Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAP3K1	4214	broad.mit.edu	37	5	56184111	56184111	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:56184111T>G	ENST00000399503.3	+	19	4316	c.4316T>G	c.(4315-4317)aTt>aGt	p.I1439S		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	1439	Protein kinase.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GGCTGTGCTATTATAGAAATG	0.348000													51	54					0	0	0.870114	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72511387	72511387	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr10:72511387A>G	ENST00000373208.1	+	17	2590	c.2590A>G	c.(2590-2592)Aag>Gag	p.K864E	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.K861E	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	861	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CCCCTGCAGCAAGGCCTGTGG	0.622000													14	26					0	0	0.457914	0	0
LRRK2	120892	broad.mit.edu	37	12	40757280	40757280	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:40757280A>G	ENST00000298910.7	+	48	7163	c.7105A>G	c.(7105-7107)Aat>Gat	p.N2369D		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2369					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGCTAAGCAAAATAGCCCTGT	0.358000													29	59					0	0	0.740014	0	0
MYL10	93408	broad.mit.edu	37	7	101265479	101265479	+	Splice_Site	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr7:101265479G>T	ENST00000223167.4	-	5	528	c.349_splice	c.e5-1	p.G117_splice		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	117	EF-hand 1.					mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						CATTGATGCGGCCTGTGGGAG	0.597000													13	24					3.27435e-08	3.4976e-08	0.457914	1	0
TTN	7273	broad.mit.edu	37	2	179467028	179467028	+	Silent	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:179467028G>T	ENST00000589042.1	-	283	55325	c.55101C>A	c.(55099-55101)atC>atA	p.I18367I	TTN_ENST00000460472.2_Silent_p.I9302I|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.I9427I|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000591111.1_Silent_p.I16726I|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Silent_p.I15799I|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Silent_p.I9494I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16726	Fibronectin type-III 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGTGGCAGGGATCTCCCCAG	0.368000													12	73					0.00185496	0.00190912	0.435327	1	0
RPAP1	26015	broad.mit.edu	37	15	41823330	41823330	+	Silent	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr15:41823330C>T	ENST00000304330.4	-	7	950	c.834G>A	c.(832-834)gaG>gaA	p.E278E	RPAP1_ENST00000568413.1_5'UTR|RPAP1_ENST00000561603.1_Silent_p.E278E	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	278						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCCTCTGCTCCTCAGAGGCTG	0.562000													87	165					0	0	0.870114	0	0
IQCH	64799	broad.mit.edu	37	15	67664907	67664907	+	Silent	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr15:67664907T>C	ENST00000335894.4	+	9	1278	c.1212T>C	c.(1210-1212)atT>atC	p.I404I	IQCH_ENST00000360277.4_Silent_p.I156I|IQCH_ENST00000546225.1_Silent_p.I152I|IQCH_ENST00000358767.3_Silent_p.I231I	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	404										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		TGATTGCCATTGCTTGGCTGT	0.453000													6	184					0	0	0.248553	0	0
TRMT13	54482	broad.mit.edu	37	1	100613725	100613725	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:100613725C>T	ENST00000370141.2	+	10	1099	c.1093C>T	c.(1093-1095)Cag>Tag	p.Q365*		NM_019083.2	NP_061956.2			tRNA methyltransferase 13 homolog (S. cerevisiae)																		CCATTATTTCCAGCGAATGAG	0.428000													20	71					0	0	0.575678	0	0
ZDHHC16	84287	broad.mit.edu	37	10	99213413	99213413	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr10:99213413C>T	ENST00000393760.1	+	7	1032	c.683C>T	c.(682-684)gCc>gTc	p.A228V	ZDHHC16_ENST00000370842.2_Missense_Mutation_p.A228V|ZDHHC16_ENST00000370846.4_Intron|ZDHHC16_ENST00000353979.3_Missense_Mutation_p.A189V|ZDHHC16_ENST00000495735.1_3'UTR|ZDHHC16_ENST00000352634.4_Missense_Mutation_p.A228V|ZDHHC16_ENST00000370854.3_Missense_Mutation_p.A228V|ZDHHC16_ENST00000345745.5_Missense_Mutation_p.A163V	NM_198046.1	NP_932163.1	Q969W1	ZDH16_HUMAN	zinc finger, DHHC-type containing 16	228					apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	14		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		GCTTATGCTGCCATTGAGGTG	0.507000													25	50					0	0	0.654019	0	0
SUPT6H	6830	broad.mit.edu	37	17	27000506	27000506	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:27000506A>C	ENST00000314616.6	+	2	370	c.87A>C	c.(85-87)aaA>aaC	p.K29N	SUPT6H_ENST00000347486.4_Missense_Mutation_p.K29N	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	29	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TCACCAAGAAATTTGTGGAAG	0.493000													11	29					0	0	0.435327	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202430518	202430518	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:202430518G>A	ENST00000439140.1	-	9	955	c.911C>T	c.(910-912)gCt>gTt	p.A304V	ALS2CR11_ENST00000439802.1_Missense_Mutation_p.A304V|ALS2CR11_ENST00000450242.1_Missense_Mutation_p.A304V|ALS2CR11_ENST00000286195.3_Missense_Mutation_p.A304V	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	304										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						GGATTGCACAGCTGGAGTCCC	0.378000													23	34					0	0	0.624587	0	0
C11orf58	10944	broad.mit.edu	37	11	16774369	16774369	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:16774369T>A	ENST00000525684.1	+	3	306	c.185T>A	c.(184-186)cTc>cAc	p.L62H	C11orf58_ENST00000228136.4_Silent_p.S82S|C11orf58_ENST00000422258.2_Silent_p.S38S			O00193	SMAP_HUMAN	chromosome 11 open reading frame 58	0										NS(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)	7						AACTGGAGTCTCAATATCAGC	0.348000													27	50					0	0	0.740014	0	0
MOS	4342	broad.mit.edu	37	8	57025710	57025710	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr8:57025710G>A	ENST00000311923.1	-	1	831	c.832C>T	c.(832-834)Ccg>Tcg	p.P278S		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	278	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			CCCGAATACGGCGCCTGCTTG	0.637000													4	50					0	0	0.150653	0	0
MUC16	94025	broad.mit.edu	37	19	9076119	9076119	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr19:9076119A>C	ENST00000397910.4	-	3	11530	c.11327T>G	c.(11326-11328)tTg>tGg	p.L3776W		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3777	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAGAAGGGCAACTGTGAGGT	0.517000													40	100					0	0	0.847076	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47424034	47424034	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr19:47424034T>C	ENST00000404338.3	+	1	2102	c.2102T>C	c.(2101-2103)aTt>aCt	p.I701T		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	701					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTTACATTAATTTTGGTTAAC	0.443000													10	10					0	0	0.335167	0	0
KPNB1	3837	broad.mit.edu	37	17	45747173	45747173	+	Silent	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:45747173C>T	ENST00000290158.4	+	11	1761	c.1354C>T	c.(1354-1356)Ctg>Ttg	p.L452L	KPNB1_ENST00000537679.1_Silent_p.L236L|KPNB1_ENST00000540627.1_Silent_p.L307L|KPNB1_ENST00000535458.2_Silent_p.L307L	NM_001276453.1|NM_002265.4	NP_001263382.1|NP_002256.2	Q14974	IMB1_HUMAN	karyopherin (importin) beta 1	452					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			breast(1)|ovary(1)|pancreas(1)|skin(1)	4						CTTGGCTCCCCTGCTACAGTG	0.502000													50	74					0	0	0.870114	0	0
