Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RNASE2	6036	broad.mit.edu	37	14	21424254	21424254	+	Missense_Mutation	SNP	C	C	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr14:21424254C>G	ENST00000304625.2	+	2	414	c.324C>G	c.(322-324)atC>atG	p.I108M		NM_002934.2	NP_002925.1	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	108					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity	p.I108I(2)		breast(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	17	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)		TGCCTTTAATCCACTGTAACC	0.418000													24	102					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5086992	5086992	+	Missense_Mutation	SNP	T	T	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr17:5086992T>C	ENST00000399604.4	-	1	700	c.560A>G	c.(559-561)gAa>gGa	p.E187G	ZNF594_ENST00000575779.1_Missense_Mutation_p.E187G			Q96JF6	ZN594_HUMAN	zinc finger protein 594	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTTTCCACATTCATGACATAT	0.373000													16	131					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131826374	131826374	+	Missense_Mutation	SNP	G	G	A	rs150152490		TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr8:131826374G>A	ENST00000286355.5	-	14	4946	c.2854C>T	c.(2854-2856)Cgg>Tgg	p.R952W	ADCY8_ENST00000377928.3_Missense_Mutation_p.R821W	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	952					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AAGATATTCCGGAGCATGTTC	0.552000										HNSCC(32;0.087)			8	117					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61433915	61433915	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr2:61433915C>T	ENST00000398571.2	-	71	9102	c.9026G>A	c.(9025-9027)cGc>cAc	p.R3009H		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	3009					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			AAGATAAGGGCGTGTAGACTT	0.393000													7	77					0	0	1	0	0
LAPTM4A	9741	broad.mit.edu	37	2	20237127	20237127	+	Missense_Mutation	SNP	T	T	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr2:20237127T>C	ENST00000175091.4	-	4	889	c.382A>G	c.(382-384)Att>Gtt	p.I128V		NM_014713.4	NP_055528.1	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	128					transport	endomembrane system|Golgi apparatus|integral to membrane				endometrium(3)|kidney(1)|large_intestine(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAGAACTAATAGCAACCAGG	0.343000													10	69					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175899049	175899049	+	Silent	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:175899049G>A	ENST00000359240.3	+	5	3043	c.2373G>A	c.(2371-2373)acG>acA	p.T791T	ADAM29_ENST00000404450.4_Silent_p.T791T|RP13-577H12.2_ENST00000507525.1_RNA|ADAM29_ENST00000514159.1_Silent_p.T791T|ADAM29_ENST00000445694.1_Silent_p.T791T	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	791	9 X 9 AA approximate repeats.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.T791T(1)		NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CTCAGTTGACGCCTTCCCAGA	0.572000													17	160					0	0	1	0	0
KCTD20	222658	broad.mit.edu	37	6	36447401	36447401	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr6:36447401G>C	ENST00000373731.2	+	5	962	c.571G>C	c.(571-573)Gat>Cat	p.D191H	KCTD20_ENST00000449081.2_Intron|KCTD20_ENST00000544295.1_Intron|KCTD20_ENST00000474988.1_Intron|KCTD20_ENST00000536244.1_Missense_Mutation_p.D46H	NM_173562.3	NP_775833.2	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerization domain containing 20	191	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.D191H(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|skin(1)	15						CAATTGTCCTGATGGCATCTC	0.358000													10	133					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136170943	136170943	+	Missense_Mutation	SNP	T	T	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr3:136170943T>C	ENST00000383202.2	-	14	1616	c.1360A>G	c.(1360-1362)Agg>Ggg	p.R454G	STAG1_ENST00000434713.2_Missense_Mutation_p.R228G|STAG1_ENST00000536929.1_Missense_Mutation_p.R38G|STAG1_ENST00000236698.5_Missense_Mutation_p.R454G	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	454					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						CTTCCCCTCCTCTTTGCTAAT	0.373000													16	115					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891896	32891896	+	RNA	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:32891896G>C	ENST00000330048.5	-	0	2827					NR_003083.2																						TGGTCCCACTGTTGATGACAG	0.627000													9	70					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308964	248308964	+	Missense_Mutation	SNP	G	G	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:248308964G>T	ENST00000366476.1	+	1	515	c.515G>T	c.(514-516)cGg>cTg	p.R172L		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TGTGGGTCTCGGGAAATAGCC	0.428000													35	492					1.36161e-19	1.50426e-19	1	1	0
CLPS	1208	broad.mit.edu	37	6	35765036	35765036	+	Silent	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr6:35765036G>A	ENST00000259938.2	-	1	52	c.30C>T	c.(28-30)gtC>gtT	p.V10V		NM_001832.3	NP_001823.1	P04118	COL_HUMAN	colipase, pancreatic	10					lipid catabolic process|lipid digestion|retinoid metabolic process|steroid metabolic process	extracellular region				large_intestine(2)|lung(2)|prostate(1)	5						CAGAGAGGGCGACAAGCAGGA	0.607000													15	153					0	0	1	0	0
PPM1F	9647	broad.mit.edu	37	22	22277783	22277783	+	Silent	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr22:22277783C>T	ENST00000407142.1	-	6	1603	c.543G>A	c.(541-543)acG>acA	p.T181T	PPM1F_ENST00000263212.5_Silent_p.T349T|PPM1F_ENST00000538191.1_Silent_p.T245T			P49593	PPM1F_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1F	349					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	12	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		CCTCGGAGCCCGTCAGCGCCC	0.642000													8	70					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47746457	47746457	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr21:47746457C>T	ENST00000359568.5	+	2	328	c.221C>T	c.(220-222)tCa>tTa	p.S74L	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	74					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AAAAGCACATCATGTGACGAC	0.522000													13	120					0	0	1	0	0
