Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAL1	6886	broad.mit.edu	37	1	47685806	47685806	+	Silent	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr1:47685806G>A	uc001cqx.2	-	4	1159	c.582C>T	c.(580-582)AGC>AGT	p.S194S	TAL1_uc009vyq.2_5'UTR|TAL1_uc001cqy.2_Silent_p.S194S	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	194	Basic motif.				basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						ATCGCTCCCGGCTGTTGGTGA	0.562			NA	T	TRD@|SIL	lymphoblastic leukemia/biphasic								18	24					0	0	0.007413	0	0
RAG1AP1	55974	broad.mit.edu	37	1	155108457	155108457	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr1:155108457T>G	uc001fhj.3	+	1	170	c.70T>G	c.(70-72)TCC>GCC	p.S24A	RAG1AP1_uc010pey.1_RNA|RAG1AP1_uc001fhk.3_Missense_Mutation_p.L10R|RAG1AP1_uc001fhl.3_Missense_Mutation_p.S24A	NM_018845	NP_061333	Q9BRV3	SWET1_HUMAN	recombination activating gene 1 activating	24	MtN3/slv 1.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGCATGTTCTCCGCCGGCCT	0.642			NA											9	37					0	0	0.010729	0	0
KDM5B	10765	broad.mit.edu	37	1	202699065	202699065	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr1:202699065G>C	uc001gyf.2	-	26	4383	c.4267C>G	c.(4267-4269)CGG>GGG	p.R1423G	KDM5B_uc009xag.2_Missense_Mutation_p.R1459G|KDM5B_uc001gyg.1_Missense_Mutation_p.R1265G	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1423					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CGTTCCCACCGCTCACTGGAG	0.483			NA											41	116					0	0	0.005524	0	0
USH2A	7399	broad.mit.edu	37	1	215823979	215823979	+	Silent	SNP	A	A	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr1:215823979A>G	uc001hku.1	-	65	14685	c.14298T>C	c.(14296-14298)AGT>AGC	p.S4766S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4766	Fibronectin type-III 33.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCCTGTAGAGACTGACGATCC	0.532			NA								HNSCC(13;0.011)			28	82					0	0	0.007291	0	0
UPF2	26019	broad.mit.edu	37	10	11973641	11973641	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr10:11973641T>A	uc001ila.2	-	19	4161	c.3687A>T	c.(3685-3687)CAA>CAT	p.Q1229H	UPF2_uc001ilb.2_Missense_Mutation_p.Q1229H|UPF2_uc001ilc.2_Missense_Mutation_p.Q1229H	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	1229	Sufficient for interaction with UPF1 C- terminus.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				ATTTTATACCTTGATAATCTT	0.338			NA											36	75					0	0	0.004878	0	0
HMX2	3167	broad.mit.edu	37	10	124907981	124907981	+	Silent	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr10:124907981C>T	uc001lhc.1	+	1	344	c.87C>T	c.(85-87)GGC>GGT	p.G29G		NM_005519	NP_005510	A2RU54	HMX2_HUMAN	H6 family homeobox 2	29					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.169)|Colorectal(57;0.207)|Glioma(114;0.222)		Colorectal(40;0.123)|COAD - Colon adenocarcinoma(40;0.141)		TGGGCGGGGGCCCCTCGGAGG	0.701			NA											18	30					0	0	0.010504	0	0
C10orf137	26098	broad.mit.edu	37	10	127426974	127426974	+	Silent	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr10:127426974C>T	uc001liq.1	+	15	2234	c.1941C>T	c.(1939-1941)CCC>CCT	p.P647P	C10orf137_uc001lin.2_Silent_p.P613P|C10orf137_uc001lio.1_Silent_p.P613P|C10orf137_uc001lip.1_Silent_p.P351P|C10orf137_uc001lir.2_Silent_p.P141P|C10orf137_uc001lis.1_5'Flank	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	647					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GAGGGGGTCCCGAGGGGCTAG	0.438			NA											18	98					0	0	0.006122	0	0
OR8H1	219469	broad.mit.edu	37	11	56058356	56058356	+	Silent	SNP	A	A	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr11:56058356A>G	uc010rje.1	-	1	183	c.183T>C	c.(181-183)TTT>TTC	p.F61F		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GAGTAAGGAAAAAATACATGG	0.393			NA											83	142					0	0	0.01441	0	0
NDUFV1	4723	broad.mit.edu	37	11	67378532	67378532	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr11:67378532G>A	uc001omj.2	+	6	920	c.767G>A	c.(766-768)CGC>CAC	p.R256H	NDUFV1_uc010rpv.1_Missense_Mutation_p.R155H|NDUFV1_uc001oml.2_Missense_Mutation_p.R249H|NDUFV1_uc001omk.3_Missense_Mutation_p.R247H|NDUFV1_uc009yrz.1_Missense_Mutation_p.R155H|NDUFV1_uc010rpw.1_5'UTR	NM_007103	NP_009034	P49821	NDUV1_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 1	256					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	ACAATCTGCCGCCGTGGAGGT	0.562			NA											18	64					0	0	0.006122	0	0