BCL9	607	broad.mit.edu	37	1	147092835	147092835	+	Silent	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:147092835C>T	ENST00000234739.3	+	8	3614	c.2874C>T	c.(2872-2874)tcC>tcT	p.S958S		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	958	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					CCATGGCCTCCCCAGCCATGC	0.527000			T	"""IGH@, IGL@"""	B-ALL								10	52					0	0	0.411799	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					5	75					0	0	0.411799	0	0
CSRNP2	81566	broad.mit.edu	37	12	51467805	51467805	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:51467805A>T	ENST00000228515.1	-	3	509	c.212T>A	c.(211-213)gTg>gAg	p.V71E		NM_030809.2	NP_110436.1	Q9H175	CSRN2_HUMAN	cysteine-serine-rich nuclear protein 2	71					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	14						GTATACAGTCACCTGGTCAAA	0.532000													37	76					0	0	0.819951	0	0
EEA1	8411	broad.mit.edu	37	12	93192829	93192829	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:93192829T>C	ENST00000322349.8	-	21	3070	c.2806A>G	c.(2806-2808)Atg>Gtg	p.M936V		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	936					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						TGTTCCTGCATTGAATTGAGT	0.333000													8	37					0	0	0.335167	0	0
SYNE1	23345	broad.mit.edu	37	6	152557402	152557402	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr6:152557402A>C	ENST00000367255.5	-	110	20837	c.20236T>G	c.(20236-20238)Tta>Gta	p.L6746V	SYNE1_ENST00000423061.1_Missense_Mutation_p.L6675V|SYNE1_ENST00000356820.4_Missense_Mutation_p.L1270V|SYNE1_ENST00000448038.1_Missense_Mutation_p.L6675V|SYNE1_ENST00000265368.4_Missense_Mutation_p.L6746V|SYNE1_ENST00000341594.5_Missense_Mutation_p.L6358V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6746					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTTGATATAATTTGGGCTGG	0.313000										HNSCC(10;0.0054)			31	54					0	0	0.729181	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													6	70					0	0	0.248553	0	0
CDR1	1038	broad.mit.edu	37	X	139866077	139866077	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:139866077C>T	ENST00000370532.2	-	1	646	c.455G>A	c.(454-456)aGa>aAa	p.R152K		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	152	6 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TCCTGAAAATCTACGTCTTCC	0.443000													107	198					0	0	0.870114	0	0
ARMC4	55130	broad.mit.edu	37	10	28149666	28149666	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr10:28149666C>G	ENST00000305242.5	-	19	3001	c.2909G>C	c.(2908-2910)cGt>cCt	p.R970P	ARMC4_ENST00000537576.1_Missense_Mutation_p.R662P|ARMC4_ENST00000545014.1_Missense_Mutation_p.R495P	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	970							binding	p.R970H(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TTTCAGATAACGCACTAGTGG	0.488000													27	59					0	0	0.706142	0	0
TMED2	10959	broad.mit.edu	37	12	124069310	124069310	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:124069310A>G	ENST00000262225.3	+	1	233	c.127A>G	c.(127-129)Atg>Gtg	p.M43V	RP11-486O12.2_ENST00000498967.2_lincRNA	NM_006815.3	NP_006806.1	Q15363	TMED2_HUMAN	transmembrane emp24 domain trafficking protein 2	43	GOLD.				protein transport|vesicle-mediated transport	COPI coated vesicle membrane|ER-Golgi intermediate compartment|integral to membrane|microsome|zymogen granule membrane	protein binding			kidney(1)|large_intestine(4)|lung(1)|prostate(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000138)|Epithelial(86;0.000613)|all cancers(50;0.00745)		GGGCACCAAGATGGGCCTCAT	0.647000													26	49					0	0	0.717897	0	0
DENND5A	23258	broad.mit.edu	37	11	9228258	9228258	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:9228258C>T	ENST00000328194.3	-	3	573	c.253G>A	c.(253-255)Gta>Ata	p.V85I	DENND5A_ENST00000530044.1_Missense_Mutation_p.V85I	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	85	UDENN.							p.V85L(1)		breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTCCATTCTACGTTCTCAGGA	0.348000													58	130					0	0	0.870114	0	0
DNMT3B	1789	broad.mit.edu	37	20	31383331	31383331	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr20:31383331C>A	ENST00000328111.2	+	11	1564	c.1243C>A	c.(1243-1245)Cag>Aag	p.Q415K	DNMT3B_ENST00000443239.3_Missense_Mutation_p.Q353K|DNMT3B_ENST00000201963.3_Missense_Mutation_p.Q407K|DNMT3B_ENST00000456297.2_Missense_Mutation_p.Q319K|DNMT3B_ENST00000344505.4_Missense_Mutation_p.Q395K|DNMT3B_ENST00000348286.2_Missense_Mutation_p.Q395K|DNMT3B_ENST00000353855.2_Missense_Mutation_p.Q395K|DNMT3B_ENST00000375623.4_Silent_p.I304I	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	415					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGATGAAGATCAGAGCCGAGG	0.557000													10	36					3.86212e-05	4.06387e-05	0.361761	1	0
CATSPERG	57828	broad.mit.edu	37	19	38857909	38857909	+	Silent	SNP	C	C	T	rs144017491	byFrequency	TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr19:38857909C>T	ENST00000409235.3	+	23	2842	c.2727C>T	c.(2725-2727)tgC>tgT	p.C909C	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Silent_p.C869C	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	909					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						ACTTTGACTGCGTTAACGTGA	0.567000													11	23					0	0	0.361761	0	0
C12orf54	121273	broad.mit.edu	37	12	48888763	48888763	+	Splice_Site	SNP	A	A	G	rs2705132	by1000genomes	TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:48888763A>G	ENST00000314014.2	+	8	555		c.e8+1		C12orf54_ENST00000548364.1_Splice_Site|RP11-722P11.4_ENST00000551847.1_RNA	NM_152319.3	NP_689532.1	Q6X4T0	CL054_HUMAN	chromosome 12 open reading frame 54											endometrium(1)|large_intestine(4)	5						CTTCCGCCAGATGCTTTACCC	0.542000													3	63					0	0	0.115264	0	0
BAI3	577	broad.mit.edu	37	6	70071056	70071056	+	Silent	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr6:70071056C>A	ENST00000370598.1	+	29	4712	c.3891C>A	c.(3889-3891)gtC>gtA	p.V1297V	BAI3_ENST00000546190.1_Silent_p.V261V|BAI3_ENST00000238918.8_Silent_p.V503V	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1297					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TGGACATAGTCCATCCTCAAG	0.368000													13	50					4.3838e-07	4.64749e-07	0.435327	1	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22472946	22472946	+	RNA	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr15:22472946C>A	ENST00000557788.2	-	0	324																											ACGGCCCTGTCCGCGGCGGTC	0.602000													57	498					3.30226e-22	3.81655e-22	0.870114	1	0
CNDP1	84735	broad.mit.edu	37	18	72247364	72247364	+	Splice_Site	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr18:72247364A>G	ENST00000582365.1	+	9	1104		c.e9-1		CNDP1_ENST00000358821.3_Splice_Site			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)						proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GTCACCTTTTAGGTGACACGA	0.348000													6	17					0	0	0.248553	0	0
AKAP9	10142	broad.mit.edu	37	7	91722412	91722412	+	Splice_Site	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr7:91722412A>G	ENST00000359028.2	+	39	9597	c.9370_splice	c.e39-1	p.E3124_splice	AKAP9_ENST00000356239.3_Splice_Site_p.E3120_splice|AKAP9_ENST00000358100.2_Splice_Site_p.E3070_splice			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3124					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCTGTGTAGAACTCTTGGAAT	0.358000			T	BRAF	papillary thyroid								17	34					0	0	0.520397	0	0
C6	729	broad.mit.edu	37	5	41186209	41186209	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:41186209T>G	ENST00000263413.3	-	6	953	c.689A>C	c.(688-690)tAc>tCc	p.Y230S	C6_ENST00000475349.1_Intron|C6_ENST00000337836.5_Missense_Mutation_p.Y230S	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	230	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CGGAACACGGTATGGATTACT	0.438000													36	47					0	0	0.788014	0	0
