Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CSF3R	1441	broad.mit.edu	37	1	36932904	36932904	+	Missense_Mutation	SNP	T	T	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:36932904T>C	uc001caw.1	-	16	2145	c.1967A>G	c.(1966-1968)AAT>AGT	p.N656S	MRPS15_uc001cas.2_5'Flank|CSF3R_uc001cat.1_Missense_Mutation_p.N218S|CSF3R_uc009vvc.1_Missense_Mutation_p.N185S|CSF3R_uc001cau.1_Missense_Mutation_p.N56S|CSF3R_uc001cav.1_Missense_Mutation_p.N656S|CSF3R_uc001cax.1_Missense_Mutation_p.N656S|CSF3R_uc001cay.1_Missense_Mutation_p.I625V	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	656	Cytoplasmic (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CCAGAGGGGATTCTTCCTGCT	0.592			NA											54	67					0	0	0.048971	0	0
CFH	3075	broad.mit.edu	37	1	196706690	196706690	+	Silent	SNP	G	G	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:196706690G>C	uc001gtj.3	+	17	2922	c.2682G>C	c.(2680-2682)GGG>GGC	p.G894G		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	894	Sushi 15.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						ATGCACATGGGACTAAATTGA	0.383			NA											14	18					0	0	0.105934	0	0
TRIM58	25893	broad.mit.edu	37	1	248039632	248039632	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:248039632C>G	uc001ido.2	+	6	1350	c.1302C>G	c.(1300-1302)TAC>TAG	p.Y434*	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	434	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTTATATCTACACATTCAACC	0.433			NA											87	122					0	0	0.048971	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430990	37430990	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr10:37430990G>T	uc001iza.1	+	7	1096	c.997G>T	c.(997-999)GAA>TAA	p.E333*		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	389						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GGAGAAAAAAGAAGACACACC	0.428			NA											14	33					1.52009e-12	1.83678e-12	0.024245	1	0
GRID1	2894	broad.mit.edu	37	10	87487669	87487669	+	Silent	SNP	G	G	A	rs149876378		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr10:87487669G>A	uc001kdl.1	-	10	1577	c.1476C>T	c.(1474-1476)TAC>TAT	p.Y492Y	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.Y63Y	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	492	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GCTGGTGACCGTACCTGCCAT	0.557			NA								Multiple Myeloma(13;0.14)			23	53					0	0	0.099896	0	0
GRID1	2894	broad.mit.edu	37	10	87487760	87487760	+	Missense_Mutation	SNP	C	C	T	rs149107262		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr10:87487760C>T	uc001kdl.1	-	10	1486	c.1385G>A	c.(1384-1386)CGC>CAC	p.R462H	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.R33H	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	462	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CCCTTTGTAGCGCTTGGGCTG	0.488			NA								Multiple Myeloma(13;0.14)			11	100					0	0	0.080935	0	0
NAT10	55226	broad.mit.edu	37	11	34153690	34153690	+	Silent	SNP	T	T	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:34153690T>C	uc001mvk.2	+	15	1783	c.1539T>C	c.(1537-1539)GAT>GAC	p.D513D	NAT10_uc010ren.1_Silent_p.D441D	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	513						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				TTAATAGAGATACCCTCTTTT	0.458			NA											52	298					0	0	0.048971	0	0
EHF	26298	broad.mit.edu	37	11	34668230	34668230	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:34668230C>G	uc001mvr.1	+	3	453	c.342C>G	c.(340-342)AAC>AAG	p.N114K	EHF_uc009yke.1_Missense_Mutation_p.N114K|EHF_uc009ykf.1_Missense_Mutation_p.N117K	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	114	PNT.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TGAAGTGGAACGGTGACTCTC	0.557			NA											26	107					0	0	0.037714	0	0
