	4383	c.4156G>A	c.(4156-4158)Gat>Aat	p.D1386N	BRCA2_ENST00000380152.3_Missense_Mutation_p.D1386N	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1386					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGATTTGTCAGATTTAACTTT	0.338000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			14	37					0	0	1	0	0
ZIC3	7547	broad.mit.edu	37	X	136649786	136649786	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrX:136649786G>T	ENST00000287538.5	+	1	1486	c.936G>T	c.(934-936)aaG>aaT	p.K312N	ZIC3_ENST00000370606.3_Missense_Mutation_p.K312N	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	312	Nuclear localization signal.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					TCAAGGCGAAGTACAAACTGG	0.602000													86	25					1.42479e-40	1.68669e-40	1	1	0
SLC9A4	389015	broad.mit.edu	37	2	103142788	103142788	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:103142788G>T	ENST00000295269.4	+	11	2478	c.2021G>T	c.(2020-2022)aGg>aTg	p.R674M		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	674					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						AGAGACACAAGGGCTGCTGGG	0.537000													18	65					2.35188e-11	2.6114e-11	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228469780	228469780	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:228469780C>T	ENST00000570156.2	+	36	9705	c.9631C>T	c.(9631-9633)Cgc>Tgc	p.R3211C	OBSCN_ENST00000422127.1_Missense_Mutation_p.R2782C|OBSCN_ENST00000284548.11_Missense_Mutation_p.R2782C|OBSCN_ENST00000359599.6_Missense_Mutation_p.R1629C|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2245	Ig-like 32.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGCTCCAGCCGCTTCCAGGC	0.642000													3	31					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155020374	155020374	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:155020374G>A	ENST00000295542.1	+	15	1820	c.1724G>A	c.(1723-1725)cGg>cAg	p.R575Q	DCST1_ENST00000368419.2_Missense_Mutation_p.R575Q|DCST1_ENST00000392480.1_Missense_Mutation_p.R575Q|DCST1_ENST00000423025.2_Missense_Mutation_p.R550Q	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	575						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TACCGACTCCGGAGGGTCATC	0.602000													12	51					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105615349	105615349	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr14:105615349G>A	ENST00000331782.3	-	14	2234	c.1831C>T	c.(1831-1833)Cgc>Tgc	p.R611C	JAG2_ENST00000347004.2_Missense_Mutation_p.R573C	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	611	EGF-like 10; atypical.				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CTGACGCAGCGTCCATGGGGG	0.642000													6	14					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173998438	173998438	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:173998438G>T	ENST00000457714.1	+	7	2246	c.1817G>T	c.(1816-1818)tGg>tTg	p.W606L	NLGN1_ENST00000545397.1_Missense_Mutation_p.W606L|NLGN1_ENST00000401917.3_Missense_Mutation_p.W646L|NLGN1_ENST00000361589.4_Missense_Mutation_p.W606L	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	623					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GTGAACCTCTGGTTGGAGTTG	0.398000													42	128					1.22674e-20	1.4209e-20	1	1	0
CYLC1	1538	broad.mit.edu	37	X	83128916	83128916	+	Silent	SNP	A	A	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrX:83128916A>C	ENST00000329312.4	+	4	1237	c.1200A>C	c.(1198-1200)gcA>gcC	p.A400A		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	400					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						AAAAGGATGCAAAGAAAATTA	0.328000													4	12					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2783763	2783763	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr12:2783763C>T	ENST00000399655.1	+	39	5048	c.4783C>T	c.(4783-4785)Cgg>Tgg	p.R1595W	CACNA1C_ENST00000335762.5_Missense_Mutation_p.R1620W|CACNA1C_ENST00000399591.1_Missense_Mutation_p.R1603W|CACNA1C_ENST00000402845.3_Missense_Mutation_p.R1614W|CACNA1C_ENST00000399637.1_Missense_Mutation_p.R1614W|CACNA1C_ENST00000399617.1_Missense_Mutation_p.R1595W|CACNA1C_ENST00000399638.1_Missense_Mutation_p.R1623W|CACNA1C_ENST00000399601.1_Missense_Mutation_p.R1595W|CACNA1C_ENST00000399603.1_Missense_Mutation_p.R1595W|CACNA1C_ENST00000327702.7_Missense_Mutation_p.R1595W|CACNA1C_ENST00000399649.1_Missense_Mutation_p.R1601W|CACNA1C_ENST00000399641.1_Missense_Mutation_p.R1595W|CACNA1C_ENST00000344100.3_Missense_Mutation_p.R1636W|CACNA1C_ENST00000399629.1_Missense_Mutation_p.R1612W|CACNA1C_ENST00000399621.1_Missense_Mutation_p.R1614W|CACNA1C_ENST00000399644.1_Missense_Mutation_p.R1595W|CACNA1C_ENST00000399597.1_Missense_Mutation_p.R1595W|CACNA1C_ENST00000399634.1_Missense_Mutation_p.R1595W|CACNA1C_ENST00000347598.4_Missense_Mutation_p.R1643W|CACNA1C_ENST00000406454.3_Missense_Mutation_p.R1595W|CACNA1C_ENST00000399595.1_Missense_Mutation_p.R1603W|CACNA1C_ENST00000399606.1_Missense_Mutation_p.R1615W	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1643					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GATCTGGAAGCGGACCAGCAT	0.632000													4	21					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21252782	21252782	+	Silent	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:21252782A>G	ENST00000233242.1	-	11	1585	c.1458T>C	c.(1456-1458)taT>taC	p.Y486Y	APOB_ENST00000399256.4_Silent_p.Y486Y	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	486	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCAGAATCAAATAGGTGTAAT	0.443000													60	116					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94654553	94654553	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr12:94654553G>A	ENST00000258526.4	+	20	3636	c.3387G>A	c.(3385-3387)acG>acA	p.T1129T	PLXNC1_ENST00000551495.1_3'UTR|PLXNC1_ENST00000547057.1_Silent_p.T176T	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1129					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TGAGACGCACGGAGTCCGTCG	0.512000													15	42					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103955	53103955	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr7:53103955G>A	ENST00000408890.4	+	1	607	c.591G>A	c.(589-591)tgG>tgA	p.W197*		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	197										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GGCCGTTGTGGTTCGAGGTCT	0.672000													379	51					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1264578	1264578	+	Silent	SNP	T	T	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:1264578T>A	ENST00000447027.1	+	31	6535	c.6477T>A	c.(6475-6477)acT>acA	p.T2159T	MUC5B_ENST00000529681.1_Silent_p.T2156T|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2156	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ctgggacaactcccatccccc	0.647000													3	12					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33015677	33015677	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr10:33015677C>A	ENST00000375030.2	+	11	1148	c.530C>A	c.(529-531)tCt>tAt	p.S177Y	C10orf68_ENST00000375025.4_Missense_Mutation_p.S169Y|C10orf68_ENST00000375028.3_Missense_Mutation_p.S145Y			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	169										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						GATAAAAATTCTATGTTTGTT	0.294000													8	30					5.68852e-11	6.27296e-11	1	1	0