THOP1	7064	broad.mit.edu	37	19	2794798	2794798	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr19:2794798C>T	ENST00000307741.6	+	3	469	c.266C>T	c.(265-267)tCc>tTc	p.S89F		NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	89					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCATGTTTCCCCCTCCAAG	0.557000													65	119					0	0	0.870114	0	0
GK	2710	broad.mit.edu	37	X	30738149	30738149	+	Silent	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:30738149G>A	ENST00000378943.3	+	15	1334	c.1155G>A	c.(1153-1155)caG>caA	p.Q385Q	GK-AS1_ENST00000464659.1_RNA|GK_ENST00000427190.1_Silent_p.Q186Q|GK_ENST00000378945.3_Silent_p.Q385Q|GK_ENST00000378946.3_Silent_p.Q391Q|RP11-242C19.2_ENST00000497961.1_RNA	NM_001128127.2	NP_001121599.1	P32189	GLPK_HUMAN	glycerol kinase	391					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)|large_intestine(3)	4						GACTCACTCAGTTCACCAATA	0.333000													5	98					0	0	0.184627	0	0
NEURL4	84461	broad.mit.edu	37	17	7228990	7228990	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:7228990G>T	ENST00000399464.2	-	7	1351	c.1336C>A	c.(1336-1338)Cta>Ata	p.L446I	NEURL4_ENST00000315614.7_Missense_Mutation_p.L446I|NEURL4_ENST00000570460.1_Missense_Mutation_p.L424I	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AAGAAGTGTAGGGCAGAGTTG	0.567000													27	79					4.02929e-09	4.37023e-09	0.750413	1	0
DIAPH1	1729	broad.mit.edu	37	5	140896574	140896574	+	Splice_Site	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:140896574G>T	ENST00000253811.6	-	28	3806	c.3664_splice	c.e28-1	p.A1222_splice	DIAPH1_ENST00000398562.2_Splice_Site_p.A1197_splice|DIAPH1_ENST00000520569.1_Splice_Site_p.A1164_splice|DIAPH1_ENST00000518047.1_Splice_Site_p.A1209_splice|DIAPH1_ENST00000398557.4_Splice_Site_p.A1221_splice|DIAPH1_ENST00000398566.3_Splice_Site_p.A1213_splice|DIAPH1_ENST00000389054.3_Splice_Site_p.A1218_splice|DIAPH1_ENST00000389057.5_Splice_Site_p.A1212_splice			O60610	DIAP1_HUMAN	diaphanous-related formin 1	1221	DAD.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTCCTGTTGGCTGCAAGAG	0.498000													12	20					7.03913e-09	7.57646e-09	0.411799	1	0
MTOR	2475	broad.mit.edu	37	1	11174411	11174411	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:11174411C>T	ENST00000361445.4	-	53	7340	c.7264G>A	c.(7264-7266)Gtc>Atc	p.V2422I	MTOR_ENST00000376838.1_Missense_Mutation_p.V627I	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2422	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GGGTCATAGACAAAGGCTTCC	0.527000													31	51					0	0	0.779181	0	0
RARG	5916	broad.mit.edu	37	12	53621180	53621180	+	Silent	SNP	G	G	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:53621180G>C	ENST00000425354.2	-	3	637	c.150C>G	c.(148-150)ggC>ggG	p.G50G	RARG_ENST00000543762.1_Intron|RARG_ENST00000394426.1_Silent_p.G50G|RARG_ENST00000327550.3_Intron	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	50	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGTCAGGCTGGCCCAGGCCCC	0.607000													26	48					0	0	0.717897	0	0
TBXAS1	6916	broad.mit.edu	37	7	139611072	139611072	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr7:139611072G>A	ENST00000263552.6	+	8	826	c.288G>A	c.(286-288)atG>atA	p.M96I	TBXAS1_ENST00000414508.2_Missense_Mutation_p.M96I|TBXAS1_ENST00000455353.1_Missense_Mutation_p.M95I|TBXAS1_ENST00000448866.1_Missense_Mutation_p.M95I|TBXAS1_ENST00000425687.1_Missense_Mutation_p.M28I|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000458722.1_Missense_Mutation_p.M95I|TBXAS1_ENST00000539806.1_Missense_Mutation_p.M96I|TBXAS1_ENST00000416849.2_Missense_Mutation_p.M96I|TBXAS1_ENST00000411653.1_Missense_Mutation_p.M95I|TBXAS1_ENST00000336425.5_Missense_Mutation_p.M95I|TBXAS1_ENST00000436047.2_Missense_Mutation_p.M96I	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	95					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					AGCCAGACATGATCAAGCAGG	0.393000													61	104					0	0	0.870114	0	0
ASB1	51665	broad.mit.edu	37	2	239353298	239353298	+	Silent	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:239353298G>A	ENST00000264607.4	+	4	1057	c.810G>A	c.(808-810)tcG>tcA	p.S270S	ASB1_ENST00000409297.1_Silent_p.S169S	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	270					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		AGTGGGAATCGCTGGGCCCAG	0.542000													30	68					0	0	0.760397	0	0
SEMA6C	10500	broad.mit.edu	37	1	151108514	151108514	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:151108514T>A	ENST00000341697.3	-	13	2923	c.1232A>T	c.(1231-1233)cAt>cTt	p.H411L				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	411	Sema.					integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TAGAGGCTGATGGGTGACAGG	0.567000													25	51					0	0	0.693898	0	0
RPA1	6117	broad.mit.edu	37	17	1782610	1782610	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:1782610G>A	ENST00000254719.5	+	10	971	c.861G>A	c.(859-861)atG>atA	p.M287I		NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	287					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						CTTCCGTCATGCCCTGTGAGG	0.443000								Nucleotide excision repair (NER)					25	62					0	0	0.667858	0	0
DPEP1	1800	broad.mit.edu	37	16	89702720	89702720	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr16:89702720C>T	ENST00000393092.3	+	4	577	c.286C>T	c.(286-288)Cgg>Tgg	p.R96W	DPEP1_ENST00000261615.4_Missense_Mutation_p.R96W|DPEP1_ENST00000421184.1_Missense_Mutation_p.R96W	NM_004413.3	NP_004404.1	P16444	DPEP1_HUMAN	dipeptidase 1 (renal)	96					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(2)|lung(10)|prostate(1)|urinary_tract(1)	14		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	AGACGCCGTGCGGAGGACGCT	0.647000													4	17					0	0	0.150653	0	0
KIF1C	10749	broad.mit.edu	37	17	4916956	4916956	+	Silent	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:4916956C>T	ENST00000320785.5	+	17	1857	c.1500C>T	c.(1498-1500)caC>caT	p.H500H		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	500					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						AGACTCCCCACCTGGTGAACC	0.597000													16	23					0	0	0.557998	0	0
ARID5B	84159	broad.mit.edu	37	10	63851371	63851371	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr10:63851371A>G	ENST00000279873.7	+	10	2559	c.2149A>G	c.(2149-2151)Atc>Gtc	p.I717V	ARID5B_ENST00000309334.5_Missense_Mutation_p.I474V	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	717					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					ACCCCCTTTGATCAGCAAAAA	0.552000													32	74					0	0	0.804634	0	0
TTI1	9675	broad.mit.edu	37	20	36642156	36642156	+	Silent	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr20:36642156G>T	ENST00000373448.2	-	3	301	c.63C>A	c.(61-63)ctC>ctA	p.L21L	TTI1_ENST00000487362.1_5'UTR|TTI1_ENST00000373447.3_Silent_p.L21L|TTI1_ENST00000449821.1_Silent_p.L21L	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	21							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						GGGTCTTTGTGAGCTGAACAC	0.512000													53	98					5.19286e-32	6.15288e-32	0.870114	1	0
NPR1	4881	broad.mit.edu	37	1	153653153	153653153	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:153653153G>T	ENST00000368680.3	+	2	1370	c.898G>T	c.(898-900)Gtc>Ttc	p.V300F		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	300					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TGGGCAGGATGTCAGTGCCCG	0.592000													17	19					1.02788e-11	1.13228e-11	0.520397	1	0
EFNB1	1947	broad.mit.edu	37	X	68060246	68060246	+	Nonsense_Mutation	SNP	A	A	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:68060246A>T	ENST00000204961.4	+	5	1570	c.790A>T	c.(790-792)Aag>Tag	p.K264*		NM_004429.4	NP_004420.1	P98172	EFNB1_HUMAN	ephrin-B1	264					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						CCTACTACTGAAGCTACGCAA	0.617000													11	34					0	0	0.435327	0	0
