Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6185286	6185287	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:6185286_6185287CC>AA	uc001amb.1	-	29	4367_4368	c.4267_4268GG>TT	c.(4267-4269)GGC>TTC	p.G1423F	CHD5_uc001alz.1_Missense_Mutation_p.G280F|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1423					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGCATTGAAGCCCAGCACCTGG	0.639			NA											4	5					0	0	0.004672	0	0
CHD5	26038	broad.mit.edu	37	1	6214773	6214773	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:6214773G>A	uc001amb.1	-	5	792	c.692C>T	c.(691-693)CCG>CTG	p.P231L		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	231					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGGCACCTGCGGGGGGCTGAC	0.542			NA											6	20					0	0	0.00308	0	0
LOC649330	649330	broad.mit.edu	37	1	12908066	12908066	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:12908066A>G	uc009vno.2	-	1	172	c.77T>C	c.(76-78)CTT>CCT	p.L26P	HNRNPCL1_uc010obf.1_Missense_Mutation_p.L26P	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	26							nucleic acid binding|nucleotide binding				0						CTTGACAACAAGAGTGTTGAG	0.448			NA											4	208					0	0	0.001984	0	0
PRAMEF18	391003	broad.mit.edu	37	1	13695833	13695833	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:13695833T>A	uc009vny.1	-	3	1179	c.1132A>T	c.(1132-1134)AAC>TAC	p.N378Y		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	378											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGTGAGGTTGGAGCAGCGG	0.552			NA											4	97					0	0	0.001168	0	0
PIGV	55650	broad.mit.edu	37	1	27117369	27117369	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:27117369G>T	uc001bmz.2	+	2	394	c.63G>T	c.(61-63)CTG>CTT	p.L21L	PIGV_uc001bmy.2_5'UTR|PIGV_uc009vso.2_Silent_p.L21L|PIGV_uc010ofg.1_5'UTR|PIGV_uc001bna.2_Silent_p.L21L	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	21	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		GCCGTATCCTGACTCTGATGC	0.547			NA											38	23					6.48837e-15	9.30617e-15	0.010771	1	0
RCC1	1104	broad.mit.edu	37	1	28864429	28864429	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:28864429G>T	uc001bqg.1	+	10	1261	c.1176G>T	c.(1174-1176)ATG>ATT	p.M392I	SNHG3-RCC1_uc001bqa.1_Missense_Mutation_p.M392I|SNHG3-RCC1_uc001bqb.1_Missense_Mutation_p.M392I|SNHG3-RCC1_uc001bqc.1_Missense_Mutation_p.M392I|RCC1_uc001bqe.1_Missense_Mutation_p.M409I|RCC1_uc001bqf.1_Missense_Mutation_p.M423I	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	392	RCC1 7.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TGGAGATGATGGGCAAACAGC	0.557			NA											11	10					1.58986e-06	1.86475e-06	0.008291	1	0
CSMD2	114784	broad.mit.edu	37	1	34112407	34112407	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:34112407G>A	uc001bxn.1	-	29	4524	c.4495C>T	c.(4495-4497)CTC>TTC	p.L1499F	CSMD2_uc001bxm.1_Missense_Mutation_p.L1539F|CSMD2_uc001bxo.1_Missense_Mutation_p.L412F	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1499	CUB 9.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TAGATATGGAGGAAGTCATAG	0.542			NA											8	8					0	0	0.004482	0	0
CSMD2	114784	broad.mit.edu	37	1	34112410	34112410	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:34112410A>C	uc001bxn.1	-	29	4521	c.4492T>G	c.(4492-4494)TTC>GTC	p.F1498V	CSMD2_uc001bxm.1_Missense_Mutation_p.F1538V|CSMD2_uc001bxo.1_Missense_Mutation_p.F411V	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1498	CUB 9.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATATGGAGGAAGTCATAGCCA	0.547			NA											8	8					0	0	0.004482	0	0
CTPS	1503	broad.mit.edu	37	1	41461722	41461722	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:41461722G>T	uc001cgk.3	+	8	1362	c.854G>T	c.(853-855)TGG>TTG	p.W285L	CTPS_uc010ojo.1_Missense_Mutation_p.W54L|CTPS_uc010ojp.1_Missense_Mutation_p.W292L|CTPS_uc001cgl.3_Missense_Mutation_p.W285L|CTPS_uc010ojq.1_Missense_Mutation_p.W129L|CTPS_uc009vwe.2_Missense_Mutation_p.W5L	NM_001905	NP_001896	P17812	PYRG1_HUMAN	CTP synthase	285					CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)	CTGATGAAATGGAAAGAGATG	0.488			NA											9	37					2.17888e-05	2.48967e-05	0.006214	1	0
HIVEP3	59269	broad.mit.edu	37	1	42047134	42047134	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:42047134C>G	uc001cgz.3	-	4	4548	c.3335G>C	c.(3334-3336)GGG>GCG	p.G1112A	HIVEP3_uc001cha.3_Missense_Mutation_p.G1112A|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1112					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CACAGTGGGCCCCAATGGGGG	0.632			NA											15	77					0	0	0.00245	0	0
IL12RB2	3595	broad.mit.edu	37	1	67804386	67804386	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:67804386G>A	uc001ddu.2	+	8	1678	c.1038G>A	c.(1036-1038)AAG>AAA	p.K346K	IL12RB2_uc010oqi.1_Silent_p.K346K|IL12RB2_uc010oqj.1_Silent_p.K346K|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Silent_p.K346K|IL12RB2_uc010oqm.1_Silent_p.K346K|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	346	Fibronectin type-III 3.|Extracellular (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						TTTTCTGGAAGGTGAGTTTTA	0.368			NA											18	53					0	0	0.007413	0	0
C1orf173	127254	broad.mit.edu	37	1	75037360	75037360	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:75037360C>A	uc001dgg.2	-	14	4253	c.4034G>T	c.(4033-4035)GGA>GTA	p.G1345V		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1345	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTCACCACCTCCGTGTAGAAC	0.537			NA											19	72					2.39556e-15	3.50264e-15	0.00278	1	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77094408	77094408	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:77094408T>G	uc001dhh.2	+	5	998	c.835T>G	c.(835-837)TTT>GTT	p.F279V	ST6GALNAC3_uc010orh.1_Missense_Mutation_p.F178V	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	279	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						GGGTCATAGGTTTATCACTGA	0.378			NA											30	65					0	0	0.00632	0	0
PTGFR	5737	broad.mit.edu	37	1	79002220	79002220	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:79002220G>T	uc001din.2	+	3	1194	c.928G>T	c.(928-930)GCT>TCT	p.A310S	PTGFR_uc001dim.2_3'UTR	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	310	Cytoplasmic (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	TCTACGAAAGGCTGTCCTTAA	0.378			NA											14	86					1.5739e-10	2.09389e-10	0.004007	1	0
WDR63	126820	broad.mit.edu	37	1	85547062	85547062	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:85547062A>T	uc001dkt.2	+	4	440	c.249A>T	c.(247-249)GCA>GCT	p.A83A	WDR63_uc009wcl.2_Silent_p.A83A	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	83										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		ACAGAGCTGCAGTATCTGATT	0.363			NA											26	74					0	0	0.007291	0	0
COL24A1	255631	broad.mit.edu	37	1	86210400	86210400	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:86210400G>T	uc001dlj.2	-	57	4663	c.4621C>A	c.(4621-4623)CCA>ACA	p.P1541T	COL24A1_uc001dli.2_Missense_Mutation_p.P656T|COL24A1_uc010osd.1_Missense_Mutation_p.P841T|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1541	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATTCGTGCTGGGTTATCTCGT	0.368			NA											25	30					4.7796e-09	6.02855e-09	0.004656	1	0
STXBP3	6814	broad.mit.edu	37	1	109315285	109315285	+	Splice_Site	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:109315285A>T	uc001dvy.2	+	7	514	c.439_splice	c.e7-2	p.V147_splice	STXBP3_uc001dvz.2_Splice_Site	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3						negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding	p.?(1)		ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		GTCTTAACTTAGGTGTATACT	0.279			NA											9	27					0	0	0.004482	0	0
CASQ2	845	broad.mit.edu	37	1	116287460	116287460	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:116287460G>T	uc001efx.3	-	2	572	c.308C>A	c.(307-309)GCC>GAC	p.A103D	CASQ2_uc010owu.1_Missense_Mutation_p.A103D	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	103					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CAGTTTCTTGGCAAGCTTGGC	0.403			NA											20	25					1.55795e-14	2.22184e-14	0.012319	1	0
TTF2	8458	broad.mit.edu	37	1	117605061	117605061	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:117605061G>T	uc001egy.2	+	3	204	c.184G>T	c.(184-186)GGT>TGT	p.G62C	TTF2_uc001egx.1_Missense_Mutation_p.G62C	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	62					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		AGAGCTTCAGGGTTTGCTTCT	0.378			NA											5	68					3.59834e-05	4.09916e-05	0.001168	1	0
SPAG17	200162	broad.mit.edu	37	1	118550797	118550797	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:118550797C>T	uc001ehk.2	-	31	4525	c.4457G>A	c.(4456-4458)AGG>AAG	p.R1486K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1486						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTTCACCTGCCTGGTGACAGT	0.498			NA											10	26					0	0	0.008291	0	0
HSD3B2	3284	broad.mit.edu	37	1	119985605	119985605	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:119985605T>A	uc001ehu.2	+	4	554	c.412T>A	c.(412-414)TGT>AGT	p.C138S				P26439	3BHS2_HUMAN	RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; AltName: Full=3-beta-HSD II; Includes:   RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase;            EC=1.1.1.145;   AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase;   AltName: Full=Progesterone reductase; Includes:   RecName: Full=Steroid Delta-isomerase;            EC=5.3.3.1;   AltName: Full=Delta-5-3-ketosteroid isomerase;	Error:Variant_position_missing_in_P26439_after_alignment					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CCACACCGCCTGTATCATTGA	0.507			NA											6	41					0	0	0.001168	0	0
HSD3B2	3284	broad.mit.edu	37	1	119985679	119985679	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:119985679G>T	uc001ehu.2	+	4	628	c.486G>T	c.(484-486)TGG>TGT	p.W162C				P26439	3BHS2_HUMAN	RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; AltName: Full=3-beta-HSD II; Includes:   RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase;            EC=1.1.1.145;   AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase;   AltName: Full=Progesterone reductase; Includes:   RecName: Full=Steroid Delta-isomerase;            EC=5.3.3.1;   AltName: Full=Delta-5-3-ketosteroid isomerase;	Error:Variant_position_missing_in_P26439_after_alignment					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GGGTAGCCTGGGGAGGAGATA	0.493			NA											9	13					3.09899e-07	3.72175e-07	0.004482	1	0
HMGCS2	3158	broad.mit.edu	37	1	120301895	120301895	+	Silent	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:120301895T>A	uc001eid.2	-	4	747	c.696A>T	c.(694-696)GGA>GGT	p.G232G	HMGCS2_uc010oxj.1_Silent_p.G190G|HMGCS2_uc001eie.2_Silent_p.G140G	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	232					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		CCATATGGGTTCCCCTCAGCC	0.473			NA											33	21					0	0	0.004878	0	0
CRNN	49860	broad.mit.edu	37	1	152384671	152384671	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:152384671C>G	uc001ezx.2	-	2	113	c.39G>C	c.(37-39)GAG>GAC	p.E13D		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	13					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGAAGGCCTCGATGATCC	0.502			NA											5	143					0	0	0.000602	0	0
FAM189B	10712	broad.mit.edu	37	1	155220391	155220391	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:155220391G>A	uc001fjm.2	-	9	1792	c.1186C>T	c.(1186-1188)CCA>TCA	p.P396S	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_Missense_Mutation_p.P198S|FAM189B_uc001fjn.2_Missense_Mutation_p.P300S|FAM189B_uc001fjo.2_Missense_Mutation_p.P378S|FAM189B_uc001fjp.2_Intron	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	396						integral to membrane	WW domain binding			ovary(1)|breast(1)	2						GCAGCCCGTGGGGGGCGCCGT	0.716			NA											8	15					0	0	0.008291	0	0
BCAN	63827	broad.mit.edu	37	1	156622549	156622549	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:156622549G>T	uc001fpp.2	+	8	2143	c.1807G>T	c.(1807-1809)GGT>TGT	p.G603C	BCAN_uc001fpo.2_Missense_Mutation_p.G603C	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	603					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCCCCTGAGGGTACCAGGGA	0.647			NA											7	32					3.09899e-07	3.72175e-07	0.004482	1	0
CD1B	910	broad.mit.edu	37	1	158299405	158299405	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:158299405C>T	uc001frx.2	-	4	749	c.641G>A	c.(640-642)AGT>AAT	p.S214N	CD1B_uc001frw.2_Missense_Mutation_p.S107N	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	214	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					AGGTCCAGGACTGGGGCCACT	0.547			NA											4	97					0	0	0.009096	0	0
SPTA1	6708	broad.mit.edu	37	1	158607998	158607998	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:158607998C>G	uc001fst.1	-	36	5213	c.5014G>C	c.(5014-5016)GAT>CAT	p.D1672H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1672	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GAGAGCAAATCTTCAGCCAAT	0.418			NA											21	69					0	0	0.00333	0	0
SPTA1	6708	broad.mit.edu	37	1	158644338	158644339	+	Nonsense_Mutation	DNP	GC	GC	AA			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:158644338_158644339GC>AA	uc001fst.1	-	9	1438_1439	c.1239_1240GC>TT	c.(1237-1242)CAGCAG>CATTAG	p.413_414QQ>H*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	413_414	Spectrin 5.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACCTTATGCTGCTGATGCCTGT	0.51			NA											9	212					0	0	0.004672	0	0
OR6N1	128372	broad.mit.edu	37	1	158736290	158736290	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:158736290G>T	uc010piq.1	-	1	183	c.183C>A	c.(181-183)CAC>CAA	p.H61Q		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGCTGACAAAGTGGTACATGG	0.483			NA											24	63					4.87955e-14	6.93265e-14	0.005443	1	0
APCS	325	broad.mit.edu	37	1	159558097	159558097	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:159558097A>T	uc001ftv.2	+	2	367	c.271A>T	c.(271-273)AGT>TGT	p.S91C		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	91	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					TGGAGAGTATAGTCTATACAT	0.443			NA											77	73					0	0	0.00361	0	0
VANGL2	57216	broad.mit.edu	37	1	160390211	160390211	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:160390211G>T	uc001fwb.1	+	6	1110	c.811G>T	c.(811-813)GTG>TTG	p.V271L	VANGL2_uc001fwc.1_Missense_Mutation_p.V271L	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	271	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATCCAGCGCGTGGCAGTGTG	0.607			NA											33	63					5.04308e-16	7.51968e-16	0.00623	1	0
SLAMF7	57823	broad.mit.edu	37	1	160709145	160709145	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:160709145A>T	uc001fwq.2	+	1	69	c.54A>T	c.(52-54)ACA>ACT	p.T18T	SLAMF7_uc010pjn.1_Silent_p.T18T|SLAMF7_uc001fws.2_Silent_p.T18T|SLAMF7_uc001fwr.2_Silent_p.T18T|SLAMF7_uc010pjo.1_Silent_p.T18T|SLAMF7_uc010pjp.1_Silent_p.T18T|SLAMF7_uc010pjq.1_Silent_p.T18T|SLAMF7_uc010pjr.1_Silent_p.T18T	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	18					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GGCAGCTCACAGGTGAGTCCG	0.532			NA											48	65					0	0	0.00361	0	0
OLFML2B	25903	broad.mit.edu	37	1	161953809	161953809	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:161953809C>A	uc001gbu.2	-	8	2333	c.1909G>T	c.(1909-1911)GAC>TAC	p.D637Y	OLFML2B_uc001gbt.2_Missense_Mutation_p.D120Y|OLFML2B_uc010pkq.1_Missense_Mutation_p.D638Y	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	637	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CCCTCATCGTCCAGGGCCGGG	0.637			NA											9	36					3.86212e-05	4.37978e-05	0.008291	1	0
UCK2	7371	broad.mit.edu	37	1	165876981	165876982	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:165876981_165876982GG>TT	uc001gdp.2	+	7	888_889	c.707_708GG>TT	c.(706-708)CGG>CTT	p.R236L	UCK2_uc010plb.1_Missense_Mutation_p.R98L	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	236					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					CCCTCCAAACGGCAGACCAATG	0.619			NA											36	54					0	0	0.004672	0	0
TNR	7143	broad.mit.edu	37	1	175375584	175375584	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:175375584C>T	uc001gkp.1	-	1	348	c.267G>A	c.(265-267)CAG>CAA	p.Q89Q	TNR_uc009wwu.1_Silent_p.Q89Q|TNR_uc010pmz.1_Silent_p.Q89Q	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	89					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CACTCACCTCCTGCTCAGCAG	0.547			NA											46	46					0	0	0.011902	0	0
ASTN1	460	broad.mit.edu	37	1	176903321	176903321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:176903321G>A	uc001glc.2	-	16	2850	c.2638C>T	c.(2638-2640)CGA>TGA	p.R880*	ASTN1_uc001glb.1_Nonsense_Mutation_p.R880*|ASTN1_uc001gld.1_Nonsense_Mutation_p.R880*	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	888					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						AGCCAGAGTCGCCGCTGGACC	0.502			NA											5	74					0	0	0.001168	0	0
CACNA1E	777	broad.mit.edu	37	1	181727186	181727186	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:181727186C>T	uc001gow.2	+	31	4598	c.4433C>T	c.(4432-4434)CCG>CTG	p.P1478L	CACNA1E_uc009wxs.2_Missense_Mutation_p.P1366L|CACNA1E_uc001gox.1_Missense_Mutation_p.P704L|CACNA1E_uc009wxt.2_Missense_Mutation_p.P704L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1478	IV.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GTGGTGTCTCCGTCCTTTGAG	0.557			NA											17	60					0	0	0.00499	0	0
PTGS2	5743	broad.mit.edu	37	1	186643683	186643683	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:186643683T>G	uc001gsb.2	-	10	1754	c.1617A>C	c.(1615-1617)GAA>GAC	p.E539D	PTGS2_uc009wyo.2_Missense_Mutation_p.E386D	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	539					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GAAAACCCACTTCTCCACCAA	0.443			NA											66	82					0	0	0.00361	0	0
FAM5C	339479	broad.mit.edu	37	1	190067374	190067374	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:190067374G>T	uc001gse.1	-	8	2307	c.2075C>A	c.(2074-2076)ACT>AAT	p.T692N	FAM5C_uc010pot.1_Missense_Mutation_p.T590N	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	692						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GGATCCCTGAGTATAGGGGTA	0.453			NA											28	93					7.01153e-11	9.4112e-11	0.007291	1	0
ZBTB41	360023	broad.mit.edu	37	1	197169211	197169211	+	Silent	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:197169211T>A	uc001gtx.1	-	1	462	c.393A>T	c.(391-393)GTA>GTT	p.V131V	ZBTB41_uc009wyz.1_RNA|CRB1_uc010poz.1_5'Flank	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	131	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CTGAATGTGTTACGTGATCCA	0.353			NA											23	41					0	0	0.004656	0	0
KIF14	9928	broad.mit.edu	37	1	200587437	200587437	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:200587437C>A	uc010ppk.1	-	2	854	c.415G>T	c.(415-417)GAT>TAT	p.D139Y	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	139	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTGACAGAATCTATTTCAGCT	0.348			NA											38	68					1.60099e-16	2.40627e-16	0.004878	1	0
CACNA1S	779	broad.mit.edu	37	1	201061212	201061212	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:201061212G>C	uc001gvv.2	-	4	656	c.429C>G	c.(427-429)AAC>AAG	p.N143K		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	143	Extracellular (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTTGGATGACGTTAACCTGTT	0.592			NA											31	82					0	0	0.012213	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209935992	209935992	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:209935992C>A	uc001hho.2	+	4	768	c.478C>A	c.(478-480)CCC>ACC	p.P160T	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.P140T|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.P160T|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.P140T|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.P160T	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	160	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CAAGAAGCCACCCAAACACCA	0.597			NA											18	21					8.34094e-07	9.85985e-07	0.008871	1	0
KCNH1	3756	broad.mit.edu	37	1	211192199	211192199	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:211192199C>A	uc001hib.2	-	6	1128	c.958G>T	c.(958-960)GCC>TCC	p.A320S	KCNH1_uc001hic.2_Intron	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	320	Extracellular (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCCATAAAGGCACTAACCTCA	0.473			NA											46	91					8.86878e-18	1.3546e-17	0.00361	1	0
USH2A	7399	broad.mit.edu	37	1	216262470	216262470	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:216262470C>T	uc001hku.1	-	23	5157	c.4770G>A	c.(4768-4770)GTG>GTA	p.V1590V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1590	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGTTACTTCCACTGGTGACC	0.328			NA								HNSCC(13;0.011)			21	83					0	0	0.002299	0	0
USH2A	7399	broad.mit.edu	37	1	216465702	216465702	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:216465702C>A	uc001hku.1	-	10	2042	c.1655G>T	c.(1654-1656)TGC>TTC	p.C552F	USH2A_uc001hkv.2_Missense_Mutation_p.C552F	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	552	Laminin EGF-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGAGGCAAGCAGCGATCACA	0.363			NA								HNSCC(13;0.011)			13	40					0.000151284	0.000169017	0.001855	1	0
C1orf69	200205	broad.mit.edu	37	1	228362629	228362629	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:228362629G>C	uc001hsl.3	+	2	667	c.578G>C	c.(577-579)CGC>CCC	p.R193P	C1orf69_uc010pvw.1_5'UTR	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	193					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CGAACAGCACGCATGGGGTGG	0.692			NA											8	21					0	0	0.004482	0	0
ZP4	57829	broad.mit.edu	37	1	238053432	238053432	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:238053432C>A	uc001hym.2	-	2	220	c.220G>T	c.(220-222)GGC>TGC	p.G74C	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	74	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATCCAGGTGCCACAGTCGGAG	0.562	NSCLC(166;160 2029 11600 18754 19936)		NA											17	65					5.35267e-07	6.39771e-07	0.007413	1	0
OR2W3	343171	broad.mit.edu	37	1	248059435	248059435	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:248059435G>T	uc001idp.1	+	3	816	c.547G>T	c.(547-549)GCC>TCC	p.A183S	OR2W3_uc010pzb.1_Missense_Mutation_p.A183S	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGAGATGCCCGCCCTGATCCG	0.637			NA											13	39					2.41591e-17	3.66687e-17	0.004656	1	0
OR2AK2	391191	broad.mit.edu	37	1	248128993	248128993	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:248128993G>T	uc010pzd.1	+	1	360	c.360G>T	c.(358-360)TTG>TTT	p.L120F	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ATGTGTTCTTGGCCCTTGGTG	0.443	Melanoma(45;390 1181 23848 28461 41504)		NA											59	203					2.53126e-37	4.68314e-37	0.00361	1	0
OR2AK2	391191	broad.mit.edu	37	1	248129570	248129570	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:248129570A>T	uc010pzd.1	+	1	937	c.937A>T	c.(937-939)ACG>TCG	p.T313S	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TAAGGAAGTGACGGGGGCAGT	0.433	Melanoma(45;390 1181 23848 28461 41504)		NA											32	38					0	0	0.010818	0	0
OR2L2	26246	broad.mit.edu	37	1	248202292	248202292	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:248202292C>G	uc001idw.2	+	1	819	c.723C>G	c.(721-723)AGC>AGG	p.S241R	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAACCTGTAGCACCCACCTCA	0.502			NA											41	59					0	0	0.010771	0	0
TAF3	83860	broad.mit.edu	37	10	7866336	7866336	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:7866336G>T	uc010qbd.1	+	2	222	c.222G>T	c.(220-222)GGG>GGT	p.G74G		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	74					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						AGCTGATGGGGGTTAGTCTAC	0.403			NA											62	154					5.86059e-21	9.49037e-21	0.00361	1	0
OLAH	55301	broad.mit.edu	37	10	15103797	15103797	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:15103797G>C	uc001inu.2	+	4	492	c.238G>C	c.(238-240)GAT>CAT	p.D80H	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Missense_Mutation_p.D133H	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	80					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						CCAGTTAGTTGATGAAGTTGT	0.423			NA											76	150					0	0	0.00361	0	0
STAM	8027	broad.mit.edu	37	10	17737165	17737166	+	Missense_Mutation	DNP	TA	TA	AT			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:17737165_17737166TA>AT	uc001ipj.1	+	7	869_870	c.653_654TA>AT	c.(652-654)ATA>AAT	p.I218N	STAM_uc010qcf.1_Missense_Mutation_p.I107N|STAM_uc009xjw.1_5'UTR	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	218	SH3.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						GTTCGTGCTATATATGACTTTG	0.366			NA											44	67					0	0	0.004672	0	0
NEBL	10529	broad.mit.edu	37	10	21158739	21158739	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:21158739T>A	uc001iqi.2	-	6	909	c.512A>T	c.(511-513)CAC>CTC	p.H171L	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	171	Nebulin 4.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						ACTGTACGTGTGGGTGTCCTG	0.378			NA											31	95					0	0	0.002836	0	0
C10orf140	387640	broad.mit.edu	37	10	21805106	21805106	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:21805106C>A	uc009xkd.2	-	4	3899	c.1646G>T	c.(1645-1647)AGG>ATG	p.R549M	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	468						nucleus	nucleotide binding			ovary(1)	1						CTCAGATACCCTATCGTTCCT	0.542			NA											26	71					3.73988e-18	5.72385e-18	0.00632	1	0
SVIL	6840	broad.mit.edu	37	10	29813491	29813491	+	Silent	SNP	C	C	A	rs113842540	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:29813491C>A	uc001iut.1	-	14	3249	c.2496G>T	c.(2494-2496)GCG>GCT	p.A832A	SVIL_uc010qdw.1_5'Flank|SVIL_uc001iuu.1_Silent_p.A406A	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	832					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				GGGTAGAAATCGCTTTTGAGA	0.507			NA											48	80					4.01344e-20	6.43004e-20	0.00361	1	0
ZNF438	220929	broad.mit.edu	37	10	31138643	31138643	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:31138643G>T	uc010qdz.1	-	7	1126	c.691C>A	c.(691-693)CAG>AAG	p.Q231K	ZNF438_uc001ivn.2_Missense_Mutation_p.Q182K|ZNF438_uc010qdy.1_Missense_Mutation_p.Q221K|ZNF438_uc001ivo.3_Intron|ZNF438_uc009xlg.2_Missense_Mutation_p.Q231K|ZNF438_uc001ivp.3_Missense_Mutation_p.Q221K|ZNF438_uc010qea.1_Missense_Mutation_p.Q231K|ZNF438_uc010qeb.1_Missense_Mutation_p.Q231K|ZNF438_uc010qec.1_Intron	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GTGAGGTCCTGCTTGGCAGGC	0.488			NA											61	115					1.12612e-26	1.9272e-26	0.00361	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	A	G	rs2257765		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453			NA											5	60					0	0	0.000602	0	0
OGDHL	55753	broad.mit.edu	37	10	50958893	50958893	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:50958893C>G	uc001jie.2	-	7	1030	c.888G>C	c.(886-888)ATG>ATC	p.M296I	OGDHL_uc009xog.2_Missense_Mutation_p.M323I|OGDHL_uc010qgt.1_Missense_Mutation_p.M239I|OGDHL_uc010qgu.1_Missense_Mutation_p.M87I|OGDHL_uc009xoh.2_Missense_Mutation_p.M87I	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	296					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						ACCTGTGTGGCATCCCCAAGA	0.572			NA											3	19					0	0	0.009096	0	0
CSTF2T	23283	broad.mit.edu	37	10	53458690	53458690	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:53458690G>A	uc001jjp.2	-	1	666	c.620C>T	c.(619-621)TCT>TTT	p.S207F	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	207					mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GACAGACACAGACTGAGATTT	0.428			NA											19	23					0	0	0.006122	0	0
HERC4	26091	broad.mit.edu	37	10	69700696	69700696	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:69700696C>A	uc001jng.3	-	21	2839	c.2528G>T	c.(2527-2529)AGA>ATA	p.R843I	HERC4_uc009xpq.2_Missense_Mutation_p.S376I|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.R835I|HERC4_uc009xpr.2_Intron|HERC4_uc001jni.3_Missense_Mutation_p.R579I	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	843	HECT.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						TCCAACTAACCTCCCAACATC	0.358			NA											40	81					2.45108e-15	3.57686e-15	0.00874	1	0
C10orf27	219793	broad.mit.edu	37	10	72539382	72539382	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:72539382G>A	uc001jrj.1	-	5	784	c.394C>T	c.(394-396)CCA>TCA	p.P132S	C10orf27_uc010qjm.1_Missense_Mutation_p.P132S|C10orf27_uc009xqh.1_RNA|C10orf27_uc010qjn.1_Missense_Mutation_p.P132S|C10orf27_uc009xqi.1_Intron|C10orf27_uc010qjo.1_Missense_Mutation_p.P121S|C10orf27_uc009xqj.1_Silent_p.T126T|C10orf27_uc010qjp.1_Missense_Mutation_p.P121S	NM_152710	NP_689923	Q96M53	SPATL_HUMAN	stromal protein associated with thymii and lymph	132					cell differentiation|multicellular organismal development|spermatogenesis	cytosol				skin(1)	1						TTAGACTGTGGGTCTCCAATG	0.572			NA											7	44					0	0	0.001984	0	0
BTAF1	9044	broad.mit.edu	37	10	93776187	93776187	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:93776187A>T	uc001khr.2	+	33	4773	c.4675A>T	c.(4675-4677)AAA>TAA	p.K1559*		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1559					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				AGAAACTGAAAAACCAAAGCT	0.294			NA											13	49					0	0	0.001855	0	0
PLCE1	51196	broad.mit.edu	37	10	96018635	96018635	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:96018635C>A	uc001kjk.2	+	12	4267	c.3633C>A	c.(3631-3633)AGC>AGA	p.S1211R	PLCE1_uc010qnx.1_Missense_Mutation_p.S1195R|PLCE1_uc001kjm.2_Missense_Mutation_p.S903R	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1211					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TTTCAGATAGCAACATGAGTT	0.443			NA											14	56					0.000219431	0.000243346	0.00245	1	0
NOLC1	9221	broad.mit.edu	37	10	103919024	103919024	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:103919024G>T	uc001kuo.2	+	6	917	c.682G>T	c.(682-684)GAT>TAT	p.D228Y	NOLC1_uc001kup.2_Missense_Mutation_p.D228Y|NOLC1_uc001kuq.2_Missense_Mutation_p.D229Y|NOLC1_uc009xxb.1_5'UTR|NOLC1_uc001kur.2_5'UTR	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	228	11 X 12 AA approximate repeats of an acidic serine cluster.|Acidic serine cluster 4.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		cagtagcagTGATGACTCAGA	0.398			NA											44	59					7.53189e-24	1.26314e-23	0.007835	1	0
NFKB2	4791	broad.mit.edu	37	10	104157797	104157797	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:104157797C>T	uc001kvb.2	+	9	986	c.721C>T	c.(721-723)CGG>TGG	p.R241W	NFKB2_uc001kva.2_Missense_Mutation_p.R241W|NFKB2_uc010qqk.1_Missense_Mutation_p.R241W|NFKB2_uc001kvd.2_Missense_Mutation_p.R241W|NFKB2_uc009xxc.2_Missense_Mutation_p.R241W	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	241	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		AGGCTCTGTGCGGGGTGGAGA	0.498			NA	T	IGH@	B-NHL								9	133					0	0	0.008291	0	0
SORCS3	22986	broad.mit.edu	37	10	106907476	106907476	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:106907476G>A	uc001kyi.1	+	9	1631	c.1404G>A	c.(1402-1404)GGG>GGA	p.G468G		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	468	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACACGCGTGGGATTTACTTCA	0.448	NSCLC(116;1497 1690 7108 13108 14106)		NA											14	59					0	0	0.004007	0	0
SORCS1	114815	broad.mit.edu	37	10	108923816	108923816	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:108923816C>G	uc001kym.2	-	1	477	c.469G>C	c.(469-471)GAG>CAG	p.E157Q	SORCS1_uc001kyl.2_Missense_Mutation_p.E157Q|SORCS1_uc009xxs.2_Missense_Mutation_p.E157Q|SORCS1_uc001kyn.1_Missense_Mutation_p.E157Q|SORCS1_uc001kyo.2_Missense_Mutation_p.E157Q	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	157	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGTCTCAGCTCCTCCATCCGG	0.637			NA											12	39					0	0	0.010729	0	0
SLC18A2	6571	broad.mit.edu	37	10	119017345	119017345	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:119017345G>T	uc001ldd.1	+	10	964	c.933G>T	c.(931-933)CTG>CTT	p.L311L	SLC18A2_uc009xyy.1_Silent_p.L108L	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	311	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TCGCCATGCTGGAGCCAGCCC	0.542			NA											13	20					0.00010058	0.000112536	0.001368	1	0
PDZD8	118987	broad.mit.edu	37	10	119044378	119044378	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:119044378C>A	uc001lde.1	-	5	2065	c.1866G>T	c.(1864-1866)GTG>GTT	p.V622V		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	622	Pro-rich.				intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		GAGGTGGCACCACCTTCTCTG	0.483			NA											23	81					1.96895e-08	2.44253e-08	0.00278	1	0
HMX2	3167	broad.mit.edu	37	10	124909093	124909093	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:124909093C>A	uc001lhc.1	+	2	533	c.276C>A	c.(274-276)CCC>CCA	p.P92P		NM_005519	NP_005510	A2RU54	HMX2_HUMAN	H6 family homeobox 2	92					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.169)|Colorectal(57;0.207)|Glioma(114;0.222)		Colorectal(40;0.123)|COAD - Colon adenocarcinoma(40;0.141)		CAGGTACCCCCAAGGGCAGCG	0.642			NA											15	46					6.94344e-10	9.0145e-10	0.006122	1	0
DPYSL4	10570	broad.mit.edu	37	10	134006275	134006275	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:134006275T>A	uc009ybb.2	+	3	396	c.242T>A	c.(241-243)CTG>CAG	p.L81Q		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	81					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		ATGCCTGTCCTGGGCATGACA	0.602			NA											17	48					0	0	0.008871	0	0
KNDC1	85442	broad.mit.edu	37	10	134999589	134999589	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:134999589C>T	uc001llz.1	+	6	738	c.737C>T	c.(736-738)CCG>CTG	p.P246L	KNDC1_uc001lma.1_Missense_Mutation_p.P181L	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	246					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCCGAAGGCCCGGAGTCTGAG	0.721			NA											3	10					0	0	0.004672	0	0
FRG2B	441581	broad.mit.edu	37	10	135438789	135438789	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:135438789C>T	uc010qvg.1	-	4	704	c.651G>A	c.(649-651)CTG>CTA	p.L217L		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	217						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CCTGGGCACACAGAGGCCCCC	0.597			NA											5	35					0	0	0.008291	0	0
MUC2	4583	broad.mit.edu	37	11	1104231	1104231	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:1104231C>T	uc001lsx.1	+	52	15535	c.15508C>T	c.(15508-15510)CGG>TGG	p.R5170W		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	5170						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCGCCGGGCCCGGCGCTCCCC	0.706			NA											3	12					0	0	0.009096	0	0
MUC5B	727897	broad.mit.edu	37	11	1269245	1269245	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:1269245C>A	uc009ycr.1	+	50	12845	c.12719C>A	c.(12718-12720)CCG>CAG	p.P4240Q	MUC5B_uc001ltb.2_Missense_Mutation_p.P3715Q	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3712	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACGGCCACCCCGTCCTCCACC	0.657			NA											34	67					4.64027e-19	7.29461e-19	0.00361	1	0
OR52K2	119774	broad.mit.edu	37	11	4471398	4471398	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:4471398C>A	uc001lyz.1	+	1	829	c.829C>A	c.(829-831)CTC>ATC	p.L277I		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTCCACATCCTCCTTGCCAA	0.498			NA											68	83					5.41795e-27	9.33574e-27	0.00361	1	0
OR51F2	119694	broad.mit.edu	37	11	4843368	4843368	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:4843368C>A	uc010qyn.1	+	1	753	c.753C>A	c.(751-753)GCC>GCA	p.A251A		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	251	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCGGAAAGCCTTCAACACCT	0.502			NA											20	49					9.7654e-05	0.000109916	0.007413	1	0
OR52A4	390053	broad.mit.edu	37	11	5142424	5142424	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:5142424C>A	uc001lzz.1	-	1	385	c.385G>T	c.(385-387)GCG>TCG	p.A129S	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TAACAGATCGCTACACAGCGG	0.468			NA											9	25					0.00448238	0.00476055	0.004482	1	0
OR52A5	390054	broad.mit.edu	37	11	5153746	5153746	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:5153746C>T	uc010qyx.1	-	1	127	c.127G>A	c.(127-129)GGA>AGA	p.G43R		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G43E(1)		skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGGGAATTTCCAATCACACCA	0.403			NA											26	42					0	0	0.00333	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444219	5444219	+	Silent	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:5444219T>A	uc010qzd.1	+	1	789	c.789T>A	c.(787-789)ACT>ACA	p.T263T	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATCTATGACTCATCGCTTTG	0.527			NA											55	52					0	0	0.00361	0	0
OR56A1	120796	broad.mit.edu	37	11	6048764	6048764	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:6048764C>A	uc010qzw.1	-	1	171	c.171G>T	c.(169-171)CAG>CAT	p.Q57H		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	57	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGCCTCCAGCTGGATGGTGA	0.622			NA											28	22					3.80469e-20	6.1086e-20	0.009535	1	0