SIK2	23235	broad.mit.edu	37	11	111591374	111591374	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr11:111591374A>T	uc001plt.2	+	11	1786	c.1668A>T	c.(1666-1668)AGA>AGT	p.R556S		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	556					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						TAAGCCTGAGACCTACCAACC	0.537			NA											40	81					0	0	0.00874	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			15	17					3.41278e-10	4.4905e-10	0.00499	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43837660	43837660	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr12:43837660C>T	uc010skx.1	-	16	2224	c.2224G>A	c.(2224-2226)GCA>ACA	p.A742T		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	742	Spacer.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTTGCTCCTGCGGGAATCTTT	0.383			NA											64	173					0	0	0.01441	0	0
SLC11A2	4891	broad.mit.edu	37	12	51393019	51393019	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr12:51393019G>A	uc001rxe.3	-	8	710	c.613C>T	c.(613-615)CGG>TGG	p.R205W	SLC11A2_uc001rxd.3_Missense_Mutation_p.R54W|SLC11A2_uc001rxc.3_Missense_Mutation_p.R205W|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc010smx.1_Missense_Mutation_p.R201W|SLC11A2_uc001rxh.1_Missense_Mutation_p.R205W|SLC11A2_uc001rxj.1_Missense_Mutation_p.R205W|SLC11A2_uc001rxi.2_Missense_Mutation_p.R205W|SLC11A2_uc001rxk.1_Missense_Mutation_p.R234W|SLC11A2_uc010smy.1_Missense_Mutation_p.R168W	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	205	Cytoplasmic (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						TCTAGCTTCCGCAAGCCTAAA	0.453			NA											4	85					0	0	0.009096	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453707	84453707	+	Silent	SNP	G	G	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr13:84453707G>T	uc001vlk.2	-	1	2822	c.1936C>A	c.(1936-1938)CGA>AGA	p.R646R		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	646	Cytoplasmic (Potential).					integral to membrane		p.R646*(1)		ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GACCGCTTTCGGTTCCTCAGG	0.562			NA											15	35					6.31663e-08	7.89578e-08	0.003163	1	0
COL4A2	1284	broad.mit.edu	37	13	111154090	111154090	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr13:111154090C>T	uc001vqx.2	+	41	4125	c.3836C>T	c.(3835-3837)GCA>GTA	p.A1279V		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1279	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			ATCTCTGGGGCACCTGGTGAC	0.547			NA											13	42					0	0	0.00499	0	0
NEDD8	4738	broad.mit.edu	37	14	24687421	24687421	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr14:24687421C>T	uc001wnn.2	-	3	170	c.67G>A	c.(67-69)GTG>ATG	p.V23M	CHMP4A_uc001wnj.2_5'Flank|MDP1_uc001wnk.1_5'Flank|CHMP4A_uc001wnm.1_5'Flank|MDP1_uc001wnl.1_5'Flank|NEDD8_uc001wno.2_RNA	NM_006156	NP_006147	Q15843	NEDD8_HUMAN	neural precursor cell expressed, developmentally	23					anatomical structure morphogenesis|protein neddylation|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin protein ligase binding				0				GBM - Glioblastoma multiforme(265;0.0186)		ATTCGCTCCACCTTTAGAGAG	0.517			NA											23	62					0	0	0.014323	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40284374	40284374	+	Splice_Site	SNP	A	A	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr15:40284374A>G	uc001zkm.1	+	17	2682	c.2632_splice	c.e17-2	p.A878_splice	EIF2AK4_uc010bbj.1_Splice_Site_p.A579_splice|EIF2AK4_uc001zkn.1_5'UTR	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha						translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TTATATTTTTAGGCTGACAGC	0.353			NA											3	73					0	0	0.004672	0	0
