Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRDM16	63976	broad.mit.edu	37	1	3319367	3319367	+	Missense_Mutation	SNP	T	T	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr1:3319367T>C	uc001akf.2	+	6	769	c.689T>C	c.(688-690)TTC>TCC	p.F230S	PRDM16_uc001akc.2_Missense_Mutation_p.F230S|PRDM16_uc001akd.2_Missense_Mutation_p.F230S|PRDM16_uc001ake.2_Missense_Mutation_p.F230S|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	230	C2H2-type 1; atypical.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GAGCCCACGTTCCGCTGTGAC	0.627			NA	T	EVI1	MDS|AML								21	73					0	0	0.016522	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887399	12887399	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr1:12887399C>T	uc001auk.2	-	3	654	c.458G>A	c.(457-459)CGC>CAC	p.R153H		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	153											0						TCTGATATTGCGGAAGGGCAT	0.468			NA											142	438					0	0	0.01441	0	0
NT5C1A	84618	broad.mit.edu	37	1	40126786	40126786	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr1:40126786G>A	uc001cdq.1	-	5	706	c.706C>T	c.(706-708)CAT>TAT	p.H236Y		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	236					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCCTTCTCATGCTCGAAGAAT	0.632			NA											6	220					0	0	0.001984	0	0
C1orf125	126859	broad.mit.edu	37	1	179497498	179497498	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr1:179497498C>G	uc001gmo.2	+	23	2774	c.2647C>G	c.(2647-2649)CGA>GGA	p.R883G	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.R809G|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	883	Glu-rich.										0						AAAACTCATTCGATTCATTGG	0.428			NA											3	111					0	0	0.004672	0	0
JMJD4	65094	broad.mit.edu	37	1	227921232	227921232	+	Silent	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr1:227921232G>C	uc001hrb.2	-	4	843	c.843C>G	c.(841-843)CTC>CTG	p.L281L	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|LOC100130093_uc001hqx.3_RNA|LOC100130093_uc001hqy.3_RNA|JMJD4_uc001hrc.2_Silent_p.L281L	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	281	JmjC.										0		Prostate(94;0.0885)				GTGTGTCGCAGAGTGCTGGGG	0.657			NA											6	59					0	0	0.004482	0	0
ACBD5	91452	broad.mit.edu	37	10	27507108	27507108	+	Silent	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr10:27507108C>T	uc010qdp.1	-	7	821	c.630G>A	c.(628-630)AAG>AAA	p.K210K	ACBD5_uc010qdm.1_Silent_p.K208K|ACBD5_uc010qdn.1_Silent_p.K101K|ACBD5_uc010qdo.1_Intron|ACBD5_uc001ito.2_Silent_p.K175K|ACBD5_uc001itp.2_Silent_p.K101K|ACBD5_uc001itq.2_Silent_p.K101K|ACBD5_uc001itr.1_5'UTR	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	219	Potential.				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						TCATCATTTTCTTATCTTTTA	0.353			NA											5	190					0	0	0.001168	0	0
IPMK	253430	broad.mit.edu	37	10	59986896	59986896	+	Missense_Mutation	SNP	T	T	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr10:59986896T>G	uc001jkb.2	-	3	604	c.281A>C	c.(280-282)TAT>TCT	p.Y94S		NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	94						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						GTCAGCAGCATAAACCTGAAA	0.348			NA											10	89					0	0	0.007413	0	0
SAMD8	142891	broad.mit.edu	37	10	76910777	76910777	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr10:76910777G>C	uc001jwx.1	+	2	594	c.491G>C	c.(490-492)GGA>GCA	p.G164A	SAMD8_uc001jwy.1_Missense_Mutation_p.G164A	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	164	Helical; (Potential).				sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					ATAGTATTTGGATTTACATCT	0.358			NA											5	94					0	0	0.014758	0	0
MKI67	4288	broad.mit.edu	37	10	129903821	129903821	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr10:129903821C>T	uc001lke.2	-	13	6478	c.6283G>A	c.(6283-6285)GAT>AAT	p.D2095N	MKI67_uc001lkf.2_Missense_Mutation_p.D1735N|MKI67_uc009yav.1_Missense_Mutation_p.D1670N|MKI67_uc009yaw.1_Missense_Mutation_p.D1245N	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2095	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTTTTGTCATCAGTTGTTGAT	0.498			NA											8	509					0	0	0.004482	0	0
