Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													3	55					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65376868	65376868	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr3:65376868G>T	ENST00000330909.8	-	14	2364	c.2365C>A	c.(2365-2367)Cca>Aca	p.P789T	MAGI1_ENST00000497477.2_Missense_Mutation_p.P789T|MAGI1_ENST00000402939.2_Missense_Mutation_p.P789T|MAGI1_ENST00000483466.1_Missense_Mutation_p.P789T	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	789					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding	p.P789T(2)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		AAAGGATCTGGTTTTTTCTGG	0.567000													9	79					0.000274275	0.000274275	1	1	0
DENND2C	163259	broad.mit.edu	37	1	115130509	115130509	+	Silent	SNP	A	A	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:115130509A>G	ENST00000393274.1	-	19	3121	c.2496T>C	c.(2494-2496)caT>caC	p.H832H	DENND2C_ENST00000393277.1_Silent_p.H720H|DENND2C_ENST00000393276.3_Silent_p.H775H|DENND2C_ENST00000481894.1_5'UTR	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	832	dDENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCAAAGAATAATGTCCTACCA	0.453000													9	42					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55357560	55357560	+	Silent	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr12:55357560C>T	ENST00000524622.1	-	6	868	c.207G>A	c.(205-207)agG>agA	p.R69R	TESPA1_ENST00000531122.1_Silent_p.R69R|TESPA1_ENST00000532804.1_Silent_p.R69R|TESPA1_ENST00000449076.1_Silent_p.R207R|TESPA1_ENST00000316577.8_Silent_p.R207R|TESPA1_ENST00000524959.1_5'UTR	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	207																	CCATTTCAATCCTCCGCACCT	0.542000													14	18					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2752024	2752024	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr7:2752024C>T	ENST00000312371.4	+	7	1377	c.1009C>T	c.(1009-1011)Ccg>Tcg	p.P337S	AMZ1_ENST00000489665.1_Intron|AMZ1_ENST00000407112.1_Missense_Mutation_p.A280V	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	337							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		GGCGGGGGAGCCGTCAGTGTG	0.672000													7	17					0	0	1	0	0
CEP68	23177	broad.mit.edu	37	2	65299194	65299194	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr2:65299194C>T	ENST00000377990.2	+	3	1167	c.964C>T	c.(964-966)Cgt>Tgt	p.R322C	CEP68_ENST00000497039.1_3'UTR|CEP68_ENST00000546106.1_Missense_Mutation_p.R322C|CEP68_ENST00000260569.4_Missense_Mutation_p.R322C|RAB1A_ENST00000494188.1_Intron|CEP68_ENST00000537589.1_5'UTR	NM_015147.2	NP_055962.2	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	322					centrosome organization	centrosome				breast(1)|endometrium(6)|kidney(8)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32						CCTTGATAGCCGTGTGCCAGC	0.547000													20	74					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220108252	220108252	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr2:220108252G>A	ENST00000295759.7	-	2	357	c.44C>T	c.(43-45)cCg>cTg	p.P15L	GLB1L_ENST00000356283.3_Missense_Mutation_p.P15L|GLB1L_ENST00000409640.1_Missense_Mutation_p.P15L|GLB1L_ENST00000392089.2_Missense_Mutation_p.P15L			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	15					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGGCTGAGCGGCAGCAGCAG	0.612000													12	36					0	0	1	0	0
FBXO47	494188	broad.mit.edu	37	17	37118156	37118156	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:37118156G>A	ENST00000378079.2	-	3	525	c.326C>T	c.(325-327)gCt>gTt	p.A109V		NM_001008777.2	NP_001008777.2	Q5MNV8	FBX47_HUMAN	F-box protein 47	109								p.A109V(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	20						CTCCAGTATAGCAGAGTCTTG	0.358000													40	41					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2338249	2338249	+	Missense_Mutation	SNP	C	C	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr16:2338249C>A	ENST00000301732.5	-	21	3482	c.2782G>T	c.(2782-2784)Gca>Tca	p.A928S	ABCA3_ENST00000382381.3_Missense_Mutation_p.A870S	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	928					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				AGGACCTGTGCCGCCACCATT	0.637000													5	14					2.0095e-06	2.06308e-06	1	1	0