ALX4	60529	broad.mit.edu	37	11	44297153	44297153	+	Silent	SNP	C	C	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:44297153C>A	uc001myb.2	-	2	626	c.522G>T	c.(520-522)GGG>GGT	p.G174G		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	174					hair follicle development						0						TGCTGTCCATCCCCACAGTGT	0.587			NA											34	52					1.22384e-17	1.51027e-17	0.054565	1	0
TMX2	51075	broad.mit.edu	37	11	57480103	57480103	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:57480103G>C	uc001nlc.1	+	1	62	c.13G>C	c.(13-15)GCA>CCA	p.A5P	CTNND1_uc001nlf.1_5'UTR|MED19_uc001nla.1_5'Flank|MED19_uc001nlb.2_5'Flank|TMX2_uc001nld.1_5'UTR|TMX2_uc001nle.1_Missense_Mutation_p.A5P	NM_015959	NP_057043	Q9Y320	TMX2_HUMAN	thioredoxin domain containing 14 isoform 1	5					cell redox homeostasis	integral to membrane					0						GGCGGTCTTGGCACCTCTAAT	0.597			NA											5	15					0	0	0.021553	0	0
CD163L1	283316	broad.mit.edu	37	12	7526177	7526177	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:7526177C>G	uc001qsy.2	-	14	3495	c.3469G>C	c.(3469-3471)GAA>CAA	p.E1157Q	CD163L1_uc010sge.1_Missense_Mutation_p.E1167Q	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1157	SRCR 11.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TAGAAGACTTCCAATCTCCCA	0.488			NA											20	135					0	0	0.0918	0	0
KRT7	3855	broad.mit.edu	37	12	52639248	52639248	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:52639248C>T	uc001saa.1	+	7	1164	c.1037C>T	c.(1036-1038)GCG>GTG	p.A346V	KRT7_uc009zmf.1_Intron	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	346	Rod.|Coil 2.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		GGGGAGCTGGCGCTCAAGGAT	0.647			NA											6	23					0	0	0.02938	0	0
C12orf48	55010	broad.mit.edu	37	12	102569349	102569349	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:102569349G>A	uc001tjf.2	+	7	1022	c.910G>A	c.(910-912)GAA>AAA	p.E304K	C12orf48_uc001tjg.2_Missense_Mutation_p.E223K|C12orf48_uc010swa.1_Missense_Mutation_p.E381K|C12orf48_uc001tjh.2_Missense_Mutation_p.E223K|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.E19K|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	304					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						AGCAATAGAGGAAGTTGCTCA	0.398			NA											23	37					0	0	0.083992	0	0
NCOR2	9612	broad.mit.edu	37	12	124840077	124840077	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:124840077G>A	uc010tba.1	-	24	3423	c.3306C>T	c.(3304-3306)CCC>CCT	p.P1102P	NCOR2_uc010tay.1_Silent_p.P1101P|NCOR2_uc010taz.1_Silent_p.P1085P|NCOR2_uc010tbb.1_Silent_p.P1094P|NCOR2_uc010tbc.1_Silent_p.P1084P|NCOR2_uc001ugj.1_Silent_p.P1102P	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1102					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCGGCAGGACGGGCCGGGCAG	0.667			NA											12	19					0	0	0.080935	0	0
C14orf49	161176	broad.mit.edu	37	14	95932465	95932465	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr14:95932465G>A	uc001yei.3	-	3	445	c.430C>T	c.(430-432)CTG>TTG	p.L144L	C14orf49_uc010avi.2_Silent_p.L144L|C14orf49_uc001yej.1_Silent_p.L144L	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	144	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TTCAGGCCCAGCTGGAGCTCG	0.637			NA											32	41					0	0	0.045705	0	0
PHKB	5257	broad.mit.edu	37	16	47549445	47549445	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr16:47549445C>T	uc002eev.3	+	6	579	c.527C>T	c.(526-528)TCA>TTA	p.S176L	PHKB_uc010vgi.1_Missense_Mutation_p.S169L|PHKB_uc002eeu.3_Missense_Mutation_p.S169L	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	176					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				AATGCAGTGTCACTTTATCTC	0.313			NA											9	26					0	0	0.058154	0	0