ZNF214	7761	broad.mit.edu	37	11	7022736	7022736	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:7022736C>A	uc001mfa.2	-	3	481	c.178G>T	c.(178-180)GAA>TAA	p.E60*	ZNF214_uc010ray.1_Nonsense_Mutation_p.E60*|ZNF214_uc009yfh.1_Nonsense_Mutation_p.E60*	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	60	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TTTTCATATTCTAAGTATCTG	0.378	Ovarian(22;251 657 736 21522 46864)		NA											30	108					4.22769e-11	5.70511e-11	0.00632	1	0
RBMXL2	27288	broad.mit.edu	37	11	7111241	7111242	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:7111241_7111242GG>TT	uc001mfc.2	+	1	1077_1078	c.890_891GG>TT	c.(889-891)GGG>GTT	p.G297V		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	297	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCAGGACGGGGGACACCGCCAT	0.658			NA											12	9					0	0	0.004672	0	0
SYT9	143425	broad.mit.edu	37	11	7335047	7335047	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:7335047G>T	uc001mfe.2	+	3	1156	c.919G>T	c.(919-921)GTG>TTG	p.V307L	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	307	Cytoplasmic (Potential).|C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TCACTTCTCTGTGTACGACTT	0.468			NA											113	140					2.73796e-65	5.34116e-65	0.00361	1	0
OR5P2	120065	broad.mit.edu	37	11	7818288	7818288	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:7818288C>A	uc001mfp.1	-	1	202	c.202G>T	c.(202-204)GCC>TCC	p.A68S		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GATGAATAGGCCATGTCAGCA	0.438			NA											53	59					2.17126e-26	3.70738e-26	0.00361	1	0
INSC	387755	broad.mit.edu	37	11	15197461	15197461	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:15197461G>T	uc001mly.2	+	3	418	c.372G>T	c.(370-372)CTG>CTT	p.L124L	INSC_uc001mlz.2_Silent_p.L77L|INSC_uc001mma.2_Silent_p.L77L|INSC_uc010rcs.1_Silent_p.L77L|INSC_uc001mmb.2_Silent_p.L77L|INSC_uc001mmc.2_Silent_p.L77L	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	124					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TGCAGCTGCTGCTCAAACGGG	0.647			NA											13	13					3.27435e-08	4.01561e-08	0.00245	1	0
SLC6A5	9152	broad.mit.edu	37	11	20668432	20668432	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:20668432C>A	uc001mqd.2	+	14	2295	c.2022C>A	c.(2020-2022)AAC>AAA	p.N674K	SLC6A5_uc009yic.2_Missense_Mutation_p.N439K	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	674					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TCCAGCCTAACATCTTCTGGA	0.428			NA											31	38					2.47316e-13	3.47442e-13	0.003271	1	0
NELL1	4745	broad.mit.edu	37	11	20950015	20950015	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:20950015G>T	uc001mqe.2	+	9	1140	c.987G>T	c.(985-987)AAG>AAT	p.K329N	NELL1_uc001mqf.2_Missense_Mutation_p.K329N|NELL1_uc009yid.2_Missense_Mutation_p.K357N|NELL1_uc010rdo.1_Missense_Mutation_p.K272N|NELL1_uc010rdp.1_Missense_Mutation_p.K89N	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	329	VWFC 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						AGTGCTGTAAGGTCTGCCGAC	0.498			NA											27	34					2.4375e-19	3.85596e-19	0.007291	1	0
LUZP2	338645	broad.mit.edu	37	11	24927594	24927594	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:24927594G>T	uc001mqs.2	+	6	688	c.454G>T	c.(454-456)GAA>TAA	p.E152*	LUZP2_uc009yif.2_Nonsense_Mutation_p.E66*|LUZP2_uc009yig.2_Intron	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	152	Potential.					extracellular region				ovary(1)|skin(1)	2						CATTCACGCAGAAGAGGTGAG	0.338			NA											13	21					9.31168e-06	1.07212e-05	0.001855	1	0
RAG1	5896	broad.mit.edu	37	11	36597180	36597180	+	Silent	SNP	C	C	A	rs121918572		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:36597180C>A	uc001mwu.3	+	2	2450	c.2326C>A	c.(2326-2328)CGG>AGG	p.R776R	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	776					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GGAAGAACTGCGGGATCGGGT	0.483	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				16	60					2.23348e-06	2.60343e-06	0.004007	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136851	40136851	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:40136851T>C	uc001mxa.1	-	2	2956	c.992A>G	c.(991-993)AAC>AGC	p.N331S	LRRC4C_uc001mxc.1_Missense_Mutation_p.N327S|LRRC4C_uc001mxd.1_Missense_Mutation_p.N327S|LRRC4C_uc001mxb.1_Missense_Mutation_p.N327S	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	331	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGGAGGAGTGTTACACCGGGC	0.507			NA											17	19					0	0	0.004007	0	0
OR4C46	119749	broad.mit.edu	37	11	51515433	51515433	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:51515433C>A	uc010ric.1	+	1	152	c.152C>A	c.(151-153)CCA>CAA	p.P51Q		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	51	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACTGCCAGCCCATCACTGGGG	0.448			NA											86	107					1.55023e-36	2.84021e-36	0.00361	1	0
OR5B12	390191	broad.mit.edu	37	11	58206722	58206722	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:58206722C>A	uc010rkh.1	-	1	903	c.903G>T	c.(901-903)AAG>AAT	p.K301N		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCCCTACAGTCTTTTTAAAGG	0.338			NA											22	31					1.9806e-07	2.39389e-07	0.002299	1	0
CPSF7	79869	broad.mit.edu	37	11	61183865	61183865	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:61183865T>C	uc001nrq.2	-	6	811	c.677A>G	c.(676-678)AAT>AGT	p.N226S	CPSF7_uc001nro.2_Missense_Mutation_p.N217S|CPSF7_uc001nrp.2_Missense_Mutation_p.N269S|CPSF7_uc001nrr.2_Missense_Mutation_p.N217S|CPSF7_uc001nrs.1_Missense_Mutation_p.N127S	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	226	Pro-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						AGGAGGACGATTGAAGTAGGG	0.592			NA											46	68					0	0	0.00361	0	0
SLC22A12	116085	broad.mit.edu	37	11	64366303	64366303	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:64366303G>A	uc001oam.1	+	6	1725	c.978G>A	c.(976-978)GAG>GAA	p.E326E	SLC22A12_uc009ypr.1_Silent_p.E351E|SLC22A12_uc001oal.1_Silent_p.E105E|SLC22A12_uc009yps.1_Silent_p.E292E|SLC22A12_uc001oan.1_Silent_p.E218E|SLC22A12_uc009ypt.2_Silent_p.E144E	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	326			Missing (affects urate transport).		cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CCATGCGGGAGGAGCTGAGCA	0.662			NA											9	44					0	0	0.008291	0	0
NRXN2	9379	broad.mit.edu	37	11	64390268	64390268	+	Missense_Mutation	SNP	G	G	T	rs144512935		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:64390268G>T	uc001oap.2	-	6	1503	c.992C>A	c.(991-993)ACG>AAG	p.T331K	NRXN2_uc001oar.2_Missense_Mutation_p.T1377K|NRXN2_uc001oas.2_Missense_Mutation_p.T1307K|NRXN2_uc001oao.2_Missense_Mutation_p.T17K|NRXN2_uc001oaq.2_Missense_Mutation_p.T1044K	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	331	Poly-Thr.|Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GCCCCGGCGCgtggtggtagt	0.527			NA											7	29					0.000157383	0.000175051	0.00308	1	0
SPTBN2	6712	broad.mit.edu	37	11	66472300	66472300	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:66472300G>T	uc001ojd.2	-	14	2519	c.2447C>A	c.(2446-2448)ACA>AAA	p.T816K		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	816	Spectrin 5.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCGGCTCAGTGTGGGGGGCAG	0.716			NA											13	19					0.00010058	0.000112536	0.001368	1	0
DHCR7	1717	broad.mit.edu	37	11	71146589	71146589	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:71146589C>A	uc001oqk.2	-	9	1510	c.1260G>T	c.(1258-1260)CTG>CTT	p.L420L	DHCR7_uc001oql.2_Silent_p.L420L	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	420	Helical; (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	CGCCACAGGCCAGGCAGTAGG	0.672			NA							Smith-Lemli-Opitz_syndrome				10	21					0.000673444	0.000732808	0.008291	1	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293805	71293805	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:71293805C>A	uc001oqu.2	-	1	117	c.79G>T	c.(79-81)GGC>TGC	p.G27C		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	27						keratin filament					0						CCCCCACAGCCAGAGCCACAG	0.642			NA											33	43					2.46105e-21	4.0199e-21	0.010818	1	0
USP35	57558	broad.mit.edu	37	11	77916913	77916913	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:77916913G>A	uc009yva.1	+	7	1469	c.1223G>A	c.(1222-1224)CGC>CAC	p.R408H	USP35_uc001oze.2_Missense_Mutation_p.R164H|USP35_uc001ozc.2_5'UTR|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_Missense_Mutation_p.A18T|USP35_uc001ozf.2_Missense_Mutation_p.R139H	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	408					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			AATGAGGACCGCATCAAGCAG	0.582			NA											4	133					0	0	0.009096	0	0
RAB30	27314	broad.mit.edu	37	11	82698724	82698724	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:82698724T>C	uc001ozu.2	-	5	527	c.266A>G	c.(265-267)TAT>TGT	p.Y89C	RAB30_uc009yve.2_Missense_Mutation_p.Y87C|RAB30_uc010rst.1_Missense_Mutation_p.Y87C|RAB30_uc001ozv.2_Missense_Mutation_p.Y87C|RAB30_uc009yvg.1_Missense_Mutation_p.Y59C	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	89					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0						GGTAATGTCATAGGTGAGGAT	0.493			NA											34	47					0	0	0.012213	0	0
FAT3	120114	broad.mit.edu	37	11	92086050	92086050	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:92086050C>A	uc001pdj.3	+	1	789	c.772C>A	c.(772-774)CGC>AGC	p.R258S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	258	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCACATTGAGCGCATAAATGA	0.428			NA								TCGA Ovarian(4;0.039)			65	78					1.50372e-20	2.42463e-20	0.00361	1	0
ATM	472	broad.mit.edu	37	11	108183154	108183154	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:108183154G>T	uc001pkb.1	+	40	6320	c.5935G>T	c.(5935-5937)GAA>TAA	p.E1979*	ATM_uc009yxr.1_Nonsense_Mutation_p.E1979*|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Nonsense_Mutation_p.E631*|ATM_uc001pkg.1_Nonsense_Mutation_p.E336*|ATM_uc009yxt.1_Nonsense_Mutation_p.E93*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1979	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGCATTTGAAGAAGGAAGCCA	0.318			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			17	80					2.54575e-18	3.91214e-18	0.010504	1	0
ATM	472	broad.mit.edu	37	11	108205768	108205768	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:108205768G>A	uc001pkb.1	+	55	8468	c.8083G>A	c.(8083-8085)GGT>AGT	p.G2695S	ATM_uc009yxr.1_Missense_Mutation_p.G2695S|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.G1347S	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2695			G -> A (in T-prolymphocytic leukemia and B-cell chronic lymphocytic leukemia).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.G2695A(2)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CTTAGCAGGAGGTGTAAATTT	0.398			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			28	36					0	0	0.005443	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110461533	110461533	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:110461533C>G	uc001pkz.1	-	12	1429	c.1144G>C	c.(1144-1146)GAT>CAT	p.D382H	ARHGAP20_uc001pky.1_Missense_Mutation_p.D359H|ARHGAP20_uc009yyb.1_Missense_Mutation_p.D346H|ARHGAP20_uc001pla.1_Missense_Mutation_p.D346H|ARHGAP20_uc001plb.2_5'Flank	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	382	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		AAAAGCATATCCTATGGGGAA	0.423			NA											21	24					0	0	0.002299	0	0
TTC12	54970	broad.mit.edu	37	11	113235676	113235676	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:113235676G>C	uc001pnu.2	+	21	2041	c.1936G>C	c.(1936-1938)GAC>CAC	p.D646H	TTC12_uc001pnv.2_Missense_Mutation_p.D652H|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Missense_Mutation_p.D496H	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	646							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		GCTAAAGACGGACCTTTTGCA	0.577			NA											16	44					0	0	0.003163	0	0
TRIM29	23650	broad.mit.edu	37	11	119996462	119996462	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:119996462C>A	uc001pwz.2	-	4	1394	c.1270G>T	c.(1270-1272)GTT>TTT	p.V424F	TRIM29_uc001pwy.2_5'Flank|TRIM29_uc010rzi.1_Missense_Mutation_p.V163F|TRIM29_uc010rzj.1_Missense_Mutation_p.V157F|TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	424					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		ATCTTCTCAACGTGGCGCATG	0.592			NA											17	28					2.48551e-13	3.47878e-13	0.00499	1	0
ROBO4	54538	broad.mit.edu	37	11	124756669	124756669	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:124756669C>A	uc001qbg.2	-	16	2625	c.2485G>T	c.(2485-2487)GGG>TGG	p.G829W	ROBO4_uc010sas.1_Missense_Mutation_p.G684W|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Missense_Mutation_p.G387W	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	829					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CTGATGTACCCATAGGTGGTG	0.617			NA											13	52					4.7546e-09	6.00708e-09	0.004007	1	0
PKNOX2	63876	broad.mit.edu	37	11	125255501	125255501	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:125255501C>A	uc001qbu.2	+	6	596	c.282C>A	c.(280-282)ACC>ACA	p.T94T	PKNOX2_uc010saz.1_Silent_p.T65T|PKNOX2_uc010sba.1_Silent_p.T65T|PKNOX2_uc010sbb.1_Silent_p.T30T	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	94						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		AACAGGCCACCCAGGGCTCTG	0.557			NA											10	50					0.00136819	0.00146969	0.001368	1	0
ADIPOR2	79602	broad.mit.edu	37	12	1895226	1895226	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:1895226G>T	uc001qjm.2	+	8	1346	c.1149G>T	c.(1147-1149)GAG>GAT	p.E383D	ADIPOR2_uc001qjn.2_Missense_Mutation_p.E383D	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	383	Extracellular (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			GCAGTGAAGAGGATGCACTGT	0.537			NA											27	65					1.42536e-11	1.93386e-11	0.004656	1	0
CACNA2D4	93589	broad.mit.edu	37	12	2016649	2016649	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:2016649C>T	uc001qjp.2	-	6	969	c.738G>A	c.(736-738)TGG>TGA	p.W246*	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Nonsense_Mutation_p.W246*	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	246	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CAAAATATTGCCAGGTCAACG	0.458	Colon(2;101 179 21030 23310 28141)		NA											14	11					0	0	0.001855	0	0
FGF23	8074	broad.mit.edu	37	12	4479725	4479725	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:4479725G>T	uc001qmq.1	-	3	686	c.540C>A	c.(538-540)AGC>AGA	p.S180R		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	180		Cleavage; by proprotein convertases.			cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CGTCCTCGGCGCTCCGGGTGT	0.687			NA											11	30					4.93089e-13	6.87585e-13	0.00245	1	0
CHD4	1108	broad.mit.edu	37	12	6702648	6702648	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:6702648G>C	uc001qpo.2	-	16	2612	c.2448C>G	c.(2446-2448)ATC>ATG	p.I816M	CHD4_uc001qpn.2_Missense_Mutation_p.I809M|CHD4_uc001qpp.2_Missense_Mutation_p.I813M	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	816	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CATTCTCTCGGATGATGGCAC	0.517	Colon(32;586 792 4568 16848 45314)		NA											43	70					0	0	0.009718	0	0
KLRF1	51348	broad.mit.edu	37	12	9997030	9997030	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:9997030G>T	uc010sgw.1	+	7	665	c.601G>T	c.(601-603)GGA>TGA	p.G201*	KLRF1_uc009zgw.2_Nonsense_Mutation_p.G152*|KLRF1_uc009zgx.2_RNA|KLRF1_uc001qwm.2_RNA|KLRF1_uc009zgy.2_RNA|KLRF1_uc009zgz.2_3'UTR|KLRF1_uc009zha.2_RNA	NM_016523	NP_057607	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F,	202	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			large_intestine(1)	1						CTTCATAAAGGGACCAGCTAA	0.348			NA											8	26					5.4927e-09	6.9164e-09	0.004482	1	0
GRIN2B	2904	broad.mit.edu	37	12	13724849	13724849	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:13724849G>T	uc001rbt.2	-	10	2239	c.2060C>A	c.(2059-2061)CCC>CAC	p.P687H		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	687	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCTGCCGTTGGGCACGGTCCC	0.378			NA											13	36					1.61879e-10	2.14227e-10	0.001368	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21032388	21032388	+	Missense_Mutation	SNP	C	C	G	rs138702607		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:21032388C>G	uc001rek.2	+	10	1280	c.1154C>G	c.(1153-1155)ACG>AGG	p.T385R	SLCO1B3_uc001rel.2_Missense_Mutation_p.T385R|SLCO1B3_uc010sil.1_Missense_Mutation_p.T385R|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.T210R	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	385	Helical; Name=8; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					ACCATTCCTACGGTTGCAACT	0.274			NA											9	43					0	0	0.006214	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21229503	21229503	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:21229503G>T	uc010sil.1	+	15	2113	c.2048G>T	c.(2047-2049)GGA>GTA	p.G683V	LST-3TM12_uc010sim.1_Missense_Mutation_p.G622V|LST-3TM12_uc010sin.1_Missense_Mutation_p.G575V			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					ACATATTTGGGGTAAGTTGTC	0.299			NA											30	45					2.47511e-08	3.06035e-08	0.008361	1	0
KCNJ8	3764	broad.mit.edu	37	12	21919111	21919111	+	Missense_Mutation	SNP	C	C	T	rs149127157		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:21919111C>T	uc001rff.2	-	3	1159	c.821G>A	c.(820-822)CGC>CAC	p.R274H		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	274	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	CAGGGGACTGCGCTTGTCAAT	0.473			NA											6	21					0	0	0.001168	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			17	21					1.96292e-10	2.59312e-10	0.010504	1	0
TMTC1	83857	broad.mit.edu	37	12	29669326	29669326	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:29669326G>T	uc001rjb.2	-	15	2413	c.1939C>A	c.(1939-1941)CGC>AGC	p.R647S	TMTC1_uc001riz.2_Missense_Mutation_p.R404S|TMTC1_uc001rja.2_Missense_Mutation_p.R491S|TMTC1_uc001riy.2_Missense_Mutation_p.R100S	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	755	TPR 8.					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GACAAGAGGCGATAGCATTCA	0.453			NA											31	72					2.70662e-09	3.46025e-09	0.009535	1	0
TMTC1	83857	broad.mit.edu	37	12	29904683	29904683	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:29904683C>T	uc001rjb.2	-	5	1004	c.530G>A	c.(529-531)TGG>TAG	p.W177*	TMTC1_uc001rjc.1_Nonsense_Mutation_p.W177*	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	285						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GCAGCCACCCCAAGCTCCTTT	0.507			NA											16	39					0	0	0.00499	0	0
IPO8	10526	broad.mit.edu	37	12	30816432	30816432	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:30816432G>C	uc001rjd.2	-	14	1755	c.1585C>G	c.(1585-1587)CAG>GAG	p.Q529E	IPO8_uc001rje.1_Missense_Mutation_p.Q18E|IPO8_uc010sjt.1_Missense_Mutation_p.Q324E	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	529					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CCTTGTATCTGGTTAGAAATT	0.378			NA											6	68					0	0	0.001168	0	0
DENND5B	160518	broad.mit.edu	37	12	31576610	31576610	+	Splice_Site	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:31576610C>A	uc001rki.1	-	11	2578	c.2392_splice	c.e11-1	p.G798_splice	DENND5B_uc001rkh.1_Splice_Site_p.G833_splice|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B							integral to membrane				ovary(1)|central_nervous_system(1)	2						CCGACTTCCCCTGAAAGTACA	0.343			NA											89	110					1.10192e-24	1.8688e-24	0.00361	1	0
H3F3C	440093	broad.mit.edu	37	12	31944715	31944715	+	Missense_Mutation	SNP	C	C	A	rs147097287		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:31944715C>A	uc001rkr.2	-	1	461	c.386G>T	c.(385-387)CGG>CTG	p.R129L		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	129					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCCCCGTATCCGGCGAGCCAA	0.438			NA								HNSCC(67;0.2)			93	92					1.02827e-36	1.89313e-36	0.00361	1	0
ABCD2	225	broad.mit.edu	37	12	39967542	39967542	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:39967542G>T	uc001rmb.2	-	9	2405	c.1979C>A	c.(1978-1980)TCT>TAT	p.S660Y		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	660	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						GTGTGTTATAGACAGTAAGGA	0.368			NA											36	46					2.87052e-16	4.29722e-16	0.005524	1	0
CNTN1	1272	broad.mit.edu	37	12	41337488	41337488	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:41337488G>T	uc001rmm.1	+	13	1582	c.1469G>T	c.(1468-1470)AGA>ATA	p.R490I	CNTN1_uc009zjy.1_Missense_Mutation_p.R490I|CNTN1_uc001rmn.1_Missense_Mutation_p.R479I|CNTN1_uc001rmo.2_Missense_Mutation_p.R490I	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	490	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAAAATAACAGAGGGAAAGCT	0.348			NA											24	61					4.26978e-12	5.84571e-12	0.00333	1	0
CNTN1	1272	broad.mit.edu	37	12	41410654	41410654	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:41410654G>T	uc001rmm.1	+	19	2468	c.2355G>T	c.(2353-2355)AAG>AAT	p.K785N	CNTN1_uc001rmn.1_Missense_Mutation_p.K774N	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	785	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTAAAGTCAAGGCCTTCAACA	0.423			NA											27	87					2.85442e-18	4.37755e-18	0.010818	1	0
DBX2	440097	broad.mit.edu	37	12	45429822	45429822	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:45429822G>T	uc001rok.1	-	2	651	c.479C>A	c.(478-480)GCA>GAA	p.A160E		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	160						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		agtggaggatgcagggcgccg	0.119			NA											14	14					4.75885e-15	6.86478e-15	0.00499	1	0
KRT84	3890	broad.mit.edu	37	12	52778922	52778922	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:52778922G>A	uc001sah.1	-	1	496	c.448C>T	c.(448-450)CTC>TTC	p.L150F		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	150	Head.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCAGGTTGAGGGGGGTCAGT	0.527			NA											18	307					0	0	0.008871	0	0
KRT5	3852	broad.mit.edu	37	12	52908997	52908997	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:52908997C>A	uc001san.2	-	9	1665	c.1502G>T	c.(1501-1503)GGA>GTA	p.G501V		NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	501	Tail.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		actgccATATCCAGAGGAAAC	0.264			NA											10	35					0.00829132	0.00875647	0.008291	1	0
SOAT2	8435	broad.mit.edu	37	12	53514665	53514665	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:53514665C>A	uc001sbv.2	+	11	1223	c.1135C>A	c.(1135-1137)CGG>AGG	p.R379R	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	379					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						GATGTTCTACCGGGTGGGGCC	0.557			NA											45	66					1.35964e-18	2.1153e-18	0.00361	1	0
GPR84	53831	broad.mit.edu	37	12	54757386	54757386	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:54757386G>T	uc001sfu.2	-	2	340	c.250C>A	c.(250-252)CTG>ATG	p.L84M		NM_020370	NP_065103	Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	84	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)	2						CGCCAGTGCAGGTGGAGGTAG	0.582			NA											11	25					0.000978159	0.00105979	0.010729	1	0
TIMELESS	8914	broad.mit.edu	37	12	56814763	56814763	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:56814763T>A	uc001slf.2	-	24	3192	c.3024A>T	c.(3022-3024)CAA>CAT	p.Q1008H		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	1008			Q -> E (in a breast cancer sample; somatic mutation).		cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin		p.Q1008E(1)		ovary(5)|breast(2)|pancreas(1)	8						GATGCAGGCTTTGACCAAGGT	0.498			NA											35	101					0	0	0.005524	0	0
PTPRB	5787	broad.mit.edu	37	12	70974892	70974892	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:70974892G>A	uc001swb.3	-	8	1878	c.1848C>T	c.(1846-1848)GGC>GGT	p.G616G	PTPRB_uc010sto.1_Silent_p.G616G|PTPRB_uc010stp.1_Silent_p.G526G|PTPRB_uc001swc.3_Silent_p.G834G|PTPRB_uc001swa.3_Silent_p.G834G|PTPRB_uc001swd.3_Silent_p.G833G|PTPRB_uc009zrr.1_Silent_p.G713G	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	616	Fibronectin type-III 7.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGTACAGGCTGCCGGACTTGA	0.458			NA											70	85					0	0	0.00361	0	0
PTPRB	5787	broad.mit.edu	37	12	70983910	70983910	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:70983910G>T	uc001swb.3	-	6	1260	c.1230C>A	c.(1228-1230)ATC>ATA	p.I410I	PTPRB_uc010sto.1_Silent_p.I410I|PTPRB_uc010stp.1_Intron|PTPRB_uc001swc.3_Silent_p.I628I|PTPRB_uc001swa.3_Silent_p.I628I|PTPRB_uc001swd.3_Silent_p.I627I|PTPRB_uc009zrr.1_Silent_p.I507I	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	410	Fibronectin type-III 5.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGAAGAGTAGGATCCGATACT	0.512			NA									OREG0021990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	80					1.31131e-34	2.38505e-34	0.013114	1	0
NAV3	89795	broad.mit.edu	37	12	78579461	78579461	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:78579461G>T	uc001syp.2	+	31	5946	c.5773G>T	c.(5773-5775)GGC>TGC	p.G1925C	NAV3_uc001syo.2_Missense_Mutation_p.G1903C|NAV3_uc010sub.1_Missense_Mutation_p.G1382C|NAV3_uc009zsf.2_Missense_Mutation_p.G734C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1925						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CATAAGCAAGGGCTATGGTCG	0.333			NA								HNSCC(70;0.22)			12	28					2.27111e-07	2.74062e-07	0.001368	1	0
MYF6	4618	broad.mit.edu	37	12	81102680	81102680	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:81102680G>T	uc001szf.1	+	3	723	c.670G>T	c.(670-672)GAC>TAC	p.D224Y		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	224					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TTCCATCGTGGACAGTATTTC	0.512			NA											38	86					1.47244e-24	2.49157e-24	0.00623	1	0
LUM	4060	broad.mit.edu	37	12	91502248	91502248	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:91502248C>A	uc001tbm.2	-	2	898	c.509G>T	c.(508-510)CGG>CTG	p.R170L	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	170	LRR 5.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						CTCTTTCAGCCGATTGTGCTG	0.443			NA											28	109					5.61819e-17	8.47795e-17	0.005443	1	0
FAM71C	196472	broad.mit.edu	37	12	100042084	100042084	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:100042084C>A	uc001tgn.2	+	1	554	c.132C>A	c.(130-132)CCC>CCA	p.P44P	ANKS1B_uc001tge.1_Intron|ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Intron	NM_153364	NP_699195	Q8NEG0	FA71C_HUMAN	hypothetical protein LOC196472	44											0				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		GGTATGCACCCATGTTTGAGA	0.522			NA											12	89					0.00136819	0.00146969	0.001368	1	0
GOLGA2B	55592	broad.mit.edu	37	12	100551393	100551393	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:100551393C>A	uc001tgs.2	-	4	647	c.203G>T	c.(202-204)AGG>ATG	p.R68M	GOLGA2B_uc001tgt.2_RNA|GOLGA2B_uc001tgu.2_Missense_Mutation_p.R68M|uc001tgx.2_5'Flank	NM_017600	NP_060070			golgi autoantigen, golgin subfamily a, 2-like 1												0						GGGCTGCTGCCTCAGGTTCCT	0.647			NA											28	37					1.50538e-07	1.82243e-07	0.00632	1	0
UTP20	27340	broad.mit.edu	37	12	101689353	101689353	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:101689353C>A	uc001tia.1	+	12	1503	c.1347C>A	c.(1345-1347)CTC>CTA	p.L449L		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	449					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TGGCCAAGCTCATTCTGAACA	0.433			NA											12	43					2.80697e-09	3.5764e-09	0.010729	1	0
SYCP3	50511	broad.mit.edu	37	12	102131607	102131607	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:102131607C>G	uc001tiq.2	-	2	239	c.107G>C	c.(106-108)AGT>ACT	p.S36T	SYCP3_uc001tir.2_Missense_Mutation_p.S36T|SYCP3_uc001tis.2_Missense_Mutation_p.S36T	NM_153694	NP_710161	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	36					cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding				0						CTCTGATCCACTCAGATCTTT	0.423			NA											10	200					0	0	0.008291	0	0
BTBD11	121551	broad.mit.edu	37	12	108010922	108010922	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:108010922C>A	uc001tmk.1	+	8	2579	c.2058C>A	c.(2056-2058)AAC>AAA	p.N686K	BTBD11_uc009zut.1_Missense_Mutation_p.N686K|BTBD11_uc001tmj.2_Missense_Mutation_p.N686K|BTBD11_uc001tml.1_Missense_Mutation_p.N223K	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	686						integral to membrane	DNA binding			skin(2)|ovary(1)	3						GCGAGGAGAACTACTCGGAAA	0.612			NA											23	68					1.42536e-11	1.93386e-11	0.004656	1	0
CUX2	23316	broad.mit.edu	37	12	111729244	111729244	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:111729244G>A	uc001tsa.1	+	5	477	c.324G>A	c.(322-324)GCG>GCA	p.A108A	CUX2_uc001tsb.1_Silent_p.A163A	NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	108						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TGTTTGAGGCGGCACGCAGCC	0.652			NA											11	93					0	0	0.010729	0	0
NAA25	80018	broad.mit.edu	37	12	112516017	112516017	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:112516017C>A	uc001ttm.2	-	7	659	c.639G>T	c.(637-639)TTG>TTT	p.L213F	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.L185F|NAA25_uc009zwa.1_Missense_Mutation_p.L213F	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	213						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TGATGACATCCAAGGCCTCCT	0.299			NA											35	53					1.38162e-09	1.77233e-09	0.00874	1	0
C12orf51	283450	broad.mit.edu	37	12	112681285	112681285	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:112681285C>A	uc009zwc.2	-	25	3582	c.3564G>T	c.(3562-3564)AGG>AGT	p.R1188S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CCCGCCGCCACCTTGTCTGTG	0.592			NA											6	7					8.12818e-05	9.16246e-05	0.001984	1	0
NOS1	4842	broad.mit.edu	37	12	117681107	117681107	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:117681107G>T	uc001twm.1	-	19	3643	c.2957C>A	c.(2956-2958)ACA>AAA	p.T986K		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	986					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGTACCTTGTGTGAGTTCTGG	0.517	Esophageal Squamous(162;1748 2599 51982 52956)		NA											34	40					3.33393e-15	4.85581e-15	0.004878	1	0
KDM2B	84678	broad.mit.edu	37	12	122018776	122018777	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr12:122018776_122018777GG>AA	uc001uat.2	-	1	144_145	c.40_41CC>TT	c.(40-42)CCC>TTC	p.P14F	KDM2B_uc001uas.2_5'Flank|KDM2B_uc001uau.2_5'UTR|KDM2B_uc001uav.3_Missense_Mutation_p.P14F	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	14					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						TTTTCGTGGGGGGTGATCCTCT	0.48			NA											81	83					0	0	0.004672	0	0
RNF17	56163	broad.mit.edu	37	13	25416251	25416251	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:25416251G>T	uc001upr.2	+	19	2596	c.2555G>T	c.(2554-2556)AGT>ATT	p.S852I	RNF17_uc010tdd.1_Missense_Mutation_p.S711I|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.S852I|RNF17_uc001ups.2_Missense_Mutation_p.S791I|RNF17_uc010aac.2_Missense_Mutation_p.S50I|RNF17_uc010aad.2_5'Flank	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	852					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		ACTACTACTAGTATTAATGAC	0.348			NA											38	43					2.54651e-27	4.41825e-27	0.006999	1	0
PABPC3	5042	broad.mit.edu	37	13	25671243	25671243	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:25671243G>A	uc001upy.2	+	1	968	c.907G>A	c.(907-909)GAT>AAT	p.D303N		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	303	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAATCTTGATGATGGTATTGA	0.428			NA											125	173					0	0	0.00361	0	0
WASF3	10810	broad.mit.edu	37	13	27255238	27255238	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:27255238A>G	uc001uqv.2	+	8	989	c.764A>G	c.(763-765)AAC>AGC	p.N255S	WASF3_uc001uqw.2_Missense_Mutation_p.N252S	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	255					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		GCTACTCCCAACCATTCTCTG	0.527			NA											16	72					0	0	0.007413	0	0
GPR12	2835	broad.mit.edu	37	13	27333098	27333098	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:27333098G>T	uc010aal.2	-	2	1089	c.867C>A	c.(865-867)CCC>CCA	p.P289P	GPR12_uc010tdl.1_Silent_p.P130P	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	289	Helical; Name=7; (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		TGTAGGTGGCGGGCAGGAGGG	0.522			NA											26	24					1.5548e-18	2.39911e-18	0.005443	1	0
FLT1	2321	broad.mit.edu	37	13	28964084	28964084	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:28964084C>A	uc001usb.3	-	13	2103	c.1818G>T	c.(1816-1818)AAG>AAT	p.K606N	FLT1_uc010aar.1_Missense_Mutation_p.K606N|FLT1_uc001usc.3_Missense_Mutation_p.K606N|FLT1_uc010aas.1_RNA|FLT1_uc010aat.1_Missense_Mutation_p.K89N	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	606	Ig-like C2-type 6.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CCATTTTTTGCTTGCTAATAC	0.413			NA											40	117					7.53189e-24	1.26314e-23	0.007835	1	0
FRY	10129	broad.mit.edu	37	13	32745165	32745165	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:32745165G>A	uc001utx.2	+	18	2405	c.1909G>A	c.(1909-1911)GAT>AAT	p.D637N	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	637					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TATTCATATGGATGATGAATT	0.333			NA											55	62					0	0	0.00361	0	0
KL	9365	broad.mit.edu	37	13	33635064	33635064	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:33635064G>A	uc001uus.2	+	4	1856	c.1848G>A	c.(1846-1848)CTG>CTA	p.L616L	KL_uc001uur.1_3'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	616	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACACCATCCTGCAGTACTATC	0.587			NA											13	65					0	0	0.004007	0	0
AKAP11	11215	broad.mit.edu	37	13	42869861	42869861	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:42869861G>T	uc001uys.1	+	5	374	c.199G>T	c.(199-201)GAT>TAT	p.D67Y		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	67					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGAAGAGACAGATGCTGCTCA	0.348			NA											37	50					6.48837e-15	9.30617e-15	0.010771	1	0
ZC3H13	23091	broad.mit.edu	37	13	46559672	46559672	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:46559672C>T	uc010tfw.1	-	9	1486	c.1480G>A	c.(1480-1482)GAT>AAT	p.D494N	ZC3H13_uc001vas.1_Missense_Mutation_p.D494N|ZC3H13_uc001vat.1_Missense_Mutation_p.D494N	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	494	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTCTGGGATCACGGCTCTCT	0.507	Esophageal Squamous(187;747 2077 11056 31291 44172)		NA											81	84					0	0	0.00361	0	0
PCDH17	27253	broad.mit.edu	37	13	58207805	58207805	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:58207805G>T	uc001vhq.1	+	1	2017	c.1125G>T	c.(1123-1125)CGG>CGT	p.R375R	PCDH17_uc010aec.1_Silent_p.R375R	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	375	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCCTGGTGCGGGTCACTGACC	0.567	Melanoma(72;952 1291 1619 12849 33676)		NA											7	26					2.0095e-06	2.34597e-06	0.001984	1	0
PCDH9	5101	broad.mit.edu	37	13	67800609	67800609	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:67800609C>G	uc001vik.2	-	2	2656	c.1964G>C	c.(1963-1965)CGT>CCT	p.R655P	PCDH9_uc001vil.2_Missense_Mutation_p.R655P|PCDH9_uc010thl.1_Missense_Mutation_p.R655P|PCDH9_uc001vin.3_Missense_Mutation_p.R655P	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	655	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		AGTAGAGGAACGAGGTGGTTG	0.438			NA											13	87					0	0	0.001855	0	0
KLHL1	57626	broad.mit.edu	37	13	70456619	70456619	+	Silent	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:70456619T>A	uc001vip.2	-	5	1817	c.1023A>T	c.(1021-1023)ATA>ATT	p.I341I	KLHL1_uc010thm.1_Silent_p.I280I	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	341					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TAACTTCCATTATGTTTTCCT	0.358			NA											4	27					0	0	0.000602	0	0
LMO7	4008	broad.mit.edu	37	13	76397701	76397701	+	Missense_Mutation	SNP	A	A	G	rs151245949		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:76397701A>G	uc001vjv.2	+	12	2702	c.1942A>G	c.(1942-1944)ATG>GTG	p.M648V	LMO7_uc010thv.1_Missense_Mutation_p.M599V|LMO7_uc001vjt.1_Missense_Mutation_p.M547V|LMO7_uc010thw.1_Missense_Mutation_p.M498V|LMO7_uc001vjw.1_Missense_Mutation_p.M554V	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	933						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TCTTATTTAGATGGATGATGC	0.313			NA											13	50					0	0	0.001855	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455264	84455264	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:84455264G>A	uc001vlk.2	-	1	1265	c.379C>T	c.(379-381)CTG>TTG	p.L127L		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	127	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCCAGCCCCAGAAAAGTCTGC	0.483			NA											19	107					0	0	0.010504	0	0
IPO5	3843	broad.mit.edu	37	13	98658478	98658478	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:98658478A>T	uc001vnf.1	+	14	1657	c.1592A>T	c.(1591-1593)TAT>TTT	p.Y531F	IPO5_uc001vne.2_Missense_Mutation_p.Y549F|IPO5_uc010tik.1_Missense_Mutation_p.Y406F|IPO5_uc010til.1_Missense_Mutation_p.Y471F|IPO5_uc001vng.1_Missense_Mutation_p.Y152F	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	531					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						GTCCCCTACTATGATTTATTT	0.388			NA											43	163					0	0	0.010771	0	0