CACNA1I	8911	broad.mit.edu	37	22	40037050	40037050	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr22:40037050C>T	ENST00000336649.4	+	8	919	c.919C>T	c.(919-921)Cgc>Tgc	p.R307C	CACNA1I_ENST00000400164.3_Missense_Mutation_p.R307C|CACNA1I_ENST00000402142.3_Missense_Mutation_p.R307C|CACNA1I_ENST00000407673.1_Missense_Mutation_p.R307C|CACNA1I_ENST00000404898.1_Missense_Mutation_p.R307C|CACNA1I_ENST00000401624.1_Missense_Mutation_p.R307C			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	307					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TGGGGCGGGGCGCCAGGACCT	0.617000													4	101					0	0	1	0	0
MIR519B	0	broad.mit.edu	37	19	54198493	54198493	+	RNA	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:54198493G>A	ENST00000385090.1	+	0	27					NR_030191.1																						AGAGGGAAGCGCTTTCTGTTG	0.403000													94	76					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167675300	167675300	+	Silent	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr5:167675300G>A	ENST00000519204.1	+	26	7111	c.6993G>A	c.(6991-6993)ccG>ccA	p.P2331P	TENM2_ENST00000403607.2_Silent_p.P2276P|TENM2_ENST00000518659.1_Silent_p.P2452P|TENM2_ENST00000520394.1_Silent_p.P2213P|TENM2_ENST00000545108.1_Silent_p.P2451P					teneurin transmembrane protein 2																		GCAAGGAGCCGGCCCCCTTTA	0.507000													8	35					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099877	50099877	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:50099877A>G	ENST00000418929.2	+	4	2297	c.2285A>G	c.(2284-2286)aAg>aGg	p.K762R		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	470							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TTCTTGCAAAAGAGCCCTCCG	0.697000													9	13					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85780433	85780433	+	Silent	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr2:85780433G>A	ENST00000233838.3	-	8	1157	c.1077C>T	c.(1075-1077)cgC>cgT	p.R359R	GGCX_ENST00000473665.1_5'UTR|GGCX_ENST00000430215.3_Silent_p.R302R	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	359					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	CCAGCTGATGGCGCAGCCCTG	0.577000													17	105					0	0	1	0	0
PCDHAC1	0	broad.mit.edu	37	5	140307730	140307730	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr5:140307730C>T	ENST00000253807.2	+	1	1253	c.1253C>T	c.(1252-1254)tCa>tTa	p.S418L	PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.S418L|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCACGGCCTCAGATAGTGGC	0.517000													19	46					0	0	1	0	0
IGHV1-18	0	broad.mit.edu	37	14	106641975	106641975	+	RNA	SNP	A	A	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr14:106641975A>G	ENST00000390605.2	-	0	81																											CACCAAGAAAAGGATGCTCCA	0.557000													5	50					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11835397	11835397	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:11835397C>T	ENST00000262442.3	+	64	12240	c.12172C>T	c.(12172-12174)Cat>Tat	p.H4058Y	DNAH9_ENST00000454412.2_Missense_Mutation_p.H3982Y|DNAH9_ENST00000396001.2_Missense_Mutation_p.H370Y	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4058	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTGTTACTTCCATGCGGTGGT	0.483000													54	192					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155255062	155255062	+	RNA	SNP	C	C	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chrX:155255062C>G	ENST00000285718.7	+	0	1367				WASH6P_ENST00000461007.1_RNA																							CACCTTCCCCCCCAGACCCAG	0.627000													5	28					0	0	1	0	0
BCL9	607	broad.mit.edu	37	1	147091685	147091685	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:147091685G>A	ENST00000234739.3	+	8	2464	c.1724G>A	c.(1723-1725)gGg>gAg	p.G575E		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	575	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding	p.G575V(1)		breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					GAAATGGAAGGGCCGAATGTC	0.557000			T	"""IGH@, IGL@"""	B-ALL								4	108					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625905	29625905	+	Missense_Mutation	SNP	T	T	C	rs137871677	by1000genomes	TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr20:29625905T>C	ENST00000278882.3	+	5	529	c.149T>C	c.(148-150)cTt>cCt	p.L50P	FRG1B_ENST00000439954.2_Missense_Mutation_p.L55P|FRG1B_ENST00000358464.4_Missense_Mutation_p.L50P														p.L50P(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGAAAATATCTTGGTATAAAT	0.333000													5	121					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578458	7578458	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:7578458G>T	ENST00000420246.2	-	5	604	c.472C>A	c.