Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RAP2C	57826	broad.mit.edu	37	X	131348282	131348282	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:131348282G>T	ENST00000342983.2	-	3	1212	c.466C>A	c.(466-468)Ctt>Att	p.L156I	RAP2C_ENST00000460462.1_5'UTR|RAP2C_ENST00000370874.1_Missense_Mutation_p.L156I	NM_001271186.1|NM_001271187.1|NM_021183.3	NP_001258115.1|NP_001258116.1|NP_067006.3	Q9Y3L5	RAP2C_HUMAN	RAP2C, member of RAS oncogene family	156					negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(2)	8	Acute lymphoblastic leukemia(192;0.000127)					TCAGCAAAAAGTTCATCCACC	0.443000													9	133					0.00621372	0.00644385	1	1	0
PCIF1	63935	broad.mit.edu	37	20	44569128	44569128	+	Silent	SNP	G	G	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr20:44569128G>T	ENST00000372409.3	+	5	628	c.264G>T	c.(262-264)ggG>ggT	p.G88G		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	88						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						ACCCTTTGGGGCTGAATGCGA	0.622000													3	11					1	1	1	1	0
DDX26B	203522	broad.mit.edu	37	X	134707958	134707958	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:134707958C>T	ENST00000370752.4	+	12	1935	c.1601C>T	c.(1600-1602)aCg>aTg	p.T534M	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	534										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCTGAAAACGCACAAGTTT	0.358000													5	60					0	0	1	0	0
ILK	3611	broad.mit.edu	37	11	6630830	6630830	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr11:6630830G>T	ENST00000396751.2	+	8	1272	c.816G>T	c.(814-816)atG>atT	p.M272I	RP11-732A19.2_ENST00000527398.1_RNA|ILK_ENST00000420936.2_Missense_Mutation_p.M272I|ILK_ENST00000537806.1_Missense_Mutation_p.M138I|ILK_ENST00000526711.1_3'UTR|ILK_ENST00000299421.4_Missense_Mutation_p.M272I|ILK_ENST00000528995.1_Missense_Mutation_p.M211I	NM_001014795.1	NP_001014795.1	Q13418	ILK_HUMAN	integrin-linked kinase	272	Protein kinase.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		CACACTGGATGCCGTATGGAT	0.517000													4	110					0.150653	0.152469	1	1	0
PHEX	5251	broad.mit.edu	37	X	22094543	22094543	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:22094543C>T	ENST00000379374.4	+	4	952	c.387C>T	c.(385-387)acC>acT	p.T129T	PHEX_ENST00000537599.1_Silent_p.T129T|PHEX_ENST00000535894.1_Silent_p.T32T	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	129					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						GGCGGGACACCGAAGCCATAC	0.388000													17	30					0	0	1	0	0
MTPN	136319	broad.mit.edu	37	7	135614721	135614721	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr7:135614721C>A	ENST00000393085.3	-	4	525	c.310G>T	c.(310-312)Gcc>Tcc	p.A104S	AC015987.1_ENST00000419211.1_RNA|MTPN_ENST00000435723.1_Missense_Mutation_p.A38S	NM_001128619.2|NM_145808.3	NP_001122091.2|NP_665807.1	P58546	MTPN_HUMAN	myotrophin	104					cell growth|regulation of striated muscle tissue development|regulation of translation	cytoplasm	protein binding	p.A104T(1)		endometrium(1)|lung(4)|prostate(1)	6						GCTTCAAAGGCGGTCAGTCCA	0.502000													16	221					4.63292e-17	5.1206e-17	1	1	0
DOK6	220164	broad.mit.edu	37	18	67406223	67406223	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr18:67406223C>T	ENST00000382713.5	+	6	812	c.622C>T	c.(622-624)Cta>Tta	p.L208L	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	208	IRS-type PTB.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				AGGAGAAGGACTATTCACTTT	0.418000													5	114					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35869709	35869709	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr9:35869709C>T	ENST00000377981.2	-	1	752	c.690G>A	c.(688-690)tcG>tcA	p.S230S		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			ACCTGGCGGCCGAGGGCACCC	0.587000													3	36					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127983808	127983808	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr7:127983808A>C	ENST00000223073.1	-	1	154	c.40T>G	c.(40-42)Tcg>Gcg	p.S14A	RBM28_ENST00000415472.2_Missense_Mutation_p.S14A	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	14	RRM 1.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						CTGCGGGCCGAGGGCGGGAGG	0.662000													3	19					0	0	1	0	0
STK19	8859	broad.mit.edu	37	6	31948281	31948281	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr6:31948281T>C	ENST00000375331.2	+	6	1023	c.857T>C	c.(856-858)cTa>cCa	p.L286P	STK19_ENST00000375333.2_Missense_Mutation_p.L290P	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	290						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						AGCTGGTGGCTAGCTGTGCCT	0.577000													3	47					0	0	1	0	0
