Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TLN1	7094	broad.mit.edu	37	9	35720836	35720836	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr9:35720836G>A	ENST00000314888.9	-	11	1532	c.1179C>T	c.(1177-1179)gcC>gcT	p.A393A	TLN1_ENST00000540444.1_Silent_p.A393A	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	393	FERM.|Interaction with LAYN (By similarity).				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CGATGTAGCCGGCAATGAGCT	0.507000													32	130					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219878294	219878294	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr2:219878294C>T	ENST00000341552.5	-	23	3876	c.3793G>A	c.(3793-3795)Ggt>Agt	p.G1265S	CCDC108_ENST00000441968.1_Missense_Mutation_p.G1265S|CCDC108_ENST00000453220.1_Missense_Mutation_p.G1265S|AC097468.4_ENST00000441450.1_RNA	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1265						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGATCAGTACCGATGAACAGG	0.542000													3	12					0	0	1	0	0
KRT20	54474	broad.mit.edu	37	17	39041252	39041252	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr17:39041252G>A	ENST00000167588.3	-	1	227	c.186C>T	c.(184-186)ggC>ggT	p.G62G		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	62	Head.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				ACAGGTCCCCGCCGCCTGTGA	0.577000													4	180					0	0	1	0	0
IDH2	3418	broad.mit.edu	37	15	90631838	90631838	+	Missense_Mutation	SNP	C	C	T	rs121913503		TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr15:90631838C>T	ENST00000330062.3	-	4	628	c.515G>A	c.(514-516)aGg>aAg	p.R172K	IDH2_ENST00000539790.1_Missense_Mutation_p.R42K|IDH2_ENST00000540499.2_Missense_Mutation_p.R120K|IDH2_ENST00000559482.1_Intron	NM_002168.2	NP_002159.2	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+), mitochondrial	172					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(116)|p.R172M(21)|p.R172N(1)		biliary_tract(11)|bone(19)|central_nervous_system(107)|endometrium(1)|haematopoietic_and_lymphoid_tissue(953)|large_intestine(8)|lung(5)|skin(5)	1109	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			ATGGGCGTGCCTGCCAATGGT	0.632000			M		GBM								44	43					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114541285	114541285	+	Missense_Mutation	SNP	T	T	G			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chrX:114541285T>G	ENST00000371920.3	+	4	865	c.858T>G	c.(856-858)gaT>gaG	p.D286E	LUZP4_ENST00000451986.2_Missense_Mutation_p.D204E	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	286						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						CTGAGAGAGATCTCATAAATC	0.418000													4	135					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129812402	129812402	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr11:129812402C>A	ENST00000358825.5	-	7	1116	c.885G>T	c.(883-885)gaG>gaT	p.E295D	PRDM10_ENST00000528746.1_Missense_Mutation_p.E269D|PRDM10_ENST00000526082.1_Missense_Mutation_p.E209D|PRDM10_ENST00000360871.3_Missense_Mutation_p.E295D|PRDM10_ENST00000304538.6_Missense_Mutation_p.E209D|PRDM10_ENST00000423662.2_Missense_Mutation_p.E209D	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	295	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CCAGGTTCTGCTCCAGGTGAT	0.473000													4	254					0.150653	0.150653	1	1	0
UNK	85451	broad.mit.edu	37	17	73814838	73814838	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr17:73814838G>A	ENST00000293218.3	+	12	1715	c.1715G>A	c.(1714-1716)gGc>gAc	p.G572D	UNK_ENST00000589666.1_Missense_Mutation_p.G496D			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	496							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGCGTCCCCGGCATGAATGCA	0.597000													4	61					0	0	1	0	0
ATG4A	115201	broad.mit.edu	37	X	107381181	107381181	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chrX:107381181G>A	ENST00000372232.3	+	8	854	c.695G>A	c.(694-696)gGc>gAc	p.G232D	ATG4A_ENST00000545696.1_Intron|ATG4A_ENST00000372254.3_Missense_Mutation_p.G208D|ATG4A_ENST00000345734.3_Intron	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	232					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity	p.G232D(2)		endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						CTTCGCCTGGGCATAAACCAA	0.522000													5	295					0	0	1	0	0