(472-474)Cgc>Agc	p.R158S	TP53_ENST00000413465.2_Missense_Mutation_p.R158S|TP53_ENST00000445888.2_Missense_Mutation_p.R158S|TP53_ENST00000455263.2_Missense_Mutation_p.R158S|TP53_ENST00000359597.4_Missense_Mutation_p.R158S|TP53_ENST00000269305.4_Missense_Mutation_p.R158S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	158	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158C(17)|p.R158G(16)|p.0?(8)|p.R158fs(6)|p.R158fs*12(6)|p.R158fs*11(6)|p.R65fs(2)|p.R65G(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.R26G(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R26fs(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R26fs*11(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.R156fs*12(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R65fs*11(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCATGGCGCGGACGCGGGTG	0.622000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	3					3.90053e-15	4.11425e-15	1	1	0
ZNF671	79891	broad.mit.edu	37	19	58232671	58232671	+	Silent	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:58232671G>A	ENST00000317398.6	-	4	878	c.783C>T	c.(781-783)gcC>gcT	p.A261A	AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000335820.3_Silent_p.A163A	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGCTGAGAGAGGCCTGATGCT	0.517000													12	52					0	0	1	0	0
XXbac-BPG308J9.3	0	broad.mit.edu	37	6	29231546	29231546	+	RNA	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr6:29231546G>A	ENST00000441381.1	+	0	79																											CGTGCATAGCGTCACATTAGT	0.433000													49	182					0	0	1	0	0
FAM213B	127281	broad.mit.edu	37	1	2519968	2519968	+	Splice_Site	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:2519968G>A	ENST00000484099.1	+	4	334		c.e4-1		FAM213B_ENST00000378424.4_Intron|FAM213B_ENST00000419916.2_Intron|FAM213B_ENST00000378425.5_Intron|FAM213B_ENST00000537325.1_Intron|FAM213B_ENST00000444521.2_Intron	NR_036638.1		Q8TBF2	PGFS_HUMAN	family with sequence similarity 213, member B						prostaglandin biosynthetic process	cytosol	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor										GATTGACTCAGGCTGTACCCA	0.632000													66	90					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155255043	155255043	+	RNA	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chrX:155255043G>A	ENST00000285718.7	+	0	1348				WASH6P_ENST00000461007.1_RNA																							ATCCTAGGGGGCTCCATGACA	0.642000													5	33					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28846701	28846701	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr16:28846701C>T	ENST00000336783.4	+	20	2833	c.2666C>T	c.(2665-2667)gCg>gTg	p.A889V	ATXN2L_ENST00000395547.2_Missense_Mutation_p.A889V|ATXN2L_ENST00000382686.4_Missense_Mutation_p.A889V|ATXN2L_ENST00000340394.8_Missense_Mutation_p.A889V|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000325215.6_Missense_Mutation_p.A889V|ATXN2L_ENST00000570200.1_Missense_Mutation_p.A889V|ATXN2L_ENST00000564304.1_Missense_Mutation_p.A895V	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	889						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						TCCCAGCATGCGGCCCCCAGT	0.632000													3	34					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82421687	82421687	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:82421687G>T	ENST00000370728.1	+	13	2593	c.1948G>T	c.(1948-1950)Gtc>Ttc	p.V650F	LPHN2_ENST00000271029.4_Missense_Mutation_p.V650F|LPHN2_ENST00000370730.1_Missense_Mutation_p.V650F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000319517.6_Missense_Mutation_p.V637F|LPHN2_ENST00000370721.1_Missense_Mutation_p.V575F|LPHN2_ENST00000394879.1_Missense_Mutation_p.V637F|LPHN2_ENST00000370725.1_Missense_Mutation_p.V650F|LPHN2_ENST00000370715.1_Missense_Mutation_p.V637F|LPHN2_ENST00000359929.3_Missense_Mutation_p.V637F|LPHN2_ENST00000370717.2_Missense_Mutation_p.V650F|LPHN2_ENST00000370713.1_Missense_Mutation_p.V637F|LPHN2_ENST00000335786.5_Missense_Mutation_p.V650F|LPHN2_ENST00000370723.1_Missense_Mutation_p.V637F|LPHN2_ENST00000370727.1_Missense_Mutation_p.V650F			O95490	LPHN2_HUMAN	latrophilin 2	650					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AGGAGCTTTTGTCCTAGCTGA	0.368000													27	34					1.16021e-09	1.20724e-09	1	1	0
