Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
XPO5	57510	broad.mit.edu	37	6	43496612	43496612	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:43496612G>T	ENST00000265351.7	-	24	2939	c.2729C>A	c.(2728-2730)gCc>gAc	p.A910D	POLR1C_ENST00000304004.3_Intron	NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	910					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			GGATACCAGGGCTTCATAGTG	0.478000													4	45					2.56e-06	2.61525e-06	1	1	0
SPTBN5	51332	broad.mit.edu	37	15	42180130	42180130	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr15:42180130G>C	ENST00000320955.6	-	5	882	c.655C>G	c.(655-657)Cac>Gac	p.H219D		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	219	Actin-binding.|CH 2.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TCACACCTGTGGGCATGGATG	0.602000													7	22					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42438416	42438416	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr15:42438416G>A	ENST00000397272.3	-	14	1540	c.1449C>T	c.(1447-1449)gaC>gaT	p.D483D	PLA2G4F_ENST00000382396.4_Silent_p.D481D	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	481	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CCTCCTGTTGGTCAGACAGCT	0.612000													5	104					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235950608	235950608	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:235950608T>C	ENST00000389794.3	-	14	4928	c.4754A>G	c.(4753-4755)aAt>aGt	p.N1585S	LYST_ENST00000536965.1_3'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.N1585S			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1585					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GAGGAAAATATTCTCCTGTGA	0.413000													17	343					0	0	1	0	0
SPRY3	10251	broad.mit.edu	37	X	155004315	155004315	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:155004315G>A	ENST00000302805.2	+	2	1213	c.782G>A	c.(781-783)cGc>cAc	p.R261H		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	261	Cys-rich.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCAGGCTGCCGCTGCAAGAGG	0.572000													23	315					0	0	1	0	0
CYSLTR1	0	broad.mit.edu	37	X	77528954	77528954	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:77528954C>T	ENST00000373304.3	-	3	582	c.290G>A	c.(289-291)cGc>cAc	p.R97H		NM_006639.2	NP_006630.1	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	97					elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	GGTGCTGAGGCGGCACAAGAA	0.443000													16	73					0	0	1	0	0
ASB13	79754	broad.mit.edu	37	10	5693260	5693260	+	Missense_Mutation	SNP	A	A	C	rs139712171		TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:5693260A>C	ENST00000357700.6	-	3	324	c.298T>G	c.(298-300)Tgt>Ggt	p.C100G	ASB13_ENST00000479033.1_Intron	NM_024701.3	NP_078977.2	Q8WXK3	ASB13_HUMAN	ankyrin repeat and SOCS box containing 13	100					intracellular signal transduction		protein binding			NS(1)|endometrium(3)|lung(3)|ovary(1)	8				GBM - Glioblastoma multiforme(2;9.59e-09)		AGCTTCACACACTCGATGCTG	0.632000													20	74					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395342	1395342	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr16:1395342G>A	ENST00000324385.5	+	22	2296	c.2138G>A	c.(2137-2139)tGg>tAg	p.W713*	BAIAP3_ENST00000421665.2_Nonsense_Mutation_p.W642*|BAIAP3_ENST00000562208.1_Nonsense_Mutation_p.W655*|BAIAP3_ENST00000426824.3_Nonsense_Mutation_p.W678*|BAIAP3_ENST00000397489.1_Nonsense_Mutation_p.W695*|BAIAP3_ENST00000397488.2_Nonsense_Mutation_p.W695*|BAIAP3_ENST00000568887.1_Nonsense_Mutation_p.W650*	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	713	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				CAGGCCAAGTGGAGGCTTCAG	0.682000													5	81					0	0	1	0	0
RIMKLA	284716	broad.mit.edu	37	1	42880615	42880615	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:42880615C>T	ENST00000431473.3	+	5	1275	c.1146C>T	c.(1144-1146)aaC>aaT	p.N382N		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	382					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						ACATTAACAACAGGATTGCTT	0.458000													12	133					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19523634	19523634	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:19523634C>T	ENST00000375267.2	-	8	1022		c.e8+1		UBR4_ENST00000375254.3_Splice_Site|UBR4_ENST00000375217.2_Splice_Site|UBR4_ENST00000375226.2_Splice_Site			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TAACTTCTCACCTGCATACAG	0.428000													20	83					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	330125	330125	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr12:330125A>T	ENST00000343164.4	-	15	1850	c.1798T>A	c.(1798-1800)Tct>Act	p.S600T	SLC6A13_ENST00000445055.2_Missense_Mutation_p.S508T	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	600					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TAGCAGTGAGACTCTAGCTCT	0.662000													6	48					0	0	1	0	0
SLC25A43	203427	broad.mit.edu	37	X	118540573	118540573	+	Silent	SNP	A	A	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:118540573A>T	ENST00000217909.7	+	2	770	c.426A>T	c.(424-426)ccA>ccT	p.P142P	SLC25A43_ENST00000336249.7_Silent_p.P142P|SLC25A43_ENST00000488158.1_3'UTR	NM_145305.2	NP_660348.2	Q8WUT9	S2543_HUMAN	solute carrier family 25, member 43	142					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	9						TACTGGAACCATCGTACAGGG	0.488000													22	204					0	0	1	0	0
PANK4	55229	broad.mit.edu	37	1	2452693	2452693	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:2452693C>T	ENST00000378466.3	-	3	281	c.269G>A	c.(268-270)cGa>cAa	p.R90Q	PANK4_ENST00000435556.3_Missense_Mutation_p.R90Q	NM_018216.1	NP_060686.1	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	90					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			breast(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	23	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GAAGTGCAGTCGAGCAGTGAT	0.502000													4	165					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2436221	2436221	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:2436221C>T	ENST00000419816.2	+	22	4094	c.3820C>T	c.(3820-3822)Cgc>Tgc	p.R1274C	PLCH2_ENST00000449969.1_3'UTR|PLCH2_ENST00000378488.3_Missense_Mutation_p.R1238C|PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000378486.3_Missense_Mutation_p.R1274C			O75038	PLCH2_HUMAN	phospholipase C, eta 2	1274					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GGGCGGCTCCCGCAGACTGAG	0.687000													13	22					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104																											TTGAAACAGCTGGTGTATTAA	0.373000													3	37					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7406572	7406572	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr17:7406572G>A	ENST00000322644.6	+	17	3288	c.2889G>A	c.(2887-2889)cgG>cgA	p.R963R		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	963					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GGGAGGATCGGGAGGTGCTCA	0.602000													6	125					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93301832	93301832	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:93301832G>A	ENST00000370321.3	+	5	500	c.410G>A	c.(409-411)gGt>gAt	p.G137D		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	137					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		AGCATTGATGGTCAGCCAGGT	0.483000													5	139					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													5	96					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301252	11301252	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:11301252G>A	ENST00000397056.1	+	3	720	c.529G>A	c.(529-531)Gag>Aag	p.E177K	HRH1_ENST00000431010.2_Missense_Mutation_p.E177K|HRH1_ENST00000438284.2_Missense_Mutation_p.E177K	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	177					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GGTGCGCCGAGAGGACAAGTG	0.522000													10	240					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767734	105767734	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr9:105767734A>T	ENST00000374798.3	+	5	891	c.821A>T	c.(820-822)aAg>aTg	p.K274M	CYLC2_ENST00000487798.1_Missense_Mutation_p.K274M	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	274	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				AAGAAAGATAAGAAGAAGCCC	0.393000													72	99					0	0	1	0	0