FARP1	10160	broad.mit.edu	37	13	99092992	99092992	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:99092992C>G	uc001vnj.2	+	24	3034	c.2698C>G	c.(2698-2700)CTG>GTG	p.L900V	FARP1_uc001vnh.2_Missense_Mutation_p.L931V	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	900					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GCGCACATCGCTGGAGCGCCA	0.632			NA											8	25					0	0	0.00308	0	0
ZNF828	283489	broad.mit.edu	37	13	115090570	115090570	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:115090570A>C	uc010ahb.2	+	3	1582	c.1253A>C	c.(1252-1254)GAG>GCG	p.E418A	ZNF828_uc001vuv.2_Missense_Mutation_p.E418A|ZNF828_uc010tko.1_Missense_Mutation_p.E418A	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	418	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		GTGTCTCCAGAGCTTCGCAAA	0.557			NA											5	95					0	0	0.001168	0	0
P704P	641455	broad.mit.edu	37	14	20020002	20020002	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:20020002C>A	uc001vwc.3	-	1	271	c.219G>T	c.(217-219)AGG>AGT	p.R73S	P704P_uc001vwb.3_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	73											0						TGCCGCTCCCCCTGCACCAGG	0.582			NA											111	386					1.56149e-49	2.97672e-49	0.00361	1	0
OR4N5	390437	broad.mit.edu	37	14	20612049	20612049	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:20612049A>T	uc010tla.1	+	1	155	c.155A>T	c.(154-156)GAC>GTC	p.D52V		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		ATAAAGTCAGACCCTGGGCTC	0.463			NA											104	342					0	0	0.00361	0	0
PNP	4860	broad.mit.edu	37	14	20943064	20943064	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:20943064G>T	uc001vxo.3	+	4	560	c.418G>T	c.(418-420)GGT>TGT	p.G140C	PNP_uc010ahn.2_3'UTR|PNP_uc001vxn.3_Missense_Mutation_p.G11C	NM_000270	NP_000261	P00491	PNPH_HUMAN	nucleoside phosphorylase	140					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			ovary(2)	2					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	CAACCTACCTGGTTTCAGTGG	0.483			NA											32	93					2.09667e-21	3.43215e-21	0.003755	1	0
ATL1	51062	broad.mit.edu	37	14	51087337	51087337	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:51087337A>T	uc001wyf.3	+	9	1124	c.883A>T	c.(883-885)AAA>TAA	p.K295*	ATL1_uc001wyd.3_Nonsense_Mutation_p.K295*|ATL1_uc001wye.3_Nonsense_Mutation_p.K295*	NM_015915	NP_056999	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1 isoform a	295	Cytoplasmic.				axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4						TGAATTCATCAAAAACTTGAA	0.378			NA											8	124					0	0	0.008291	0	0
SAMD4A	23034	broad.mit.edu	37	14	55243227	55243227	+	Silent	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:55243227C>G	uc001xbb.2	+	10	2011	c.2010C>G	c.(2008-2010)TCC>TCG	p.S670S	SAMD4A_uc001xbc.2_Silent_p.S582S|SAMD4A_uc001xbg.2_Silent_p.S262S	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	671					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						TGCACACTTCCCCACAGAACA	0.612			NA											59	279					0	0	0.00361	0	0
DACT1	51339	broad.mit.edu	37	14	59112601	59112601	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:59112601G>A	uc001xdw.2	+	4	1424	c.1260G>A	c.(1258-1260)TCG>TCA	p.S420S	DACT1_uc010trv.1_Silent_p.S139S|DACT1_uc001xdx.2_Silent_p.S383S|DACT1_uc010trw.1_Silent_p.S139S	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	420					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						AGCAGTGGTCGAAAGAATCAA	0.567			NA											8	90					0	0	0.008291	0	0
PRKCH	5583	broad.mit.edu	37	14	61915900	61915900	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:61915900A>G	uc001xfn.2	+	5	937	c.632A>G	c.(631-633)CAT>CGT	p.H211R	PRKCH_uc010tsa.1_Missense_Mutation_p.H50R	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	211	Phorbol-ester/DAG-type 1.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		TGTGTCGTCCATAAACGCTGC	0.413	Melanoma(135;863 1779 8064 14443 26348)		NA											43	129					0	0	0.00361	0	0
NRXN3	9369	broad.mit.edu	37	14	79181120	79181120	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:79181120G>T	uc001xun.2	+	5	1054	c.563G>T	c.(562-564)AGG>ATG	p.R188M	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.R322M	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	561	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GTGAACAGCAGGCGCACGCCA	0.552			NA											98	295					1.45855e-51	2.80891e-51	0.00361	1	0
IFI27L1	122509	broad.mit.edu	37	14	94568239	94568239	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:94568239A>T	uc001ycl.2	+	4	349	c.141A>T	c.(139-141)GCA>GCT	p.A47A	IFI27L1_uc001yck.2_Silent_p.A47A	NM_206949	NP_996832	Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	47						integral to membrane					0						CCTCCATAGCAGCCAAGATGA	0.587			NA											55	34					0	0	0.00361	0	0
SERPINA5	5104	broad.mit.edu	37	14	95057199	95057199	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:95057199G>T	uc001ydm.2	+	5	1214	c.1004G>T	c.(1003-1005)GGC>GTC	p.G335V	SERPINA3_uc001ydo.3_5'Flank	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	335				G -> R (in Ref. 1; AAA35688 and 9; AAB26244).	fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GATCTGTCCGGCATCAGCAAC	0.448			NA											83	51					1.84514e-49	3.50856e-49	0.00361	1	0
TCL1A	8115	broad.mit.edu	37	14	96178706	96178706	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:96178706G>A	uc001yfc.3	-	2	278	c.148C>T	c.(148-150)CTC>TTC	p.L50F	TCL1A_uc001yfb.3_Missense_Mutation_p.L50F	NM_001098725	NP_001092195	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	50					multicellular organismal development	endoplasmic reticulum|microsome				lung(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		CGACGCAAGAGCACCCGTAAC	0.572	Ovarian(96;1068 2019 35393 39316)		NA	T	TRA@	T-CLL								17	135					0	0	0.006122	0	0
SETD3	84193	broad.mit.edu	37	14	99925494	99925494	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:99925494C>T	uc001ygc.2	-	5	544	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	SETD3_uc001ygd.2_Missense_Mutation_p.R125Q|SETD3_uc001ygf.2_Missense_Mutation_p.R125Q	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	125	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				TAGCAATTTTCGTGGAACCCA	0.343			NA											4	184					0	0	0.009096	0	0
RYR3	6263	broad.mit.edu	37	15	34064146	34064146	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:34064146C>A	uc001zhi.2	+	63	8912	c.8842C>A	c.(8842-8844)CTG>ATG	p.L2948M	RYR3_uc010bar.2_Missense_Mutation_p.L2948M	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2948	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGCTCAGAGCTGGTGAAGGC	0.448			NA											7	5					0.000157383	0.000175051	0.00308	1	0
SLC12A6	9990	broad.mit.edu	37	15	34530465	34530465	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:34530465T>A	uc001zhw.2	-	20	2934	c.2770A>T	c.(2770-2772)ATG>TTG	p.M924L	SLC12A6_uc001zhv.2_Missense_Mutation_p.M873L|SLC12A6_uc001zhx.2_Missense_Mutation_p.M909L|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.M865L|SLC12A6_uc001zib.2_Missense_Mutation_p.M915L|SLC12A6_uc001zic.2_Missense_Mutation_p.M924L|SLC12A6_uc010bau.2_Missense_Mutation_p.M924L|SLC12A6_uc001zid.2_Missense_Mutation_p.M865L|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.M736L	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	924	Helical; (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GGTAGTAGCATAAGCATCCCC	0.423			NA											21	44					0	0	0.00333	0	0
SPTBN5	51332	broad.mit.edu	37	15	42168805	42168805	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:42168805T>A	uc001zos.2	-	20	4120	c.3787A>T	c.(3787-3789)AGG>TGG	p.R1263W		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1298	Spectrin 9.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCCTGGAGCCTGGTCCACTGT	0.662			NA											3	11					0	0	0.004672	0	0
TP53BP1	7158	broad.mit.edu	37	15	43771675	43771676	+	Missense_Mutation	DNP	CT	CT	TA			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:43771675_43771676CT>TA	uc001zrs.2	-	7	840_841	c.692_693AG>TA	c.(691-693)CAG>CTA	p.Q231L	TP53BP1_uc010udp.1_Missense_Mutation_p.Q231L|TP53BP1_uc001zrq.3_Missense_Mutation_p.Q236L|TP53BP1_uc001zrr.3_Missense_Mutation_p.Q236L|TP53BP1_uc010udq.1_Missense_Mutation_p.Q236L	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	231					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CCTTGCTGGACTGTTCTGCTAT	0.401			NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					80	100					0	0	0.004672	0	0
TRIM69	140691	broad.mit.edu	37	15	45047534	45047534	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:45047534A>G	uc001zuf.2	+	3	1338	c.443A>G	c.(442-444)AAG>AGG	p.K148R	TRIM69_uc001zui.1_Intron|TRIM69_uc010bdy.1_Intron|TRIM69_uc001zug.1_Missense_Mutation_p.K148R|TRIM69_uc001zuh.1_Intron	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	148	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		GGGCAGTCTAAGGAGTTCCTG	0.468	Pancreas(84;519 1450 1802 20427 34706)		NA											17	44					0	0	0.008871	0	0
SLC24A5	283652	broad.mit.edu	37	15	48427124	48427124	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:48427124C>G	uc001zwe.2	+	5	606	c.533C>G	c.(532-534)GCG>GGG	p.A178G	SLC24A5_uc010bel.2_Missense_Mutation_p.A118G|uc001zwf.1_RNA	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	178	Helical; Name=4; (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		GACTGTGCAGCGTACACAATT	0.333			NA											18	39					0	0	0.012319	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397328	51397328	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:51397328A>G	uc001zyy.2	-	1	146	c.46T>C	c.(46-48)TGT>CGT	p.C16R		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	16											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		TCTGCCTCACAGAGTGTGGAA	0.512			NA											47	63					0	0	0.00361	0	0
UNC13C	440279	broad.mit.edu	37	15	54817797	54817797	+	Silent	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:54817797T>C	uc002ack.2	+	23	5508	c.5508T>C	c.(5506-5508)AGT>AGC	p.S1836S		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1836					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTAAGCTCAGTGGGGTCCTGG	0.373			NA											5	9					0	0	0.001168	0	0
VPS13C	54832	broad.mit.edu	37	15	62160902	62160902	+	Missense_Mutation	SNP	G	G	A	rs149574145		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:62160902G>A	uc002agz.2	-	81	10893	c.10819C>T	c.(10819-10821)CGT>TGT	p.R3607C	VPS13C_uc002aha.2_Missense_Mutation_p.R3564C|VPS13C_uc002ahb.1_Missense_Mutation_p.R3607C|VPS13C_uc002ahc.1_Missense_Mutation_p.R3564C	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3607					protein localization					ovary(2)	2						TCATAAGGACGAATGATGCCA	0.443			NA											15	29					0	0	0.008871	0	0
ZWILCH	55055	broad.mit.edu	37	15	66811350	66811350	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:66811350G>T	uc002aqb.2	+	5	700	c.454G>T	c.(454-456)GGA>TGA	p.G152*	RPL4_uc002apx.2_Intron|ZWILCH_uc010bhu.1_Nonsense_Mutation_p.G38*|ZWILCH_uc002aqa.2_Nonsense_Mutation_p.G38*|ZWILCH_uc010bhv.2_Nonsense_Mutation_p.G38*	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch	152					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						TTGTTGGCTAGGAGCTGAGCT	0.428			NA											19	83					6.33239e-15	9.11718e-15	0.010504	1	0
ITGA11	22801	broad.mit.edu	37	15	68657091	68657091	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:68657091C>A	uc002ari.2	-	4	398	c.311G>T	c.(310-312)CGC>CTC	p.R104L	ITGA11_uc010bib.2_Missense_Mutation_p.R104L	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	104	FG-GAP 2.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	AAGGCCGAGGCGCATGTTGTC	0.647			NA											7	40					2.52707e-12	3.49153e-12	0.006214	1	0
MYO9A	4649	broad.mit.edu	37	15	72190736	72190736	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr15:72190736G>A	uc002atl.3	-	25	4581	c.4108C>T	c.(4108-4110)CGG>TGG	p.R1370W	MYO9A_uc010biq.2_Missense_Mutation_p.R990W|MYO9A_uc002atn.1_Missense_Mutation_p.R1351W|MYO9A_uc002atk.2_Missense_Mutation_p.R94W|MYO9A_uc002atm.1_Missense_Mutation_p.R94W	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1370	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GCATTGTCCCGTGAATCAAAT	0.438			NA											26	80					0	0	0.004656	0	0
WDR90	197335	broad.mit.edu	37	16	705382	705382	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:705382C>T	uc002cii.1	+	15	1686	c.1632C>T	c.(1630-1632)GAC>GAT	p.D544D	WDR90_uc002cig.1_Silent_p.D544D|WDR90_uc002cih.1_Silent_p.D545D|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.D71D|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	544										ovary(1)	1		Hepatocellular(780;0.0218)				GCCCCGTGGACTTAGGGGAGC	0.697			NA											4	13					0	0	0.000602	0	0
MYH11	4629	broad.mit.edu	37	16	15818582	15818582	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:15818582G>T	uc002ddy.2	-	30	4145	c.4038C>A	c.(4036-4038)AAC>AAA	p.N1346K	MYH11_uc002ddv.2_Missense_Mutation_p.N1353K|MYH11_uc002ddw.2_Missense_Mutation_p.N1346K|MYH11_uc002ddx.2_Missense_Mutation_p.N1353K|MYH11_uc010bvg.2_Missense_Mutation_p.N1178K|NDE1_uc010uzy.1_3'UTR|NDE1_uc002dds.2_3'UTR|MYH11_uc010bvh.2_Missense_Mutation_p.N52K|NDE1_uc002ddz.1_RNA	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1346	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CTTGCAGGCTGTTCCGCTCCT	0.592			NA	T	CBFB	AML								64	171					1.52808e-22	2.54568e-22	0.00361	1	0
GPRC5B	51704	broad.mit.edu	37	16	19873217	19873217	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:19873217G>C	uc002dgt.2	-	3	1217	c.1109C>G	c.(1108-1110)CCG>CGG	p.P370R	GPRC5B_uc010vav.1_Missense_Mutation_p.P396R	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	370	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						GCTTCTAAACGGAGCGCTGGG	0.562			NA											34	73					0	0	0.003271	0	0
ACSM2B	348158	broad.mit.edu	37	16	20563612	20563612	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:20563612C>A	uc002dhj.3	-	7	958	c.748G>T	c.(748-750)GGC>TGC	p.G250C	ACSM2B_uc002dhk.3_Missense_Mutation_p.G250C|ACSM2B_uc010bwf.1_Missense_Mutation_p.G250C	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	250					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GCTTGCAGGCCTGTCCAACTG	0.473			NA											48	122					4.45325e-31	7.90873e-31	0.00361	1	0
EARS2	124454	broad.mit.edu	37	16	23540900	23540900	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:23540900C>A	uc002dlt.3	-	7	1307	c.1275G>T	c.(1273-1275)TGG>TGT	p.W425C	EARS2_uc002dlr.3_RNA|EARS2_uc002dls.3_RNA|EARS2_uc002dlu.2_Missense_Mutation_p.W425C	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2 precursor	425					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	CAGGGCGAGTCCACAGGTAAG	0.592			NA											11	43					1.58986e-06	1.86475e-06	0.008291	1	0
GTF3C1	2975	broad.mit.edu	37	16	27523148	27523148	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:27523148C>G	uc002dov.1	-	7	1088	c.1048G>C	c.(1048-1050)GAG>CAG	p.E350Q	GTF3C1_uc002dou.2_Missense_Mutation_p.E350Q	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	350	Asp/Glu-rich (acidic).					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ATGACCTCCTCGTCCTCGTCA	0.532			NA											29	47					0	0	0.00632	0	0
TRIM72	493829	broad.mit.edu	37	16	31230652	31230652	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:31230652G>T	uc002ebn.1	+	4	758	c.529G>T	c.(529-531)GGC>TGC	p.G177C	PYDC1_uc002ebo.2_5'Flank	NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	177					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						GGAGCAGCTGGGCAAGATGCG	0.667			NA											47	80					1.72184e-34	3.1242e-34	0.00361	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:32890622T>G	uc002edh.1	-	5	440	c.264A>C	c.(262-264)AAA>AAC	p.K88N	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						CGTTGGTGTTTTTGTAGACCA	0.512			NA											3	28					0	0	0.004672	0	0
ABCC11	85320	broad.mit.edu	37	16	48248819	48248819	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:48248819G>T	uc002eff.1	-	8	1571	c.1221C>A	c.(1219-1221)TCC>TCA	p.S407S	ABCC11_uc002efg.1_Silent_p.S407S|ABCC11_uc002efh.1_Silent_p.S407S|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	407	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TCAGCTTTAAGGATGTGTGGA	0.483			NA							Cerumen_Type				20	36					1.50039e-11	2.032e-11	0.012319	1	0
ZNF423	23090	broad.mit.edu	37	16	49670060	49670060	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:49670060C>G	uc002efs.2	-	5	3301	c.3003G>C	c.(3001-3003)GAG>GAC	p.E1001D	ZNF423_uc010vgn.1_Missense_Mutation_p.E884D	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1001					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CAATAAACTCCTCCTCGCTCT	0.597			NA											4	18					0	0	0.000602	0	0
FTO	79068	broad.mit.edu	37	16	53967990	53967990	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:53967990C>T	uc002ehr.2	+	8	1555	c.1333C>T	c.(1333-1335)CGC>TGC	p.R445C	FTO_uc010vha.1_Missense_Mutation_p.R149C|FTO_uc010cbz.2_Missense_Mutation_p.R46C|FTO_uc002ehs.2_RNA	NM_001080432	NP_001073901	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	445					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GCTCACTGCACGCCAGAACCT	0.468			NA											8	38					0	0	0.00308	0	0
MMP2	4313	broad.mit.edu	37	16	55519237	55519237	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:55519237G>C	uc002ehz.3	+	4	867	c.556G>C	c.(556-558)GGT>CGT	p.G186R	MMP2_uc010vhd.1_Missense_Mutation_p.G110R|MMP2_uc010ccc.2_Missense_Mutation_p.G136R	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	186	Collagenase-like 1.	Calcium 3; via carbonyl oxygen (By similarity).			angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CCCCTTTGACGGTAAGGACGG	0.562			NA											33	61					0	0	0.003755	0	0
NLRC5	84166	broad.mit.edu	37	16	57111715	57111715	+	Splice_Site	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:57111715G>T	uc002ekk.1	+	42	5228	c.5003_splice	c.e42+1	p.M1668_splice	NLRC5_uc010ccr.1_Splice_Site|NLRC5_uc010ccs.1_Splice_Site|NLRC5_uc002eko.1_Splice_Site|NLRC5_uc002ekq.1_Splice_Site_p.M210_splice|NLRC5_uc002ekr.1_Splice_Site_p.M555_splice	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27						defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AGGAGTTGATGTGAGTGTCTG	0.672			NA											18	22					0.00074312	0.00080746	0.006122	1	0
CES3	23491	broad.mit.edu	37	16	66998348	66998348	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:66998348G>A	uc002eqt.2	+	5	722	c.649G>A	c.(649-651)GGG>AGG	p.G217R	CES3_uc010cdz.2_Missense_Mutation_p.G217R|CES3_uc010cea.2_RNA	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	217						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		CGCCCCCTTCGGGGGTGACCT	0.582			NA											6	24					0	0	0.001168	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77317892	77317892	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:77317892G>T	uc002ffc.3	-	23	4046	c.3627C>A	c.(3625-3627)TAC>TAA	p.Y1209*		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1209	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						ATTGTTTTCCGTAAAACTTGT	0.458			NA											21	76					6.44725e-10	8.38477e-10	0.002299	1	0
FBXO39	162517	broad.mit.edu	37	17	6690699	6690699	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:6690699G>T	uc010vtg.1	+	4	1401	c.1281G>T	c.(1279-1281)CTG>CTT	p.L427L	FBXO39_uc010cls.1_Intron	NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	427										ovary(1)|skin(1)	2						ACAGAAAGCTGATCGAATCAG	0.398			NA											18	63					3.41278e-10	4.47705e-10	0.00499	1	0
ACAP1	9744	broad.mit.edu	37	17	7246801	7246801	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:7246801C>G	uc002ggd.2	+	6	654	c.448C>G	c.(448-450)CAG>GAG	p.Q150E		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	150	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						GCGCCGGGCCCAGGAGGCAGA	0.672			NA											13	56					0	0	0.00245	0	0
DNAH2	146754	broad.mit.edu	37	17	7638002	7638002	+	Silent	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:7638002T>C	uc002giu.1	+	6	968	c.954T>C	c.(952-954)TTT>TTC	p.F318F	DNAH2_uc002git.2_Silent_p.F318F|DNAH2_uc010vuk.1_Silent_p.F318F	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	318	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGGCGCCCTTTATGAAACTGG	0.512			NA											17	49					0	0	0.006122	0	0
MYH1	4619	broad.mit.edu	37	17	10397671	10397671	+	Silent	SNP	C	C	T	rs145273788	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:10397671C>T	uc002gmo.2	-	39	5761	c.5667G>A	c.(5665-5667)GCG>GCA	p.A1889A	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1889	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GTGAACTCACCGCTTCTTCAG	0.443			NA											35	67					0	0	0.003755	0	0
DNAH9	1770	broad.mit.edu	37	17	11837221	11837221	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:11837221C>T	uc002gne.2	+	65	12390	c.12322C>T	c.(12322-12324)CTG>TTG	p.L4108L	DNAH9_uc010coo.2_Silent_p.L3326L|DNAH9_uc002gnf.2_Silent_p.L420L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4108					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTTGCGCTACCTGTTTGGAGA	0.517			NA											10	50					0	0	0.006214	0	0
MYOCD	93649	broad.mit.edu	37	17	12656400	12656400	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:12656400C>A	uc002gnn.2	+	10	2094	c.1795C>A	c.(1795-1797)CCG>ACG	p.P599T	MYOCD_uc002gno.2_Missense_Mutation_p.P599T|MYOCD_uc002gnp.1_Missense_Mutation_p.P503T|MYOCD_uc002gnq.2_Missense_Mutation_p.P318T	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	599					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GTGTCACCCACCGGCTTGTGA	0.517			NA											28	62					4.02929e-09	5.12509e-09	0.010818	1	0
PIGS	94005	broad.mit.edu	37	17	26883184	26883184	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:26883184C>A	uc002hbo.2	-	10	1554	c.1181G>T	c.(1180-1182)CGG>CTG	p.R394L	PIGS_uc002hbn.2_Missense_Mutation_p.R386L|PIGS_uc010wap.1_Missense_Mutation_p.R333L	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	394	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					AGGACCTCACCGCAACTGTGC	0.512			NA											16	49					0.000308642	0.000339281	0.003163	1	0
CORO6	84940	broad.mit.edu	37	17	27948283	27948283	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:27948283C>G	uc002hel.2	-	1	159	c.157G>C	c.(157-159)GCT>CCT	p.A53P		NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	53					actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						CCGCCTCCAGCCTCCACAATA	0.602			NA											11	38					0	0	0.001368	0	0
SLFN5	162394	broad.mit.edu	37	17	33585721	33585721	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:33585721G>T	uc002hjf.3	+	2	129	c.12G>T	c.(10-12)AGG>AGT	p.R4S	SLFN5_uc002hje.2_Missense_Mutation_p.R4S|SLFN5_uc010wcg.1_Missense_Mutation_p.R4S	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	4					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TGAGTCTTAGGATTGATGTGG	0.463			NA											13	53					7.93312e-07	9.39252e-07	0.00245	1	0
KRT28	162605	broad.mit.edu	37	17	38955966	38955966	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:38955966G>A	uc002hvh.1	-	1	246	c.180C>T	c.(178-180)AGC>AGT	p.S60S		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	60	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CACCAGCATGGCTCCCACCAG	0.547	Melanoma(19;789 869 15380 26882 39836)		NA											47	33					0	0	0.00361	0	0
C17orf53	78995	broad.mit.edu	37	17	42232034	42232034	+	Splice_Site	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:42232034T>A	uc002ifi.1	+	6	1746	c.1561_splice	c.e6+2	p.G521_splice	C17orf53_uc010czq.1_Splice_Site_p.G520_splice|C17orf53_uc002ifj.1_Splice_Site_p.G445_splice|C17orf53_uc002ifk.1_Splice_Site	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995												0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		ACCCCACGGGTAAGGAATTAG	0.542			NA											9	46					0	0	0.004482	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42274678	42274678	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:42274678T>C	uc002iga.2	-	3	365	c.274A>G	c.(274-276)AGC>GGC	p.S92G	ATXN7L3_uc010wiv.1_5'Flank|ATXN7L3_uc002ifz.2_Missense_Mutation_p.S92G	NM_001098833	NP_001092303	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3 isoform b	92	SGF11-type.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCGGCAATGCTGCGACTGCAA	0.597			NA											22	118					0	0	0.002299	0	0
FMNL1	752	broad.mit.edu	37	17	43321390	43321390	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:43321390C>T	uc002iin.2	+	18	2646	c.2446C>T	c.(2446-2448)CCG>TCG	p.P816S	FMNL1_uc002iiq.2_Missense_Mutation_p.P394S|FMNL1_uc010dag.2_RNA	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	816	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						GCTGCTCATGCCGGTGTGGGC	0.672	GBM(164;1247 1997 8702 11086 51972)		NA											3	44					0	0	0.004672	0	0
HOXB2	3212	broad.mit.edu	37	17	46622233	46622233	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:46622233C>T	uc002inm.2	-	1	161	c.41G>A	c.(40-42)AGC>AAC	p.S14N		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	14					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGACGGCTGGCTGTTTATAAA	0.532			NA											15	76					0	0	0.00499	0	0
BRIP1	83990	broad.mit.edu	37	17	59760697	59760697	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:59760697G>A	uc002izk.1	-	20	3851	c.3710C>T	c.(3709-3711)TCT>TTT	p.S1237F		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1237					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						TTTGGAAGGAGATGGTTTAAA	0.294			NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				23	81					0	0	0.00333	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60348783	60348783	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:60348783C>G	uc002izq.2	-	6	434	c.322G>C	c.(322-324)GGC>CGC	p.G108R	TBC1D3P2_uc010woz.1_RNA|uc010wpa.1_5'Flank					SubName: Full=Putative uncharacterized protein TBC1D3E;												0						CACATCGGGCCCCGGATGTTC	0.552			NA											21	69					0	0	0.004878	0	0
USP36	57602	broad.mit.edu	37	17	76831480	76831480	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:76831480G>A	uc002jvz.1	-	4	682	c.357C>T	c.(355-357)CGC>CGT	p.R119R	USP36_uc002jwa.1_Silent_p.R119R|USP36_uc002jwd.1_Silent_p.R119R	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	119					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CTGCGCCCACGCGGAAGACCC	0.592			NA											13	16					0	0	0.004007	0	0
LAMA1	284217	broad.mit.edu	37	18	7008579	7008579	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:7008579T>A	uc002knm.2	-	28	4124	c.4030A>T	c.(4030-4032)AGA>TGA	p.R1344*	LAMA1_uc010wzj.1_Nonsense_Mutation_p.R820*	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1344	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCAGCCTTTCTGCCAACCTCC	0.443			NA											13	68					0	0	0.003163	0	0
LAMA1	284217	broad.mit.edu	37	18	7023336	7023336	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:7023336C>A	uc002knm.2	-	19	2622	c.2528G>T	c.(2527-2529)GGC>GTC	p.G843V	LAMA1_uc010wzj.1_Missense_Mutation_p.G319V	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	843	Laminin EGF-like 7.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACAAGATTCGCCAGGCACTGT	0.527			NA											9	32					1.76689e-08	2.1955e-08	0.006214	1	0
CEP192	55125	broad.mit.edu	37	18	13030600	13030600	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:13030600A>T	uc010xac.1	+	11	1607	c.1527A>T	c.(1525-1527)AGA>AGT	p.R509S	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.R104S|CEP192_uc002kru.2_RNA|CEP192_uc002krs.1_Intron	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	509										ovary(4)|pancreas(1)	5						AAGACTTCAGATCTGGTTGTA	0.343			NA											11	93					0	0	0.001368	0	0
C18orf1	753	broad.mit.edu	37	18	13645402	13645402	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:13645402A>C	uc002ksa.2	+	7	1335	c.667A>C	c.(667-669)ATG>CTG	p.M223L	C18orf1_uc002ksb.2_Missense_Mutation_p.M205L|C18orf1_uc002kse.2_Missense_Mutation_p.M186L|C18orf1_uc002ksf.2_Missense_Mutation_p.M168L|C18orf1_uc002ksg.1_Missense_Mutation_p.M146L|C18orf1_uc002ksh.1_Missense_Mutation_p.M165L|C18orf1_uc002ksi.1_Missense_Mutation_p.M147L	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	223	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		AGACATTGCTATGTATAGCGG	0.577			NA											8	86					0	0	0.004482	0	0
LAMA3	3909	broad.mit.edu	37	18	21508618	21508618	+	Silent	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:21508618A>C	uc002kuq.2	+	64	8411	c.8325A>C	c.(8323-8325)GGA>GGC	p.G2775G	LAMA3_uc002kur.2_Silent_p.G2719G|LAMA3_uc002kus.3_Silent_p.G1166G|LAMA3_uc002kut.3_Silent_p.G1110G	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2775	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCCAGAGGAGGACAATTGA	0.428			NA											41	333					0	0	0.00361	0	0
ZNF521	25925	broad.mit.edu	37	18	22805191	22805191	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:22805191C>A	uc002kvk.2	-	4	2938	c.2691G>T	c.(2689-2691)ATG>ATT	p.M897I	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.M897I|ZNF521_uc002kvl.2_Missense_Mutation_p.M677I	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	897	C2H2-type 21; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GCAAAGTTTCCATAGTGTAGG	0.502			NA	T	PAX5	ALL								28	122					3.73148e-12	5.12738e-12	0.007291	1	0
DSG2	1829	broad.mit.edu	37	18	29099836	29099836	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:29099836G>T	uc002kwu.3	+	3	340	c.152G>T	c.(151-153)TGG>TTG	p.W51L		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	51	Extracellular (Potential).|Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AAGCGCGCCTGGATCACCGCC	0.433			NA											95	41					9.15355e-43	1.71458e-42	0.00361	1	0
ASXL3	80816	broad.mit.edu	37	18	31323007	31323007	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:31323007G>T	uc010dmg.1	+	12	3250	c.3195G>T	c.(3193-3195)CGG>CGT	p.R1065R	ASXL3_uc002kxq.2_Silent_p.R772R	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1065	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AACAAGCTCGGGCCCAGCGAG	0.612			NA											8	49					0.00448238	0.00476055	0.004482	1	0
SLC14A2	8170	broad.mit.edu	37	18	43247835	43247835	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:43247835C>A	uc010dnj.2	+	15	2076	c.1755C>A	c.(1753-1755)CTC>CTA	p.L585L	SLC14A2_uc002lbe.2_Silent_p.L585L	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	585						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						ACTGGGTCCTCCGAGGCACAT	0.577			NA											120	42					3.13773e-49	5.95142e-49	0.00361	1	0
LIPG	9388	broad.mit.edu	37	18	47108730	47108730	+	Splice_Site	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:47108730A>T	uc002ldv.2	+	7	1289	c.1037_splice	c.e7-2	p.V346_splice	LIPG_uc010xdh.1_Splice_Site_p.V272_splice	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor						cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CTGTCACTGCAGTTTACCATT	0.448	Pancreas(126;280 1778 12814 26243 34948)		NA											81	47					0	0	0.00361	0	0
MYO5B	4645	broad.mit.edu	37	18	47455928	47455928	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:47455928C>G	uc002leb.2	-	17	2332	c.2044G>C	c.(2044-2046)GGG>CGG	p.G682R		NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	682	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TCCAACACCCCGCAGGCTCTG	0.527			NA											16	8					0	0	0.008871	0	0
MAPK4	5596	broad.mit.edu	37	18	48256146	48256147	+	Missense_Mutation	DNP	CG	CG	TC			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:48256146_48256147CG>TC	uc002lev.2	+	6	2686_2687	c.1686_1687CG>TC	c.(1684-1689)GGCGAC>GGTCAC	p.D563H	MAPK4_uc010xdm.1_Missense_Mutation_p.D352H|MAPK4_uc010doz.2_3'UTR	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	563					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		ATAAACTGGGCGACCTCAATGG	0.668			NA											9	6					0	0	0.004672	0	0
ALPK2	115701	broad.mit.edu	37	18	56184325	56184325	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:56184325C>T	uc002lhj.3	-	9	5969	c.5755G>A	c.(5755-5757)GCC>ACC	p.A1919T		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1919	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TCCTCCGTGGCGATCTGACCA	0.547			NA											5	93					0	0	0.000602	0	0
CDH20	28316	broad.mit.edu	37	18	59195340	59195340	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:59195340C>A	uc010dps.1	+	6	1170	c.1158C>A	c.(1156-1158)CCC>CCA	p.P386P	CDH20_uc002lif.2_Silent_p.P380P	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	386	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TGGACGAGCCCCCTGTGTTTG	0.512			NA											28	216					3.65163e-15	5.27769e-15	0.00632	1	0
SERPINB7	8710	broad.mit.edu	37	18	61460397	61460397	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:61460397A>T	uc002ljl.2	+	4	318	c.222A>T	c.(220-222)TCA>TCT	p.S74S	SERPINB7_uc002ljm.2_Silent_p.S74S|SERPINB7_uc010xet.1_Silent_p.S57S|SERPINB7_uc010dqg.2_Silent_p.S74S	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	74					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				AATAACAGTCAGGGCTCCAGT	0.313			NA											6	79					0	0	0.001984	0	0
NETO1	81832	broad.mit.edu	37	18	70417782	70417782	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:70417782G>C	uc002lkw.2	-	9	1340	c.1056C>G	c.(1054-1056)ATC>ATG	p.I352M	NETO1_uc002lkx.1_Missense_Mutation_p.I351M|NETO1_uc002lky.1_Missense_Mutation_p.I352M	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	352	Helical; (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGATGATCACGATGCAGGAAG	0.463			NA											62	16					0	0	0.00361	0	0
MIER2	54531	broad.mit.edu	37	19	336131	336131	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:336131G>T	uc002lok.1	-	2	61	c.52C>A	c.(52-54)CTC>ATC	p.L18I		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGTGCTCGAGGCAGGAGACC	0.657			NA											21	26					2.39556e-15	3.50264e-15	0.00278	1	0
MED16	10025	broad.mit.edu	37	19	881589	881589	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:881589C>A	uc002lqd.1	-	7	1262	c.1111G>T	c.(1111-1113)GCC>TCC	p.A371S	MED16_uc010drw.1_Missense_Mutation_p.A196S|MED16_uc002lqe.2_Missense_Mutation_p.A360S|MED16_uc002lqf.2_Missense_Mutation_p.A360S|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.A360S|MED16_uc010xfx.1_Missense_Mutation_p.A216S|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	371					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTCGCTGGCCACCTTGAGG	0.657			NA											62	24					5.86059e-21	9.49037e-21	0.00361	1	0
GTF2F1	2962	broad.mit.edu	37	19	6380419	6380419	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:6380419T>G	uc002meq.2	-	13	1712	c.1427A>C	c.(1426-1428)AAG>ACG	p.K476T	GTF2F1_uc010xjb.1_Missense_Mutation_p.K297T|GTF2F1_uc010xjc.1_Missense_Mutation_p.K391T	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	476					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GGTCTGGAACTTTTTCAGCAG	0.587			NA											7	121					0	0	0.001984	0	0
MAST1	22983	broad.mit.edu	37	19	12963015	12963015	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:12963015C>A	uc002mvm.2	+	9	1091	c.963C>A	c.(961-963)CCC>CCA	p.P321P	MAST1_uc002mvk.2_Silent_p.P317P	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	321					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CGGACATCCCCCGCTACATCA	0.667			NA											51	27					7.47603e-22	1.23453e-21	0.00361	1	0
ZNF626	199777	broad.mit.edu	37	19	20808333	20808333	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:20808333C>A	uc002npb.1	-	4	500	c.350G>T	c.(349-351)TGT>TTT	p.C117F	ZNF626_uc002npc.1_Missense_Mutation_p.C41F	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CACACTTATACATCCTTTTTT	0.338			NA											43	27					1.03325e-14	1.47915e-14	0.011902	1	0
ZFP30	22835	broad.mit.edu	37	19	38126960	38126960	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:38126960C>A	uc002ogv.1	-	6	998	c.482G>T	c.(481-483)GGG>GTG	p.G161V	ZFP30_uc002ogw.1_Missense_Mutation_p.G161V|ZFP30_uc002ogx.1_Missense_Mutation_p.G161V|ZFP30_uc010xtt.1_Missense_Mutation_p.G160V	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	161	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCCACATTCCCCACATTCGTA	0.393			NA											43	91					2.215e-12	3.06599e-12	0.011902	1	0
RYR1	6261	broad.mit.edu	37	19	38995661	38995661	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:38995661G>A	uc002oit.2	+	52	8380	c.8250G>A	c.(8248-8250)AAG>AAA	p.K2750K	RYR1_uc002oiu.2_Silent_p.K2750K|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2750	5.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCCCGGAGAAGCTGGACTCCT	0.562			NA											10	63					0	0	0.010729	0	0
MAP3K10	4294	broad.mit.edu	37	19	40710446	40710446	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:40710446C>T	uc002ona.2	+	3	1206	c.918C>T	c.(916-918)ATC>ATT	p.I306I	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	306	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						ACCGTGAGATCGACGCCTTGG	0.667			NA											21	32					0	0	0.002299	0	0