TRPV1	7442	broad.mit.edu	37	17	3491593	3491593	+	Silent	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:3491593G>A	ENST00000174621.6	-	6	1396	c.1107C>T	c.(1105-1107)acC>acT	p.T369T	TRPV1_ENST00000399756.4_Silent_p.T371T|TRPV1_ENST00000425167.2_Silent_p.T382T|TRPV1_ENST00000571088.1_Silent_p.T371T|TRPV1_ENST00000399759.3_Silent_p.T371T|SHPK_ENST00000572705.1_Silent_p.T371T|TRPV1_ENST00000310522.5_Intron|TRPV1_ENST00000576351.1_Silent_p.T371T			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	371					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	AGGCCCACTCGGTGAACTTCC	0.637000													5	3					0	0	1	0	0
NDST1	3340	broad.mit.edu	37	5	149915331	149915331	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr5:149915331G>A	ENST00000261797.6	+	6	1823	c.1321G>A	c.(1321-1323)Gtg>Atg	p.V441M	NDST1_ENST00000523767.1_Missense_Mutation_p.V441M	NM_001543.4	NP_001534.1	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	441	Heparan sulfate N-deacetylase 1.				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCCGTGCACGTGCAGCTGTA	0.647000													12	22					0	0	1	0	0
C12orf42	374470	broad.mit.edu	37	12	103700000	103700000	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr12:103700000C>T	ENST00000548048.1	-	8	678	c.182G>A	c.(181-183)cGt>cAt	p.R61H	C12orf42_ENST00000548789.1_5'UTR|C12orf42_ENST00000378113.2_Missense_Mutation_p.R128H|C12orf42_ENST00000315192.8_Intron|C12orf42_ENST00000548883.1_Missense_Mutation_p.R128H			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	128								p.R128H(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						TGGAGAGGAACGGAATTCTTC	0.468000													11	24					0	0	1	0	0
MRPL27	51264	broad.mit.edu	37	17	48447454	48447454	+	Missense_Mutation	SNP	T	T	C	rs148980265		TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:48447454T>C	ENST00000442592.3	-	3	215	c.179A>G	c.(178-180)tAt>tGt	p.Y60C	MRPL27_ENST00000503633.1_Missense_Mutation_p.Y60C|MRPL27_ENST00000507088.1_Missense_Mutation_p.Y5C|MRPL27_ENST00000511860.1_Missense_Mutation_p.Y5C|MRPL27_ENST00000225969.4_Missense_Mutation_p.Y60C			Q9P0M9	RM27_HUMAN	mitochondrial ribosomal protein L27	60					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			endometrium(1)|large_intestine(2)|urinary_tract(1)	4	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;1.73e-07)			AGCATGAACATAGTGACCTAG	0.527000													24	25					0	0	1	0	0
UBE2F	140739	broad.mit.edu	37	2	238925257	238925257	+	Silent	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr2:238925257C>T	ENST00000272930.4	+	5	458	c.264C>T	c.(262-264)ccC>ccT	p.P88P	UBE2F_ENST00000409332.1_Silent_p.P66P|UBE2F-SCLY_ENST00000449191.1_Silent_p.P88P|UBE2F_ENST00000409633.1_Silent_p.P88P|UBE2F_ENST00000414443.1_Silent_p.P56P|UBE2F_ENST00000409953.1_Silent_p.P64P	NM_001278305.1|NM_080678.2	NP_001265234.1|NP_542409.1	Q969M7	UBE2F_HUMAN	ubiquitin-conjugating enzyme E2F (putative)	88					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding			endometrium(1)|large_intestine(1)	2		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)		CTGAAGTTCCCGATGCGTACA	0.458000													16	116					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170031819	170031819	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr2:170031819C>T	ENST00000263816.3	-	55	10937	c.10652G>A	c.(10651-10653)cGc>cAc	p.R3551H		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3551	LDL-receptor class A 27.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.R3551H(2)		biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCGGCAGAAGCGCTGCGGGCA	0.532000													28	25					0	0	1	0	0
TRBV5-7	0	broad.mit.edu	37	7	142111483	142111483	+	RNA	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr7:142111483C>T	ENST00000390378.1	-	0	252																											AACTGGTGACCTGAGAATTGA	0.522000													57	61					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683876	100683876	+	Missense_Mutation	SNP	T	T	G	rs145514577	byFrequency	TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr7:100683876T>G	ENST00000306151.4	+	3	9243	c.9179T>G	c.(9178-9180)aTt>aGt	p.I3060S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3060	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGTGGCCATTCCTGAGGCT	0.493000													4	242					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	65960387	65960387	+	Missense_Mutation	SNP	G	G	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr15:65960387G>C	ENST00000443035.3	-	28	5074	c.4859C>G	c.(4858-4860)tCt>tGt	p.S1620C	DENND4A_ENST00000431932.2_Missense_Mutation_p.S1577C	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	1577					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TGGACATTTAGACATAGCTGT	0.398000													30	22					0	0	1	0	0