DUOX2	50506	broad.mit.edu	37	15	45405197	45405197	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr15:45405197G>A	uc010bea.2	-	3	351	c.148C>T	c.(148-150)CGT>TGT	p.R50C	DUOX2_uc001zun.2_Missense_Mutation_p.R50C|DUOXA2_uc001zuo.2_5'Flank|DUOXA2_uc010beb.2_5'Flank	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	50	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ACAGCACCACGCTCGTGGTGC	0.677			NA											15	42					0	0	0.004007	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65208038	65208038	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr15:65208038A>G	uc002aoa.2	+	2	106	c.77A>G	c.(76-78)AAC>AGC	p.N26S	ANKDD1A_uc002anx.1_Missense_Mutation_p.N26S|ANKDD1A_uc002any.2_5'UTR|ANKDD1A_uc002anz.2_Intron|ANKDD1A_uc002aob.2_5'UTR	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	26	ANK 1.				signal transduction					ovary(1)	1						GCCCGCCAGAACAATGTCGGC	0.597			NA											12	41					0	0	0.010729	0	0
MEX3B	84206	broad.mit.edu	37	15	82336228	82336228	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr15:82336228G>A	uc002bgq.1	-	2	1298	c.983C>T	c.(982-984)GCG>GTG	p.A328V		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	328					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						TCCGTTGTGCGCAAAGCTCAG	0.647			NA											33	86					0	0	0.004878	0	0
PCSK6	5046	broad.mit.edu	37	15	101971641	101971641	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr15:101971641G>A	uc002bwy.2	-	5	855	c.541C>T	c.(541-543)CGG>TGG	p.R181W	PCSK6_uc010bpd.2_Missense_Mutation_p.R51W|PCSK6_uc010bpe.2_Missense_Mutation_p.R181W|PCSK6_uc002bxa.2_Missense_Mutation_p.R181W|PCSK6_uc002bxb.2_Missense_Mutation_p.R181W|PCSK6_uc002bxc.1_Missense_Mutation_p.R181W|PCSK6_uc002bxd.1_Missense_Mutation_p.R181W|PCSK6_uc002bxe.2_Missense_Mutation_p.R181W|PCSK6_uc002bxg.1_Missense_Mutation_p.R181W	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	181	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATTTCCGACCGGCAGCGACTG	0.527			NA											11	18					0	0	0.010729	0	0
MEFV	4210	broad.mit.edu	37	16	3304666	3304666	+	Silent	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr16:3304666C>T	uc002cun.1	-	2	442	c.402G>A	c.(400-402)CCG>CCA	p.P134P		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	134					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	CGCCCCCGTACGGCCGAGGGC	0.697			NA											11	28					0	0	0.010729	0	0
UBN1	29855	broad.mit.edu	37	16	4920917	4920917	+	Silent	SNP	A	A	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr16:4920917A>G	uc002cyb.2	+	11	1842	c.1503A>G	c.(1501-1503)AAA>AAG	p.K501K	UBN1_uc010uxw.1_Silent_p.K501K|UBN1_uc002cyc.2_Silent_p.K501K	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	501	Potential.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						ATGAAGAAAAAGGGGGCAGGA	0.522			NA											3	61					0	0	0.004672	0	0
UBFD1	56061	broad.mit.edu	37	16	23569456	23569456	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr16:23569456G>A	uc002dlv.2	+	2	413	c.211G>A	c.(211-213)GTC>ATC	p.V71I	EARS2_uc002dls.3_5'Flank|EARS2_uc002dlt.3_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	71											0				GBM - Glioblastoma multiforme(48;0.0331)		CCAGGCCTCGGTCAGCAACGG	0.622	Melanoma(22;290 1069 22358 48158)		NA											18	29					0	0	0.008871	0	0
PRMT7	54496	broad.mit.edu	37	16	68389759	68389759	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr16:68389759G>A	uc002evy.1	+	17	2060	c.1784G>A	c.(1783-1785)TGT>TAT	p.C595Y	PRMT7_uc010vlg.1_Missense_Mutation_p.C545Y|PRMT7_uc002evz.1_Missense_Mutation_p.C367Y|PRMT7_uc010cfd.1_Missense_Mutation_p.C87Y	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	595					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CAGCCCCTGTGTGCCGAGGGC	0.687			NA											7	19					0	0	0.001984	0	0
DSG4	147409	broad.mit.edu	37	18	28991295	28991295	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr18:28991295G>A	uc002kwq.2	+	15	2374	c.2239G>A	c.(2239-2241)GCA>ACA	p.A747T	DSG4_uc002kwr.2_Missense_Mutation_p.A766T	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	747	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCTCATggccgcaggggccgc	0.473			NA											4	67					0	0	0.009096	0	0