PSG9	5678	broad.mit.edu	37	19	43763045	43763045	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:43763045C>A	uc002owd.3	-	4	1051	c.952G>T	c.(952-954)GGC>TGC	p.G318C	PSG9_uc002owe.3_Intron|PSG9_uc010xwm.1_Missense_Mutation_p.G225C|PSG9_uc002owf.3_Intron|PSG9_uc002owg.2_Intron|PSG9_uc002owh.2_Intron	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	318	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				CTGCGGAGGCCACCATATCGG	0.493			NA											64	105					6.20203e-27	1.06381e-26	0.00361	1	0
PLAUR	5329	broad.mit.edu	37	19	44171830	44171830	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:44171830C>A	uc002oxf.1	-	2	299	c.69G>T	c.(67-69)CTG>CTT	p.L23L	PLAUR_uc002oxd.1_Silent_p.L23L|PLAUR_uc002oxe.1_Silent_p.L18L|PLAUR_uc002oxg.1_Silent_p.L23L	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	23	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	GCATGCACCGCAGGCCCCAAG	0.612			NA											10	25					7.48243e-07	8.88686e-07	0.006214	1	0
ZNF223	7766	broad.mit.edu	37	19	44570525	44570525	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:44570525G>T	uc002oyf.1	+	5	797	c.544G>T	c.(544-546)GGA>TGA	p.G182*	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	182	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				TGATGAGTGTGGAAAAAGCTT	0.428			NA											65	168					4.96364e-44	9.32076e-44	0.00361	1	0
ZNF234	10780	broad.mit.edu	37	19	44662182	44662182	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:44662182C>A	uc002oym.2	+	6	2320	c.2013C>A	c.(2011-2013)CAC>CAA	p.H671Q	ZNF234_uc002oyl.3_Missense_Mutation_p.H671Q	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	671	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				TAAGTCATCACAAAATTCATG	0.368			NA											24	44					1.10923e-09	1.42778e-09	0.00278	1	0
ZNF227	7770	broad.mit.edu	37	19	44739572	44739572	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:44739572G>T	uc002oyu.2	+	6	1194	c.989G>T	c.(988-990)GGC>GTC	p.G330V	ZNF227_uc010xwu.1_Missense_Mutation_p.G279V|ZNF227_uc002oyv.2_Missense_Mutation_p.G330V|ZNF227_uc010xwv.1_Missense_Mutation_p.G279V|ZNF227_uc010xww.1_Missense_Mutation_p.G251V|ZNF227_uc002oyw.2_Missense_Mutation_p.G302V|ZNF227_uc010ejh.2_Missense_Mutation_p.G323V|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	330	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				GACAGTTGCGGCAAGGGATTC	0.388			NA											33	66					1.08052e-11	1.4713e-11	0.004289	1	0
PGLYRP1	8993	broad.mit.edu	37	19	46526132	46526132	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:46526132G>T	uc002pdx.1	-	1	192	c.148C>A	c.(148-150)CTG>ATG	p.L50M		NM_005091	NP_005082	O75594	PGRP1_HUMAN	peptidoglycan recognition protein 1 precursor	50					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region	bacterial cell surface binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)	2		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		GGCAGGCTCAGGTGCTGGGCG	0.662			NA											4	10					0.00024832	0.000274978	0.009096	1	0
GRWD1	83743	broad.mit.edu	37	19	48956135	48956135	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:48956135C>T	uc002pjd.2	+	7	1427	c.1194C>T	c.(1192-1194)CCC>CCT	p.P398P	KCNJ14_uc002pje.1_5'Flank	NM_031485	NP_113673	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	398						nucleolus				ovary(1)	1		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		AGGCCGACCCCGGACTGGCCG	0.692			NA											18	19					0	0	0.008871	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49376608	49376608	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:49376608G>T	uc002pky.3	+	2	387	c.118G>T	c.(118-120)GGA>TGA	p.G40*		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	40	Required for localization in the endoplasmic reticulum.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GAGGGGCCTGGGACCTCTAGA	0.637			NA											16	33					1.78486e-19	2.82948e-19	0.007413	1	0
KLK1	3816	broad.mit.edu	37	19	51323520	51323520	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:51323520G>C	uc002ptk.1	-	3	425	c.386C>G	c.(385-387)CCT>CGT	p.P129R	KLK1_uc010ycg.1_RNA	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein	129	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTATCAGCAGGCTCTGTCAG	0.602			NA											33	83					0	0	0.013114	0	0
SIGLEC6	946	broad.mit.edu	37	19	52023450	52023450	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:52023450G>T	uc002pwy.2	-	8	1410	c.1248C>A	c.(1246-1248)CCC>CCA	p.P416P	SIGLEC6_uc002pwz.2_Silent_p.P400P|SIGLEC6_uc002pxa.2_3'UTR|SIGLEC6_uc010ydb.1_Silent_p.P353P|SIGLEC6_uc010ydc.1_3'UTR|SIGLEC6_uc010eoz.1_3'UTR	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	416	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CTTCTGAGATGGGGCCAGCCT	0.507			NA											93	183					6.84326e-50	1.30786e-49	0.00361	1	0
SIGLEC6	946	broad.mit.edu	37	19	52031048	52031048	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:52031048C>A	uc002pwy.2	-	7	1303	c.1141G>T	c.(1141-1143)GTG>TTG	p.V381L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.V365L|SIGLEC6_uc002pxa.2_Intron|SIGLEC6_uc010ydb.1_Missense_Mutation_p.V318L|SIGLEC6_uc010ydc.1_Intron|SIGLEC6_uc010eoz.1_Intron	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	381	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GTGTTTTGCACTGGCTGGGCT	0.488			NA											32	160					2.68265e-12	3.6997e-12	0.002836	1	0
VN1R2	317701	broad.mit.edu	37	19	53762292	53762292	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:53762292C>G	uc002qbi.2	+	1	748	c.664C>G	c.(664-666)CTG>GTG	p.L222V		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	222	Helical; Name=4; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		CTTCCACATGCTGGTAAATGC	0.448			NA											30	50					0	0	0.012213	0	0
LILRB2	10288	broad.mit.edu	37	19	54783311	54783311	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:54783311C>T	uc002qfb.2	-	5	813	c.547G>A	c.(547-549)GTG>ATG	p.V183M	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.V183M|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.V183M|LILRB2_uc010yet.1_Missense_Mutation_p.V67M|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	183	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACGGGGCCCACGGAGAAGATG	0.572			NA											8	85					0	0	0.006214	0	0
LAIR2	3904	broad.mit.edu	37	19	55014160	55014160	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:55014160T>C	uc002qgc.2	+	1	148	c.26T>C	c.(25-27)CTG>CCG	p.L9P	LAIR2_uc002qga.1_Intron|LAIR2_uc002qgb.1_Intron|LAIR2_uc002qgd.2_Missense_Mutation_p.L9P|LAIR2_uc010erl.2_Missense_Mutation_p.L9P	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	9						extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		ACTGCTCTCCTGGGCCTAGGT	0.622			NA											27	62					0	0	0.012213	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55340893	55340893	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:55340893C>A	uc002qhk.3	+	7	1141	c.1078C>A	c.(1078-1080)CTT>ATT	p.L360I	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.L285I|KIR3DL1_uc010esf.2_Missense_Mutation_p.L265I|KIR3DL1_uc010yfo.1_Missense_Mutation_p.L302I|KIR3DL1_uc002qhl.3_Intron	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	360	Helical; (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		cttctttctccttcatctcTG	0.433			NA											9	24					1.49906e-05	1.7181e-05	0.00245	1	0
SAPS1	22870	broad.mit.edu	37	19	55753604	55753604	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:55753604C>A	uc002qjw.3	-	7	1017	c.775G>T	c.(775-777)GAG>TAG	p.E259*	SAPS1_uc002qjv.2_Nonsense_Mutation_p.E321*	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	259	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TGGCTCTGCTCCCCCTCGAAC	0.652			NA											49	90					9.55421e-19	1.48951e-18	0.00361	1	0
NLRP13	126204	broad.mit.edu	37	19	56410252	56410252	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:56410252G>T	uc010ygg.1	-	10	2866	c.2841C>A	c.(2839-2841)GCC>GCA	p.A947A		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	947							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TATGGCTGAGGGCATTAGCCA	0.438			NA											42	68					5.48756e-27	9.4341e-27	0.011902	1	0
NLRP13	126204	broad.mit.edu	37	19	56424608	56424608	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:56424608C>T	uc010ygg.1	-	5	600	c.575G>A	c.(574-576)TGG>TAG	p.W192*		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	192							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GATGTTGTCCCATGTCTCCAG	0.443			NA											58	151					0	0	0.00361	0	0
NLRP13	126204	broad.mit.edu	37	19	56424611	56424611	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:56424611G>T	uc010ygg.1	-	5	597	c.572C>A	c.(571-573)ACA>AAA	p.T191K		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	191							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTTGTCCCATGTCTCCAGTAG	0.443			NA											57	147					5.5144e-22	9.12604e-22	0.00361	1	0
NLRP8	126205	broad.mit.edu	37	19	56459432	56459432	+	Missense_Mutation	SNP	G	G	A	rs145268550		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:56459432G>A	uc002qmh.2	+	1	235	c.164G>A	c.(163-165)CGG>CAG	p.R55Q	NLRP8_uc010etg.2_Missense_Mutation_p.R55Q	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	55	DAPIN.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGCTACAACGGTTCAAGCAG	0.547			NA											6	19					0	0	0.001168	0	0
NLRP5	126206	broad.mit.edu	37	19	56539728	56539728	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:56539728T>G	uc002qmj.2	+	7	2129	c.2129T>G	c.(2128-2130)GTG>GGG	p.V710G	NLRP5_uc002qmi.2_Missense_Mutation_p.V691G	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	710	LRR 1.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTCCAAGAAGTGTGGCTTCCG	0.498			NA											81	134					0	0	0.00361	0	0
NLRP5	126206	broad.mit.edu	37	19	56544988	56544988	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:56544988A>T	uc002qmj.2	+	9	2528	c.2528A>T	c.(2527-2529)AAC>ATC	p.N843I	NLRP5_uc002qmi.2_Missense_Mutation_p.N824I	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	843	LRR 5.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AGATCCCTCAACTTGGGAGGC	0.502			NA											93	130					0	0	0.00361	0	0
PEG3	5178	broad.mit.edu	37	19	57330040	57330040	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:57330040G>A	uc002qnu.2	-	5	1051	c.700C>T	c.(700-702)CTC>TTC	p.L234F	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.L109F|ZIM2_uc002qnq.2_Missense_Mutation_p.L109F|ZIM2_uc010etp.2_Missense_Mutation_p.L109F|ZIM2_uc010ygs.1_Missense_Mutation_p.L109F|PEG3_uc002qnt.2_Missense_Mutation_p.L235F|PEG3_uc002qnv.2_Missense_Mutation_p.L234F|PEG3_uc002qnw.2_Missense_Mutation_p.L109F|PEG3_uc002qnx.2_Missense_Mutation_p.L108F|PEG3_uc010etr.2_Missense_Mutation_p.L234F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	234					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCCTCAGCGAGGTCCACCACA	0.483			NA											46	86					0	0	0.00361	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58849788	58849788	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:58849788G>T	uc002qsc.2	+	3	719	c.572G>T	c.(571-573)GGG>GTG	p.G191V	ZSCAN22_uc010yhz.1_Missense_Mutation_p.G186W	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	191					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GGACTATCAGGGGAGATCTGG	0.532			NA											22	56					9.95505e-16	1.46409e-15	0.002299	1	0
RRM2	6241	broad.mit.edu	37	2	10269234	10269234	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:10269234A>G	uc002rah.2	+	9	1161	c.970A>G	c.(970-972)ATT>GTT	p.I324V		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	324					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		GAAGCAATACATTGAGTTTGT	0.413			NA											72	124					0	0	0.00361	0	0
WDR35	57539	broad.mit.edu	37	2	20180465	20180465	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:20180465C>A	uc002rdi.2	-	4	402	c.294G>T	c.(292-294)TGG>TGT	p.W98C	WDR35_uc002rdj.2_Missense_Mutation_p.W98C|WDR35_uc010ext.2_RNA	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	98	WD 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATATAACATCCACACAATGA	0.333			NA											24	50					4.4004e-07	5.27628e-07	0.00333	1	0
APOB	338	broad.mit.edu	37	2	21233989	21233989	+	Silent	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:21233989G>C	uc002red.2	-	26	5879	c.5751C>G	c.(5749-5751)CTC>CTG	p.L1917L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1917					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCCAGAGAGCGAGTTTCCCAT	0.443			NA											88	179					0	0	0.00361	0	0
OTOF	9381	broad.mit.edu	37	2	26702462	26702462	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:26702462C>G	uc002rhk.2	-	17	2099	c.1972G>C	c.(1972-1974)GAG>CAG	p.E658Q	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	658	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCCCCGGCTCCTTCCGGGGC	0.622	GBM(102;732 1451 20652 24062 31372)		NA											24	36					0	0	0.005443	0	0
CAD	790	broad.mit.edu	37	2	27456644	27456644	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:27456644G>T	uc002rji.2	+	21	3529	c.3367G>T	c.(3367-3369)GTG>TTG	p.V1123L	CAD_uc010eyw.2_Missense_Mutation_p.V1060L	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1123	CPSase B.|ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AGAGCATCCCGTGGTCATCTC	0.587			NA											14	43					3.52763e-06	4.08663e-06	0.00499	1	0
BIRC6	57448	broad.mit.edu	37	2	32724814	32724814	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:32724814G>T	uc010ezu.2	+	46	8803	c.8669G>T	c.(8668-8670)CGA>CTA	p.R2890L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2890					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GTGGGTGCTCGAGCATGCTTT	0.438	Pancreas(94;175 1509 16028 18060 45422)		NA											83	153					1.55023e-36	2.84021e-36	0.00361	1	0
LTBP1	4052	broad.mit.edu	37	2	33585790	33585790	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:33585790C>A	uc002ros.2	+	27	4130	c.4130C>A	c.(4129-4131)TCA>TAA	p.S1377*	LTBP1_uc002rot.2_Nonsense_Mutation_p.S1051*|LTBP1_uc002rou.2_Nonsense_Mutation_p.S1050*|LTBP1_uc002rov.2_Nonsense_Mutation_p.S997*|LTBP1_uc010ymz.1_Nonsense_Mutation_p.S1008*|LTBP1_uc010yna.1_Nonsense_Mutation_p.S955*|LTBP1_uc010ynb.1_Nonsense_Mutation_p.S274*	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1376	TB 3.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGCTGTACATCAGGCGTGGGA	0.468			NA											37	54					1.836e-18	2.82722e-18	0.003755	1	0
TMEM178	130733	broad.mit.edu	37	2	39931220	39931220	+	Splice_Site	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:39931220G>T	uc002rrt.2	+	2	426	c.401_splice	c.e2-1	p.G134_splice	TMEM178_uc010fam.1_Splice_Site_p.G134_splice	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor							integral to membrane					0		all_hematologic(82;0.248)				TTTCCTTCAAGGTATTGCGCA	0.443			NA											12	24					9.31168e-06	1.07212e-05	0.001855	1	0
SIX2	10736	broad.mit.edu	37	2	45236176	45236176	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:45236176C>A	uc002ruo.2	-	1	367	c.74G>T	c.(73-75)GGC>GTC	p.G25V	SIX2_uc002rup.2_Missense_Mutation_p.G25V	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	25						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTCGATGTTGCCGCCCTGCTG	0.617			NA											3	12					0.00909568	0.0095258	0.009096	1	0
ZNF638	27332	broad.mit.edu	37	2	71591170	71591170	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:71591170G>T	uc002shx.2	+	5	1824	c.1505G>T	c.(1504-1506)AGT>ATT	p.S502I	ZNF638_uc010fec.2_Missense_Mutation_p.S608I|ZNF638_uc010yqw.1_Missense_Mutation_p.S81I|ZNF638_uc002shw.2_Missense_Mutation_p.S502I|ZNF638_uc002shy.2_Missense_Mutation_p.S502I|ZNF638_uc002shz.2_Missense_Mutation_p.S502I|ZNF638_uc002sia.2_Missense_Mutation_p.S502I|ZNF638_uc002sib.1_Missense_Mutation_p.S502I|ZNF638_uc010fed.2_5'Flank	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	502	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TCAAGCTCAAGTCACAGATTC	0.458			NA											28	76					5.45727e-16	8.08922e-16	0.008361	1	0
ALMS1	7840	broad.mit.edu	37	2	73675761	73675761	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:73675761G>T	uc002sje.1	+	10	2221	c.2110G>T	c.(2110-2112)GAC>TAC	p.D704Y	ALMS1_uc002sjf.1_Missense_Mutation_p.D660Y|ALMS1_uc002sjg.2_Missense_Mutation_p.D90Y|ALMS1_uc002sjh.1_Missense_Mutation_p.D90Y	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	702	4.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TGGACCAGCTGACCAGAAGAC	0.478			NA											50	93					6.81593e-30	1.20762e-29	0.00361	1	0
REG3G	130120	broad.mit.edu	37	2	79253910	79253910	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:79253910C>A	uc002snw.2	+	3	233	c.148C>A	c.(148-150)CCC>ACC	p.P50T	REG3G_uc002snx.2_Missense_Mutation_p.P50T|REG3G_uc010ffu.2_Missense_Mutation_p.P50T	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	50	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						CTATGGCTCCCCCTGCTATGC	0.522			NA											23	35					2.32416e-17	3.53554e-17	0.002299	1	0
CTNNA2	1496	broad.mit.edu	37	2	79878763	79878763	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:79878763G>T	uc010ysh.1	+	1	86	c.81G>T	c.(79-81)CTG>CTT	p.L27L	CTNNA2_uc010yse.1_Silent_p.L27L|CTNNA2_uc010ysf.1_Silent_p.L27L|CTNNA2_uc010ysg.1_Silent_p.L27L|hsa-mir-4264|MI0015877_5'Flank	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	27					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TGGAAAGGCTGTTGGAGCCAC	0.423			NA											32	36					1.26612e-14	1.80908e-14	0.003271	1	0
CTNNA2	1496	broad.mit.edu	37	2	80816498	80816498	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:80816498G>C	uc010ysh.1	+	14	2082	c.2077G>C	c.(2077-2079)GAG>CAG	p.E693Q	CTNNA2_uc010yse.1_Missense_Mutation_p.E693Q|CTNNA2_uc010ysf.1_Missense_Mutation_p.E693Q|CTNNA2_uc010ysg.1_Missense_Mutation_p.E693Q|CTNNA2_uc010ysi.1_Missense_Mutation_p.E325Q|CTNNA2_uc010ysj.1_Missense_Mutation_p.E22Q	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	693					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						ATTCCATCAAGAGAAAAGCAA	0.488			NA											22	52					0	0	0.010504	0	0
SNRNP200	23020	broad.mit.edu	37	2	96945230	96945230	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:96945230C>A	uc002svu.2	-	36	5178	c.5092G>T	c.(5092-5094)GAT>TAT	p.D1698Y	SNRNP200_uc002svt.2_Missense_Mutation_p.D308Y|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1698	Helicase C-terminal 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CGCCCCTCATCGTCCTGCAAA	0.532			NA											9	16					7.48243e-07	8.88686e-07	0.006214	1	0
RGPD3	653489	broad.mit.edu	37	2	107049613	107049613	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:107049613A>C	uc010ywi.1	-	16	2391	c.2334T>G	c.(2332-2334)CAT>CAG	p.H778Q		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	778					intracellular transport		binding			ovary(1)	1						ATGGTGTAGAATGTTTTATTT	0.353			NA											32	192					0	0	0.00361	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459835	107459835	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:107459835G>A	uc002tdq.2	-	2	718	c.599C>T	c.(598-600)TCC>TTC	p.S200F	ST6GAL2_uc002tdr.2_Missense_Mutation_p.S200F|ST6GAL2_uc002tds.3_Missense_Mutation_p.S200F	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	200	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GAAGGCCCTGGACATGGAGGA	0.612			NA											26	49					0	0	0.00333	0	0
EDAR	10913	broad.mit.edu	37	2	109545663	109545663	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:109545663C>T	uc002teq.3	-	4	778	c.347G>A	c.(346-348)TGC>TAC	p.C116Y	EDAR_uc010fjn.2_Missense_Mutation_p.C116Y|EDAR_uc010yws.1_Missense_Mutation_p.C116Y	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	116	TNFR-Cys 3.|Extracellular (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						CCCAGGGAGGCAAGGGCCACA	0.607			NA											8	26					0	0	0.008291	0	0
CCDC93	54520	broad.mit.edu	37	2	118698795	118698795	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:118698795G>C	uc002tlj.2	-	19	1618	c.1492C>G	c.(1492-1494)CAG>GAG	p.Q498E	CCDC93_uc010fld.1_Missense_Mutation_p.Q498E	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	498										large_intestine(1)|ovary(1)	2						AATCTCTTCTGATACTGTATT	0.478			NA											40	79					0	0	0.013114	0	0
IWS1	55677	broad.mit.edu	37	2	128252492	128252492	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:128252492C>A	uc002ton.2	-	8	2058	c.1755G>T	c.(1753-1755)CTG>CTT	p.L585L	IWS1_uc010yzl.1_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	585					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TTAATTTTTTCAGTGCTGGCT	0.259			NA											25	58					7.38237e-10	9.55141e-10	0.00632	1	0
MYO7B	4648	broad.mit.edu	37	2	128322932	128322933	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:128322932_128322933TG>CT	uc002top.2	+	4	310_311	c.257_258TG>CT	c.(256-258)CTG>CCT	p.L86P		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	86	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CACAACCTCCTGATCCGCTACC	0.594			NA											16	30					0	0	0.004672	0	0
POTEE	445582	broad.mit.edu	37	2	131984447	131984447	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:131984447G>A	uc002tsn.2	+	4	914	c.862G>A	c.(862-864)GTG>ATG	p.V288M	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Translation_Start_Site|POTEE_uc002tsl.2_Translation_Start_Site	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	288	ANK 4.						ATP binding				0						ACAGCAAGTCGTGAAATTTTT	0.333			NA											29	129					0	0	0.00623	0	0
YSK4	80122	broad.mit.edu	37	2	135745412	135745412	+	Missense_Mutation	SNP	C	C	A	rs145468662		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:135745412C>A	uc002tue.1	-	7	1061	c.1030G>T	c.(1030-1032)GTT>TTT	p.V344F	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.V231F|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.V72F|YSK4_uc002tui.3_Missense_Mutation_p.V361F	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	344							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCTTCCCTAACTGCAGGAATA	0.373			NA											25	33					9.57634e-11	1.28309e-10	0.00333	1	0
TANC1	85461	broad.mit.edu	37	2	160020007	160020007	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:160020007A>T	uc002uag.2	+	8	1170	c.896A>T	c.(895-897)TAT>TTT	p.Y299F	TANC1_uc010fol.1_Missense_Mutation_p.Y193F|TANC1_uc010zcm.1_Missense_Mutation_p.Y298F|TANC1_uc010fom.1_Intron	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	299						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCAGTCCCTTATTCTCAGGGC	0.557			NA											17	36					0	0	0.006122	0	0
BAZ2B	29994	broad.mit.edu	37	2	160287467	160287467	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:160287467G>A	uc002uao.2	-	10	2453	c.2101C>T	c.(2101-2103)CCA>TCA	p.P701S	BAZ2B_uc002uap.2_Missense_Mutation_p.P699S|BAZ2B_uc002uaq.1_Intron|BAZ2B_uc002uar.1_Missense_Mutation_p.P274S	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	701					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GCAGAGCCTGGGGCTTTTGCT	0.463			NA											39	82					0	0	0.007835	0	0
XIRP2	129446	broad.mit.edu	37	2	168101499	168101499	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:168101499C>A	uc002udx.2	+	8	3615	c.3597C>A	c.(3595-3597)AGC>AGA	p.S1199R	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S1024R|XIRP2_uc010fpq.2_Missense_Mutation_p.S977R|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1024	Xin 19.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATGTTTCCAGCATGAGGTATA	0.333			NA											23	31					2.70639e-06	3.14493e-06	0.002299	1	0
STK39	27347	broad.mit.edu	37	2	168996894	168996894	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:168996894C>A	uc002uea.2	-	7	905	c.745G>T	c.(745-747)GGC>TGC	p.G249C		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	249	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						AAGTCATAGCCTCTCACCTAA	0.413			NA											20	23					1.64113e-05	1.87808e-05	0.010504	1	0
HOXD10	3236	broad.mit.edu	37	2	176982209	176982209	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:176982209G>A	uc002ukj.2	+	1	718	c.648G>A	c.(646-648)GTG>GTA	p.V216V		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	216						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		TCTCCCAGGTGGAGAGCCCCG	0.642			NA											3	26					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179459155	179459155	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:179459155C>A	uc010zfg.1	-	245	50586	c.50362G>T	c.(50362-50364)GAG>TAG	p.E16788*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E10483*|TTN_uc010zfi.1_Nonsense_Mutation_p.E10416*|TTN_uc010zfj.1_Nonsense_Mutation_p.E10291*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17715							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACGGTACTCATAGGTATCA	0.413			NA											17	86					2.35188e-11	3.17947e-11	0.006122	1	0
TTN	7273	broad.mit.edu	37	2	179460446	179460446	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:179460446C>A	uc010zfg.1	-	244	50155	c.49931G>T	c.(49930-49932)GGA>GTA	p.G16644V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G10339V|TTN_uc010zfi.1_Missense_Mutation_p.G10272V|TTN_uc010zfj.1_Missense_Mutation_p.G10147V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17571							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGAGAGCCTCCATCATCTTC	0.458			NA											6	8					8.12818e-05	9.16246e-05	0.001984	1	0
TTN	7273	broad.mit.edu	37	2	179546142	179546142	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:179546142C>A	uc010zfg.1	-	134	29700	c.29476G>T	c.(29476-29478)GTG>TTG	p.V9826L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V6487L|TTN_uc010fre.1_Intron|TTN_uc002una.1_5'Flank|TTN_uc010frf.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10753							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAATGGGCACTGGTACTTTT	0.348			NA											8	16					0.000274275	0.000302385	0.004482	1	0
DNAH7	56171	broad.mit.edu	37	2	196913024	196913024	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:196913024G>A	uc002utj.3	-	4	347	c.246C>T	c.(244-246)TCC>TCT	p.S82S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	82	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCTTACCATGGGACTGTTCAT	0.368			NA											24	31					0	0	0.004656	0	0
ICA1L	130026	broad.mit.edu	37	2	203644316	203644316	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:203644316C>T	uc002uzh.1	-	14	1553	c.1389G>A	c.(1387-1389)TTG>TTA	p.L463L	ICA1L_uc002uzi.1_Silent_p.L463L	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	463											0						AAAGTGGATCCAAGTCTGCAA	0.378			NA											24	31					0	0	0.00632	0	0
CD28	940	broad.mit.edu	37	2	204599581	204599581	+	Silent	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:204599581C>G	uc002vah.3	+	4	831	c.609C>G	c.(607-609)CGC>CGG	p.R203R	CD28_uc010zio.1_RNA|CD28_uc010ftx.2_Silent_p.R84R|CD28_uc002vaj.3_RNA	NM_006139	NP_006130	P10747	CD28_HUMAN	CD28 antigen precursor	203	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity				0						GGCCCACCCGCAAGCATTACC	0.622			NA											14	61					0	0	0.001855	0	0
DYTN	391475	broad.mit.edu	37	2	207527692	207527692	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:207527692T>C	uc002vbr.1	-	11	1685	c.1568A>G	c.(1567-1569)GAG>GGG	p.E523G		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	523	Potential.|Poly-Glu.					plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TTCCTCTTCCTCCAGCTCATC	0.463			NA											4	192					0	0	0.001168	0	0
MAP2	4133	broad.mit.edu	37	2	210558179	210558179	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:210558179A>T	uc002vde.1	+	7	1533	c.1285A>T	c.(1285-1287)AGT>TGT	p.S429C	MAP2_uc002vdc.1_Missense_Mutation_p.S429C|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.S425C	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	429					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TTTCACCCCCAGTGGACAGGA	0.418	Pancreas(27;423 979 28787 29963)		NA											22	26					0	0	0.00278	0	0
UNC80	285175	broad.mit.edu	37	2	210642131	210642131	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:210642131C>A	uc010zjc.1	+	4	528	c.448C>A	c.(448-450)CAC>AAC	p.H150N	UNC80_uc002vdj.1_Missense_Mutation_p.H150N	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	chromosome 2 open reading frame 21 isoform 1	150						integral to membrane					0						TGCTTTCATCCACCAGGTTGA	0.552			NA											14	50					9.31168e-06	1.07212e-05	0.001855	1	0
MRPL44	65080	broad.mit.edu	37	2	224828609	224828609	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:224828609G>A	uc002vnr.3	+	3	854	c.785G>A	c.(784-786)GGT>GAT	p.G262D		NM_022915	NP_075066	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44 precursor	262	DRBM.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			central_nervous_system(1)	1		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGGCAGTCTGGTGGCACCACA	0.373			NA											34	37					0	0	0.005524	0	0
DGKD	8527	broad.mit.edu	37	2	234370997	234370997	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:234370997C>A	uc002vui.1	+	25	2997	c.2985C>A	c.(2983-2985)ATC>ATA	p.I995I	DGKD_uc002vuj.1_Silent_p.I951I|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	995					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	TCTCTAGTATCCGAGAAATAG	0.567			NA											5	35					0.000602214	0.00065911	0.000602	1	0
PRR21	643905	broad.mit.edu	37	2	240982289	240982289	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:240982289G>T	uc010zod.1	-	1	111	c.111C>A	c.(109-111)CAC>CAA	p.H37Q		NM_001080835	NP_001074304	Q8WXC7	PRR21_HUMAN	proline rich 21	37										ovary(1)|skin(1)	2						AGGGCCATGGGTGAAGAGCCG	0.572			NA											6	9					8.12818e-05	9.16246e-05	0.001984	1	0
ANKMY1	51281	broad.mit.edu	37	2	241463637	241463637	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:241463637C>A	uc002vyz.1	-	7	1459	c.1230G>T	c.(1228-1230)GAG>GAT	p.E410D	ANKMY1_uc002vza.1_Missense_Mutation_p.E269D|ANKMY1_uc010fzd.1_Missense_Mutation_p.E499D|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Missense_Mutation_p.E269D|ANKMY1_uc002vzd.1_Missense_Mutation_p.E269D|ANKMY1_uc010fze.1_Missense_Mutation_p.E79D|ANKMY1_uc002vze.2_Missense_Mutation_p.E171D	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	410							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		AGTGGCCGCCCTCGTGGCTGC	0.642			NA											15	44					4.93089e-13	6.87585e-13	0.00245	1	0
CAPN10	11132	broad.mit.edu	37	2	241530258	241530258	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:241530258G>T	uc002vzk.1	+	3	484	c.300G>T	c.(298-300)TGG>TGT	p.W100C	CAPN10_uc010zoh.1_Missense_Mutation_p.W100C|CAPN10_uc002vzl.1_Missense_Mutation_p.W100C|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_5'UTR|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	100	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		AGCCGAGCTGGGCCGACCAGG	0.637			NA											9	27					0.000274275	0.000302385	0.004482	1	0
PASK	23178	broad.mit.edu	37	2	242066563	242066563	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:242066563C>A	uc002wao.1	-	10	1859	c.1767G>T	c.(1765-1767)GGG>GGT	p.G589G	PASK_uc010zol.1_Silent_p.G403G|PASK_uc010zom.1_Silent_p.G554G|PASK_uc010fzl.1_Silent_p.G589G|PASK_uc010zon.1_Silent_p.G370G|PASK_uc002wap.2_Silent_p.G132G|PASK_uc002waq.2_Silent_p.G589G	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	589					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CCACGGCAGCCCCAGCCCAAA	0.647			NA											26	38					1.64293e-13	2.31672e-13	0.00333	1	0
TGM3	7053	broad.mit.edu	37	20	2321104	2321104	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:2321104G>T	uc002wfx.3	+	13	2056	c.1959G>T	c.(1957-1959)GAG>GAT	p.E653D		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	653					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GGCCCAAGGAGGGGTCCCGGG	0.612			NA											24	113					2.2171e-23	3.70172e-23	0.009535	1	0
PROKR2	128674	broad.mit.edu	37	20	5283097	5283097	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:5283097C>A	uc010zqw.1	-	2	744	c.744G>T	c.(742-744)CGG>CGT	p.R248R	PROKR2_uc010zqx.1_Silent_p.R248R|PROKR2_uc010zqy.1_Silent_p.R248R	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	248	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ACCAGAGCTCCCGGGAGATCC	0.577			NA								HNSCC(71;0.22)			22	34					9.95505e-16	1.46409e-15	0.002299	1	0
PLCB4	5332	broad.mit.edu	37	20	9459601	9459601	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:9459601G>T	uc002wnf.2	+	37	3629	c.3493G>T	c.(3493-3495)GCC>TCC	p.A1165S	PLCB4_uc010gbx.2_Missense_Mutation_p.A1177S|PLCB4_uc002wne.2_Missense_Mutation_p.S1177I|PLCB4_uc002wnh.2_Missense_Mutation_p.A1012S	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	1165					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GAAATTGGAAGCCGAGATGGA	0.448			NA											8	24					7.48243e-07	8.88686e-07	0.006214	1	0
PAK7	57144	broad.mit.edu	37	20	9525048	9525048	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:9525048C>A	uc002wnl.2	-	9	2382	c.1837G>T	c.(1837-1839)GAG>TAG	p.E613*	PAK7_uc002wnk.2_Nonsense_Mutation_p.E613*|PAK7_uc002wnj.2_Nonsense_Mutation_p.E613*|PAK7_uc010gby.1_Intron	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	613	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GAAATCACCTCAGGGGCCATC	0.502			NA											75	67					1.356e-25	2.31011e-25	0.00361	1	0
NINL	22981	broad.mit.edu	37	20	25485607	25485607	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:25485607C>A	uc002wux.1	-	6	699	c.625G>T	c.(625-627)GGG>TGG	p.G209W	NINL_uc010gdn.1_Missense_Mutation_p.G209W|NINL_uc010gdo.1_Missense_Mutation_p.G49W|NINL_uc010ztf.1_Missense_Mutation_p.G225W	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	209	EF-hand 3.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CTGCCCACCCCCAGCTCTTCC	0.657			NA											12	35					7.03913e-09	8.8341e-09	0.001368	1	0
DEFB115	245929	broad.mit.edu	37	20	29845536	29845536	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:29845536G>T	uc002wvp.1	+	1	70	c.70G>T	c.(70-72)GTG>TTG	p.V24L		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	24					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			AGTTGTCCTTGTGGTCCTGGC	0.512			NA											37	34					1.30015e-28	2.27677e-28	0.004878	1	0
UQCC	55245	broad.mit.edu	37	20	33999771	33999771	+	Translation_Start_Site	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:33999771C>A	uc002xcd.2	-	1	63	c.-4G>T	c.(-6--2)GAGGA>GATGA		UQCC_uc010zuz.1_Translation_Start_Site|UQCC_uc010zva.1_Translation_Start_Site|UQCC_uc002xce.2_Translation_Start_Site|UQCC_uc002xcg.2_Translation_Start_Site|UQCC_uc010gfb.2_Translation_Start_Site|UQCC_uc010zvb.1_Translation_Start_Site|UQCC_uc002xcf.2_Translation_Start_Site|GDF5_uc010gfc.1_Intron|UQCC_uc010gfd.1_Translation_Start_Site	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform							cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CGCCATGTTCCTCAATAACCA	0.567			NA											38	104					1.00001e-27	1.73904e-27	0.009718	1	0
C20orf117	140710	broad.mit.edu	37	20	35444016	35444016	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:35444016T>G	uc002xgd.1	-	5	1442	c.1115A>C	c.(1114-1116)CAG>CCG	p.Q372P	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	372											0		Myeloproliferative disorder(115;0.00874)				CCGCGTACTCTGGCAGGAGGC	0.662			NA											3	14					0	0	0.004672	0	0
SLC12A5	57468	broad.mit.edu	37	20	44684841	44684841	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:44684841C>T	uc010zxl.1	+	22	2985	c.2909C>T	c.(2908-2910)GCC>GTC	p.A970V	SLC12A5_uc002xrb.2_Missense_Mutation_p.A947V	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	970	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAGAATCCAGCCAACACGCGG	0.582			NA											15	24					0	0	0.003163	0	0
KCNB1	3745	broad.mit.edu	37	20	47989700	47989700	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:47989700G>T	uc002xur.1	-	2	2561	c.2397C>A	c.(2395-2397)AGC>AGA	p.S799R	KCNB1_uc002xus.1_Missense_Mutation_p.S799R	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	799	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GTAAAGGGGAGCTTTCAAAGT	0.522			NA											103	245					2.32112e-61	4.51628e-61	0.00361	1	0
B4GALT5	9334	broad.mit.edu	37	20	48263586	48263586	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:48263586T>A	uc002xuu.3	-	3	474	c.280A>T	c.(280-282)ACC>TCC	p.T94S		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	94	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			TGCAGGAAGGTTTCACTGTGG	0.443			NA											31	157					0	0	0.012213	0	0
ADNP	23394	broad.mit.edu	37	20	49510039	49510039	+	Silent	SNP	C	C	T	rs139951165		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:49510039C>T	uc002xvt.1	-	5	1557	c.1212G>A	c.(1210-1212)TCG>TCA	p.S404S	ADNP_uc002xvu.1_Silent_p.S404S	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	404						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TTAACTGGCCCGATGAGAGAG	0.562			NA											8	119					0	0	0.00308	0	0
NFATC2	4773	broad.mit.edu	37	20	50139662	50139662	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:50139662G>T	uc002xwd.2	-	2	1338	c.1118C>A	c.(1117-1119)CCC>CAC	p.P373H	NFATC2_uc002xwc.2_Missense_Mutation_p.P373H|NFATC2_uc010zyv.1_Missense_Mutation_p.P154H|NFATC2_uc010zyw.1_Missense_Mutation_p.P154H|NFATC2_uc010zyx.1_Missense_Mutation_p.P353H|NFATC2_uc010zyy.1_Missense_Mutation_p.P154H|NFATC2_uc010zyz.1_Missense_Mutation_p.P154H|NFATC2_uc002xwe.2_Missense_Mutation_p.P353H	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	373					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGGCCAAGTGGGCGGAACCAG	0.577			NA											34	200					1.57351e-24	2.65663e-24	0.003755	1	0