ASNS	440	broad.mit.edu	37	7	97482450	97482450	+	Silent	SNP	T	T	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr7:97482450T>C	ENST00000175506.4	-	13	1926	c.1398A>G	c.(1396-1398)ccA>ccG	p.P466P	ASNS_ENST00000422745.1_Silent_p.P445P|ASNS_ENST00000394308.3_Silent_p.P466P|ASNS_ENST00000437628.1_Silent_p.P383P|ASNS_ENST00000444334.1_Silent_p.P445P|ASNS_ENST00000394309.3_Silent_p.P466P|ASNS_ENST00000455086.1_Silent_p.P383P	NM_183356.3	NP_899199.2	P08243	ASNS_HUMAN	asparagine synthetase (glutamine-hydrolyzing)	466	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGGCTTCTTTTGGTCGCCAGA	0.373000													13	58					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	27					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128671	45128671	+	RNA	SNP	T	T	G	rs1056072	by1000genomes	TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:45128671T>G	ENST00000575173.1	-	0	418																											GCTCACAAAATAAGTTCCAGG	0.323000													5	173					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2129435	2129435	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:2129435T>C	ENST00000355272.6	-	7	820	c.614A>G	c.(613-615)aAt>aGt	p.N205S	AP3D1_ENST00000350812.6_Intron|AP3D1_ENST00000345016.5_Missense_Mutation_p.N205S|AP3D1_ENST00000356926.4_Intron	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	205					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGATGACATTGACGGCAGC	0.577000													11	28					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52525405	52525405	+	Silent	SNP	G	G	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr3:52525405G>T	ENST00000345716.4	+	20	3914	c.3780G>T	c.(3778-3780)cgG>cgT	p.R1260R	NISCH_ENST00000479054.1_Silent_p.R1260R	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	1260					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		GCTTGACGCGGGACAGCTACC	0.647000													6	27					3.59834e-05	3.64568e-05	1	1	0
SIRT7	51547	broad.mit.edu	37	17	79872257	79872257	+	Silent	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:79872257C>T	ENST00000328666.6	-	7	791	c.729G>A	c.(727-729)ggG>ggA	p.G243G		NM_016538.2	NP_057622.1	Q9NRC8	SIRT7_HUMAN	sirtuin 7	243	Deacetylase sirtuin-type.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding	p.G243G(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GCCCCAACGTCCCCCTCTCCC	0.637000													17	22					0	0	1	0	0
HIST3H2BB	128312	broad.mit.edu	37	1	228646048	228646048	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:228646048G>A	ENST00000369160.2	+	1	241	c.218G>A	c.(217-219)cGc>cAc	p.R73H		NM_175055.2	NP_778225.1	Q8N257	H2B3B_HUMAN	histone cluster 3, H2bb	73					nucleosome assembly	nucleosome|nucleus	DNA binding	p.R73L(1)		skin(1)	1		Prostate(94;0.183)				ATCTTCGAGCGCATCGCCAGC	0.622000													4	133					0	0	1	0	0
CDC123	8872	broad.mit.edu	37	10	12238313	12238313	+	Missense_Mutation	SNP	C	C	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr10:12238313C>G	ENST00000281141.4	+	1	349	c.69C>G	c.(67-69)atC>atG	p.I23M	CDC123_ENST00000455773.3_3'UTR|CDC123_ENST00000378900.2_Missense_Mutation_p.I23M	NM_006023.2	NP_006014.2	O75794	CD123_HUMAN	cell division cycle 123	23					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12						GCGTTACCATCAAGAGGTGAG	0.567000													76	683					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47608994	47608994	+	Silent	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:47608994C>T	ENST00000371891.3	+	5	595	c.564C>T	c.(562-564)caC>caT	p.H188H	CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_3'UTR|CYP4A22_ENST00000371890.3_Silent_p.H188H|CYP4A22_ENST00000294337.3_Silent_p.H188H	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	188						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCTTTCAGCACGTCTCCTTGA	0.567000													9	38					0	0	1	0	0
FAM76B	143684	broad.mit.edu	37	11	95512069	95512069	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr11:95512069T>C	ENST00000358780.5	-	8	1057	c.745A>G	c.(745-747)Ata>Gta	p.I249V	FAM76B_ENST00000536839.1_Missense_Mutation_p.I248V	NM_144664.4	NP_653265.3	Q5HYJ3	FA76B_HUMAN	family with sequence similarity 76, member B	249										breast(1)|kidney(1)|lung(1)	3		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AATTGACTTATAAGGACAAAA	0.333000													23	43					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813322	248813322	+	Silent	SNP	G	G	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:248813322G>C	ENST00000344889.3	-	1	863	c.864C>G	c.(862-864)ctC>ctG	p.L288L		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGCTGTAAATGAGTGGATTGA	0.483000													10	19					0	0	1	0	0
