Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr13:115047559C>T	ENST00000375299.3	+	2	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_ENST00000351487.5_Silent_p.L91L	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding	p.L91L(8)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													4	20					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799202	57799202	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr11:57799202T>C	ENST00000302622.3	+	1	801	c.778T>C	c.(778-780)Ttc>Ctc	p.F260L	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				TGGCACTCTTTTCTTTATGTA	0.517000													6	265					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178922340	178922340	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:178922340A>G	ENST00000263967.3	+	6	1266	c.1109A>G	c.(1108-1110)aAt>aGt	p.N370S		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	370	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTATGTGACAATGTGAACACT	0.333000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	292					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204066361	204066361	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr2:204066361C>T	ENST00000449802.1	+	49	7580	c.7247C>T	c.(7246-7248)gCt>gTt	p.A2416V		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2416							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CTCTTCAGTGCTGGATACTGG	0.398000													4	213					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38464075	38464075	+	Missense_Mutation	SNP	G	G	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr5:38464075G>T	ENST00000322350.5	+	22	3363	c.3017G>T	c.(3016-3018)tGt>tTt	p.C1006F	EGFLAM_ENST00000354891.3_Missense_Mutation_p.C1014F|EGFLAM_ENST00000336740.6_Missense_Mutation_p.C772F|EGFLAM_ENST00000397210.3_Missense_Mutation_p.C149F|EGFLAM_ENST00000506135.1_Missense_Mutation_p.C149F|EGFLAM_ENST00000514476.1_Missense_Mutation_p.C149F|CTD-2263F21.1_ENST00000510469.1_RNA|EGFLAM_ENST00000397202.2_Missense_Mutation_p.C372F	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	1014	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					ATCAACACTTGTGGAGCCAAG	0.537000													46	72					3.39706e-21	3.80267e-21	1	1	0
IRX5	10265	broad.mit.edu	37	16	54967008	54967008	+	Silent	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr16:54967008G>A	ENST00000394636.4	+	3	1012	c.675G>A	c.(673-675)gcG>gcA	p.A225A	IRX5_ENST00000320990.5_Silent_p.A224A|IRX5_ENST00000560154.1_Intron|IRX5_ENST00000558597.1_Silent_p.A159A			P78411	IRX5_HUMAN	iroquois homeobox 5	225					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						AGCAGAAGGCGGCTTCGGGCT	0.706000													18	14					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102304896	102304896	+	RNA	SNP	C	C	G	rs145942024	by1000genomes	TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr15:102304896C>G	ENST00000561463.1	+	0	12942																											GAAGACACTCCTGGAGGAGTC	0.562000													4	33					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916876	178916876	+	Missense_Mutation	SNP	G	G	A	rs121913287		TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:178916876G>A	ENST00000263967.3	+	2	420	c.263G>A	c.(262-264)cGa>cAa	p.R88Q		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(53)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAACAAGACGACTTTGTGAC	0.363000	R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SKUT1_SOFT_TISSUE)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			55	117					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89457251	89457251	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:89457251G>A	ENST00000336596.2	+	9	1957	c.1732G>A	c.(1732-1734)Gaa>Aaa	p.E578K	EPHA3_ENST00000494014.1_Missense_Mutation_p.E578K	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	578						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGGGGCAGATGAAAAAAGACT	0.353000										TSP Lung(6;0.00050)			98	164					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24582966	24582966	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr16:24582966G>A	ENST00000319715.4	+	18	5011	c.4579G>A	c.(4579-4581)Gga>Aga	p.G1527R	RBBP6_ENST00000381039.3_Missense_Mutation_p.G687R|RBBP6_ENST00000348022.2_Missense_Mutation_p.G1493R	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1527	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		AAAAGGAACAGGAGATTCCAA	0.373000													32	52					0	0	1	0	0