CTCFL	140690	broad.mit.edu	37	20	56098871	56098871	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:56098871G>T	uc010gix.1	-	1	1053	c.391C>A	c.(391-393)CAG>AAG	p.Q131K	CTCFL_uc010giw.1_Missense_Mutation_p.Q131K|CTCFL_uc002xym.2_Missense_Mutation_p.Q131K|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Missense_Mutation_p.Q131K|CTCFL_uc010gjb.1_Missense_Mutation_p.Q131K|CTCFL_uc010gjc.1_Missense_Mutation_p.Q131K|CTCFL_uc010gjd.1_Missense_Mutation_p.Q131K|CTCFL_uc010gje.2_Missense_Mutation_p.Q131K|CTCFL_uc010gjf.2_Intron|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Missense_Mutation_p.Q131K|CTCFL_uc010gji.1_Intron|CTCFL_uc010gjj.1_Missense_Mutation_p.Q131K|CTCFL_uc010gjk.1_Missense_Mutation_p.Q131K|CTCFL_uc010gjl.1_Missense_Mutation_p.Q131K	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	131					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			ACACACTGCTGCAGGCTCTGC	0.592			NA											17	119					5.03518e-11	6.78264e-11	0.007413	1	0
ZNF831	128611	broad.mit.edu	37	20	57829372	57829372	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:57829372G>C	uc002yan.2	+	5	4608	c.4608G>C	c.(4606-4608)GAG>GAC	p.E1536D		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1536						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCACAGAAGAGGGCAGAGCAC	0.493			NA											11	12					0	0	0.008291	0	0
GTPBP5	26164	broad.mit.edu	37	20	60776117	60776117	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr20:60776117A>T	uc002yce.3	+	7	1243	c.1205A>T	c.(1204-1206)CAG>CTG	p.Q402L	GTPBP5_uc011aab.1_Missense_Mutation_p.Q174L|GTPBP5_uc011aac.1_Missense_Mutation_p.Q174L|GTPBP5_uc011aad.1_Missense_Mutation_p.Q174L|GTPBP5_uc011aae.1_Missense_Mutation_p.Q174L|GTPBP5_uc011aaf.1_Missense_Mutation_p.Q244L	NM_015666	NP_056481	Q9H4K7	GTPB5_HUMAN	GTP binding protein 5	402	Localized in the mitocondria.|Not localized in the mitocondria.				ribosome biogenesis	mitochondrion	GTP binding|GTPase activity|magnesium ion binding				0	Breast(26;3.52e-09)		BRCA - Breast invasive adenocarcinoma(19;2.5e-08)			CAGGGCCGCCAGCCGCTCAGG	0.632			NA											4	14					0	0	0.001168	0	0
NCAM2	4685	broad.mit.edu	37	21	22838976	22838976	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:22838976G>T	uc002yld.1	+	13	1953	c.1704G>T	c.(1702-1704)AGG>AGT	p.R568S	NCAM2_uc011acb.1_Missense_Mutation_p.R426S	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	568	Fibronectin type-III 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ATGAAATCAGGGTTGCAGCTG	0.279			NA											4	10					0.00909568	0.0095258	0.009096	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28306969	28306969	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:28306969C>A	uc002ymg.2	-	4	2234	c.1505G>T	c.(1504-1506)GGG>GTG	p.G502V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	502	Disintegrin.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GTACTCAGGCCCGAATGTCAG	0.592	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											4	22					0.00909568	0.0095258	0.009096	1	0
RNF160	26046	broad.mit.edu	37	21	30343757	30343757	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:30343757C>A	uc002ymr.2	-	7	971	c.958G>T	c.(958-960)GCT>TCT	p.A320S	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	274							ligase activity|zinc ion binding				0						TCAAAATAAGCTGAGCGAATC	0.318			NA											10	80					3.07112e-06	3.56325e-06	0.010729	1	0
TIAM1	7074	broad.mit.edu	37	21	32537342	32537342	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:32537342G>A	uc002yow.1	-	17	3400	c.2928C>T	c.(2926-2928)ACC>ACT	p.T976T	TIAM1_uc011adk.1_Silent_p.T976T|TIAM1_uc011adl.1_Silent_p.T916T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	976					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CCTCTGGAGCGGTCTCAGCAC	0.502			NA											5	34					0	0	0.000602	0	0
SIM2	6493	broad.mit.edu	37	21	38114105	38114105	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:38114105T>C	uc002yvr.2	+	8	994	c.938T>C	c.(937-939)GTG>GCG	p.V313A	SIM2_uc002yvq.2_Missense_Mutation_p.V313A	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	313	PAC.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						TACGCCACCGTGGTGCACAAC	0.522			NA											6	9					0	0	0.001984	0	0
TTC3	7267	broad.mit.edu	37	21	38459658	38459658	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:38459658G>T	uc002yvz.2	+	2	206	c.101G>T	c.(100-102)AGC>ATC	p.S34I	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Missense_Mutation_p.S34I|TTC3_uc002ywb.2_Missense_Mutation_p.S34I|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Missense_Mutation_p.S34I	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	34					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				GAATTTATGAGCAATGATTAT	0.398	Ovarian(38;194 1649 35661)		NA											53	163					2.27459e-33	4.11723e-33	0.00361	1	0
UBASH3A	53347	broad.mit.edu	37	21	43833217	43833217	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:43833217C>A	uc002zbe.2	+	4	475	c.439C>A	c.(439-441)CCT>ACT	p.P147T	UBASH3A_uc002zbf.2_Missense_Mutation_p.P147T|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.P147T	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	147						cytosol|nucleus				ovary(3)	3						CACGGCCGTGCCTCTGGCTCT	0.617			NA											23	87					6.44725e-10	8.38477e-10	0.002299	1	0
RRP1B	23076	broad.mit.edu	37	21	45106693	45106693	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:45106693A>G	uc002zdk.2	+	12	1132	c.1018A>G	c.(1018-1020)ATA>GTA	p.I340V	RRP1B_uc002zdl.2_5'UTR	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	340					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		AGGAAGCAGTATATCTCAACT	0.473			NA											25	35					0	0	0.003954	0	0
TRPM2	7226	broad.mit.edu	37	21	45815319	45815320	+	Nonsense_Mutation	DNP	CC	CC	AA	rs144976050	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:45815319_45815320CC>AA	uc002zet.1	+	13	2030_2031	c.1817_1818CC>AA	c.(1816-1818)TCC>TAA	p.S606*	TRPM2_uc002zeu.1_Nonsense_Mutation_p.S606*|TRPM2_uc002zew.1_Nonsense_Mutation_p.S606*|TRPM2_uc010gpt.1_Nonsense_Mutation_p.S606*|TRPM2_uc002zex.1_Nonsense_Mutation_p.S392*|TRPM2_uc002zey.1_Nonsense_Mutation_p.S119*	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	606	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGCCTCCGGTCCCTCTACAAGC	0.455			NA											12	80					0	0	0.004672	0	0
TRPM2	7226	broad.mit.edu	37	21	45819256	45819256	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr21:45819256A>T	uc002zet.1	+	15	2353	c.2140A>T	c.(2140-2142)AAG>TAG	p.K714*	TRPM2_uc002zeu.1_Nonsense_Mutation_p.K714*|TRPM2_uc002zew.1_Nonsense_Mutation_p.K714*|TRPM2_uc010gpt.1_Nonsense_Mutation_p.K714*|TRPM2_uc002zex.1_Nonsense_Mutation_p.K500*|TRPM2_uc002zey.1_Nonsense_Mutation_p.K227*	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	714	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCCTGGGGGAAGACCACCTG	0.622			NA											10	29					0	0	0.010729	0	0
POTEH	23784	broad.mit.edu	37	22	16287715	16287715	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:16287715G>T	uc010gqp.2	-	1	223	c.171C>A	c.(169-171)CTC>CTA	p.L57L	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	57										skin(1)	1						TCTTGCTCCTGAGTGTCTTCA	0.612			NA											71	491					3.17147e-52	6.12338e-52	0.00361	1	0
MICAL3	57553	broad.mit.edu	37	22	18301459	18301459	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:18301459A>C	uc002zng.3	-	26	4321	c.3968T>G	c.(3967-3969)CTG>CGG	p.L1323R	MICAL3_uc011agl.1_Missense_Mutation_p.L1239R	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1323	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CTCCTCCACCAGGTCGCTCCG	0.657			NA											22	65					0	0	0.00333	0	0
HIRA	7290	broad.mit.edu	37	22	19318997	19318997	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:19318997C>A	uc002zpf.1	-	25	3240	c.3020G>T	c.(3019-3021)TGT>TTT	p.C1007F	HIRA_uc011agx.1_Silent_p.V843V|HIRA_uc010grn.1_Missense_Mutation_p.C800F|HIRA_uc010gro.1_Missense_Mutation_p.C963F	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	1007	Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					CTGTTCCTGACACTCGGTGAA	0.622			NA											13	55					3.27435e-08	4.01561e-08	0.00245	1	0
MED15	51586	broad.mit.edu	37	22	20937232	20937232	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:20937232A>T	uc002zsp.2	+	11	1595	c.1515A>T	c.(1513-1515)TCA>TCT	p.S505S	MED15_uc002zsq.2_Silent_p.S465S|MED15_uc010gso.2_Silent_p.S448S|MED15_uc002zsr.2_Silent_p.S439S|MED15_uc011ahs.1_Silent_p.S439S|MED15_uc002zss.2_Silent_p.S384S|MED15_uc011ahu.1_Silent_p.S215S|MED15_uc002zst.2_Silent_p.S121S|MED15_uc002zsu.2_Silent_p.S110S	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	505	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			GTGTCCCCTCACCTGGACCTT	0.617			NA											20	36					0	0	0.010504	0	0
PRAME	23532	broad.mit.edu	37	22	22891032	22891032	+	Silent	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:22891032T>A	uc002zwf.2	-	5	1143	c.987A>T	c.(985-987)ATA>ATT	p.I329I	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Silent_p.I313I|PRAME_uc010gtr.2_Silent_p.I329I|PRAME_uc002zwg.2_Silent_p.I329I|PRAME_uc002zwh.2_Silent_p.I329I|PRAME_uc002zwi.2_Silent_p.I329I|PRAME_uc002zwj.2_Silent_p.I329I|PRAME_uc002zwk.2_Silent_p.I329I	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	329	LRR 1.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		GGCAGTTAGTTATTGAGAGGG	0.547	Melanoma(73;1707 1838 15168 27201)		NA											53	68					0	0	0.00361	0	0
CRYBB2	1415	broad.mit.edu	37	22	25627657	25627657	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:25627657C>A	uc003abp.1	+	6	584	c.536C>A	c.(535-537)GCC>GAC	p.A179D		NM_000496	NP_000487	P43320	CRBB2_HUMAN	crystallin, beta B2	179	Beta/gamma crystallin 'Greek key' 4.				response to stimulus|visual perception		structural constituent of eye lens				0						GACTTTGGGGCCCCTCACCCC	0.652			NA											39	63					2.26627e-22	3.76712e-22	0.007835	1	0
SF3A1	10291	broad.mit.edu	37	22	30738254	30738254	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:30738254T>C	uc003ahl.2	-	6	944	c.812A>G	c.(811-813)TAT>TGT	p.Y271C		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	271					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						GATCTGAGCATAGGCCACCCG	0.448			NA											15	27					0	0	0.003163	0	0
DEPDC5	9681	broad.mit.edu	37	22	32233048	32233048	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:32233048C>T	uc003als.2	+	26	2376	c.2234C>T	c.(2233-2235)CCC>CTC	p.P745L	DEPDC5_uc011als.1_Missense_Mutation_p.P676L|DEPDC5_uc011alu.1_Missense_Mutation_p.P754L|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.P745L|DEPDC5_uc003alu.2_Missense_Mutation_p.P194L|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.P75L|DEPDC5_uc003alw.2_Missense_Mutation_p.P43L|DEPDC5_uc011alx.1_Intron	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	745					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						GCGTGCCTCCCCCTTACCACC	0.572			NA											17	64					0	0	0.004007	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37462912	37462912	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:37462912C>A	uc003aqs.1	-	17	2345	c.2231G>T	c.(2230-2232)CGC>CTC	p.R744L	TMPRSS6_uc003aqt.1_Missense_Mutation_p.R757L	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	744	Peptidase S1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						ACACAGCATGCGTGGCGTCAC	0.617			NA											6	21					4.36969e-10	5.70256e-10	0.001855	1	0
ITPR1	3708	broad.mit.edu	37	3	4695532	4695532	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:4695532C>T	uc003bqa.2	+	12	1306	c.958C>T	c.(958-960)CCT>TCT	p.P320S	ITPR1_uc010hca.1_Intron|ITPR1_uc011asu.1_Missense_Mutation_p.P320S|ITPR1_uc010hcb.1_Intron	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	320	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCAGGTAGACCCTGACTTTGA	0.468			NA											9	11					0	0	0.006214	0	0
FGD5	152273	broad.mit.edu	37	3	14861826	14861826	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:14861826G>A	uc003bzc.2	+	1	1358	c.1248G>A	c.(1246-1248)GTG>GTA	p.V416V	FGD5_uc011avk.1_Silent_p.V416V	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	416					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						TGGTGGTCGTGCTGGAGGAGG	0.672			NA											9	38					0	0	0.008291	0	0
TOP2B	7155	broad.mit.edu	37	3	25665829	25665829	+	Silent	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:25665829G>C	uc011awn.1	-	20	2497	c.2454C>G	c.(2452-2454)GGC>GGG	p.G818G	TOP2B_uc003cdj.2_Silent_p.G813G	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	818					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						CAGCATCTTTGCCACCATGAA	0.363			NA											4	104					0	0	0.000602	0	0
USP4	7375	broad.mit.edu	37	3	49343230	49343230	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:49343230C>A	uc003cwq.2	-	9	1125	c.1046G>T	c.(1045-1047)GGG>GTG	p.G349V	USP4_uc003cwo.2_Missense_Mutation_p.G79V|USP4_uc003cwp.2_Missense_Mutation_p.G79V|USP4_uc003cwr.2_Missense_Mutation_p.G302V	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	349					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		TGCAATTTCCCCTTTCATCCC	0.458			NA											16	53					2.31682e-05	2.64328e-05	0.003163	1	0
SEMA3F	6405	broad.mit.edu	37	3	50225348	50225348	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:50225348G>A	uc003cyj.2	+	19	2356	c.2158G>A	c.(2158-2160)GCA>ACA	p.A720T	SEMA3F_uc003cyk.2_Missense_Mutation_p.A689T	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	720					axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		ACCCCCAGGCGCAGGCCCCCC	0.667			NA											4	8					0	0	0.001168	0	0
RAD54L2	23132	broad.mit.edu	37	3	51679122	51679122	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:51679122C>T	uc011bdt.1	+	16	2658	c.2533C>T	c.(2533-2535)CAG>TAG	p.Q845*	RAD54L2_uc003dbh.2_Nonsense_Mutation_p.Q434*|RAD54L2_uc011bdu.1_Nonsense_Mutation_p.Q539*|RAD54L2_uc003dbj.2_Nonsense_Mutation_p.Q171*	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	845	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CCATGATGCCCAGGCAGTATG	0.488			NA											21	48					0	0	0.010504	0	0
IQCF2	389123	broad.mit.edu	37	3	51897343	51897343	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:51897343C>T	uc003dbt.1	+	3	490	c.452C>T	c.(451-453)ACA>ATA	p.T151I	IQCF1_uc003dbq.3_Intron|IQCF2_uc003dbu.1_RNA	NM_203424	NP_982248	Q8IXL9	IQCF2_HUMAN	IQ motif containing F2	151											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TGTGTGGTCACAGCCACTCAC	0.547			NA											30	85					0	0	0.003755	0	0
RFT1	91869	broad.mit.edu	37	3	53156537	53156537	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:53156537G>T	uc003dgj.2	-	4	363	c.309C>A	c.(307-309)ATC>ATA	p.I103I	RFT1_uc003dgk.2_Silent_p.I64I	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	103	Helical; (Potential).				carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		GCTGCAACCAGATCCAGCCCA	0.413			NA											19	26					2.39187e-15	3.50264e-15	0.008871	1	0
CACNA2D3	55799	broad.mit.edu	37	3	54786654	54786654	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:54786654G>T	uc003dhf.2	+	12	1244	c.1196G>T	c.(1195-1197)CGA>CTA	p.R399L	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.R305L|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Missense_Mutation_p.R133L	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	399	Extracellular (Potential).|VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CTCATTGGACGAGAGGCTGCG	0.512			NA											11	18					2.80697e-09	3.5764e-09	0.010729	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64672544	64672544	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:64672544C>T	uc003dmg.2	-	2	248	c.216G>A	c.(214-216)ACG>ACA	p.T72T	ADAMTS9_uc011bfo.1_Silent_p.T72T|ADAMTS9_uc003dmh.1_5'UTR|ADAMTS9_uc003dmk.1_Silent_p.T72T|uc003dml.2_Intron	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	72					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGCTCCGTCGCGTTCTTTTGA	0.468			NA											10	23					0	0	0.008291	0	0
EIF4E3	317649	broad.mit.edu	37	3	71748851	71748851	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:71748851C>A	uc003dov.3	-	3	266	c.258G>T	c.(256-258)TGG>TGT	p.W86C	EIF4E3_uc011bgc.1_5'UTR|EIF4E3_uc003dox.2_5'UTR|EIF4E3_uc011bgd.1_5'UTR|EIF4E3_uc010hoc.2_5'UTR	NM_001134651	NP_001128123	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E	86					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)		TGTATACACTCCAAAATATCT	0.318			NA											22	67					8.10497e-08	9.89148e-08	0.010504	1	0
HTR1F	3355	broad.mit.edu	37	3	88040284	88040284	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:88040284G>A	uc003dqr.2	+	2	543	c.385G>A	c.(385-387)GTT>ATT	p.V129I		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	129	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	CACAGATGCTGTTGAGTATGC	0.433			NA											6	30					0	0	0.001168	0	0
IMPG2	50939	broad.mit.edu	37	3	100963380	100963380	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:100963380C>T	uc003duq.1	-	13	1998	c.1795G>A	c.(1795-1797)GGT>AGT	p.G599S	IMPG2_uc011bhe.1_Missense_Mutation_p.G462S	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	599	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CCTAAACCACCGTCAAATATT	0.468			NA											28	121					0	0	0.012213	0	0
ZPLD1	131368	broad.mit.edu	37	3	102157407	102157407	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:102157407T>A	uc003dvs.1	+	9	958	c.76T>A	c.(76-78)TGT>AGT	p.C26S	ZPLD1_uc003dvt.1_Missense_Mutation_p.C42S|ZPLD1_uc011bhg.1_Missense_Mutation_p.C26S	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	26	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						CGGCTACAACTGTGATGCCAA	0.408			NA											14	27					0	0	0.001855	0	0
MORC1	27136	broad.mit.edu	37	3	108698419	108698419	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:108698419G>T	uc003dxl.2	-	24	2507	c.2420C>A	c.(2419-2421)GCG>GAG	p.A807E	MORC1_uc011bhn.1_Missense_Mutation_p.A786E	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	807					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTGAGAAGACGCTGGCGAAGA	0.413			NA											30	62					3.65163e-15	5.27769e-15	0.00632	1	0
CCDC80	151887	broad.mit.edu	37	3	112358661	112358661	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:112358661C>A	uc003dzf.2	-	2	310	c.92G>T	c.(91-93)GGC>GTC	p.G31V	CCDC80_uc011bhv.1_Missense_Mutation_p.G31V|CCDC80_uc003dzg.2_Missense_Mutation_p.G31V|CCDC80_uc003dzh.1_Missense_Mutation_p.G31V	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	31										ovary(2)	2						TCCGTGGCTGCCTCTAATAGT	0.552			NA											17	44					5.35267e-07	6.39771e-07	0.007413	1	0
WDR52	55779	broad.mit.edu	37	3	113084979	113084979	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:113084979C>A	uc003eae.1	-	19	2668	c.2622G>T	c.(2620-2622)GTG>GTT	p.V874V	WDR52_uc003ead.1_Silent_p.V55V	NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	874	WD 9.									central_nervous_system(1)	1						CTCCAGCAGTCACCAAGAAAC	0.373			NA											18	69					1.56452e-12	2.16959e-12	0.007413	1	0
KIAA1407	57577	broad.mit.edu	37	3	113724429	113724429	+	Silent	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:113724429T>A	uc003eax.2	-	10	1941	c.1794A>T	c.(1792-1794)GCA>GCT	p.A598A	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Silent_p.A576A|KIAA1407_uc011bip.1_Silent_p.A585A	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	598										ovary(2)	2						CTTCTGTGACTGCTAAGGCAT	0.493			NA											60	89					0	0	0.00361	0	0
DRD3	1814	broad.mit.edu	37	3	113890579	113890579	+	Silent	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:113890579T>A	uc003ebd.2	-	3	684	c.261A>T	c.(259-261)GTA>GTT	p.V87V	DRD3_uc010hqn.1_Silent_p.V87V|DRD3_uc003ebb.1_Silent_p.V87V|DRD3_uc003ebc.1_Silent_p.V87V	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	87	Helical; Name=2.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CCTCCAGGTATACCACCCAGG	0.547			NA											26	71					0	0	0.00632	0	0
C3orf15	89876	broad.mit.edu	37	3	119462963	119462963	+	Missense_Mutation	SNP	C	C	T	rs139653997		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:119462963C>T	uc003ede.3	+	14	1899	c.1822C>T	c.(1822-1824)CGG>TGG	p.R608W	C3orf15_uc010hqz.2_Missense_Mutation_p.R546W|C3orf15_uc011bjd.1_Missense_Mutation_p.R482W|C3orf15_uc011bje.1_Missense_Mutation_p.R588W	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	444						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GCGCCAGCGGCGGGTACGAGA	0.587			NA											18	45					0	0	0.008871	0	0
PARP14	54625	broad.mit.edu	37	3	122446791	122446791	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:122446791G>T	uc003efq.3	+	16	5133	c.5074G>T	c.(5074-5076)GTC>TTC	p.V1692F	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.V1409F	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1692	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CGTGCCACACGTCAATCGAAA	0.498			NA											12	21					0.00010058	0.000112536	0.001368	1	0
CCDC14	64770	broad.mit.edu	37	3	123634422	123634422	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:123634422G>T	uc011bjx.1	-	13	2157	c.2066C>A	c.(2065-2067)TCC>TAC	p.S689Y	CCDC14_uc003egv.3_Missense_Mutation_p.S330Y|CCDC14_uc003egx.3_Missense_Mutation_p.S489Y|CCDC14_uc010hrt.2_Missense_Mutation_p.S648Y|CCDC14_uc003egy.3_Missense_Mutation_p.S489Y|CCDC14_uc003egz.2_Intron	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	689				S -> P (in Ref. 2; BAH11968).		centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		GCTCATTATGGAAGTGTGAGC	0.388			NA											32	72					7.72975e-29	1.35676e-28	0.002836	1	0
PLXND1	23129	broad.mit.edu	37	3	129293305	129293305	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:129293305G>T	uc003emx.2	-	12	2659	c.2559C>A	c.(2557-2559)AGC>AGA	p.S853R		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	853	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AACAGTCGGGGCTGCCCATGG	0.672	Ovarian(97;366 1484 3738 22084 39045)		NA											9	18					0.000442599	0.00048512	0.006214	1	0
CLSTN2	64084	broad.mit.edu	37	3	140251280	140251280	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:140251280C>A	uc003etn.2	+	9	1649	c.1459C>A	c.(1459-1461)CAT>AAT	p.H487N	CLSTN2_uc003etm.2_Missense_Mutation_p.H487N	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	487	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTGGCCCATTCATCCATCTCA	0.458	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			32	68					2.42023e-17	3.66687e-17	0.003271	1	0
CLSTN2	64084	broad.mit.edu	37	3	140277558	140277558	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:140277558C>A	uc003etn.2	+	12	2090	c.1900C>A	c.(1900-1902)CGG>AGG	p.R634R		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	634	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CATCGAGCCCCGGATCACCCT	0.557	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			19	59					1.2644e-06	1.49231e-06	0.010504	1	0
CHST2	9435	broad.mit.edu	37	3	142840944	142840944	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:142840944T>A	uc003evm.2	+	2	2175	c.1286T>A	c.(1285-1287)GTG>GAG	p.V429E		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	429	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						GAGGACCTGGTGGGAGACCCC	0.587			NA											19	21					0	0	0.010504	0	0
GPR149	344758	broad.mit.edu	37	3	154055976	154055976	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:154055976G>A	uc003faa.2	-	4	1808	c.1708C>T	c.(1708-1710)CTT>TTT	p.L570F		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	570	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TAGGTAGAAAGAGATAGGGTT	0.468			NA											99	128					0	0	0.00361	0	0
GMPS	8833	broad.mit.edu	37	3	155632279	155632279	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:155632279C>A	uc003faq.2	+	8	1293	c.958C>A	c.(958-960)CGG>AGG	p.R320R	GMPS_uc011bom.1_Silent_p.R221R	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	320					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TAGAACCCCACGGAAAAGAAT	0.358	Ovarian(153;896 1876 4149 15499 28134)		NA	T	MLL	AML								31	68					2.47511e-08	3.06035e-08	0.008361	1	0
PPM1L	151742	broad.mit.edu	37	3	160783208	160783208	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:160783208G>T	uc003fdr.2	+	3	693	c.592G>T	c.(592-594)GCT>TCT	p.A198S	PPM1L_uc003fds.2_Missense_Mutation_p.A19S|PPM1L_uc003fdt.2_Missense_Mutation_p.A71S|PPM1L_uc010hwf.2_RNA	NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	198	Cytoplasmic (Potential).|PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			GTGTTTGATTGCTCTGCTATC	0.488	Pancreas(86;250 1994 13715 43211)		NA											24	72					7.92952e-12	1.08365e-11	0.003954	1	0
SLITRK3	22865	broad.mit.edu	37	3	164906717	164906717	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:164906717C>A	uc003fej.3	-	2	2346	c.1902G>T	c.(1900-1902)GGG>GGT	p.G634G	SLITRK3_uc003fek.2_Silent_p.G634G	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	634	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TGGTTGGTGCCCCAATAAGGT	0.527			NA								HNSCC(40;0.11)			6	12					0.00116845	0.00125871	0.001168	1	0
SAMD7	344658	broad.mit.edu	37	3	169637321	169637322	+	Missense_Mutation	DNP	AG	AG	TT			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:169637321_169637322AG>TT	uc003fgd.2	+	3	302_303	c.35_36AG>TT	c.(34-36)CAG>CTT	p.Q12L	SAMD7_uc003fge.2_Missense_Mutation_p.Q12L|SAMD7_uc011bpo.1_5'UTR	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	12										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			CCAACAGGGCAGCAGACAATCC	0.431			NA											30	51					0	0	0.004672	0	0
NLGN1	22871	broad.mit.edu	37	3	173322536	173322536	+	Missense_Mutation	SNP	G	G	T	rs79808130		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:173322536G>T	uc003fio.1	+	3	571	c.148G>T	c.(148-150)GAT>TAT	p.D50Y	NLGN1_uc010hww.1_Missense_Mutation_p.D50Y|NLGN1_uc003fip.1_Missense_Mutation_p.D50Y	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	50	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			AAAATTGGATGATGTGGACCC	0.458			NA											40	72					3.09479e-21	5.0441e-21	0.006999	1	0
MCF2L2	23101	broad.mit.edu	37	3	182947468	182947468	+	Nonsense_Mutation	SNP	G	G	T	rs149684646	by1000genomes	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:182947468G>T	uc003fli.1	-	17	2121	c.2031C>A	c.(2029-2031)TAC>TAA	p.Y677*	MCF2L2_uc003flj.1_Nonsense_Mutation_p.Y677*|MCF2L2_uc011bqr.1_RNA	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	677	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGTGAAATTCGTAAAGTTCTC	0.333			NA											41	71					1.22674e-20	1.98227e-20	0.00874	1	0
EPHB3	2049	broad.mit.edu	37	3	184290644	184290644	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:184290644G>T	uc003foz.2	+	3	973	c.536G>T	c.(535-537)CGC>CTC	p.R179L		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	179	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			ACCAAGGTGCGCAGCTTTGGG	0.602			NA											13	21					4.36969e-10	5.70256e-10	0.001855	1	0
LRRC15	131578	broad.mit.edu	37	3	194080235	194080236	+	Missense_Mutation	DNP	TC	TC	AT			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:194080235_194080236TC>AT	uc003ftu.2	-	2	1623_1624	c.1537_1538GA>AT	c.(1537-1539)GAA>ATA	p.E513I	LRRC15_uc003ftt.2_Missense_Mutation_p.E519I	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	513	Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		AGTGTAGTCTTCCACAGGGCTG	0.554			NA											21	38					0	0	0.004672	0	0
TFRC	7037	broad.mit.edu	37	3	195794416	195794416	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:195794416G>C	uc003fvz.3	-	9	1296	c.1013C>G	c.(1012-1014)TCC>TGC	p.S338C	TFRC_uc003fwa.3_Missense_Mutation_p.S338C|TFRC_uc010hzy.2_Missense_Mutation_p.S257C|TFRC_uc011btr.1_Missense_Mutation_p.S56C	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	338	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AGCAGCTCTGGAGATTGTCTG	0.428			NA	T	BCL6	NHL								14	56					0	0	0.004007	0	0
ABCA11P	79963	broad.mit.edu	37	4	420484	420484	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:420484T>C	uc003gae.2	-	5	957	c.422A>G	c.(421-423)AAA>AGA	p.K141R	ABCA11P_uc003gac.2_Missense_Mutation_p.K90R|ABCA11P_uc003gad.2_RNA|ABCA11P_uc011buv.1_3'UTR|ABCA11P_uc010ibd.1_Missense_Mutation_p.K141R					RecName: Full=Putative ATP-binding cassette sub-family A member 11;												0						AACTTCACTTTTTAACACAAA	0.393			NA											24	48					0	0	0.00278	0	0
RNF212	285498	broad.mit.edu	37	4	1066813	1066813	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:1066813G>A	uc003gcj.2	-	10	1073	c.743C>T	c.(742-744)ACC>ATC	p.T248I	RNF212_uc003gch.2_Intron|RNF212_uc003gci.2_Silent_p.H230H|RNF212_uc010ibp.2_RNA|RNF212_uc010ibq.2_3'UTR	NM_001131034	NP_001124506	Q495C1	RN212_HUMAN	ring finger protein 212 isoform a	248							zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (64;0.151)		TTTAGAGTTGGTGAGTTCCCC	0.527			NA									OREG0016028	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	38					0	0	0.001368	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401268	11401268	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:11401268G>A	uc003gmq.2	-	2	685	c.362C>T	c.(361-363)CCC>CTC	p.P121L		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	121						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						GAAATACGCGGGGGTCTTCTC	0.612			NA											22	58					0	0	0.012319	0	0
LDB2	9079	broad.mit.edu	37	4	16597466	16597466	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:16597466T>C	uc003goz.2	-	3	584	c.268A>G	c.(268-270)AGC>GGC	p.S90G	LDB2_uc003gpa.2_Missense_Mutation_p.S90G|LDB2_uc003gpb.2_Missense_Mutation_p.S90G|LDB2_uc011bxh.1_Missense_Mutation_p.S90G|LDB2_uc010iee.2_Missense_Mutation_p.S90G|LDB2_uc003goy.2_5'UTR|LDB2_uc011bxi.1_5'UTR	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	90							LIM domain binding|transcription cofactor activity				0						AACACAGTGCTAAAGTAACGG	0.498			NA											4	37					0	0	0.000602	0	0
BEND4	389206	broad.mit.edu	37	4	42145907	42145907	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:42145907T>A	uc003gwn.2	-	3	1172	c.592A>T	c.(592-594)ATT>TTT	p.I198F	BEND4_uc003gwm.2_Missense_Mutation_p.I198F|BEND4_uc011byy.1_Missense_Mutation_p.I198F	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	198											0						ACGCAAGAAATCATGGACTGA	0.473			NA											9	13					0	0	0.006214	0	0
EPHA5	2044	broad.mit.edu	37	4	66535311	66535311	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:66535311G>T	uc003hcy.2	-	1	343	c.150C>A	c.(148-150)CTC>CTA	p.L50L	EPHA5_uc003hcx.2_5'Flank|EPHA5_uc003hcz.2_Silent_p.L50L|EPHA5_uc011cah.1_Silent_p.L50L|EPHA5_uc011cai.1_Silent_p.L50L|EPHA5_uc003hda.2_Silent_p.L50L|uc003hdb.2_5'Flank	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	50	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GGAGGGTCCGGAGTGCGGCGC	0.726			NA								TSP Lung(17;0.13)			15	16					4.63292e-17	7.0052e-17	0.008871	1	0
UBA6	55236	broad.mit.edu	37	4	68562390	68562390	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:68562390G>C	uc003hdg.3	-	2	159	c.107C>G	c.(106-108)TCT>TGT	p.S36C	UBA6_uc003hdi.2_Missense_Mutation_p.S36C|UBA6_uc003hdj.2_Missense_Mutation_p.S36C	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	36					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						GATTTCCACAGATGCTGTTGA	0.284			NA											19	37					0	0	0.010504	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68938049	68938049	+	Missense_Mutation	SNP	C	C	G	rs150716612	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:68938049C>G	uc003hdt.1	-	5	555	c.506G>C	c.(505-507)AGA>ACA	p.R169T	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	169	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ACGTGTGAGTCTAAATGATGG	0.284			NA											28	17					0	0	0.009535	0	0
UGT2B15	7366	broad.mit.edu	37	4	69513061	69513061	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:69513061C>T	uc011cal.1	-	6	1392	c.1354G>A	c.(1354-1356)GAC>AAC	p.D452N		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	452					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						ATTGGTTGGTCATGATGAATT	0.388			NA											33	114					0	0	0.003271	0	0
IGJ	3512	broad.mit.edu	37	4	71532144	71532144	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:71532144C>G	uc003hfn.3	-	1	205	c.64G>C	c.(64-66)GCC>CCC	p.A22P	IGJ_uc010ihz.2_Missense_Mutation_p.G22R	NM_144646	NP_653247	P01591	IGJ_HUMAN	immunoglobulin J chain	22					immune response	extracellular region	antigen binding				0			Lung(101;0.235)			TATCACATACCTTTCACATGA	0.363			NA											23	36					0	0	0.004656	0	0
AFP	174	broad.mit.edu	37	4	74313357	74313357	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:74313357A>G	uc003hgz.1	+	8	1069	c.1022A>G	c.(1021-1023)CAA>CGA	p.Q341R	AFP_uc003hha.1_Missense_Mutation_p.Q341R|AFP_uc011cbg.1_Missense_Mutation_p.Q115R	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	341	Albumin 2.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GATTTTAACCAATTTTCTTCA	0.353			NA							Alpha-Fetoprotein_Hereditary_Persistence_of				13	23					0	0	0.00499	0	0
WDFY3	23001	broad.mit.edu	37	4	85724621	85724621	+	Splice_Site	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:85724621C>A	uc003hpd.2	-	16	2838	c.2430_splice	c.e16-1	p.R810_splice		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATATGCATGCCTATAAAAAAA	0.368			NA											20	35					3.62473e-10	4.74682e-10	0.012319	1	0
UNC5C	8633	broad.mit.edu	37	4	96140382	96140382	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:96140382G>T	uc003htp.1	-	9	1537	c.1383C>A	c.(1381-1383)GAC>GAA	p.D461E	UNC5C_uc010ilc.1_Missense_Mutation_p.D480E|UNC5C_uc003htq.2_Missense_Mutation_p.D480E	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	461	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTGGGATTTTGTCTGAGACGT	0.512			NA											76	206					2.02726e-29	3.5834e-29	0.00361	1	0
NHEDC1	150159	broad.mit.edu	37	4	103911057	103911057	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:103911057T>A	uc003hww.2	-	3	233	c.111A>T	c.(109-111)AAA>AAT	p.K37N	NHEDC1_uc003hwu.2_Missense_Mutation_p.K37N|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	37						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		ATAAGACAGTTTTAGTTTCTT	0.299			NA											6	23					0	0	0.001984	0	0
ARSJ	79642	broad.mit.edu	37	4	114823441	114823441	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:114823441T>A	uc003ibq.1	-	2	2677	c.1789A>T	c.(1789-1791)ACT>TCT	p.T597S	ARSJ_uc010imu.1_Intron	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	597				STCHSGVTCG -> KPANLAR (in Ref. 2).		extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TATCCACAAGTAACACCTGAA	0.244			NA											9	92					0	0	0.004482	0	0
SEC24D	9871	broad.mit.edu	37	4	119686060	119686060	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:119686060T>C	uc003ici.3	-	10	1465	c.1193A>G	c.(1192-1194)TAT>TGT	p.Y398C	SEC24D_uc003ich.3_RNA|SEC24D_uc003icj.3_Missense_Mutation_p.Y399C|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	398					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						ATGTTGGAAATAGAATGGTGG	0.318			NA											20	104					0	0	0.007413	0	0
TRPC3	7222	broad.mit.edu	37	4	122853835	122853835	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:122853835G>A	uc003ieg.2	-	2	652	c.578C>T	c.(577-579)GCC>GTC	p.A193V	TRPC3_uc010inr.2_Missense_Mutation_p.A120V|TRPC3_uc003ief.2_Missense_Mutation_p.A120V|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	108	Cytoplasmic (Potential).|ANK 3.				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						GTTGAGGATGGCCTCTACGAT	0.632			NA											23	11					0	0	0.012319	0	0
FAT4	79633	broad.mit.edu	37	4	126240058	126240058	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:126240058C>G	uc003ifj.3	+	1	2492	c.2492C>G	c.(2491-2493)ACT>AGT	p.T831S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	831	Extracellular (Potential).|Cadherin 8.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TATCTCATTACTACTGGGGAT	0.443			NA											5	171					0	0	0.000602	0	0
LARP1B	55132	broad.mit.edu	37	4	129012285	129012285	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:129012285G>T	uc003iga.2	+	6	619	c.488G>T	c.(487-489)AGA>ATA	p.R163I	LARP1B_uc003ifw.1_Missense_Mutation_p.R116I|LARP1B_uc003ifx.2_Missense_Mutation_p.R163I|LARP1B_uc003ify.2_Missense_Mutation_p.R163I|LARP1B_uc003ifz.1_Missense_Mutation_p.R163I	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	163	Arg-rich.						RNA binding				0						GGACGAGGCAGAGGAAATCCT	0.398			NA											18	167					1.67942e-08	2.09371e-08	0.006122	1	0
GAB1	2549	broad.mit.edu	37	4	144359508	144359508	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:144359508A>G	uc003ije.2	+	4	1309	c.950A>G	c.(949-951)TAT>TGT	p.Y317C	GAB1_uc003ijd.2_Missense_Mutation_p.Y317C|GAB1_uc011chq.1_Missense_Mutation_p.Y214C	NM_002039	NP_002030	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1 isoform b	317					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)					GGTAATACTTATCAGATTCCA	0.433			NA											16	113					0	0	0.003163	0	0
PRMT10	90826	broad.mit.edu	37	4	148589703	148589703	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:148589703T>C	uc003ilc.2	-	6	1082	c.940A>G	c.(940-942)AGA>GGA	p.R314G	PRMT10_uc003ild.2_Missense_Mutation_p.R201G	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	314						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						TGATGTCTTCTTATCTCTGCA	0.219			NA											21	34					0	0	0.004656	0	0