KLF7	8609	broad.mit.edu	37	2	207988567	207988567	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr2:207988567G>C	ENST00000309446.6	-	2	1040	c.664C>G	c.(664-666)Cag>Gag	p.Q222E	KLF7_ENST00000412414.2_Missense_Mutation_p.Q194E|KLF7_ENST00000423015.1_Intron|KLF7_ENST00000467833.1_Intron|KLF7_ENST00000458272.1_Intron|KLF7_ENST00000421199.1_Missense_Mutation_p.Q189E	NM_003709.3	NP_003700.1	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	222					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(3)|liver(1)|lung(4)|skin(1)	11				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		CCGTTAAACTGACAGCGGTGA	0.557000													15	128					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349129	30349129	+	Missense_Mutation	SNP	C	C	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr17:30349129C>G	ENST00000327564.7	+	1	1106	c.1045C>G	c.(1045-1047)Cat>Gat	p.H349D	LRRC37B_ENST00000584368.1_Missense_Mutation_p.H334D|LRRC37B_ENST00000543378.2_Missense_Mutation_p.H240D|LRRC37B_ENST00000394713.3_Missense_Mutation_p.H322D|LRRC37B_ENST00000341671.7_Missense_Mutation_p.H322D			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	322						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TCCACTGAATCATGAAGTGAC	0.493000													11	183					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639024	6639024	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:6639024G>A	ENST00000333172.6	+	6	2099	c.1906G>A	c.(1906-1908)Gcc>Acc	p.A636T	TAS1R1_ENST00000351136.3_Missense_Mutation_p.A382T|TAS1R1_ENST00000328191.4_3'UTR	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	636					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GCTACGCCAGGCCCTCTTTGC	0.537000													14	131					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79917892	79917892	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr9:79917892G>C	ENST00000360280.3	+	34	4134	c.3874G>C	c.(3874-3876)Gag>Cag	p.E1292Q	VPS13A_ENST00000376636.3_Missense_Mutation_p.E1253Q|VPS13A_ENST00000357409.5_Missense_Mutation_p.E1292Q|VPS13A_ENST00000376634.4_Missense_Mutation_p.E1292Q|VPS13A_ENST00000423463.2_3'UTR	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	1292					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ATTAAATCTTGAGGTTGTGGT	0.353000													5	138					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18937327	18937327	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:18937327C>T	ENST00000446231.2	-	1	449	c.37G>A	c.(37-39)Ggc>Agc	p.G13S	SMG1_ENST00000389467.3_Missense_Mutation_p.G13S|SMG1_ENST00000567737.1_5'UTR			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	13	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ccgccgccgccgctgcTCAGC	0.736000													4	22					0	0	1	0	0
RNASE2	6036	broad.mit.edu	37	14	21424255	21424255	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr14:21424255C>T	ENST00000304625.2	+	2	415	c.325C>T	c.(325-327)Cac>Tac	p.H109Y		NM_002934.2	NP_002925.1	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	109					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	17	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)		GCCTTTAATCCACTGTAACCT	0.418000													25	101					0	0	1	0	0
TNFSF4	7292	broad.mit.edu	37	1	173176258	173176258	+	Missense_Mutation	SNP	C	C	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:173176258C>G	ENST00000281834.3	-	1	194	c.58G>C	c.(58-60)Gag>Cag	p.E20Q		NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	20					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						TTGTTCCTCTCGAATCTTGGC	0.512000													4	85					0	0	1	0	0
ALDH3A2	224	broad.mit.edu	37	17	19578919	19578919	+	Missense_Mutation	SNP	C	C	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr17:19578919C>A	ENST00000571163.1	+	3	275	c.275C>A	c.(274-276)aCt>aAt	p.T92N	ALDH3A2_ENST00000579855.1_3'UTR|ALDH3A2_ENST00000176643.6_3'UTR|ALDH3A2_ENST00000574597.1_3'UTR|ALDH3A2_ENST00000395575.2_3'UTR|ALDH3A2_ENST00000339618.4_3'UTR|ALDH3A2_ENST00000581518.1_3'UTR			P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3 family, member A2	0					cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|ovary(2)|prostate(1)	13	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	AGTGCCTCTACTGAATTATTC	0.328000													22	118					2.37509e-13	2.59916e-13	1	1	0
GAN	8139	broad.mit.edu	37	16	81396185	81396185	+	Missense_Mutation	SNP	A	A	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:81396185A>G	ENST00000248272.3	+	6	1217	c.1055A>G	c.(1054-1056)aAt>aGt	p.N352S		NM_022041.3	NP_071324.1	Q9H2C0	GAN_HUMAN	gigaxonin	352					cell death	cytoplasm|neurofilament	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)	25		Colorectal(91;0.153)				CCAGATGCAAATACATGGACA	0.403000													16	88					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37627938	37627938	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr17:37627938C>T	ENST00000447079.4	+	2	1886	c.1853C>T	c.(1852-1854)gCt>gTt	p.A618V	CDK12_ENST00000430627.2_Missense_Mutation_p.A618V	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	618					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						GTAACAGCTGCTATTCCACAC	0.478000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			12	168					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66467860	66467860	+	Missense_Mutation	SNP	A	A	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:66467860A>C	ENST00000273854.3	-	3	1009	c.409T>G	c.(409-411)Tgc>Ggc	p.C137G	EPHA5_ENST00000354839.4_Missense_Mutation_p.C137G|EPHA5_ENST00000432638.2_Missense_Mutation_p.C137G|EPHA5_ENST00000511294.1_Missense_Mutation_p.C137G	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	137					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						AGGCTGTTGCAGTCCCGCAGG	0.428000										TSP Lung(17;0.13)			12	132					0	0	1	0	0
RPA2	6118	broad.mit.edu	37	1	28233480	28233480	+	Missense_Mutation	SNP	T	T	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:28233480T>C	ENST00000373912.3	-	4	591	c.292A>G	c.(292-294)Aca>Gca	p.T98A	RPA2_ENST00000373909.3_Missense_Mutation_p.T106A|RPA2_ENST00000313433.7_Missense_Mutation_p.T186A	NM_002946.3	NP_002937.1	P15927	RFA2_HUMAN	replication protein A2, 32kDa	98	Asp/Glu-rich (acidic).				cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|regulation of double-strand break repair via homologous recombination|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor A complex|PML body	protein phosphatase binding|single-stranded DNA binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(3)|skin(1)	11		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.62e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00294)|STAD - Stomach adenocarcinoma(196;0.00308)|BRCA - Breast invasive adenocarcinoma(304;0.00613)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGCAGCTGTCATGTCATCT	0.423000								Direct reversal of damage;Nucleotide excision repair (NER)					12	65					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25438318	25438318	+	RNA	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr15:25438318G>A	ENST00000424208.1	+	0	1177				SNHG14_ENST00000414175.1_RNA	NR_003305.1																						GGTCCCAATGGTCCCAGGCCA	0.582000													4	55					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240256629	240256629	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:240256629G>A	ENST00000319653.9	+	1	1450	c.1220G>A	c.(1219-1221)tGt>tAt	p.C407Y		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	407					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGCCAGCGCTGTTTCAAGCCC	0.692000													7	58					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587485	36587485	+	Missense_Mutation	SNP	A	A	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr22:36587485A>G	ENST00000332987.1	-	7	1104	c.682T>C	c.(682-684)Ttt>Ctt	p.F228L	APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000352371.1_Missense_Mutation_p.F231L|APOL4_ENST00000404685.3_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	232					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						TCAAGTGCAAAAGAAAGCACA	0.483000													4	73					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906812	164906812	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr3:164906812G>A	ENST00000475390.1	-	2	2250	c.1807C>T	c.(1807-1809)Cgc>Tgc	p.R603C	SLITRK3_ENST00000241274.3_Missense_Mutation_p.R603C			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	603	LRRCT 2.					integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TCAATAGTGCGCACATCACGG	0.552000										HNSCC(40;0.11)			4	83					0	0	1	0	0