IRF7	3665	broad.mit.edu	37	11	614335	614335	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:614335G>T	ENST00000397566.1	-	4	966	c.557C>A	c.(556-558)cCt>cAt	p.P186H	IRF7_ENST00000397570.1_Missense_Mutation_p.P173H|IRF7_ENST00000525445.1_Missense_Mutation_p.P67H|IRF7_ENST00000330243.5_Missense_Mutation_p.P186H|IRF7_ENST00000397562.3_Intron|IRF7_ENST00000348655.6_Missense_Mutation_p.P173H|IRF7_ENST00000397574.2_Missense_Mutation_p.P173H	NM_004031.2	NP_004022.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7	173					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCTGGGGCAGGGAGGGGGCC	0.647000													8	9					1.33987e-11	1.46451e-11	0.361761	1	0
RRBP1	6238	broad.mit.edu	37	20	17600277	17600277	+	Splice_Site	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr20:17600277C>T	ENST00000377813.1	-	19	3979		c.e19+1		RRBP1_ENST00000360807.4_Splice_Site|RRBP1_ENST00000377807.2_Splice_Site|RRBP1_ENST00000246043.4_Splice_Site|RRBP1_ENST00000468428.1_5'UTR|RRBP1_ENST00000455029.2_Splice_Site			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1						protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						GGCAGACTCACCCCTGCCACC	0.647000													6	24					0	0	0.248553	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415007	210415007	+	Silent	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:210415007A>C	ENST00000367012.3	+	4	626	c.396A>C	c.(394-396)atA>atC	p.I132I	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	132	SERTA.						protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		CTGTCCTTATAAACAATTTGA	0.408000													50	78					0	0	0.870114	0	0
TUBA1C	84790	broad.mit.edu	37	12	49666782	49666782	+	Silent	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:49666782T>C	ENST00000301072.6	+	4	1397	c.1122T>C	c.(1120-1122)gcT>gcC	p.A374A	TUBA1C_ENST00000541364.1_Silent_p.A444A|RP11-161H23.5_ENST00000550468.2_RNA	NM_032704.3	NP_116093.1	Q9BQE3	TBA1C_HUMAN	tubulin, alpha 1c	374					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)	13						TACAGAGAGCTGTGTGCATGC	0.562000													19	36					0	0	0.575678	0	0
KLHL13	90293	broad.mit.edu	37	X	117043342	117043342	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:117043342T>C	ENST00000371876.1	-	4	3556	c.1135A>G	c.(1135-1137)Aag>Gag	p.K379E	KLHL13_ENST00000541812.1_Missense_Mutation_p.K414E|KLHL13_ENST00000371878.1_Missense_Mutation_p.K379E|KLHL13_ENST00000540167.1_Missense_Mutation_p.K414E|KLHL13_ENST00000262820.3_Missense_Mutation_p.K430E|KLHL13_ENST00000469946.1_Missense_Mutation_p.K379E|KLHL13_ENST00000539496.1_Missense_Mutation_p.K433E|KLHL13_ENST00000371882.1_Missense_Mutation_p.K379E|KLHL13_ENST00000545703.1_Missense_Mutation_p.K388E			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	430					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AAGGTGCGCTTTTCATTTAAA	0.398000													39	47					0	0	0.812448	0	0
RGS18	64407	broad.mit.edu	37	1	192128415	192128415	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:192128415G>A	ENST00000367460.3	+	2	366	c.185G>A	c.(184-186)cGc>cAc	p.R62H	RGS18_ENST00000481707.1_3'UTR	NM_130782.2	NP_570138.1	Q9NS28	RGS18_HUMAN	regulator of G-protein signaling 18	62					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity	p.R62H(1)		kidney(1)|large_intestine(2)|lung(15)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GAAGACACCCGCTCCAGTAGA	0.353000													8	21					0	0	0.307466	0	0
LOC286059	286059	broad.mit.edu	37	8	22938937	22938937	+	RNA	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr8:22938937C>T	ENST00000501897.1	+	0	441					NR_038873.1																						TTTACCTTTTCTCCTACAAAG	0.473000													3	17					0	0	0.307466	0	0
ANKRD9	122416	broad.mit.edu	37	14	102973996	102973996	+	Silent	SNP	G	G	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr14:102973996G>C	ENST00000286918.4	-	4	827	c.231C>G	c.(229-231)ctC>ctG	p.L77L	ANKRD9_ENST00000560748.1_Silent_p.L77L|ANKRD9_ENST00000559651.1_Silent_p.L77L	NM_152326.2	NP_689539.1	Q96BM1	ANKR9_HUMAN	ankyrin repeat domain 9	77										pancreas(1)|skin(1)	2						CGAGCGCGTAGAGCAGCGCCT	0.721000													4	3					0	0	0.150653	0	0
HEG1	57493	broad.mit.edu	37	3	124738166	124738166	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr3:124738166A>G	ENST00000311127.4	-	5	1595	c.1528T>C	c.(1528-1530)Tct>Cct	p.S510P	HEG1_ENST00000477536.1_5'UTR	NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	510	Ser-rich.					extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						GTAGATGAAGACTCTGAATAA	0.463000													5	139					0	0	0.184627	0	0
RPA1	6117	broad.mit.edu	37	17	1782612	1782612	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:1782612C>T	ENST00000254719.5	+	10	973	c.863C>T	c.(862-864)cCc>cTc	p.P288L		NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	288					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						TCCGTCATGCCCTGTGAGGAC	0.443000								Nucleotide excision repair (NER)					26	61					0	0	0.667858	0	0
KIF1A	547	broad.mit.edu	37	2	241706374	241706374	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:241706374C>A	ENST00000498729.2	-	19	1888	c.1642G>T	c.(1642-1644)Gag>Tag	p.E548*	KIF1A_ENST00000320389.7_Nonsense_Mutation_p.E539*	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	539	FHA.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity	p.E539K(1)		NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACGCAGTGCTCCTCCTTGATG	0.652000													7	9					0.000157383	0.000164378	0.278610	1	0
COL6A3	1293	broad.mit.edu	37	2	238287851	238287851	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:238287851A>C	ENST00000295550.4	-	6	2377	c.1925T>G	c.(1924-1926)tTt>tGt	p.F642C	COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000409809.1_Missense_Mutation_p.F436C|COL6A3_ENST00000392003.2_Missense_Mutation_p.F235C|COL6A3_ENST00000392004.3_Missense_Mutation_p.F436C|COL6A3_ENST00000353578.4_Missense_Mutation_p.F436C|COL6A3_ENST00000347401.3_Missense_Mutation_p.F441C|COL6A3_ENST00000346358.4_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	642	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATCCAAAAGAAAGATGATATC	0.393000													26	65					0	0	0.693898	0	0
NUDT21	11051	broad.mit.edu	37	16	56473652	56473652	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr16:56473652C>G	ENST00000300291.5	-	4	560	c.388G>C	c.(388-390)Ggt>Cgt	p.G130R		NM_007006.2	NP_008937.1	O43809	CPSF5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 21	130	Necessary for RNA-binding.|Necessary for interactions with PAPOLA and PABPN1.|Nudix hydrolase.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)	7						TCCTGACGACCCAGTATCTGT	0.403000													86	148					0	0	0.870114	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661272	22661272	+	RNA	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr22:22661272C>T	ENST00000426066.1	+	0	360					NR_027293.1																						CTGGGATGTACGTCTGCGTTG	0.488000													5	64					0	0	0.184627	0	0
DST	667	broad.mit.edu	37	6	56473841	56473841	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr6:56473841C>G	ENST00000370754.5	-	39	5485	c.5486G>C	c.(5485-5487)aGc>aCc	p.S1829T	DST_ENST00000421834.2_Intron|DST_ENST00000312431.6_Missense_Mutation_p.S1651T|DST_ENST00000361203.3_Missense_Mutation_p.S1651T|DST_ENST00000446842.2_Missense_Mutation_p.S1325T|DST_ENST00000244364.6_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000370769.4_Missense_Mutation_p.S1651T			Q03001	DYST_HUMAN	dystonin	1651					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGTTATCATGCTTTGAGCTAG	0.433000													88	226					0	0	0.870114	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427585	71427585	+	Silent	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:71427585T>C	ENST00000373657.1	-	3	1265	c.663A>G	c.(661-663)agA>agG	p.R221R	PIN4_ENST00000423432.2_Intron|ERCC6L_ENST00000334463.3_Silent_p.R344R			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	344	Helicase ATP-binding.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					TTTCATTAAGTCTGGCCTCTG	0.358000													51	185					0	0	0.870114	0	0