SEMA4G	57715	broad.mit.edu	37	10	102732925	102732925	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr10:102732925A>T	ENST00000210633.3	+	2	242	c.164A>T	c.(163-165)aAc>aTc	p.N55I	SEMA4G_ENST00000519756.1_3'UTR|SEMA4G_ENST00000517724.1_Missense_Mutation_p.N55I|SEMA4G_ENST00000370250.4_Missense_Mutation_p.N55I			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	55	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CAAGCCCAGAACTACTCAACA	0.637000													11	33					0	0	1	0	0
EDN1	1906	broad.mit.edu	37	6	12296207	12296207	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:12296207G>A	ENST00000379375.5	+	5	813	c.546G>A	c.(544-546)atG>atA	p.M182I		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	182					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				CGGAGACCATGAGAAACAGCG	0.403000													125	112					0	0	1	0	0
GOLGA6L17P	642402	broad.mit.edu	37	15	85053124	85053124	+	RNA	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:85053124G>T	ENST00000414190.2	-	0	328					NR_003246.2																						TAAATGTTTTGTTTTTTTTTT	0.353000													8	32					0.000442599	0.000451003	1	1	0
HSPH1	10808	broad.mit.edu	37	13	31713028	31713028	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr13:31713028T>A	ENST00000320027.5	-	16	2442	c.2098A>T	c.(2098-2100)Act>Tct	p.T700S	HSPH1_ENST00000380406.5_Missense_Mutation_p.T659S|HSPH1_ENST00000429785.2_Missense_Mutation_p.T519S|HSPH1_ENST00000380405.4_Missense_Mutation_p.T656S|HSPH1_ENST00000445273.2_Missense_Mutation_p.T702S	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	700					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TTAACTGGAGTGCCAATTTTC	0.338000													54	43					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35655077	35655077	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:35655077C>T	ENST00000342879.3	+	5	1089	c.311C>T	c.(310-312)aCc>aTc	p.T104I	FXYD5_ENST00000423817.3_Missense_Mutation_p.T104I|FXYD5_ENST00000392219.2_Missense_Mutation_p.T104I|FXYD5_ENST00000543307.1_Missense_Mutation_p.T104I|FXYD5_ENST00000541435.2_Missense_Mutation_p.T104I|FXYD5_ENST00000590686.1_Missense_Mutation_p.T104I|FXYD5_ENST00000591716.2_3'UTR|FXYD5_ENST00000392217.3_Missense_Mutation_p.T33I|FXYD5_ENST00000588699.1_Missense_Mutation_p.T104I			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	104					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			ACTGATGACACCACGACGCTC	0.557000													13	41					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28326985	28326985	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:28326985G>A	ENST00000354638.3	-	2	191	c.36C>T	c.(34-36)ccC>ccT	p.P12P	OCA2_ENST00000382996.2_Silent_p.P12P|OCA2_ENST00000353809.5_Silent_p.P12P	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	12					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CCGGCGCGCCGGGGTACCGCC	0.652000									Oculocutaneous Albinism				4	32					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148039927	148039927	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrX:148039927A>G	ENST00000370460.2	+	12	3108	c.2629A>G	c.(2629-2631)Atc>Gtc	p.I877V	AFF2_ENST00000286437.5_Missense_Mutation_p.I518V|AFF2_ENST00000342251.3_Missense_Mutation_p.I844V|AFF2_ENST00000370457.5_Missense_Mutation_p.I844V	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	877					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCACAACTATCTGCTTGCT	0.512000													148	33					0	0	1	0	0
TRPC4AP	26133	broad.mit.edu	37	20	33680571	33680571	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr20:33680571G>A	ENST00000252015.2	-	1	103	c.14C>T	c.(13-15)cCg>cTg	p.P5L	TRPC4AP_ENST00000432634.2_Missense_Mutation_p.P5L|TRPC4AP_ENST00000451813.1_Missense_Mutation_p.P5L			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	5	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding	p.P5L(1)		breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGCCGCTACCGGCGCCGCCGC	0.741000													9	12					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5772958	5772958	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:5772958C>T	ENST00000381624.3	+	20	1984	c.1923C>T	c.(1921-1923)ccC>ccT	p.P641P	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	641						integral to membrane											TCGGGGGGCCCTTCTTCTGGA	0.587000													11	25					0	0	1	0	0
LCP2	3937	broad.mit.edu	37	5	169689739	169689739	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr5:169689739C>A	ENST00000046794.5	-	13	1441	c.826G>T	c.(826-828)Ggg>Tgg	p.G276W	LCP2_ENST00000521416.1_Missense_Mutation_p.G71W	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	276					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		AAATGCTCCCCGAGTGACCTG	0.507000													22	27					7.45023e-12	8.32977e-12	1	1	0
SPINT4	391253	broad.mit.edu	37	20	44352533	44352533	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr20:44352533G>A	ENST00000279058.3	+	2	147	c.130G>A	c.(130-132)Gac>Aac	p.D44N		NM_178455.1	NP_848550.1	Q6UDR6	SPIT4_HUMAN	serine peptidase inhibitor, Kunitz type 4	44	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			lung(6)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.028)				CTGCAAATTGGACATGAATTT	0.408000													24	134					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362799	105362799	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr10:105362799C>T	ENST00000369774.4	-	15	2452	c.2176G>A	c.(2176-2178)Gca>Aca	p.A726T	SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.A593T|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.A561T|SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.A698T|SH3PXD2A_ENST00000427662.2_Intron			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	726					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CGGATGCCTGCGTCCGAAGCA	0.617000													21	92					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27237893	27237893	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr7:27237893C>A	ENST00000222753.4	-	2	1119	c.1091G>T	c.(1090-1092)cGg>cTg	p.R364L		NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	364					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						TGTGACCTGCCGCTCAGAGAG	0.413000			T	NUP98	AML								76	291					1.1397e-45	1.36934e-45	1	1	0