MGAT5B	146664	broad.mit.edu	37	17	74921106	74921106	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr17:74921106G>A	uc002jti.2	+	8	1220	c.1117G>A	c.(1117-1119)GAC>AAC	p.D373N	MGAT5B_uc002jth.2_Missense_Mutation_p.D362N	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	362	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CCTGCCCTTCGACCTCATCTA	0.617			NA											15	62					0	0	0.028581	0	0
SLC25A10	1468	broad.mit.edu	37	17	79687107	79687107	+	Nonstop_Mutation	SNP	A	A	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr17:79687107A>C	uc002kbi.2	+	11	950	c.864A>C	c.(862-864)TGA>TGC	p.*288C	SLC25A10_uc010wut.1_Nonstop_Mutation_p.*443C|SLC25A10_uc010dif.2_Nonstop_Mutation_p.*297C|SLC25A10_uc010wuu.1_Nonstop_Mutation_p.*242C	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	288					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	TGCCATCCTGACCAGCCGTGG	0.607			NA											7	27					0	0	0.105934	0	0
SMAD4	4089	broad.mit.edu	37	18	48604655	48604655	+	Missense_Mutation	SNP	G	G	A	rs121912578		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr18:48604655G>A	uc010xdp.1	+	12	2015	c.1477G>A	c.(1477-1479)GAT>AAT	p.D493N	SMAD4_uc002lfb.3_Missense_Mutation_p.D338N	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	493	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)|p.D493A(1)|p.D493H(1)|p.D493N(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		AATTGGTGTTGATGACCTTCG	0.463			NA							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				11	19					0	0	0.105934	0	0
CIRBP	1153	broad.mit.edu	37	19	1270962	1270962	+	Silent	SNP	T	T	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr19:1270962T>G	uc002lrr.3	+	2	179	c.30T>G	c.(28-30)GTT>GTG	p.V10V	C19orf23_uc010xgk.1_5'Flank|CIRBP_uc010dsg.1_5'UTR|CIRBP_uc002lrt.2_Silent_p.V10V|CIRBP_uc010xgl.1_Silent_p.V10V|CIRBP_uc002lrv.3_Silent_p.V10V|CIRBP_uc002lru.2_RNA	NM_001280	NP_001271	Q14011	CIRBP_HUMAN	cold inducible RNA binding protein	10	RRM.				mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		aactttttgttggagggctga	0.378			NA											13	140					0	0	0.105934	0	0
RYR1	6261	broad.mit.edu	37	19	38951104	38951104	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr19:38951104G>A	uc002oit.2	+	20	2580	c.2450G>A	c.(2449-2451)CGA>CAA	p.R817Q	RYR1_uc002oiu.2_Missense_Mutation_p.R817Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	817	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTGCTCCCTCGAGAGCGACTC	0.632			NA											22	69					0	0	0.099896	0	0
FPR1	2357	broad.mit.edu	37	19	52249869	52249869	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr19:52249869C>T	uc002pxq.2	-	2	474	c.379G>A	c.(379-381)GTC>ATC	p.V127I		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	127	Cytoplasmic (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GGATGCAGGACGCAAACACAG	0.557			NA											15	35					0	0	0.049695	0	0
PXDN	7837	broad.mit.edu	37	2	1653369	1653369	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:1653369C>T	uc002qxa.2	-	17	2247	c.2183G>A	c.(2182-2184)CGC>CAC	p.R728H		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	728					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTTGTTCACGCGCCGGTGGGC	0.602			NA											4	61					0	0	0.009096	0	0
GKN2	200504	broad.mit.edu	37	2	69173459	69173459	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:69173459T>G	uc002sfa.2	-	5	558	c.449A>C	c.(448-450)AAG>ACG	p.K150T	GKN2_uc002sfb.3_Missense_Mutation_p.K150T	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	trefoil factor interactions(z) 1 precursor	150	BRICHOS.					extracellular region					0						CACTTCCCCCTTATACAAAGG	0.318			NA											27	63					0	0	0.108266	0	0
MARCO	8685	broad.mit.edu	37	2	119752091	119752091	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:119752091G>A	uc002tln.1	+	17	1690	c.1558G>A	c.(1558-1560)GTC>ATC	p.V520I	MARCO_uc010yyf.1_Missense_Mutation_p.V442I	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	520	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGAGTGCAGCGTCTGACCCGG	0.602	GBM(8;18 374 7467 11269 32796)		NA											13	44					0	0	0.038395	0	0