COX19	90639	broad.mit.edu	37	7	1009028	1009028	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr7:1009028C>T	ENST00000344111.3	-	3	348	c.259G>A	c.(259-261)Gag>Aag	p.E87K		NM_001031617.2	NP_001026788.1	Q49B96	COX19_HUMAN	cytochrome c oxidase assembly homolog 19 (S. cerevisiae)	87						cytosol				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	5		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;2.15e-15)		TTTTTTGCCTCTGATTTTCCA	0.473000													115	274					0	0	0.870114	0	0
CALHM1	255022	broad.mit.edu	37	10	105215351	105215351	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr10:105215351C>A	ENST00000329905.5	-	2	845	c.709G>T	c.(709-711)Gag>Tag	p.E237*	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	237						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						TTGGCGTGCTCCGTGCACGTC	0.607000													17	28					1.02788e-11	1.13228e-11	0.520397	1	0
ZNF318	24149	broad.mit.edu	37	6	43316104	43316104	+	Silent	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr6:43316104G>A	ENST00000361428.2	-	6	3107	c.3030C>T	c.(3028-3030)agC>agT	p.S1010S	ZNF318_ENST00000318149.3_Silent_p.S1010S	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1010					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTTTTTCTGGGCTCTTAGATT	0.393000													80	183					0	0	0.870114	0	0
MAP3K11	4296	broad.mit.edu	37	11	65380540	65380540	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:65380540G>A	ENST00000309100.3	-	1	1173	c.688C>T	c.(688-690)Cac>Tac	p.H230Y		NM_002419.3	NP_002410.1	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase 11	230	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(14)|skin(1)	24						GCCTCGCAGTGCAGGTAGTGC	0.652000													13	28					0	0	0.411799	0	0
HSPA8	3312	broad.mit.edu	37	11	122930898	122930898	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:122930898T>C	ENST00000534624.1	-	4	766	c.490A>G	c.(490-492)Att>Gtt	p.I164V	HSPA8_ENST00000453788.2_Missense_Mutation_p.I164V|HSPA8_ENST00000227378.3_Missense_Mutation_p.I164V|HSPA8_ENST00000534319.1_5'UTR|HSPA8_ENST00000533540.1_Intron|HSPA8_ENST00000532636.1_Missense_Mutation_p.I164V|HSPA8_ENST00000526862.1_5'UTR|HSPA8_ENST00000526110.1_Missense_Mutation_p.I145V	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	164					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGACCAGCAATAGTTCCAGCA	0.423000													47	72					0	0	0.870114	0	0
CNDP2	55748	broad.mit.edu	37	18	72180800	72180800	+	Nonsense_Mutation	SNP	T	T	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr18:72180800T>A	ENST00000324262.4	+	8	1065	c.749T>A	c.(748-750)tTg>tAg	p.L250*	CNDP2_ENST00000579847.1_Nonsense_Mutation_p.L250*|CNDP2_ENST00000324301.8_Nonsense_Mutation_p.L166*	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	250						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		TCAGGCTCTTTGGTGGACAAG	0.622000													14	27					0	0	0.435327	0	0
NOP16	51491	broad.mit.edu	37	5	175811208	175811208	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:175811208T>C	ENST00000510123.1	-	5	692	c.470A>G	c.(469-471)cAg>cGg	p.Q157R	NOP16_ENST00000507413.1_Missense_Mutation_p.R63G|NOP16_ENST00000389158.5_3'UTR	NM_001256539.1|NM_001256540.1|NM_016391.5	NP_001243468.1|NP_001243469.1|NP_057475.2	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein	0						nucleolus				central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	8						CGCCTCAGCCTGGGGCAGCTG	0.562000													51	45					0	0	0.870114	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981066	61981066	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr20:61981066C>T	ENST00000370263.4	-	5	1918	c.1697G>A	c.(1696-1698)cGg>cAg	p.R566Q	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	566					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CTCCACCGCCCGGGTCAGGGC	0.677000													26	46					0	0	0.681144	0	0
WDR60	55112	broad.mit.edu	37	7	158705779	158705779	+	Missense_Mutation	SNP	T	T	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr7:158705779T>A	ENST00000407559.3	+	13	1852	c.1694T>A	c.(1693-1695)gTa>gAa	p.V565E		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	565										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		AGTACTGTTGTATCTGGAGGT	0.388000													10	23					0	0	0.361761	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113181276	113181276	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr13:113181276G>A	ENST00000261965.3	-	13	1721	c.1535C>T	c.(1534-1536)tCt>tTt	p.S512F	TUBGCP3_ENST00000462580.1_5'UTR|TUBGCP3_ENST00000375669.3_Missense_Mutation_p.S512F	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	512					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					TGACTCTGCAGACTTGGTCAC	0.428000													32	49					0	0	0.804634	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125555791	125555791	+	Silent	SNP	C	C	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:125555791C>G	ENST00000431078.1	+	19	3472	c.3108C>G	c.(3106-3108)tcC>tcG	p.S1036S		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1036	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CAGCTCCATCCAAGGAAAACA	0.448000													19	29					0	0	0.592651	0	0
CUBN	8029	broad.mit.edu	37	10	17165680	17165680	+	Silent	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr10:17165680G>A	ENST00000377833.4	-	5	461	c.396C>T	c.(394-396)gaC>gaT	p.D132D	CUBN_ENST00000377823.1_Silent_p.D132D	NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	132	EGF-like 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAACCTTTTTGTCAACAGTCT	0.448000													6	17					0	0	0.217242	0	0
MYRF	745	broad.mit.edu	37	11	61549236	61549236	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:61549236C>T	ENST00000278836.5	+	22	3052	c.2956C>T	c.(2956-2958)Cga>Tga	p.R986*	TMEM258_ENST00000535042.1_Intron|MYRF_ENST00000389602.4_Nonsense_Mutation_p.R377*|MYRF_ENST00000265460.5_Nonsense_Mutation_p.R951*	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		CCGGGCCCGCCGAGGGGCCCT	0.692000													17	25					0	0	0.557998	0	0
KLK3	354	broad.mit.edu	37	19	51362828	51362828	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr19:51362828A>C	ENST00000360617.3	+	5	673	c.673A>C	c.(673-675)Atg>Ctg	p.M225L	KLK3_ENST00000326003.2_Intron|KLK3_ENST00000595952.1_Intron|KLK3_ENST00000597483.1_Missense_Mutation_p.M182L			P07288	KLK3_HUMAN	kallikrein-related peptidase 3	5	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		AGCCCTGCCGATGGTCCTCCA	0.607000													4	89					0	0	0.184627	0	0
MAPT	4137	broad.mit.edu	37	17	44091681	44091681	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:44091681C>T	ENST00000344290.5	+	13	2315	c.1993C>T	c.(1993-1995)Cat>Tat	p.H665Y	MAPT_ENST00000570299.1_Intron|MAPT_ENST00000576518.1_Missense_Mutation_p.H230Y|MAPT_ENST00000574436.1_Missense_Mutation_p.H330Y|MAPT_ENST00000415613.2_Missense_Mutation_p.H665Y|MAPT_ENST00000351559.5_Missense_Mutation_p.H330Y|MAPT_ENST00000334239.8_Missense_Mutation_p.H241Y|MAPT_ENST00000262410.5_Missense_Mutation_p.H647Y|MAPT_ENST00000446361.3_Missense_Mutation_p.H272Y|MAPT_ENST00000347967.5_Missense_Mutation_p.H205Y|MAPT_ENST00000420682.2_Missense_Mutation_p.H301Y|MAPT_ENST00000535772.1_Missense_Mutation_p.H299Y|MAPT_ENST00000431008.3_Missense_Mutation_p.H299Y|MAPT_ENST00000571987.1_Missense_Mutation_p.H647Y|MAPT_ENST00000340799.5_Missense_Mutation_p.H301Y	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	647					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CAACATCCATCATAAACCAGG	0.552000													13	21					0	0	0.457914	0	0
MYO7A	4647	broad.mit.edu	37	11	76909563	76909563	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:76909563G>A	ENST00000409709.3	+	34	4737	c.4465G>A	c.(4465-4467)Gtc>Atc	p.V1489I	MYO7A_ENST00000458637.2_Missense_Mutation_p.V1489I|MYO7A_ENST00000409619.2_Missense_Mutation_p.V1478I	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1489	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CAAGAACGACGTCATCGTGGC	0.607000													16	35					0	0	0.500413	0	0