MLST8	64223	broad.mit.edu	37	16	2258498	2258498	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr16:2258498C>T	ENST00000569417.1	+	8	1100	c.746C>T	c.(745-747)aCg>aTg	p.T249M	MLST8_ENST00000301725.7_3'UTR|MLST8_ENST00000565250.1_Missense_Mutation_p.T249M|MLST8_ENST00000564088.1_Missense_Mutation_p.T249M|MLST8_ENST00000382450.4_Missense_Mutation_p.T248M|MLST8_ENST00000397124.1_Missense_Mutation_p.T249M|MLST8_ENST00000301724.10_Missense_Mutation_p.T249M	NM_022372.4	NP_071767.3	Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	249					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding			large_intestine(3)|lung(2)|skin(1)	6						ATCTGGAGGACGTCCAACTTC	0.662000													7	195					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40655853	40655853	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr15:40655853G>A	ENST00000267889.3	+	2	234	c.147G>A	c.(145-147)gaG>gaA	p.E49E		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	49					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TGCCCCCTGAGGCAAGCCCAG	0.622000													28	120					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414313	20414313	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr9:20414313G>A	ENST00000380338.4	-	5	817	c.531C>T	c.(529-531)agC>agT	p.S177S	MLLT3_ENST00000429426.2_Silent_p.S174S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	177	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								7	247					0	0	1	0	0
PHYH	5264	broad.mit.edu	37	10	13337514	13337514	+	Missense_Mutation	SNP	G	G	A	rs141855372	byFrequency	TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr10:13337514G>A	ENST00000396920.3	-	3	574	c.170C>T	c.(169-171)gCc>gTc	p.A57V	PHYH_ENST00000396913.2_5'UTR|PHYH_ENST00000263038.4_Missense_Mutation_p.A76V			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	76					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TTGAATATCGGCATCAGGTAC	0.353000													5	322					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803702	142803702	+	RNA	SNP	A	A	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr1:142803702A>T	ENST00000423385.1	-	0	1263																											ccatcataacatctgtgttcc	0.338000													4	51					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	59284439	59284439	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr5:59284439G>A	ENST00000502484.2	-	3	371	c.148C>T	c.(148-150)Cct>Tct	p.P50S	PDE4D_ENST00000546160.1_Missense_Mutation_p.P50S	NM_001165899.1	NP_001159371.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	0	Pro-rich.				signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	AAGGCGAGAGGGGGAAGCTGA	0.488000													104	186					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31332565	31332565	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr22:31332565T>C	ENST00000215862.4	-	18	2847	c.1484A>G	c.(1483-1485)cAg>cGg	p.Q495R	MORC2_ENST00000469915.1_5'UTR|MORC2_ENST00000397641.2_Missense_Mutation_p.Q557R	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	557							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						CTTCTCTTCCTGCGTCTTCAT	0.517000													104	156					0	0	1	0	0
IGLV9-49	0	broad.mit.edu	37	22	22697799	22697799	+	RNA	SNP	A	A	C			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr22:22697799A>C	ENST00000427632.2	+	0	124																											CACCTTCTGCATCAGCCTCCC	0.597000											OREG0026357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	65					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36271878	36271878	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr19:36271878C>T	ENST00000007510.4	+	11	1030	c.886C>T	c.(886-888)Cgc>Tgc	p.R296C	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.R160C|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.R296C			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	296					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CATGCGCTCCCGCCCTTCTCG	0.667000													4	93					0	0	1	0	0
FOLR4	390243	broad.mit.edu	37	11	94038918	94038918	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr11:94038918C>T	ENST00000440961.2	+	1	160	c.116C>T	c.(115-117)cCa>cTa	p.P39L		NM_001199206.1	NP_001186135.1	A6ND01	FOLR4_HUMAN	folate receptor 4, delta (putative)	39						extracellular region	folic acid binding|receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14						GTGCCCAGCCCAGAAGACAAG	0.567000													32	33					0	0	1	0	0