TAZ	6901	broad.mit.edu	37	X	153641818	153641818	+	Splice_Site	SNP	G	G	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:153641818G>T	ENST00000299328.5	+	4	573		c.e4-1		TAZ_ENST00000369776.4_Splice_Site|TAZ_ENST00000351413.4_Splice_Site|TAZ_ENST00000350743.4_Splice_Site|TAZ_ENST00000369790.4_Splice_Site	NM_000116.3	NP_000107.1	Q16635	TAZ_HUMAN	tafazzin						cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCCTGCTTAGGACCCCTGCA	0.622000													31	68					3.03874e-20	3.40339e-20	1	1	0
QRICH1	54870	broad.mit.edu	37	3	49083858	49083858	+	Splice_Site	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr3:49083858C>T	ENST00000395443.2	-	5	2143	c.1671_splice	c.e5+1	p.K557_splice	QRICH1_ENST00000357496.2_Splice_Site_p.K557_splice|QRICH1_ENST00000479449.1_5'UTR|QRICH1_ENST00000424300.1_Splice_Site_p.K557_splice	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	557										breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		TGTTTCCTACCTTTTGAATAC	0.373000													8	98					0	0	1	0	0
CCDC121	79635	broad.mit.edu	37	2	27850426	27850426	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr2:27850426C>G	ENST00000324364.3	-	2	421	c.241G>C	c.(241-243)Gaa>Caa	p.E81Q	CCDC121_ENST00000394775.3_Missense_Mutation_p.E243Q|RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000556601.1_Intron	NM_024584.4	NP_078860.2	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121	81										breast(1)|endometrium(3)|large_intestine(2)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(172;0.155)					GAAATTTGTTCTGCATATCTG	0.398000													76	171					0	0	1	0	0
CTBP1-AS2	0	broad.mit.edu	37	4	1244812	1244812	+	RNA	SNP	G	G	A	rs145471382	byFrequency	TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr4:1244812G>A	ENST00000581398.1	+	0	766				CTBP1-AS2_ENST00000514984.1_RNA|CTBP1-AS2_ENST00000578730.1_RNA|CTBP1-AS2_ENST00000357591.2_RNA	NR_033339.1																						AACTGAGAACGGAGAGGGATG	0.572000													3	26					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282999	152282999	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:152282999G>A	ENST00000368799.1	-	3	4398	c.4363C>T	c.(4363-4365)Cac>Tac	p.H1455Y	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1455	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTGTCCGTGTGTGGACTCA	0.572000									Ichthyosis				7	228					0	0	1	0	0
PCDHB7	0	broad.mit.edu	37	5	140552628	140552628	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:140552628A>G	ENST00000231137.3	+	1	386	c.212A>G	c.(211-213)aAc>aGc	p.N71S		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		71	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAGACCAGAACATGCAAATT	0.493000													4	80					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43305390	43305390	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr6:43305390C>T	ENST00000361428.2	-	10	6423	c.6346G>A	c.(6346-6348)Ggc>Agc	p.G2116S	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2116					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CCCCCCAAGCCACGGTCAACA	0.468000													5	57					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32407029	32407029	+	Silent	SNP	A	A	T	rs139769264		TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:32407029A>T	ENST00000265069.8	-	6	984	c.882T>A	c.(880-882)gcT>gcA	p.A294A		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	294	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding	p.A294A(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		cagcagcagcagctgctgctg	0.483000													3	46					0	0	1	0	0
ENTPD6	0	broad.mit.edu	37	20	25187970	25187970	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr20:25187970A>T	ENST00000360031.2	+	3	492	c.310A>T	c.(310-312)Atg>Ttg	p.M104L	ENTPD6_ENST00000354989.5_Missense_Mutation_p.M88L|ENTPD6_ENST00000433259.2_Missense_Mutation_p.M105L|ENTPD6_ENST00000376652.4_Missense_Mutation_p.M105L	NM_001247.2	NP_001238.2	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	105						Golgi membrane|integral to membrane	nucleoside-diphosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|prostate(1)|skin(1)	27						CTACGGGATCATGTTTGATGC	0.662000													6	60					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52940852	52940852	+	Silent	SNP	G	G	A	rs140552770	byFrequency	TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:52940852G>A	ENST00000371544.3	-	13	2641	c.2379C>T	c.(2377-2379)caC>caT	p.H793H	ZCCHC11_ENST00000257177.4_Silent_p.H793H|ZCCHC11_ENST00000371541.1_5'UTR	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	793					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						AGTCCTGTCCGTGGTCAGCAA	0.368000													12	94					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22150181	22150181	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:22150181C>T	ENST00000374695.3	-	96	13010	c.12931G>A	c.(12931-12933)Ggt>Agt	p.G4311S	LDLRAD2_ENST00000344642.2_3'UTR|HSPG2_ENST00000486901.1_5'UTR|LDLRAD2_ENST00000543870.1_Intron	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	4311	Laminin G-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGCTCCTCACCGTCGACTTGG	0.647000													4	36					0	0	1	0	0