CIITA	4261	broad.mit.edu	37	16	10997754	10997754	+	Splice_Site	SNP	T	T	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr16:10997754T>A	ENST00000324288.8	+	9	1070		c.e9+2		CIITA_ENST00000537380.1_Splice_Site|CIITA_ENST00000381835.5_Splice_Site	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator						interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						ACATGACAGGTAAGGACCCTT	0.582000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								34	73					0	0	0.769981	0	0
RUSC1-AS1	284618	broad.mit.edu	37	1	155290484	155290484	+	RNA	SNP	G	G	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:155290484G>C	ENST00000446880.1	-	0	410				RUSC1-AS1_ENST00000543656.1_RNA|RUSC1-AS1_ENST00000443642.1_RNA|RUSC1-AS1_ENST00000450199.1_RNA			Q66K80	RUAS1_HUMAN																			GCTCGGCCCAGCCAGAGTCTG	0.537000													5	14					0	0	0.184627	0	0
SLC22A9	114571	broad.mit.edu	37	11	63177323	63177323	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:63177323A>G	ENST00000279178.3	+	10	1900	c.1651A>G	c.(1651-1653)Acg>Gcg	p.T551A	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	551					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AGTGGAAGTGACGCAGTTTTA	0.398000													9	38					0	0	0.387290	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272785	81272785	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr10:81272785A>G	ENST00000520547.2	+	1	429	c.380A>G	c.(379-381)tAc>tGc	p.Y127C		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	127					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GAGCAGAAGTACGACTGTGGA	0.552000													31	47					0	0	0.796494	0	0
HAAO	23498	broad.mit.edu	37	2	43010461	43010461	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:43010461C>T	ENST00000294973.6	-	4	398	c.343G>A	c.(343-345)Ggg>Agg	p.G115R		NM_012205.2	NP_036337.2	P46952	3HAO_HUMAN	3-hydroxyanthranilate 3,4-dioxygenase	115	Domain A (catalytic) (By similarity).				neuron homeostasis|pyridine nucleotide biosynthetic process|quinolinate biosynthetic process|response to cadmium ion|response to zinc ion|tryptophan catabolic process	cytosol|soluble fraction	3-hydroxyanthranilate 3,4-dioxygenase activity|electron carrier activity|ferrous iron binding			breast(2)|cervix(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(2)	11						TACCTGAGCCCATCTAGCTCG	0.582000													3	21					0	0	0.115264	0	0
ZNF692	55657	broad.mit.edu	37	1	249151460	249151460	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:249151460C>T	ENST00000451251.1	-	4	808	c.463G>A	c.(463-465)Gag>Aag	p.E155K	ZNF692_ENST00000366469.5_Missense_Mutation_p.E150K|ZNF692_ENST00000427146.1_Missense_Mutation_p.E150K|ZNF692_ENST00000306601.4_Missense_Mutation_p.E150K|ZNF692_ENST00000468455.1_5'UTR|ZNF692_ENST00000366471.3_Missense_Mutation_p.E150K	NM_001136036.2	NP_001129508.1	Q9BU19	ZN692_HUMAN	zinc finger protein 692	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CTCGTGGCCTCGGAACACCAA	0.537000													41	61					0	0	0.834066	0	0
RBM22	55696	broad.mit.edu	37	5	150071443	150071443	+	Splice_Site	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:150071443C>A	ENST00000199814.4	-	11	1254	c.1132_splice	c.e11-1	p.G378_splice	RBM22_ENST00000540000.1_Splice_Site_p.G329_splice|RBM22_ENST00000447771.2_Splice_Site_p.G329_splice	NM_018047.2	NP_060517.1	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	378	Pro-rich.				protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(1)	17		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGCCCAAAACCTGCAGATAC	0.483000													39	50					4.92203e-23	5.73558e-23	0.819951	1	0
PDZRN4	29951	broad.mit.edu	37	12	41967638	41967638	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:41967638G>C	ENST00000298919.7	+	10	2665	c.2277G>C	c.(2275-2277)aaG>aaC	p.K759N	PDZRN4_ENST00000539469.2_Missense_Mutation_p.K761N|PDZRN4_ENST00000402685.2_Missense_Mutation_p.K1019N			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	1019							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				ATGGGGCCAAGTCTCCAGATG	0.428000													12	41					0	0	0.435327	0	0
NPIPB6	728741	broad.mit.edu	37	16	28354353	28354353	+	Missense_Mutation	SNP	T	T	G	rs1794256	by1000genomes	TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr16:28354353T>G	ENST00000532254.1	-	7	1538	c.853A>C	c.(853-855)Act>Cct	p.T285P	NPIPB6_ENST00000533640.1_Missense_Mutation_p.T267P					nuclear pore complex interacting protein family, member B6									p.T285P(4)									AGACACTCAGTAGGTGTCTTG	0.507000													3	26					0	0	0.184627	0	0
RTN1	6252	broad.mit.edu	37	14	60069841	60069841	+	Splice_Site	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr14:60069841C>A	ENST00000267484.5	-	8	2565	c.2229_splice	c.e8-1	p.A744_splice	RTN1_ENST00000557422.1_5'UTR|RTN1_ENST00000395090.1_Splice_Site_p.A161_splice|RTN1_ENST00000342503.4_Splice_Site_p.A176_splice	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	744	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TCAATCTGTGCCTACATAAAG	0.363000													17	24					0.000422831	0.000438377	0.500413	1	0
ATP6V0A2	23545	broad.mit.edu	37	12	124218515	124218515	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:124218515G>C	ENST00000330342.3	+	7	939	c.691G>C	c.(691-693)Gga>Cga	p.G231R		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	231					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		ATCCTTTTGGGGAGAGCAGAT	0.328000													38	95					0	0	0.859065	0	0
OR2J2	26707	broad.mit.edu	37	6	29141716	29141716	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr6:29141716C>A	ENST00000377167.2	+	1	406	c.304C>A	c.(304-306)Ctt>Att	p.L102I		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CATGGTTCAACTTTACTTTGT	0.473000													13	179					4.26978e-12	4.77808e-12	0.654019	1	0
SEPHS2	22928	broad.mit.edu	37	16	30455759	30455759	+	Silent	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr16:30455759G>T	ENST00000478753.2	-	1	1743	c.1290C>A	c.(1288-1290)gcC>gcA	p.A430A	SEPHS2_ENST00000542752.1_Silent_p.A373A|SEPHS2_ENST00000500504.2_Silent_p.A430A			Q99611	SPS2_HUMAN	selenophosphate synthetase 2	430					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(3)|cervix(1)|kidney(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	10						CAGCAGCTGTGGCCCCACGAG	0.527000													18	40					5.26018e-13	5.93348e-13	0.608945	1	0
CNKSR2	22866	broad.mit.edu	37	X	21519646	21519646	+	Silent	SNP	A	A	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:21519646A>C	ENST00000425654.2	+	8	1230	c.750A>C	c.(748-750)gcA>gcC	p.A250A	CNKSR2_ENST00000379510.3_Silent_p.A250A|CNKSR2_ENST00000279451.4_Silent_p.A250A|CNKSR2_ENST00000543067.1_Silent_p.A250A	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	250	PDZ.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AGTCACCTGCAGATCGGTGCA	0.343000													10	28					0	0	0.411799	0	0
HUWE1	10075	broad.mit.edu	37	X	53563622	53563622	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:53563622T>C	ENST00000342160.3	-	78	12601	c.12144A>G	c.(12142-12144)atA>atG	p.I4048M	HUWE1_ENST00000262854.6_Missense_Mutation_p.I4048M			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4048	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTTCAAATACTATATACCTGC	0.463000													6	32					0	0	0.248553	0	0
HTATIP2	10553	broad.mit.edu	37	11	20403771	20403771	+	Silent	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:20403771T>C	ENST00000451739.2	+	4	930	c.489T>C	c.(487-489)tcT>tcC	p.S163S	HTATIP2_ENST00000443524.2_Silent_p.S163S|HTATIP2_ENST00000531058.1_Silent_p.S117S|HTATIP2_ENST00000419348.2_Silent_p.S197S|HTATIP2_ENST00000421577.2_Silent_p.S163S	NM_001098522.1	NP_001091992.1	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa	163					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity			large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						ATCGTTACTCTGTATTTAGGC	0.358000													21	39					0	0	0.654019	0	0