TMEM201	199953	broad.mit.edu	37	1	9661304	9661304	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:9661304C>T	ENST00000340305.5	+	5	757	c.748C>T	c.(748-750)Ctg>Ttg	p.L250L	TMEM201_ENST00000377376.4_Silent_p.L250L|TMEM201_ENST00000340381.6_Silent_p.L250L	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	250						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		GCCCCTGGCCCTGCCACCTGG	0.697000													12	26					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716492	142716492	+	Silent	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:142716492A>G	ENST00000381779.4	-	2	2658	c.2433T>C	c.(2431-2433)taT>taC	p.Y811Y	SLITRK4_ENST00000338017.4_Silent_p.Y811Y|SLITRK4_ENST00000356928.1_Silent_p.Y811Y	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	811						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGTTCAAAATACTCACTCT	0.413000													5	242					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75205560	75205560	+	Splice_Site	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr17:75205560T>C	ENST00000413679.2	+	14	1914		c.e14+2		SEC14L1_ENST00000430767.4_Splice_Site|SEC14L1_ENST00000392476.2_Splice_Site|SEC14L1_ENST00000443798.4_Splice_Site|SEC14L1_ENST00000436233.4_Splice_Site|SEC14L1_ENST00000591437.1_Splice_Site|SEC14L1_ENST00000431431.2_Splice_Site|SEC14L1_ENST00000585618.1_Splice_Site	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)						transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CCACATGAGGTACGTCCTCCG	0.612000													10	36					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36124351	36124351	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr5:36124351T>A	ENST00000296603.4	-	7	1226	c.764A>T	c.(763-765)aAt>aTt	p.N255I		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	255						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATGCTTTCATTCACTTTACG	0.274000													36	56					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113539732	113539732	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr4:113539732G>T	ENST00000505019.1	-	6	1591	c.1466C>A	c.(1465-1467)tCt>tAt	p.S489Y	C4orf21_ENST00000309071.5_Missense_Mutation_p.S489Y|C4orf21_ENST00000445203.2_Missense_Mutation_p.S458Y	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	489										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ATTATTACTAGATTCAATTTG	0.333000													44	183					5.78141e-17	6.03648e-17	1	1	0
FAM47E-STBD1	0	broad.mit.edu	37	4	77228080	77228080	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr4:77228080A>C	ENST00000237642.6	+	1	902	c.158A>C	c.(157-159)cAt>cCt	p.H53P	FAM47E-STBD1_ENST00000539752.1_Intron|FAM47E_ENST00000515604.1_Intron	NM_003943.4	NP_003934.1																					CCGGGAGGCCATCAGAGTGGC	0.667000											OREG0016232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	19					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37708164	37708164	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr22:37708164G>A	ENST00000248901.6	+	12	1248	c.1061G>A	c.(1060-1062)cGc>cAc	p.R354H		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	354	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						GAATCGTACCGCATCTCAGCC	0.622000													50	61					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30602556	30602556	+	Silent	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:30602556T>C	ENST00000358107.4	-	10	2120	c.2121A>G	c.(2119-2121)acA>acG	p.T707T	MTPAP_ENST00000488290.1_5'UTR|MTPAP_ENST00000263063.3_Silent_p.T577T			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	577					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						GAGTACTAATTGTTCTCTTCC	0.348000													6	406					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	830602	830602	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr16:830602C>T	ENST00000293892.3	-	3	398	c.399G>A	c.(397-399)gcG>gcA	p.A133A	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CGTGCAGGCACGCATGTGTAG	0.557000													7	466					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81598290	81598290	+	Splice_Site	SNP	C	C	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr7:81598290C>G	ENST00000356860.3	-	29	2647		c.e29-1		CACNA2D1_ENST00000356253.5_Splice_Site|CACNA2D1_ENST00000535308.1_Intron	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1							voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GGTCCACTTTCtaaaaaaaaa	0.284000													5	214					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49097830	49097830	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr15:49097830C>T	ENST00000380950.2	-	2	204	c.17G>A	c.(16-18)gGc>gAc	p.G6D	CEP152_ENST00000399334.3_Missense_Mutation_p.G6D|CEP152_ENST00000325747.5_Missense_Mutation_p.G6D	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	6					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TGCCACACTGCCAAAGTCTAA	0.398000													7	144					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61835771	61835771	+	Missense_Mutation	SNP	C	C	T	rs143606308		TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:61835771C>T	ENST00000280772.1	-	37	5059	c.4868G>A	c.(4867-4869)cGa>cAa	p.R1623Q	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1623	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGGAGAGGTTCGAGAGGAAAA	0.478000													89	111					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000327122.5_Silent_p.Q341Q|MAML3_ENST00000509479.2_Silent_p.Q497Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													5	87					0	0	1	0	0
C1orf115	79762	broad.mit.edu	37	1	220870064	220870064	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:220870064C>T	ENST00000294889.5	+	2	978	c.420C>T	c.(418-420)ttC>ttT	p.F140F		NM_024709.4	NP_078985.3	Q9H7X2	CA115_HUMAN	chromosome 1 open reading frame 115	140						integral to membrane				large_intestine(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0273)		TGGTATCCTTCGTGCGCTAAT	0.592000													16	156					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100868816	100868816	+	Silent	SNP	C	C	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:100868816C>A	ENST00000369208.3	-	10	1799	c.1017G>T	c.(1015-1017)ggG>ggT	p.G339G	SIM1_ENST00000262901.4_Silent_p.G339G			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	339	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AGAGCTGCAGCCCTTTGTATT	0.502000													3	50					6.4e-05	6.44539e-05	1	1	0
PLS3	5358	broad.mit.edu	37	X	114880830	114880830	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:114880830G>C	ENST00000420625.2	+	13	1620	c.1486G>C	c.(1486-1488)Gct>Cct	p.A496P	PLS3_ENST00000355899.3_Missense_Mutation_p.A496P|PLS3_ENST00000289290.3_Missense_Mutation_p.A460P|PLS3_ENST00000543070.1_Missense_Mutation_p.A90P|PLS3_ENST00000539310.1_Missense_Mutation_p.A451P|PLS3_ENST00000537301.1_Missense_Mutation_p.A483P	NM_001136025.3|NM_001172335.1	NP_001129497.1|NP_001165806.1	P13797	PLST_HUMAN	plastin 3	496	Actin-binding 2.|CH 3.					cytoplasm	actin binding|calcium ion binding			NS(2)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)	26						CCTGACTTTAGCTTTAGTCTG	0.413000													4	260					0	0	1	0	0
PABPC1L	80336	broad.mit.edu	37	20	43561000	43561000	+	Silent	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr20:43561000A>G	ENST00000255136.3	+	9	1339	c.1257A>G	c.(1255-1257)gcA>gcG	p.A419A	PABPC1L_ENST00000490798.1_Intron|PABPC1L_ENST00000372819.1_5'UTR|PABPC1L_ENST00000372824.1_5'UTR|PABPC1L_ENST00000217073.2_Silent_p.A419A|PABPC1L_ENST00000537323.1_Intron	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	419	Pro-rich.						nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						CCCAGGCTGCATACTATGGCT	0.622000													21	99					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159711	152159711	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:152159711G>A	ENST00000439251.1	-	2	870	c.432C>T	c.(430-432)tcC>tcT	p.S144S	PNMA5_ENST00000452693.1_Silent_p.S144S|PNMA5_ENST00000361887.5_Silent_p.S144S|PNMA5_ENST00000535214.1_Silent_p.S144S	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	144					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					CTAAAGGTGGGGATCTAACTT	0.537000													33	385					0	0	1	0	0