KXD1	79036	broad.mit.edu	37	19	18672916	18672916	+	Missense_Mutation	SNP	G	G	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:18672916G>T	ENST00000602094.1	+	2	1510	c.50G>T	c.(49-51)aGc>aTc	p.S17I	KXD1_ENST00000599319.1_Missense_Mutation_p.S17I|KXD1_ENST00000599000.1_Missense_Mutation_p.S17I|KXD1_ENST00000598830.1_Missense_Mutation_p.S17I|KXD1_ENST00000539106.1_Missense_Mutation_p.S17I|KXD1_ENST00000222307.4_Missense_Mutation_p.S17I|KXD1_ENST00000595073.1_Missense_Mutation_p.S17I|KXD1_ENST00000540691.1_Missense_Mutation_p.S17I|KXD1_ENST00000601630.1_Missense_Mutation_p.S17I			Q9BQD3	CS050_HUMAN	KxDL motif containing 1	17							protein binding										CGCATCCTGAGCATGGTGAAC	0.597000													3	30					0.00909568	0.00917477	1	1	0
COL11A1	1301	broad.mit.edu	37	1	103455097	103455097	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:103455097C>T	ENST00000358392.2	-	29	2724	c.2407G>A	c.(2407-2409)Gac>Aac	p.D803N	COL11A1_ENST00000512756.1_Missense_Mutation_p.D675N|COL11A1_ENST00000370096.3_Missense_Mutation_p.D791N|COL11A1_ENST00000353414.4_Missense_Mutation_p.D752N	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	791	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGACCCATGTCACCTTTGAAT	0.289000													4	81					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106431395	106431395	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr8:106431395G>C	ENST00000407775.2	+	2	314	c.64G>C	c.(64-66)Gat>Cat	p.D22H	ZFPM2_ENST00000520492.1_5'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	22					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGCCATTGAAGATGAGGAAGA	0.398000													4	83					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14417427	14417427	+	RNA	SNP	A	A	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr21:14417427A>G	ENST00000507941.1	+	0	95																											AAGGTATTCAATTCAGCTGAG	0.343000													3	22					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47527697	47527697	+	Silent	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr18:47527697G>A	ENST00000285039.7	-	5	839	c.540C>T	c.(538-540)ttC>ttT	p.F180F		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	180	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CAACGGTGGCGAAATAGCGCA	0.532000													5	145					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561642	32561642	+	Silent	SNP	T	T	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr14:32561642T>C	ENST00000345122.3	+	2	2082	c.1767T>C	c.(1765-1767)gaT>gaC	p.D589D	ARHGAP5_ENST00000432921.1_Silent_p.D589D|ARHGAP5_ENST00000539826.2_Silent_p.D589D|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000556611.1_Silent_p.D589D	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	589					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TATATCACGATAGTACCAATA	0.378000													11	94					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8693383	8693383	+	Missense_Mutation	SNP	G	G	C	rs144112080	byFrequency	TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr12:8693383G>C	ENST00000299663.3	-	1	176	c.11C>G	c.(10-12)tCt>tGt	p.S4C	CLEC4E_ENST00000446457.2_Missense_Mutation_p.S4C|CLEC4E_ENST00000545274.1_Missense_Mutation_p.S4C	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	4						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					AGATGATTTAGATGAATTCAT	0.368000													13	151					0	0	1	0	0
ZC3H10	84872	broad.mit.edu	37	12	56514873	56514873	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr12:56514873G>A	ENST00000257940.2	+	3	803	c.527G>A	c.(526-528)gGc>gAc	p.G176D	RP11-603J24.5_ENST00000549438.1_RNA|RP11-603J24.5_ENST00000550947.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	176	Poly-Gly.						nucleic acid binding|zinc ion binding			breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			ACTGGTGGGGGCTCAACAGGC	0.552000													4	101					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42437787	42437787	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr15:42437787C>T	ENST00000397272.3	-	16	1863	c.1772G>A	c.(1771-1773)aGt>aAt	p.S591N	PLA2G4F_ENST00000382396.4_Missense_Mutation_p.S589N	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	589	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GATATTCACACTGCCTCTGTA	0.597000													15	200					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107114812	107114812	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr7:107114812C>T	ENST00000304402.4	+	3	1650	c.307C>T	c.(307-309)Ctt>Ttt	p.L103F	COG5_ENST00000297135.3_Intron|COG5_ENST00000475638.2_Intron|COG5_ENST00000393603.2_Intron|COG5_ENST00000347053.3_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	103						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						TATAGTTATCCTTCTGCTTTC	0.358000													6	158					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93682201	93682201	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:93682201G>C	ENST00000343253.7	+	13	2227	c.1725G>C	c.(1723-1725)aaG>aaC	p.K575N	CCDC18_ENST00000557479.1_Missense_Mutation_p.K694N|CCDC18_ENST00000334652.5_5'UTR|CCDC18_ENST00000338949.4_Missense_Mutation_p.K375N|CCDC18_ENST00000401026.3_Missense_Mutation_p.K576N			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	575										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AGATGACAAAGAAATGTTCTC	0.313000													7	118					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123516408	123516408	+	Missense_Mutation	SNP	C	C	T	rs147803210		TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr11:123516408C>T	ENST00000392770.2	-	2	908	c.106G>A	c.(106-108)Gtg>Atg	p.V36M	SCN3B_ENST00000530277.1_Missense_Mutation_p.V36M|SCN3B_ENST00000299333.3_Missense_Mutation_p.V36M	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	36	Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		TTGCCCTGCACGGCCTCCGTC	0.627000													17	126					0	0	1	0	0