KIAA0922	23240	broad.mit.edu	37	4	154548817	154548817	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:154548817C>T	uc003inm.3	+	31	4234	c.4182C>T	c.(4180-4182)CCC>CCT	p.P1394P	KIAA0922_uc010ipp.2_Silent_p.P1395P|KIAA0922_uc010ipq.2_Silent_p.P1163P	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1394	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CTGCCGGGCCCACAGGTGTTG	0.517			NA											5	18					0	0	0.00308	0	0
TMEM144	55314	broad.mit.edu	37	4	159174649	159174649	+	Silent	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:159174649A>G	uc003ipx.2	+	13	1528	c.1008A>G	c.(1006-1008)GGA>GGG	p.G336G	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	336	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		TCTTGACTGGAGCCTTATGCA	0.393			NA											23	82					0	0	0.004656	0	0
FSTL5	56884	broad.mit.edu	37	4	162380415	162380415	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:162380415C>A	uc003iqh.2	-	14	2101	c.1665G>T	c.(1663-1665)CAG>CAT	p.Q555H	FSTL5_uc003iqi.2_Missense_Mutation_p.Q554H|FSTL5_uc010iqv.2_Missense_Mutation_p.Q545H	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	555						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GCACCCAGACCTGATCATGTG	0.363			NA											44	24					1.17673e-23	1.96906e-23	0.00361	1	0
ANP32C	23520	broad.mit.edu	37	4	165118707	165118707	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:165118707C>A	uc011cjk.1	-	1	157	c.157G>T	c.(157-159)GGC>TGC	p.G53C	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	53	LRR 1.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GAGGTGAGGCCTCCGTTGATT	0.443			NA											37	112					5.43694e-19	8.50957e-19	0.005524	1	0
ANXA10	11199	broad.mit.edu	37	4	169105768	169105768	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:169105768A>T	uc003irm.2	+	11	987	c.842A>T	c.(841-843)GAC>GTC	p.D281V	ANXA10_uc003irn.2_Missense_Mutation_p.D153V	NM_007193	NP_009124	Q9UJ72	ANX10_HUMAN	annexin A10	281	Annexin 4.						calcium ion binding|calcium-dependent phospholipid binding				0		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		AGTGAAATAGACCTGCTGACC	0.373			NA											59	74					0	0	0.00361	0	0
PALLD	23022	broad.mit.edu	37	4	169632955	169632955	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:169632955C>T	uc011cjx.1	+	10	2056	c.1845C>T	c.(1843-1845)CCC>CCT	p.P615P	PALLD_uc003iru.2_Silent_p.P615P|PALLD_uc003irv.2_Silent_p.P233P	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	615					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GAGTCCATCCCAGCCGTGGAG	0.512	Esophageal Squamous(109;1482 1532 18347 40239 51172)		NA							Pancreatic_Cancer_Familial_Clustering_of				15	39					0	0	0.00245	0	0
FRG1	2483	broad.mit.edu	37	4	190878613	190878613	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:190878613A>G	uc003izs.2	+	6	684	c.493A>G	c.(493-495)ATA>GTA	p.I165V		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	165					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		AGCAGGGGACATAGAAGCAAA	0.378			NA											3	43					0	0	0.001168	0	0
FBXL7	23194	broad.mit.edu	37	5	15928457	15928457	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:15928457T>A	uc003jfn.1	+	3	1067	c.586T>A	c.(586-588)TGC>AGC	p.C196S		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	196	LRR 2.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TGTCAGTGGCTGCAGGCGGCT	0.607			NA											8	19					0	0	0.00308	0	0
CDH9	1007	broad.mit.edu	37	5	26881466	26881466	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:26881466G>A	uc003jgs.1	-	12	2318	c.2149C>T	c.(2149-2151)CAT>TAT	p.H717Y	CDH9_uc011cnv.1_Missense_Mutation_p.H310Y	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	717	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AATCTTCGATGGATAAAATCT	0.413	Melanoma(8;187 585 15745 40864 52829)		NA											36	61					0	0	0.005524	0	0
SLC45A2	51151	broad.mit.edu	37	5	33947361	33947361	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:33947361C>A	uc003jid.2	-	6	1367	c.1275G>T	c.(1273-1275)CTG>CTT	p.L425L	SLC45A2_uc003jie.2_Silent_p.L425L	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	425	Extracellular (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGCACAGGACCAGGGTGGAGT	0.498	Ovarian(31;380 859 8490 22203 49048)		NA											71	109					7.59065e-32	1.35766e-31	0.00361	1	0
UGT3A2	167127	broad.mit.edu	37	5	36038112	36038112	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:36038112G>T	uc003jjz.1	-	6	1175	c.1082C>A	c.(1081-1083)CCA>CAA	p.P361Q	UGT3A2_uc011cos.1_Missense_Mutation_p.P327Q|UGT3A2_uc011cot.1_Missense_Mutation_p.P59Q	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	361	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACGGATGCTTGGGTGAGCTGT	0.507			NA											11	49					0.00010058	0.000112536	0.001368	1	0
HEATR7B2	133558	broad.mit.edu	37	5	41019043	41019043	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:41019043G>T	uc003jmj.3	-	25	3009	c.2519C>A	c.(2518-2520)CCA>CAA	p.P840Q	HEATR7B2_uc003jmi.3_Missense_Mutation_p.P395Q	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	840							binding			ovary(6)|central_nervous_system(2)	8						TTCCAGAGGTGGAAGGGGCAG	0.478			NA											11	30					7.03913e-09	8.8341e-09	0.001368	1	0
ERBB2IP	55914	broad.mit.edu	37	5	65346652	65346652	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:65346652C>T	uc003juk.1	+	20	2253	c.1945C>T	c.(1945-1947)CAC>TAC	p.H649Y	ERBB2IP_uc003jui.1_Missense_Mutation_p.H649Y|ERBB2IP_uc003juj.1_Missense_Mutation_p.H649Y|ERBB2IP_uc011cqx.1_Missense_Mutation_p.H649Y|ERBB2IP_uc011cqy.1_Missense_Mutation_p.H649Y|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.H645Y|ERBB2IP_uc003jul.1_Missense_Mutation_p.H645Y	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	649					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGAAGTTACACACAATAGCAA	0.333			NA											13	54					0	0	0.003163	0	0
FAM169A	26049	broad.mit.edu	37	5	74130289	74130289	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:74130289T>G	uc003kdm.2	-	5	495	c.452A>C	c.(451-453)AAA>ACA	p.K151T	FAM169A_uc010izm.2_Missense_Mutation_p.K151T|FAM169A_uc003kdl.2_Intron	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	151											0						GGCCTCTCCTTTCTTCCACAG	0.358			NA											21	59					0	0	0.00333	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834447	101834447	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:101834447C>A	uc003knn.2	-	1	274	c.102G>T	c.(100-102)AGG>AGT	p.R34S	SLCO6A1_uc003kno.2_Missense_Mutation_p.R34S|SLCO6A1_uc003knp.2_Missense_Mutation_p.R34S|SLCO6A1_uc003knq.2_Missense_Mutation_p.R34S	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	34	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TTCCCTTGGCCCTCCTGTCCT	0.607			NA											53	181					3.28156e-27	5.68049e-27	0.00361	1	0
NUDT12	83594	broad.mit.edu	37	5	102895744	102895744	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:102895744C>A	uc003koi.2	-	2	299	c.206G>T	c.(205-207)GGG>GTG	p.G69V	NUDT12_uc011cvb.1_Intron|NUDT12_uc010jbq.1_Missense_Mutation_p.G69V	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	69	ANK 2.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		AAATGTTTACCCTTTCTCAAG	0.363			NA											33	50					4.39465e-27	7.58984e-27	0.002836	1	0
FBN2	2201	broad.mit.edu	37	5	127666358	127666358	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:127666358G>A	uc003kuu.2	-	33	4691	c.4252C>T	c.(4252-4254)CAG>TAG	p.Q1418*	FBN2_uc003kuv.2_Nonsense_Mutation_p.Q1385*	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1418	EGF-like 23; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ATGCTACACTGGTGGGTTCCA	0.463			NA											23	28					0	0	0.005443	0	0
FBN2	2201	broad.mit.edu	37	5	127681204	127681204	+	Missense_Mutation	SNP	C	C	A	rs139620380	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:127681204C>A	uc003kuu.2	-	24	3501	c.3062G>T	c.(3061-3063)CGC>CTC	p.R1021L	FBN2_uc003kuv.2_Missense_Mutation_p.R988L	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1021	TB 5.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGCATCCATGCGGAACTTTCC	0.572			NA											23	49					3.08376e-08	3.80045e-08	0.00333	1	0
ISOC1	51015	broad.mit.edu	37	5	128440707	128440707	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:128440707A>T	uc003kva.2	+	2	386	c.368A>T	c.(367-369)CAG>CTG	p.Q123L		NM_016048	NP_057132	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	123						peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		TGTGATATGCAGGAAAGGTTC	0.388			NA											20	67					0	0	0.010504	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140752309	140752309	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:140752309A>C	uc003ljw.1	+	1	2348	c.2348A>C	c.(2347-2349)GAT>GCT	p.D783A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.D783A|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	783	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCTATGTGATGAAGCCTCT	0.378			NA											14	15					0	0	0.00245	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140762984	140762984	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:140762984G>T	uc003lka.1	+	1	518	c.518G>T	c.(517-519)AGC>ATC	p.S173I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.S173I	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	173	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACCAGCTCAGCCCCAATCGC	0.567			NA											8	26					0.00621372	0.00657153	0.006214	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140798154	140798154	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:140798154G>T	uc003lkn.1	+	1	873	c.728G>T	c.(727-729)AGC>ATC	p.S243I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.S243I|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	243	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGTGTTCAGCCAGGACGTG	0.567			NA											33	62					4.3181e-19	6.80236e-19	0.002836	1	0
PDGFRB	5159	broad.mit.edu	37	5	149515331	149515331	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:149515331C>A	uc003lro.2	-	3	620	c.151G>T	c.(151-153)GTT>TTT	p.V51F	PDGFRB_uc010jhd.2_5'UTR|PDGFRB_uc011dcg.1_Missense_Mutation_p.V51F	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	51	Extracellular (Potential).|Ig-like C2-type 1.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CAGGTCAGAACGAAGGTGCTG	0.607			NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								6	25					0.00116845	0.00125871	0.001168	1	0
GLRA1	2741	broad.mit.edu	37	5	151231087	151231087	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:151231087C>A	uc003lut.2	-	7	1063	c.776G>T	c.(775-777)AGC>ATC	p.S259I	GLRA1_uc003lur.2_Missense_Mutation_p.S259I|GLRA1_uc003lus.2_Missense_Mutation_p.S176I	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	259	Helical; (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AATGAGCAGGCTGGGAATATA	0.517			NA											25	57					3.65163e-15	5.27769e-15	0.00632	1	0
KIF4B	285643	broad.mit.edu	37	5	154395645	154395645	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:154395645A>T	uc010jih.1	+	1	2386	c.2226A>T	c.(2224-2226)CGA>CGT	p.R742R		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	742	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTGCAGCTCGAGTGAGGAATT	0.483			NA											10	31					0	0	0.008291	0	0
FAM71B	153745	broad.mit.edu	37	5	156589909	156589909	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:156589909C>A	uc003lwn.2	-	2	1467	c.1367G>T	c.(1366-1368)AGA>ATA	p.R456I		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	456	Bipartite nuclear localization signal (Potential).					nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCCCCCGCTCTCCTGCGGTG	0.478			NA											30	132					5.45727e-16	8.08922e-16	0.008361	1	0
ATP10B	23120	broad.mit.edu	37	5	160047932	160047932	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:160047932G>T	uc003lym.1	-	15	2685	c.1838C>A	c.(1837-1839)GCT>GAT	p.A613D	ATP10B_uc010jit.1_5'UTR|ATP10B_uc003lyn.2_Missense_Mutation_p.A171D	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	613	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CGTCCCCAGAGCCTTGCTTGA	0.468			NA											52	214					3.74213e-36	6.83937e-36	0.00361	1	0
DOCK2	1794	broad.mit.edu	37	5	169267762	169267762	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:169267762C>A	uc003maf.2	+	27	2785	c.2705C>A	c.(2704-2706)GCC>GAC	p.A902D	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.A394D	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	902					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTTTTACAGGCCTTCACCTAC	0.463			NA											9	23					4.68919e-08	5.7414e-08	0.008291	1	0
DOCK2	1794	broad.mit.edu	37	5	169469016	169469016	+	Splice_Site	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:169469016G>A	uc003maf.2	+	38	3837	c.3757_splice	c.e38-1	p.W1253_splice	DOCK2_uc011der.1_Splice_Site|DOCK2_uc010jjm.2_Splice_Site_p.W745_splice	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2						actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTCTTCACAGTGGTCGGATG	0.572			NA											13	24					0	0	0.00245	0	0
DOCK2	1794	broad.mit.edu	37	5	169474591	169474591	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:169474591C>A	uc003maf.2	+	40	4124	c.4044C>A	c.(4042-4044)TAC>TAA	p.Y1348*	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Nonsense_Mutation_p.Y840*	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1348	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGGATACTACGGCCAGGGAT	0.522			NA											24	39					5.35356e-11	7.19862e-11	0.00278	1	0
GABRP	2568	broad.mit.edu	37	5	170216248	170216248	+	Missense_Mutation	SNP	G	G	T	rs146765294	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:170216248G>T	uc003mau.2	+	3	367	c.169G>T	c.(169-171)GGT>TGT	p.G57C	GABRP_uc011dev.1_Missense_Mutation_p.G57C	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	57	Extracellular (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCCCAATTTTGGTGGTAGGTC	0.473			NA											13	12					1.61879e-10	2.14227e-10	0.001368	1	0
DRD1	1812	broad.mit.edu	37	5	174869090	174869090	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:174869090C>T	uc003mcz.2	-	2	1958	c.1013G>A	c.(1012-1014)CGG>CAG	p.R338Q		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	338	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	AAATGCCTTCCGAAAATCAGC	0.453			NA											22	37					0	0	0.002299	0	0
ZNF454	285676	broad.mit.edu	37	5	178391974	178391974	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:178391974G>T	uc003mjo.1	+	5	840	c.569G>T	c.(568-570)AGT>ATT	p.S190I	ZNF454_uc010jkz.1_Missense_Mutation_p.S190I	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	190	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TTCTCTAAGAGTTCAACTCTT	0.333			NA											7	47					2.0095e-06	2.34597e-06	0.001984	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178555076	178555076	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:178555076T>A	uc003mjw.2	-	17	2501	c.2501A>T	c.(2500-2502)TAC>TTC	p.Y834F		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	834	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ATGGATCATGTATTTGTACGT	0.577			NA											30	33					0	0	0.003271	0	0
RIPK1	8737	broad.mit.edu	37	6	3105766	3105766	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:3105766C>G	uc010jni.2	+	9	1289	c.1057C>G	c.(1057-1059)CCT>GCT	p.P353A	RIPK1_uc003muv.3_Missense_Mutation_p.P190A|RIPK1_uc003muw.3_Missense_Mutation_p.P288A|RIPK1_uc011dhs.1_Missense_Mutation_p.P307A|RIPK1_uc003mux.2_Missense_Mutation_p.P353A	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	353	Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TGGGATGGGTCCTGTGGAGGA	0.498			NA											6	299					0	0	0.001168	0	0
OR2W1	26692	broad.mit.edu	37	6	29012657	29012657	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:29012657A>G	uc003nlw.2	-	1	296	c.296T>C	c.(295-297)ATC>ACC	p.I99T		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ATAGAGTTGGATGATACAACC	0.433			NA											38	16					0	0	0.006999	0	0
OR2B3	442184	broad.mit.edu	37	6	29054921	29054921	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:29054921G>A	uc003nlx.2	-	1	170	c.105C>T	c.(103-105)TAC>TAT	p.Y35Y		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						TGGTGATTGTGTATGATATTA	0.408			NA											58	21					0	0	0.00361	0	0
TNXB	7148	broad.mit.edu	37	6	32011608	32011608	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:32011608G>A	uc003nzl.2	-	35	11644	c.11442C>T	c.(11440-11442)ATC>ATT	p.I3814I	TNXB_uc003nzg.1_Silent_p.I245I|TNXB_uc003nzh.1_Silent_p.I283I	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3861	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GAGCGCCTGGGATCAGCCCCT	0.627			NA											8	139					0	0	0.00308	0	0
TNXB	7148	broad.mit.edu	37	6	32024666	32024666	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:32024666T>A	uc003nzl.2	-	23	8042	c.7840A>T	c.(7840-7842)ACC>TCC	p.T2614S		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2674					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GCTTGGGTGGTCTCGGCTTCA	0.582			NA											65	18					0	0	0.00361	0	0
TAP2	6891	broad.mit.edu	37	6	32797760	32797760	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:32797760T>A	uc003occ.2	-	9	1773	c.1742A>T	c.(1741-1743)CAG>CTG	p.Q581L	TAP2_uc011dqf.1_Missense_Mutation_p.Q581L|TAP2_uc003ocb.1_Missense_Mutation_p.Q581L|TAP2_uc003ocd.2_Missense_Mutation_p.Q581L	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	581	ABC transporter.|Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GTGGGCAGCCTGGGCAGCCGC	0.488			NA											133	47					0	0	0.00361	0	0
COL19A1	1310	broad.mit.edu	37	6	70647991	70647991	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:70647991C>A	uc003pfc.1	+	9	1052	c.935C>A	c.(934-936)CCG>CAG	p.P312Q	COL19A1_uc010kam.1_Missense_Mutation_p.P208Q	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	312	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AAAGGAGAGCCGGTAAGAAAA	0.373			NA											14	11					0.000219431	0.000243346	0.00245	1	0
RIPPLY2	134701	broad.mit.edu	37	6	84563492	84563492	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:84563492G>T	uc003pke.2	+	2	325	c.174G>T	c.(172-174)GCG>GCT	p.A58A		NM_001009994	NP_001009994	Q5TAB7	RIPP2_HUMAN	ripply2 protein	58					somite rostral/caudal axis specification	nucleus					0						CCGCGGAGGCGGTGAGTGAGC	0.667			NA											7	7					3.09899e-07	3.72175e-07	0.004482	1	0
TBX18	9096	broad.mit.edu	37	6	85446500	85446500	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:85446500T>A	uc003pkl.1	-	8	1727	c.1727A>T	c.(1726-1728)CAC>CTC	p.H576L	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	576					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GCTAAGCAGGTGCACTCCTTC	0.502			NA											39	14					0	0	0.004878	0	0
MDN1	23195	broad.mit.edu	37	6	90468063	90468063	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:90468063C>A	uc003pnn.1	-	19	2729	c.2613G>T	c.(2611-2613)CTG>CTT	p.L871L	MDN1_uc003pno.1_Silent_p.L290L	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	871					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GATGCCGAACCAGTGGCTCTG	0.453			NA											12	1					6.40141e-05	7.24851e-05	0.010729	1	0
GRIK2	2898	broad.mit.edu	37	6	102074407	102074407	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:102074407T>A	uc003pqp.3	+	3	685	c.436T>A	c.(436-438)TAT>AAT	p.Y146N	GRIK2_uc003pqn.2_Missense_Mutation_p.Y146N|GRIK2_uc003pqo.3_Missense_Mutation_p.Y146N|GRIK2_uc010kcw.2_Missense_Mutation_p.Y146N	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	146	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AGATTCCTTCTATGTCAGTCT	0.498			NA											25	35					0	0	0.003954	0	0
LAMA2	3908	broad.mit.edu	37	6	129835715	129835715	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:129835715C>A	uc003qbn.2	+	63	9291	c.9186C>A	c.(9184-9186)GAC>GAA	p.D3062E	LAMA2_uc003qbo.2_Missense_Mutation_p.D3058E|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	3062	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ACACAAATGACCCTGTGTTTG	0.463			NA											11	37					1.08611e-07	1.32123e-07	0.010729	1	0
TMEM200A	114801	broad.mit.edu	37	6	130761637	130761637	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:130761637C>A	uc003qca.2	+	3	941	c.70C>A	c.(70-72)CAG>AAG	p.Q24K	TMEM200A_uc010kfh.2_Missense_Mutation_p.Q24K|TMEM200A_uc010kfi.2_Missense_Mutation_p.Q24K|TMEM200A_uc003qcb.2_Missense_Mutation_p.Q24K	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	24	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CAGATCACAGCAGCATGTCAA	0.537			NA											29	109					7.38237e-10	9.55141e-10	0.00632	1	0
SLC35D3	340146	broad.mit.edu	37	6	137245704	137245704	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:137245704C>T	uc003qhe.2	+	2	1286	c.1121C>T	c.(1120-1122)GCT>GTT	p.A374V		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	374					carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		CCGCTGGTGGCTGGGAGCTCT	0.587			NA											13	28					0	0	0.001855	0	0
GPR126	57211	broad.mit.edu	37	6	142725021	142725021	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:142725021G>C	uc010khc.2	+	14	2449	c.2038G>C	c.(2038-2040)GCT>CCT	p.A680P	GPR126_uc010khd.2_Missense_Mutation_p.A652P|GPR126_uc010khe.2_Missense_Mutation_p.A680P|GPR126_uc010khf.2_Missense_Mutation_p.A652P	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	680	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TCGGAACTTGGCTCTCAGCGT	0.368			NA											30	52					0	0	0.010818	0	0
SHPRH	257218	broad.mit.edu	37	6	146262953	146262953	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:146262953C>G	uc003qlf.2	-	10	2695	c.2296G>C	c.(2296-2298)GAT>CAT	p.D766H	SHPRH_uc003qld.2_Missense_Mutation_p.D766H|SHPRH_uc003qle.2_Missense_Mutation_p.D766H|SHPRH_uc003qlg.1_Missense_Mutation_p.D322H|SHPRH_uc003qlj.1_Missense_Mutation_p.D655H	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	766	Helicase ATP-binding; second part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		ATAACTATATCCTGTTCTGCC	0.388			NA											9	42					0	0	0.004482	0	0
IYD	389434	broad.mit.edu	37	6	150690185	150690185	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:150690185C>T	uc003qnu.1	+	1	158	c.18C>T	c.(16-18)CCC>CCT	p.P6P	IYD_uc003qnv.1_Silent_p.P6P|IYD_uc003qnw.1_RNA|IYD_uc003qnx.1_Silent_p.P6P|IYD_uc010kik.1_5'UTR	NM_203395	NP_981932	Q6PHW0	IYD1_HUMAN	iodotyrosine dehalogenase 1 isoform 2	6					cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				ovary(2)	2		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		TCCTGACTCCCATCTTGGTAG	0.502			NA											111	167					0	0	0.00361	0	0
PARK2	5071	broad.mit.edu	37	6	161771171	161771171	+	Missense_Mutation	SNP	C	C	A	rs137853056		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:161771171C>A	uc003qtx.3	-	12	1492	c.1358G>T	c.(1357-1359)TGG>TTG	p.W453L	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.W262L|PARK2_uc003qtw.3_3'UTR|PARK2_uc003qty.3_Missense_Mutation_p.W425L|PARK2_uc003qtz.3_Missense_Mutation_p.W304L|PARK2_uc011egf.1_Missense_Mutation_p.W127L	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	453					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GACGCGGTTCCACTCGCAGCC	0.637			NA											3	16					0.004672	0.00494798	0.004672	1	0
C6orf118	168090	broad.mit.edu	37	6	165715541	165715541	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:165715541G>T	uc003qum.3	-	2	306	c.270C>A	c.(268-270)CGC>CGA	p.R90R	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	90											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCTCAGAGGCGCGCTCCCCCT	0.657			NA											37	54					2.75727e-19	4.35268e-19	0.004878	1	0
T	6862	broad.mit.edu	37	6	166574359	166574359	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:166574359C>A	uc003quu.1	-	8	1493	c.1000G>T	c.(1000-1002)GTG>TTG	p.V334L	T_uc003qut.1_Missense_Mutation_p.V335L|T_uc003quv.1_Missense_Mutation_p.V276L	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	334					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TTGTGGCTCACGGGGAGCATG	0.542			NA							Chordoma_Familial_Clustering_of				46	59					1.61004e-24	2.71221e-24	0.00361	1	0
THSD7A	221981	broad.mit.edu	37	7	11676130	11676130	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:11676130G>T	uc003ssf.3	-	2	901	c.649C>A	c.(649-651)CGG>AGG	p.R217R		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	217	Extracellular (Potential).|TSP type-1 2.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGACGCGTCCGGTGCTGGAGC	0.617			NA								HNSCC(18;0.044)			7	31					0.00198382	0.00211889	0.001984	1	0
ITGB8	3696	broad.mit.edu	37	7	20441685	20441685	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:20441685G>T	uc003suu.2	+	10	2328	c.1623G>T	c.(1621-1623)GTG>GTT	p.V541V	ITGB8_uc011jyh.1_Silent_p.V406V	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	541	Cysteine-rich tandem repeats.|II.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						TTGGAAAAGTGTATGGAAAAT	0.398			NA											50	159					3.19069e-20	5.13373e-20	0.00361	1	0
DNAH11	8701	broad.mit.edu	37	7	21788210	21788210	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:21788210C>T	uc003svc.2	+	53	8575	c.8544C>T	c.(8542-8544)AGC>AGT	p.S2848S		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2848	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTCGCATCAGCCGGATCTTAC	0.498			NA							Kartagener_syndrome				7	40					0	0	0.004482	0	0
DDC	1644	broad.mit.edu	37	7	50607692	50607692	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:50607692T>A	uc003tpf.3	-	3	322	c.236A>T	c.(235-237)TAC>TTC	p.Y79F	DDC_uc010kza.2_Missense_Mutation_p.Y79F|DDC_uc003tpg.3_Missense_Mutation_p.Y79F	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	79	1.|2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	AGTGGGGAAGTAGGCGAAGAA	0.642			NA											41	19					0	0	0.013114	0	0
VOPP1	81552	broad.mit.edu	37	7	55565340	55565340	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:55565340G>A	uc003tqs.2	-	3	340	c.157C>T	c.(157-159)CGG>TGG	p.R53W	VOPP1_uc003tqq.2_Missense_Mutation_p.R44W|VOPP1_uc010kzh.2_Missense_Mutation_p.R50W|VOPP1_uc010kzi.2_Missense_Mutation_p.R36W|VOPP1_uc011kcr.1_5'UTR	NM_030796	NP_110423	Q96AW1	VOPP1_HUMAN	EGFR-coamplified and overexpressed protein	53	Extracellular (Potential).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity				0						GAGAGGGCCCGCACACAGCAC	0.627			NA											4	174					0	0	0.000602	0	0
ZNF107	51427	broad.mit.edu	37	7	64166746	64166746	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:64166746A>G	uc003ttd.2	+	7	850	c.64A>G	c.(64-66)ATA>GTA	p.I22V	ZNF107_uc003tte.2_Missense_Mutation_p.I22V	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AGAGCAGAACATAAAAGATTC	0.338			NA											24	58					0	0	0.009535	0	0
TYW1B	441250	broad.mit.edu	37	7	72281203	72281203	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:72281203C>A	uc011kej.1	-	4	445	c.286G>T	c.(286-288)GGC>TGC	p.G96C	TYW1B_uc011keh.1_Intron|TYW1B_uc011kek.1_Intron	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	96	Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GTTGGTAGGCCGTCAGTGTAT	0.418			NA											23	98					4.26978e-12	5.84571e-12	0.00333	1	0
PCLO	27445	broad.mit.edu	37	7	82579765	82579765	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:82579765C>A	uc003uhx.2	-	6	10428	c.10139G>T	c.(10138-10140)GGT>GTT	p.G3380V	PCLO_uc003uhv.2_Missense_Mutation_p.G3380V|PCLO_uc010lec.2_Missense_Mutation_p.G345V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3311					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGAGTAACACCATCAGACTG	0.438			NA											16	35					8.60227e-14	1.21987e-13	0.004007	1	0
PCLO	27445	broad.mit.edu	37	7	82582433	82582433	+	Silent	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:82582433A>G	uc003uhx.2	-	5	8125	c.7836T>C	c.(7834-7836)GAT>GAC	p.D2612D	PCLO_uc003uhv.2_Silent_p.D2612D|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2543					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAGAAACCAGATCTTTGGAGG	0.433			NA											74	96					0	0	0.00361	0	0
SEMA3D	223117	broad.mit.edu	37	7	84751060	84751060	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:84751060T>A	uc003uic.2	-	1	188	c.148A>T	c.(148-150)AAA>TAA	p.K50*	SEMA3D_uc010led.2_Nonsense_Mutation_p.K50*|SEMA3D_uc010lee.1_Nonsense_Mutation_p.K50*	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	50	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TATTTACCTTTGTAGGTTAGC	0.299	Ovarian(63;442 1191 17318 29975 31528)		NA											10	31					0	0	0.008291	0	0
ABCB1	5243	broad.mit.edu	37	7	87135292	87135292	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:87135292A>G	uc003uiz.1	-	28	3975	c.3557T>C	c.(3556-3558)ATA>ACA	p.I1186T	ABCB1_uc011khc.1_Missense_Mutation_p.I1122T	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1186	Cytoplasmic (Potential).|ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GGCACGAGCTATGGCAATGCG	0.403			NA											41	84					0	0	0.009718	0	0
DBF4	10926	broad.mit.edu	37	7	87536810	87536811	+	Missense_Mutation	DNP	CT	CT	GA			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:87536810_87536811CT>GA	uc003ujf.1	+	12	1861_1862	c.1357_1358CT>GA	c.(1357-1359)CTA>GAA	p.L453E	DBF4_uc003ujh.1_Missense_Mutation_p.L193E|DBF4_uc003ujg.1_Missense_Mutation_p.L229E|DBF4_uc011khf.1_Missense_Mutation_p.L220E	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	453					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				ACAGCTACCTCTACATAAAAAC	0.322			NA											17	27					0	0	0.004672	0	0
C7orf63	79846	broad.mit.edu	37	7	89900854	89900854	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:89900854A>T	uc010lep.2	+	7	798	c.547A>T	c.(547-549)AGT>TGT	p.S183C	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_5'UTR|C7orf63_uc011khj.1_Missense_Mutation_p.S165C|C7orf63_uc010leo.2_Missense_Mutation_p.S181C	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	183							binding			ovary(1)	1						CCAGCAAGCGAGTTCATCATA	0.323			NA											25	53					0	0	0.005443	0	0
COL1A2	1278	broad.mit.edu	37	7	94054961	94054961	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:94054961C>T	uc003ung.1	+	43	3292	c.2821C>T	c.(2821-2823)CAA>TAA	p.Q941*	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	941					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCGCGATGGTCAACCCGGACA	0.483			NA								HNSCC(75;0.22)			21	38					0	0	0.00278	0	0
PON3	5446	broad.mit.edu	37	7	94991730	94991730	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:94991730G>A	uc003unt.2	-	8	875	c.850C>T	c.(850-852)CAT>TAT	p.H284Y	PON1_uc011kih.1_Intron	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	284					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			GGATTAGGATGGCATCCTGCC	0.478			NA											10	24					0	0	0.001855	0	0
SHFM1	7979	broad.mit.edu	37	7	96318269	96318269	+	Silent	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:96318269T>C	uc003uoi.2	-	3	308	c.180A>G	c.(178-180)CTA>CTG	p.L60L	SHFM1_uc010lfn.1_Intron	NM_006304	NP_006295	P60896	DSS1_HUMAN	split hand/foot malformation type 1	60					proteolysis	proteasome complex	peptidase activity|protein binding				0	all_cancers(62;4.24e-09)|all_epithelial(64;5.59e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0353)|Lung NSC(181;0.0987)					CATGTTTCTCTAGTTCAGCTC	0.318			NA						Direct_reversal_of_damage|Homologous_recombination					14	47					0	0	0.004007	0	0
PILRB	29990	broad.mit.edu	37	7	99956677	99956677	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:99956677G>T	uc003uuk.2	+	16	2925	c.429G>T	c.(427-429)AAG>AAT	p.K143N	PILRB_uc003uul.2_Missense_Mutation_p.G74W|PILRB_uc003uum.1_RNA|PILRB_uc003uun.2_Missense_Mutation_p.K143N	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta	143	Extracellular (Potential).|Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGTCCATCAAGGGGACCAAAC	0.567			NA											20	29					1.33834e-09	1.71974e-09	0.007413	1	0
MUC17	140453	broad.mit.edu	37	7	100685329	100685329	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:100685329C>A	uc003uxp.1	+	3	10685	c.10632C>A	c.(10630-10632)TCC>TCA	p.S3544S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3544	Extracellular (Potential).|Ser-rich.|57.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGTTGACTCCAACACTTTTG	0.483			NA											108	253					6.25226e-48	1.1829e-47	0.00361	1	0
CUX1	1523	broad.mit.edu	37	7	101916724	101916724	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:101916724A>T	uc003uyt.2	+	15	1362	c.1343A>T	c.(1342-1344)GAC>GTC	p.D448V	CUX1_uc011kkn.1_Missense_Mutation_p.D409V|CUX1_uc003uyw.2_Missense_Mutation_p.D402V|CUX1_uc003uyv.2_Missense_Mutation_p.D432V|CUX1_uc003uyu.2_Missense_Mutation_p.D446V|CUX1_uc003uyz.2_5'Flank	NM_001913	NP_001904	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform b	305	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CTGGAGCAGGACCTGAGCATC	0.632			NA											12	9					0	0	0.010729	0	0
RELN	5649	broad.mit.edu	37	7	103151432	103151433	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:103151432_103151433GG>CT	uc003vca.2	-	51	8299_8300	c.8139_8140CC>AG	c.(8137-8142)TTCCAT>TTAGAT	p.2713_2714FH>LD	RELN_uc010liz.2_Missense_Mutation_p.2713_2714FH>LD	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2713_2714					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAATCATCATGGAATAGCCAGT	0.386	NSCLC(146;835 1944 15585 22231 52158)		NA											11	37					0	0	0.004672	0	0
CDHR3	222256	broad.mit.edu	37	7	105672970	105672970	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:105672970G>A	uc003vdl.3	+	19	2593	c.2485G>A	c.(2485-2487)GGG>AGG	p.G829R	CDHR3_uc003vdk.2_3'UTR|CDHR3_uc003vdm.3_Missense_Mutation_p.G816R|CDHR3_uc011klt.1_Missense_Mutation_p.G741R|CDHR3_uc003vdn.2_3'UTR	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	829	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						TGCTGGGGAAGGGATGGGGTC	0.552			NA											18	26					0	0	0.007413	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508039	106508039	+	Silent	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:106508039G>C	uc003vdv.3	+	2	118	c.33G>C	c.(31-33)GTG>GTC	p.V11V	PIK3CG_uc003vdu.2_Silent_p.V11V|PIK3CG_uc003vdw.2_Silent_p.V11V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	11					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						AGCCCGTGGTGCTGAGAGAGG	0.587			NA											25	46					0	0	0.005443	0	0
LAMB4	22798	broad.mit.edu	37	7	107674697	107674697	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:107674697G>T	uc010ljo.1	-	31	4858	c.4774C>A	c.(4774-4776)CAG>AAG	p.Q1592K	LAMB4_uc003vey.2_Missense_Mutation_p.Q1592K|LAMB4_uc010ljp.1_Missense_Mutation_p.Q561K	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1592	Potential.|Domain I.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GCAGTCAGCTGTGTAATGGTA	0.353			NA											53	105					6.9144e-35	1.26066e-34	0.00361	1	0
LRRN3	54674	broad.mit.edu	37	7	110763692	110763692	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:110763692G>A	uc003vft.3	+	4	1910	c.864G>A	c.(862-864)GAG>GAA	p.E288E	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.E288E|LRRN3_uc003vfs.3_Silent_p.E288E	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	288	Extracellular (Potential).|LRR 10.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ACTTAAAAGAGTTGGGGATAA	0.328			NA											14	78					0	0	0.004007	0	0
WNT16	51384	broad.mit.edu	37	7	120969762	120969762	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:120969762G>T	uc003vjw.2	+	2	494	c.237G>T	c.(235-237)CAG>CAT	p.Q79H	WNT16_uc003vjv.2_Missense_Mutation_p.Q69H|WNT16_uc010lkl.2_Translation_Start_Site	NM_057168	NP_476509	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family,	79					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			lung(2)|ovary(2)|large_intestine(1)	5	all_neural(327;0.117)					TGGGCATTCAGGAGTGCGGGA	0.652			NA											24	31					9.80776e-20	1.55807e-19	0.00632	1	0
TSPAN33	340348	broad.mit.edu	37	7	128801519	128801519	+	Splice_Site	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:128801519G>T	uc003vop.1	+	2	332	c.103_splice	c.e2-1	p.V35_splice		NM_178562	NP_848657	Q86UF1	TSN33_HUMAN	tetraspanin 33							integral to membrane				ovary(1)	1						TGTCTCCACAGGTGATTTCCA	0.552			NA											48	105					3.77171e-38	6.99532e-38	0.00361	1	0
DGKI	9162	broad.mit.edu	37	7	137341270	137341270	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:137341270C>A	uc003vtt.2	-	4	624	c.623G>T	c.(622-624)AGG>ATG	p.R208M	DGKI_uc003vtu.2_Translation_Start_Site	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	208	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						TGCACACTTCCTCCTGAGAGC	0.418			NA									OREG0018350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	85	121					2.88734e-31	5.13987e-31	0.00361	1	0
C7orf34	135927	broad.mit.edu	37	7	142637544	142637544	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:142637544C>A	uc003wca.2	+	2	355	c.314C>A	c.(313-315)ACG>AAG	p.T105K		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	80						extracellular region					0	Melanoma(164;0.059)					TCGTCCAAGACGGCAGCTGTT	0.532			NA											43	80					5.44703e-19	8.50957e-19	0.009718	1	0