PPBP	5473	broad.mit.edu	37	4	74853701	74853701	+	Missense_Mutation	SNP	T	T	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr4:74853701T>G	ENST00000296028.3	-	1	213	c.120A>C	c.(118-120)caA>caC	p.Q40H		NM_002704.3	NP_002695.1	P02775	CXCL7_HUMAN	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	40					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			breast(1)|central_nervous_system(1)|lung(1)|ovary(2)|skin(2)|stomach(1)|urinary_tract(2)	10	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			TTCTCTTAGTTTGTCCTTTGG	0.527000													52	73					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56505011	56505011	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr12:56505011A>G	ENST00000303305.6	+	11	1402	c.983A>G	c.(982-984)aAt>aGt	p.N328S	RP11-603J24.17_ENST00000548595.1_RNA|PA2G4_ENST00000552766.1_Intron	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	328	Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			CTCATGCCCAATGGCCCCATG	0.433000													69	165					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237791209	237791209	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr1:237791209G>A	ENST00000366574.2	+	41	6586	c.6269G>A	c.(6268-6270)cGg>cAg	p.R2090Q	RYR2_ENST00000360064.6_Missense_Mutation_p.R2088Q|RYR2_ENST00000542537.1_Missense_Mutation_p.R2074Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2090	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.R2088Q(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGCTCCATCGGCAGTATGAC	0.557000													9	64					0	0	1	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870087	151870087	+	Silent	SNP	G	G	T	rs79585035		TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chrX:151870087G>T	ENST00000329342.5	+	3	1002	c.777G>T	c.(775-777)cgG>cgT	p.R259R		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	259	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					TGGAGTACCGGCAGGTCCCCG	0.522000													182	337					3.86445e-50	4.45898e-50	1	1	0
CCDC60	160777	broad.mit.edu	37	12	119909928	119909928	+	Silent	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr12:119909928C>T	ENST00000327554.2	+	3	765	c.300C>T	c.(298-300)gcC>gcT	p.A100A	RP11-768F21.1_ENST00000509470.2_lincRNA|CCDC60_ENST00000546345.1_3'UTR	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	100										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TCCAGCCAGCCGAAAAGATCT	0.423000													102	249					0	0	1	0	0
MICAL1	64780	broad.mit.edu	37	6	109766001	109766001	+	Splice_Site	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr6:109766001C>T	ENST00000368952.4	-	24	3329	c.3038_splice	c.e24-1	p.T1013_splice	MICAL1_ENST00000358807.3_Splice_Site_p.T994_splice|MICAL1_ENST00000358577.3_Splice_Site_p.T908_splice			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	994					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		ATTCCTGCACCCTGTGGAGGT	0.577000													5	155					0	0	1	0	0
IGHA1	0	broad.mit.edu	37	14	106173865	106173865	+	RNA	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr14:106173865C>T	ENST00000390547.2	-	0	701																											CCGACGGCGGCGGCAGCAGGT	0.682000													4	66					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119046	19119046	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr22:19119046G>A	ENST00000399635.2	+	1	726	c.134G>A	c.(133-135)cGc>cAc	p.R45H	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	45	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					ATCATCGACCGCAAGAAAACA	0.488000													4	132					0	0	1	0	0
IGHA2	0	broad.mit.edu	37	14	106053634	106053634	+	RNA	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr14:106053634C>T	ENST00000390539.2	-	0	662																											CCGACGGCGGCGGCAGCAGGT	0.677000													13	32					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25487066	25487066	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr13:25487066C>T	ENST00000381884.4	-	2	283	c.98G>A	c.(97-99)cGt>cAt	p.R33H	CENPJ_ENST00000545981.1_Missense_Mutation_p.R33H	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	33					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		AGGAAATCCACGATTTAATAT	0.448000													4	162					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131222116	131222116	+	Silent	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr6:131222116C>T	ENST00000337057.3	-	7	1315	c.1134G>A	c.