FBXL5	26234	broad.mit.edu	37	4	15627482	15627482	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:15627482G>C	ENST00000341285.3	-	9	1367	c.1243C>G	c.(1243-1245)Caa>Gaa	p.Q415E	FBXL5_ENST00000382358.4_Missense_Mutation_p.Q289E|FBXL5_ENST00000412094.2_Missense_Mutation_p.Q398E	NM_001193534.1|NM_001193535.1|NM_012161.3	NP_001180463.1|NP_001180464.1|NP_036293.1	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5	415					iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13						AAGCCACTTTGATGAGATGTC	0.423000													12	136					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308207	140308207	+	Missense_Mutation	SNP	G	G	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr5:140308207G>T	ENST00000253807.2	+	1	1730	c.1730G>T	c.(1729-1731)gGa>gTa	p.G577V	PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.G577V|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAGGACTGGACACTTGGTC	0.493000													20	158					4.35082e-09	4.6731e-09	1	1	0
NOM1	64434	broad.mit.edu	37	7	156743149	156743149	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr7:156743149G>A	ENST00000275820.3	+	1	733	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K		NM_138400.1	NP_612409.1	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	240	Glu-rich.|Necessary for nucleolar localization and for targeting PPP1CA to the nucleolus.				RNA metabolic process	nucleolus	protein binding	p.E240*(1)		endometrium(5)|kidney(4)|large_intestine(9)|lung(7)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		TGAGGAGGAGGAAGATGCCGG	0.552000													6	122					0	0	1	0	0
DCLK2	166614	broad.mit.edu	37	4	151124979	151124979	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:151124979C>T	ENST00000296550.7	+	5	1748	c.994C>T	c.(994-996)Cct>Tct	p.P332S	DCLK2_ENST00000302176.8_Missense_Mutation_p.P349S|DCLK2_ENST00000506325.1_Missense_Mutation_p.P332S	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	332	Ser-rich.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					ACTTTCTACTCCTAAATCTAC	0.403000													15	135					0	0	1	0	0
LPAR2	9170	broad.mit.edu	37	19	19737971	19737971	+	Silent	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:19737971G>C	ENST00000542587.1	-	5	1025	c.123C>G	c.(121-123)acC>acG	p.T41T	LPAR2_ENST00000407877.3_Silent_p.T41T|LPAR2_ENST00000586703.1_Silent_p.T41T			Q9HBW0	LPAR2_HUMAN	lysophosphatidic acid receptor 2	41					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	cell surface|integral to plasma membrane	LIM domain binding|lipid binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	10						GCACGCTGACGGTCAGCCCCA	0.592000													5	52					0	0	1	0	0
LCOR	84458	broad.mit.edu	37	10	98711951	98711951	+	Silent	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr10:98711951C>T	ENST00000540664.1	+	7	873	c.330C>T	c.(328-330)aaC>aaT	p.N110N	LCOR_ENST00000498444.1_3'UTR|LCOR_ENST00000371097.4_Silent_p.N110N|LCOR_ENST00000356016.3_Silent_p.N110N|LCOR_ENST00000371103.3_Silent_p.N110N	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CTCAAGGGAACGGGTAAGGGA	0.438000													5	76					0	0	1	0	0
RDH10	157506	broad.mit.edu	37	8	74235183	74235183	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr8:74235183G>A	ENST00000240285.5	+	6	1616	c.938G>A	c.(937-939)cGg>cAg	p.R313Q	RP11-434I12.2_ENST00000517475.1_RNA|RDH10_ENST00000519380.1_Missense_Mutation_p.R148Q|RP11-434I12.2_ENST00000514599.1_RNA	NM_172037.4	NP_742034.1	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10 (all-trans)	313					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)	11	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			TGCATGTATCGGTTCCTAGGA	0.403000													8	106					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67980419	67980419	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:67980419G>A	ENST00000422611.2	-	17	2404	c.2365C>T	c.(2365-2367)Cgg>Tgg	p.R789W	SLC12A4_ENST00000338335.3_Intron|SLC12A4_ENST00000576616.1_Missense_Mutation_p.R787W|SLC12A4_ENST00000541864.2_Missense_Mutation_p.R756W|SLC12A4_ENST00000537830.2_Missense_Mutation_p.R781W|SLC12A4_ENST00000572037.1_Missense_Mutation_p.R739W|SLC12A4_ENST00000316341.3_Missense_Mutation_p.R787W	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	787					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GAGTTATGCCGCATGCCTCCC	0.652000													4	103					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142078760	142078760	+	Silent	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr3:142078760G>A	ENST00000264951.4	-	30	3525	c.3408C>T	c.(3406-3408)gcC>gcT	p.A1136A	XRN1_ENST00000392981.2_Silent_p.A1136A	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1136					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						ATAGTACATCGGCTTCTCTAT	0.313000													5	71					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70455336	70455336	+	Silent	SNP	A	A	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:70455336A>T	ENST00000503640.1	-	6	1393	c.1338T>A	c.(1336-1338)atT>atA	p.I446I	UGT2A1_ENST00000512704.1_Silent_p.I402I|UGT2A1_ENST00000514019.1_Silent_p.I612I|UGT2A2_ENST00000457664.2_Silent_p.I455I|UGT2A1_ENST00000502343.1_5'UTR|UGT2A1_ENST00000286604.4_Silent_p.I446I	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	446					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						GATCATGGTGAATTCTTGATA	0.393000													32	244					0	0	1	0	0
ALDOA	226	broad.mit.edu	37	16	30080251	30080251	+	Silent	SNP	C	C	T	rs11553120		TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:30080251C>T	ENST00000566897.1	+	8	1644	c.492C>T	c.(490-492)atC>atT	p.I164I	ALDOA_ENST00000564546.1_Silent_p.I164I|ALDOA_ENST00000564595.2_Silent_p.I218I|ALDOA_ENST00000338110.5_Silent_p.I164I|ALDOA_ENST00000412304.2_Silent_p.I164I|ALDOA_ENST00000395240.3_Silent_p.I164I|ALDOA_ENST00000569798.1_Silent_p.I164I|ALDOA_ENST00000563060.2_Silent_p.I164I|ALDOA_ENST00000569545.1_Silent_p.I164I|ALDOA_ENST00000395248.1_Silent_p.I218I			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	164					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						CCCTCGCCATCATGGAAAATG	0.562000											OREG0023729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	102					0	0	1	0	0
CENPQ	55166	broad.mit.edu	37	6	49448713	49448713	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr6:49448713G>A	ENST00000335783.3	+	6	491	c.397G>A	c.(397-399)Gat>Aat	p.D133N		NM_018132.3	NP_060602.2	Q7L2Z9	CENPQ_HUMAN	centromere protein Q	133					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(4)|ovary(2)|prostate(1)	11	Lung NSC(77;0.0128)					AAAGATGGAAGATTTAACTAA	0.323000													13	105					0	0	1	0	0
PRKCH	5583	broad.mit.edu	37	14	61915942	61915942	+	Missense_Mutation	SNP	A	A	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr14:61915942A>G	ENST00000332981.5	+	5	1059	c.674A>G	c.(673-675)cAa>cGa	p.Q225R	PRKCH_ENST00000555082.1_Missense_Mutation_p.Q64R	NM_006255.3	NP_006246.2	P24723	KPCL_HUMAN	protein kinase C, eta	225					intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		TGTACTTGCCAAAACAATATT	0.408000													9	91					0	0	1	0	0