DBF4B	80174	broad.mit.edu	37	17	42786728	42786728	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:42786728G>A	ENST00000315005.3	+	2	214	c.76G>A	c.(76-78)Gac>Aac	p.D26N	DBF4B_ENST00000526915.1_Intron|DBF4B_ENST00000398338.3_Missense_Mutation_p.D26N|DBF4B_ENST00000393547.2_Missense_Mutation_p.D26N	NM_145663.2	NP_663696.1	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B (S. cerevisiae)	26					cell cycle	nucleus	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)	7		Prostate(33;0.0322)				CCGGGCCCCGGACCTAGGTGG	0.537000													7	341					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40959707	40959707	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr5:40959707A>T	ENST00000313164.9	+	12	2005	c.1646A>T	c.(1645-1647)gAg>gTg	p.E549V		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	549	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				GAAGATGAGGAGCTGGAGCAC	0.522000													15	19					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097175	167097175	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:167097175A>T	ENST00000361200.2	+	6	2973	c.2807A>T	c.(2806-2808)aAt>aTt	p.N936I	DUSP27_ENST00000443333.1_Missense_Mutation_p.N936I|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.N936I			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	936	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGCAGTATTAATAAGTGGCTC	0.502000													12	20					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1265999	1265999	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:1265999T>C	ENST00000447027.1	+	31	7956	c.7898T>C	c.(7897-7899)cTt>cCt	p.L2633P	MUC5B_ENST00000529681.1_Missense_Mutation_p.L2630P|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2630	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.L2630P(1)|p.L2609P(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCACGCACGCTTCCAGTGTGG	0.637000													4	107					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14832660	14832660	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrY:14832660A>T	ENST00000338981.3	+	4	1180	c.235A>T	c.(235-237)Atg>Ttg	p.M79L	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	79					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CCTGGATGACATGATCAACAG	0.428000													32	35					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245530315	245530315	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:245530315C>G	ENST00000407071.2	+	3	1085	c.645C>G	c.(643-645)gaC>gaG	p.D215E	KIF26B_ENST00000479506.1_3'UTR	NM_018012.3	NP_060482.2	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	215					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGCACTACGACGCCTCGCCCT	0.657000													8	17					0	0	1	0	0
OR10A4	283297	broad.mit.edu	37	11	6898608	6898608	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:6898608G>A	ENST00000379829.2	+	1	753	c.730G>A	c.(730-732)Gcc>Acc	p.A244T		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A244T(2)		kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CACCTGTTCCGCCCACCTCTT	0.527000													32	76					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151337669	151337669	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:151337669A>G	ENST00000426705.2	-	10	1403	c.1259T>C	c.(1258-1260)gTc>gCc	p.V420A	SELENBP1_ENST00000447402.3_Missense_Mutation_p.V316A|SELENBP1_ENST00000368868.5_Missense_Mutation_p.V378A|SELENBP1_ENST00000435071.1_Missense_Mutation_p.V314A	NM_001258289.1	NP_001245218.1	Q13228	SBP1_HUMAN	selenium binding protein 1	378					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTTACCTTGACCACTAGGGG	0.582000													4	22					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104119951	104119951	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr10:104119951G>T	ENST00000369983.3	+	12	1448	c.1188G>T	c.(1186-1188)ttG>ttT	p.L396F	GBF1_ENST00000476019.1_Intron	NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	396					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GCACAGCTTTGGTCCCCTATG	0.527000													106	339					7.35891e-43	8.77618e-43	1	1	0
DDX28	55794	broad.mit.edu	37	16	68056207	68056207	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr16:68056207A>T	ENST00000332395.5	-	1	1563	c.899T>A	c.(898-900)gTg>gAg	p.V300E		NM_018380.3	NP_060850.2	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	300	Helicase ATP-binding.					mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		GATGTAGTCCACCAGTTCCAG	0.507000													23	91					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77973178	77973178	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr7:77973178C>A	ENST00000354212.4	-	9	1578	c.1325G>T	c.(1324-1326)gGt>gTt	p.G442V	MAGI2_ENST00000536571.1_Missense_Mutation_p.G274V|MAGI2_ENST00000419488.1_Missense_Mutation_p.G442V|MAGI2_ENST00000535697.1_Missense_Mutation_p.G279V|MAGI2_ENST00000522391.1_Missense_Mutation_p.G442V	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	442	PDZ 2.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTCGTCTCCACCAATGATGGT	0.488000													11	35					9.70103e-10	1.05531e-09	1	1	0
TPP2	7174	broad.mit.edu	37	13	103249403	103249403	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr13:103249403G>A	ENST00000376052.3	+	1	31	c.15G>A	c.(13-15)gcG>gcA	p.A5A	TPP2_ENST00000376065.4_Silent_p.A5A			P29144	TPP2_HUMAN	tripeptidyl peptidase II	5					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCACCGCTGCGACTGAGGAGC	0.687000													6	13					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203329550	203329550	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:203329550G>A	ENST00000374580.4	+	2	634	c.95G>A	c.(94-96)cGg>cAg	p.R32Q	BMPR2_ENST00000374574.2_Missense_Mutation_p.R32Q|BMPR2_ENST00000479069.1_3'UTR	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	32					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						AATCAAGAACGGCTATGTGCG	0.343000													36	36					0	0	1	0	0
NCLN	56926	broad.mit.edu	37	19	3207443	3207443	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:3207443C>T	ENST00000246117.4	+	14	2039	c.1608C>T	c.(1606-1608)ctC>ctT	p.L536L	NCLN_ENST00000590671.1_Silent_p.L462L	NM_020170.3	NP_064555.2	Q969V3	NCLN_HUMAN	nicalin	536					proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCCTACCTCGGCATGGCCT	0.672000													54	108					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183944297	183944297	+	Silent	SNP	G	G	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:183944297G>C	ENST00000361927.4	-	3	797	c.426C>G	c.(424-426)gcC>gcG	p.A142A	COLGALT2_ENST00000546159.1_Silent_p.A142A	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		TCATCACATGGGCAAACCGGG	0.428000													14	113					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634203	70634203	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr14:70634203G>A	ENST00000381269.2	-	2	1690	c.937C>T	c.(937-939)Cgc>Tgc	p.R313C	SLC8A3_ENST00000356921.2_Missense_Mutation_p.R313C|SLC8A3_ENST00000357887.3_Missense_Mutation_p.R313C|SLC8A3_ENST00000528359.1_Missense_Mutation_p.R313C|SLC8A3_ENST00000534137.1_Missense_Mutation_p.R313C	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	313					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ATCTCTCTGCGGGACTCATCC	0.488000													37	79					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47287699	47287699	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:47287699C>A	ENST00000335044.2	-	13	1634	c.1277G>T	c.(1276-1278)cGg>cTg	p.R426L	KIF9_ENST00000452770.2_Missense_Mutation_p.R426L|KIF9_ENST00000265529.3_Missense_Mutation_p.R426L|KIF9_ENST00000352910.4_Missense_Mutation_p.R333L|KIF9-AS1_ENST00000429315.3_RNA|KIF9_ENST00000487440.1_5'UTR|KIF9_ENST00000444589.2_Missense_Mutation_p.R426L	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9	426					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CAGAACCACCCGGAACTGGTT	0.562000													5	22					0.0215528	0.0218239	1	1	0