STAT1	6772	broad.mit.edu	37	2	191873763	191873763	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:191873763G>A	uc002usj.2	-	4	587	c.199C>T	c.(199-201)CAA>TAA	p.Q67*	STAT1_uc010fse.1_Nonsense_Mutation_p.Q67*|STAT1_uc002usk.2_Nonsense_Mutation_p.Q67*|STAT1_uc002usl.2_Nonsense_Mutation_p.Q69*|STAT1_uc010fsf.1_5'UTR	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	67					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	CGACTATATTGATCATCCAGC	0.388			NA											8	20					0	0	0.047766	0	0
COL6A3	1293	broad.mit.edu	37	2	238280738	238280738	+	Missense_Mutation	SNP	G	G	A	rs140330124		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:238280738G>A	uc002vwl.2	-	9	4207	c.3922C>T	c.(3922-3924)CGG>TGG	p.R1308W	COL6A3_uc002vwo.2_Missense_Mutation_p.R1102W|COL6A3_uc010znj.1_Missense_Mutation_p.R701W|COL6A3_uc002vwq.2_Missense_Mutation_p.R1102W|COL6A3_uc002vwr.2_Missense_Mutation_p.R901W	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1308	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTGATCTGCCGCCCTCCCTTG	0.617			NA											4	42					0	0	0.014758	0	0
PROKR2	128674	broad.mit.edu	37	20	5283319	5283319	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr20:5283319G>A	uc010zqw.1	-	2	522	c.522C>T	c.(520-522)ATC>ATT	p.I174I	PROKR2_uc010zqx.1_Silent_p.I174I|PROKR2_uc010zqy.1_Silent_p.I174I	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	174	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						AGACCAAGGCGATCAGGAAGG	0.488			NA								HNSCC(71;0.22)			5	76					0	0	0.014758	0	0
TTLL9	164395	broad.mit.edu	37	20	30522516	30522516	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr20:30522516C>T	uc010gdx.1	+	12	1082	c.829C>T	c.(829-831)CGC>TGC	p.R277C	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_Intron|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Missense_Mutation_p.R179C|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	277	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GACGCTGCAGCGCTTCCGGCA	0.607			NA											4	15					0	0	0.021553	0	0
LAMA5	3911	broad.mit.edu	37	20	60889674	60889674	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr20:60889674G>A	uc002ycq.2	-	61	8371	c.8304C>T	c.(8302-8304)GGC>GGT	p.G2768G		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2768	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGCTCTGGGCCCTGCAGGT	0.647			NA											10	47					0	0	0.069234	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56807778	56807778	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr3:56807778C>T	uc003dig.2	-	2	332	c.163G>A	c.(163-165)GTG>ATG	p.V55M	ARHGEF3_uc011bew.1_Missense_Mutation_p.V55M|ARHGEF3_uc003dih.2_Missense_Mutation_p.V87M|ARHGEF3_uc011bev.1_Missense_Mutation_p.V26M|ARHGEF3_uc003dif.2_Missense_Mutation_p.V61M|ARHGEF3_uc010hmy.1_Translation_Start_Site|ARHGEF3_uc003dii.2_Missense_Mutation_p.V55M	NM_019555	NP_062455	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor 3 isoform	55					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		GTGGCCTTCACGGGCGGGATG	0.478			NA											3	12					0	0	0.014758	0	0
EGF	1950	broad.mit.edu	37	4	110914495	110914495	+	Missense_Mutation	SNP	C	C	T	rs144527372		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr4:110914495C>T	uc003hzy.3	+	19	3279	c.2827C>T	c.(2827-2829)CGC>TGC	p.R943C	EGF_uc011cfu.1_Missense_Mutation_p.R901C|EGF_uc011cfv.1_Intron|EGF_uc010imk.2_Missense_Mutation_p.R91C	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	943	EGF-like 8; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTGTGCTGGACGCCTGTCTGA	0.527			NA											17	64					0	0	0.0333	0	0