(1132-1134)ctG>ctA	p.L378L	EPB41L2_ENST00000527659.1_Silent_p.L378L|EPB41L2_ENST00000530148.1_5'UTR|EPB41L2_ENST00000527411.1_Silent_p.L378L|EPB41L2_ENST00000528282.1_Silent_p.L378L|EPB41L2_ENST00000445890.2_Silent_p.L378L|EPB41L2_ENST00000525271.1_Silent_p.L378L|EPB41L2_ENST00000529208.1_Silent_p.L378L|EPB41L2_ENST00000530481.1_Silent_p.L378L|EPB41L2_ENST00000392427.3_Silent_p.L378L|EPB41L2_ENST00000525193.1_Silent_p.L378L|EPB41L2_ENST00000368128.2_Silent_p.L378L	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	378	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		GGGTTTTGTGCAGCTCTGCCA	0.473000													6	367					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139907686	139907686	+	Silent	SNP	G	G	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr9:139907686G>T	ENST00000265662.5	-	30	4782	c.4635C>A	c.(4633-4635)ctC>ctA	p.L1545L	ABCA2_ENST00000341511.6_Silent_p.L1545L|ABCA2_ENST00000371605.3_Silent_p.L1544L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1544					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGGAGACTTGAGCACGCAGG	0.701000													3	32					1	1	1	1	0
NLRC4	58484	broad.mit.edu	37	2	32476399	32476399	+	Silent	SNP	C	C	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr2:32476399C>A	ENST00000404025.2	-	5	1022	c.534G>T	c.(532-534)ctG>ctT	p.L178L	NLRC4_ENST00000360906.5_Silent_p.L178L|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Silent_p.L178L			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	178	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTCGCTGCAGCAGAGTGGACT	0.582000													5	126					5.18039e-06	5.55042e-06	1	1	0
GLI2	2736	broad.mit.edu	37	2	121712960	121712960	+	Silent	SNP	C	C	A	rs149502176		TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr2:121712960C>A	ENST00000452319.1	+	5	657	c.597C>A	c.(595-597)ggC>ggA	p.G199G	GLI2_ENST00000361492.4_Silent_p.G199G|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000314490.11_5'UTR			P10070	GLI2_HUMAN	GLI family zinc finger 2	199					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				AGAGCGGGGGCGCTGCCAGCG	0.667000													17	33					3.41278e-10	3.7641e-10	1	1	0
MUC4	4585	broad.mit.edu	37	3	195511937	195511937	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:195511937C>T	ENST00000463781.3	-	2	6973	c.6514G>A	c.(6514-6516)Ggt>Agt	p.G2172S	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.G2172S|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	951					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGGCGTGACCTGTGGATGCT	0.577000													5	4					0	0	1	0	0
CHRDL1	91851	broad.mit.edu	37	X	109931822	109931822	+	Splice_Site	SNP	C	C	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chrX:109931822C>A	ENST00000218054.4	-	9	1181	c.985_splice	c.e9+1	p.E329_splice	CHRDL1_ENST00000434224.1_Splice_Site_p.E250_splice|CHRDL1_ENST00000394797.4_Splice_Site_p.E329_splice|CHRDL1_ENST00000372042.1_Splice_Site_p.E330_splice|CHRDL1_ENST00000444321.2_Splice_Site_p.E329_splice|CHRDL1_ENST00000372045.1_Splice_Site_p.E323_splice|CHRDL1_ENST00000482160.1_Splice_Site_p.E250_splice	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	323					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						ACCAACGCACCTTTTGCTTTT	0.413000													114	210					7.82854e-59	9.17407e-59	1	1	0
STC2	8614	broad.mit.edu	37	5	172745215	172745215	+	Missense_Mutation	SNP	C	C	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr5:172745215C>A	ENST00000265087.4	-	4	1853	c.544G>T	c.(544-546)Ggg>Tgg	p.G182W	STC2_ENST00000520593.1_5'UTR	NM_003714.2	NP_003705.1	O76061	STC2_HUMAN	stanniocalcin 2	182					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(3)	25	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ACCTCCTCCCCACAGGTCAGC	0.552000													3	55					6.4e-05	6.76056e-05	1	1	0
CPEB4	80315	broad.mit.edu	37	5	173380277	173380277	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr5:173380277T>C	ENST00000519835.1	+	7	2092	c.1889T>C	c.(1888-1890)gTa>gCa	p.V630A	CPEB4_ENST00000265085.5_Splice_Site|CPEB4_ENST00000519467.1_Splice_Site|CPEB4_ENST00000522336.1_Splice_Site|CPEB4_ENST00000334035.5_Splice_Site|CPEB4_ENST00000517880.1_Splice_Site|CPEB4_ENST00000520867.1_Splice_Site			Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	655	RRM 2.						nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GATAAACGGGTAAGCCTTATA	0.403000													60	119					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7668883	7668883	+	Silent	SNP	C	C	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr4:7668883C>A	ENST00000507866.2	+	8	1213	c.1104C>A	c.(1102-1104)gtC>gtA	p.V368V	SORCS2_ENST00000329016.9_Silent_p.V196V	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	368						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						AATACTACGTCTCTTATCGTC	0.483000													46	309					1.89013e-27	2.14787e-27	1	1	0
