Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMEM132D	121256	broad.mit.edu	37	12	129558772	129558772	+	Missense_Mutation	SNP	G	G	C			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr12:129558772G>C	ENST00000422113.2	-	9	3274	c.2948C>G	c.(2947-2949)tCg>tGg	p.S983W	TMEM132D_ENST00000389441.4_Missense_Mutation_p.S521W	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	983						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTCATCTTGCGAGGAGGCAAA	0.493000													72	140					0	0	0.870114	0	0
CTCFL	140690	broad.mit.edu	37	20	56093824	56093824	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr20:56093824G>A	ENST00000426658.2	-	4	1710	c.1049C>T	c.(1048-1050)gCc>gTc	p.A350V	CTCFL_ENST00000433949.2_Missense_Mutation_p.A350V|CTCFL_ENST00000539382.1_Missense_Mutation_p.A145V|CTCFL_ENST00000502686.2_Missense_Mutation_p.A88V|CTCFL_ENST00000423479.2_Missense_Mutation_p.A350V|CTCFL_ENST00000432255.2_Missense_Mutation_p.A350V|CTCFL_ENST00000429804.2_Missense_Mutation_p.A350V|CTCFL_ENST00000481655.1_5'UTR|CTCFL_ENST00000371196.2_Missense_Mutation_p.A350V|CTCFL_ENST00000422869.2_Missense_Mutation_p.A350V|CTCFL_ENST00000243914.3_Missense_Mutation_p.A350V|CTCFL_ENST00000422109.2_Missense_Mutation_p.A350V			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	350					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CTCCACACTGGCATACTTGCA	0.443000													5	272					0	0	0.217242	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33110533	33110533	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr13:33110533T>C	ENST00000267068.3	-	2	796	c.632A>G	c.(631-633)aAt>aGt	p.N211S	N4BP2L2_ENST00000446957.2_Missense_Mutation_p.N211S|N4BP2L2_ENST00000504114.1_Intron|N4BP2L2_ENST00000399396.3_Intron|N4BP2L2_ENST00000357505.6_Intron	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	211										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GAGACCATTATTATGACCCTC	0.353000													66	117					0	0	0.870114	0	0
OR51B4	79339	broad.mit.edu	37	11	5322806	5322806	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr11:5322806C>T	ENST00000380224.1	-	1	420	c.371G>A	c.(370-372)cGc>cAc	p.R124H	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R124H(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTGGTGTGCGGATGGCAAT	0.453000													4	138					0	0	0.150653	0	0
AZI1	22994	broad.mit.edu	37	17	79180662	79180662	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr17:79180662G>A	ENST00000269392.4	-	5	644	c.397C>T	c.(397-399)Ccc>Tcc	p.P133S	AZI1_ENST00000450824.2_Missense_Mutation_p.P133S|AZI1_ENST00000575907.1_Missense_Mutation_p.P133S|AZI1_ENST00000374782.3_Missense_Mutation_p.P133S	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	133					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			AAGCCCCGGGGCTGGTCATCC	0.652000													22	36					0	0	0.654019	0	0
ASIC3	9311	broad.mit.edu	37	7	150746136	150746136	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr7:150746136C>A	ENST00000357922.4	+	1	758	c.164C>A	c.(163-165)aCc>aAc	p.T55N	ASIC3_ENST00000297512.8_Missense_Mutation_p.T55N|ASIC3_ENST00000349064.5_Missense_Mutation_p.T55N	NM_020322.3	NP_064718.1	Q9UHC3	ACCN3_HUMAN	acid-sensing (proton-gated) ion channel 3	55					sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity										TCAGTGGCCACCTTCCTCTAC	0.662000													5	40					0.00198382	0.00240892	0.248553	1	0
CENPJ	55835	broad.mit.edu	37	13	25458475	25458475	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr13:25458475G>A	ENST00000381884.4	-	14	3789	c.3604C>T	c.(3604-3606)Cca>Tca	p.P1202S	CENPJ_ENST00000545981.1_3'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1202					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CTTTGGTCTGGCATGACCTGC	0.453000													4	131					0	0	0.184627	0	0
GPX1	2876	broad.mit.edu	37	3	49395503	49395503	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr3:49395503C>A	ENST00000419783.1	-	1	530	c.209G>T	c.(208-210)gGc>gTc	p.G70V	GPX1_ENST00000419349.1_Missense_Mutation_p.G70V|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	70					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CACCACCAGGCCCCGGGGTCC	0.697000													4	17					0.000602214	0.000758344	0.184627	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121636616	121636616	+	Missense_Mutation	SNP	A	A	T			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr7:121636616A>T	ENST00000393386.2	+	9	1520	c.1109A>T	c.(1108-1110)gAc>gTc	p.D370V	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.D370V	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	370	Fibronectin type-III.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GGCTATCAAGACTTGGTAACT	0.338000													68	232					0	0	0.870114	0	0