DNAJC12	56521	broad.mit.edu	37	10	69571296	69571296	+	Missense_Mutation	SNP	C	C	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr10:69571296C>G	ENST00000225171.2	-	3	435	c.283G>C	c.(283-285)Gac>Cac	p.D95H	DNAJC12_ENST00000339758.7_Missense_Mutation_p.D95H|DNAJC12_ENST00000483798.2_Missense_Mutation_p.D125H	NM_021800.2	NP_068572.1	Q9UKB3	DJC12_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 12	95					protein folding		heat shock protein binding|unfolded protein binding			breast(2)|kidney(2)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	12						TTCACTGAGTCATTCAAAGCT	0.502000													20	57					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134080162	134080162	+	Splice_Site	SNP	A	A	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr11:134080162A>C	ENST00000534548.2	-	4	632		c.e4+1			NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3						cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CTTACTTCTTACCTCAATATC	0.383000													31	66					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38893436	38893436	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr4:38893436G>A	ENST00000358869.2	+	4	597	c.421G>A	c.(421-423)Gca>Aca	p.A141T	FAM114A1_ENST00000515037.1_5'UTR	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	141						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						GCTGTCGTCAGCATCTGCCAC	0.473000													21	30					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7522052	7522052	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr12:7522052G>A	ENST00000313599.3	-	15	3997	c.3940C>T	c.(3940-3942)Cgg>Tgg	p.R1314W	CD163L1_ENST00000396630.1_Missense_Mutation_p.R1314W|CD163L1_ENST00000416109.2_Missense_Mutation_p.R1324W			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1314	SRCR 12.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CCTTTGCACCGCATGTCATCC	0.572000													4	120					0	0	1	0	0
IPP	3652	broad.mit.edu	37	1	46179946	46179946	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:46179946T>C	ENST00000396478.3	-	8	1604	c.1502A>G	c.(1501-1503)cAt>cGt	p.H501R		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	501						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TTCTACAGTATGAAGAGCATC	0.408000													32	35					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36116679	36116679	+	Silent	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr22:36116679G>A	ENST00000249044.2	+	2	120	c.120G>A	c.(118-120)ggG>ggA	p.G40G		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	40					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						AGGTCTGGGGGAAGTCCccag	0.512000													181	191					0	0	1	0	0
FABP4	2167	broad.mit.edu	37	8	82392665	82392665	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr8:82392665A>G	ENST00000256104.4	-	2	337	c.242T>C	c.(241-243)gTc>gCc	p.V81A	RP11-157I4.4_ENST00000524085.2_RNA|FABP4_ENST00000518669.1_5'UTR	NM_001442.2	NP_001433.1	P15090	FABP4_HUMAN	fatty acid binding protein 4, adipocyte	81					triglyceride catabolic process	cytoplasm|nucleus|soluble fraction	fatty acid binding|protein binding|transporter activity			breast(2)|central_nervous_system(1)|large_intestine(1)|ovary(1)|skin(1)	6			Epithelial(68;0.213)			TCTCACCTTGACTTTCCTGTC	0.378000													20	85					0	0	1	0	0
ZNF124	7678	broad.mit.edu	37	1	247323000	247323000	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:247323000A>G	ENST00000472531.1	-	2	273	c.146T>C	c.(145-147)cTg>cCg	p.L49P	ZNF124_ENST00000340684.6_Missense_Mutation_p.L49P|ZNF124_ENST00000491356.1_Missense_Mutation_p.L49P|ZNF124_ENST00000543802.2_Missense_Mutation_p.L49P|ZNF124_ENST00000491848.1_5'UTR	NM_001243740.1	NP_001230669.1	Q15973	ZN124_HUMAN	zinc finger protein 124	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|urinary_tract(2)	14	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			TATGGAAGCCAGATTCCTGAA	0.413000													17	61					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155180800	155180800	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr4:155180800G>A	ENST00000357232.3	-	20	5320	c.5321C>T	c.(5320-5322)gCa>gTa	p.A1774V		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1774	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TATCAAGACTGCTACTTTGCA	0.393000													21	67					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119859	38119859	+	Silent	SNP	C	C	T	rs66505048		TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr22:38119859C>T	ENST00000406386.3	+	7	1551	c.1296C>T	c.