SLC4A9	83697	broad.mit.edu	37	5	139751848	139751848	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr5:139751848C>T	uc003lfm.2	+	20	2799	c.2764C>T	c.(2764-2766)CGA>TGA	p.R922*	SLC4A9_uc003lfj.2_Nonsense_Mutation_p.R898*|SLC4A9_uc011czg.1_Nonsense_Mutation_p.R835*|SLC4A9_uc003lfl.2_Nonsense_Mutation_p.R898*|SLC4A9_uc003lfk.2_Nonsense_Mutation_p.R884*	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	922	Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGGGGGTCCGAAAGGCCCT	0.502			NA											6	9					0	0	0.021553	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503027	140503027	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr5:140503027G>A	uc003lip.1	+	1	1447	c.1447G>A	c.(1447-1449)GCC>ACC	p.A483T		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	483	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCACCAACGCCCAGGTCAC	0.657			NA											16	61					0	0	0.049695	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723793	140723793	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr5:140723793C>T	uc003ljm.1	+	1	193	c.193C>T	c.(193-195)CGC>TGC	p.R65C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.R65C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTCCGCATCGTCTC	0.617			NA									OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	113					0	0	0.038147	0	0
ODZ2	57451	broad.mit.edu	37	5	167671581	167671581	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr5:167671581G>A	uc010jjd.2	+	26	5650	c.5650G>A	c.(5650-5652)GTG>ATG	p.V1884M	ODZ2_uc003lzr.3_Missense_Mutation_p.V1654M|ODZ2_uc003lzt.3_Missense_Mutation_p.V1257M|ODZ2_uc010jje.2_Missense_Mutation_p.V1148M	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		AGCTGTCAACGTGTCATACTT	0.597			NA											3	51					0	0	0.004672	0	0
FOXP2	93986	broad.mit.edu	37	7	114282647	114282647	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr7:114282647C>A	uc003vhb.2	+	7	1332	c.958C>A	c.(958-960)CAG>AAG	p.Q320K	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.Q345K|FOXP2_uc003vha.2_Missense_Mutation_p.Q228K|FOXP2_uc011kmu.1_Missense_Mutation_p.Q337K|FOXP2_uc011kmv.1_Missense_Mutation_p.Q319K|FOXP2_uc010ljz.1_Missense_Mutation_p.Q228K|FOXP2_uc003vgx.2_Missense_Mutation_p.Q320K|FOXP2_uc003vhd.2_Missense_Mutation_p.Q320K|FOXP2_uc003vhc.2_Missense_Mutation_p.Q345K	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	320					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						AGTGAATGGACAGTCTTCAGT	0.388			NA											8	74					0.00448238	0.00499958	0.047766	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121651781	121651781	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr7:121651781G>A	uc003vjy.2	+	12	3076	c.2681G>A	c.(2680-2682)AGT>AAT	p.S894N	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	894	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GAATTTGGTAGTGAATCTGGT	0.478			NA											16	30					0	0	0.028581	0	0
SPAM1	6677	broad.mit.edu	37	7	123594255	123594255	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr7:123594255C>T	uc003vld.2	+	4	1033	c.631C>T	c.(631-633)CGG>TGG	p.R211W	SPAM1_uc003vle.2_Missense_Mutation_p.R211W|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.R211W|SPAM1_uc010lku.2_Missense_Mutation_p.R211W	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	211				R->G: Reduces activity by over 90%.	binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AAAATTACTTCGGCCAAATCA	0.378			NA											8	69					0	0	0.038147	0	0
LOC442421	442421	broad.mit.edu	37	9	66499770	66499770	+	Missense_Mutation	SNP	G	G	T	rs75046133		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr9:66499770G>T	uc004aee.1	+	1	580	c.580G>T	c.(580-582)GCC>TCC	p.A194S	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						CAACCTGGTGGCCATCGTGGT	0.582			NA											7	69					0.000673444	0.000765878	0.069234	1	0