G6PD	2539	broad.mit.edu	37	X	153762677	153762677	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chrX:153762677C>T	ENST00000393562.2	-	6	993	c.610G>A	c.(610-612)Ggg>Agg	p.G204R	G6PD_ENST00000393564.2_Missense_Mutation_p.G174R|G6PD_ENST00000369620.2_Missense_Mutation_p.G174R	NM_000402.3	NP_000393.4	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase	174					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(3)|ovary(4)	18	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGTCCCTCCCGAAGGGCTTC	0.617000													14	44					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	137056200	137056200	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr5:137056200G>A	ENST00000309755.4	-	2	531	c.88C>T	c.(88-90)Cct>Tct	p.P30S	KLHL3_ENST00000394937.3_Missense_Mutation_p.P30S|KLHL3_ENST00000508657.1_5'UTR	NM_017415.2	NP_059111.2	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	30						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		ATGTGGGCAGGGTTGACAGTG	0.507000													7	89					0	0	1	0	0
NECAB2	54550	broad.mit.edu	37	16	84027968	84027968	+	Missense_Mutation	SNP	G	G	T	rs146128471	byFrequency	TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:84027968G>T	ENST00000565691.1	+	5	1131	c.409G>T	c.(409-411)Gcc>Tcc	p.A137S	NECAB2_ENST00000305202.4_Missense_Mutation_p.A220S|NECAB2_ENST00000567703.1_3'UTR			Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	220					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						CCCCACTCCCGCCTCTGCCCC	0.612000													15	38					1.33834e-09	1.45091e-09	1	1	0
TTLL3	26140	broad.mit.edu	37	3	9868709	9868709	+	Missense_Mutation	SNP	G	G	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr3:9868709G>T	ENST00000383827.1	+	3	2548	c.267G>T	c.(265-267)gaG>gaT	p.E89D	TTLL3_ENST00000430793.1_Missense_Mutation_p.E89D|TTLL3_ENST00000427853.3_Missense_Mutation_p.E89D|TTLL3_ENST00000426895.4_Missense_Mutation_p.E444D|TTLL3_ENST00000397241.1_Missense_Mutation_p.E89D|TTLL3_ENST00000547186.1_Missense_Mutation_p.E301D|ARPC4-TTLL3_ENST00000397256.1_Missense_Mutation_p.E362D|TTLL3_ENST00000466245.1_3'UTR|TTLL3_ENST00000455274.1_Missense_Mutation_p.E89D			Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	301					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	Medulloblastoma(99;0.227)					ACCTGGAGGAGATGCTGAAGC	0.587000													4	104					0.00909568	0.00917477	1	1	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	71					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19749229	19749229	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:19749229C>T	ENST00000203556.4	-	8	737	c.600G>A	c.(598-600)atG>atA	p.M200I	GMIP_ENST00000587238.1_Missense_Mutation_p.M200I|GMIP_ENST00000445806.2_Missense_Mutation_p.M200I	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	200					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TCTGCTCCTTCATCCACTGCT	0.597000													4	42					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52469713	52469713	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr3:52469713C>T	ENST00000231721.2	-	16	2254	c.2255G>A	c.(2254-2256)gGc>gAc	p.G752D		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	752					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CCAGCTCTTGCCCCTGGCCTG	0.677000													4	72					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56814876	56814876	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr12:56814876G>C	ENST00000229201.4	-	24	3062	c.2908C>G	c.(2908-2910)Ctg>Gtg	p.L970V	TIMELESS_ENST00000553532.1_Missense_Mutation_p.L971V|TIMELESS_ENST00000554616.1_Missense_Mutation_p.L468V	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	971					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TCTTCTTCCAGATCTTCCTGG	0.473000													11	108					0	0	1	0	0
ARNT	405	broad.mit.edu	37	1	150808764	150808764	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:150808764G>A	ENST00000358595.5	-	7	892	c.692C>T	c.(691-693)gCc>gTc	p.A231V	ARNT_ENST00000515192.1_Missense_Mutation_p.A222V|ARNT_ENST00000505755.1_Missense_Mutation_p.A216V|ARNT_ENST00000468970.1_5'UTR|ARNT_ENST00000354396.2_Missense_Mutation_p.A231V	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	231	PAS 1.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACCTGTCAGGGCATTTTCTGA	0.418000			T	ETV6	AML								4	97					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143799	56143799	+	Nonsense_Mutation	SNP	A	A	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr11:56143799A>T	ENST00000302270.1	+	1	700	c.700A>T	c.(700-702)Aga>Tga	p.R234*		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					AGCTGAGGGAAGACAGAAGGC	0.473000													4	121					0	0	1	0	0
QDPR	5860	broad.mit.edu	37	4	17513674	17513674	+	Missense_Mutation	SNP	C	C	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:17513674C>A	ENST00000281243.5	-	1	183	c.4G>T	c.(4-6)Gcg>Tcg	p.A2S	QDPR_ENST00000508623.1_Missense_Mutation_p.A2S|QDPR_ENST00000513615.1_Missense_Mutation_p.A2S|QDPR_ENST00000428702.2_Missense_Mutation_p.A2S	NM_000320.2	NP_000311.2	P09417	DHPR_HUMAN	quinoid dihydropteridine reductase	2					dihydrobiopterin metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process	cytosol	6,7-dihydropteridine reductase activity|binding|electron carrier activity			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	13					NADH(DB00157)	GCCGCCGCCGCCATCCTGCTC	0.766000													5	26					1.23904e-05	1.31861e-05	1	1	0
ATAT1	79969	broad.mit.edu	37	6	30595812	30595812	+	Missense_Mutation	SNP	G	G	A	rs17852297		TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr6:30595812G>A	ENST00000376483.4	+	5	335	c.325G>A	c.(325-327)Gat>Aat	p.D109N	ATAT1_ENST00000329992.8_Missense_Mutation_p.D109N|ATAT1_ENST00000330083.5_Missense_Mutation_p.D97N|ATAT1_ENST00000318999.7_Missense_Mutation_p.D109N|ATAT1_ENST00000376478.2_Missense_Mutation_p.D109N|ATAT1_ENST00000319027.5_Missense_Mutation_p.D109N|ATAT1_ENST00000468713.1_3'UTR|ATAT1_ENST00000376485.4_Missense_Mutation_p.D109N			Q5SQI0	ATAT_HUMAN	alpha tubulin acetyltransferase 1	109							tubulin N-acetyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	9						CTCTTAGGATGATCGTGAGGC	0.468000													7	83					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59728263	59728263	+	Silent	SNP	G	G	A	rs111551773		TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr8:59728263G>A	ENST00000361421.1	-	7	1246	c.1026C>T	c.(1024-1026)gaC>gaT	p.D342D		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	342						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				ATGTCTTCACGTCAACAGGTT	0.493000													10	62					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165551851	165551851	+	Missense_Mutation	SNP	T	T	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr2:165551851T>A	ENST00000375458.2	-	11	2272	c.2051A>T	c.