SLC17A2	10246	broad.mit.edu	37	6	25913553	25913553	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr6:25913553G>A	ENST00000377850.3	-	12	1953	c.1429C>T	c.(1429-1431)Cgc>Tgc	p.R477C	SLC17A2_ENST00000265425.3_3'UTR|SLC17A2_ENST00000360488.3_Silent_p.P427P			O00624	NPT3_HUMAN	solute carrier family 17, member 2	0					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity	p.P427P(2)		endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						CCTCAGAGGCGGGTAAGGGTC	0.428000													9	116					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331538	85331538	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:85331538T>C	ENST00000440886.1	-	1	304	c.266A>G	c.(265-267)aAc>aGc	p.N89S	LPAR3_ENST00000370611.3_Missense_Mutation_p.N89S|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	89					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						TGGGCCTGTGTTAAACATCAG	0.448000													51	55					0	0	1	0	0
ZNF460	10794	broad.mit.edu	37	19	57803125	57803125	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr19:57803125G>T	ENST00000360338.3	+	3	1538	c.1216G>T	c.(1216-1218)Gac>Tac	p.D406Y	ZNF460_ENST00000537645.1_Missense_Mutation_p.D365Y	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATTCGAAAAGACCTCATTCG	0.473000													18	32					7.41877e-09	7.88832e-09	1	1	0
ATP10D	57205	broad.mit.edu	37	4	47560219	47560219	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr4:47560219C>T	ENST00000273859.3	+	12	2632	c.2363C>T	c.(2362-2364)tCc>tTc	p.S788F	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	788					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CACCCTCTTTCCAATCAAGTT	0.433000													8	90					0	0	1	0	0
CMC2	56942	broad.mit.edu	37	16	81015424	81015424	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr16:81015424C>A	ENST00000219400.3	-	3	555	c.140G>T	c.(139-141)tGc>tTc	p.C47F	CMC2_ENST00000565914.1_Missense_Mutation_p.C47F|CMC2_ENST00000565925.1_Missense_Mutation_p.C47F|CMC2_ENST00000570195.1_Missense_Mutation_p.C66F|CMC2_ENST00000565108.1_Intron|CMC2_ENST00000486645.1_Intron|CMC2_ENST00000562713.1_Missense_Mutation_p.C47F|CMC2_ENST00000566231.1_5'UTR|CMC2_ENST00000564174.1_Intron|CMC2_ENST00000564249.1_Missense_Mutation_p.C47F	NM_020188.3	NP_064573.1	Q9NRP2	CP061_HUMAN	C-x(9)-C motif containing 2	47																	ATTCTTCAGGCATTTTCTCAA	0.303000													11	48					0.00185496	0.00194771	1	1	0
BNIP1	662	broad.mit.edu	37	5	172590905	172590905	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:172590905G>A	ENST00000231668.9	+	7	901	c.797G>A	c.(796-798)cGg>cAg	p.R266Q	BNIP1_ENST00000351486.5_Missense_Mutation_p.R223Q|BNIP1_ENST00000352523.6_Missense_Mutation_p.R232Q|BNIP1_ENST00000393770.4_Missense_Mutation_p.R189Q	NM_013979.2	NP_053582.2	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 1	223					anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			breast(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	11	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GTGAAAAAGCGGCTCTTTCCA	0.493000													35	85					0	0	1	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41100553	41100553	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr15:41100553C>A	ENST00000336455.5	+	2	281	c.226C>A	c.(226-228)Cca>Aca	p.P76T	ZFYVE19_ENST00000355341.4_Intron|ZFYVE19_ENST00000564258.1_Intron|ZFYVE19_ENST00000299173.10_Intron|ZFYVE19_ENST00000563530.1_Intron|ZFYVE19_ENST00000570108.1_Intron	NM_032850.4	NP_116239.3	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	244							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CACAGACCTGCCAGATTCCTC	0.542000													4	102					4.096e-09	4.41108e-09	1	1	0