CBWD6	644019	broad.mit.edu	37	9	69247529	69247529	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr9:69247529G>A	uc004afj.3	-	5	589	c.483C>T	c.(481-483)TAC>TAT	p.Y161Y	CBWD6_uc004afk.3_Intron|CBWD6_uc011lrf.1_Intron	NM_001085457	NP_001078926	Q4V339	CBWD6_HUMAN	COBW domain containing 6	161							ATP binding				0						TACCATCAAGGTAAATATCAC	0.214			NA											3	18					0	0	0.004672	0	0
GARNL3	84253	broad.mit.edu	37	9	130027251	130027251	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr9:130027251G>A	uc011mae.1	+	1	496	c.95G>A	c.(94-96)GGC>GAC	p.G32D	GARNL3_uc011mad.1_Missense_Mutation_p.G10D	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	32					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGACCTAGGCTGTAGACGT	0.408			NA											20	122					0	0	0.076483	0	0
BMP15	9210	broad.mit.edu	37	X	50659038	50659038	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chrX:50659038C>T	uc011mnw.1	+	2	610	c.610C>T	c.(610-612)CGA>TGA	p.R204*		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	204					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					CAGGATCCTACGACTCCGTTT	0.438			NA											16	25					0	0	0.0333	0	0
KLHL21	9903	broad.mit.edu	37	1	6655560	6655561	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:6655560_6655561insA	uc001aoa.2	-	3	1536_1537	c.1484_1485insT	c.(1483-1485)ATCfs	p.I495fs	KLHL21_uc001anz.1_Frame_Shift_Ins_p.I495fs|KLHL21_uc009vme.2_Frame_Shift_Ins_p.I128fs	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	495	Kelch 5.				anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		TCATGGACGGGATCTTGTCCCA	0.554			NA											9	23	---	---	---	---	NA	NA	NA	NA	NA
RNF43	54894	broad.mit.edu	37	17	56440903	56440904	+	Frame_Shift_Ins	INS	-	-	AT	rs151209912		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr17:56440903_56440904insAT	uc002iwf.2	-	3	2389_2390	c.433_434insAT	c.(433-435)CGAfs	p.R145fs	RNF43_uc010wnv.1_Frame_Shift_Ins_p.R104fs|RNF43_uc002iwh.3_Frame_Shift_Ins_p.R145fs|RNF43_uc002iwg.3_Frame_Shift_Ins_p.R145fs|RNF43_uc010dcw.2_Frame_Shift_Ins_p.R18fs	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	145	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGCAGCAGCTCGATCCTCAGTG	0.594			NA											16	153	---	---	---	---	NA	NA	NA	NA	NA
DNAJC13	23317	broad.mit.edu	37	3	132182659	132182662	+	Splice_Site	DEL	TAGG	TAGG	-			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	TAGG	TAGG	-	-	TAGG	TAGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr3:132182659_132182662delTAGG	uc003eor.2	+	17	1957	c.1892_splice	c.e17+1	p.R631_splice	DNAJC13_uc010htq.1_Splice_Site_p.R631_splice	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13								heat shock protein binding			ovary(1)|breast(1)	2						TGCTTACAAATAGGTAGGTGATTT	0.353			NA											10	77	---	---	---	---	NA	NA	NA	NA	NA
TMEM22	80723	broad.mit.edu	37	3	136573486	136573486	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr3:136573486delA	uc003erf.3	+	2	398	c.184delA	c.(184-186)AAAfs	p.K62fs	TMEM22_uc003erg.3_Frame_Shift_Del_p.K62fs|TMEM22_uc010hub.2_Frame_Shift_Del_p.K62fs	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	62						Golgi apparatus|integral to membrane				ovary(1)	1						GAGTGAAATGAAAAAAAAAGG	0.413			NA											8	141	---	---	---	---	NA	NA	NA	NA	NA
ZDHHC14	79683	broad.mit.edu	37	6	157803062	157803064	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08	CGG	CGG	-	-	CGG	CGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr6:157803062_157803064delCGG	uc003qqt.2	+	1	506_508	c.9_11delCGG	c.(7-12)CCCGGC>CCC	p.G7del	ZDHHC14_uc003qqs.2_In_Frame_Del_p.G7del	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	7						integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GGATGCCTCCCGGCGGCGGCGGG	0.502			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