DCAF11	80344	broad.mit.edu	37	14	24592244	24592244	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr14:24592244C>T	ENST00000558325.1	+	2	232	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C	DCAF11_ENST00000559115.1_Silent_p.D488D|DCAF11_ENST00000446197.3_Silent_p.D488D|DCAF11_ENST00000396941.4_Silent_p.D462D|DCAF11_ENST00000396936.1_Silent_p.D388D																							GTGTGCGTGACGTCAGTTGGC	0.562000													16	82					0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31118256	31118256	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:31118256C>T	ENST00000396268.3	-	7	1376	c.1188G>A	c.(1186-1188)ctG>ctA	p.L396L	CCHCR1_ENST00000376266.5_Silent_p.L307L|CCHCR1_ENST00000451521.2_Silent_p.L360L|CCHCR1_ENST00000396263.2_Silent_p.L307L|CCHCR1_ENST00000480060.1_Intron	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	307					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						CCTCCTCCTGCAGGGCGAGGA	0.672000													7	38					0	0	1	0	0
CPNE9	151835	broad.mit.edu	37	3	9754511	9754511	+	Splice_Site	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:9754511A>G	ENST00000383832.3	+	9	734	c.545_splice	c.e9+1	p.T182_splice	CPNE9_ENST00000383831.3_Splice_Site_p.T182_splice	NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	182	C2 2.									breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					TGAGGATGGCACGTGAGTCAC	0.517000													19	37					0	0	1	0	0
CDK5RAP1	51654	broad.mit.edu	37	20	31975138	31975138	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr20:31975138G>T	ENST00000357886.4	-	6	899	c.746C>A	c.(745-747)tCt>tAt	p.S249Y	CDK5RAP1_ENST00000544843.1_Missense_Mutation_p.S249Y|CDK5RAP1_ENST00000339269.5_Missense_Mutation_p.S249Y|CDK5RAP1_ENST00000452723.3_Missense_Mutation_p.S159Y|CDK5RAP1_ENST00000346416.2_Missense_Mutation_p.S249Y|CDK5RAP1_ENST00000473997.1_5'UTR			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	249					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						CACAAAGGCAGACGTGGCACT	0.507000													19	30					7.21436e-19	8.29652e-19	1	1	0
CD2	914	broad.mit.edu	37	1	117297443	117297443	+	Nonsense_Mutation	SNP	T	T	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:117297443T>A	ENST00000369478.3	+	2	360	c.252T>A	c.(250-252)taT>taA	p.Y84*	CD2_ENST00000369477.1_Nonsense_Mutation_p.Y84*	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	84	Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	AAGATACATATAAGCTATTTA	0.299000													17	35					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92908448	92908448	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr14:92908448G>A	ENST00000532405.1	+	5	635	c.409G>A	c.(409-411)Gaa>Aaa	p.E137K	SLC24A4_ENST00000531433.1_Missense_Mutation_p.E137K|SLC24A4_ENST00000351924.5_Missense_Mutation_p.E120K|SLC24A4_ENST00000393265.2_Missense_Mutation_p.E73K|SLC24A4_ENST00000298877.1_Missense_Mutation_p.E120K			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	137						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCATCTGAGCGAAGATGTGGC	0.557000													12	61					0	0	1	0	0
CASKIN2	57513	broad.mit.edu	37	17	73498857	73498857	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:73498857C>T	ENST00000321617.3	-	18	2884	c.2298G>A	c.(2296-2298)ccG>ccA	p.P766P	CASKIN2_ENST00000433559.2_Silent_p.P684P	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	766	Pro-rich.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCCTGGGGCCGGGCTAGAGG	0.667000													15	28					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986505	61986505	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr13:61986505G>T	ENST00000409186.1	-	5	3832	c.1727C>A	c.(1726-1728)cCt>cAt	p.P576H	PCDH20_ENST00000409204.4_Missense_Mutation_p.P576H			Q8N6Y1	PCD20_HUMAN	protocadherin 20	549	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TGGAGCATCAGGTCCCAGAAA	0.443000													18	102					1.99824e-07	2.11655e-07	1	1	0
OR4D2	124538	broad.mit.edu	37	17	56247582	56247582	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:56247582G>A	ENST00000545221.1	+	1	566	c.566G>A	c.(565-567)tGc>tAc	p.C189Y		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						AGACTTGCCTGCACTGACACC	0.512000													4	111					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155234038	155234038	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:155234038G>A	ENST00000368361.4	-	11	1515	c.1200C>T	c.(1198-1200)atC>atT	p.I400I	CLK2_ENST00000536801.1_Silent_p.I400I|CLK2_ENST00000355560.4_Silent_p.I398I|CLK2_ENST00000361168.5_Silent_p.I399I|CLK2_ENST00000497188.1_5'UTR			P49760	CLK2_HUMAN	CDC-like kinase 2	400	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCCGGGAAGGGATAGGACCCA	0.458000								Other conserved DNA damage response genes					14	63					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17272863	17272863	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:17272863C>T	ENST00000375541.5	+	16	2315	c.2246C>T	c.(2245-2247)gCt>gTt	p.A749V	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	749					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GAGAGCCTTGCTCAGGACAAG	0.652000													16	51					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111697739	111697739	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:111697739C>T	ENST00000435970.1	-	15	2401	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	REV3L_ENST00000368802.3_Missense_Mutation_p.E607K|REV3L_ENST00000358835.3_Missense_Mutation_p.E607K|REV3L_ENST00000368805.1_Missense_Mutation_p.E607K			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	607					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGACCTTTTTCTGTATTTTTG	0.338000								DNA polymerases (catalytic subunits)					17	39					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10399294	10399294	+	Silent	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:10399294A>G	ENST00000226207.5	-	35	5236	c.5142T>C	c.(5140-5142)agT>agC	p.S1714S	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1714						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GAACACGCTCACTGGCATCCA	0.502000													21	67					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1416304	1416304	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr5:1416304C>G	ENST00000270349.9	-	7	1067	c.940G>C	c.(940-942)Gcg>Ccg	p.A314P	SLC6A3_ENST00000453492.2_Missense_Mutation_p.A314P	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	314					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TGGGTGGCCGCGTCAATCCAA	0.627000													4	50					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58889782	58889782	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:58889782G>A	ENST00000260408.3	-	16	2654	c.2211C>T	c.(2209-2211)ccC>ccT	p.P737P	ADAM10_ENST00000396140.2_Silent_p.P436P|ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000561288.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	737					cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		AACTCTCTCGGGGCCGCTGAC	0.473000													27	38					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650774	55650774	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrX:55650774C>T	ENST00000339140.3	+	1	942	c.630C>T	c.