CCNB1	891	broad.mit.edu	37	5	68470917	68470917	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:68470917C>T	ENST00000256442.5	+	6	1172	c.919C>T	c.(919-921)Cgg>Tgg	p.R307W		NM_031966.3	NP_114172.1	P14635	CCNB1_HUMAN	cyclin B1	307					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole				large_intestine(2)|lung(5)|skin(1)	8		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GCACTTCCTTCGGAGAGCATC	0.448000													41	79					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70612782	70612782	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:70612782C>T	ENST00000449580.1	+	20	3037	c.2986C>T	c.(2986-2988)Cgt>Tgt	p.R996C	TAF1_ENST00000373790.4_Missense_Mutation_p.R996C|TAF1_ENST00000423759.1_Missense_Mutation_p.R1017C|TAF1_ENST00000276072.3_Missense_Mutation_p.R1017C			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	996					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity	p.R996C(1)|p.R1017C(1)		breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				TGCAGACCTTCGTCGCCTTTC	0.433000													4	177					0	0	1	0	0
HDHD1	8226	broad.mit.edu	37	X	6995447	6995447	+	Silent	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:6995447G>A	ENST00000381077.5	-	3	400	c.324C>T	c.(322-324)ccC>ccT	p.P108P	HDHD1_ENST00000540122.1_Silent_p.P108P|HDHD1_ENST00000412827.2_Silent_p.P65P|HDHD1_ENST00000424830.2_Silent_p.P131P	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	108					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						CCAGTGCAAAGGGGATGCCAT	0.582000													6	56					0	0	1	0	0
UBXN6	80700	broad.mit.edu	37	19	4446151	4446151	+	Silent	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr19:4446151G>A	ENST00000301281.6	-	10	1219	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	UBXN6_ENST00000394765.3_Silent_p.F312F	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	365	UBX.					microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						CCTCCCGGACGAACCCGTACA	0.692000													8	15					0	0	1	0	0
UQCRC2	7385	broad.mit.edu	37	16	21982886	21982886	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr16:21982886T>G	ENST00000268379.4	+	9	1475	c.711T>G	c.(709-711)ttT>ttG	p.F237L	UQCRC2_ENST00000561553.1_Missense_Mutation_p.F237L	NM_003366.2	NP_003357.2	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	237					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(4)|prostate(1)|skin(1)	15				GBM - Glioblastoma multiforme(48;0.0264)		CTGAACAGTTTCTCAACATGA	0.403000													35	48					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7520964	7520964	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:7520964C>T	ENST00000338316.4	+	3	611	c.522C>T	c.(520-522)agC>agT	p.S174S		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	174					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TCGTGCTTAGCGTCTGCCTGT	0.582000													25	46					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128994350	128994350	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:128994350A>G	ENST00000274487.4	+	15	2472	c.2327A>G	c.(2326-2328)gAa>gGa	p.E776G	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	776	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTTGCAAGAGAAGATCATTGT	0.353000													8	151					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107083127	107083127	+	Silent	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr12:107083127A>G	ENST00000392842.1	+	7	1068	c.654A>G	c.(652-654)agA>agG	p.R218R	RFX4_ENST00000357881.4_Silent_p.R227R|RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000229387.5_Silent_p.R124R	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	218					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						CTGTAATAAGAGCCAACTTTG	0.413000													36	70					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118657953	118657953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:118657953G>A	ENST00000336338.5	-	4	492	c.427C>T	c.(427-429)Cga>Tga	p.R143*		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	143	Lys-rich.		R -> Q (in dbSNP:rs12133381).			cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTTCCCGTCGCTGTTGGTCC	0.418000													6	67					0	0	1	0	0
ACADVL	37	broad.mit.edu	37	17	7126528	7126528	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr17:7126528G>A	ENST00000356839.5	+	11	1333	c.1154G>A	c.(1153-1155)cGg>cAg	p.R385Q	ACADVL_ENST00000543245.2_Missense_Mutation_p.R408Q|ACADVL_ENST00000350303.5_Missense_Mutation_p.R363Q	NM_000018.3|NM_001270448.1	NP_000009.1|NP_001257377.1	P49748	ACADV_HUMAN	acyl-CoA dehydrogenase, very long chain	385	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(1)|ovary(4)|skin(1)	21						AAGCTGGCACGGATGGTTATG	0.562000													5	132					0	0	1	0	0