CKAP5	9793	broad.mit.edu	37	11	46829658	46829658	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr11:46829658C>G	uc001ndi.1	-	8	1011	c.901G>C	c.(901-903)GAG>CAG	p.E301Q	CKAP5_uc009ylg.1_Missense_Mutation_p.E187Q|CKAP5_uc001ndj.1_Missense_Mutation_p.E301Q	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	301					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TCTACAGACTCCAGGGCCTCT	0.368	Ovarian(4;85 273 2202 4844 13323)		NA											6	471					0	0	0.001984	0	0
CKAP5	9793	broad.mit.edu	37	11	46829676	46829676	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr11:46829676C>G	uc001ndi.1	-	8	993	c.883G>C	c.(883-885)GAG>CAG	p.E295Q	CKAP5_uc009ylg.1_Missense_Mutation_p.E181Q|CKAP5_uc001ndj.1_Missense_Mutation_p.E295Q	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	295					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TCTTTTCTCTCTTGCCATTTT	0.363	Ovarian(4;85 273 2202 4844 13323)		NA											5	440					0	0	0.014758	0	0
ATG16L2	89849	broad.mit.edu	37	11	72535874	72535874	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr11:72535874C>T	uc001otd.2	+	9	1023	c.983C>T	c.(982-984)GCT>GTT	p.A328V	ATG16L2_uc010rrf.1_3'UTR|ATG16L2_uc001ote.2_Missense_Mutation_p.A222V|ATG16L2_uc009ytj.1_Intron|ATG16L2_uc001otf.2_Missense_Mutation_p.A83V|ATG16L2_uc001otg.2_Missense_Mutation_p.A62V|ATG16L2_uc009ytk.2_Missense_Mutation_p.A83V	NM_033388	NP_203746	Q8NAA4	A16L2_HUMAN	ATG16 autophagy related 16-like 2	328					autophagy|protein transport	cytoplasm	protein binding				0			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			CCTACCCGGGCTCAGGATGTG	0.612			NA											12	47					0	0	0.016723	0	0
INTS4	92105	broad.mit.edu	37	11	77618831	77618831	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr11:77618831G>A	uc001oys.2	-	16	1976	c.1948C>T	c.(1948-1950)CAA>TAA	p.Q650*	C11orf67_uc001oyp.2_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	650					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AATTCAGATTGAAGTTCTCCA	0.408			NA											4	89					0	0	0.00308	0	0
TRPC6	7225	broad.mit.edu	37	11	101353717	101353717	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr11:101353717G>C	uc001pgk.3	-	5	1898	c.1473C>G	c.(1471-1473)TTC>TTG	p.F491L	TRPC6_uc009ywy.2_Missense_Mutation_p.F375L|TRPC6_uc009ywz.1_Missense_Mutation_p.F436L	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	491	Helical; (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CCATCCATGAGAAGCAGGATG	0.403	Colon(166;1315 1927 11094 12848 34731)		NA											4	211					0	0	0.009096	0	0
RAD52	5893	broad.mit.edu	37	12	1022604	1022604	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr12:1022604G>C	uc001qis.1	-	12	1324	c.1210C>G	c.(1210-1212)CAT>GAT	p.H404D	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.H327D|RAD52_uc001qiu.1_Missense_Mutation_p.H404D	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	404					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			CTCTTCCTATGAGATTCCCAG	0.368			NA						Homologous_recombination					6	262					0	0	0.001168	0	0
LOC642846	642846	broad.mit.edu	37	12	9447488	9447488	+	Missense_Mutation	SNP	C	C	T	rs75114985		TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr12:9447488C>T	uc010sgq.1	+	5	569	c.478C>T	c.(478-480)CGG>TGG	p.R160W	LOC642846_uc010sgp.1_RNA|LOC642846_uc009zgn.1_Missense_Mutation_p.R10W|LOC642846_uc001qvo.2_Missense_Mutation_p.R10W					SubName: Full=cDNA FLJ60032, highly similar to Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-);												0						GGAGGCCGAGCGGCTGGAGCA	0.622			NA											3	7					0	0	0.014758	0	0