CIC	23152	broad.mit.edu	37	19	42791757	42791757	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr19:42791757C>T	ENST00000572681.2	+	6	3438	c.3370C>T	c.(3370-3372)Cgg>Tgg	p.R1124W	CIC_ENST00000575354.2_Missense_Mutation_p.R215W|CIC_ENST00000160740.3_Missense_Mutation_p.R215W			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	215	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.R215W(4)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CAAGCGGCACCGGGCCCTGGT	0.612000			"""Mis, F, S"""		oligodendroglioma								47	34					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195516065	195516065	+	Nonsense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:195516065G>A	ENST00000463781.3	-	2	2845	c.2386C>T	c.(2386-2388)Cga>Tga	p.R796*	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Nonsense_Mutation_p.R796*|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	801	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGTGGTTCGTGACCCTGAG	0.602000													69	151					0	0	1	0	0
ARRDC5	645432	broad.mit.edu	37	19	4896810	4896810	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr19:4896810C>T	ENST00000381781.2	-	2	373	c.374G>A	c.(373-375)aGc>aAc	p.S125N		NM_001080523.1	NP_001073992.1	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	125					signal transduction					endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		GCCAAATTTGCTGGTGAAGGT	0.448000													5	196					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								55	130					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113857403	113857403	+	Missense_Mutation	SNP	T	T	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr11:113857403T>G	ENST00000504030.2	+	7	1314	c.869T>G	c.(868-870)aTc>aGc	p.I290S	HTR3A_ENST00000506841.2_Missense_Mutation_p.I290S|HTR3A_ENST00000299961.5_Missense_Mutation_p.I275S|HTR3A_ENST00000375498.2_Missense_Mutation_p.I296S|HTR3A_ENST00000535865.1_Missense_Mutation_p.I34S|HTR3A_ENST00000355556.2_Missense_Mutation_p.I296S			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	290					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TTCCTGATCATCGTTTCTGAC	0.592000													5	171					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49881320	49881320	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:49881320G>A	ENST00000331456.2	-	5	435	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	TRAIP_ENST00000473863.1_5'UTR|TRAIP_ENST00000469027.1_Intron	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	108					cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGCGTATCCCGCAGAGTGTCG	0.562000													5	215					0	0	1	0	0
CPEB2	132864	broad.mit.edu	37	4	15055831	15055831	+	Silent	SNP	T	T	C			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr4:15055831T>C	ENST00000538197.1	+	8	2451	c.2451T>C	c.(2449-2451)ttT>ttC	p.F817F	CPEB2_ENST00000259997.5_Silent_p.F380F|CPEB2_ENST00000541112.1_Silent_p.F809F|CPEB2_ENST00000442003.2_Silent_p.F790F|CPEB2_ENST00000382395.3_Silent_p.F350F|CPEB2_ENST00000507071.1_Silent_p.F372F|CPEB2_ENST00000382401.3_Silent_p.F345F|RP11-665G4.1_ENST00000502344.1_RNA|RP11-665G4.1_ENST00000513384.1_RNA|CPEB2_ENST00000345451.3_Silent_p.F342F	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	372					regulation of translation	cytoplasm	nucleotide binding|RNA binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						AGTCCTATTTTCCACCAAAAG	0.343000													112	203					0	0	1	0	0
ASAH1	427	broad.mit.edu	37	8	17919903	17919903	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr8:17919903A>G	ENST00000262097.6	-	8	844	c.533T>C	c.(532-534)aTa>aCa	p.I178T	ASAH1_ENST00000520781.1_Missense_Mutation_p.I153T|ASAH1_ENST00000314146.10_Missense_Mutation_p.I172T|ASAH1_ENST00000417108.2_Missense_Mutation_p.I88T|ASAH1_ENST00000381733.4_Missense_Mutation_p.I194T	NM_177924.3	NP_808592.2	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase (acid ceramidase) 1	178					ceramide metabolic process	lysosome	ceramidase activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		TTGCTCAGTTATGACCCAGGT	0.373000													71	136					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133886296	133886296	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr7:133886296A>G	ENST00000285928.2	+	15	1880	c.1811A>G	c.(1810-1812)gAg>gGg	p.E604G		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	604							ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						GGATTGACTGAGGAACCTGCC	0.388000													50	85					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161052897	161052897	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr2:161052897C>T	ENST00000283249.2	-	3	413	c.176G>A	c.