MAP1B	4131	broad.mit.edu	37	5	71499625	71499625	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr5:71499625G>A	ENST00000296755.7	+	6	7546	c.7248G>A	c.(7246-7248)atG>atA	p.M2416I		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2416						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GCAGCAACATGCAGGTGAGAA	0.567000													9	23					0	0	0.335167	0	0
NEIL1	79661	broad.mit.edu	37	15	75647015	75647015	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr15:75647015G>A	ENST00000564784.1	+	10	1587	c.958G>A	c.(958-960)Gcc>Acc	p.A320T	NEIL1_ENST00000355059.4_Missense_Mutation_p.A320T|NEIL1_ENST00000569035.1_Missense_Mutation_p.A320T			Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1 (E. coli)	320					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)	13						TCCAAGCAAGGCCCCTTCCAG	0.632000								Base excision repair (BER), DNA glycosylases					20	45					0	0	0.575678	0	0
CCDC15	80071	broad.mit.edu	37	11	124857562	124857562	+	Silent	SNP	A	A	G			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr11:124857562A>G	ENST00000529051.1	+	8	1699	c.1440A>G	c.(1438-1440)ttA>ttG	p.L480L	CCDC15_ENST00000344762.5_Silent_p.L480L			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	480						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGAATTTTTTATCTAGAGACC	0.408000													5	254					0	0	0.184627	0	0
RRBP1	6238	broad.mit.edu	37	20	17641122	17641122	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr20:17641122C>T	ENST00000377813.1	-	3	334	c.31G>A	c.(31-33)Gtt>Att	p.V11I	RRBP1_ENST00000246043.4_Missense_Mutation_p.V11I|RRBP1_ENST00000455029.2_Intron|RRBP1_ENST00000377807.2_Missense_Mutation_p.V11I|RRBP1_ENST00000360807.4_Missense_Mutation_p.V11I			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	11					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						AAGACCACAACCCCCAAGGTT	0.438000													20	58					0	0	0.575678	0	0
ATAD2B	54454	broad.mit.edu	37	2	23977134	23977134	+	Missense_Mutation	SNP	A	A	C			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr2:23977134A>C	ENST00000238789.5	-	27	4593	c.4250T>G	c.(4249-4251)gTt>gGt	p.V1417G	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1417							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGCTGATCAACTGCCAGATT	0.318000													4	12					0	0	0.150653	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28961222	28961222	+	RNA	SNP	C	C	G			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr17:28961222C>G	ENST00000417404.1	+	0	1480				SMURF2P1_ENST00000578265.1_RNA																							TGACATTCTTCTTCTGTCATT	0.378000													3	3					0	0	0.150653	0	0
GRK6	2870	broad.mit.edu	37	5	176857936	176857936	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr5:176857936T>C	ENST00000355472.5	+	2	284	c.116T>C	c.(115-117)aTc>aCc	p.I39T	GRK6_ENST00000528793.1_Missense_Mutation_p.I39T|GRK6_ENST00000393576.3_Missense_Mutation_p.I39T|GRK6_ENST00000355958.5_Missense_Mutation_p.I39T|GRK6_ENST00000507633.1_Missense_Mutation_p.I39T	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	39	N-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCCTCACATCAGCCAGTGC	0.647000													4	11					0	0	0.278610	0	0
ZNF214	7761	broad.mit.edu	37	11	7022784	7022784	+	Missense_Mutation	SNP	T	T	G			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr11:7022784T>G	ENST00000278314.4	-	3	445	c.130A>C	c.(130-132)Aac>Cac	p.N44H	ZNF214_ENST00000536068.1_Missense_Mutation_p.N44H|ZNF214_ENST00000531083.1_5'UTR	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TCATTCCAGTTTTCTAGAAAA	0.338000													47	94					0	0	0.870114	0	0
SLC12A4	6560	broad.mit.edu	37	16	67985066	67985066	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr16:67985066C>T	ENST00000422611.2	-	8	1319	c.1280G>A	c.(1279-1281)gGc>gAc	p.G427D	SLC12A4_ENST00000338335.3_Missense_Mutation_p.G425D|SLC12A4_ENST00000541864.2_Missense_Mutation_p.G394D|SLC12A4_ENST00000576616.1_Missense_Mutation_p.G425D|SLC12A4_ENST00000316341.3_Missense_Mutation_p.G425D|SLC12A4_ENST00000572037.1_Missense_Mutation_p.G377D|SLC12A4_ENST00000537830.2_Missense_Mutation_p.G419D	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	425					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GAAGAAGATGCCGACCAGCAC	0.622000													4	129					0	0	0.150653	0	0
PYGM	5837	broad.mit.edu	37	11	64514806	64514806	+	Missense_Mutation	SNP	A	A	C			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr11:64514806A>C	ENST00000164139.3	-	18	2600	c.2202T>G	c.(2200-2202)gaT>gaG	p.D734E	PYGM_ENST00000377432.3_Missense_Mutation_p.D646E	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	734					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	CAGGAATGCGATCGTAGTACT	0.552000													20	44					0	0	0.654019	0	0