SSPO	23145	broad.mit.edu	37	7	149484826	149484826	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:149484826C>G	uc010lpk.2	+	25	3648	c.3648C>G	c.(3646-3648)TGC>TGG	p.C1216W		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1216	VWFD 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCACATTATGCCACGCGGAGG	0.667			NA											2	3					0	0	0.004672	0	0
ZNF862	643641	broad.mit.edu	37	7	149561358	149561358	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:149561358C>T	uc010lpn.2	+	8	3687	c.3495C>T	c.(3493-3495)GCC>GCT	p.A1165A	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	1165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						GCCAGGAGGCCCCCGGGATGT	0.622			NA											5	10					0	0	0.001984	0	0
ZNF775	285971	broad.mit.edu	37	7	150094431	150094431	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:150094431A>C	uc003whf.1	+	3	987	c.862A>C	c.(862-864)AAG>CAG	p.K288Q		NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	288	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGAGTGTGGCAAGAGCTTCAC	0.478			NA											3	26					0	0	0.004672	0	0
TMEM176B	28959	broad.mit.edu	37	7	150488658	150488658	+	Silent	SNP	C	C	A	rs146845592	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:150488658C>A	uc003wht.3	-	7	940	c.774G>T	c.(772-774)TCG>TCT	p.S258S	TMEM176B_uc003whu.3_Silent_p.S258S|TMEM176B_uc003whv.3_Silent_p.S221S|TMEM176B_uc003whw.3_Silent_p.S258S	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	258					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCTAGAGGGCGAAGGGGGCA	0.567			NA											21	30					7.41877e-09	9.29507e-09	0.012319	1	0
ABP1	26	broad.mit.edu	37	7	150553761	150553761	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:150553761C>G	uc003why.1	+	3	4421	c.203C>G	c.(202-204)ACC>AGC	p.T68S	ABP1_uc003whz.1_Missense_Mutation_p.T68S|ABP1_uc003wia.1_Missense_Mutation_p.T68S	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	68					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	GCCAAGAACACCGTGTTTCTC	0.557	Pancreas(195;1227 3054 24912 28503)		NA											50	67					0	0	0.00361	0	0
PTPRN2	5799	broad.mit.edu	37	7	158109546	158109546	+	Missense_Mutation	SNP	C	C	A	rs145815332		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:158109546C>A	uc003wno.2	-	3	363	c.242G>T	c.(241-243)CGC>CTC	p.R81L	PTPRN2_uc003wnp.2_Missense_Mutation_p.R64L|PTPRN2_uc003wnq.2_Missense_Mutation_p.R81L|PTPRN2_uc003wnr.2_Intron|PTPRN2_uc011kwa.1_Missense_Mutation_p.R104L	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	81	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CACGCGCAGGCGCTGCAGGGC	0.642			NA											15	18					1.5739e-10	2.09389e-10	0.004007	1	0
SGCZ	137868	broad.mit.edu	37	8	13965682	13965682	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:13965682G>T	uc003wwq.2	-	6	1270	c.610C>A	c.(610-612)CAA>AAA	p.Q204K	SGCZ_uc010lss.2_Missense_Mutation_p.Q157K	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	191	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTGAGATCTTGGGATGGCTCT	0.438			NA											20	25					1.28384e-07	1.55673e-07	0.012319	1	0
CLU	1191	broad.mit.edu	37	8	27466505	27466505	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:27466505C>T	uc003xfw.1	-	2	254	c.196G>A	c.(196-198)GAG>AAG	p.E66K	CLU_uc010lux.1_Intron|CLU_uc003xfx.1_Missense_Mutation_p.E66K|CLU_uc003xfy.1_Missense_Mutation_p.E77K|CLU_uc003xfz.1_Missense_Mutation_p.E118K	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	66					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		GTCTTGCGCTCTTCGTTTGTT	0.473			NA											6	151					0	0	0.001168	0	0
TEX15	56154	broad.mit.edu	37	8	30695124	30695124	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:30695124C>T	uc003xil.2	-	3	7527	c.7527G>A	c.(7525-7527)TCG>TCA	p.S2509S		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2509										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTGAGAGCACCGACGCATCAG	0.368			NA											26	84					0	0	0.004656	0	0
UNC5D	137970	broad.mit.edu	37	8	35608282	35608282	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:35608282C>A	uc003xjr.1	+	13	2446	c.2118C>A	c.(2116-2118)TAC>TAA	p.Y706*	UNC5D_uc003xjs.1_Nonsense_Mutation_p.Y701*|UNC5D_uc003xju.1_Nonsense_Mutation_p.Y282*	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	706	Cytoplasmic (Potential).|Interaction with DCC (By similarity).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCCTGGATTACAACTTGAGAG	0.448			NA											88	109					2.4313e-29	4.2775e-29	0.00361	1	0
RNF5P1	286140	broad.mit.edu	37	8	38458370	38458370	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:38458370C>T	uc003xly.2	-	1	406	c.349G>A	c.(349-351)GGG>AGG	p.G117R		NR_003129				SubName: Full=Putative uncharacterized protein RNF5;												0						TGGAAGCCCCCGGTATCACCA	0.572			NA											82	90					0	0	0.00361	0	0
SNTG1	54212	broad.mit.edu	37	8	51664619	51664619	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:51664619G>C	uc010lxy.1	+	19	1714	c.1343G>C	c.(1342-1344)AGC>ACC	p.S448T	SNTG1_uc003xqs.1_Missense_Mutation_p.S448T|SNTG1_uc010lxz.1_Intron|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	448					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GATGGCAAGAGCAAAATCAAA	0.358			NA											17	157					0	0	0.010504	0	0
ASPH	444	broad.mit.edu	37	8	62550537	62550537	+	Silent	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:62550537A>G	uc003xuj.2	-	12	1127	c.858T>C	c.(856-858)AAT>AAC	p.N286N	ASPH_uc011leg.1_Silent_p.N257N|ASPH_uc003xuo.2_Silent_p.N267N|ASPH_uc011leh.1_Silent_p.N252N|ASPH_uc003xul.2_Silent_p.N272N|ASPH_uc011lei.1_Silent_p.N271N|ASPH_uc011lej.1_Silent_p.N229N|ASPH_uc003xun.2_Silent_p.N243N|ASPH_uc011lek.1_Silent_p.N267N|ASPH_uc003xum.2_Silent_p.N286N	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	286	Glu-rich.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTTCTACAGGATTATCCTCAG	0.323			NA											8	86					0	0	0.004482	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68131718	68131718	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:68131718C>A	uc003xxo.1	-	30	4676	c.4286G>T	c.(4285-4287)AGA>ATA	p.R1429I	ARFGEF1_uc003xxl.1_Missense_Mutation_p.R883I|ARFGEF1_uc003xxn.1_Missense_Mutation_p.R412I	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1429					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GAAAACAATTCTAAATAAATC	0.318			NA											10	89					7.48243e-07	8.88686e-07	0.006214	1	0
JPH1	56704	broad.mit.edu	37	8	75227183	75227183	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:75227183T>A	uc003yae.2	-	2	1092	c.1052A>T	c.(1051-1053)AAA>ATA	p.K351I	JPH1_uc003yaf.2_Missense_Mutation_p.K351I|JPH1_uc003yag.1_Missense_Mutation_p.K215I	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	351	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CTCCCTAGTTTTTGTATGTCT	0.438			NA											45	201					0	0	0.00361	0	0
JPH1	56704	broad.mit.edu	37	8	75227185	75227185	+	Silent	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:75227185T>G	uc003yae.2	-	2	1090	c.1050A>C	c.(1048-1050)ACA>ACC	p.T350T	JPH1_uc003yaf.2_Silent_p.T350T|JPH1_uc003yag.1_Silent_p.T214T	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	350	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CCCTAGTTTTTGTATGTCTTA	0.443			NA											43	200					0	0	0.00361	0	0
JPH1	56704	broad.mit.edu	37	8	75227187	75227187	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:75227187T>A	uc003yae.2	-	2	1088	c.1048A>T	c.(1048-1050)ACA>TCA	p.T350S	JPH1_uc003yaf.2_Missense_Mutation_p.T350S|JPH1_uc003yag.1_Missense_Mutation_p.T214S	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	350	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CTAGTTTTTGTATGTCTTATT	0.443			NA											52	201					0	0	0.00361	0	0
CNBD1	168975	broad.mit.edu	37	8	88218342	88218342	+	Missense_Mutation	SNP	G	G	C	rs114439288	by1000genomes	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:88218342G>C	uc003ydy.2	+	5	601	c.553G>C	c.(553-555)GAA>CAA	p.E185Q		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	185										ovary(3)	3						TGTCTTTTCCGAAACCTGGTT	0.373			NA											47	30					0	0	0.00361	0	0
DPYS	1807	broad.mit.edu	37	8	105393434	105393434	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:105393434G>T	uc003yly.3	-	9	1681	c.1552C>A	c.(1552-1554)CAC>AAC	p.H518N	DPYS_uc010mcf.1_Missense_Mutation_p.H88N	NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	518					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTCAGGGGTGGGCCTGTTTC	0.507			NA											85	108					9.37156e-40	1.74673e-39	0.00361	1	0
ZFPM2	23414	broad.mit.edu	37	8	106801085	106801085	+	Silent	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:106801085G>C	uc003ymd.2	+	6	695	c.672G>C	c.(670-672)CTG>CTC	p.L224L	ZFPM2_uc011lhs.1_5'UTR	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	224					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CACGCCTGCTGGACTCAATTC	0.498			NA											46	72					0	0	0.00361	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814109	106814109	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:106814109G>T	uc003ymd.2	+	8	1822	c.1799G>T	c.(1798-1800)GGC>GTC	p.G600V	ZFPM2_uc011lhs.1_Missense_Mutation_p.G331V	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	600					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCCAACACTGGCCAAACCTCC	0.463			NA											190	170					7.07375e-107	1.39804e-106	0.00361	1	0
CSMD3	114788	broad.mit.edu	37	8	113293448	113293448	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:113293448A>C	uc003ynu.2	-	59	9622	c.9463T>G	c.(9463-9465)TGC>GGC	p.C3155G	CSMD3_uc003yns.2_Missense_Mutation_p.C2357G|CSMD3_uc003ynt.2_Missense_Mutation_p.C3115G|CSMD3_uc011lhx.1_Missense_Mutation_p.C2986G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3155	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTGGCTGTGCACTGTCTAACT	0.363			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	138					0	0	0.001168	0	0
CSMD3	114788	broad.mit.edu	37	8	113293554	113293554	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:113293554G>A	uc003ynu.2	-	59	9516	c.9357C>T	c.(9355-9357)ACC>ACT	p.T3119T	CSMD3_uc003yns.2_Silent_p.T2321T|CSMD3_uc003ynt.2_Silent_p.T3079T|CSMD3_uc011lhx.1_Silent_p.T2950T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3119	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATTGGCTGTGGTTCCTGGGT	0.368			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	90					0	0	0.004007	0	0
CSMD3	114788	broad.mit.edu	37	8	113694845	113694845	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:113694845G>T	uc003ynu.2	-	16	2662	c.2503C>A	c.(2503-2505)CCT>ACT	p.P835T	CSMD3_uc003yns.2_Missense_Mutation_p.P107T|CSMD3_uc003ynt.2_Missense_Mutation_p.P795T|CSMD3_uc011lhx.1_Missense_Mutation_p.P731T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	835	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCAGGATCAGGGCATTCATTA	0.348			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			91	65					3.17287e-45	5.9879e-45	0.00361	1	0
ENPP2	5168	broad.mit.edu	37	8	120602768	120602768	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:120602768G>T	uc003yot.1	-	13	1270	c.1184C>A	c.(1183-1185)TCC>TAC	p.S395Y	ENPP2_uc003yor.1_Missense_Mutation_p.S34Y|ENPP2_uc003yos.1_Missense_Mutation_p.S447Y|ENPP2_uc010mdd.1_Missense_Mutation_p.S395Y	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	395					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GCTAAATTTGGATCGAATTCT	0.284	Melanoma(20;305 879 2501 4818 31020)		NA											77	40					3.27973e-32	5.88008e-32	0.00361	1	0
BAI1	575	broad.mit.edu	37	8	143614706	143614706	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:143614706G>T	uc003ywm.2	+	24	3632	c.3449G>T	c.(3448-3450)TGG>TTG	p.W1150L		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1150	Helical; Name=6; (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GCGCTGACCTGGATGTCGGCT	0.697			NA											8	20					0.000274275	0.000302385	0.004482	1	0
KIAA2026	158358	broad.mit.edu	37	9	5968614	5968614	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:5968614C>T	uc003zjq.3	-	3	1833	c.1617G>A	c.(1615-1617)CAG>CAA	p.Q539Q		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	539										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AATTATTTTCCTGCTCTTTCT	0.363			NA											75	68					0	0	0.00361	0	0
C9orf93	203238	broad.mit.edu	37	9	15971692	15971692	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:15971692C>A	uc003zmd.2	+	26	4154	c.3839C>A	c.(3838-3840)CCA>CAA	p.P1280Q	C9orf93_uc003zme.2_Missense_Mutation_p.P1195Q|C9orf93_uc011lmu.1_Missense_Mutation_p.P1288Q	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1280											0				GBM - Glioblastoma multiforme(50;4.84e-07)		GATTTCTTACCATTGAAAGCT	0.413			NA											14	225					7.93312e-07	9.39252e-07	0.00245	1	0
LINGO2	158038	broad.mit.edu	37	9	27949528	27949528	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:27949528A>C	uc003zqu.1	-	2	1336	c.1142T>G	c.(1141-1143)ATG>AGG	p.M381R	LINGO2_uc010mjf.1_Missense_Mutation_p.M381R|LINGO2_uc003zqv.1_Missense_Mutation_p.M381R	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	381	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		GCCAGCACACATAGGTTGCTG	0.512			NA											35	26					0	0	0.003271	0	0
CD72	971	broad.mit.edu	37	9	35618283	35618283	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:35618283G>T	uc003zxb.2	-	1	142	c.18C>A	c.(16-18)ACC>ACA	p.T6T	CD72_uc003zxc.1_5'UTR|CD72_uc010mkt.1_5'UTR|CD72_uc010mku.2_Silent_p.T6T|CD72_uc010mkv.2_Silent_p.T6T|CD72_uc010mkw.1_Intron	NM_001782	NP_001773	P21854	CD72_HUMAN	CD72 molecule	6	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity				0			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GATCTGCATAGGTGATGGCCT	0.582			NA											21	15					3.8784e-16	5.79452e-16	0.012319	1	0
ALDH1B1	219	broad.mit.edu	37	9	38396132	38396132	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:38396132G>T	uc004aay.2	+	2	499	c.387G>T	c.(385-387)AAG>AAT	p.K129N		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	129					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	ACAATGGGAAGCCTTTCCAAG	0.577			NA											40	138					2.24893e-16	3.3734e-16	0.009718	1	0
FAM75A6	389730	broad.mit.edu	37	9	43626635	43626635	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:43626635G>C	uc011lrb.1	-	4	2081	c.2052C>G	c.(2050-2052)AGC>AGG	p.S684R		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	684						integral to membrane					0						TCCGTGGGAAGCTTTTCATGT	0.517			NA											3	132					0	0	0.009096	0	0
GDA	9615	broad.mit.edu	37	9	74828893	74828893	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:74828893C>G	uc004aiq.2	+	5	747	c.564C>G	c.(562-564)ATC>ATG	p.I188M	GDA_uc011lse.1_Missense_Mutation_p.I114M|GDA_uc011lsf.1_Missense_Mutation_p.I114M|GDA_uc004air.2_Missense_Mutation_p.I188M|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.I146M|GDA_uc004ait.1_Missense_Mutation_p.I114M	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	188					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		AGGAATCGATCAAGGAAACTG	0.418			NA											10	34					0	0	0.006214	0	0
RASEF	158158	broad.mit.edu	37	9	85619415	85619415	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:85619415G>A	uc004amo.1	-	9	1461	c.1200C>T	c.(1198-1200)GAC>GAT	p.D400D		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	400					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						TAACATACCTGTCATAGCCTA	0.338			NA											20	32					0	0	0.002299	0	0
CDK20	23552	broad.mit.edu	37	9	90588866	90588866	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:90588866C>A	uc004apr.2	-	2	466	c.160G>T	c.(160-162)GCT>TCT	p.A54S	CDK20_uc004aps.2_Missense_Mutation_p.A54S|CDK20_uc004apt.2_Missense_Mutation_p.A67S|CDK20_uc004apu.2_Missense_Mutation_p.A54S	NM_001039803	NP_001034892	Q8IZL9	CDK20_HUMAN	cell cycle related kinase isoform 3	54	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						TCCTGCAGAGCCTTAATCTCC	0.562			NA											150	46					1.3337e-71	2.62213e-71	0.00361	1	0
NXNL2	158046	broad.mit.edu	37	9	91150599	91150599	+	Missense_Mutation	SNP	C	C	A	rs146062765		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:91150599C>A	uc011ltj.1	+	1	584	c.250C>A	c.(250-252)CGC>AGC	p.R84S	NXNL2_uc004aqa.2_Missense_Mutation_p.R84S	NM_001161625	NP_001155097	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2 isoform 1	84	Thioredoxin.										0						GGACTTCATGCGCGAGCTGCA	0.617			NA											58	17					1.48873e-21	2.44762e-21	0.00361	1	0
KIAA1529	57653	broad.mit.edu	37	9	100057180	100057180	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:100057180G>T	uc011lut.1	+	12	1077	c.304G>T	c.(304-306)GTG>TTG	p.V102L	KIAA1529_uc011lur.1_RNA|KIAA1529_uc004axe.1_Missense_Mutation_p.V102L|KIAA1529_uc011lus.1_Intron|KIAA1529_uc010msm.1_RNA	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				CATCAACCCTGTGCTTGTCAG	0.428			NA											10	31					1.61879e-10	2.14227e-10	0.001368	1	0
HEMGN	55363	broad.mit.edu	37	9	100692396	100692396	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:100692396G>C	uc004axy.2	-	3	1389	c.1281C>G	c.(1279-1281)CAC>CAG	p.H427Q	HEMGN_uc004axz.2_Missense_Mutation_p.H427Q	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	427					cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CTGTTTCTTGGTGTGGTTCTG	0.448			NA											3	174					0	0	0.004672	0	0
COL15A1	1306	broad.mit.edu	37	9	101797398	101797398	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:101797398C>A	uc004azb.1	+	18	2388	c.2182C>A	c.(2182-2184)CCC>ACC	p.P728T		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	728	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				ACCCCCTGGGCCCCCAGGCCC	0.572			NA											15	43					4.7546e-09	6.00708e-09	0.004007	1	0
TMEFF1	8577	broad.mit.edu	37	9	103310025	103310025	+	Splice_Site	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:103310025G>T	uc004baz.1	+	6	671	c.561_splice	c.e6-1	p.G187_splice	TMEFF1_uc004bay.1_Splice_Site_p.G261_splice	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two						multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				TTTTCCAACAGGTGTGTATGT	0.348			NA											20	41					4.35082e-09	5.51543e-09	0.010504	1	0
BAAT	570	broad.mit.edu	37	9	104125073	104125073	+	Silent	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:104125073A>C	uc010mtd.2	-	4	1003	c.894T>G	c.(892-894)ACT>ACG	p.T298T	BAAT_uc004bbd.3_Silent_p.T298T	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	298					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	TTGTCTCAAAAGTGCGATAGA	0.453			NA											4	76					0	0	0.009096	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433358	104433358	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:104433358T>C	uc004bbp.1	-	3	1937	c.1336A>G	c.(1336-1338)AGT>GGT	p.S446G	GRIN3A_uc004bbq.1_Missense_Mutation_p.S446G	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	446	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ATGGAACCACTGAGGCCTCTG	0.458			NA											24	66					0	0	0.003954	0	0
TLR4	7099	broad.mit.edu	37	9	120476380	120476380	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:120476380G>T	uc004bjz.2	+	3	2265	c.1974G>T	c.(1972-1974)CTG>CTT	p.L658L	TLR4_uc004bka.2_Silent_p.L618L|TLR4_uc004bkb.2_Silent_p.L458L	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	658	Cytoplasmic (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ATTTTCACCTGATGCTTCTTG	0.433			NA											14	31					3.27435e-08	4.01561e-08	0.00245	1	0
MAPKAP1	79109	broad.mit.edu	37	9	128434679	128434679	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:128434679C>A	uc004bpv.2	-	2	508	c.175G>T	c.(175-177)GGT>TGT	p.G59C	MAPKAP1_uc004bpw.2_Intron|MAPKAP1_uc004bpx.2_Intron|MAPKAP1_uc004bpy.2_Missense_Mutation_p.G59C|MAPKAP1_uc004bpz.2_Missense_Mutation_p.G59C|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc004bqa.2_Missense_Mutation_p.G59C	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	59	Interaction with MAP3K2.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						TGAGTCTCACCATTGCTTCCC	0.433			NA											13	23					1.5842e-08	1.97828e-08	0.001855	1	0
ODF2	4957	broad.mit.edu	37	9	131262412	131262412	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:131262412A>C	uc011mbd.1	+	21	2679	c.2368A>C	c.(2368-2370)AAC>CAC	p.N790H	ODF2_uc004bvb.2_Missense_Mutation_p.N766H|ODF2_uc011mbe.1_Missense_Mutation_p.N785H|ODF2_uc004bvc.2_Missense_Mutation_p.N766H|ODF2_uc004bvd.3_Missense_Mutation_p.N790H|ODF2_uc004bvh.2_Missense_Mutation_p.N196H	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	790	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						CGAGAGCACCAACCGCAGCAT	0.498			NA											5	67					0	0	0.001168	0	0
MXRA5	25878	broad.mit.edu	37	X	3228241	3228241	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:3228241C>G	uc004crg.3	-	7	8160	c.8003G>C	c.(8002-8004)CGT>CCT	p.R2668P		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2668	Ig-like C2-type 11.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCAGGAGAAACGTCCCTGCCC	0.597			NA											30	62					0	0	0.010818	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811257	5811257	+	Silent	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:5811257C>T	uc010ndh.2	-	6	2553	c.2052G>A	c.(2050-2052)TCG>TCA	p.S684S	NLGN4X_uc004crp.2_Silent_p.S704S|NLGN4X_uc004crq.2_Silent_p.S684S|NLGN4X_uc010ndi.2_Silent_p.S721S|NLGN4X_uc004crr.2_Silent_p.S684S|NLGN4X_uc010ndj.2_Silent_p.S684S	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	684	Helical; (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GGAAGAGGAGCGACGCCCCGA	0.527			NA											28	89					0	0	0.00632	0	0
KAL1	3730	broad.mit.edu	37	X	8503631	8503631	+	Splice_Site	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:8503631C>A	uc004csf.2	-	12	1992	c.1842_splice	c.e12+1	p.S614_splice		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor						axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						GTGGGACCTACGGAAGGCAGG	0.493			NA											12	33					1.08611e-07	1.32123e-07	0.010729	1	0
TLR7	51284	broad.mit.edu	37	X	12905272	12905272	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:12905272T>A	uc004cvc.2	+	3	1784	c.1645T>A	c.(1645-1647)TTC>ATC	p.F549I		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	549	Extracellular (Potential).|LRR 18.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ATATTTGGACTTCTCCAACAA	0.388			NA											213	381					0	0	0.00361	0	0
GLRA2	2742	broad.mit.edu	37	X	14627195	14627195	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:14627195G>T	uc010nep.2	+	8	1130	c.798G>T	c.(796-798)CTG>CTT	p.L266L	GLRA2_uc010neq.2_Silent_p.L266L|GLRA2_uc004cwe.3_Silent_p.L266L|GLRA2_uc011mio.1_Silent_p.L177L|GLRA2_uc011mip.1_Silent_p.L244L	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	266	Helical; (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	TCCCAAGCCTGCTTATAGTAA	0.453			NA											58	132					3.7469e-33	6.7498e-33	0.00361	1	0
GRPR	2925	broad.mit.edu	37	X	16142118	16142118	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:16142118C>A	uc004cxj.2	+	1	695	c.42C>A	c.(40-42)GAC>GAA	p.D14E		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	14	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					TGGAGGTGGACCATTTCATGC	0.453			NA									OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	134	272					1.0049e-60	1.94522e-60	0.00361	1	0
DCAF8L2	347442	broad.mit.edu	37	X	27766660	27766660	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:27766660C>A	uc011mjy.1	+	1	1735	c.1648C>A	c.(1648-1650)CTT>ATT	p.L550I		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						TGCCACTGAGCTTACTGGGTT	0.488			NA											9	20					9.70103e-10	1.25298e-09	0.008291	1	0
MAGEB10	139422	broad.mit.edu	37	X	27839829	27839829	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:27839829G>T	uc004dbw.2	+	3	633	c.406G>T	c.(406-408)GAT>TAT	p.D136Y		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	136	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						TACAAAGGCAGATATGCTGAG	0.443			NA											37	73					1.59932e-28	2.78771e-28	0.007835	1	0
MAGEB3	4114	broad.mit.edu	37	X	30254366	30254366	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:30254366G>T	uc004dca.1	+	5	1062	c.325G>T	c.(325-327)GAC>TAC	p.D109Y		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	109											0						GTCTCGCACAGACCCTCTAAT	0.398			NA											17	51					2.48551e-13	3.47878e-13	0.00499	1	0
DMD	1756	broad.mit.edu	37	X	31462617	31462617	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:31462617G>T	uc004dda.1	-	60	9309	c.9065C>A	c.(9064-9066)ACC>AAC	p.T3022N	DMD_uc004dcq.1_Missense_Mutation_p.T293N|DMD_uc004dcr.1_Missense_Mutation_p.T562N|DMD_uc004dcs.1_Missense_Mutation_p.T562N|DMD_uc004dct.1_Missense_Mutation_p.T562N|DMD_uc004dcu.1_Missense_Mutation_p.T562N|DMD_uc004dcv.1_Missense_Mutation_p.T562N|DMD_uc004dcw.2_Missense_Mutation_p.T1678N|DMD_uc004dcx.2_Missense_Mutation_p.T1681N|DMD_uc004dcz.2_Missense_Mutation_p.T2899N|DMD_uc004dcy.1_Missense_Mutation_p.T3018N|DMD_uc004ddb.1_Missense_Mutation_p.T3014N	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3022	Spectrin 22.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTTCCATCTGGTGTTCAGGTC	0.413			NA											56	72					2.18419e-29	3.85175e-29	0.00361	1	0
OTC	5009	broad.mit.edu	37	X	38271170	38271170	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:38271170C>A	uc004def.3	+	9	1137	c.923C>A	c.(922-924)CCA>CAA	p.P308Q		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	308					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	CCCAGAAAGCCAGAAGAAGTG	0.423			NA											89	153					7.61764e-41	1.42335e-40	0.00361	1	0
RP2	6102	broad.mit.edu	37	X	46713296	46713296	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:46713296G>T	uc004dgw.3	+	2	677	c.488G>T	c.(487-489)GGG>GTG	p.G163V		NM_006915	NP_008846	O75695	XRP2_HUMAN	XRP2 protein	163	C-CAP/cofactor C-like.				cell morphogenesis|CTP biosynthetic process|GTP biosynthetic process|protein folding|UTP biosynthetic process|visual perception	cytoplasm|plasma membrane	ATP binding|GTP binding|GTPase activator activity|nucleoside diphosphate kinase activity|unfolded protein binding				0						AAAGATGCAGGGCTAAGTATC	0.408			NA											49	82					1.63038e-21	2.67467e-21	0.00361	1	0
ZNF157	7712	broad.mit.edu	37	X	47272883	47272883	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:47272883G>T	uc004dhr.1	+	4	1480	c.1411G>T	c.(1411-1413)GAG>TAG	p.E471*		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	471	C2H2-type 12.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAGACCCTTTGAGTGTCAAGA	0.453			NA											18	31					1.00905e-13	1.42822e-13	0.008871	1	0
SSX6	280657	broad.mit.edu	37	X	47969414	47969414	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:47969414A>T	uc004dix.1	+	2	173	c.51A>T	c.(49-51)GCA>GCT	p.A17A	SSX6_uc011mlv.1_Silent_p.A17A	NM_173357	NP_775493			SubName: Full=Putative uncharacterized protein SSX1;												0						ATGCTAAAGCATCAGAGAAGA	0.567			NA											41	55					0	0	0.010771	0	0
EBP	10682	broad.mit.edu	37	X	48386709	48386709	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:48386709G>A	uc004djx.3	+	5	762	c.557G>A	c.(556-558)TGG>TAG	p.W186*	EBP_uc004djy.3_Nonsense_Mutation_p.W186*|EBP_uc004djz.2_Nonsense_Mutation_p.W186*	NM_006579	NP_006570	Q15125	EBP_HUMAN	emopamil binding protein (sterol isomerase)	186	Helical; (Potential).				cholesterol biosynthetic process|skeletal system development	endoplasmic reticulum membrane|integral to plasma membrane	cholestenol delta-isomerase activity|drug transmembrane transporter activity|steroid delta-isomerase activity|transmembrane receptor activity			ovary(1)	1						CTCTACTTCTGGTTTTACTTT	0.567	Ovarian(41;550 1000 33077 33474 52335)		NA											3	23					0	0	0.004672	0	0
ERAS	3266	broad.mit.edu	37	X	48687822	48687822	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:48687822G>A	uc004dky.1	+	1	540	c.289G>A	c.(289-291)GCA>ACA	p.A97T		NM_181532	NP_853510	Q7Z444	RASE_HUMAN	ES cell expressed Ras precursor	97	GTP (By similarity).				small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			lung(4)|urinary_tract(1)	5						GCTGGACACAGCAGGGCAGGC	0.602			NA											31	86					0	0	0.003271	0	0
PPP1R3F	89801	broad.mit.edu	37	X	49142649	49142649	+	Silent	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:49142649A>T	uc004dnh.1	+	4	1513	c.1497A>T	c.(1495-1497)CTA>CTT	p.L499L	PPP1R3F_uc011mnd.1_Silent_p.L170L|PPP1R3F_uc004dni.2_Silent_p.L153L|PPP1R3F_uc004dnj.1_Silent_p.L153L	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	499	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					TGAGCCGCCTACGGGCTGCTG	0.682			NA											3	19					0	0	0.004672	0	0
CCNB3	85417	broad.mit.edu	37	X	50053545	50053545	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:50053545G>A	uc004dox.3	+	6	2674	c.2376G>A	c.(2374-2376)GCG>GCA	p.A792A	CCNB3_uc004doy.2_Silent_p.A792A|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	792					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CCAGCATTGCGGAGGGGGAGA	0.517			NA											4	21					0	0	0.009096	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377002	50377002	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:50377002G>T	uc004dpe.2	-	4	2097	c.2071C>A	c.(2071-2073)CCT>ACT	p.P691T	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.P575T	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	691					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GACTGGCCAGGCCTCTGGCCA	0.582			NA											22	17					3.85864e-22	6.39991e-22	0.00278	1	0
MAGED1	9500	broad.mit.edu	37	X	51641289	51641289	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:51641289G>T	uc004dpm.2	+	8	1833	c.1738G>T	c.(1738-1740)GCT>TCT	p.A580S	MAGED1_uc004dpn.2_Missense_Mutation_p.A636S|MAGED1_uc004dpo.2_Missense_Mutation_p.A580S	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	580	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					TGCCAGTGAGGGTGAGTGGCT	0.532			NA								Multiple Myeloma(10;0.10)			31	54					8.88839e-20	1.415e-19	0.010818	1	0
MAGED1	9500	broad.mit.edu	37	X	51641678	51641678	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:51641678G>T	uc004dpm.2	+	10	1878	c.1783G>T	c.(1783-1785)GTG>TTG	p.V595L	MAGED1_uc004dpn.2_Missense_Mutation_p.V651L|MAGED1_uc004dpo.2_Missense_Mutation_p.V595L	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	595	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					TACCTTCAGGGTGAGACATCC	0.443			NA								Multiple Myeloma(10;0.10)			4	41					0.00909568	0.0095258	0.009096	1	0
TSPYL2	64061	broad.mit.edu	37	X	53114989	53114989	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:53114989T>G	uc004drw.2	+	6	1547	c.1415T>G	c.(1414-1416)ATC>AGC	p.I472S	TSPYL2_uc004drv.2_3'UTR|TSPYL2_uc004drx.1_Missense_Mutation_p.I77S	NM_022117	NP_071400	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	472					cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding				0						ATAACTGACATCAATGAGAAC	0.338			NA											37	66					0	0	0.005524	0	0
WNK3	65267	broad.mit.edu	37	X	54337611	54337611	+	Silent	SNP	T	T	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:54337611T>C	uc004dtd.1	-	3	1090	c.651A>G	c.(649-651)TTA>TTG	p.L217L	WNK3_uc004dtc.1_Silent_p.L217L	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	217	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TCTTTCCTTTTAATATAGATT	0.383			NA											32	31					0	0	0.009535	0	0
TRO	7216	broad.mit.edu	37	X	54950180	54950180	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:54950180C>A	uc004dtq.2	+	3	1322	c.1215C>A	c.(1213-1215)ACC>ACA	p.T405T	TRO_uc011moj.1_Silent_p.T348T|TRO_uc004dts.2_Silent_p.T405T|TRO_uc004dtr.2_Silent_p.T405T|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	405					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CAACCAGGACCCGGGGCAAAA	0.478			NA											6	11					0.00116845	0.00125871	0.001168	1	0
MTMR8	55613	broad.mit.edu	37	X	63490885	63490885	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:63490885A>T	uc004dvs.2	-	13	1618	c.1550T>A	c.(1549-1551)CTC>CAC	p.L517H	MTMR8_uc011mou.1_Intron	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	517	Potential.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AATTTCCAGGAGGCTCTCTAG	0.468			NA											9	44					0	0	0.008291	0	0
PJA1	64219	broad.mit.edu	37	X	68381543	68381543	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:68381543G>A	uc004dxh.2	-	2	1825	c.1539C>T	c.(1537-1539)CTC>CTT	p.L513L	PJA1_uc011mpi.1_Silent_p.L231L|PJA1_uc004dxg.2_Silent_p.L325L|PJA1_uc004dxi.2_Silent_p.L458L	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	513							zinc ion binding				0						ATCCATCAAAGAGGCTCCAAT	0.507			NA											26	117					0	0	0.00333	0	0
PJA1	64219	broad.mit.edu	37	X	68381584	68381584	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:68381584C>T	uc004dxh.2	-	2	1784	c.1498G>A	c.(1498-1500)GAC>AAC	p.D500N	PJA1_uc011mpi.1_Missense_Mutation_p.D218N|PJA1_uc004dxg.2_Missense_Mutation_p.D312N|PJA1_uc004dxi.2_Missense_Mutation_p.D445N	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	500							zinc ion binding				0						ACACTGGAGTCATCTTCAAGG	0.483			NA											70	134					0	0	0.00361	0	0
MED12	9968	broad.mit.edu	37	X	70345279	70345279	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:70345279C>A	uc004dyy.2	+	16	2504	c.2305C>A	c.(2305-2307)CAT>AAT	p.H769N	MED12_uc011mpq.1_Missense_Mutation_p.H769N|MED12_uc004dyz.2_Missense_Mutation_p.H769N|MED12_uc004dza.2_Missense_Mutation_p.H616N	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	769					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGATGCCCGCCATGCCATCAA	0.532			NA											12	32					5.50884e-06	6.37197e-06	0.001368	1	0
NLGN3	54413	broad.mit.edu	37	X	70389915	70389915	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:70389915C>A	uc004dzb.2	+	7	2759	c.2455C>A	c.(2455-2457)CTG>ATG	p.L819M	NLGN3_uc004dzc.2_Missense_Mutation_p.L702M|NLGN3_uc011mps.1_Missense_Mutation_p.L799M|NLGN3_uc004dze.2_Missense_Mutation_p.L637M	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	839	Cytoplasmic (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					CAGTACCGGGCTGCCCCACTC	0.537	Esophageal Squamous(103;760 1488 16849 22250 40351)		NA											7	24					0.00198382	0.00211889	0.001984	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912725	77912725	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:77912725G>T	uc004edc.1	-	2	1489	c.1193C>A	c.(1192-1194)CCC>CAC	p.P398H		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	398							nucleic acid binding|zinc ion binding			ovary(1)	1						TAATGGATTGGGATCAGGCTT	0.507			NA											71	67					6.5469e-37	1.20829e-36	0.00361	1	0
ITM2A	9452	broad.mit.edu	37	X	78616925	78616925	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:78616925C>T	uc004edh.2	-	5	939	c.604G>A	c.(604-606)GTG>ATG	p.V202M	ITM2A_uc011mqr.1_Missense_Mutation_p.V158M	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	202	BRICHOS.					integral to membrane	protein binding			lung(2)	2						ATTTCCTCCACAGCAACTAGG	0.388			NA											5	60					0	0	0.001168	0	0
HDX	139324	broad.mit.edu	37	X	83599332	83599332	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:83599332G>C	uc004eek.1	-	6	1695	c.1586C>G	c.(1585-1587)GCT>GGT	p.A529G	HDX_uc011mqv.1_Missense_Mutation_p.A529G|HDX_uc004eel.1_Missense_Mutation_p.A471G	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	529						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TTCAGGCCCAGCTTCCTCTCC	0.453	Pancreas(53;231 1169 36156 43751 51139)		NA											22	83					0	0	0.010504	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927894	92927894	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:92927894G>T	uc004efq.2	-	1	715	c.410C>A	c.(409-411)GCT>GAT	p.A137D	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	137					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						GTTGAGTTCAGCATATTTTCT	0.388			NA											25	47					8.24728e-16	1.22008e-15	0.004656	1	0
PCDH19	57526	broad.mit.edu	37	X	99657617	99657617	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:99657617G>T	uc010nmz.2	-	3	4197	c.2521C>A	c.(2521-2523)CGC>AGC	p.R841S	PCDH19_uc004efw.3_Missense_Mutation_p.R794S|PCDH19_uc004efx.3_Missense_Mutation_p.R794S	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	841	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CTGGTGTTGCGGGTATTCTGG	0.567			NA											21	34					9.95505e-16	1.46409e-15	0.002299	1	0
BTK	695	broad.mit.edu	37	X	100626677	100626677	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:100626677C>A	uc004ehg.2	-	4	446	c.253G>T	c.(253-255)GAG>TAG	p.E85*	BTK_uc010nnn.2_Nonsense_Mutation_p.E85*|BTK_uc010nno.2_Nonsense_Mutation_p.E119*|BTK_uc004ehi.2_Nonsense_Mutation_p.E85*	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	85	PH.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TCACTGGACTCTTCACCTCTT	0.393			NA							Agammaglobulinemia_X-linked				9	149					2.74318e-10	3.61754e-10	0.006214	1	0
ARMCX2	9823	broad.mit.edu	37	X	100911043	100911043	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:100911043G>T	uc004eid.2	-	3	1887	c.1532C>A	c.(1531-1533)GCA>GAA	p.A511E	ARMCX2_uc004eie.3_Missense_Mutation_p.A511E|ARMCX2_uc004eif.3_Missense_Mutation_p.A511E|ARMCX2_uc004eig.3_Missense_Mutation_p.A511E|ARMCX2_uc010nnt.2_Missense_Mutation_p.A511E	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	511	ARM 3.					integral to membrane	binding			ovary(6)	6						GAAAAAGTTTGCAATGGAATT	0.368			NA											118	187					3.08405e-71	6.04763e-71	0.00361	1	0