(628-630)caC>caT	p.H210H		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	210					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.H210H(1)		biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						ACAACCCCCACTGTGGCCTCA	0.498000													29	35					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132180004	132180004	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:132180004G>A	ENST00000260818.6	+	15	1916	c.1668G>A	c.(1666-1668)ttG>ttA	p.L556L	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	556							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						ATATGCTCTTGGAGATGGTAG	0.423000													63	136					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101627475	101627475	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:101627475A>T	ENST00000409318.1	-	19	3061	c.2931T>A	c.(2929-2931)gaT>gaA	p.D977E	RPL31_ENST00000409028.4_Intron|RPL31_ENST00000409650.1_Intron|RPL31_ENST00000409038.1_Intron|TBC1D8_ENST00000376840.4_Missense_Mutation_p.D962E	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	962				EKD -> KKK (in Ref. 1; BAA76517).	blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						GTTTCTGATAATCAACTGCAT	0.353000													21	72					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236826	140236826	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr5:140236826C>A	ENST00000307360.5	+	1	1193	c.1193C>A	c.(1192-1194)tCc>tAc	p.S398Y	PCDHA10_ENST00000506939.2_Missense_Mutation_p.S398Y|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1												p.S398F(2)		NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCTGGTGTCCACCTACAAG	0.597000													36	129					2.42023e-17	2.76353e-17	1	1	0
TRIM27	5987	broad.mit.edu	37	6	28872268	28872268	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:28872268T>A	ENST00000377199.3	-	8	1477	c.1121A>T	c.(1120-1122)gAg>gTg	p.E374V	TRIM27_ENST00000377194.3_Intron	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	374	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						CACCTCTACCTCCCAATAATG	0.527000			T	RET	papillary thyroid								4	72					0	0	1	0	0
FNBP1	23048	broad.mit.edu	37	9	132658259	132658259	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr9:132658259C>T	ENST00000420781.1	-	16	1895	c.1677G>A	c.(1675-1677)acG>acA	p.T559T	FNBP1_ENST00000446176.2_Silent_p.T568T|FNBP1_ENST00000443566.2_Silent_p.T196T|FNBP1_ENST00000355681.3_Silent_p.T539T			Q96RU3	FNBP1_HUMAN	formin binding protein 1	568	Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.|Interaction with DNM1 and DNM3.|Interaction with DNM2 and WASL.|Interaction with FASLG.|Interaction with PDE6G (By similarity).|Required for interaction with TNKS.|Required for self-association and induction of membrane tubulation.|SH3.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding	p.T568T(1)					Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		CTACGGAAATCGTTCCTTCAT	0.443000			T	MLL	AML								15	43					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32996151	32996151	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr12:32996151G>C	ENST00000070846.6	-	6	1499	c.1475C>G	c.(1474-1476)aCg>aGg	p.T492R	PKP2_ENST00000340811.4_Intron	NM_004572.3	NP_004563.2	Q99959	PKP2_HUMAN	plakophilin 2	492					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					tcctgacctcgtgatccgccc	0.547000													13	11					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31741062	31741062	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr22:31741062C>T	ENST00000266269.5	-	1	1156	c.527G>A	c.(526-528)cGc>cAc	p.R176H	PATZ1_ENST00000351933.4_Missense_Mutation_p.R176H|PATZ1_ENST00000405309.3_Missense_Mutation_p.R176H|PATZ1_ENST00000215919.3_Missense_Mutation_p.R176H	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	176					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						CCCAGGGGGGCGAAAGAGCAT	0.592000													32	93					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32098724	32098724	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr5:32098724C>T	ENST00000438447.1	+	23	8590	c.8202C>T	c.(8200-8202)ccC>ccT	p.P2734P	PDZD2_ENST00000282493.3_Silent_p.P2734P			O15018	PDZD2_HUMAN	PDZ domain containing 2	2734					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AGACCATCCCCCTGGAGCCTG	0.527000													4	35					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59431	59431	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr4:59431A>T	ENST00000509152.2	+	2	297	c.112A>T	c.(112-114)Agg>Tgg	p.R38W	ZNF595_ENST00000526473.2_Missense_Mutation_p.R38W|ZNF595_ENST00000339368.6_3'UTR					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		GGAGAACTACAGGAACCTGGT	0.433000													40	808					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175877	57175877	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:57175877C>T	ENST00000537055.2	-	2	921	c.690G>A	c.(688-690)gcG>gcA	p.A230A		NM_001005850.2	NP_001005850.2			zinc finger protein 835									p.A252A(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						GGTTGCGGAACGCCTTGGCGC	0.697000													11	30					0	0	1	0	0
HEATR3	55027	broad.mit.edu	37	16	50102745	50102745	+	Silent	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr16:50102745T>C	ENST00000299192.7	+	3	557	c.366T>C	c.(364-366)gaT>gaC	p.D122D	HEATR3_ENST00000285767.4_Silent_p.D36D	NM_182922.2	NP_891552.1	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	122							binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						TGACTAAGGATATCATGACCC	0.373000													47	182					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211093339	211093339	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:211093339C>T	ENST00000367007.4	-	7	1193	c.1024G>A	c.(1024-1026)Gac>Aac	p.D342N	KCNH1_ENST00000271751.4_Missense_Mutation_p.D369N	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	369					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ATGTAGTGGTCCAGCTTACGG	0.577000													19	75					0	0	1	0	0
SH3D19	152503	broad.mit.edu	37	4	152065407	152065407	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr4:152065407T>C	ENST00000304527.4	-	12	2365	c.1276A>G	c.(1276-1278)Att>Gtt	p.I426V	SH3D19_ENST00000409252.2_Missense_Mutation_p.I426V|SH3D19_ENST00000409598.4_Intron|SH3D19_ENST00000424281.1_Intron|SH3D19_ENST00000427414.2_Intron|SH3D19_ENST00000455740.1_Intron|SH3D19_ENST00000514152.1_Intron	NM_001009555.3	NP_001009555.3	Q5HYK7	SH319_HUMAN	SH3 domain containing 19	426	SH3 1.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(1)|skin(3)|urinary_tract(1)	20	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TGAGAGACAATATCTTCATTG	0.368000													30	106					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34804007	34804007	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:34804007C>A	ENST00000192788.5	+	8	1086	c.915C>A	c.(913-915)agC>agA	p.S305R	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.S305R	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	305										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						ACAGCAACAGCAGCAGCAGCC	0.552000													84	150					6.44082e-31	7.56914e-31	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25446507	25446507	+	RNA	SNP	G	G	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:25446507G>C	ENST00000424208.1	+	0	1988				SNHG14_ENST00000424333.1_RNA|SNORD115-17_ENST00000364612.1_RNA	NR_003305.1																						CCTGAAGAGAGGTGATGACTT	0.502000													72	392					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27353504	27353504	+	Nonsense_Mutation	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr16:27353504G>T	ENST00000395762.2	+	4	392	c.133G>T	c.(133-135)Gag>Tag	p.E45*	IL4R_ENST00000449195.1_Nonsense_Mutation_p.E45*|IL4R_ENST00000543915.2_Nonsense_Mutation_p.E45*|IL4R_ENST00000380922.3_Nonsense_Mutation_p.E30*|IL4R_ENST00000170630.2_Nonsense_Mutation_p.E45*	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	45					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						CTCTACTTGCGAGTGGAAGAT	0.587000													29	63					3.73148e-12	4.20117e-12	1	1	0