CMAS	55907	broad.mit.edu	37	12	22208509	22208509	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr12:22208509G>A	uc001rfm.2	+	3	603	c.524G>A	c.(523-525)CGC>CAC	p.R175H	CMAS_uc001rfn.2_RNA	NM_018686	NP_061156	Q8NFW8	NEUA_HUMAN	cytidine monophospho-N-acetylneuraminic acid	175					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3						GTTGTGAGACGCCATCAGTTT	0.323			NA											5	171					0	0	0.001984	0	0
PKP2	5318	broad.mit.edu	37	12	32955458	32955458	+	Silent	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr12:32955458C>T	uc001rlj.3	-	11	2293	c.2178G>A	c.(2176-2178)CAG>CAA	p.Q726Q	PKP2_uc001rlk.3_Silent_p.Q682Q|PKP2_uc010skj.1_Silent_p.Q679Q	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	726	ARM 6.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CACTTTCCTTCTGGACAACTG	0.453			NA											8	251					0	0	0.004482	0	0
PLEKHG7	440107	broad.mit.edu	37	12	93135270	93135270	+	Missense_Mutation	SNP	A	A	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr12:93135270A>G	uc001tcj.2	+	4	333	c.103A>G	c.(103-105)AGC>GGC	p.S35G		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	35	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						TCCCTAGACAAGCCTTGGTTT	0.403			NA											4	228					0	0	0.009096	0	0
BRCA2	675	broad.mit.edu	37	13	32972777	32972777	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr13:32972777C>G	uc001uub.1	+	27	10354	c.10127C>G	c.(10126-10128)TCA>TGA	p.S3376*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3376					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CCCACCAGTTCAGAAGATTAT	0.413	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			5	91					0	0	0.014758	0	0
PSME2	5721	broad.mit.edu	37	14	24614335	24614335	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr14:24614335C>A	uc001wmj.2	-	6	357	c.292G>T	c.(292-294)GAG>TAG	p.E98*	PSME2_uc001wmk.2_Nonsense_Mutation_p.E21*|RNF31_uc001wml.1_5'Flank|RNF31_uc001wmm.1_5'Flank|RNF31_uc001wmn.1_5'Flank|RNF31_uc010alg.1_5'Flank	NM_002818	NP_002809	Q9UL46	PSME2_HUMAN	proteasome activator subunit 2	98					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex					0				GBM - Glioblastoma multiforme(265;0.00839)		AGGACTTTCTCATTCCCAGGG	0.507			NA											7	335					0.00198382	0.00208231	0.001984	1	0
REC8	9985	broad.mit.edu	37	14	24648000	24648000	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr14:24648000G>A	uc001wmr.2	+	16	1508	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	REC8_uc001wms.2_Missense_Mutation_p.E361K	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	361	Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		GCTACCCCCTGAACTACTGGG	0.582	NSCLC(139;1764 2537 12868 49041)		NA											8	559					0	0	0.004482	0	0
TTLL5	23093	broad.mit.edu	37	14	76149969	76149969	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr14:76149969C>T	uc001xrx.2	+	5	546	c.341C>T	c.(340-342)TCT>TTT	p.S114F	TTLL5_uc001xrw.1_Missense_Mutation_p.S114F|TTLL5_uc010ask.1_Missense_Mutation_p.S114F|TTLL5_uc001xrv.2_Missense_Mutation_p.S114F	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	114	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		CGCACCCTCTCTGAAGCACAA	0.468			NA											4	188					0	0	0.009096	0	0
KCNK13	56659	broad.mit.edu	37	14	90650993	90650993	+	Silent	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr14:90650993G>C	uc001xye.1	+	2	1315	c.873G>C	c.(871-873)CTG>CTC	p.L291L		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	291	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				ACTGGATCCTGAGGAAAATGG	0.537			NA											3	191					0	0	0.004672	0	0
LGMN	5641	broad.mit.edu	37	14	93183754	93183754	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr14:93183754G>C	uc001yav.2	-	5	615	c.289C>G	c.(289-291)CAG>GAG	p.Q97E	LGMN_uc001yat.2_Missense_Mutation_p.Q97E|LGMN_uc001yau.2_Missense_Mutation_p.Q97E|LGMN_uc001yaw.2_Missense_Mutation_p.Q97E|LGMN_uc010aul.2_Missense_Mutation_p.I6M|LGMN_uc001yax.2_Missense_Mutation_p.Q97E|LGMN_uc001yay.2_Missense_Mutation_p.Q97E	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	97					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		GGGACTCCCTGATAGACATCT	0.458			NA											4	231					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	15	20644850	20644850	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr15:20644850G>A	uc001ytg.2	-	21	3117	c.2408C>T	c.(2407-2409)GCG>GTG	p.A803V	uc010tyx.1_RNA|uc001yth.3_Missense_Mutation_p.A803V|uc010tyy.1_Missense_Mutation_p.A803V					RecName: Full=Putative HERC2-like protein 3;												NA						CATGTCCCTCGCCCTTTCGGT	0.463			NA											3	43					0	0	0.004672	0	0