ZNF536	9745	broad.mit.edu	37	19	30935693	30935693	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr19:30935693C>A	uc002nsu.1	+	2	1362	c.1224C>A	c.(1222-1224)GAC>GAA	p.D408E	ZNF536_uc010edd.1_Missense_Mutation_p.D408E	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCCCCAGCGACCCCGAGGTGC	0.632			NA											14	56					1.05317e-09	1.36186e-09	0.00245	1	0
CYP2A6	1548	broad.mit.edu	37	19	41351918	41351918	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr19:41351918C>T	uc002opl.3	-	6	937	c.916G>A	c.(916-918)GTC>ATC	p.V306I	CYP2A6_uc010ehe.1_Missense_Mutation_p.V102I|CYP2A6_uc010ehf.1_RNA	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	306					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	GTGGTGCTGACGGTCTCGGTG	0.597			NA											27	63					0	0	0.00632	0	0
Unknown	0	broad.mit.edu	37	2	96521777	96521777	+	Missense_Mutation	SNP	T	T	C	rs77768218		TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr2:96521777T>C	uc002suz.1	-	31	2790	c.1313A>G	c.(1312-1314)CAT>CGT	p.H438R						SubName: Full=Putative uncharacterized protein ENSP00000312008; Flags: Fragment;												NA						AAGGTCTTCATGCTTTCTTTT	0.383			NA											3	48					0	0	0.009096	0	0
GPR45	11250	broad.mit.edu	37	2	105859409	105859409	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr2:105859409G>A	uc002tco.1	+	1	1210	c.1094G>A	c.(1093-1095)TGC>TAC	p.C365Y		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	365	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GTCTACGTGTGCAATGAAAAC	0.602			NA											30	81					0	0	0.008361	0	0
PLCL1	5334	broad.mit.edu	37	2	198950357	198950357	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr2:198950357T>G	uc010fsp.2	+	2	2407	c.2116T>G	c.(2116-2118)TAC>GAC	p.Y706D	PLCL1_uc002uuv.3_Missense_Mutation_p.Y627D	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	706					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TGAAGTTTCTTACTTCAGCGC	0.483			NA											60	114					0	0	0.01441	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374365	31374365	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr20:31374365C>T	uc002wyc.2	+	5	685	c.364C>T	c.(364-366)CGT>TGT	p.R122C	DNMT3B_uc010ztx.1_Intron|DNMT3B_uc010zty.1_Intron|DNMT3B_uc002wyd.2_Missense_Mutation_p.R122C|DNMT3B_uc002wye.2_Missense_Mutation_p.R122C|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Intron|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Missense_Mutation_p.R134C	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	122	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						GCCTTCCCCACGTTCCACCCG	0.632			NA											16	58					0	0	0.006122	0	0
MYH7B	57644	broad.mit.edu	37	20	33570262	33570262	+	Silent	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr20:33570262C>T	uc002xbi.1	+	8	746	c.654C>T	c.(652-654)ACC>ACT	p.T218T		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	176	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GTCGTCCAAGCGGAGAGTCGG	0.602			NA											8	26					0	0	0.004482	0	0
MORC3	23515	broad.mit.edu	37	21	37741350	37741350	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr21:37741350C>G	uc002yvi.2	+	15	1760	c.1684C>G	c.(1684-1686)CAG>GAG	p.Q562E		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	562					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						ATTGAGTAGTCAGTTTGAAAA	0.323			NA											3	39					0	0	0.004672	0	0
XRN1	54464	broad.mit.edu	37	3	142137373	142137373	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr3:142137373G>A	uc003eus.2	-	12	1386	c.1319C>T	c.(1318-1320)ACG>ATG	p.T440M	XRN1_uc003eut.2_Missense_Mutation_p.T440M|XRN1_uc003euu.2_Missense_Mutation_p.T440M|XRN1_uc003euv.1_Missense_Mutation_p.T301M|XRN1_uc003euw.2_Missense_Mutation_p.T440M|XRN1_uc011bnh.1_Missense_Mutation_p.T230M	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	440					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CCCCATCTTCGTCATGTAATA	0.299			NA											14	52					0	0	0.004007	0	0
SDHAP1	255812	broad.mit.edu	37	3	195701331	195701331	+	Missense_Mutation	SNP	G	G	A	rs78212497	by1000genomes	TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr3:195701331G>A	uc011btq.1	-	8	1162	c.533C>T	c.(532-534)TCG>TTG	p.S178L	SDHAP1_uc003fvx.3_RNA|SDHAP1_uc011btp.1_RNA					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GTCCAATAGCGAGTTTGCCCC	0.592	Ovarian(67;1158 1227 12109 20189 43170)		NA											9	54					0	0	0.006214	0	0