DAK	26007	broad.mit.edu	37	11	61109346	61109346	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:61109346C>A	ENST00000394900.3	+	7	846	c.617C>A	c.(616-618)aCc>aAc	p.T206N		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	206	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						TCCAAACCCACCTTCGAGCTC	0.592000													39	89					1.49673e-21	1.71577e-21	0.819951	1	0
CHID1	66005	broad.mit.edu	37	11	870149	870149	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:870149C>G	ENST00000449825.1	-	12	1411	c.1055G>C	c.(1054-1056)aGg>aCg	p.R352T	CHID1_ENST00000528581.1_Missense_Mutation_p.R377T|CHID1_ENST00000323541.7_Missense_Mutation_p.R382T|CHID1_ENST00000436108.2_Missense_Mutation_p.R352T|CHID1_ENST00000429789.2_Missense_Mutation_p.R321T|CHID1_ENST00000336845.5_Missense_Mutation_p.R377T|CHID1_ENST00000323578.8_Missense_Mutation_p.R352T|CHID1_ENST00000454838.2_Missense_Mutation_p.R377T	NM_001142675.1	NP_001136147.1	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1	352					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		GACGACGTGCCTCCCACTGCG	0.667000													21	90					0	0	0.608945	0	0
DNAH2	146754	broad.mit.edu	37	17	7721011	7721011	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:7721011G>A	ENST00000572933.1	+	66	11613	c.10153G>A	c.(10153-10155)Gtc>Atc	p.V3385I	DNAH2_ENST00000389173.2_Missense_Mutation_p.V3385I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3385	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGGCATCATCGTCACCCGAGG	0.597000													10	89					0	0	0.361761	0	0
DDX31	64794	broad.mit.edu	37	9	135535153	135535153	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr9:135535153C>G	ENST00000372159.3	-	5	933	c.782G>C	c.(781-783)aGt>aCt	p.S261T	DDX31_ENST00000438527.3_Missense_Mutation_p.S132T|DDX31_ENST00000372153.1_Missense_Mutation_p.S261T|DDX31_ENST00000480876.1_5'UTR|DDX31_ENST00000310532.2_Missense_Mutation_p.S261T	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	261						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		CACAGGAATACTTTGCTTCTG	0.488000													6	13					0	0	0.217242	0	0
TENM1	10178	broad.mit.edu	37	X	123517773	123517773	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:123517773G>T	ENST00000422452.2	-	30	7071	c.7008C>A	c.(7006-7008)agC>agA	p.S2336R	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.S2329R	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CCTGACCTCGGCTGCTGAACA	0.433000													41	65					2.35958e-20	2.68308e-20	0.847076	1	0
CROCCP2	84809	broad.mit.edu	37	1	16959698	16959698	+	RNA	SNP	G	G	A	rs9730434	by1000genomes	TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:16959698G>A	ENST00000412962.1	-	0	74																		p.H56H(4)									GGTCCTTCTCGTGGAGCACCT	0.657000													5	44					0	0	0.184627	0	0
WDR5	11091	broad.mit.edu	37	9	137007499	137007499	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr9:137007499T>G	ENST00000358625.3	+	6	570	c.399T>G	c.(397-399)ttT>ttG	p.F133L	WDR5_ENST00000425041.1_Missense_Mutation_p.F133L	NM_017588.2	NP_060058.1	P61964	WDR5_HUMAN	WD repeat domain 5	133		Important for interaction with histone H3.			histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		ATTATGTCTTTTGCTGCAACT	0.473000													22	57					0	0	0.654019	0	0
WASH6P	653440	broad.mit.edu	37	X	155254706	155254706	+	RNA	SNP	C	C	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:155254706C>T	ENST00000285718.7	+	0	1151				WASH6P_ENST00000461007.1_RNA														p.T415M(2)									GTGAGAGCCACGAGCCAAGGT	0.637000													4	6					0	0	0.150653	0	0
ADAM20	8748	broad.mit.edu	37	14	70991488	70991488	+	Missense_Mutation	SNP	T	T	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr14:70991488T>G	ENST00000256389.3	-	2	381	c.137A>C	c.(136-138)aAt>aCt	p.N46T	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	0					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GAAGCTGTCATTATGGAGCCA	0.527000													41	62					0	0	0.834066	0	0
COL1A2	1278	broad.mit.edu	37	7	94029506	94029506	+	Splice_Site	SNP	A	A	T	rs113180440		TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr7:94029506A>T	ENST00000297268.6	+	5	603		c.e5-1			NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2						axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTTACATAACAGGGTCCACCA	0.532000										HNSCC(75;0.22)			42	90					0	0	0.859065	0	0
MT-ND4	4538	broad.mit.edu	37	MT	12005	12005	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrM:12005T>C	ENST00000361381.2	+	1	1246	c.1246T>C	c.(1246-1248)Tgg>Cgg	p.416_416insR						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CCACAACACAATGGGGCTCAC	0.443000													2	0					0	0	0.115264	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													4	101					0	0	0.150653	0	0
MTA3	57504	broad.mit.edu	37	2	42924943	42924943	+	Missense_Mutation	SNP	A	A	T			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr2:42924943A>T	ENST00000405592.1	+	12	1496	c.826A>T	c.(826-828)Agt>Tgt	p.S276C	MTA3_ENST00000405094.1_Missense_Mutation_p.S332C|MTA3_ENST00000407270.3_Missense_Mutation_p.S332C|MTA3_ENST00000406652.1_Missense_Mutation_p.S276C|MTA3_ENST00000406911.1_Missense_Mutation_p.S332C|MTA3_ENST00000472767.1_3'UTR			Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	332	SANT.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(9)|ovary(2)|stomach(1)	15						AGAAGCTGAGAGTAAACTGAA	0.264000													5	7					0	0	0.184627	0	0
SNHG12	85028	broad.mit.edu	37	1	28906820	28906820	+	RNA	DEL	A	A	-	rs11325748		TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:28906820delA	ENST00000488745.1	-	0	1100				SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000483436.1_RNA																							actccgtctcaaaaaaaaaaa	0.493													3	3	---	---	---	---					
DUSP12	11266	broad.mit.edu	37	1	161722158	161722158	+	Splice_Site	DEL	A	A	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr1:161722158delA	ENST00000367943.4	+	4	610	c.577_splice	c.e4-1	p.E193_splice	DUSP12_ENST00000484291.1_3'UTR	NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	193					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TGTCATATAGAATTGCAGAAT	0.338													36	100	---	---	---	---					
PBRM1	55193	broad.mit.edu	37	3	52651547	52651548	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr3:52651547_52651548delTC	ENST00000356770.4	-	13	1454_1455	c.1452_1453delGA	c.(1450-1455)aaacfs	p.KN484fs	PBRM1_ENST00000394830.3_Frame_Shift_Del_p.KN516fs|PBRM1_ENST00000296302.7_Frame_Shift_Del_p.KN516fs|PBRM1_ENST00000409767.1_Frame_Shift_Del_p.KN531fs|PBRM1_ENST00000337303.4_Frame_Shift_Del_p.KN516fs|PBRM1_ENST00000410007.1_Frame_Shift_Del_p.KN516fs|PBRM1_ENST00000409114.3_Frame_Shift_Del_p.KN531fs|PBRM1_ENST00000409057.1_Frame_Shift_Del_p.KN516fs			Q86U86	PB1_HUMAN	polybromo 1	516					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TTTCTTATGTTCTTTTTACTGT	0.351			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								30	23	---	---	---	---					
TFRC	7037	broad.mit.edu	37	3	195794940	195794941	+	In_Frame_Ins	INS	-	-	ATT			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr3:195794940_195794941insATT	ENST00000360110.4	-	8	1031_1032	c.862_863insAAT	c.(862-864)tcc>AATtcc	p.287_288insN	TFRC_ENST00000535031.1_In_Frame_Ins_p.5_6insN|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000420415.1_In_Frame_Ins_p.206_207insN|TFRC_ENST00000392396.3_In_Frame_Ins_p.287_288insN	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	287	PA.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AACAATGGGAAATTTAGTCTGG	0.347			T	BCL6	NHL								59	35	---	---	---	---					