(2050-2052)gAt>gTt	p.D684V	COBLL1_ENST00000392717.2_Missense_Mutation_p.D760V|COBLL1_ENST00000342193.4_Missense_Mutation_p.D722V|COBLL1_ENST00000194871.6_Missense_Mutation_p.D789V|COBLL1_ENST00000409184.3_Missense_Mutation_p.D722V	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	760										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						AGGCAAAAGATCATCATTACC	0.393000													25	153					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62758432	62758432	+	Silent	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:62758432G>A	ENST00000512091.1	+	9	2082	c.1335G>A	c.(1333-1335)cgG>cgA	p.R445R	LPHN3_ENST00000507164.1_Silent_p.R513R|LPHN3_ENST00000514996.1_Silent_p.R445R|LPHN3_ENST00000507625.1_Silent_p.R513R|LPHN3_ENST00000506720.1_Silent_p.R513R|LPHN3_ENST00000514591.1_Silent_p.R445R|LPHN3_ENST00000508693.1_Silent_p.R513R|LPHN3_ENST00000545650.1_Silent_p.R445R|LPHN3_ENST00000511324.1_Silent_p.R513R|LPHN3_ENST00000506700.1_Silent_p.R445R|LPHN3_ENST00000504896.1_Silent_p.R445R|LPHN3_ENST00000506746.1_Silent_p.R513R|LPHN3_ENST00000508946.1_Silent_p.R445R|LPHN3_ENST00000509896.1_Silent_p.R513R|LPHN3_ENST00000514157.1_Silent_p.R445R			Q9HAR2	LPHN3_HUMAN	latrophilin 3	445					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CCACCCTTCGGACCACAACTT	0.483000													5	103					0	0	1	0	0
NFU1	27247	broad.mit.edu	37	2	69627666	69627666	+	Missense_Mutation	SNP	T	T	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr2:69627666T>C	ENST00000410022.2	-	7	755	c.550A>G	c.(550-552)Act>Gct	p.T184A	NFU1_ENST00000471185.1_Intron|NFU1_ENST00000303698.3_Missense_Mutation_p.T160A|NFU1_ENST00000394305.1_Missense_Mutation_p.T43A|NFU1_ENST00000462320.1_Missense_Mutation_p.T43A	NM_001002755.2	NP_001002755.1	Q9UMS0	NFU1_HUMAN	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	184	NifU.				iron-sulfur cluster assembly	cytosol|mitochondrion|nucleus	4 iron, 4 sulfur cluster binding|iron ion binding|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	7						TCCTGCACAGTTGGCCTGTGA	0.358000													12	191					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36179604	36179604	+	Missense_Mutation	SNP	T	T	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:36179604T>C	ENST00000303965.4	-	9	2191	c.1702A>G	c.(1702-1704)Ata>Gta	p.I568V		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	568	PH 1.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTTAATAGTATGCTGATCCAG	0.378000													11	96					0	0	1	0	0
GIPC3	126326	broad.mit.edu	37	19	3586578	3586578	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:3586578C>T	ENST00000322315.5	+	2	356	c.311C>T	c.(310-312)gCc>gTc	p.A104V		NM_133261.2	NP_573568.1	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	104										breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCATCTTTGCCCACGTGCGA	0.572000											OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	195					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73752808	73752808	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr17:73752808C>T	ENST00000200181.3	+	37	5108	c.4921C>T	c.(4921-4923)Ccc>Tcc	p.P1641S	ITGB4_ENST00000449880.2_Missense_Mutation_p.P1624S|ITGB4_ENST00000339591.3_Missense_Mutation_p.P1624S|ITGB4_ENST00000450894.3_Missense_Mutation_p.P1571S|ITGB4_ENST00000579662.1_Missense_Mutation_p.P1571S|GALK1_ENST00000225614.2_Intron	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1641	Fibronectin type-III 4.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTTGAGCACTCCCAGTGCCCC	0.667000													4	90					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4163838	4163838	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:4163838C>T	ENST00000294016.3	-	2	2144	c.1606G>A	c.(1606-1608)Gca>Aca	p.A536T		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	536					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						AAGTATTTTGCGGTGGCCTCA	0.507000													5	189					0	0	1	0	0
EIF4A2	1974	broad.mit.edu	37	3	186505353	186505353	+	Missense_Mutation	SNP	C	C	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr3:186505353C>G	ENST00000323963.5	+	9	1043	c.979C>G	c.(979-981)Ctg>Gtg	p.L327V	EIF4A2_ENST00000356531.5_Missense_Mutation_p.L232V|EIF4A2_ENST00000440191.2_Missense_Mutation_p.L328V			Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	327	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|urinary_tract(1)	28	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		AAGTCGTGTTCTGATCACTAC	0.393000			T	BCL6	NHL								24	212					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2924428	2924428	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr18:2924428G>C	ENST00000261596.4	-	15	2293	c.2055C>G	c.(2053-2055)atC>atG	p.I685M		NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	685	C-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CAGAAATGATGATCTTGTCAT	0.493000													15	125					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45294893	45294893	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:45294893G>A	ENST00000447098.2	-	10	1318	c.1307C>T	c.(1306-1308)gCg>gTg	p.A436V	PTCH2_ENST00000372192.3_Missense_Mutation_p.A436V	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	436	SSD.				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity	p.A436V(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					TGAGGCCACCGCCAGGGCCAC	0.672000									Basal Cell Nevus syndrome				4	52					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1733024	1733024	+	Silent	SNP	T	T	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:1733024T>A	ENST00000313288.4	+	6	1693	c.1587T>A	c.(1585-1587)gcT>gcA	p.A529A		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	529						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GAGACCCCGCTGAGGGTACGT	0.632000													7	90					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35804258	35804258	+	Missense_Mutation	SNP	C	C	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:35804258C>A	ENST00000392213.3	+	11	1941	c.1782C>A	c.(1780-1782)gaC>gaA	p.D594E	MAG_ENST00000361922.4_3'UTR|MAG_ENST00000537831.2_Missense_Mutation_p.D569E	NM_002361.3	NP_002352.1	P20916	MAG_HUMAN	myelin associated glycoprotein	594					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CAGAGCTGGACCTGAGCTATT	0.612000													11	70					0.000673444	0.000703779	1	1	0