PCDHA2	0	broad.mit.edu	37	5	140176258	140176258	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr5:140176258C>T	ENST00000526136.1	+	1	1709	c.1709C>T	c.(1708-1710)gCt>gTt	p.A570V	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.A570V|PCDHA2_ENST00000520672.2_Missense_Mutation_p.A570V	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCCTAGGGCTGGCACCGCT	0.697000													5	191					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24918463	24918463	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr16:24918463G>A	ENST00000347898.3	+	12	1854	c.1232G>A	c.(1231-1233)cGg>cAg	p.R411Q	SLC5A11_ENST00000424767.2_Missense_Mutation_p.R376Q|SLC5A11_ENST00000567758.1_Missense_Mutation_p.R376Q|SLC5A11_ENST00000449109.2_Missense_Mutation_p.R255Q|SLC5A11_ENST00000568579.1_Missense_Mutation_p.R341Q|SLC5A11_ENST00000569071.1_Missense_Mutation_p.R255Q|SLC5A11_ENST00000539472.1_Missense_Mutation_p.R347Q|SLC5A11_ENST00000545376.1_Missense_Mutation_p.R341Q|SLC5A11_ENST00000565769.1_Missense_Mutation_p.R347Q	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	411					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		CTCCGGCCTCGGGCATCTGAG	0.597000													110	164					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947747	57947747	+	Silent	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr11:57947747C>T	ENST00000335397.3	+	3	1147	c.831C>T	c.(829-831)taC>taT	p.Y277Y		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				CTGTGCTTTACACAGAGGTCA	0.468000													53	119					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72968063	72968063	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr8:72968063C>T	ENST00000262209.4	-	11	1429	c.1222G>A	c.(1222-1224)Gat>Aat	p.D408N	RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	408						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TTGTCTTCATCCATTACCAGC	0.368000													49	57					0	0	1	0	0
AURKA	6790	broad.mit.edu	37	20	54945296	54945296	+	Missense_Mutation	SNP	A	A	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr20:54945296A>T	ENST00000395909.4	-	11	1695	c.1130T>A	c.(1129-1131)gTa>gAa	p.V377E	AURKA_ENST00000371356.2_Missense_Mutation_p.V377E|AURKA_ENST00000347343.2_Missense_Mutation_p.V377E|AURKA_ENST00000395915.3_Missense_Mutation_p.V377E|AURKA_ENST00000312783.6_Missense_Mutation_p.V377E|AURKA_ENST00000395911.1_Missense_Mutation_p.V377E|AURKA_ENST00000395907.1_3'UTR|AURKA_ENST00000395913.3_Missense_Mutation_p.V377E|AURKA_ENST00000395914.1_Missense_Mutation_p.V377E	NM_198433.1	NP_940835.1	O14965	AURKA_HUMAN	aurora kinase A	377	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|lung(9)|ovary(2)|prostate(1)|skin(2)	22			Colorectal(105;0.202)			GTGTTCAAGTACTTCTCTGAG	0.453000													6	351					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202246	248202246	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr1:248202246G>A	ENST00000366479.2	+	1	773	c.677G>A	c.(676-678)cGc>cAc	p.R226H	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R226L(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCTGTCTACCGCATGCACTCT	0.483000													5	352					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94248550	94248550	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr5:94248550G>A	ENST00000515393.1	-	9	1481	c.1482C>T	c.(1480-1482)taC>taT	p.Y494Y	MCTP1_ENST00000505078.1_Silent_p.Y10Y|MCTP1_ENST00000505208.1_Silent_p.Y273Y|MCTP1_ENST00000429576.2_Silent_p.Y227Y|MCTP1_ENST00000312216.8_Silent_p.Y273Y	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	494	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		GGAACTTCACGTAGGGATCGC	0.468000													5	234					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30946435	30946435	+	Missense_Mutation	SNP	C	C	G			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr8:30946435C>G	ENST00000298139.5	+	13	1855	c.1606C>G	c.(1606-1608)Caa>Gaa	p.Q536E		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	536					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CAATGAAGAGCAAGTTACTTG	0.328000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				36	51					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149485858	149485858	+	RNA	SNP	A	A	G			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr7:149485858A>G	ENST00000378016.2	+	0	4077							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGGAAGGTCAATGGCATTGTG	0.622000													31	62					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724449	138724449	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr3:138724449C>T	ENST00000383163.2	-	1	661	c.662G>A	c.(661-663)cGc>cAc	p.R221H		NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	221	Pro-rich.									endometrium(3)|kidney(1)|lung(7)	11						CTCCAGAAGGCGGAATTCCGG	0.682000													21	21					0	0	1	0	0