WDR91	29062	broad.mit.edu	37	7	134891927	134891927	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr7:134891927G>A	ENST00000354475.4	-	4	570	c.539C>T	c.(538-540)gCg>gTg	p.A180V	WDR91_ENST00000423565.1_Missense_Mutation_p.A145V|WDR91_ENST00000344400.5_Missense_Mutation_p.A180V	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	180								p.A180V(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						CTGACACTCCGCATCAAAGTT	0.458000													4	86					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19630776	19630776	+	Silent	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:19630776A>G	ENST00000235835.3	-	7	1044	c.1023T>C	c.(1021-1023)gaT>gaC	p.D341D		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	341					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GATTAAAGGCATCCACGACAG	0.597000													4	53					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31809579	31809579	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr10:31809579A>G	ENST00000446923.2	+	7	1659	c.1268A>G	c.(1267-1269)aAa>aGa	p.K423R	ZEB1_ENST00000361642.5_Missense_Mutation_p.K440R|ZEB1_ENST00000320985.10_Missense_Mutation_p.K439R|ZEB1_ENST00000542815.3_Missense_Mutation_p.K372R|ZEB1_ENST00000560721.2_Missense_Mutation_p.K419R|ZEB1_ENST00000559858.1_3'UTR	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	439					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CTTGCATCCAAAGAACAAGAA	0.373000													3	70					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998610	27998610	+	Missense_Mutation	SNP	C	C	T	rs146103278		TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:27998610C>T	ENST00000441525.1	-	1	956	c.842G>A	c.(841-843)cGt>cAt	p.R281H		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	281										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						CTTGGCCACACGCTTAGTATT	0.498000													9	86					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12905355	12905355	+	Silent	SNP	T	T	C			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:12905355T>C	ENST00000380659.3	+	3	1867	c.1728T>C	c.(1726-1728)aaT>aaC	p.N576N		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	576					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	TAAGCAGTAATAGCCATTATT	0.373000													4	275					0	0	1	0	0
IQCC	55721	broad.mit.edu	37	1	32671760	32671760	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:32671760C>T	ENST00000537469.1	+	2	335	c.288C>T	c.(286-288)tgC>tgT	p.C96C	RP4-622L5.7_ENST00000421616.1_RNA|IQCC_ENST00000291358.6_Silent_p.C16C|RP4-622L5.7_ENST00000373604.4_RNA	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	16										endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCAGGCCTGCGTCCGGGGCT	0.602000													4	73					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													3	15					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123811091	123811091	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr11:123811091C>T	ENST00000307033.2	+	1	842	c.768C>T	c.(766-768)taC>taT	p.Y256Y		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTTGCATCTACGTCTATACAA	0.532000													10	151					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47809221	47809221	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr21:47809221C>T	ENST00000359568.5	+	19	3822	c.3715C>T	c.(3715-3717)Cgt>Tgt	p.R1239C	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1239					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CAGCCACATGCGTGAAAGCTT	0.572000													5	96					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101090887	101090887	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr3:101090887C>T	ENST00000394095.2	-	7	814	c.761G>A	c.(760-762)gGc>gAc	p.G254D	SENP7_ENST00000394091.1_Missense_Mutation_p.G90D|SENP7_ENST00000348610.3_Missense_Mutation_p.G221D|SENP7_ENST00000394094.2_Missense_Mutation_p.G189D|SENP7_ENST00000358203.3_Missense_Mutation_p.G90D|SENP7_ENST00000314261.7_Missense_Mutation_p.G188D	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	254					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AAGAGAAATGCCATCATCCTT	0.343000													11	77					0	0	1	0	0
METTL13	51603	broad.mit.edu	37	1	171765758	171765758	+	Silent	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:171765758G>A	ENST00000361735.3	+	8	2228	c.1962G>A	c.(1960-1962)ctG>ctA	p.L654L	METTL13_ENST00000466643.1_3'UTR|METTL13_ENST00000362019.3_Silent_p.L568L|METTL13_ENST00000367737.5_Silent_p.L498L|METTL13_ENST00000458517.1_Silent_p.L653L	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	654							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						TCTGTCAGCTGCACCCTGAGC	0.557000													36	76					0	0	1	0	0