FAM47E-STBD1	0	broad.mit.edu	37	4	77228079	77228079	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr4:77228079C>T	ENST00000237642.6	+	1	901	c.157C>T	c.(157-159)Cat>Tat	p.H53Y	FAM47E-STBD1_ENST00000539752.1_Intron|FAM47E_ENST00000515604.1_Intron	NM_003943.4	NP_003934.1																					TCCGGGAGGCCATCAGAGTGG	0.667000											OREG0016232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	19					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100813689	100813689	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr12:100813689G>A	ENST00000323346.5	+	12	1835	c.1522G>A	c.(1522-1524)Gag>Aag	p.E508K	SLC17A8_ENST00000392989.3_Missense_Mutation_p.E458K|SLC17A8_ENST00000552697.1_3'UTR	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	508					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						GGAGAAACAGGAGTGGGCTGA	0.483000													4	107					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108384958	108384958	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr11:108384958G>A	ENST00000265843.4	-	6	1386	c.1276C>T	c.(1276-1278)Cgt>Tgt	p.R426C	EXPH5_ENST00000443411.1_Missense_Mutation_p.R238C|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000525344.1_Missense_Mutation_p.R419C|EXPH5_ENST00000428840.1_Missense_Mutation_p.R350C	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	426					intracellular protein transport		Rab GTPase binding	p.R426C(1)		breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AAACTAACACGTTGGTAAACA	0.413000													8	377					0	0	1	0	0
SULT1A2	6799	broad.mit.edu	37	16	28606983	28606983	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr16:28606983C>T	ENST00000533150.1	-	2	1278	c.162G>A	c.(160-162)gtG>gtA	p.V54V	SULT1A2_ENST00000395630.1_Silent_p.V54V|SULT1A2_ENST00000335715.4_Silent_p.V54V			P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	54					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|skin(2)	14						GAATCTGGCTCACCCAGGTGG	0.607000													12	163					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832503	61832503	+	Silent	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:61832503T>C	ENST00000280772.1	-	37	8327	c.8136A>G	c.(8134-8136)caA>caG	p.Q2712Q	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2712					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGAGTTTAGATTGTTTGAGCT	0.453000													5	387					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219920186	219920186	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:219920186C>T	ENST00000295731.5	-	3	978	c.979G>A	c.(979-981)Ggg>Agg	p.G327R		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	327					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGTAGGCCCCGAGGGCCACG	0.672000													4	42					0	0	1	0	0
VDR	0	broad.mit.edu	37	12	48272841	48272841	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr12:48272841T>C	ENST00000229022.3	-	4	337	c.56A>G	c.(55-57)aAc>aGc	p.N19S	VDR_ENST00000550325.1_Missense_Mutation_p.N69S|VDR_ENST00000549336.1_Missense_Mutation_p.N19S|VDR_ENST00000395324.2_Missense_Mutation_p.N19S|VDR_ENST00000535672.1_5'UTR	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	19					decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CCGGGGCACGTTCCGGTCAAA	0.587000													13	106					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								73	110					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5782302	5782302	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:5782302G>A	ENST00000328090.5	+	13	2794	c.2169G>A	c.(2167-2169)ccG>ccA	p.P723P	RP11-336A10.2_ENST00000411512.2_RNA	NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	723																	ATCGACCACCGTCTGCCCGTG	0.498000													12	202					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108214765	108214765	+	Nonsense_Mutation	SNP	A	A	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:108214765A>T	ENST00000369002.4	-	16	1774	c.1595T>A	c.(1594-1596)tTa>tAa	p.L532*		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	532	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding	p.L532*(2)		endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TTTTTTTTTTAAAGGTTTCTT	0.368000													8	240					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791758	42791758	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr19:42791758G>A	ENST00000572681.2	+	6	3439	c.3371G>A	c.(3370-3372)cGg>cAg	p.R1124Q	CIC_ENST00000160740.3_Missense_Mutation_p.R215Q|CIC_ENST00000575354.2_Missense_Mutation_p.R215Q			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	215	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.R215Q(2)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				AAGCGGCACCGGGCCCTGGTC	0.612000			"""Mis, F, S"""		oligodendroglioma								68	6					0	0	1	0	0
CORO1A	11151	broad.mit.edu	37	16	30199764	30199764	+	Missense_Mutation	SNP	G	G	A	rs61736366		TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr16:30199764G>A	ENST00000219150.5	+	10	1453	c.1148G>A	c.(1147-1149)cGg>cAg	p.R383Q	CORO1A_ENST00000570045.1_Missense_Mutation_p.R383Q|CORO1A_ENST00000565497.1_Intron	NM_001193333.2|NM_007074.3	NP_001180262.1|NP_009005.1	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	383					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						CTGGGGGGTCGGGATGCTGGG	0.697000													23	193					0	0	1	0	0
THSD1	55901	broad.mit.edu	37	13	52972267	52972267	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr13:52972267T>C	ENST00000349258.4	-	3	665	c.121A>G	c.(121-123)Aca>Gca	p.T41A	THSD1_ENST00000258613.4_Missense_Mutation_p.T41A|THSD1_ENST00000544466.1_Intron	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	41						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		ACATACACTGTGTCGTTGCTT	0.438000													27	216					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36793054	36793054	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:36793054C>T	ENST00000399881.3	+	27	3103	c.3066C>T	c.(3064-3066)gcC>gcT	p.A1022A		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1022						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCCGGCCAGCCAATGAGTTCA	0.458000													9	245					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69688649	69688649	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:69688649G>A	ENST00000337103.4	+	10	2679	c.1087G>A	c.(1087-1089)Gga>Aga	p.G363R	C8orf34_ENST00000539993.1_Missense_Mutation_p.G388R|C8orf34_ENST00000518698.1_Missense_Mutation_p.G474R|C8orf34_ENST00000325233.3_Missense_Mutation_p.G132R			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	388					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			AGCCTCCAGTGGAGTAGGACA	0.408000													5	167					0	0	1	0	0
HMX1	3166	broad.mit.edu	37	4	8869848	8869848	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr4:8869848C>T	ENST00000400677.3	-	2	820	c.618G>A	c.(616-618)acG>acA	p.T206T	HMX1_ENST00000506970.2_Intron	NM_018942.2	NP_061815.2	Q9NP08	HMX1_HUMAN	H6 family homeobox 1	206					multicellular organismal development|negative regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										AGACTGTGCGCGTCTTCTTCT	0.726000													2	1					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288802	107288802	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr9:107288802G>A	ENST00000277216.3	-	1	688	c.689C>T	c.(688-690)tCg>tTg	p.S230L		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S230*(1)		breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TCCTGTGGCCGAGTTCGTTCG	0.418000													5	266					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46391072	46391072	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr11:46391072G>A	ENST00000454345.1	+	6	1162	c.1037G>A	c.(1036-1038)cGt>cAt	p.R346H	DGKZ_ENST00000318201.8_Missense_Mutation_p.R158H|DGKZ_ENST00000395574.3_Missense_Mutation_p.R124H|DGKZ_ENST00000421244.2_Missense_Mutation_p.R158H|DGKZ_ENST00000456247.2_Missense_Mutation_p.R157H|DGKZ_ENST00000343674.6_Missense_Mutation_p.R174H|DGKZ_ENST00000532868.2_Missense_Mutation_p.R162H|DGKZ_ENST00000528615.1_5'UTR|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000527911.1_Missense_Mutation_p.R158H	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	346					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CCGTCCTTCCGTGAATCAGGC	0.572000											OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	199					0	0	1	0	0