LEO1	123169	broad.mit.edu	37	15	52258273	52258273	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr15:52258273C>T	uc002abo.2	-	2	503	c.487G>A	c.(487-489)GAT>AAT	p.D163N	LEO1_uc010bfd.2_Missense_Mutation_p.D163N	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	163	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		TCCTCATCATCAGAATTTTGT	0.413	Esophageal Squamous(40;229 896 18505 32465 43844)|Ovarian(53;886 1123 14462 18432 23189)		NA											14	431					0	0	0.020292	0	0
NARG2	79664	broad.mit.edu	37	15	60720680	60720680	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr15:60720680C>G	uc002agp.2	-	15	3003	c.2768G>C	c.(2767-2769)AGA>ACA	p.R923T	NARG2_uc002ago.2_Missense_Mutation_p.R786T	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	923						nucleus				ovary(1)|lung(1)	2						ACAAGGTATTCTTCCATGATG	0.398			NA											4	177					0	0	0.009096	0	0
IFT140	9742	broad.mit.edu	37	16	1616277	1616277	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr16:1616277C>G	uc002cmb.2	-	16	2148	c.1786G>C	c.(1786-1788)GAT>CAT	p.D596H	IFT140_uc002clz.2_Missense_Mutation_p.D247H	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	596										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				ATTTTGGAATCAGGGCTGTTG	0.507			NA											4	183					0	0	0.009096	0	0
NSMCE1	197370	broad.mit.edu	37	16	27245538	27245538	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr16:27245538C>G	uc002doi.1	-	4	405	c.307G>C	c.(307-309)GAG>CAG	p.E103Q	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	103					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						AGTTCATTCTCTGCAAAATCC	0.433			NA											4	191					0	0	0.009096	0	0
KIF22	3835	broad.mit.edu	37	16	29816619	29816619	+	Silent	SNP	T	T	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr16:29816619T>C	uc002dts.3	+	14	2010	c.1986T>C	c.(1984-1986)TGT>TGC	p.C662C	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Silent_p.C594C|KIF22_uc010vdw.1_Silent_p.C594C|KIF22_uc010bzf.2_Silent_p.C608C|KIF22_uc002dtt.1_3'UTR|KIF22_uc002frc.1_RNA|MAZ_uc002dtv.1_5'Flank|MAZ_uc010vdx.1_5'Flank|MAZ_uc002dtw.2_5'Flank|MAZ_uc002dtx.2_5'Flank|MAZ_uc002dty.2_5'Flank|MAZ_uc010bzg.2_5'Flank|MAZ_uc002dtz.1_5'Flank|MAZ_uc002dua.2_5'Flank|MAZ_uc010vdy.1_5'Flank	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	662					blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						GCCAGCGCTGTGGCGCCTCCT	0.592			NA											59	250					0	0	0.01441	0	0
HEATR3	55027	broad.mit.edu	37	16	50112902	50112902	+	Silent	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr16:50112902G>A	uc002efw.2	+	7	1176	c.1014G>A	c.(1012-1014)AGG>AGA	p.R338R	HEATR3_uc002efx.2_Silent_p.R252R	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	338							binding			ovary(1)|skin(1)	2						GAGTCAGAAGGAAAACTTTCG	0.368			NA											4	169					0	0	0.009096	0	0
NLRC5	84166	broad.mit.edu	37	16	57054780	57054780	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr16:57054780G>C	uc002ekk.1	+	3	381	c.156G>C	c.(154-156)CAG>CAC	p.Q52H	NLRC5_uc010ccq.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	52					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				ACCCTGAACAGAGAGTCATCC	0.547			NA											4	99					0	0	0.014758	0	0