OR4S1	256148	broad.mit.edu	37	11	48328584	48328584	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr11:48328584C>T	ENST00000319988.1	+	1	810	c.810C>T	c.(808-810)atC>atT	p.I270I		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						AACTTATCATCCTCTTTAACA	0.458000													34	81					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31632836	31632836	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr12:31632836C>T	ENST00000389082.5	-	3	855	c.591G>A	c.(589-591)ccG>ccA	p.P197P	DENND5B_ENST00000306833.6_Silent_p.P232P|DENND5B_ENST00000536562.1_Silent_p.P232P|DENND5B_ENST00000545147.1_Intron|DENND5B_ENST00000354285.4_Silent_p.P219P	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	197	DENN.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						TGAATGGTAACGGTGTGATCA	0.433000													15	34					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42011989	42011989	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr7:42011989A>G	ENST00000395925.3	-	13	2134	c.2050T>C	c.(2050-2052)Tca>Cca	p.S684P	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	684					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TCCCGCTTTGAGGTAGTGTTG	0.562000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				11	143					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44035429	44035429	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:44035429G>A	ENST00000359947.4	+	6	888	c.548G>A	c.(547-549)cGc>cAc	p.R183H	PTPRF_ENST00000438120.1_Missense_Mutation_p.R183H|PTPRF_ENST00000372413.3_Missense_Mutation_p.R183H|PTPRF_ENST00000372414.3_Missense_Mutation_p.R183H	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	183	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGCAACGGCCGCATCAAGCAG	0.587000													3	26					0	0	1	0	0
LRP2BP	55805	broad.mit.edu	37	4	186295495	186295495	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr4:186295495G>A	ENST00000362004.3	-	4	1268	c.457C>T	c.(457-459)Cga>Tga	p.R153*	RP11-714G18.1_ENST00000514884.1_RNA|LRP2BP_ENST00000510776.1_Nonsense_Mutation_p.R125*|LRP2BP_ENST00000505916.1_Nonsense_Mutation_p.R151*|LRP2BP_ENST00000328559.7_Nonsense_Mutation_p.R151*			Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	151						cytoplasm	protein binding			breast(1)|endometrium(2)|large_intestine(6)|lung(3)|prostate(1)|skin(2)	15		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		TCATTTGATCGTTTAACACCT	0.388000													5	75					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233349567	233349567	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr2:233349567C>T	ENST00000304546.1	-	5	1213	c.1003G>A	c.(1003-1005)Gtc>Atc	p.V335I	ECEL1_ENST00000409941.1_Missense_Mutation_p.V335I	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	335					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		ATGGAGCTGACATCTCGCCGT	0.612000													6	56					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28651576	28651576	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr18:28651576A>C	ENST00000280904.6	-	13	2563	c.2120T>G	c.(2119-2121)cTc>cGc	p.L707R	DSC2_ENST00000251081.6_Missense_Mutation_p.L707R	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	707					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CTTACAAAAGAGCAATGCTAT	0.413000													3	49					0	0	1	0	0
IDH2	3418	broad.mit.edu	37	15	90631838	90631838	+	Missense_Mutation	SNP	C	C	T	rs121913503		TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr15:90631838C>T	ENST00000330062.3	-	4	628	c.515G>A	c.(514-516)aGg>aAg	p.R172K	IDH2_ENST00000539790.1_Missense_Mutation_p.R42K|IDH2_ENST00000540499.2_Missense_Mutation_p.R120K|IDH2_ENST00000559482.1_Intron	NM_002168.2	NP_002159.2	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+), mitochondrial	172					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(116)|p.R172M(21)|p.R172N(1)		biliary_tract(11)|bone(19)|central_nervous_system(107)|endometrium(1)|haematopoietic_and_lymphoid_tissue(953)|large_intestine(8)|lung(5)|skin(5)	1109	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			ATGGGCGTGCCTGCCAATGGT	0.632000			M		GBM								19	48					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176316702	176316702	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:176316702C>T	ENST00000292432.5	-	7	765	c.674G>A	c.(673-675)gGc>gAc	p.G225D		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	225	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATCATGGTGCCCACTGTGTC	0.587000													6	49					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4905406	4905406	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr17:4905406C>T	ENST00000320785.5	+	6	773	c.416C>T	c.(415-417)tCc>tTc	p.S139F		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	139	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						GCTCAGCTATCCTACTCTGTG	0.572000													6	106					0	0	1	0	0