MORF4L2	9643	broad.mit.edu	37	X	102931676	102931676	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:102931676C>A	uc004ekw.2	-	4	1512	c.280G>T	c.(280-282)GCA>TCA	p.A94S	MORF4L2_uc004ela.2_Missense_Mutation_p.A94S|MORF4L2_uc004ekx.2_Missense_Mutation_p.A94S|MORF4L2_uc004elb.2_Missense_Mutation_p.A94S|MORF4L2_uc004eky.2_Missense_Mutation_p.A94S|MORF4L2_uc010nos.2_Missense_Mutation_p.A94S|MORF4L2_uc004ekz.2_Missense_Mutation_p.A94S|MORF4L2_uc011mry.1_Missense_Mutation_p.A94S|MORF4L2_uc011mrz.1_Missense_Mutation_p.A94S|MORF4L2_uc004elc.2_Missense_Mutation_p.A94S|MORF4L2_uc004elf.2_Missense_Mutation_p.A94S|MORF4L2_uc004ele.2_Missense_Mutation_p.A94S|MORF4L2_uc011msa.1_Missense_Mutation_p.A94S|MORF4L2_uc011msb.1_Missense_Mutation_p.A94S|MORF4L2_uc011msc.1_Missense_Mutation_p.A94S|MORF4L2_uc011msd.1_Missense_Mutation_p.A94S|MORF4L2_uc004eld.2_Missense_Mutation_p.A94S	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	94					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						GGCTGAGGTGCTTCGCTGGTA	0.537			NA											11	174					3.86212e-05	4.37978e-05	0.008291	1	0
ESX1	80712	broad.mit.edu	37	X	103495020	103495020	+	Silent	SNP	C	C	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:103495020C>G	uc004ely.2	-	4	1168	c.1110G>C	c.(1108-1110)CCG>CCC	p.P370P		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	370	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.|15.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCGCCATGGGCGGCCCGGGTG	0.697	Pancreas(200;1705 2227 25194 28471 45274)		NA											14	33					0	0	0.001855	0	0
CLDN2	9075	broad.mit.edu	37	X	106171518	106171518	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:106171518C>A	uc004emq.1	+	2	579	c.60C>A	c.(58-60)GGC>GGA	p.G20G	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Silent_p.G20G	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	20	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						GGCTTTTGGGCACACTGGTTG	0.557			NA											42	65					4.44401e-20	7.10476e-20	0.010771	1	0
COL4A6	1288	broad.mit.edu	37	X	107402768	107402768	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:107402768A>T	uc004enw.3	-	44	4842	c.4739T>A	c.(4738-4740)GTG>GAG	p.V1580E	COL4A6_uc004env.3_Missense_Mutation_p.V1579E|COL4A6_uc011msn.1_Missense_Mutation_p.V1555E|COL4A6_uc010npk.2_Missense_Mutation_p.V1522E|COL4A6_uc011msm.1_Missense_Mutation_p.V114E|COL4A6_uc010npj.2_Missense_Mutation_p.V59E	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1580	Collagen IV NC1.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CTGGCTGTGCACAGCAATGGC	0.612	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				35	59					0	0	0.00874	0	0
COL4A5	1287	broad.mit.edu	37	X	107807133	107807133	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:107807133C>A	uc004enz.1	+	4	455	c.253C>A	c.(253-255)CCA>ACA	p.P85T	COL4A5_uc011mso.1_Missense_Mutation_p.P85T	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	85	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AATTCCAGGGCCACCAGGACC	0.328			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				13	29					1.15088e-07	1.39776e-07	0.004007	1	0
COL4A5	1287	broad.mit.edu	37	X	107935990	107935990	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:107935990G>T	uc004enz.1	+	49	4743	c.4541G>T	c.(4540-4542)AGC>ATC	p.S1514I	COL4A5_uc011mso.1_Missense_Mutation_p.S1511I|COL4A5_uc011msp.1_Missense_Mutation_p.S190I	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1508	Collagen IV NC1.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						ACGGCTGGCAGCTGCCTTCGT	0.408			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				14	85					1.3612e-06	1.60154e-06	0.003163	1	0
IRS4	8471	broad.mit.edu	37	X	107979482	107979482	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:107979482G>T	uc004eoc.2	-	1	126	c.93C>A	c.(91-93)ACC>ACA	p.T31T		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	31						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GAAGCGGGGTGGTCACCACTG	0.642			NA											20	54					2.4624e-09	3.15337e-09	0.008871	1	0
TRPC5	7224	broad.mit.edu	37	X	111025234	111025234	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:111025234A>G	uc004epl.1	-	8	2948	c.2029T>C	c.(2029-2031)TTC>CTC	p.F677L	TRPC5_uc004epm.1_Missense_Mutation_p.F677L	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	677	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						GTGTTGTTGAACCAGTTACCA	0.448			NA											15	237					0	0	0.007413	0	0
PLS3	5358	broad.mit.edu	37	X	114856611	114856611	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:114856611G>C	uc004eqd.2	+	3	517	c.127G>C	c.(127-129)GAA>CAA	p.E43Q	PLS3_uc010nqf.2_RNA|PLS3_uc010nqg.2_Missense_Mutation_p.E43Q|PLS3_uc011mtf.1_Missense_Mutation_p.E21Q|PLS3_uc004eqe.2_Missense_Mutation_p.E43Q|PLS3_uc011mtg.1_Missense_Mutation_p.E43Q|PLS3_uc011mth.1_5'UTR	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	43	EF-hand 1.					cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						GCTCTTCAAGGAAGCTAATAT	0.348	Colon(160;1047 1864 8490 12969 29601)		NA											56	93					0	0	0.00361	0	0
UPF3B	65109	broad.mit.edu	37	X	118979170	118979170	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:118979170T>A	uc004erz.1	-	4	537	c.460A>T	c.(460-462)ATC>TTC	p.I154F	UPF3B_uc004esa.1_Missense_Mutation_p.I154F	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	154	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						CCATCATCGATAGTCCCGACT	0.333			NA											24	152					0	0	0.004656	0	0
RNF113A	7737	broad.mit.edu	37	X	119004598	119004598	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:119004598C>A	uc004esb.2	-	1	1194	c.979G>T	c.(979-981)GGT>TGT	p.G327C	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	327							nucleic acid binding|zinc ion binding			breast(2)	2						TCGGAAGCACCACCCTCTCCT	0.443			NA											117	217					2.78246e-50	5.33127e-50	0.00361	1	0
CUL4B	8450	broad.mit.edu	37	X	119694176	119694176	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:119694176G>T	uc004esw.2	-	3	809	c.372C>A	c.(370-372)ACC>ACA	p.T124T	CUL4B_uc004esv.2_Silent_p.T106T	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	124	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						CAAACTCCAGGGTGTCTTCAA	0.473			NA											17	77					3.51602e-12	4.84015e-12	0.008871	1	0
THOC2	57187	broad.mit.edu	37	X	122840794	122840794	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:122840794G>T	uc004etu.2	-	3	168	c.136C>A	c.(136-138)CAG>AAG	p.Q46K	THOC2_uc011muh.1_5'UTR|THOC2_uc011mui.1_5'UTR	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	46					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						AGAGCTTGCTGGAAATCTGTT	0.299			NA											6	22					0.00116845	0.00125871	0.001168	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125686305	125686305	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:125686305G>C	uc004eul.2	-	1	538	c.287C>G	c.(286-288)ACG>AGG	p.T96R		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	96										skin(3)|ovary(1)	4						CTTGTTGACCGTGCCCAGCTC	0.657			NA											22	58					0	0	0.002299	0	0
OCRL	4952	broad.mit.edu	37	X	128699806	128699806	+	Silent	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:128699806G>A	uc004euq.2	+	13	1467	c.1302G>A	c.(1300-1302)GAG>GAA	p.E434E	OCRL_uc004eur.2_Silent_p.E434E	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	434					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						ATGCCAATGAGGTGAAAAGTC	0.358			NA											78	161					0	0	0.00361	0	0
RAB33A	9363	broad.mit.edu	37	X	129318489	129318489	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:129318489C>A	uc004evl.2	+	2	753	c.489C>A	c.(487-489)TCC>TCA	p.S163S	RAB33A_uc010nre.2_RNA	NM_004794	NP_004785	Q14088	RB33A_HUMAN	Ras-related protein Rab-33A	163					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding				0						AGGTGCCCTCCAACTTAGCCC	0.517			NA											15	49					6.31663e-08	7.72146e-08	0.003163	1	0
GPR119	139760	broad.mit.edu	37	X	129518863	129518863	+	Missense_Mutation	SNP	C	C	A	rs142057970		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:129518863C>A	uc011muv.1	-	1	559	c.559G>T	c.(559-561)GAC>TAC	p.D187Y		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	187	Cytoplasmic (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						TTGAGCATGTCGCAGTAGAAG	0.542			NA											40	48					9.88483e-10	1.27453e-09	0.007835	1	0
CCDC160	347475	broad.mit.edu	37	X	133378823	133378823	+	Translation_Start_Site	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:133378823C>A	uc011mvj.1	+	2	314	c.-7C>A	c.(-9--5)GCCTG>GCATG			NM_001101357	NP_001094827	A6NGH7	CC160_HUMAN	coiled-coil domain containing 160											skin(1)	1						GAAGAGGTGCCTGGAGAAATG	0.358			NA											6	9					0.00198382	0.00211889	0.001984	1	0
GPR112	139378	broad.mit.edu	37	X	135428831	135428831	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:135428831C>A	uc004ezu.1	+	6	3257	c.2966C>A	c.(2965-2967)TCC>TAC	p.S989Y	GPR112_uc010nsb.1_Missense_Mutation_p.S784Y|GPR112_uc010nsc.1_Missense_Mutation_p.S756Y	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	989	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACAGCTACGTCCTTGTCTGAT	0.493			NA											116	175					1.14936e-50	2.20784e-50	0.00361	1	0
BRS3	680	broad.mit.edu	37	X	135574143	135574143	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:135574143C>A	uc004ezv.1	+	3	958	c.809C>A	c.(808-810)GCC>GAC	p.A270D		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	270	Cytoplasmic (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AAGAGAATTGCCAGAACGGTA	0.328			NA											57	75					5.12918e-33	9.21783e-33	0.00361	1	0
GPR101	83550	broad.mit.edu	37	X	136112902	136112902	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:136112902G>T	uc011mwh.1	-	1	932	c.932C>A	c.(931-933)ACG>AAG	p.T311K		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCTGGCCACCGTGCTGCTCTC	0.607			NA											122	184					9.48018e-61	1.83984e-60	0.00361	1	0
ZIC3	7547	broad.mit.edu	37	X	136652125	136652125	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:136652125G>T	uc004fak.2	+	3	1805	c.1300G>T	c.(1300-1302)GCT>TCT	p.A434S		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	434					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ACCCGCTATAGCTTCTGCAAA	0.428			NA											94	167					1.42366e-38	2.64695e-38	0.00361	1	0
FGF13	2258	broad.mit.edu	37	X	137939714	137939714	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:137939714C>A	uc004faq.2	-	2	353	c.177G>T	c.(175-177)CCG>CCT	p.P59P	FGF13_uc011mwi.1_Silent_p.P30P|FGF13_uc004far.2_Silent_p.P30P|FGF13_uc011mwj.1_Silent_p.P59P|FGF13_uc011mwk.1_Intron	NM_001139502	NP_001132974	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 3	198					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CTTGCTTCAGCGGGCAGCAGA	0.433			NA											60	124					9.68594e-22	1.59595e-21	0.00361	1	0
FGF13	2258	broad.mit.edu	37	X	137939775	137939775	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:137939775G>A	uc004faq.2	-	2	292	c.116C>T	c.(115-117)GCG>GTG	p.A39V	FGF13_uc011mwi.1_Missense_Mutation_p.A10V|FGF13_uc004far.2_Missense_Mutation_p.A10V|FGF13_uc011mwj.1_Missense_Mutation_p.A39V|FGF13_uc011mwk.1_Intron	NM_001139502	NP_001132974	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 3	Error:Variant_position_missing_in_Q92913_after_alignment					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CTTTAATTCCGCAGATTGGAT	0.463			NA											24	74					0	0	0.002299	0	0
ATP11C	286410	broad.mit.edu	37	X	138908907	138908907	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:138908907A>T	uc004faz.2	-	2	211	c.112T>A	c.(112-114)TAC>AAC	p.Y38N	ATP11C_uc004fba.2_Missense_Mutation_p.Y38N	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	38	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TGTGCAATGTAAGCTTCTGTT	0.363			NA											32	50					0	0	0.009535	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795404	142795404	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:142795404C>A	uc004fbz.2	-	2	1028	c.274G>T	c.(274-276)GCT>TCT	p.A92S		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	92										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GATCCTTCAGCTGAGTCTAGG	0.498			NA											178	388					2.02162e-65	3.95398e-65	0.00361	1	0
AFF2	2334	broad.mit.edu	37	X	148072807	148072807	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:148072807T>A	uc004fcp.2	+	21	4360	c.3881T>A	c.(3880-3882)GTC>GAC	p.V1294D	AFF2_uc004fcq.2_Missense_Mutation_p.V1284D|AFF2_uc004fcr.2_Missense_Mutation_p.V1255D|AFF2_uc011mxb.1_Missense_Mutation_p.V1259D|AFF2_uc004fcs.2_Missense_Mutation_p.V1259D|AFF2_uc011mxc.1_Missense_Mutation_p.V935D	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1294					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACCAATCTTGTCCGCTACGTT	0.522			NA											93	136					0	0	0.00361	0	0
MTMR1	8776	broad.mit.edu	37	X	149905222	149905222	+	Silent	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:149905222G>C	uc004fei.2	+	10	1347	c.1212G>C	c.(1210-1212)GTG>GTC	p.V404V	MTMR1_uc011mya.1_Silent_p.V310V|MTMR1_uc004feh.1_Silent_p.V412V|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_Intron	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	404	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCAATGTGGATGGGACGC	0.438			NA											22	49					0	0	0.002299	0	0
HMGB3	3149	broad.mit.edu	37	X	150156302	150156302	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:150156302C>A	uc004fep.2	+	5	610	c.518C>A	c.(517-519)GCT>GAT	p.A173D	HMGB3_uc004feq.2_3'UTR|HMGB3_uc004fer.2_Missense_Mutation_p.A173D	NM_005342	NP_005333	O15347	HMGB3_HUMAN	high-mobility group box 3	173					DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGGTCCTGCTAAAGTTGCC	0.279			NA											54	74					1.54886e-18	2.39485e-18	0.00361	1	0
PASD1	139135	broad.mit.edu	37	X	150817161	150817161	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:150817161C>A	uc004fev.3	+	9	1036	c.704C>A	c.(703-705)GCT>GAT	p.A235D		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	235	Poly-Ala.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					gctgctgctgctgctATCTCA	0.348			NA											63	99					4.09171e-25	6.95498e-25	0.00361	1	0
GABRA3	2556	broad.mit.edu	37	X	151514097	151514097	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:151514097C>T	uc010ntk.1	-	3	458	c.218G>A	c.(217-219)CGT>CAT	p.R73H		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	73	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTCCAGAAGACGATCCAAGAT	0.473	NSCLC(142;2578 2613 10251 16743)		NA											22	98					0	0	0.012319	0	0
GABRQ	55879	broad.mit.edu	37	X	151821209	151821209	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:151821209C>A	uc004ffp.1	+	9	1384	c.1364C>A	c.(1363-1365)TCC>TAC	p.S455Y		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	455						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GATCTCCCCTCCACCTCAGAG	0.597			NA											56	90					1.44317e-28	2.52136e-28	0.00361	1	0
ATP2B3	492	broad.mit.edu	37	X	152825205	152825205	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:152825205G>T	uc004fht.1	+	16	2770	c.2644G>T	c.(2644-2646)GTG>TTG	p.V882L	ATP2B3_uc004fhs.1_Missense_Mutation_p.V882L|ATP2B3_uc010nuf.1_5'Flank|ATP2B3_uc004fhu.1_5'Flank	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	882	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTCAAAGCCGTGCAGATGTT	0.617			NA											20	44					1.01871e-10	1.36251e-10	0.008871	1	0
DUSP9	1852	broad.mit.edu	37	X	152914962	152914962	+	Silent	SNP	C	C	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:152914962C>A	uc004fhx.3	+	3	853	c.649C>A	c.(649-651)CGG>AGG	p.R217R	DUSP9_uc004fhy.3_Silent_p.R217R	NM_001395	NP_001386	Q99956	DUS9_HUMAN	dual specificity phosphatase 9	217	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGCAGTGCCCGGGATTCCGC	0.597			NA											33	66					4.74835e-14	6.759e-14	0.010818	1	0
AVPR2	554	broad.mit.edu	37	X	153171777	153171777	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:153171777A>G	uc004fjh.3	+	2	888	c.817A>G	c.(817-819)ACG>GCG	p.T273A	AVPR2_uc004fjg.3_Missense_Mutation_p.T62A|AVPR2_uc004fji.2_Missense_Mutation_p.T273A	NM_000054	NP_000045	P30518	V2R_HUMAN	arginine vasopressin receptor 2 isoform 1	273	Helical; Name=6; (Potential).				activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	TGTGAGGATGACGCTAGTGAT	0.672			NA											3	133					0	0	0.004672	0	0
RENBP	5973	broad.mit.edu	37	X	153209095	153209095	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:153209095C>T	uc004fjo.1	-	5	535	c.365G>A	c.(364-366)GGC>GAC	p.G122D	RENBP_uc011mzh.1_Missense_Mutation_p.G122D	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	122					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GACCGGGCGGCCGTCCCGAGT	0.612			NA											4	109					0	0	0.009096	0	0
HCFC1	3054	broad.mit.edu	37	X	153222985	153222985	+	Splice_Site	SNP	C	C	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:153222985C>T	uc004fjp.2	-	13	2662	c.2134_splice	c.e13-1	p.T712_splice		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1						cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCCTTTGGTCTGAAAGGGGG	0.627			NA											31	31					0	0	0.007291	0	0
FLNA	2316	broad.mit.edu	37	X	153581773	153581773	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:153581773G>C	uc004fkk.2	-	37	6162	c.5913C>G	c.(5911-5913)ATC>ATG	p.I1971M	FLNA_uc004fki.2_Missense_Mutation_p.I14M|FLNA_uc011mzn.1_Missense_Mutation_p.I104M|FLNA_uc010nuu.1_Missense_Mutation_p.I1963M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1971	Filamin 18.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTTGATGGGGATGTCGGCAG	0.632			NA											34	65					0	0	0.003755	0	0
SLC10A3	8273	broad.mit.edu	37	X	153716929	153716929	+	Silent	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:153716929G>T	uc004flq.2	-	3	615	c.351C>A	c.(349-351)ATC>ATA	p.I117I	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Silent_p.I117I|SLC10A3_uc004flp.2_Silent_p.I117I	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	117					organic anion transport	integral to membrane	bile acid:sodium symporter activity			ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCACGTTCTTGATGGTCAGCA	0.637			NA											4	143					2.56e-06	2.97941e-06	0.009096	1	0
IKBKG	8517	broad.mit.edu	37	X	153780355	153780355	+	Silent	SNP	C	C	A	rs149511938	byFrequency	TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:153780355C>A	uc004fmb.3	+	2	552	c.138C>A	c.(136-138)GGC>GGA	p.G46G	IKBKG_uc011mzr.1_Silent_p.G114G|IKBKG_uc010nva.2_Silent_p.G34G|IKBKG_uc011mzs.1_Silent_p.G46G|IKBKG_uc004fma.3_RNA|IKBKG_uc004fmc.3_Silent_p.G34G|IKBKG_uc004fmd.2_Silent_p.G46G|IKBKG_uc010nvc.1_Silent_p.G34G|IKBKG_uc010nvd.1_Silent_p.G34G	NM_001099857	NP_001093327	Q9Y6K9	NEMO_HUMAN	inhibitor of kappa light polypeptide gene	46	Interaction with CHUK/IKBKB.				activation of MAPK activity|induction of apoptosis|innate immune response|interspecies interaction between organisms|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	metal ion binding|protein domain specific binding|signal transducer activity				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGAACAGGGCGCTCCTGAGA	0.632			NA							Incontinentia_Pigmenttype_2				46	71					9.58827e-17	1.44399e-16	0.00361	1	0
GAB3	139716	broad.mit.edu	37	X	153927787	153927787	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:153927787G>T	uc004fmj.1	-	6	1172	c.1124C>A	c.(1123-1125)CCA>CAA	p.P375Q	GAB3_uc004fmk.1_Missense_Mutation_p.P376Q|GAB3_uc010nve.1_Missense_Mutation_p.P376Q|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	375										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GAACCTGCATGGCTGCAAAAG	0.522			NA											30	32					5.45727e-16	8.08922e-16	0.008361	1	0
F8	2157	broad.mit.edu	37	X	154065972	154065972	+	Missense_Mutation	SNP	G	G	C	rs137852472		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:154065972G>C	uc004fmt.2	-	26	7127	c.6956C>G	c.(6955-6957)CCG>CGG	p.P2319R	F8_uc004fms.2_Missense_Mutation_p.P184R	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2319	F5/8 type C 2.		P -> L (in HEMA; mild/severe).|P -> S (in HEMA; mild).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AGTCAGTAACGGTGGGTCTAG	0.502			NA											14	37					0	0	0.00245	0	0
F8	2157	broad.mit.edu	37	X	154225253	154225253	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:154225253G>A	uc004fmt.2	-	3	554	c.383C>T	c.(382-384)TCT>TTT	p.S128F	F8_uc011mzx.1_Missense_Mutation_p.S93F	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	128	Plastocyanin-like 1.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CTCACCCTCAGAAGCTTTCCA	0.423			NA											100	168					0	0	0.00361	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525976	176525976	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:176525976delC	uc001gkz.2	+	2	1682	c.518delC	c.(517-519)ACCfs	p.T173fs	PAPPA2_uc001gky.1_Frame_Shift_Del_p.T173fs|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	173	Poly-Thr.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCCACTACTACCACCGCCATT	0.577			NA											55	133	---	---	---	---	NA	NA	NA	NA	NA
USH2A	7399	broad.mit.edu	37	1	216538348	216538348	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:216538348delC	uc001hku.1	-	4	1118	c.731delG	c.(730-732)GGTfs	p.G244fs	USH2A_uc001hkv.2_Frame_Shift_Del_p.G244fs	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	244	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTAATTGAACCACTTAGAGT	0.353			NA								HNSCC(13;0.011)			23	47	---	---	---	---	NA	NA	NA	NA	NA
OR2M1P	388762	broad.mit.edu	37	1	248286052	248286053	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr1:248286052_248286053delGG	uc001idy.1	+	1	615_616	c.615_616delGG	c.(613-618)CTGGTGfs	p.L205fs		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						AGGACAAGCTGGTGTCTGTATT	0.505			NA											49	74	---	---	---	---	NA	NA	NA	NA	NA
MYOF	26509	broad.mit.edu	37	10	95169426	95169426	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr10:95169426delC	uc001kin.2	-	6	627	c.504delG	c.(502-504)GGGfs	p.G168fs	MYOF_uc001kio.2_Frame_Shift_Del_p.G168fs|MYOF_uc001kip.3_Frame_Shift_Del_p.G168fs|MYOF_uc009xuf.2_Frame_Shift_Del_p.G150fs	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	168	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TCCCAACTGGCCCCTTGGGCC	0.542			NA											164	265	---	---	---	---	NA	NA	NA	NA	NA
NELL1	4745	broad.mit.edu	37	11	21555993	21555993	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:21555993delC	uc001mqe.2	+	16	1872	c.1719delC	c.(1717-1719)TACfs	p.Y573fs	NELL1_uc001mqf.2_Intron|NELL1_uc009yid.2_Frame_Shift_Del_p.Y601fs|NELL1_uc010rdo.1_Frame_Shift_Del_p.Y516fs|NELL1_uc010rdp.1_Intron|NELL1_uc001mqh.2_Frame_Shift_Del_p.T183fs	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	573	EGF-like 5; calcium-binding (Potential).			Y -> H (in Ref. 7; AAB06946).	cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						CAGGGTGGTACCACTGTGAGT	0.517			NA											21	67	---	---	---	---	NA	NA	NA	NA	NA
OR5T2	219464	broad.mit.edu	37	11	55999938	55999938	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr11:55999938delC	uc010rjc.1	-	1	724	c.724delG	c.(724-726)GTGfs	p.V242fs		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	242	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATAGAGCCCACAAAGTAGAAG	0.433			NA											60	86	---	---	---	---	NA	NA	NA	NA	NA
DCLK1	9201	broad.mit.edu	37	13	36686012	36686012	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:36686012delC	uc001uvf.2	-	3	950	c.717delG	c.(715-717)GGGfs	p.G239fs		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	239	Doublecortin 2.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TTACCTGTTTCCCATCCAACG	0.483			NA											13	81	---	---	---	---	NA	NA	NA	NA	NA
ZC3H13	23091	broad.mit.edu	37	13	46549613	46549616	+	Frame_Shift_Del	DEL	CTCT	CTCT	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	CTCT	CTCT	-	-	CTCT	CTCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:46549613_46549616delCTCT	uc010tfw.1	-	11	2276_2279	c.2270_2273delAGAG	c.(2269-2274)GAGAGGfs	p.E757fs	ZC3H13_uc001vas.1_Frame_Shift_Del_p.E757fs|ZC3H13_uc001vat.1_Frame_Shift_Del_p.E757fs	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	757_758	Arg/Glu-rich.|Potential.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		ctctctctccctctctctctcttc	0.152	Esophageal Squamous(187;747 2077 11056 31291 44172)		NA											30	33	---	---	---	---	NA	NA	NA	NA	NA
GPC6	10082	broad.mit.edu	37	13	94482692	94482704	+	Frame_Shift_Del	DEL	ACGTGCCCCGGAA	ACGTGCCCCGGAA	-	rs143089233		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	ACGTGCCCCGGAA	ACGTGCCCCGGAA	-	-	ACGTGCCCCGGAA	ACGTGCCCCGGAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr13:94482692_94482704delACGTGCCCCGGAA	uc001vlt.2	+	3	1237_1249	c.605_617delACGTGCCCCGGAA	c.(604-618)GACGTGCCCCGGAAAfs	p.D202fs	GPC6_uc010tig.1_Frame_Shift_Del_p.D202fs|GPC6_uc001vlu.1_Frame_Shift_Del_p.D132fs	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	202_206						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CCATTTGGAGACGTGCCCCGGAAACTGAAGATT	0.502			NA											9	50	---	---	---	---	NA	NA	NA	NA	NA
SYT16	83851	broad.mit.edu	37	14	62567160	62567160	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr14:62567160delC	uc001xfu.1	+	6	1870	c.1673delC	c.(1672-1674)TCCfs	p.S558fs	SYT16_uc010tse.1_Frame_Shift_Del_p.S116fs	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	558	C2 2.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		CAAGAGATGTCCCGTTGCAAG	0.463			NA											32	27	---	---	---	---	NA	NA	NA	NA	NA
PALB2	79728	broad.mit.edu	37	16	23637683	23637683	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr16:23637683delG	uc002dlx.1	-	7	2822	c.2622delC	c.(2620-2622)GCCfs	p.A874fs		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	874	Interaction with RAD51 and BRCA2.|WD 1.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		CCCAAAACATGGCACTCACAT	0.443			NA	F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				22	169	---	---	---	---	NA	NA	NA	NA	NA
MYH1	4619	broad.mit.edu	37	17	10402323	10402323	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr17:10402323delC	uc002gmo.2	-	29	4046	c.3952delG	c.(3952-3954)GAAfs	p.E1318fs	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1318	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CTTTTCAGTTCCTCAATCTGT	0.393			NA											26	85	---	---	---	---	NA	NA	NA	NA	NA
RNMT	8731	broad.mit.edu	37	18	13731472	13731484	+	Splice_Site	DEL	TAGTGTTGGTTCA	TAGTGTTGGTTCA	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	TAGTGTTGGTTCA	TAGTGTTGGTTCA	-	-	TAGTGTTGGTTCA	TAGTGTTGGTTCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr18:13731472_13731484delTAGTGTTGGTTCA	uc002ksk.1	+	2	26	c.-41_splice	c.e2-1		RNMT_uc002ksl.1_Splice_Site|RNMT_uc002ksm.1_Splice_Site|RNMT_uc010dlk.2_Splice_Site|RNMT_uc010xae.1_Intron	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase						mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						TTTCCTATTCTAGTGTTGGTTCATGAAGTTTTA	0.239	GBM(29;474 594 19092 36647 41529)		NA											44	38	---	---	---	---	NA	NA	NA	NA	NA
ADAMTS10	81794	broad.mit.edu	37	19	8656874	8656875	+	Frame_Shift_Ins	INS	-	-	G			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:8656874_8656875insG	uc002mkj.1	-	14	1974_1975	c.1700_1701insC	c.(1699-1701)GTGfs	p.V567fs	ADAMTS10_uc002mki.1_Frame_Shift_Ins_p.C58fs|ADAMTS10_uc002mkk.1_Frame_Shift_Ins_p.V199fs	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	567	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TAGAAGAGGACACGCCGCCGCC	0.723			NA											13	14	---	---	---	---	NA	NA	NA	NA	NA
ZNF100	163227	broad.mit.edu	37	19	21909726	21909726	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:21909726delC	uc002nqi.2	-	5	1587	c.1388delG	c.(1387-1389)GGCfs	p.G463fs	ZNF100_uc002nqh.2_Frame_Shift_Del_p.G399fs	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	463	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGGCTTTGCCACATTCGTC	0.403			NA											20	18	---	---	---	---	NA	NA	NA	NA	NA
CD22	933	broad.mit.edu	37	19	35832490	35832499	+	Frame_Shift_Del	DEL	CTGGACACTT	CTGGACACTT	-	rs141451390		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	CTGGACACTT	CTGGACACTT	-	-	CTGGACACTT	CTGGACACTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr19:35832490_35832499delCTGGACACTT	uc010edt.2	+	8	1829_1838	c.1752_1761delCTGGACACTT	c.(1750-1761)GCCTGGACACTTfs	p.A584fs	CD22_uc010xst.1_Frame_Shift_Del_p.A412fs|CD22_uc010edu.2_Frame_Shift_Del_p.A496fs|CD22_uc010edv.2_Frame_Shift_Del_p.A584fs|CD22_uc002nzb.3_Frame_Shift_Del_p.A407fs|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	584_587	Extracellular (Potential).				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CGTCCAAGGCCTGGACACTTGAAGTGCTGT	0.59	Ovarian(42;1009 1133 23674 26041)		NA											8	124	---	---	---	---	NA	NA	NA	NA	NA
TANC1	85461	broad.mit.edu	37	2	160028721	160028721	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr2:160028721delG	uc002uag.2	+	11	1715	c.1441delG	c.(1441-1443)GGGfs	p.G481fs	TANC1_uc010fol.1_Frame_Shift_Del_p.G375fs|TANC1_uc010zcm.1_Frame_Shift_Del_p.G473fs|TANC1_uc010fom.1_Frame_Shift_Del_p.G287fs	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	481						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AACACCTCTTGGGTCTATCAG	0.453			NA											32	66	---	---	---	---	NA	NA	NA	NA	NA
OSM	5008	broad.mit.edu	37	22	30660280	30660281	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr22:30660280_30660281insT	uc003ahb.2	-	3	402_403	c.350_351insA	c.(349-351)CTCfs	p.L117fs		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	117					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			GGGCCTTGGGGAGGCGCTGCTC	0.629			NA											19	25	---	---	---	---	NA	NA	NA	NA	NA
VILL	50853	broad.mit.edu	37	3	38044020	38044022	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	TCT	TCT	-	-	TCT	TCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:38044020_38044022delTCT	uc003chj.2	+	14	1899_1901	c.1613_1615delTCT	c.(1612-1617)ATCTTC>ATC	p.F539del	VILL_uc003chl.2_In_Frame_Del_p.F539del	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	539	Gelsolin-like 5.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TCCAGTGACATCTTCTTGCTGGT	0.571			NA											20	79	---	---	---	---	NA	NA	NA	NA	NA
SEMA3F	6405	broad.mit.edu	37	3	50225491	50225491	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:50225491delT	uc003cyj.2	+	19	2499	c.2301delT	c.(2299-2301)CCTfs	p.P767fs	SEMA3F_uc003cyk.2_Frame_Shift_Del_p.P736fs	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	767	Arg/Lys-rich (basic).				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CCCGGTCTCCTGAGCCCCAGG	0.687			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
SI	6476	broad.mit.edu	37	3	164758880	164758880	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr3:164758880delA	uc003fei.2	-	18	2069	c.2007delT	c.(2005-2007)CATfs	p.H669fs		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	669	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAGGATCCTGATGCTGTGAGA	0.323			NA								HNSCC(35;0.089)			23	71	---	---	---	---	NA	NA	NA	NA	NA
MUC7	4589	broad.mit.edu	37	4	71347137	71347137	+	Frame_Shift_Del	DEL	C	C	-	rs144213977		TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:71347137delC	uc011cat.1	+	4	964	c.676delC	c.(676-678)CCAfs	p.P226fs	MUC7_uc011cau.1_Frame_Shift_Del_p.P226fs|MUC7_uc003hfj.2_Frame_Shift_Del_p.P226fs|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	226	3.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			ACCAGCTCCACCATCTTCCTC	0.582			NA											82	76	---	---	---	---	NA	NA	NA	NA	NA
FAT4	79633	broad.mit.edu	37	4	126242180	126242181	+	Frame_Shift_Ins	INS	-	-	CCATCAG			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr4:126242180_126242181insCCATCAG	uc003ifj.3	+	1	4614_4615	c.4614_4615insCCATCAG	c.(4612-4617)GACCCAfs	p.D1538fs		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1538_1539	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTGCTGCAGACCCATCAGCTGT	0.436			NA											20	289	---	---	---	---	NA	NA	NA	NA	NA
RAPGEF6	51735	broad.mit.edu	37	5	130799906	130799906	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr5:130799906delC	uc003kvn.1	-	18	2514	c.2308delG	c.(2308-2310)GACfs	p.D770fs	RAPGEF6_uc003kvp.1_Frame_Shift_Del_p.D820fs|RAPGEF6_uc003kvo.1_Frame_Shift_Del_p.D775fs|RAPGEF6_uc010jdi.1_Frame_Shift_Del_p.D770fs|RAPGEF6_uc010jdj.1_Frame_Shift_Del_p.D770fs|RAPGEF6_uc003kvq.2_Frame_Shift_Del_p.D487fs|RAPGEF6_uc003kvr.2_Frame_Shift_Del_p.D770fs|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Frame_Shift_Del_p.D770fs	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	770	Ras-associating.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		GCTGTGGTGTCTTTACTGATG	0.353	Melanoma(168;435 1955 13113 13877 23213)		NA											28	37	---	---	---	---	NA	NA	NA	NA	NA
IL22RA2	116379	broad.mit.edu	37	6	137479601	137479602	+	Frame_Shift_Ins	INS	-	-	C			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr6:137479601_137479602insC	uc003qhl.2	-	3	380_381	c.79_80insG	c.(79-81)GAGfs	p.E27fs	IL22RA2_uc003qhm.2_Frame_Shift_Ins_p.E27fs|IL22RA2_uc003qhn.2_Frame_Shift_Ins_p.E27fs	NM_052962	NP_443194	Q969J5	I22R2_HUMAN	interleukin 22-binding protein isoform 1	27	Fibronectin type-III 1.				regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	interleukin-22 receptor activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000313)|OV - Ovarian serous cystadenocarcinoma(155;0.00407)		CTTCAGAGACTCATGCGTTGAC	0.46			NA											30	112	---	---	---	---	NA	NA	NA	NA	NA
ARPC1A	10552	broad.mit.edu	37	7	98963515	98963515	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:98963515delC	uc003upx.1	+	10	1223	c.1076delC	c.(1075-1077)ACCfs	p.T359fs	ARPC1A_uc010lfu.1_RNA|ARPC1A_uc003upy.1_Frame_Shift_Del_p.T345fs|ARPC1A_uc011kit.1_Intron	NM_006409	NP_006400	Q92747	ARC1A_HUMAN	actin related protein 2/3 complex subunit 1A	359	WD 6.				actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			TTTTCCAAGACCCTCGAGTCT	0.577			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
LRGUK	136332	broad.mit.edu	37	7	133812369	133812370	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr7:133812369_133812370insT	uc003vrm.1	+	1	265_266	c.249_250insT	c.(247-252)GGCGAGfs	p.G83fs		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	83_84							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						AGGGCGAGGGCGAGGCGGGATC	0.614			NA											41	74	---	---	---	---	NA	NA	NA	NA	NA
TMEM64	169200	broad.mit.edu	37	8	91643913	91643913	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr8:91643913delT	uc003yen.2	-	2	818	c.818delA	c.(817-819)AACfs	p.N273fs	TMEM64_uc003yeo.2_Frame_Shift_Del_p.N12fs|TMEM64_uc011lgf.1_Intron	NM_001008495	NP_001008495	Q6YI46	TMM64_HUMAN	transmembrane protein 64 isoform 1	273						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(11;0.0598)			CATCAGATAGTTGGGTAATGA	0.383			NA											9	192	---	---	---	---	NA	NA	NA	NA	NA
NTRK2	4915	broad.mit.edu	37	9	87342645	87342645	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:87342645delC	uc004aoa.1	+	11	1868	c.930delC	c.(928-930)AACfs	p.N310fs	NTRK2_uc004anv.1_Frame_Shift_Del_p.N297fs|NTRK2_uc004any.1_Frame_Shift_Del_p.N310fs|NTRK2_uc004anz.1_Frame_Shift_Del_p.N310fs|NTRK2_uc011lsz.1_Frame_Shift_Del_p.N310fs|NTRK2_uc011lta.1_Frame_Shift_Del_p.N310fs|NTRK2_uc004aob.1_Frame_Shift_Del_p.N310fs|NTRK2_uc011ltb.1_Frame_Shift_Del_p.N154fs	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	310	Extracellular (Potential).|Ig-like C2-type 2.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TGAAAGGCAACCCCAAACCAG	0.423			NA								TSP Lung(25;0.17)			12	42	---	---	---	---	NA	NA	NA	NA	NA
C9orf125	84302	broad.mit.edu	37	9	104238293	104238293	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chr9:104238293delC	uc004bbm.2	-	2	1404	c.1082delG	c.(1081-1083)GGCfs	p.G361fs	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	361						integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				CATGTCCTTGCCAAAGCCCTT	0.612			NA											11	22	---	---	---	---	NA	NA	NA	NA	NA
MAGEB2	4113	broad.mit.edu	37	X	30237448	30237448	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:30237448delG	uc004dbz.2	+	2	854	c.751delG	c.(751-753)GATfs	p.D251fs		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	251	MAGE.						protein binding			ovary(1)	1						CATCACCAAAGATCTGGTGCA	0.507			NA											19	38	---	---	---	---	NA	NA	NA	NA	NA
KDM5C	8242	broad.mit.edu	37	X	53245063	53245063	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4390-01A-02D-1753-08	TCGA-05-4390-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d0854b5b-69be-4b84-aa37-ecdd0bc14de9	b9b0fda8-ff98-4d0b-905d-38d9464cd3ab	g.chrX:53245063delC	uc004drz.2	-	7	1410	c.877delG	c.(877-879)GAGfs	p.E293fs	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Frame_Shift_Del_p.E226fs|KDM5C_uc004dsa.2_Frame_Shift_Del_p.E292fs	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	293					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						TCCTTGCTCTCCAGGAAGGTC	0.572			NA	N|F|S		clear cell renal carcinoma								36	70	---	---	---	---	NA	NA	NA	NA	NA