ACOX3	8310	broad.mit.edu	37	4	8407729	8407729	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr4:8407729C>T	ENST00000356406.5	-	7	806	c.729G>A	c.(727-729)atG>atA	p.M243I	ACOX3_ENST00000413009.2_Missense_Mutation_p.M243I|ACOX3_ENST00000503233.1_Missense_Mutation_p.M243I	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	243					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						TGTCGCCAACCATCACTCCAG	0.517000													56	272					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368994	86368994	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr13:86368994C>T	ENST00000400286.2	-	2	2248	c.1650G>A	c.(1648-1650)ggG>ggA	p.G550G		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	550	LRRCT 2.					integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TGTCGAGATGCCCGGGGGAAG	0.463000													4	74					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202913030	202913030	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:202913030C>A	ENST00000340990.5	-	6	959	c.661G>T	c.(661-663)Gtc>Ttc	p.V221F	ADIPOR1_ENST00000436244.1_Missense_Mutation_p.V221F|ADIPOR1_ENST00000367254.3_Intron	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	221					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			AGCCAGGGGACAAAGCTCCCC	0.468000													6	27					0.0293803	0.029564	1	1	0
COLEC11	78989	broad.mit.edu	37	2	3660936	3660936	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:3660936G>A	ENST00000403096.3	+	2	579	c.88G>A	c.(88-90)Gga>Aga	p.G30R	COLEC11_ENST00000236693.7_Silent_p.P26P|COLEC11_ENST00000418971.2_Missense_Mutation_p.G70R|COLEC11_ENST00000487365.1_Intron|COLEC11_ENST00000404205.1_Intron|COLEC11_ENST00000402794.1_Intron|COLEC11_ENST00000402922.1_Missense_Mutation_p.G30R|COLEC11_ENST00000382062.2_Missense_Mutation_p.G56R|COLEC11_ENST00000349077.4_Missense_Mutation_p.G56R	NM_001255986.1	NP_001242915.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	56						collagen	mannose binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		AGGCGCCCCCGGACGGCCTGG	0.622000													3	18					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90106618	90106618	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr5:90106618G>C	ENST00000405460.2	+	74	15637	c.15541G>C	c.(15541-15543)Gag>Cag	p.E5181Q	GPR98_ENST00000425867.2_Missense_Mutation_p.E842Q	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5181					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CATTGTTACTGAGGCAACTGG	0.493000													36	30					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38185713	38185713	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:38185713C>T	ENST00000373048.4	-	14	2429	c.2430G>A	c.(2428-2430)gcG>gcA	p.A810A	EPHA10_ENST00000540011.1_3'UTR|EPHA10_ENST00000330210.7_Silent_p.A305A|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000427468.2_Silent_p.A810A	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	810	Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGGCCCATAGCGCTGGGCTCC	0.632000													9	38					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77973179	77973179	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr7:77973179C>A	ENST00000354212.4	-	9	1577	c.1324G>T	c.(1324-1326)Ggt>Tgt	p.G442C	MAGI2_ENST00000536571.1_Missense_Mutation_p.G274C|MAGI2_ENST00000419488.1_Missense_Mutation_p.G442C|MAGI2_ENST00000535697.1_Missense_Mutation_p.G279C|MAGI2_ENST00000522391.1_Missense_Mutation_p.G442C	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	442	PDZ 2.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TCGTCTCCACCAATGATGGTA	0.488000													11	35					9.70103e-10	1.05531e-09	1	1	0
TTC25	83538	broad.mit.edu	37	17	40091513	40091513	+	RNA	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:40091513G>T	ENST00000591658.1	+	0	226							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CTGGTTGCTCGCTCAAAGTGC	0.517000													8	38					1.12685e-05	1.17807e-05	1	1	0
SYT6	148281	broad.mit.edu	37	1	114680204	114680204	+	Silent	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr1:114680204A>G	ENST00000393296.1	-	3	1061	c.984T>C	c.(982-984)atT>atC	p.I328I	SYT6_ENST00000369547.1_Silent_p.I243I			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	328	C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGACCTCGCCAATCATGTCAT	0.532000													20	32					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536343	74536343	+	Splice_Site	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:74536343G>A	ENST00000321288.5	+	4	648		c.e4-1		CCDC33_ENST00000398814.3_Silent_p.E13E			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33								protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AAGACCCAGAGGAGCCCCTGA	0.552000													32	122					0	0	1	0	0
MLEC	9761	broad.mit.edu	37	12	121125273	121125273	+	Silent	SNP	G	G	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr12:121125273G>T	ENST00000228506.3	+	1	602	c.174G>T	c.(172-174)gcG>gcT	p.A58A	MLEC_ENST00000412616.2_Silent_p.A58A	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	58					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						GTGGAGAGGCGCATGTGGACG	0.746000													19	16					3.51602e-12	3.98647e-12	1	1	0
BTAF1	9044	broad.mit.edu	37	10	93744029	93744029	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr10:93744029C>T	ENST00000265990.6	+	19	2603	c.2295C>T	c.(2293-2295)gaC>gaT	p.D765D	BTAF1_ENST00000471217.1_3'UTR	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	765					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				TATATTATGACGAAATTGCCG	0.348000													18	45					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37357241	37357241	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr20:37357241G>A	ENST00000217420.1	+	2	1800	c.1537G>A	c.(1537-1539)Gag>Aag	p.E513K		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	513					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GCACTCCCTCGAGGGCCTCAT	0.667000													5	30					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170066058	170066058	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:170066058C>T	ENST00000263816.3	-	38	6659	c.6374G>A	c.(6373-6375)cGt>cAt	p.R2125H		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2125					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTTAATTCTACGGATCGCATT	0.453000													18	84					0	0	1	0	0
CEACAM16	388551	broad.mit.edu	37	19	45206848	45206848	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr19:45206848C>T	ENST00000587331.1	+	3	482	c.267C>T	c.(265-267)ccC>ccT	p.P89P	CEACAM16_ENST00000405314.2_Silent_p.P89P|CTB-171A8.1_ENST00000590796.1_RNA	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	89										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				CTGTGCGCCCCGATGGCAGCC	0.662000													25	12					0	0	1	0	0