CYP4Z2P	0	broad.mit.edu	37	1	47325399	47325399	+	RNA	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr1:47325399G>A	ENST00000505841.1	-	0	1130					NR_002788.2																						CTACCGGTGCGTAGAGGCGGA	0.473000													4	58					0	0	1	0	0
SLC2A14	144195	broad.mit.edu	37	12	7984361	7984361	+	Splice_Site	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr12:7984361C>T	ENST00000543909.1	-	9	940		c.e9-1		SLC2A14_ENST00000431042.2_Splice_Site|SLC2A14_ENST00000396589.2_Splice_Site|SLC2A14_ENST00000539924.1_Splice_Site|SLC2A14_ENST00000542546.1_Intron|SLC2A14_ENST00000535295.1_Intron|SLC2A14_ENST00000542505.1_Intron|SLC2A14_ENST00000340749.5_Splice_Site			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14						cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		CCTTTATGATCTGCAAAATAA	0.448000											OREG0021654	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	44					0	0	1	0	0
ILVBL	10994	broad.mit.edu	37	19	15227282	15227282	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr19:15227282G>T	ENST00000263383.3	-	11	1377	c.1238C>A	c.(1237-1239)aCc>aAc	p.T413N	ILVBL_ENST00000534378.1_Missense_Mutation_p.T306N	NM_006844.3	NP_006835.2	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	413						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)	26						TGGGGCCCAGGTCTGGCCCTG	0.637000													3	61					0.0215528	0.0220784	1	1	0
UGGT1	56886	broad.mit.edu	37	2	128941352	128941352	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr2:128941352A>G	ENST00000375990.3	+	38	4679	c.4276A>G	c.(4276-4278)Aat>Gat	p.N1426D	UGGT1_ENST00000259253.6_Missense_Mutation_p.N1450D			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1450	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CAGCCTTTCAAATCTTGATCA	0.413000													12	21					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62291171	62291171	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr17:62291171G>A	ENST00000258991.3	-	2	491	c.407C>T	c.(406-408)cCa>cTa	p.P136L	TEX2_ENST00000583097.1_Missense_Mutation_p.P136L|TEX2_ENST00000584379.1_Missense_Mutation_p.P136L			Q8IWB9	TEX2_HUMAN	testis expressed 2	136					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AGACGACCCTGGGGACACAGC	0.537000													39	85					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101075815	101075815	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr8:101075815G>A	ENST00000360863.6	-	8	1375	c.1181C>T	c.(1180-1182)cCa>cTa	p.P394L	RGS22_ENST00000523437.1_Missense_Mutation_p.P382L|RGS22_ENST00000523287.1_Missense_Mutation_p.P213L	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	394					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CCTGCTCTCTGGTCCAGCGCT	0.368000													11	95					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99662020	99662020	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr7:99662020C>T	ENST00000292450.4	+	4	1366	c.1202C>T	c.(1201-1203)gCg>gTg	p.A401V	ZSCAN21_ENST00000543588.1_Missense_Mutation_p.R367W|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.R367W|ZNF3_ENST00000413658.2_3'UTR	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	401					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AGTCAGCATGCGGGCCTCAGC	0.522000													4	120					0	0	1	0	0
NYX	60506	broad.mit.edu	37	X	41333636	41333636	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:41333636C>T	ENST00000342595.2	+	2	1386	c.930C>T	c.(928-930)aaC>aaT	p.N310N	NYX_ENST00000378220.1_Silent_p.N310N	NM_022567.2	NP_072089.1	Q9GZU5	NYX_HUMAN	nyctalopin	310					response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(11)|upper_aerodigestive_tract(1)	17						TGCACCTCAACGGCAACCGCC	0.677000													22	60					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102519070	102519070	+	Silent	SNP	T	T	C			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:102519070T>C	ENST00000321521.9	+	25	3631	c.3058T>C	c.(3058-3060)Ttg>Ctg	p.L1020L	PPIP5K2_ENST00000358359.3_Silent_p.L1020L|PPIP5K2_ENST00000414217.1_Silent_p.L1020L|PPIP5K2_ENST00000513500.1_3'UTR			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	1020					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CCCCAAATCATTGGCTTTCAC	0.453000													25	77					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38790794	38790794	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr6:38790794G>A	ENST00000359357.3	+	25	3307	c.3053G>A	c.(3052-3054)cGc>cAc	p.R1018H	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1235H|DNAH8_ENST00000441566.1_Missense_Mutation_p.R1018H					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACAGAGGACCGCGATGTGAAA	0.453000													23	39					0	0	1	0	0