(175-177)tGt>tAt	p.C59Y	ITGB6_ENST00000428609.2_Missense_Mutation_p.C17Y|ITGB6_ENST00000409872.1_Missense_Mutation_p.C59Y|ITGB6_ENST00000409967.2_Missense_Mutation_p.C59Y|ITGB6_ENST00000485635.1_5'UTR			P18564	ITB6_HUMAN	integrin, beta 6	59					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TGGGGTATCACACCTTTCGCC	0.328000													106	223					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26239776	26239776	+	Missense_Mutation	SNP	C	C	T	rs34356798		TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr22:26239776C>T	ENST00000335473.7	+	18	3533	c.3283C>T	c.(3283-3285)Cgg>Tgg	p.R1095W	MYO18B_ENST00000407587.2_Missense_Mutation_p.R1096W|MYO18B_ENST00000536101.1_Missense_Mutation_p.R1095W	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1095	Myosin head-like.		R -> L (in a lung adenocarcinoma sample; somatic mutation).			nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGACCCTGTGCGGTACGACCT	0.612000													4	178					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	732477	732477	+	Silent	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr9:732477G>A	ENST00000382303.1	+	10	3757	c.3105G>A	c.(3103-3105)gaG>gaA	p.E1035E	KANK1_ENST00000382293.3_Silent_p.E877E|KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382297.2_Silent_p.E1035E	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	1035					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TTGAAGAAGAGGAGGAGGAGG	0.468000													5	251					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79296998	79296998	+	Missense_Mutation	SNP	G	G	C			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr4:79296998G>C	ENST00000264895.6	+	26	3697	c.3257G>C	c.(3256-3258)gGc>gCc	p.G1086A	FRAS1_ENST00000325942.6_Missense_Mutation_p.G1086A	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1085					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGTGTTCCTGGCTTTTCTGTC	0.478000													21	43					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S152S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								6	136					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15882705	15882705	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr21:15882705G>A	ENST00000285670.2	-	6	865	c.691C>T	c.(691-693)Cca>Tca	p.P231S	SAMSN1_ENST00000400564.1_Intron|SAMSN1_ENST00000400566.1_Missense_Mutation_p.P163S	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	163					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CCACAGAATGGTCCTGAATAG	0.502000													15	166					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36932096	36932096	+	Nonsense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr1:36932096C>T	ENST00000373103.1	-	17	3001	c.2454G>A	c.(2452-2454)tgG>tgA	p.W818*	CSF3R_ENST00000361632.4_Nonsense_Mutation_p.W791*|CSF3R_ENST00000440588.2_Nonsense_Mutation_p.W818*|CSF3R_ENST00000373104.1_Intron|CSF3R_ENST00000418048.2_Nonsense_Mutation_p.W791*|CSF3R_ENST00000373106.1_Nonsense_Mutation_p.W791*|CSF3R_ENST00000331941.5_Intron|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000338937.5_Missense_Mutation_p.G760D	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	791					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TGGCCTGGAACCAGAGGTTCT	0.657000													4	23					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864692	153864692	+	Silent	SNP	A	A	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr4:153864692A>G	ENST00000511601.1	+	2	671	c.483A>G	c.(481-483)agA>agG	p.R161R	FHDC1_ENST00000260008.3_Silent_p.R161R			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	161	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					CATCCTTCAGAGAAGCTCGAG	0.428000													51	84					0	0	1	0	0
FAM183B	340286	broad.mit.edu	37	7	38725296	38725296	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr7:38725296G>A	ENST00000409072.3	-	2	1244	c.310C>T	c.(310-312)Cgc>Tgc	p.R104C						family with sequence similarity 183, member B											endometrium(1)|lung(7)	8						TGGTCACGGCGTTCTGGGTCG	0.527000													18	399					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152938703	152938703	+	Missense_Mutation	SNP	C	C	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chrX:152938703C>A	ENST00000370145.4	-	1	40	c.23G>T	c.(22-24)gGc>gTc	p.G8V	PNCK_ENST00000447676.2_Intron|PNCK_ENST00000475172.1_Intron|PNCK_ENST00000340888.3_Intron|PNCK_ENST00000393831.2_Intron|PNCK_ENST00000370142.1_Intron|PNCK_ENST00000370150.1_Intron	NM_001135740.1	NP_001129212.1	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	0						cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCAGCGAGGCCACCGCATAC	0.716000													13	26					1.3612e-06	1.47957e-06	1	1	0