GLG1	2734	broad.mit.edu	37	16	74496473	74496473	+	Missense_Mutation	SNP	G	G	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr16:74496473G>T	uc002fcy.3	-	21	2897	c.2847C>A	c.(2845-2847)TTC>TTA	p.F949L	GLG1_uc002fcx.2_Missense_Mutation_p.F949L|GLG1_uc002fcw.3_Missense_Mutation_p.F938L|GLG1_uc002fcz.3_Missense_Mutation_p.F366L	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	949	Cys-rich GLG1 14.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						TACCGTGACAGAATTTAGGAA	0.433			NA											29	91					4.59853e-10	4.93176e-10	0.005443	1	0
PLD2	5338	broad.mit.edu	37	17	4719995	4719995	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr17:4719995C>G	uc002fzc.2	+	15	1637	c.1536C>G	c.(1534-1536)AGC>AGG	p.S512R	PLD2_uc010vsj.1_Missense_Mutation_p.S369R|PLD2_uc002fzd.2_Missense_Mutation_p.S512R	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	512	Catalytic.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	AGGACTACAGCAATCTTATCA	0.607			NA											45	141					0	0	0.013114	0	0
MYO18A	399687	broad.mit.edu	37	17	27413574	27413574	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr17:27413574C>G	uc002hdt.1	-	39	5892	c.5734G>C	c.(5734-5736)GAG>CAG	p.E1912Q	MYO18A_uc010wbc.1_Missense_Mutation_p.E1445Q|MYO18A_uc002hds.2_Missense_Mutation_p.E1454Q|MYO18A_uc010csa.1_Missense_Mutation_p.E1875Q|MYO18A_uc002hdu.1_Missense_Mutation_p.E1912Q	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1912	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TTAGCAGCCTCCAGGCTTTCT	0.557	Esophageal Squamous(182;472 2015 7001 15270 22562)		NA											3	49					0	0	0.009096	0	0
WIPF2	147179	broad.mit.edu	37	17	38430162	38430162	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr17:38430162C>G	uc002hug.1	+	6	1331	c.1091C>G	c.(1090-1092)TCA>TGA	p.S364*	WIPF2_uc002huh.1_Nonsense_Mutation_p.S214*|WIPF2_uc010cww.1_Nonsense_Mutation_p.S214*|WIPF2_uc002hui.1_Nonsense_Mutation_p.S364*|WIPF2_uc010cwx.1_Nonsense_Mutation_p.S106*|WIPF2_uc010cwy.1_Nonsense_Mutation_p.S364*	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	364						cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						CCTCCACCCTCAAGGACGCCA	0.622			NA								HNSCC(43;0.11)			4	169					0	0	0.001984	0	0
KRT15	3866	broad.mit.edu	37	17	39675033	39675033	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr17:39675033C>T	uc002hwy.2	-	1	238	c.47G>A	c.(46-48)GGC>GAC	p.G16D	KRT15_uc002hwz.2_5'UTR|KRT15_uc002hxa.2_5'UTR|KRT15_uc002hxb.1_Intron	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	16	Gly-rich.|Head.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TCGGGTTGAGCCACCCCCAAA	0.597			NA											4	217					0	0	0.009096	0	0
ITGA2B	3674	broad.mit.edu	37	17	42453323	42453323	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr17:42453323C>T	uc002igt.1	-	25	2511	c.2479G>A	c.(2479-2481)GGT>AGT	p.G827S	ITGA2B_uc002igu.1_Missense_Mutation_p.G308S	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	827	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	AGGTGAAGACCATTCACAGTC	0.622			NA									OREG0024460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	67					0	0	0.009096	0	0
RNF213	57674	broad.mit.edu	37	17	78321357	78321357	+	Silent	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr17:78321357C>T	uc002jyh.1	+	4	3664	c.3441C>T	c.(3439-3441)TTC>TTT	p.F1147F		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTTCTGGTTTCCCCAAGGACC	0.502			NA											6	209					0	0	0.001984	0	0
ANKRD12	23253	broad.mit.edu	37	18	9275652	9275652	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr18:9275652C>T	uc002knv.2	+	11	6151	c.5894C>T	c.(5893-5895)CCA>CTA	p.P1965L	ANKRD12_uc002knw.2_Missense_Mutation_p.P1942L|ANKRD12_uc002knx.2_Missense_Mutation_p.P1942L	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1965						nucleus				ovary(2)|central_nervous_system(1)	3						TACAATGTACCATTGGACTCT	0.358			NA											42	154					0	0	0.010771	0	0
TWSG1	57045	broad.mit.edu	37	18	9396396	9396396	+	Silent	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr18:9396396G>A	uc002knz.2	+	4	533	c.342G>A	c.(340-342)TTG>TTA	p.L114L	TWSG1_uc002koa.2_Silent_p.L39L	NM_020648	NP_065699	Q9GZX9	TWSG1_HUMAN	twisted gastrulation precursor	114										ovary(1)|pancreas(1)	2						ATACTCAGTTGAATTGGAACA	0.448			NA											5	234					0	0	0.014758	0	0