OPN1MW	2652	broad.mit.edu	37	X	153459015	153459015	+	Silent	SNP	C	C	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:153459015C>T	ENST00000369935.5	+	5	921	c.861C>T	c.(859-861)ttC>ttT	p.F287F		NM_000513.2	NP_000504.1	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	287					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|lung(1)	2	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACGCCTTCTTCGCATGCTTTG	0.562000													18	153					0	0	1	0	0
REPS1	85021	broad.mit.edu	37	6	139264996	139264996	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr6:139264996T>G	ENST00000450536.2	-	6	1484	c.910A>C	c.(910-912)Att>Ctt	p.I304L	REPS1_ENST00000415951.2_Missense_Mutation_p.I304L|REPS1_ENST00000258062.5_Missense_Mutation_p.I304L|REPS1_ENST00000409812.2_Missense_Mutation_p.I304L|REPS1_ENST00000367663.4_Missense_Mutation_p.I304L			Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	304	EH 2.					coated pit|plasma membrane	calcium ion binding|SH3 domain binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	19				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TCACCTGGAATAAATCCGTTT	0.328000													21	47					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	79950742	79950750	+	In_Frame_Del	DEL	CCCCCAGCT	CCCCCAGCT	-	rs3045983		TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr5:79950742_79950750delCCCCCAGCT	ENST00000265081.6	+	1	276_284	c.196_204delCCCCCAGCT	c.(196-204)del	p.PPA66del	DHFR_ENST00000439211.2_5'UTR	NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	66					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		gCCCCCAGCGCCCCCAGCTCCCGCCTTCC	0.732								Mismatch excision repair (MMR)					4	7	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46320707	46320708	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr12:46320707_46320708delTC	ENST00000465950.1	-	1	3040_3041	c.1831_1832delGA	c.(1831-1833)afs	p.E611fs	SCAF11_ENST00000419565.2_Frame_Shift_Del_p.E926fs|SCAF11_ENST00000369367.3_Frame_Shift_Del_p.E926fs|SCAF11_ENST00000549162.1_Frame_Shift_Del_p.E734fs			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	926					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GGTTCTCCTTTCTCTCTCTCTC	0.446													8	237	---	---	---	---					
AE000661.37	0	broad.mit.edu	37	14	22933391	22933391	+	RNA	DEL	C	C	-	rs36090939		TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr14:22933391delC	ENST00000514473.2	-	0	225				TRDC_ENST00000390477.2_RNA|AE000661.37_ENST00000556777.1_RNA																							TTAGAAATGGCTAAGAAACCA	0.408													2	4	---	---	---	---					
BTBD7	55727	broad.mit.edu	37	14	93761192	93761193	+	Frame_Shift_Ins	INS	-	-	T			TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr14:93761192_93761193insT	ENST00000334746.5	-	3	480_481	c.173_174insA	c.(172-174)aagfs	p.K58fs	BTBD7_ENST00000298896.3_Frame_Shift_Ins_p.K58fs|BTBD7_ENST00000555525.1_Frame_Shift_Ins_p.K58fs|BTBD7_ENST00000554565.1_Intron	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	58								p.K58fs*44(2)|p.R59fs*14(2)		breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		CAGAGGTTCTCTTTTTTTTGTC	0.441													7	223	---	---	---	---					
ZNF559	84527	broad.mit.edu	37	19	9452027	9452028	+	Frame_Shift_Del	DEL	CT	CT	-	rs55837495		TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chr19:9452027_9452028delCT	ENST00000592504.1	+	6	665_666	c.410_411delCT	c.(409-411)afs	p.T137fs	ZNF177_ENST00000602738.1_Intron|ZNF559_ENST00000587557.1_Intron|ZNF559_ENST00000585352.1_Intron|ZNF559_ENST00000592896.1_Intron|ZNF177_ENST00000541595.2_Intron|ZNF559_ENST00000393883.2_Intron|ZNF559_ENST00000538743.1_Intron|ZNF559_ENST00000586255.1_Intron|ZNF177_ENST00000446085.4_Intron|ZNF177_ENST00000605471.1_Intron|ZNF559_ENST00000317221.7_Intron|ZNF559_ENST00000603380.1_Intron|ZNF177_ENST00000602856.1_Intron			Q9BR84	ZN559_HUMAN	zinc finger protein 559	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						TTGACAAACACTCTAAACATCC	0.347													3	3	---	---	---	---					
FTX	0	broad.mit.edu	37	X	73506653	73506654	+	RNA	INS	-	-	A	rs149262205		TCGA-S9-A7QY-01A-11D-A34A-08	TCGA-S9-A7QY-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3b118d0f-04ee-4217-952b-9c720413fb1a	51e0f1be-6e26-4b2e-b79e-731ec9b5c4d8	g.chrX:73506653_73506654insA	ENST00000429124.1	-	0	174																											acctgtcccttaaaaaaaaaaa	0.455													3	3	---	---	---	---					