LRP2	4036	broad.mit.edu	37	2	170093674	170093674	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr2:170093674T>C	ENST00000263816.3	-	28	4915	c.4630A>G	c.(4630-4632)Act>Gct	p.T1544A		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1544					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCAGCACAGTCCTGTGGCTC	0.378000													95	156					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100527058	100527058	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:100527058G>A	ENST00000471714.1	-	50	3759	c.3650C>T	c.(3649-3651)gCt>gTt	p.A1217V	ABI3BP_ENST00000383691.4_Missense_Mutation_p.A494V|ABI3BP_ENST00000284322.5_Missense_Mutation_p.A540V			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	540						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						CTTAGGAGGAGCACGTGGTGT	0.428000													17	32					0	0	1	0	0
CDC37	11140	broad.mit.edu	37	19	10505756	10505756	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr19:10505756C>T	ENST00000222005.2	-	5	720	c.667G>A	c.(667-669)Gcc>Acc	p.A223T		NM_007065.3	NP_008996.1	Q16543	CDC37_HUMAN	cell division cycle 37	223					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	16			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		AGGCTCTTGGCCAGCTCCAGG	0.592000													4	174					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319252	21319252	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr17:21319252G>A	ENST00000583088.1	+	3	1493	c.598G>A	c.(598-600)Gcc>Acc	p.A200T	KCNJ12_ENST00000331718.5_Missense_Mutation_p.A200T	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CAGCCACAACGCCGTGGTGGC	0.612000										Prostate(3;0.18)			18	101					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150916431	150916431	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr1:150916431A>G	ENST00000271640.5	+	8	1101	c.911A>G	c.(910-912)tAt>tGt	p.Y304C	SETDB1_ENST00000368962.2_Missense_Mutation_p.Y304C|SETDB1_ENST00000368963.1_Missense_Mutation_p.237_237insV|SETDB1_ENST00000459773.1_Intron|SETDB1_ENST00000368969.4_Missense_Mutation_p.Y304C	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	304	Tudor 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding	p.Y304C(1)		NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATGCTTCCTATGTCACACAG	0.408000													68	128					0	0	1	0	0
SRSF3	6428	broad.mit.edu	37	6	36564571	36564571	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr6:36564571A>G	ENST00000373715.6	+	2	148	c.32A>G	c.(31-33)aAg>aGg	p.K11R	SRSF3_ENST00000339436.7_Missense_Mutation_p.K11R	NM_003017.4	NP_003008.1	P84103	SRSF3_HUMAN	serine/arginine-rich splicing factor 3	11	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(2)	7						TTGGACTGTAAGGTTTATGTA	0.398000													123	230					0	0	1	0	0
PRELP	5549	broad.mit.edu	37	1	203452722	203452722	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr1:203452722G>A	ENST00000343110.2	+	2	537	c.410G>A	c.(409-411)cGa>cAa	p.R137Q		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	137					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			GACAACAACCGAATCCGCAAG	0.552000													4	174					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752635	62752635	+	RNA	SNP	G	G	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr7:62752635G>T	ENST00000331425.6	-	0	800					NR_003952.1																						GCGCCTAAAGGCTTGGCCACA	0.458000													5	142					0.0293803	0.0297774	1	1	0
TIMD4	91937	broad.mit.edu	37	5	156378598	156378598	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr5:156378598G>A	ENST00000274532.2	-	3	660	c.604C>T	c.(604-606)Cca>Tca	p.P202S	TIMD4_ENST00000407087.3_Missense_Mutation_p.P202S	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	202	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGGTGCTTGGGGTTAGTGAA	0.537000													64	133					0	0	1	0	0