FAM107B	83641	broad.mit.edu	37	10	14563887	14563887	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr10:14563887C>T	ENST00000181796.2	-	4	1018	c.785G>A	c.(784-786)cGg>cAg	p.R262Q	FAM107B_ENST00000378470.1_Missense_Mutation_p.R87Q|FAM107B_ENST00000378467.4_Missense_Mutation_p.R87Q|FAM107B_ENST00000496330.1_Missense_Mutation_p.R87Q|FAM107B_ENST00000468747.1_Missense_Mutation_p.R87Q|FAM107B_ENST00000378462.1_Missense_Mutation_p.R87Q|FAM107B_ENST00000378458.2_Missense_Mutation_p.R87Q|FAM107B_ENST00000478076.1_Missense_Mutation_p.R87Q|FAM107B_ENST00000378465.3_Missense_Mutation_p.R87Q|FAM107B_ENST00000479731.1_Missense_Mutation_p.R87Q	NM_031453.2	NP_113641.2	Q9H098	F107B_HUMAN	family with sequence similarity 107, member B	87										breast(7)|kidney(1)|large_intestine(4)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CTTCTGCTGCCGTTTTAATAG	0.423000													20	98					0	0	1	0	0
C6orf25	80739	broad.mit.edu	37	6	31691724	31691724	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:31691724G>C	ENST00000375809.3	+	2	381	c.370G>C	c.(370-372)Ggg>Cgg	p.G124R	C6orf25_ENST00000480039.1_Missense_Mutation_p.G124R|C6orf25_ENST00000375810.4_Missense_Mutation_p.G124R|C6orf25_ENST00000375805.2_Missense_Mutation_p.G124R	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	124						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TCACGTGCTGGGGGACAGGAC	0.632000													21	141					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891831	18891831	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr12:18891831A>G	ENST00000317658.3	+	1	787	c.629A>G	c.(628-630)aAa>aGa	p.K210R		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	210					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				AAGGACCTGAAAGAAAGCTTG	0.403000													17	80					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202082352	202082352	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:202082352A>T	ENST00000286186.6	+	10	1892	c.1457A>T	c.(1456-1458)gAt>gTt	p.D486V	CASP10_ENST00000360132.3_3'UTR|CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000448480.1_Intron|CASP10_ENST00000313728.7_Missense_Mutation_p.D419V|CASP10_ENST00000346817.5_Missense_Mutation_p.D443V|CASP10_ENST00000272879.5_Intron	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	0					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						GTCAACGATGATGTGAGTCGA	0.448000													20	90					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83451772	83451772	+	Silent	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:83451772A>G	ENST00000334574.8	-	4	922	c.741T>C	c.(739-741)aaT>aaC	p.N247N	FSD2_ENST00000541889.1_Silent_p.N247N			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	247										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						GTTTTCCAAAATTCTCCTGCA	0.338000													107	47					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86493656	86493656	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr7:86493656C>G	ENST00000394720.2	+	5	1729	c.1552C>G	c.(1552-1554)Cac>Gac	p.H518D	GRM3_ENST00000536043.1_Silent_p.T747T|GRM3_ENST00000439827.1_Missense_Mutation_p.H520D|GRM3_ENST00000546348.1_Silent_p.T467T|GRM3_ENST00000361669.2_Silent_p.T875T			Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	0					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TCGACTCCACCACCTCATCTC	0.463000													35	83					0	0	1	0	0
KAT2A	2648	broad.mit.edu	37	17	40272335	40272335	+	Silent	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:40272335G>A	ENST00000225916.5	-	3	570	c.517C>T	c.(517-519)Ctg>Ttg	p.L173L	CTD-2132N18.3_ENST00000592574.1_Silent_p.L207L	NM_021078.2	NP_066564.2	Q92830	KAT2A_HUMAN	K(lysine) acetyltransferase 2A	173					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						ACCATCCCCAGCAGTCGGTTT	0.458000													21	60					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13522936	13522936	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr10:13522936C>T	ENST00000341083.3	-	6	1166	c.870G>A	c.(868-870)cgG>cgA	p.R290R	BEND7_ENST00000396900.2_Silent_p.R342R|BEND7_ENST00000378605.3_Silent_p.R303R|BEND7_ENST00000396898.2_Silent_p.R355R	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	342	BEN.						protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						CTAGTCCTTTCCGGTTGTCAT	0.423000													25	109					0	0	1	0	0
COX5A	9377	broad.mit.edu	37	15	75219166	75219166	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr15:75219166G>A	ENST00000322347.6	-	3	433	c.280C>T	c.(280-282)Cgg>Tgg	p.R94W	COX5A_ENST00000568517.1_Missense_Mutation_p.R13W|COX5A_ENST00000567270.1_Missense_Mutation_p.R55W|COX5A_ENST00000568783.1_Missense_Mutation_p.R94W|COX5A_ENST00000564811.1_Missense_Mutation_p.R94W|COX5A_ENST00000562233.1_Intron	NM_004255.3	NP_004246.2	P20674	COX5A_HUMAN	cytochrome c oxidase subunit Va	94					respiratory electron transport chain	mitochondrial inner membrane	cytochrome-c oxidase activity|electron carrier activity|metal ion binding			endometrium(1)|large_intestine(1)|pancreas(1)	3						CTGCATGCCCGCAAAGCAGCA	0.388000													5	111					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19284199	19284199	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:19284199G>A	ENST00000308406.5	+	4	1063	c.677G>A	c.(676-678)tGg>tAg	p.W226*	MAPK7_ENST00000395602.4_Nonsense_Mutation_p.W226*|MAPK7_ENST00000571657.1_Intron|MAPK7_ENST00000395604.3_Nonsense_Mutation_p.W226*|MAPK7_ENST00000299612.7_Nonsense_Mutation_p.W87*	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	226	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					GCCACGCGCTGGTACCGTGCG	0.562000													6	49					0	0	1	0	0
CYP3A43	64816	broad.mit.edu	37	7	99461158	99461158	+	Splice_Site	SNP	A	A	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr7:99461158A>G	ENST00000354829.2	+	12	1356		c.e12-1		CYP3A43_ENST00000415413.1_Splice_Site|CYP3A43_ENST00000444905.1_Intron|CYP3A43_ENST00000222382.5_Splice_Site_p.R419_splice|CYP3A43_ENST00000477658.1_Intron|CYP3A43_ENST00000417625.1_Splice_Site|CYP3A43_ENST00000342499.4_Intron|CYP3A43_ENST00000312017.5_Intron	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	CTGTGAAAGTAGGTTCAGTAA	0.413000													23	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179456494	179456494	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:179456494C>T	ENST00000589042.1	-	303	60276	c.60052G>A	c.(60052-60054)Gaa>Aaa	p.E20018K	TTN_ENST00000342175.6_Missense_Mutation_p.E11145K|TTN_ENST00000460472.2_Missense_Mutation_p.E10953K|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E11078K|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E18377K|TTN_ENST00000342992.6_Missense_Mutation_p.E17450K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18377							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGCCTTCTTCTTGATATTCT	0.423000													52	51					0	0	1	0	0