(1294-1296)tgC>tgT	p.C432C	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	432					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.C432C(6)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAACATCCTGCGCCCAGCGGG	0.582000													6	120					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128685	45128685	+	RNA	SNP	T	T	C	rs145089594	by1000genomes	TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:45128685T>C	ENST00000575173.1	-	0	418																											TTCCAGGATATGGCTATACTG	0.303000													5	184					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102057259	102057259	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr10:102057259T>C	ENST00000318222.3	-	5	1218	c.836A>G	c.(835-837)cAg>cGg	p.Q279R	PKD2L1_ENST00000338519.3_Intron|PKD2L1_ENST00000353274.3_Missense_Mutation_p.Q279R	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	279					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TGCACTACCCTGTCGGGATCC	0.597000													11	1149					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61483616	61483616	+	Silent	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr17:61483616C>T	ENST00000424789.2	+	19	3349	c.3345C>T	c.(3343-3345)acC>acT	p.T1115T	AC015923.1_ENST00000431604.1_RNA|TANC2_ENST00000389520.4_Silent_p.T1115T|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1115							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						ATCTAGGAACCGTGGACTTTC	0.502000											OREG0024637	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	64					0	0	1	0	0
AQP2	359	broad.mit.edu	37	12	50349300	50349300	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr12:50349300C>T	ENST00000199280.3	+	4	810	c.725C>T	c.(724-726)cCg>cTg	p.P242L	RP11-469H8.6_ENST00000550530.1_RNA|RP11-469H8.8_ENST00000552806.1_RNA|RP11-469H8.6_ENST00000552379.1_RNA	NM_000486.5	NP_000477.1	P41181	AQP2_HUMAN	aquaporin 2 (collecting duct)	242					cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(4)|ovary(2)	10						GGCCTGGAGCCGGACACCGAT	0.692000													8	13					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90509453	90509453	+	Missense_Mutation	SNP	C	C	T	rs113382706		TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr14:90509453C>T	ENST00000335725.4	+	17	2043	c.1793C>T	c.(1792-1794)cCg>cTg	p.P598L	TDP1_ENST00000555880.1_Missense_Mutation_p.R562W|TDP1_ENST00000393452.3_3'UTR|TDP1_ENST00000393454.2_Missense_Mutation_p.P598L|TDP1_ENST00000357382.3_Missense_Mutation_p.P359L	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	598					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		GTCAAAGCACCGGATACGCAT	0.423000								Repair of DNA-protein crosslinks					10	34					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1041546	1041546	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:1041546T>C	ENST00000263094.6	+	3	335	c.104T>C	c.(103-105)cTc>cCc	p.L35P	ABCA7_ENST00000433129.1_Missense_Mutation_p.L35P	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	35					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCTCTTCCTCTTCTTCATC	0.647000													13	59					0	0	1	0	0
ZNF146	7705	broad.mit.edu	37	19	36727929	36727929	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:36727929G>A	ENST00000456324.1	+	3	2036	c.587G>A	c.(586-588)cGa>cAa	p.R196Q	ZNF146_ENST00000443387.2_Missense_Mutation_p.R196Q|ZNF565_ENST00000355114.5_Intron	NM_001099638.1|NM_001099639.1	NP_001093108.1|NP_001093109.1	Q15072	OZF_HUMAN	zinc finger protein 146	196					regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11	Esophageal squamous(110;0.162)					TTCTCTCAGCGAACATCACTT	0.418000													4	99					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26482183	26482183	+	Silent	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr10:26482183C>T	ENST00000265944.5	+	32	4654	c.4488C>T	c.(4486-4488)ccC>ccT	p.P1496P	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1496					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CAAGACGACCCCGGAAACCCA	0.378000													13	32					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155004069	155004069	+	Silent	SNP	C	C	T			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:155004069C>T	ENST00000368424.3	-	4	778	c.720G>A	c.(718-720)gcG>gcA	p.A240A	DCST2_ENST00000295536.5_Silent_p.A240A	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	240						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTCCACAGAGCGCCAGTTTGA	0.592000													11	51					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156761535	156761536	+	Frame_Shift_Ins	INS	-	-	C			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr1:156761535_156761536insC	ENST00000271526.4	+	4	1402_1403	c.1130_1131insC	c.(1129-1131)gccfs	p.A377fs	PRCC_ENST00000353233.3_Intron|PRCC_ENST00000491853.1_3'UTR	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	377					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding	p.Q380fs*12(1)	PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCGGCCCTGGTCCCCCCCCAGG	0.530			T	TFE3	papillary renal								8	364	---	---	---	---					