ABCB10	23456	broad.mit.edu	37	1	229676423	229676423	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr1:229676423G>A	ENST00000344517.4	-	5	1175	c.1133C>T	c.(1132-1134)gCc>gTc	p.A378V		NM_012089.2	NP_036221.2	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 10	378	ABC transmembrane type-1.					integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)	31	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				CACTTTGCTGGCATATTTCTC	0.403000													4	202					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116435002	116435002	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr12:116435002G>A	ENST00000281928.3	-	15	2809	c.2603C>T	c.(2602-2604)cCa>cTa	p.P868L		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	868					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CAAAGATGGTGGAGTGGGAAA	0.398000													4	234					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95121241	95121241	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr13:95121241G>A	ENST00000377028.5	-	2	767	c.354C>T	c.(352-354)tgC>tgT	p.C118C	DCT_ENST00000446125.1_Silent_p.C118C	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	118					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TCTTCCGCTCGCAGTTGGGAC	0.498000													11	390					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187329	123187329	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr12:123187329G>A	ENST00000328880.5	-	1	561	c.502C>T	c.(502-504)Ccg>Tcg	p.P168S	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	168					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	TTCTGGATCGGCATCTTCTTC	0.542000													4	152					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17531148	17531148	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr11:17531148C>T	ENST00000005226.7	-	18	1767	c.1768G>A	c.(1768-1770)Gcc>Acc	p.A590T	USH1C_ENST00000318024.4_Intron|USH1C_ENST00000529563.1_Intron|USH1C_ENST00000527720.1_Intron|USH1C_ENST00000527020.1_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						GAGGATGAGGCGCTCACATGG	0.672000													8	27					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791718	42791718	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr19:42791718C>T	ENST00000572681.2	+	6	3399	c.3331C>T	c.(3331-3333)Cgg>Tgg	p.R1111W	CIC_ENST00000160740.3_Missense_Mutation_p.R202W|CIC_ENST00000575354.2_Missense_Mutation_p.R202W			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	202	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.R202W(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CCACATCCGGCGGCCCATGAA	0.622000			"""Mis, F, S"""		oligodendroglioma								41	30					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			55	118					0	0	1	0	0
C1orf101	257044	broad.mit.edu	37	1	244756809	244756809	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr1:244756809G>A	ENST00000366534.4	+	17	2286	c.2232G>A	c.(2230-2232)agG>agA	p.R744R	C1orf101_ENST00000366533.4_Silent_p.R744R|C1orf101_ENST00000473875.1_3'UTR|C1orf101_ENST00000366531.3_Silent_p.R593R	NM_001130957.1	NP_001124429.1	Q5SY80	CA101_HUMAN	chromosome 1 open reading frame 101	744						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	36	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			AGAGAGTAAGGTATATTTGGG	0.348000													67	98					0	0	1	0	0
HPX	3263	broad.mit.edu	37	11	6452914	6452914	+	Silent	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr11:6452914C>T	ENST00000265983.3	-	9	1186	c.1086G>A	c.(1084-1086)gcG>gcA	p.A362A		NM_000613.2	NP_000604.1	P02790	HEMO_HUMAN	hemopexin	362					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(11)|prostate(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		AGATAAAGGCCGCATCCACAG	0.557000													80	108					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902292	1902292	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr20:1902292G>A	ENST00000358771.4	+	3	840	c.688G>A	c.(688-690)Gtg>Atg	p.V230M	SIRPA_ENST00000356025.3_Missense_Mutation_p.V230M|SIRPA_ENST00000400068.3_Missense_Mutation_p.V230M	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	230	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V230M(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		CATCTGCGAGGTGGCCCACGT	0.612000													4	121					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37414310	37414310	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr22:37414310G>T	ENST00000403892.3	-	1	1198	c.464C>A	c.(463-465)gCc>gAc	p.A155D	TST_ENST00000249042.3_Missense_Mutation_p.A155D	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	155	Hinge.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						GTCCAGTGTGGCTTTGAAGAC	0.597000													25	52					2.48779e-11	2.57826e-11	1	1	0
RP11-783K16.14	0	broad.mit.edu	37	11	63997583	63997583	+	RNA	SNP	A	A	C			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr11:63997583A>C	ENST00000534988.1	-	0	99																											AAAAAAAAAAACCCGCCCAGC	0.532000													4	3					0	0	1	0	0