ABRACL	58527	broad.mit.edu	37	6	139363876	139363876	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:139363876G>A	ENST00000367660.3	+	3	282	c.82G>A	c.(82-84)Gtg>Atg	p.V28M		NM_021243.2	NP_067066.1	Q9P1F3	CF115_HUMAN	ABRA C-terminal like	28																	AAAGTTAAGCGTGAAATTTGG	0.368000													8	349					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43822061	43822061	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr15:43822061A>G	ENST00000382031.1	+	6	8994	c.8963A>G	c.(8962-8964)aAt>aGt	p.N2988S	MAP1A_ENST00000399453.1_Missense_Mutation_p.N2750S|MAP1A_ENST00000300231.5_Missense_Mutation_p.N2750S			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2750						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TGGGGGGAGAATCTTCAGGTG	0.557000													5	69					0	0	1	0	0
KRTAP5-6	440023	broad.mit.edu	37	11	1718511	1718511	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr11:1718511C>T	ENST00000382160.1	+	1	87	c.36C>T	c.(34-36)tcC>tcT	p.S12S		NM_001012416.1	NP_001012416.1	Q6L8G9	KRA56_HUMAN	keratin associated protein 5-6	12						keratin filament				endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCTGTGGCTCCGGCTGTGGGG	0.642000													21	360					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183676100	183676100	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr4:183676100A>G	ENST00000511685.1	+	22	4703	c.4580A>G	c.(4579-4581)aAt>aGt	p.N1527S	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.N1527S					teneurin transmembrane protein 3																		TTTGACATCAATGGTACTCAC	0.383000													6	113					0	0	1	0	0
RFWD3	55159	broad.mit.edu	37	16	74695259	74695259	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr16:74695259T>C	ENST00000361070.4	-	2	186	c.89A>G	c.(88-90)cAa>cGa	p.Q30R	RFWD3_ENST00000571750.1_Missense_Mutation_p.Q30R	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	30					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						TGGTCCCCCTTGGCTGCTGGC	0.567000													13	325					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53644041	53644041	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:53644041C>A	ENST00000342160.3	-	20	2304	c.1847G>T	c.(1846-1848)cGa>cTa	p.R616L	HUWE1_ENST00000218328.8_Missense_Mutation_p.R616L|HUWE1_ENST00000262854.6_Missense_Mutation_p.R616L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	616					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTGAAGACCTCGGGCATTCAA	0.478000													26	69					4.72057e-08	4.89286e-08	1	1	0
OR52I1	390037	broad.mit.edu	37	11	4615307	4615307	+	Silent	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr11:4615307T>C	ENST00000450052.2	+	2	111	c.111T>C	c.(109-111)ccT>ccC	p.P37P	OR52I1_ENST00000530443.2_Silent_p.P13P			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGAAACCCCTGCCTCCTTCC	0.473000													68	330					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103052532	103052532	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr11:103052532A>T	ENST00000375735.2	+	40	6538	c.6394A>T	c.(6394-6396)Aat>Tat	p.N2132Y	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.N2132Y	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2132	AAA 2 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTGGTTGAGGAATCAGCCTGC	0.289000													7	14					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22064961	22064961	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:22064961G>A	ENST00000306385.5	+	18	3177	c.2507G>A	c.(2506-2508)cGc>cAc	p.R836H	BMP1_ENST00000354870.5_3'UTR	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	836	CUB 4.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		ACAGGCAGCCGCATGTTCCTG	0.642000													4	152					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281360	49281360	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr13:49281360G>A	ENST00000282018.3	+	1	410	c.407G>A	c.(406-408)cGt>cAt	p.R136H		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	136					immune response	integral to membrane|plasma membrane		p.R136H(1)		endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	AGTGTTGTGCGTTTCCTGGCA	0.473000													5	389					0	0	1	0	0
SCNN1B	0	broad.mit.edu	37	16	23392080	23392080	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr16:23392080G>A	ENST00000343070.2	+	13	2057	c.1881G>A	c.(1879-1881)ccG>ccA	p.P627P	SCNN1B_ENST00000307331.5_Silent_p.P672P|SCNN1B_ENST00000568923.1_Silent_p.P600P|SCNN1B_ENST00000568085.1_Silent_p.P591P	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	627					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	GTCTGCAGCCGCTGGACGTCA	0.677000													14	225					0	0	1	0	0
CYP3A5	0	broad.mit.edu	37	7	99250313	99250313	+	Silent	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr7:99250313T>C	ENST00000343703.5	-	12	1472	c.1086A>G	c.(1084-1086)agA>agG	p.R362R	CYP3A5_ENST00000339843.2_3'UTR|CYP3A5_ENST00000222982.4_Silent_p.R372R					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					TCCTCTCAAGTCTAATAGCAA	0.443000													18	151					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35280566	35280566	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr7:35280566C>T	ENST00000408931.3	-	5	1264	c.738G>A	c.(736-738)ctG>ctA	p.L246L		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	246						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						CTTCAGACTTCAGGTTGAGCA	0.393000													4	118					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193019013	193019013	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:193019013A>G	ENST00000342358.4	-	24	2879	c.2762T>C	c.(2761-2763)tTa>tCa	p.L921S	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	921					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ATAGAGCAGTAATGCACTGAT	0.348000													21	291					0	0	1	0	0
PCCB	5096	broad.mit.edu	37	3	136046565	136046565	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:136046565G>A	ENST00000471595.1	+	13	1407	c.1389G>A	c.(1387-1389)atG>atA	p.M463I	PCCB_ENST00000462637.1_Missense_Mutation_p.M440I|PCCB_ENST00000474833.1_3'UTR|PCCB_ENST00000482086.1_Missense_Mutation_p.M347I|PCCB_ENST00000251654.4_Missense_Mutation_p.M463I|PCCB_ENST00000468777.1_Missense_Mutation_p.M494I|PCCB_ENST00000490504.1_Missense_Mutation_p.M406I|PCCB_ENST00000483687.1_Missense_Mutation_p.M444I|PCCB_ENST00000466072.1_Missense_Mutation_p.M483I|PCCB_ENST00000478469.1_Intron|PCCB_ENST00000469217.1_Missense_Mutation_p.M483I			P05166	PCCB_HUMAN	propionyl CoA carboxylase, beta polypeptide	463	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	25					Biotin(DB00121)|L-Valine(DB00161)	TTGCAGTCATGGGAGCAAAGG	0.522000													29	43					0	0	1	0	0
IGHV3-16	0	broad.mit.edu	37	14	106622275	106622275	+	RNA	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr14:106622275A>G	ENST00000390604.2	-	0	120																											CACTCACTCAATATCCTTAGT	0.443000													8	267					0	0	1	0	0
IKZF5	64376	broad.mit.edu	37	10	124758013	124758013	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:124758013C>T	ENST00000368886.5	-	3	449	c.129G>A	c.(127-129)caG>caA	p.Q43Q	IKZF5_ENST00000479103.1_5'UTR	NM_001271840.1	NP_001258769.1	Q9H5V7	IKZF5_HUMAN	IKAROS family zinc finger 5 (Pegasus)	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|lung(3)|prostate(1)	6		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		GTCTACCTCCCTGAAGAGCCT	0.413000													4	152					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890403	2890403	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:2890403C>T	ENST00000380698.4	-	7	1214	c.1125G>A	c.(1123-1125)tcG>tcA	p.S375S		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	375					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				CCCTTTATGGCGATGAGAACC	0.542000													47	42					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073095	17073095	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr22:17073095G>A	ENST00000359963.3	-	1	605	c.346C>T	c.(346-348)Ctg>Ttg	p.L116L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	116					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCCTGTTCCAGCAAGGCTTCC	0.662000													30	47					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101972002	101972002	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:101972002G>C	ENST00000543253.1	+	5	3124	c.2205G>C	c.(2203-2205)aaG>aaC	p.K735N	GPRASP2_ENST00000535209.1_Missense_Mutation_p.K735N|GPRASP2_ENST00000332262.5_Missense_Mutation_p.K735N	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						CGAGAACGAAGTTTCACGTTC	0.393000													27	297					0	0	1	0	0