DNM1	1759	broad.mit.edu	37	9	130982298	130982298	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr9:130982298delG	ENST00000341179.7	+	5	713	c.621delG	c.(619-621)ctfs	p.L207fs	DNM1_ENST00000486160.1_Frame_Shift_Del_p.L207fs|DNM1_ENST00000475805.1_Frame_Shift_Del_p.L207fs|DNM1_ENST00000393594.3_Frame_Shift_Del_p.L207fs|DNM1_ENST00000372923.3_Frame_Shift_Del_p.L207fs	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	207					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						TCACCAAGCTGGACCTGATGG	0.632													2	4	---	---	---	---					
UPF2	26019	broad.mit.edu	37	10	11990430	11990432	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr10:11990430_11990432delCTT	ENST00000356352.2	-	15	3583_3585	c.3110_3112delAAG	c.(3109-3114)ggt>g	p.EG1037del	UPF2_ENST00000397053.2_In_Frame_Del_p.EG1037del|UPF2_ENST00000357604.5_In_Frame_Del_p.EG1037del			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	1037	Glu-rich.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				tcagccccaccttcttcttcttc	0.374													7	477	---	---	---	---					
DUSP5	1847	broad.mit.edu	37	10	112262511	112262512	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr10:112262511_112262512delGA	ENST00000369583.3	+	2	696_697	c.412_413delGA	c.(412-414)gfs	p.E138fs	DUSP5_ENST00000468749.1_3'UTR	NM_004419.3	NP_004410.3	Q16690	DUS5_HUMAN	dual specificity phosphatase 5	138	Rhodanese.				endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			kidney(2)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	13		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		GGAATATCCTGAGTGTTGCGTG	0.431													55	37	---	---	---	---					
ATM	472	broad.mit.edu	37	11	108158380	108158382	+	In_Frame_Del	DEL	GAC	GAC	-			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr11:108158380_108158382delGAC	ENST00000278616.4	+	27	4432_4434	c.4047_4049delGAC	c.(4045-4050)atg>at	p.MT1349del	ATM_ENST00000452508.2_In_Frame_Del_p.MT1349del	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1349					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGTTATTGATGACGTTACATGAG	0.345			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			71	7	---	---	---	---					
CCT2	10576	broad.mit.edu	37	12	69979304	69979304	+	Translation_Start_Site	DEL	G	G	-			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr12:69979304delG	ENST00000299300.6	+	0	191				CCT2_ENST00000544368.2_Start_Codon_Del	NM_006431.2	NP_006422.1	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2 (beta)						'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(1)	24	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TCGGAACCATGGTGAGCCTGA	0.622											OREG0021987	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
FAM98C	147965	broad.mit.edu	37	19	38899502	38899504	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:38899502_38899504delAAG	ENST00000252530.5	+	8	1049_1051	c.1030_1032delAAG	c.(1030-1032)del	p.K349del	FAM98C_ENST00000343358.7_In_Frame_Del_p.K267del|FAM98C_ENST00000588262.1_3'UTR	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	349										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TTGGGGTCGCAAGAAGAAGAAGA	0.606													8	50	---	---	---	---					
ZNF446	55663	broad.mit.edu	37	19	58991631	58991631	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TM-A84J-01A-11D-A36O-08	TCGA-TM-A84J-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d4929553-67d7-45f4-ab30-e8218b0fe697	7a11066b-492d-4df1-8136-7bd2739786ba	g.chr19:58991631delT	ENST00000594369.1	+	7	1272	c.891delT	c.(889-891)gcfs	p.A298fs	ZNF446_ENST00000596341.1_Intron|ZNF446_ENST00000335841.4_Frame_Shift_Del_p.L269fs	NM_017908.2	NP_060378.1	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	298	Pro-rich.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TGTCTGGGGCTGCCACTCCTG	0.721													3	5	---	---	---	---					