AQP10	89872	broad.mit.edu	37	1	154293680	154293680	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr1:154293680C>T	ENST00000484864.1	+	1	85	c.49C>T	c.(49-51)Cgc>Tgc	p.R17C	AQP10_ENST00000324978.3_Missense_Mutation_p.R17C|AQP10_ENST00000355197.4_3'UTR			Q96PS8	AQP10_HUMAN	aquaporin 10	17					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCTCCGGATACGCAGCCTCCT	0.567000													34	106					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195515463	195515463	+	Silent	SNP	G	G	A			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr3:195515463G>A	ENST00000463781.3	-	2	3447	c.2988C>T	c.(2986-2988)acC>acT	p.T996T	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Silent_p.T996T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1001	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T996T(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGCATCGGTGACATGAA	0.582000													4	26					0	0	1	0	0
GML	2765	broad.mit.edu	37	8	143928001	143928001	+	Silent	SNP	C	C	T			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr8:143928001C>T	ENST00000220940.1	+	4	462	c.372C>T	c.(370-372)ccC>ccT	p.P124P		NM_002066.2	NP_002057.1	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule like	124	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane		p.P124P(1)		NS(1)|central_nervous_system(2)|endometrium(1)|large_intestine(6)|lung(8)	18	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACATGTTACCCGATGAAGTAA	0.418000													5	218					0	0	1	0	0
TRIM23	373	broad.mit.edu	37	5	64892881	64892881	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr5:64892881T>C	ENST00000231524.9	-	8	1677	c.1306A>G	c.(1306-1308)Att>Gtt	p.I436V	TRIM23_ENST00000381018.3_Missense_Mutation_p.I436V|TRIM23_ENST00000274327.7_Missense_Mutation_p.I436V	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	436	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		TACTTACCAATTGTTGGAATG	0.388000													70	185					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52860815	52860815	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr3:52860815delG	ENST00000266041.4	-	4	607	c.511delC	c.(511-513)acfs	p.H171fs	ITIH4_ENST00000406595.1_Frame_Shift_Del_p.H171fs|ITIH4_ENST00000485816.1_Frame_Shift_Del_p.H171fs|ITIH4_ENST00000434759.3_Frame_Shift_Del_p.H83fs|ITIH4_ENST00000346281.5_Frame_Shift_Del_p.H171fs	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	171					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		ACCTGCAGGTGCTTGACCAGC	0.622													41	69	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74227325	74227325	+	RNA	DEL	C	C	-	rs146363494		TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr5:74227325delC	ENST00000505200.1	-	0	335																											cagagaattgcttgaacccag	0.463													2	4	---	---	---	---					
BTN2A3P	0	broad.mit.edu	37	6	26428451	26428451	+	RNA	DEL	A	A	-	rs139821417		TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr6:26428451delA	ENST00000466808.2	+	0	1304																											gtgtctaattaaaaaaaaaaa	0.448													2	4	---	---	---	---					
FGFBP3	143282	broad.mit.edu	37	10	93668353	93668353	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr10:93668353delT	ENST00000311575.5	-	2	537	c.374delA	c.(373-375)ccfs	p.H125fs		NM_152429.4	NP_689642.3	Q8TAT2	FGFP3_HUMAN	fibroblast growth factor binding protein 3	125					positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of vascular permeability	extracellular region	fibroblast growth factor binding|heparin binding			large_intestine(1)|prostate(1)	2		Colorectal(252;0.162)				CGCGGGGTCGTGACAGGGCCT	0.761													2	4	---	---	---	---					
HERC2P2	0	broad.mit.edu	37	15	23312380	23312380	+	RNA	DEL	T	T	-			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr15:23312380delT	ENST00000560464.1	-	0	3118																											TGTTAttttcttttttttttt	0.398													3	5	---	---	---	---					
GINS1	9837	broad.mit.edu	37	20	25422397	25422397	+	Frame_Shift_Del	DEL	A	A	-			TCGA-TQ-A7RO-01A-11D-A33T-08	TCGA-TQ-A7RO-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cf5c481-732a-40a6-a557-2c2a837d7ed9	a291b686-5cc5-4e06-82fe-27e38cd997dc	g.chr20:25422397delA	ENST00000262460.4	+	6	601	c.507delA	c.(505-507)ttfs	p.L169fs	GINS1_ENST00000429262.2_3'UTR	NM_021067.3	NP_066545.3	Q14691	PSF1_HUMAN	GINS complex subunit 1 (Psf1 homolog)	169					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm		p.N172fs*14(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	7						CAGTCCTATTAAAAAAAAATA	0.299													8	172	---	---	---	---					