KALRN	8997	broad.mit.edu	37	3	124053119	124053119	+	Missense_Mutation	SNP	A	A	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr3:124053119A>G	ENST00000360013.3	+	9	1545	c.1418A>G	c.(1417-1419)cAg>cGg	p.Q473R	KALRN_ENST00000460856.1_Missense_Mutation_p.Q473R|KALRN_ENST00000240874.3_Missense_Mutation_p.Q473R	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	473					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CAGGTCAGCCAGGATGGCAAA	0.562000													21	150					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99627983	99627983	+	Missense_Mutation	SNP	A	A	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr7:99627983A>T	ENST00000324306.6	+	5	1018	c.784A>T	c.(784-786)Agc>Tgc	p.S262C	ZKSCAN1_ENST00000535170.1_Missense_Mutation_p.S49C|ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.S226C	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	262	KRAB.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GAATTATGGGAGCGCATTTCC	0.498000													5	41					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12575076	12575076	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:12575076G>C	ENST00000397732.3	-	4	1831	c.1660C>G	c.(1660-1662)Cac>Gac	p.H554D	CTD-3105H18.18_ENST00000598753.1_Intron|ZNF709_ENST00000428311.1_Missense_Mutation_p.H554D	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						TCTCCAGTGTGAGTCCTTTCA	0.428000													16	267					0	0	1	0	0
ANKRD32	84250	broad.mit.edu	37	5	94014601	94014601	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr5:94014601G>C	ENST00000265140.5	+	15	2335	c.1916G>C	c.(1915-1917)aGa>aCa	p.R639T		NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	639										NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		AAGATGGGTAGAAATGTGATG	0.373000													6	109					0	0	1	0	0
CHD1L	9557	broad.mit.edu	37	1	146736116	146736116	+	Silent	SNP	T	T	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:146736116T>A	ENST00000369258.4	+	7	632	c.612T>A	c.(610-612)acT>acA	p.T204T	CHD1L_ENST00000431239.1_Silent_p.T204T|CHD1L_ENST00000369259.3_Intron|CHD1L_ENST00000361293.5_Intron|CHD1L_ENST00000467213.1_3'UTR	NM_001256336.1|NM_004284.4|NM_024568.2	NP_001243265.1|NP_004275.4|NP_078844.2	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein 1-like	204	Helicase ATP-binding.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(923;0.0487)					TGACCGGAACTCCCATCCAGA	0.428000													5	57					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121746944	121746944	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr2:121746944G>A	ENST00000452319.1	+	14	3514	c.3454G>A	c.(3454-3456)Ggc>Agc	p.G1152S	GLI2_ENST00000361492.4_Missense_Mutation_p.G1152S|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1152					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G1152S(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGTGAGCTCCGGCACCGTAGA	0.632000													7	41					0	0	1	0	0
C3P1	388503	broad.mit.edu	37	19	10158008	10158008	+	RNA	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:10158008G>A	ENST00000495140.1	+	0	1216																		p.S57S(1)		endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						TCTGTGTCTCGGACCCCTTTG	0.542000													16	215					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701757	56701757	+	Missense_Mutation	SNP	T	T	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:56701757T>G	ENST00000586855.2	-	5	1240	c.927A>C	c.(925-927)gaA>gaC	p.E309D	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.E309D			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	309					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CTTGAGGCTCTTCTTGGGAAA	0.547000													13	189					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72822728	72822728	+	Silent	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:72822728C>T	ENST00000268489.5	-	10	10119	c.9447G>A	c.(9445-9447)ccG>ccA	p.P3149P	ZFHX3_ENST00000397992.5_Silent_p.P2235P	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3149					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.P3149P(1)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CCATCAAGTTCGGCTTAGGAG	0.547000													10	173					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27742575	27742575	+	Silent	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:27742575G>C	ENST00000430629.2	-	5	656	c.441C>G	c.(439-441)ctC>ctG	p.L147L	WASF2_ENST00000536657.1_Silent_p.L147L	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	147					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TGTAGAATTTGAGTGCCTCTT	0.433000													25	120					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6296871	6296871	+	Silent	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:6296871C>T	ENST00000226760.1	+	7	986	c.816C>T	c.(814-816)gaC>gaT	p.D272D	WFS1_ENST00000503569.1_Silent_p.D272D	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	272					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		AAGATGATGACGAGCTGGCGG	0.607000													7	109					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807517	20807517	+	Missense_Mutation	SNP	A	A	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr19:20807517A>C	ENST00000601440.1	-	4	1312	c.1166T>G	c.(1165-1167)aTa>aGa	p.I389R	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						AGTATGAATTATCTTATGCGT	0.383000													5	134					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152083709	152083709	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:152083709C>T	ENST00000368804.1	-	2	1983	c.1984G>A	c.(1984-1986)Gag>Aag	p.E662K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	662	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCCTCCTCGCGCTTCAGC	0.667000													7	157					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143381872	143381872	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr8:143381872C>T	ENST00000519651.1	-	8	711	c.608G>A	c.(607-609)cGg>cAg	p.R203Q	TSNARE1_ENST00000520166.1_Missense_Mutation_p.R422Q|TSNARE1_ENST00000518928.1_5'UTR|TSNARE1_ENST00000307180.3_Missense_Mutation_p.R422Q|TSNARE1_ENST00000524325.1_Missense_Mutation_p.R421Q			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	422					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGCCTCCTCCCGCAGCCGGAT	0.632000													6	60					0	0	1	0	0
N4BP1	9683	broad.mit.edu	37	16	48595377	48595377	+	Missense_Mutation	SNP	C	C	G			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:48595377C>G	ENST00000262384.3	-	2	1413	c.1177G>C	c.(1177-1179)Gaa>Caa	p.E393Q	RP11-44I10.3_ENST00000563994.1_RNA	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	393					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				TCTCTGTCTTCTTGGAATCTT	0.358000													12	101					0	0	1	0	0