SLC35D3	340146	broad.mit.edu	37	6	137243766	137243766	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:137243766T>C	ENST00000331858.4	+	1	365	c.200T>C	c.(199-201)gTg>gCg	p.V67A		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	67					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		CTCATCGCCGTGCCCCCCTTC	0.716000													4	14					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123383038	123383038	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:123383038G>A	ENST00000360772.3	-	24	4277	c.3899C>T	c.(3898-3900)gCg>gTg	p.A1300V	MYLK_ENST00000360304.3_Missense_Mutation_p.A1300V|MYLK_ENST00000359169.1_Missense_Mutation_p.A1300V|MYLK_ENST00000354792.5_Missense_Mutation_p.A100V|MYLK_ENST00000346322.5_Missense_Mutation_p.A1231V|MYLK_ENST00000475616.1_Missense_Mutation_p.A1300V			Q15746	MYLK_HUMAN	myosin light chain kinase	1300	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.			A -> G (in Ref. 1; CAA59685).	aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CTCCTGGCGCGCGGCCAGGAT	0.632000													81	112					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64521044	64521044	+	Silent	SNP	C	C	T			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr11:64521044C>T	ENST00000164139.3	-	11	1748	c.1350G>A	c.(1348-1350)tcG>tcA	p.S450S	PYGM_ENST00000377432.3_Silent_p.S362S	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	450					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TGACGGCGTGCGACCCCGCGA	0.662000													3	11					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10247330	10247330	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:10247330T>C	ENST00000418404.3	-	15	1844	c.1681A>G	c.(1681-1683)Aaa>Gaa	p.K561E	MYH13_ENST00000252172.4_Missense_Mutation_p.K561E|MYH13_ENST00000570743.1_Missense_Mutation_p.K561E			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	561	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TTGTTGGATTTTCCAAGATGC	0.547000													123	51					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186041	128186041	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr2:128186041T>G	ENST00000453608.2	+	8	1078	c.1070T>G	c.(1069-1071)cTg>cGg	p.L357R	PROC_ENST00000409048.1_Missense_Mutation_p.L336R|PROC_ENST00000422777.3_Missense_Mutation_p.L302R|PROC_ENST00000234071.3_Missense_Mutation_p.L302R			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	302	Peptidase S1.				blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	GACATCGCACTGCTGCACCTG	0.647000													14	54					0	0	1	0	0
ENPP3	5169	broad.mit.edu	37	6	132006597	132006597	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr6:132006597G>A	ENST00000414305.1	+	14	1542	c.1214G>A	c.(1213-1215)cGc>cAc	p.R405H	ENPP3_ENST00000358229.5_Missense_Mutation_p.R405H|ENPP3_ENST00000357639.3_Missense_Mutation_p.R405H			O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 3	405	Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity	p.R405L(1)		NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CCTGCCCCCCGCATCCGAGCT	0.378000													4	125					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123368043	123368044	+	Splice_Site	INS	-	-	G	rs138786404		TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr3:123368043_123368044insG	ENST00000360772.3	-	26	4667		c.e26-2		MYLK_ENST00000475616.1_Splice_Site|MYLK_ENST00000360304.3_Splice_Site|MYLK_ENST00000359169.1_Splice_Site|MYLK_ENST00000354792.5_Splice_Site|MYLK_ENST00000346322.5_Splice_Site			Q15746	MYLK_HUMAN	myosin light chain kinase						aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTTCGGCTCTGGGGGGGGCAC	0.624													8	108	---	---	---	---					
RP11-19N8.4	0	broad.mit.edu	37	16	33070154	33070154	+	RNA	DEL	C	C	-			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr16:33070154delC	ENST00000561541.1	-	0	291																											CCTATCACATCCCATTCCAGC	0.488													5	5	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578231	7578245	+	In_Frame_Del	DEL	CAAATACTCCACACG	CAAATACTCCACACG	-	rs142813240		TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:7578231_7578245delCAAATACTCCACACG	ENST00000420246.2	-	6	736_750	c.604_618delCGTGTGGAGTATTTG	c.(604-618)del	p.RVEYL202del	TP53_ENST00000269305.4_In_Frame_Del_p.RVEYL202del|TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_In_Frame_Del_p.RVEYL202del|TP53_ENST00000455263.2_In_Frame_Del_p.RVEYL202del|TP53_ENST00000413465.2_In_Frame_Del_p.RVEYL202del|TP53_ENST00000445888.2_In_Frame_Del_p.RVEYL202del	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	202	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		LR -> FC (in a sporadic cancer; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(68)|p.E204*(33)|p.Y205S(14)|p.Y205D(13)|p.Y205F(8)|p.Y205N(8)|p.0?(8)|p.L206*(7)|p.V203E(6)|p.R202S(6)|p.Y205H(5)|p.Y73C(5)|p.?(5)|p.Y112C(5)|p.R202H(4)|p.L206fs*41(4)|p.R202C(4)|p.R202P(4)|p.E204D(4)|p.Y205*(4)|p.E111*(3)|p.V203fs*44(3)|p.V203L(3)|p.V203V(3)|p.R202L(3)|p.E204fs*5(3)|p.E72*(3)|p.V203M(2)|p.E204G(2)|p.Y73N(2)|p.Y112N(2)|p.E204fs*43(2)|p.E204E(2)|p.E204K(2)|p.V203fs*6(2)|p.V203A(1)|p.Y205fs*42(1)|p.?fs(1)|p.P191fs*6(1)|p.E204fs*4(1)|p.E204fs*39(1)|p.E204_N210delEYLDDRN(1)|p.E72D(1)|p.R202G(1)|p.Y73S(1)|p.N200fs*4(1)|p.V203_E204>V*(1)|p.G199fs*42(1)|p.R202R(1)|p.Y205fs*43(1)|p.E204A(1)|p.L201_R202>FC(1)|p.R202fs*9(1)|p.R202fs*8(1)|p.V203_E204>LV(1)|p.R202fs*7(1)|p.Y112S(1)|p.L206F(1)|p.L206L(1)|p.E111D(1)|p.E204V(1)|p.E204Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTGTCATCCAAATACTCCACACGCAAATTTCCT	0.549		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	23	---	---	---	---					
KRT40	125115	broad.mit.edu	37	17	39140333	39140334	+	In_Frame_Ins	INS	-	-	AAAGTAGCATGGTTG			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr17:39140333_39140334insAAAGTAGCATGGTTG	ENST00000377755.4	-	1	226_227	c.192_193insCAACCATGCTACTTT	c.(190-195)ttctgg>ttCAACCATGCTACTTTctgg	p.63_64insFNHAT	KRT40_ENST00000398486.2_In_Frame_Ins_p.63_64insFNHAT			Q6A162	K1C40_HUMAN	keratin 40	63	Head.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				CAACTCCCAGTAAAGTAGCATG	0.545													11	180	---	---	---	---					
KCTD1	284252	broad.mit.edu	37	18	24128223	24128225	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chr18:24128223_24128225delTCC	ENST00000417602.1	-	1	275_277	c.276_278delGGA	c.(274-279)gaa>ga	p.EE94del	KCTD1_ENST00000408011.3_Intron|KCTD1_ENST00000317932.7_Intron|KCTD1_ENST00000579973.1_Intron	NM_001142730.2	NP_001136202.1	Q719H9	KCTD1_HUMAN	potassium channel tetramerization domain containing 1	0	BTB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(3)	12	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			ctcctcctcttcctcctcctcct	0.655													2	4	---	---	---	---					
HMGB3	3149	broad.mit.edu	37	X	150156315	150156316	+	Frame_Shift_Ins	INS	-	-	A			TCGA-UF-A7JK-01A-11D-A34J-08	TCGA-UF-A7JK-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c27adf9-c014-4362-a0e3-974f9522a393	938c2f93-5c8a-41fb-b2c4-3c501b059576	g.chrX:150156315_150156316insA	ENST00000325307.7	+	5	627_628	c.531_532insA	c.(529-534)cgaaaafs	p.RK177fs	HMGB3_ENST00000448905.2_Frame_Shift_Ins_p.RK177fs	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	177					DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding			endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					AAGTTGCCCGGAAAAaggtgga	0.446													50	24	---	---	---	---					