CDC7	8317	broad.mit.edu	37	1	91989862	91989862	+	Nonsense_Mutation	SNP	T	T	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:91989862T>G	ENST00000428239.1	+	12	1854	c.1595T>G	c.(1594-1596)tTa>tGa	p.L532*	CDC7_ENST00000234626.6_Nonsense_Mutation_p.L532*|CDC7_ENST00000430031.2_Nonsense_Mutation_p.L504*	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	532	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		aATACCAATTTAGAAGGCTGG	0.388000													15	212					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85777115	85777115	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:85777115T>G	ENST00000233838.3	-	15	2299	c.2219A>C	c.(2218-2220)gAt>gCt	p.D740A	GGCX_ENST00000430215.3_Missense_Mutation_p.D683A	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	740					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	ATGTGAAGAATCCGTGTTTGA	0.507000													41	65					0	0	1	0	0
RYBP	23429	broad.mit.edu	37	3	72427764	72427764	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:72427764C>G	ENST00000477973.1	-	4	723	c.724G>C	c.(724-726)Gag>Cag	p.E242Q		NM_012234.5	NP_036366.3	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	0					apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			prostate(1)|upper_aerodigestive_tract(1)	2		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		GTGCAGTGCTCCTGTCCACGT	0.483000													6	147					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48790318	48790318	+	Nonsense_Mutation	SNP	A	A	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:48790318A>T	ENST00000314191.2	-	41	5383	c.5327T>A	c.(5326-5328)tTa>tAa	p.L1776*	PRKDC_ENST00000338368.3_Nonsense_Mutation_p.L1776*|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	1777					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGATTGAAATAATTCTTCCAT	0.413000								Non-homologous end-joining					8	238					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160604539	160604539	+	Silent	SNP	G	G	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:160604539G>T	ENST00000302035.6	-	3	913	c.564C>A	c.(562-564)gcC>gcA	p.A188A	SLAMF1_ENST00000538290.1_Silent_p.A188A|SLAMF1_ENST00000235739.5_Silent_p.A188A|SLAMF1_ENST00000355199.3_Silent_p.A188A	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	188	Ig-like C2-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GGGAGCTGTTGGCTGGGTTCA	0.587000													11	196					3.86212e-05	3.91729e-05	1	1	0
RNGTT	8732	broad.mit.edu	37	6	89600293	89600293	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:89600293G>A	ENST00000369485.4	-	8	1003	c.817C>T	c.(817-819)Cct>Tct	p.P273S	RNGTT_ENST00000369475.3_Missense_Mutation_p.P273S|RNGTT_ENST00000265607.6_Missense_Mutation_p.P273S|RNGTT_ENST00000538899.1_Missense_Mutation_p.P213S	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	273	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		ATGGAAACAGGCTGTGCTCCA	0.383000													44	80					0	0	1	0	0
SLC52A3	113278	broad.mit.edu	37	20	745940	745940	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr20:745940C>T	ENST00000381944.3	-	2	720	c.479G>A	c.(478-480)gGc>gAc	p.G160D	SLC52A3_ENST00000473664.1_5'UTR|SLC52A3_ENST00000217254.7_Missense_Mutation_p.G160D			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	160					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										GAGACCGGAGCCCTGGGCAAG	0.602000													35	95					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48349704	48349704	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr7:48349704G>C	ENST00000435803.1	+	24	9506	c.9482G>C	c.(9481-9483)aGt>aCt	p.S3161T		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3161					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GTGTTGCTGAGTCGAAACTTG	0.512000													11	458					0	0	1	0	0
CRIP2	1397	broad.mit.edu	37	14	105945493	105945493	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr14:105945493G>A	ENST00000329146.4	+	6	1151	c.438G>A	c.(436-438)tgG>tgA	p.W146*	CRIP2_ENST00000483017.3_Nonsense_Mutation_p.W220*|CRIP2_ENST00000548989.1_3'UTR	NM_001312.2	NP_001303.1	P52943	CRIP2_HUMAN	cysteine-rich protein 2	146	LIM zinc-binding 2.						zinc ion binding			lung(2)	2		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.235)		GCAAGGATTGGCACCGGCCCT	0.766000													3	35					0	0	1	0	0
SERP2	387923	broad.mit.edu	37	13	44953804	44953804	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr13:44953804G>A	ENST00000379179.3	+	2	296	c.112G>A	c.(112-114)Gga>Aga	p.G38R		NM_001010897.1	NP_001010897.1	Q8N6R1	SERP2_HUMAN	stress-associated endoplasmic reticulum protein family member 2	38					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				large_intestine(1)	1		all_hematologic(4;1.49e-06)|Acute lymphoblastic leukemia(4;1.5e-06)|Lung NSC(96;0.00043)|Breast(139;0.0044)|Prostate(109;0.0137)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;0.00026)|BRCA - Breast invasive adenocarcinoma(63;0.123)		ATATCCTGTGGGACCATGGCT	0.413000													17	175					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27279865	27279865	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:27279865G>A	ENST00000397501.1	+	10	1324	c.516G>A	c.(514-516)gaG>gaA	p.E172E	PTK2B_ENST00000338238.4_Silent_p.E172E|PTK2B_ENST00000544172.1_Silent_p.E172E|PTK2B_ENST00000346049.5_Silent_p.E172E|PTK2B_ENST00000517339.1_Silent_p.E172E|PTK2B_ENST00000420218.2_Silent_p.E172E	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	172	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		AGGTCAGCGAGGGCATGGCCC	0.652000													3	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615659	179615659	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:179615659A>G	ENST00000360870.5	-	46	11690	c.11468T>C	c.(11467-11469)tTa>tCa	p.L3823S	TTN_ENST00000591111.1_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9657							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCACCATATAAATGGTCTTT	0.363000													47	212					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149323960	149323960	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr5:149323960G>A	ENST00000255266.5	-	1	396	c.277C>T	c.(277-279)Cgc>Tgc	p.R93C		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	93	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AGGCTCATGCGGTCTGCCTGC	0.517000													27	101					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121414352	121414352	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr11:121414352G>A	ENST00000260197.7	+	13	1910	c.1781G>A	c.(1780-1782)aGc>aAc	p.S594N	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	594					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GGGGAGAAGAGCACTGTCTTC	0.517000													28	274					0	0	1	0	0
TNNI3K	51086	broad.mit.edu	37	1	74954885	74954885	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:74954885T>A	ENST00000370891.2	+	24	2453	c.2437T>A	c.(2437-2439)Ttt>Att	p.F813I	FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.F813I|LRRC53_ENST00000294635.4_Intron|TNNI3K_ENST00000326637.3_Missense_Mutation_p.F712I	NM_001112808.2	NP_001106279.1			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						AAGACCCGAATTTTCTGAAGT	0.348000													10	70					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109109230	109109230	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:109109230T>A	ENST00000309863.6	+	19	5145	c.4431T>A	c.(4429-4431)aaT>aaA	p.N1477K		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1477					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						AGCTTAAGAATGAACCGACCA	0.388000													5	80					0	0	1	0	0