MC5R	4161	broad.mit.edu	37	18	13826656	13826656	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr18:13826656C>T	uc010xaf.1	+	1	892	c.892C>T	c.(892-894)CGC>TGC	p.R298C		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	298	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						ATATGCCTTCCGCAGCCAAGA	0.483			NA											55	178					0	0	0.01441	0	0
NETO1	81832	broad.mit.edu	37	18	70416305	70416305	+	Silent	SNP	A	A	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr18:70416305A>G	uc002lkw.2	-	10	1844	c.1560T>C	c.(1558-1560)TCT>TCC	p.S520S	NETO1_uc002lkx.1_Silent_p.S519S|NETO1_uc002lky.1_Silent_p.S520S	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	520	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GTTTGCTTAGAGACCCAATGA	0.343			NA											34	168					0	0	0.007835	0	0
C19orf29	58509	broad.mit.edu	37	19	3612168	3612168	+	Missense_Mutation	SNP	T	T	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:3612168T>A	uc002lyh.2	-	10	2083	c.2030A>T	c.(2029-2031)AAG>ATG	p.K677M	C19orf29_uc010xho.1_Missense_Mutation_p.K136M|C19orf29_uc010dtn.2_Missense_Mutation_p.K525M|C19orf29_uc002lyi.3_Missense_Mutation_p.K677M|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	677						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GATGTTGAACTTGTATCCCTG	0.572			NA											8	265					0	0	0.00308	0	0
ZNF558	148156	broad.mit.edu	37	19	8922322	8922322	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:8922322G>A	uc002mkn.1	-	6	1074	c.844C>T	c.(844-846)CAC>TAC	p.H282Y	ZNF558_uc010xkh.1_Missense_Mutation_p.H211Y|ZNF558_uc010dwg.1_Missense_Mutation_p.H282Y	NM_144693	NP_653294	Q96NG5	ZN558_HUMAN	zinc finger protein 558	282	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1						ATGCTATTGTGCCCAGTGAGA	0.453			NA											65	221					0	0	0.01441	0	0
EID2	163126	broad.mit.edu	37	19	40030139	40030139	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:40030139G>A	uc002oma.2	-	1	700	c.581C>T	c.(580-582)GCC>GTC	p.A194V		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	194					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CTGATATTCGGCATCAAACGC	0.488			NA											4	232					0	0	0.001168	0	0
RTN2	6253	broad.mit.edu	37	19	45998365	45998365	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:45998365C>G	uc002pcb.2	-	2	295	c.67G>C	c.(67-69)GAT>CAT	p.D23H	RTN2_uc002pcc.2_Missense_Mutation_p.D23H|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	23						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		TCTGTGGAATCAGGAGTTGAG	0.547			NA											6	171					0	0	0.001168	0	0
GRWD1	83743	broad.mit.edu	37	19	48949420	48949420	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:48949420C>T	uc002pjd.2	+	1	391	c.158C>T	c.(157-159)GCC>GTC	p.A53V		NM_031485	NP_113673	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	53						nucleolus				ovary(1)	1		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		GACGAGGAGGCCTATGTGCTC	0.677			NA									OREG0025607	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	13					0	0	0.009096	0	0
ZNF761	388561	broad.mit.edu	37	19	53959208	53959208	+	Missense_Mutation	SNP	A	A	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:53959208A>G	uc010eqp.2	+	7	1905	c.1447A>G	c.(1447-1449)AGA>GGA	p.R483G	ZNF761_uc010ydy.1_Missense_Mutation_p.R429G|ZNF761_uc002qbt.1_Missense_Mutation_p.R429G	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	483	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AAACCTTGAAAGACATAGGAG	0.413			NA											3	147					0	0	0.004672	0	0
NLRP4	147945	broad.mit.edu	37	19	56382256	56382256	+	Missense_Mutation	SNP	C	C	G	rs145998081		TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:56382256C>G	uc002qmd.3	+	7	2840	c.2418C>G	c.(2416-2418)AAC>AAG	p.N806K	NLRP4_uc002qmf.2_Missense_Mutation_p.N731K|NLRP4_uc010etf.2_Missense_Mutation_p.N581K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	806	LRR 5.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TTCTGCGTAACAAGAGCGTGC	0.517			NA											4	123					0	0	0.009096	0	0