CXCL6	6372	broad.mit.edu	37	4	74702790	74702790	+	Silent	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr4:74702790G>A	uc003hhf.2	+	2	414	c.219G>A	c.(217-219)CCG>CCA	p.P73P	IL8_uc011cbh.1_Intron	NM_002993	NP_002984	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6 (granulocyte	73					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CCGCAGGCCCGCAGTGCTCCA	0.542			NA											4	76					0	0	0.009096	0	0
NAA11	84779	broad.mit.edu	37	4	80246366	80246366	+	Silent	SNP	T	T	C			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr4:80246366T>C	uc003hlt.3	-	1	806	c.666A>G	c.(664-666)TCA>TCG	p.S222S		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	222						cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						CCGAGCTTTCTGAGCTGTCCT	0.537			NA											6	24					0	0	0.001168	0	0
DKK2	27123	broad.mit.edu	37	4	107846995	107846995	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr4:107846995G>A	uc003hyi.2	-	2	1039	c.334C>T	c.(334-336)CGA>TGA	p.R112*	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Nonsense_Mutation_p.R112*	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	112	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space		p.R112G(1)		ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		ATGCCATCTCGGTGGCAGCGC	0.493			NA											8	209					0	0	0.006214	0	0
METTL14	57721	broad.mit.edu	37	4	119626806	119626806	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr4:119626806G>T	uc003icf.2	+	10	1012	c.896G>T	c.(895-897)AGC>ATC	p.S299I	METTL14_uc003icg.2_Missense_Mutation_p.S261I	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	299						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						GTGAAGCGTAGCACAGACGGG	0.373			NA											21	95					2.21704e-12	2.96924e-12	0.00278	1	0
TUBB4Q	56604	broad.mit.edu	37	4	190903839	190903839	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr4:190903839C>A	uc011clg.1	-	4	1144	c.1141G>T	c.(1141-1143)GAG>TAG	p.E381*		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	382					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		GTAAACTGCTCTGAGACCCGC	0.547			NA											6	171					4.096e-09	5.20678e-09	0.001168	1	0
FSTL4	23105	broad.mit.edu	37	5	132736615	132736615	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr5:132736615C>T	uc003kyn.1	-	4	442	c.224G>A	c.(223-225)CGG>CAG	p.R75Q		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	75						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAGCACGCACCGGCTCCCTCG	0.612			NA											16	45					0	0	0.004007	0	0
NRN1	51299	broad.mit.edu	37	6	6006965	6006965	+	Silent	SNP	G	G	A	rs144443923		TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr6:6006965G>A	uc003mwu.2	-	1	669	c.18C>T	c.(16-18)AAC>AAT	p.N6N	NRN1_uc003mwt.2_5'Flank	NM_016588	NP_057672	Q9NPD7	NRN1_HUMAN	neuritin precursor	6						anchored to membrane|plasma membrane					0	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		TATATCTGCCGTTCAACTTAA	0.542			NA											34	119					0	0	0.003755	0	0
NUP43	348995	broad.mit.edu	37	6	150057671	150057671	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr6:150057671C>A	uc003qmz.2	-	6	783	c.726G>T	c.(724-726)TTG>TTT	p.L242F	NUP43_uc003qmx.3_RNA|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Intron	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	242	WD 5.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		CCCAAATACTCAACATTCCAT	0.443			NA											20	61					1.2644e-06	1.5546e-06	0.010504	1	0
CHST12	55501	broad.mit.edu	37	7	2472309	2472309	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr7:2472309T>G	uc003smc.2	+	2	170	c.35T>G	c.(34-36)GTG>GGG	p.V12G	CHST12_uc003smd.2_Missense_Mutation_p.V12G	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	12	Helical; Signal-anchor for type II membrane protein; (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CTGTGGCTGGTGCTGGGGTCG	0.662			NA											6	47					0	0	0.008291	0	0