RHOBTB3	22836	broad.mit.edu	37	5	95088046	95088046	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr5:95088046A>C	ENST00000379982.3	+	5	1182	c.674A>C	c.(673-675)gAa>gCa	p.E225A	GLRX_ENST00000508780.1_Intron	NM_014899.3	NP_055714.3	O94955	RHBT3_HUMAN	Rho-related BTB domain containing 3	225					retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|skin(1)	16		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		CCTCAACTTGAACAACCAGGT	0.348000													6	206					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46656908	46656908	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:46656908A>G	ENST00000544460.1	+	1	1297	c.1043A>G	c.(1042-1044)tAt>tGt	p.Y348C	TDRD6_ENST00000316081.6_Missense_Mutation_p.Y348C	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	348	Tudor 2.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			CATGTGGACTATGGAAGGAAG	0.532000													7	125					0	0	1	0	0
SERPIND1	3053	broad.mit.edu	37	22	21134208	21134208	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr22:21134208G>A	ENST00000215727.5	+	2	891	c.608G>A	c.(607-609)cGt>cAt	p.R203H	SERPIND1_ENST00000406799.1_Missense_Mutation_p.R203H|PI4KA_ENST00000572273.1_Intron|PI4KA_ENST00000255882.6_Intron|PI4KA_ENST00000466162.1_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	203	Glycosaminoglycan-binding site.				blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	AATCTCTTCCGTAAGCTGACT	0.433000													4	205					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59404091	59404091	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:59404091C>A	ENST00000301645.3	-	6	1595	c.1458G>T	c.(1456-1458)ttG>ttT	p.L486F		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	486					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GCAAAATGCCCAAGCCTGCCC	0.383000									Neonatal Giant Cell Hepatitis				22	106					8.10497e-08	8.3399e-08	1	1	0
EIF2D	1939	broad.mit.edu	37	1	206772892	206772892	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:206772892T>C	ENST00000271764.2	-	10	1335	c.1127A>G	c.(1126-1128)tAt>tGt	p.Y376C	EIF2D_ENST00000367114.3_Missense_Mutation_p.Y252C	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	376					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TGGAGGGTGATAGGGCTGTTC	0.532000													6	159					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39846201	39846201	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:39846201G>A	ENST00000538976.1	+	13	1564	c.1382G>A	c.(1381-1383)cGt>cAt	p.R461H	DAAM2_ENST00000398904.2_Missense_Mutation_p.R461H|DAAM2_ENST00000274867.4_Missense_Mutation_p.R461H	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	461					actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					CTTGTGAGCCGTCTGGAGAGG	0.547000													7	15					0	0	1	0	0
ZNF788	388507	broad.mit.edu	37	19	12221205	12221205	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr19:12221205G>A	ENST00000430298.2	+	2	294	c.89G>A	c.(88-90)cGa>cAa	p.R30Q	ZNF20_ENST00000600335.1_Intron|ZNF788_ENST00000596883.1_Missense_Mutation_p.R50Q|ZNF788_ENST00000339302.4_5'UTR					zinc finger family member 788											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	2						AATCTCTACCGAGAAGTGATG	0.458000													17	89					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27442064	27442064	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr17:27442064G>A	ENST00000527372.1	-	14	2552	c.2372C>T	c.(2371-2373)cCg>cTg	p.P791L	MYO18A_ENST00000533112.1_Missense_Mutation_p.P791L|MYO18A_ENST00000354329.4_Missense_Mutation_p.P791L|MYO18A_ENST00000531253.1_Missense_Mutation_p.P791L	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	791	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CTGGAAGCCCGGGGTGTCGAC	0.637000													6	64					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10363351	10363351	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr17:10363351C>T	ENST00000255381.2	-	14	1444	c.1334G>A	c.(1333-1335)cGc>cAc	p.R445H	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	445	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CTGGTTGATGCGGGTGACCAT	0.478000													6	416					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900377	151900377	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:151900377T>A	ENST00000393900.3	-	3	777	c.424A>T	c.(424-426)Aat>Tat	p.N142Y	MAGEA12_ENST00000357916.4_Missense_Mutation_p.N142Y|MAGEA12_ENST00000393869.3_Missense_Mutation_p.N142Y|CSAG4_ENST00000361201.4_RNA	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	142	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTGGAAATTTCTGATGACA	0.507000													5	457					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150770028	150770028	+	Translation_Start_Site	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:150770028G>A	ENST00000370357.4	+	2	248	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	1						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					AATAATGAATGAAGATGAGAG	0.408000													7	199					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176011568	176011568	+	Silent	SNP	G	G	A	rs147485475		TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr5:176011568G>A	ENST00000510636.1	+	19	2560	c.2286G>A	c.(2284-2286)ccG>ccA	p.P762P	CDHR2_ENST00000506348.1_Silent_p.P762P|CDHR2_ENST00000261944.5_Silent_p.P762P	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	762	Cadherin 7.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GGCTGCCCCCGGACGTGAGCC	0.622000													5	237					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37734844	37734844	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:37734844C>T	ENST00000330843.4	-	2	609	c.597G>A	c.(595-597)tcG>tcA	p.S199S	RAB11FIP1_ENST00000287263.4_Silent_p.S199S|RAB11FIP1_ENST00000524118.1_Silent_p.S51S|RAB11FIP1_ENST00000522727.1_Silent_p.S51S	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	199					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CACTGTCGACCGAAGGTGTCG	0.468000													11	406					0	0	1	0	0
ACTR2	10097	broad.mit.edu	37	2	65467018	65467018	+	Silent	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:65467018T>C	ENST00000260641.5	+	2	238	c.81T>C	c.(79-81)ttT>ttC	p.F27F	ACTR2_ENST00000377982.4_Silent_p.F27F|ACTR2_ENST00000542850.1_5'UTR|ACTR2_ENST00000476840.1_3'UTR	NM_005722.3	NP_005713.1	P61160	ARP2_HUMAN	ARP2 actin-related protein 2 homolog (yeast)	27					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	12						GCTCTAACTTTCCAGAACACA	0.343000													23	208					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													3	69					0	0	1	0	0
IGHV3-9	0	broad.mit.edu	37	14	106552458	106552458	+	RNA	SNP	C	C	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr14:106552458C>G	ENST00000390600.2	-	0	260																											AGGCCCTTCCCTGGAGCTTGC	0.562000													4	264					0	0	1	0	0
CDCA7	83879	broad.mit.edu	37	2	174231959	174231959	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:174231959C>G	ENST00000306721.3	+	9	1370	c.1267C>G	c.(1267-1269)Ctt>Gtt	p.L423V	CDCA7_ENST00000347703.3_Missense_Mutation_p.L344V|CDCA7_ENST00000410101.3_Missense_Mutation_p.L379V|CDCA7_ENST00000392567.2_Missense_Mutation_p.L294V|CDCA7_ENST00000410019.3_Missense_Mutation_p.L302V	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	344					regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			GACTGGGGTCCTTGTGTATTT	0.468000													5	231					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4904034	4904034	+	Missense_Mutation	SNP	G	G	A	rs151076376	byFrequency	TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr11:4904034G>A	ENST00000380378.1	+	1	986	c.986G>A	c.(985-987)cGc>cAc	p.R329H	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron|OR51T1_ENST00000322049.1_Missense_Mutation_p.R302H	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R302L(1)|p.R329L(1)		NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGACAATCCGCCAGGCTATG	0.483000													11	189					0	0	1	0	0