PEG3	5178	broad.mit.edu	37	19	57325423	57325423	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr19:57325423C>T	uc002qnu.2	-	7	4738	c.4387G>A	c.(4387-4389)GAA>AAA	p.E1463K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E1434K|PEG3_uc002qnv.2_Missense_Mutation_p.E1463K|PEG3_uc002qnw.2_Missense_Mutation_p.E1339K|PEG3_uc002qnx.2_Missense_Mutation_p.E1337K|PEG3_uc010etr.2_Missense_Mutation_p.E1463K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1463	Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCAGCTCTTTCTTCTGGGTCT	0.547			NA											6	218					0	0	0.001984	0	0
FAM49A	81553	broad.mit.edu	37	2	16740826	16740826	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:16740826C>T	uc010exm.1	-	9	887	c.739G>A	c.(739-741)GAG>AAG	p.E247K	FAM49A_uc002rck.1_Missense_Mutation_p.E247K	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	247						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			ATCAGGGTCTCTTCACTCGTA	0.502			NA											4	187					0	0	0.001168	0	0
PREPL	9581	broad.mit.edu	37	2	44571027	44571027	+	Missense_Mutation	SNP	A	A	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:44571027A>G	uc002ruf.2	-	4	508	c.473T>C	c.(472-474)ATT>ACT	p.I158T	PREPL_uc002rug.2_Missense_Mutation_p.I158T|PREPL_uc002ruh.2_Missense_Mutation_p.I158T|PREPL_uc010fax.2_Missense_Mutation_p.I158T|PREPL_uc002rui.3_Missense_Mutation_p.I69T|PREPL_uc002ruj.1_Missense_Mutation_p.I69T|PREPL_uc002ruk.1_Missense_Mutation_p.I158T	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	158					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GATACAATCAATGAAGGGCTG	0.343			NA											59	151					0	0	0.01441	0	0
CLEC4F	165530	broad.mit.edu	37	2	71039638	71039638	+	Missense_Mutation	SNP	C	C	G	rs142013309	byFrequency	TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:71039638C>G	uc002shf.2	-	5	1557	c.1480G>C	c.(1480-1482)GAG>CAG	p.E494Q	CLEC4F_uc010yqv.1_Missense_Mutation_p.E494Q	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	494	Extracellular (Potential).|C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						CAGAACTGCTCAGCCTCATGC	0.532	Colon(107;10 2157 6841 26035)		NA											3	169					0	0	0.014758	0	0
NCAPH	23397	broad.mit.edu	37	2	97039033	97039033	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:97039033C>G	uc002svz.1	+	18	2254	c.2170C>G	c.(2170-2172)CTA>GTA	p.L724V	NCAPH_uc010yum.1_Missense_Mutation_p.L700V|NCAPH_uc010fhw.1_Missense_Mutation_p.L713V|NCAPH_uc010yun.1_Missense_Mutation_p.L588V|NCAPH_uc002swa.1_Missense_Mutation_p.L319V	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	724					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CCCTCAGAATCTAAAACTGGA	0.433			NA											6	214					0	0	0.00308	0	0
C2orf60	129450	broad.mit.edu	37	2	200800672	200800672	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:200800672C>T	uc002uvi.3	-	7	939	c.673G>A	c.(673-675)GAT>AAT	p.D225N	C2orf60_uc002uvj.3_Missense_Mutation_p.D62N|C2orf60_uc002uvk.3_RNA|C2orf60_uc010fss.2_Missense_Mutation_p.D62N	NM_001039693	NP_001034782	A2RUC4	TYW5_HUMAN	hypothetical protein LOC129450	225	JmjC.				wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0						AATAATACATCACCAGCTTCA	0.333			NA											4	192					0	0	0.009096	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638177	234638177	+	Missense_Mutation	SNP	G	G	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:234638177G>T	uc002vuy.2	+	1	405	c.405G>T	c.(403-405)GAG>GAT	p.E135D	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.E135D	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	135					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TACATAATGAGGCCCTGATCA	0.428			NA											101	326					1.70349e-48	1.88147e-48	0.01441	1	0