RPH3A	22895	broad.mit.edu	37	12	113303233	113303233	+	Missense_Mutation	SNP	G	G	A	rs141736304		TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr12:113303233G>A	ENST00000389385.4	+	6	742	c.245G>A	c.(244-246)cGc>cAc	p.R82H	RPH3A_ENST00000447659.2_Missense_Mutation_p.R33H|RPH3A_ENST00000415485.3_Missense_Mutation_p.R82H|RPH3A_ENST00000543106.2_Missense_Mutation_p.R82H|RPH3A_ENST00000420983.2_Missense_Mutation_p.R82H|RPH3A_ENST00000551052.1_Missense_Mutation_p.R78H|RPH3A_ENST00000548866.1_Missense_Mutation_p.R33H	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	82	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CTGGTGGACCGCCTAGAAAAC	0.542000													58	127					0	0	0.870114	0	0
GPR107	57720	broad.mit.edu	37	9	132890996	132890996	+	Silent	SNP	C	C	T			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr9:132890996C>T	ENST00000372406.1	+	19	2169	c.1662C>T	c.(1660-1662)taC>taT	p.Y554Y	GPR107_ENST00000372410.3_Silent_p.Y525Y|GPR107_ENST00000347136.6_Silent_p.Y506Y	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	554						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				ATAACCCCTACCTACAACTTT	0.468000													78	163					0	0	0.870114	0	0
SLC12A1	6557	broad.mit.edu	37	15	48559860	48559860	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr15:48559860G>A	ENST00000396577.3	+	18	2472	c.2257G>A	c.(2257-2259)Gca>Aca	p.A753T	SLC12A1_ENST00000558405.1_Missense_Mutation_p.A753T|SLC12A1_ENST00000380993.3_Missense_Mutation_p.A753T	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	753					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TGCAGTGGCGGCAGACTGTTT	0.458000													4	88					0	0	0.150653	0	0
SAG	6295	broad.mit.edu	37	2	234237129	234237129	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr2:234237129C>T	ENST00000409110.1	+	8	748	c.518C>T	c.(517-519)tCc>tTc	p.S173F	SAG_ENST00000449594.2_Missense_Mutation_p.S39F	NM_000541.4	NP_000532.2	P10523	ARRS_HUMAN	S-antigen; retina and pineal gland (arrestin)	173					rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			cervix(1)|kidney(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		CACAGGAGCTCCGTGCGATTA	0.587000													30	53					0	0	0.706142	0	0
DOCK4	9732	broad.mit.edu	37	7	111424166	111424166	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr7:111424166C>A	ENST00000428084.1	-	33	3687	c.3415G>T	c.(3415-3417)Ggt>Tgt	p.G1139C	DOCK4_ENST00000437633.1_Intron|DOCK4_ENST00000494651.2_Missense_Mutation_p.G13C			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1134	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GGATAGGGACCAAATAGTGGA	0.343000													6	16					0.0381472	0.0432335	0.278610	1	0
ZNF320	162967	broad.mit.edu	37	19	53384636	53384636	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr19:53384636T>C	ENST00000595635.1	-	8	1244	c.743A>G	c.(742-744)aAt>aGt	p.N248S	ZNF320_ENST00000597909.1_Intron|ZNF320_ENST00000391781.2_Missense_Mutation_p.N248S|ZNF320_ENST00000600930.1_Intron	NM_207333.2	NP_997216.2	A2RRD8	ZN320_HUMAN	zinc finger protein 320	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(4)|large_intestine(5)|liver(1)|lung(10)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(134;0.0534)		GCCACACTCATTACACTTATA	0.393000													76	145					0	0	0.870114	0	0
TGM6	343641	broad.mit.edu	37	20	2411617	2411617	+	Missense_Mutation	SNP	G	G	T			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr20:2411617G>T	ENST00000202625.2	+	12	1972	c.1911G>T	c.(1909-1911)aaG>aaT	p.K637N	TGM6_ENST00000381423.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	637					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	AGAGAGTGAAGGACTGTGCGC	0.597000													5	193					0.014758	0.0173025	0.184627	1	0
ZNF782	158431	broad.mit.edu	37	9	99581991	99581991	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B8-4619-01A-02D-1553-08	TCGA-B8-4619-11A-01D-1553-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e16d8c96-e679-4c87-ad6d-5e58d6a9d267	4c1d2f74-ab88-4783-ae81-e99a218211c7	g.chr9:99581991delA	ENST00000481138.1	-	6	975	c.314delT	c.(313-315)tafs	p.L105fs	ZNF782_ENST00000535338.1_5'UTR|ZNF782_ENST00000466833.1_5'UTR	NM_001001662.1	NP_001001662.1	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(8)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)	33		Acute lymphoblastic leukemia(62;0.0527)				ATTGGTGAATAAAACTTGCAA	0.323													31	67	---	---	---	---					