QDPR	5860	broad.mit.edu	37	4	17513673	17513673	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:17513673G>A	ENST00000281243.5	-	1	184	c.5C>T	c.(4-6)gCg>gTg	p.A2V	QDPR_ENST00000508623.1_Missense_Mutation_p.A2V|QDPR_ENST00000513615.1_Missense_Mutation_p.A2V|QDPR_ENST00000428702.2_Missense_Mutation_p.A2V	NM_000320.2	NP_000311.2	P09417	DHPR_HUMAN	quinoid dihydropteridine reductase	2					dihydrobiopterin metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process	cytosol	6,7-dihydropteridine reductase activity|binding|electron carrier activity			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	13					NADH(DB00157)	CGCCGCCGCCGCCATCCTGCT	0.766000													5	27					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154173460	154173460	+	Silent	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr5:154173460G>A	ENST00000336314.4	+	6	762	c.738G>A	c.(736-738)tcG>tcA	p.S246S		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	323							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATGAGACATCGAGTGTGAAGA	0.701000													19	124					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616785	248616785	+	Missense_Mutation	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:248616785G>A	ENST00000342927.3	+	1	709	c.687G>A	c.(685-687)atG>atA	p.M229I		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCCACAGGATGAACTCTGCTG	0.547000													7	101					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94839625	94839625	+	Missense_Mutation	SNP	T	T	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr5:94839625T>A	ENST00000358746.2	-	31	3408	c.3110A>T	c.(3109-3111)gAt>gTt	p.D1037V		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1037							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						GATAGCTTTATCATATTCACC	0.338000													10	132					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12294403	12294403	+	Missense_Mutation	SNP	C	C	T			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:12294403C>T	ENST00000358136.3	+	2	210	c.80C>T	c.(79-81)tCa>tTa	p.S27L	VPS13D_ENST00000356315.4_Missense_Mutation_p.S27L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	27					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GACCAGCTCTCAGTTGCACTT	0.393000													7	107					0	0	1	0	0
OR6S1	341799	broad.mit.edu	37	14	21109809	21109809	+	Silent	SNP	G	G	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr14:21109809G>A	ENST00000320704.3	-	1	41	c.42C>T	c.(40-42)ttC>ttT	p.F14F		NM_001001968.1	NP_001001968.1	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		CTGCCAGGACGAACTCTGTTG	0.453000													13	199					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228479702	228479702	+	Missense_Mutation	SNP	G	G	C			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr1:228479702G>C	ENST00000570156.2	+	44	11804	c.11730G>C	c.(11728-11730)tgG>tgC	p.W3910C	OBSCN_ENST00000359599.6_Missense_Mutation_p.W2328C|OBSCN_ENST00000366709.4_Missense_Mutation_p.W600C|OBSCN_ENST00000422127.1_Missense_Mutation_p.W3481C|OBSCN_ENST00000366707.4_Missense_Mutation_p.W600C|OBSCN_ENST00000284548.11_Missense_Mutation_p.W3481C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2948	Ig-like 40.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGTGGAGTGGAGGAAGGGGC	0.612000													7	114					0	0	1	0	0
LINC01250	101927554	broad.mit.edu	37	2	2910744	2910744	+	RNA	DEL	C	C	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr2:2910744delC	ENST00000457478.1	-	0	594																											cagccactcacccctacacct	0.692													4	6	---	---	---	---					
OTUD4	54726	broad.mit.edu	37	4	146077123	146077125	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr4:146077123_146077125delCAG	ENST00000454497.2	-	8	595_597	c.458_460delCTG	c.(457-462)gat>g	p.AD153del	OTUD4_ENST00000455611.2_5'UTR|OTUD4_ENST00000447906.2_In_Frame_Del_p.AD218del	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	218	OTU.						protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					CCATTCACATCAGCAGCAGCAGC	0.340													7	104	---	---	---	---					
PHAX	51808	broad.mit.edu	37	5	125939781	125939781	+	Frame_Shift_Del	DEL	A	A	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr5:125939781delA	ENST00000297540.4	+	2	1311	c.616delA	c.(616-618)ggfs	p.R206fs		NM_032177.3	NP_115553.2	Q9H814	PHAX_HUMAN	phosphorylated adaptor for RNA export	206	Necessary for interaction with CBP80 (By similarity).				ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	8						TGTCAAAGACAGGCTAGGGAA	0.423													18	79	---	---	---	---					
DIAPH1	1729	broad.mit.edu	37	5	140953368	140953368	+	Frame_Shift_Del	DEL	C	C	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr5:140953368delC	ENST00000253811.6	-	16	2189	c.2049delG	c.(2047-2049)ggfs	p.G683fs	DIAPH1_ENST00000518047.1_Frame_Shift_Del_p.G674fs|DIAPH1_ENST00000520569.1_Frame_Shift_Del_p.G629fs|DIAPH1_ENST00000398562.2_Frame_Shift_Del_p.G662fs|DIAPH1_ENST00000398557.4_Frame_Shift_Del_p.G683fs|DIAPH1_ENST00000398566.3_Frame_Shift_Del_p.G674fs|DIAPH1_ENST00000389054.3_Frame_Shift_Del_p.G683fs|DIAPH1_ENST00000389057.5_Frame_Shift_Del_p.G674fs			O60610	DIAP1_HUMAN	diaphanous-related formin 1	683	FH1.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTAGCACTCCCAGGCAAAG	0.622													2	4	---	---	---	---					
ZMIZ1	57178	broad.mit.edu	37	10	81070787	81070789	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr10:81070787_81070789delCTC	ENST00000334512.5	+	24	3514_3516	c.2942_2944delCTC	c.(2941-2946)gct>g	p.AP981del	ZMIZ1_ENST00000446377.2_Intron	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	981	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CACAGTGGGGCTCCTCCTCCTCC	0.635													7	190	---	---	---	---					
TBCEL	219899	broad.mit.edu	37	11	120918326	120918327	+	Frame_Shift_Ins	INS	-	-	A			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr11:120918326_120918327insA	ENST00000422003.2	+	3	411_412	c.223_224insA	c.(223-225)tgtfs	p.C75fs	TBCEL_ENST00000529397.1_Frame_Shift_Ins_p.C75fs	NM_152715.3	NP_689928.3	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	75						cytoplasm|cytoskeleton			TECTA/TBCEL(2)	endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TTTCTGCGCTCATGTGTCGGAA	0.411													12	175	---	---	---	---					
PDPK1	5170	broad.mit.edu	37	16	2611896	2611899	+	Frame_Shift_Del	DEL	CGAC	CGAC	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:2611896_2611899delCGAC	ENST00000342085.4	+	4	602_605	c.453_456delCGAC	c.(451-456)gafs	p.DD151fs	PDPK1_ENST00000389224.3_Frame_Shift_Del_p.DD124fs|PDPK1_ENST00000354836.5_Frame_Shift_Del_p.DD151fs|PDPK1_ENST00000268673.7_Intron|RP11-20I23.8_ENST00000569852.1_RNA|PDPK1_ENST00000441549.3_Frame_Shift_Del_p.DD151fs	NM_002613.4	NP_002604.1	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	151	Protein kinase.				actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	7		Ovarian(90;0.17)			Celecoxib(DB00482)	CATTTCAGGACGACGAGAAGCTGT	0.520													3	3	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372178	74372178	+	RNA	DEL	C	C	-	rs113003755		TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr16:74372178delC	ENST00000429810.2	-	0	2018																											gtctggaactcctgacttcag	0.502													3	6	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													10	61	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11097726	11097726	+	RNA	DEL	G	G	-			TCGA-WA-A7H4-01A-21D-A34J-08	TCGA-WA-A7H4-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58fe98ad-ea06-4565-bfe3-9f4220835c94	3b6cb478-482c-4391-b65e-3016b41a68a9	g.chr21:11097726delG	ENST00000470054.1	-	0	223									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCCAGTTTCAGCGAAGGCACT	0.587													9	38	---	---	---	---					