CCDC142	84865	broad.mit.edu	37	2	74709771	74709771	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr2:74709771T>G	ENST00000393965.3	-	1	590	c.194A>C	c.(193-195)gAg>gCg	p.E65A	CCDC142_ENST00000290418.4_Missense_Mutation_p.E65A|CCDC142_ENST00000471713.1_Intron	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	65										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						CTCGTAGTCCTCGCTCACATC	0.716000													12	45					0	0	1	0	0
MLF1	4291	broad.mit.edu	37	3	158314692	158314692	+	Silent	SNP	G	G	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:158314692G>C	ENST00000359117.5	+	3	398	c.162G>C	c.(160-162)gtG>gtC	p.V54V	MLF1_ENST00000482628.1_Silent_p.V54V|MLF1_ENST00000469452.1_Silent_p.V54V|MLF1_ENST00000497004.1_3'UTR|MLF1_ENST00000471745.1_Silent_p.V69V|MLF1_ENST00000484955.1_Silent_p.V54V|MLF1_ENST00000478894.2_Silent_p.V69V|MLF1_ENST00000392822.3_Silent_p.V110V|MLF1_ENST00000355893.5_Silent_p.V79V	NM_001130156.2	NP_001123628.1	P58340	MLF1_HUMAN	myeloid leukemia factor 1	79	Interaction with COPS3.				cell cycle arrest|myeloid progenitor cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein domain specific binding			large_intestine(3)	3		Melanoma(1037;0.000458)|Prostate(884;0.0235)|all_neural(597;0.0299)	Lung(72;0.00199)|LUSC - Lung squamous cell carcinoma(72;0.00256)			ACCAAATGGTGTCAAATATGA	0.313000			T	NPM1	AML								3	72					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637146	248637146	+	Silent	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:248637146C>T	ENST00000359594.2	+	1	520	c.495C>T	c.(493-495)acC>acT	p.T165T		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTTGCTCACCCCCATTACCA	0.537000													21	114					0	0	1	0	0
SYTL4	94121	broad.mit.edu	37	X	99934381	99934381	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:99934381C>A	ENST00000455616.1	-	16	1933	c.1587G>T	c.(1585-1587)caG>caT	p.Q529H	SYTL4_ENST00000372989.1_Missense_Mutation_p.Q529H|SYTL4_ENST00000263033.5_Missense_Mutation_p.Q529H|SYTL4_ENST00000276141.6_Missense_Mutation_p.Q529H|SYTL4_ENST00000454200.2_Missense_Mutation_p.Q531H			Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	529	C2 2.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(2)	27					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGATCCACACCTGGAGCTCTC	0.512000													38	107					8.16277e-20	8.58603e-20	1	1	0
MYH14	79784	broad.mit.edu	37	19	50784917	50784917	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr19:50784917C>T	ENST00000440075.2	+	33	4404	c.4357C>T	c.(4357-4359)Cgc>Tgc	p.R1453C	MYH14_ENST00000601313.1_Missense_Mutation_p.R1453C|MYH14_ENST00000598205.1_Missense_Mutation_p.R1420C|MYH14_ENST00000596571.1_Missense_Mutation_p.R1412C|MYH14_ENST00000425460.1_Missense_Mutation_p.R1420C|MYH14_ENST00000376970.2_Missense_Mutation_p.R1445C|MYH14_ENST00000262269.8_Missense_Mutation_p.R1453C			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1412					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGAGGCACGGCGCCGGGCAGC	0.726000													8	1					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96740964	96740964	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:96740964G>A	ENST00000260682.6	+	7	998	c.986G>A	c.(985-987)cGt>cAt	p.R329H		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	329					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GAGATTGAACGTGTGATTGGC	0.463000													17	248					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117662871	117662871	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr12:117662871G>A	ENST00000317775.6	-	25	4461	c.3776C>T	c.(3775-3777)gCc>gTc	p.A1259V	NOS1_ENST00000338101.4_Missense_Mutation_p.A1293V|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1259					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCGGAAAGGGGCAATGCCGGT	0.607000													5	336					0	0	1	0	0
NOS1AP	9722	broad.mit.edu	37	1	162313631	162313631	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:162313631G>A	ENST00000361897.5	+	6	862	c.460G>A	c.(460-462)Gct>Act	p.A154T	NOS1AP_ENST00000530878.1_Missense_Mutation_p.A149T	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	154	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			CCAGAGCCAAGCTATGAGAAT	0.537000													9	197					0	0	1	0	0
HSPA1L	0	broad.mit.edu	37	6	31779583	31779583	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:31779583G>A	ENST00000375654.4	-	2	356	c.167C>T	c.(166-168)gCg>gTg	p.A56V	HSPA1L_ENST00000417199.3_Missense_Mutation_p.A56V	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	56					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GTTCTTGGCCGCATCCCCAAT	0.532000													5	302					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212566	26212566	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:26212566G>A	ENST00000379034.1	+	2	752	c.603G>A	c.(601-603)acG>acA	p.T201T		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	201	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						AGGCGTGCACGTTGGCGCAAT	0.483000													9	222					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170843805	170843805	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:170843805G>A	ENST00000436636.2	-	17	2253	c.1909C>T	c.(1909-1911)Cgc>Tgc	p.R637C	TNIK_ENST00000488470.1_Missense_Mutation_p.R582C|TNIK_ENST00000538048.1_Missense_Mutation_p.R582C|TNIK_ENST00000475336.1_Missense_Mutation_p.R553C|TNIK_ENST00000470834.1_Missense_Mutation_p.R608C|TNIK_ENST00000460047.1_Missense_Mutation_p.R582C|TNIK_ENST00000284483.8_Missense_Mutation_p.R637C|TNIK_ENST00000369326.5_Missense_Mutation_p.R608C|TNIK_ENST00000357327.5_Missense_Mutation_p.R608C|TNIK_ENST00000341852.6_Missense_Mutation_p.R553C	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	637	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.R637C(2)		cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GAGTTCTGGCGTGGCATCTCC	0.572000													28	95					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72127688	72127688	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:72127688T>C	ENST00000340726.3	-	16	2170	c.1531A>G	c.(1531-1533)Aaa>Gaa	p.K511E	EYA1_ENST00000388742.4_Missense_Mutation_p.K511E|EYA1_ENST00000419131.1_Missense_Mutation_p.K476E|EYA1_ENST00000388743.2_Missense_Mutation_p.K510E|EYA1_ENST00000388740.3_Missense_Mutation_p.K478E|EYA1_ENST00000303824.7_Missense_Mutation_p.K505E|EYA1_ENST00000388741.2_Missense_Mutation_p.K477E	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	511					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity	p.K511*(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AGCAGGACTTTCGCCAATGCT	0.338000													9	258					0	0	1	0	0
PCDHGA12	0	broad.mit.edu	37	5	140810520	140810520	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr5:140810520G>A	ENST00000252085.3	+	1	336	c.194G>A	c.(193-195)cGc>cAc	p.R65H	PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGGAGTCCGCATCATCCCC	0.657000													9	239					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148865734	148865734	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr6:148865734C>G	ENST00000367467.3	+	18	3603	c.3128C>G	c.(3127-3129)cCt>cGt	p.P1043R		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1043	Pro-rich.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GCTCCCAGGCCTCTCTCAGGG	0.697000													4	44					0	0	1	0	0
NMNAT1	64802	broad.mit.edu	37	1	10042595	10042595	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:10042595A>G	ENST00000377205.1	+	5	820	c.676A>G	c.(676-678)Atc>Gtc	p.I226V		NM_022787.3	NP_073624.2	Q9HAN9	NMNA1_HUMAN	nicotinamide nucleotide adenylyltransferase 1	226					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding			large_intestine(2)|lung(2)|stomach(1)	5		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		ATCCACAAAAATCCGGAGAGC	0.448000													71	11					0	0	1	0	0