TAPT1-AS1	202020	broad.mit.edu	37	4	16257878	16257878	+	RNA	DEL	A	A	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr4:16257878delA	ENST00000570786.1	+	0	234				TAPT1-AS1_ENST00000573308.1_RNA|TAPT1-AS1_ENST00000573950.1_RNA	NR_027696.1																						TTTTTTTTTTAGGTTTTCACT	0.378													2	4	---	---	---	---					
RASGRF2	5924	broad.mit.edu	37	5	80381640	80381640	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:80381640delC	ENST00000265080.4	+	8	1248	c.1181delC	c.(1180-1182)aafs	p.T394fs	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	394	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TATATCATCACACTCCATGAG	0.502													32	103	---	---	---	---					
MCTP1	79772	broad.mit.edu	37	5	94207041	94207041	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:94207041delT	ENST00000515393.1	-	14	2117	c.2118delA	c.(2116-2118)aafs	p.K706fs	MCTP1_ENST00000505078.1_Frame_Shift_Del_p.K222fs|MCTP1_ENST00000429576.2_Frame_Shift_Del_p.K439fs|MCTP1_ENST00000312216.8_Frame_Shift_Del_p.K485fs|MCTP1_ENST00000505208.1_Frame_Shift_Del_p.K485fs	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	706	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		GTATAGCAACTTTGCCCAGAA	0.358													34	94	---	---	---	---					
SLC23A1	9963	broad.mit.edu	37	5	138707769	138707769	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:138707769delA	ENST00000353963.3	-	14	1773	c.1735delT	c.(1735-1737)cafs	p.S579fs	SLC23A1_ENST00000348729.3_Frame_Shift_Del_p.S575fs	NM_152685.3	NP_689898.2	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 1	575					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	TGATCTTTTGAACTTGAAGAA	0.398													172	181	---	---	---	---					
TBC1D9B	23061	broad.mit.edu	37	5	179291015	179291015	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr5:179291015delT	ENST00000356834.3	-	22	3223	c.3186delA	c.(3184-3186)ggfs	p.G1062fs	TBC1D9B_ENST00000444477.2_Frame_Shift_Del_p.G203fs|TBC1D9B_ENST00000518085.1_5'UTR|TBC1D9B_ENST00000355235.3_Frame_Shift_Del_p.G1045fs|TBC1D9B_ENST00000519746.1_Frame_Shift_Del_p.G221fs	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	1062						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCCCACCTCTCCGATGCGGA	0.617													49	56	---	---	---	---					
IL20RA	53832	broad.mit.edu	37	6	137322979	137322979	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr6:137322979delG	ENST00000367748.1	-	6	1631	c.1045delC	c.(1045-1047)tgfs	p.L349fs	IL20RA_ENST00000541547.1_Frame_Shift_Del_p.L411fs|IL20RA_ENST00000316649.5_Frame_Shift_Del_p.L460fs			Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha	460						integral to membrane	receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		TCCTGCGCCAGGGGGTCTAAG	0.587													29	98	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100352939	100352939	+	RNA	DEL	A	A	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr7:100352939delA	ENST00000542585.1	+	0	3363				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTCTGTCGGGAGGGCTGTGTC	0.557													62	136	---	---	---	---					
INTS4	92105	broad.mit.edu	37	11	77672030	77672030	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr11:77672030delG	ENST00000534064.1	-	5	660	c.626delC	c.(625-627)cafs	p.P209fs	INTS4_ENST00000529807.1_Frame_Shift_Del_p.P209fs	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	209					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TCTGACACGTGGGTCTTGGTC	0.408													85	179	---	---	---	---					
TENC1	23371	broad.mit.edu	37	12	53452893	53452893	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr12:53452893delC	ENST00000314250.6	+	18	1758	c.1468delC	c.(1468-1470)ccfs	p.P490fs	TENC1_ENST00000314276.3_Frame_Shift_Del_p.P500fs|TENC1_ENST00000451358.1_Frame_Shift_Del_p.P490fs|TENC1_ENST00000552570.1_Frame_Shift_Del_p.P490fs|TENC1_ENST00000546602.1_Frame_Shift_Del_p.P490fs|TENC1_ENST00000379902.3_Frame_Shift_Del_p.P366fs|TENC1_ENST00000549700.1_Frame_Shift_Del_p.P490fs	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	490	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GCAGCGGCCTCCCCGGCAGAC	0.682													17	43	---	---	---	---					
MAX	4149	broad.mit.edu	37	14	65544727	65544727	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr14:65544727delC	ENST00000284165.6	-	4	347	c.199delG	c.(199-201)ccfs	p.A67fs	MAX_ENST00000557746.1_Frame_Shift_Del_p.A58fs|MAX_ENST00000555932.1_Intron|MAX_ENST00000555667.1_Frame_Shift_Del_p.A58fs|MAX_ENST00000358664.4_Frame_Shift_Del_p.A67fs|MAX_ENST00000556443.1_Frame_Shift_Del_p.A58fs|MAX_ENST00000358402.4_Frame_Shift_Del_p.A58fs|MAX_ENST00000555419.1_Frame_Shift_Del_p.A31fs|MAX_ENST00000556979.1_Frame_Shift_Del_p.A67fs|MAX_ENST00000557277.1_5'UTR|MAX_ENST00000341653.2_Intron	NM_145113.1	NP_660088.1	P61244	MAX_HUMAN	MYC associated factor X	67	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		TATTCTGTGGCTTTGTCTAGG	0.493													19	42	---	---	---	---					
YLPM1	56252	broad.mit.edu	37	14	75230946	75230947	+	Frame_Shift_Ins	INS	-	-	C			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr14:75230946_75230947insC	ENST00000325680.7	+	1	878_879	c.754_755insC	c.(754-756)cccfs	p.P252fs	YLPM1_ENST00000552421.1_Frame_Shift_Ins_p.P252fs|YLPM1_ENST00000238571.3_Frame_Shift_Ins_p.P252fs	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ACCACCGTCCGCCCCCCCTGGA	0.579													18	27	---	---	---	---					
MCTP2	55784	broad.mit.edu	37	15	94942208	94942208	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr15:94942208delA	ENST00000357742.4	+	14	1807	c.1807delA	c.(1807-1809)atfs	p.N603fs	MCTP2_ENST00000557742.1_Frame_Shift_Del_p.N191fs|MCTP2_ENST00000451018.3_Frame_Shift_Del_p.N603fs|MCTP2_ENST00000331706.4_Frame_Shift_Del_p.N191fs	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	603					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TGGACAACCGAATTGTTATGT	0.318													29	57	---	---	---	---					
SSH2	85464	broad.mit.edu	37	17	28022532	28022533	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chr17:28022532_28022533insG	ENST00000269033.3	-	4	371_372	c.220_221insC	c.(220-222)acafs	p.T74fs	SSH2_ENST00000540801.1_Frame_Shift_Ins_p.T101fs|SSH2_ENST00000324677.7_5'UTR|RP11-68I3.2_ENST00000581474.1_RNA	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	74					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAGATGCTGTTGGAGATCGCCT	0.376													38	74	---	---	---	---					
THOC2	57187	broad.mit.edu	37	X	122748006	122748007	+	Frame_Shift_Ins	INS	-	-	TGGACAGTGG			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:122748006_122748007insTGGACAGTGG	ENST00000245838.8	-	34	4376_4377	c.4345_4346insCCACTGTCCA	c.(4345-4347)gagfs	p.E1449fs	THOC2_ENST00000464992.1_5'UTR|THOC2_ENST00000491737.1_Frame_Shift_Ins_p.E1334fs|THOC2_ENST00000355725.4_Frame_Shift_Ins_p.E1449fs	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1449	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						CTCCTTACTCTTGGACAGTGGT	0.361													17	158	---	---	---	---					
STAG2	10735	broad.mit.edu	37	X	123200270	123200280	+	Frame_Shift_Del	DEL	AAAGCAGCTCT	AAAGCAGCTCT	-			TCGA-B0-5712-01A-11D-1669-08	TCGA-B0-5712-11A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6bb18fc9-538b-4f01-8fd2-627e55dfd2e4	a8477a84-8b4d-4260-931a-35d03d574e09	g.chrX:123200270_123200280delAAAGCAGCTCT	ENST00000371160.1	+	23	2539_2549	c.2249_2259delAAAGCAGCTCT	c.(2248-2259)gfs	p.ESSS750fs	STAG2_ENST00000354548.5_Frame_Shift_Del_p.ESSS681fs|STAG2_ENST00000371144.3_Frame_Shift_Del_p.ESSS750fs|STAG2_ENST00000371157.3_Frame_Shift_Del_p.ESSS750fs|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000371145.3_Frame_Shift_Del_p.ESSS750fs|STAG2_ENST00000218089.9_Frame_Shift_Del_p.ESSS750fs			Q8N3U4	STAG2_HUMAN	stromal antigen 2	750					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						AAGATAACTGAAAGCAGCTCTACAAAGGTTT	0.327													18	78	---	---	---	---					