CLVS1	157807	broad.mit.edu	37	8	62371045	62371045	+	Silent	SNP	C	C	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr8:62371045C>T	uc003xuh.2	+	5	1245	c.921C>T	c.(919-921)CAC>CAT	p.H307H	CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Intron	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	307					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						ATGCAATGCACGTGAAGCATA	0.512			NA											18	61					0	0	0.007413	0	0
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	C	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961	Q9BRT8	CBWD1_HUMAN	COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCACTGCACCTGAAAATATA	0.269			NA											5	202					0	0	0.001168	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971111	21971111	+	Missense_Mutation	SNP	G	G	A	rs121913385		TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr9:21971111G>A	uc003zpk.2	-	2	459	c.247C>T	c.(247-249)CAC>TAC	p.H83Y	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.A138V	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	83	ANK 3.		H -> N (in a lung tumor).|H -> Y (in a pancreas and a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.H83Y(28)|p.?(13)|p.H83fs*2(2)|p.H83P(2)|p.H83N(1)|p.V82fs*62(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.A138V(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.H83R(1)|p.H83Q(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGCGTCGTGCACGGGTCGG	0.741		H83Y(CALU3_LUNG)|H83Y(JHH2_LIVER)|H83Y(HS944T_SKIN)|H83Y(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|H83Y(OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	8					0	0	0.006214	0	0
FBXO10	26267	broad.mit.edu	37	9	37541372	37541372	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr9:37541372C>G	uc004aab.2	-	2	443	c.394G>C	c.(394-396)GAC>CAC	p.D132H	FBXO10_uc004aac.2_Missense_Mutation_p.D148H|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	132						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		ACAATTCGGTCATACAGGCTG	0.567			NA											34	109					0	0	0.012213	0	0
FAM75A2	642265	broad.mit.edu	37	9	39361018	39361018	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr9:39361018G>A	uc004abm.2	+	4	3285	c.3256G>A	c.(3256-3258)GAG>AAG	p.E1086K		NM_001040065	NP_001035154	Q5RGS2	F75A2_HUMAN	hypothetical protein LOC642265	1086						integral to membrane					0				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACTGGTGCACGAGGAGCCCAG	0.542			NA											102	447					0	0	0.01441	0	0
KIAA0913	23053	broad.mit.edu	37	10	75550806	75550807	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr10:75550806_75550807insT	uc009xrl.2	+	8	1047_1048	c.1015_1016insT	c.(1015-1017)CTGfs	p.L339fs	KIAA0913_uc001jve.2_Frame_Shift_Ins_p.L339fs|KIAA0913_uc001jvf.2_Frame_Shift_Ins_p.L339fs|KIAA0913_uc001jvh.2_5'Flank|KIAA0913_uc001jvi.2_5'Flank|KIAA0913_uc010qkr.1_5'Flank|KIAA0913_uc001jvj.2_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	339							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GCTGCGCCCTCTGAGGGGCCGT	0.569			NA											35	85	---	---	---	---	NA	NA	NA	NA	NA
SLC7A6	9057	broad.mit.edu	37	16	68330539	68330539	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr16:68330539delT	uc002evt.1	+	11	1588	c.1279delT	c.(1279-1281)TTTfs	p.F427fs	SLC7A6_uc002evu.1_Frame_Shift_Del_p.F427fs|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	427	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		GCTGAGCGTGTTTTTCCCCAT	0.522			NA											8	382	---	---	---	---	NA	NA	NA	NA	NA
JAG1	182	broad.mit.edu	37	20	10637059	10637060	+	Frame_Shift_Ins	INS	-	-	GA	rs34271232		TCGA-05-4433-01A-22D-1855-08	TCGA-05-4433-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fab4f1ca-1605-4c30-8b3e-badb44eb6580	b4ea29e6-c7ca-4290-8efd-9bdb823edbee	g.chr20:10637059_10637060insGA	uc002wnw.2	-	5	1257_1258	c.741_742insTC	c.(739-744)CTCCCAfs	p.L247fs		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	247_248	Extracellular (Potential).|EGF-like 1.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						CAGTCACCTGGGAGTTTGCAAG	0.441			NA							Alagille_Syndrome				22	71	---	---	---	---	NA	NA	NA	NA	NA