XIST	0	broad.mit.edu	37	X	73063859	73063859	+	RNA	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chrX:73063859G>A	ENST00000429829.1	-	0	8729					NR_001564.2																						AGAAGTGATAGGGTTGTGGAC	0.413000													32	60					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156784873	156784873	+	Silent	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr1:156784873C>T	ENST00000392306.2	-	3	403	c.264G>A	c.(262-264)caG>caA	p.Q88Q	SH2D2A_ENST00000495306.1_5'UTR|SH2D2A_ENST00000368199.3_Silent_p.Q88Q|SH2D2A_ENST00000368198.3_Silent_p.Q70Q	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	88					angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGCCCCGTGCTGCAGGAGCC	0.642000													3	39					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151164884	151164884	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr3:151164884C>T	ENST00000282466.3	-	4	2884	c.2885G>A	c.(2884-2886)aGt>aAt	p.S962N		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	962					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCTGGGTTCACTCACTTCTCT	0.408000													82	173					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100779027	100779027	+	Silent	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr7:100779027G>A	ENST00000223095.4	+	7	1189	c.1032G>A	c.(1030-1032)ctG>ctA	p.L344L	SERPINE1_ENST00000445463.2_Silent_p.L329L	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	344					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	CGCAGGCGCTGCAGAAAGTGA	0.572000													4	147					0	0	1	0	0
TRMT6	51605	broad.mit.edu	37	20	5927167	5927167	+	Silent	SNP	G	G	A			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr20:5927167G>A	ENST00000203001.2	-	2	271	c.141C>T	c.(139-141)ttC>ttT	p.F47F	TRMT6_ENST00000473131.1_5'UTR|TRMT6_ENST00000453074.2_5'UTR	NM_015939.3	NP_057023.2	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6 homolog (S. cerevisiae)	47					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	15						ACTGTTTTTCGAAAGTTACTT	0.373000													43	80					0	0	1	0	0
RP11-782C8.2	0	broad.mit.edu	37	1	143189585	143189587	+	RNA	DEL	TAA	TAA	-			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr1:143189585_143189587delTAA	ENST00000412204.2	-	0	2449				RP11-782C8.3_ENST00000425124.1_lincRNA|RP11-782C8.1_ENST00000438000.1_lincRNA																							TTATCAGAGTTAATAAGAACGAG	0.251													5	11	---	---	---	---					
SORBS2	8470	broad.mit.edu	37	4	186559269	186559269	+	Frame_Shift_Del	DEL	C	C	-			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr4:186559269delC	ENST00000393528.3	-	12	1607	c.870delG	c.(868-870)tgfs	p.W290fs	SORBS2_ENST00000355634.5_Intron|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000284776.7_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000431808.1_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000418609.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000437304.2_Intron	NM_003603.5	NP_003594.3	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	228						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGAATTTATACCAGGGCTCAT	0.383													92	187	---	---	---	---					
ZMIZ1	57178	broad.mit.edu	37	10	81070787	81070789	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr10:81070787_81070789delCTC	ENST00000334512.5	+	24	3514_3516	c.2942_2944delCTC	c.(2941-2946)gct>g	p.AP981del	ZMIZ1_ENST00000446377.2_Intron	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	981	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CACAGTGGGGCTCCTCCTCCTCC	0.635													7	324	---	---	---	---					
IRX5	10265	broad.mit.edu	37	16	54967130	54967131	+	Frame_Shift_Ins	INS	-	-	C			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr16:54967130_54967131insC	ENST00000394636.4	+	3	1134_1135	c.797_798insC	c.(796-798)gccfs	p.A266fs	IRX5_ENST00000320990.5_Frame_Shift_Ins_p.A265fs|IRX5_ENST00000560154.1_Intron|IRX5_ENST00000558597.1_Frame_Shift_Ins_p.A200fs			P78411	IRX5_HUMAN	iroquois homeobox 5	266					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						GCGCTGCAgggccccccccgca	0.792													2	4	---	---	---	---					
ZFPM1	161882	broad.mit.edu	37	16	88600445	88600445	+	Frame_Shift_Del	DEL	C	C	-			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chr16:88600445delC	ENST00000319555.3	+	10	2401	c.2079delC	c.(2077-2079)agfs	p.S693fs		NM_153813.2	NP_722520.2	Q8IX07	FOG1_HUMAN	zinc finger protein, FOG family member 1	693					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)|ovary(2)|urinary_tract(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TCCGCTTCAGCCGCCACGAGA	0.761													2	4	---	---	---	---					
SLC9B1P1	0	broad.mit.edu	37	Y	13501672	13501674	+	In_Frame_Del	DEL	AAT	AAT	-			TCGA-R8-A6MO-01A-11D-A33T-08	TCGA-R8-A6MO-10C-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b826e5b4-3335-4b3c-a545-dd13a17acb2b	17ee5ee3-a2a0-4756-84ce-f1190b597115	g.chrY:13501672_13501674delAAT	ENST00000331172.6	-	4	534_536	c.535_537delATT	c.(535-537)del	p.I179del																								TCTTACCAACAATATTTGATTCA	0.241													5	8	---	---	---	---					