BTK	695	broad.mit.edu	37	X	100617592	100617592	+	Silent	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chrX:100617592G>A	ENST00000308731.7	-	6	640	c.477C>T	c.(475-477)gcC>gcT	p.A159A	BTK_ENST00000372880.1_Silent_p.A159A	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	159					calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TAGCATTTTTGGCTGTCTGAG	0.438000									Agammaglobulinemia, X-linked				5	297					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18428052	18428052	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:18428052G>A	ENST00000338745.6	-	8	2992	c.1258C>T	c.(1258-1260)Cag>Tag	p.Q420*	SATB1_ENST00000417717.2_Nonsense_Mutation_p.Q420*|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Nonsense_Mutation_p.Q420*	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	420					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AGCAAAGACTGGGATGCAGTC	0.502000													7	184					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95412677	95412677	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:95412677C>T	ENST00000336148.5	-	7	1083	c.959G>A	c.(958-960)tGt>tAt	p.C320Y		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			AATAGCTCCACATCTGCCATT	0.373000								Direct reversal of damage;Homologous recombination					12	51					0	0	1	0	0
RP11-206L10.2	0	broad.mit.edu	37	1	700514	700514	+	RNA	DEL	A	A	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:700514delA	ENST00000428504.1	-	0	1039					NR_033908.1																						actccatctcaaaaaaaaaaa	0.453													2	4	---	---	---	---					
SETDB1	9869	broad.mit.edu	37	1	150922948	150922950	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr1:150922948_150922950delCCA	ENST00000271640.5	+	13	1785_1787	c.1595_1597delCCA	c.(1594-1599)tca>t	p.ST532del	SETDB1_ENST00000368969.4_In_Frame_Del_p.ST532del|SETDB1_ENST00000459773.1_Intron	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	532					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCTTTAGGCTCCACAGCCTCTGC	0.576													10	265	---	---	---	---					
QARS	5859	broad.mit.edu	37	3	49139864	49139866	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:49139864_49139866delCTC	ENST00000306125.6	-	6	893_895	c.556_558delGAG	c.(556-558)del	p.E186del	QARS_ENST00000420147.2_In_Frame_Del_p.E204del|QARS_ENST00000470225.1_5'UTR|QARS_ENST00000414533.1_In_Frame_Del_p.E175del			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	186					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	TGAACTTCTTCTCCAGATCAGCC	0.576													9	159	---	---	---	---					
USP4	7375	broad.mit.edu	37	3	49365164	49365166	+	In_Frame_Del	DEL	TAG	TAG	-	rs143074429	byFrequency	TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:49365164_49365166delTAG	ENST00000351842.4	-	3	321_323	c.313_315delCTA	c.(313-315)del	p.L105del	USP4_ENST00000265560.4_In_Frame_Del_p.L105del|USP4_ENST00000416417.1_In_Frame_Del_p.L105del|USP4_ENST00000415188.1_In_Frame_Del_p.L105del	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	105	DUSP.				negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CGTACCAGTTTAGTAGTTTATTC	0.443													17	181	---	---	---	---					
ZNF717	100131827	broad.mit.edu	37	3	75790810	75790811	+	Frame_Shift_Ins	INS	-	-	T	rs76346895		TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:75790810_75790811insT	ENST00000422325.1	-	3	456_457	c.134_135insA	c.(133-135)actfs	p.T45fs	ZNF717_ENST00000478296.1_5'UTR|ZNF717_ENST00000400845.3_Frame_Shift_Ins_p.T38fs|ZNF717_ENST00000491507.1_5'UTR|ZNF717_ENST00000477374.1_Frame_Shift_Ins_p.T45fs	NM_001128223.1	NP_001121695.1	C9JSV9	C9JSV9_HUMAN	zinc finger protein 717	45					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			autonomic_ganglia(6)|endometrium(3)|lung(2)|ovary(1)|stomach(7)	19						CCCTGTACAGGGTCCTCTGAGC	0.510													5	6	---	---	---	---					
SDHAP1	0	broad.mit.edu	37	3	195690462	195690463	+	RNA	INS	-	-	G			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr3:195690462_195690463insG	ENST00000427841.1	-	0	2203					NR_003264.2																						catgcgcaacaggggactgtaa	0.366													3	5	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100268753	100268754	+	RNA	INS	-	-	ATTTAT	rs35500540	byFrequency	TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr4:100268753_100268754insATTTAT	ENST00000515683.1	-	0	472				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AAAATTTAACAATTTATACTTT	0.243													3	4	---	---	---	---					
MEPCE	56257	broad.mit.edu	37	7	100028465	100028465	+	Frame_Shift_Del	DEL	C	C	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr7:100028465delC	ENST00000310512.2	+	1	1212	c.824delC	c.(823-825)gafs	p.A276fs	MEPCE_ENST00000414441.1_5'UTR	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	276							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAGCAGCAGGCAGCCGGAGGG	0.652													28	311	---	---	---	---					
TMEM70	54968	broad.mit.edu	37	8	74893730	74893733	+	Frame_Shift_Del	DEL	GTTA	GTTA	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr8:74893730_74893733delGTTA	ENST00000312184.5	+	3	730_733	c.657_660delGTTA	c.(655-660)ctfs	p.LL219fs		NM_001040613.2|NM_017866.5	NP_001035703.1|NP_060336.3	Q9BUB7	TMM70_HUMAN	transmembrane protein 70	219					mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane|mitochondrial inner membrane				breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	8	Breast(64;0.0311)		Epithelial(68;0.0186)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0564)			CAAAATCACTGTTAGTTAATCCAG	0.348													20	178	---	---	---	---					
PSAP	5660	broad.mit.edu	37	10	73580004	73580006	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:73580004_73580006delTTG	ENST00000394936.3	-	9	1143_1145	c.996_998delCAA	c.(994-999)aag>aa	p.NK332del	PSAP_ENST00000394934.1_In_Frame_Del_p.NK334del			P07602	SAP_HUMAN	prosaposin	332	Saposin B-type 3.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						TACCTCAGTCTTGTTGTTGTCAA	0.557													11	178	---	---	---	---					
ARMS2	387715	broad.mit.edu	37	10	124214434	124214435	+	In_Frame_Ins	INS	-	-	CAT			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr10:124214434_124214435insCAT	ENST00000528446.1	+	1	266_267	c.191_192insCAT	c.(190-192)tat>tCATat	p.64_65insS		NM_001099667.1	NP_001093137.1	P0C7Q2	ARMS2_HUMAN	age-related maculopathy susceptibility 2	64					retina homeostasis	mitochondrion|photoreceptor inner segment				ovary(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTATCACACTCCATGATCCCAG	0.540													84	97	---	---	---	---					
AC026495.1	0	broad.mit.edu	37	15	20563423	20563423	+	RNA	DEL	C	C	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr15:20563423delC	ENST00000581090.1	+	0	63																											cccttcctctcccttcctctc	0.672													5	2	---	---	---	---					
RFX7	64864	broad.mit.edu	37	15	56387780	56387780	+	Frame_Shift_Del	DEL	T	T	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr15:56387780delT	ENST00000423270.1	-	9	2145	c.2146delA	c.(2146-2148)gcfs	p.S716fs	RFX7_ENST00000317318.6_Frame_Shift_Del_p.S716fs|RFX7_ENST00000559447.2_Frame_Shift_Del_p.S619fs|RFX7_ENST00000422057.1_Frame_Shift_Del_p.S619fs	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	619					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						GATACCTTGCTAGGAATCTGA	0.438													34	119	---	---	---	---					
TCF12	6938	broad.mit.edu	37	15	57523426	57523427	+	Frame_Shift_Ins	INS	-	-	T			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr15:57523426_57523427insT	ENST00000267811.5	+	9	960_961	c.656_657insT	c.(655-657)aatfs	p.N219fs	TCF12_ENST00000543579.1_Frame_Shift_Ins_p.N49fs|TCF12_ENST00000560764.1_3'UTR|TCF12_ENST00000343827.3_Frame_Shift_Ins_p.N49fs|TCF12_ENST00000438423.2_Frame_Shift_Ins_p.N219fs|TCF12_ENST00000333725.5_Frame_Shift_Ins_p.N219fs|TCF12_ENST00000452095.2_Frame_Shift_Ins_p.N215fs|TCF12_ENST00000537840.1_Frame_Shift_Ins_p.M30fs|TCF12_ENST00000557843.1_Frame_Shift_Ins_p.N219fs	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12	219					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CCACCAACCAGTATGTTCGCTA	0.366			T	TEC	extraskeletal myxoid chondrosarcoma								45	233	---	---	---	---					
LA16c-23H5.4	0	broad.mit.edu	37	22	16419352	16419352	+	RNA	DEL	T	T	-			TCGA-S9-A6WH-01A-12D-A33T-08	TCGA-S9-A6WH-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d0f21bc-09ad-40c6-ad40-8db35c89b50f	a6aec60a-7190-429c-82d3-cecd9b189962	g.chr22:16419352delT	ENST00000444162.1	+	0	279																											GAATCGACGATTTTTTTTTTG	0.398													2	4	---	---	---	---					