COL6A3	1293	broad.mit.edu	37	2	238277314	238277314	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:238277314C>G	uc002vwl.2	-	10	5077	c.4792G>C	c.(4792-4794)GAG>CAG	p.E1598Q	COL6A3_uc002vwo.2_Missense_Mutation_p.E1392Q|COL6A3_uc010znj.1_Missense_Mutation_p.E991Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1598	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TCTCTGAACTCTCGCACTGTG	0.547			NA											5	385					0	0	0.014758	0	0
PAX1	5075	broad.mit.edu	37	20	21689285	21689285	+	Missense_Mutation	SNP	G	G	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr20:21689285G>T	uc002wsj.2	+	3	1060	c.1006G>T	c.(1006-1008)GCA>TCA	p.A336S	PAX1_uc010zsl.1_Missense_Mutation_p.A336S|PAX1_uc010zsm.1_Missense_Mutation_p.A312S	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	336					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CGCCACCCCCGCAGTGAATGG	0.602			NA											60	85					3.66258e-25	3.98575e-25	0.01441	1	0
C20orf186	149954	broad.mit.edu	37	20	31685500	31685500	+	Silent	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr20:31685500G>A	uc010zue.1	+	11	1491	c.1476G>A	c.(1474-1476)CAG>CAA	p.Q492Q		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	492						cytoplasm|extracellular region	lipid binding				0						TGATGCTGCAGAAGGACAAAG	0.582			NA											6	284					0	0	0.001984	0	0
MYH7B	57644	broad.mit.edu	37	20	33575404	33575404	+	Missense_Mutation	SNP	C	C	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr20:33575404C>A	uc002xbi.1	+	15	1410	c.1318C>A	c.(1318-1320)CTC>ATC	p.L440I	MIR499_hsa-mir-499|MI0003183_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	398	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CAGTGGGGACCTCCTCAAAGG	0.637			NA											121	194					3.68091e-61	4.09605e-61	0.01441	1	0
CABLES2	81928	broad.mit.edu	37	20	60967531	60967531	+	Silent	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr20:60967531C>T	uc002ycv.2	-	8	1012	c.1005G>A	c.(1003-1005)GTG>GTA	p.V335V		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	335					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			CTGAGGGCTTCACGTATTCTA	0.557			NA											7	273					0	0	0.00308	0	0
TCFL5	10732	broad.mit.edu	37	20	61488962	61488962	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr20:61488962C>G	uc002ydp.2	-	4	1116	c.1023G>C	c.(1021-1023)AAG>AAC	p.K341N	TCFL5_uc002ydo.2_Missense_Mutation_p.K114N|TCFL5_uc002ydq.2_Missense_Mutation_p.K340N	NM_006602	NP_006593	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 protein	341					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)	1	Breast(26;5.68e-08)					TCCGATTCCTCTTCAGTGCTT	0.438			NA											5	181					0	0	0.001168	0	0
SLC17A9	63910	broad.mit.edu	37	20	61598814	61598814	+	Missense_Mutation	SNP	C	C	G	rs112598584		TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr20:61598814C>G	uc002yea.3	+	13	1457	c.1273C>G	c.(1273-1275)CAG>GAG	p.Q425E	SLC17A9_uc002ydz.3_Missense_Mutation_p.Q419E|SLC17A9_uc011aap.1_3'UTR	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	425					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TGGACAGGCTCAGAGGGTGGA	0.612			NA											4	230					0	0	0.014758	0	0
ITSN1	6453	broad.mit.edu	37	21	35260596	35260596	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr21:35260596G>A	uc002yta.1	+	40	5426	c.5158G>A	c.(5158-5160)GAG>AAG	p.E1720K	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Missense_Mutation_p.E1715K|ITSN1_uc002ytj.2_Missense_Mutation_p.E1659K|ITSN1_uc010gmm.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1720					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						GTTGTTTGATGAGCCGTAGGC	0.547			NA											12	31					0	0	0.010729	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057394	46057394	+	Silent	SNP	C	C	T	rs150164802		TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr21:46057394C>T	uc002zfq.2	+	1	122	c.60C>T	c.(58-60)GTC>GTT	p.V20V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	20						keratin filament					0						GGCGGGTAGTCGACTGCCCAG	0.647			NA											7	126					0	0	0.013726	0	0
POTEH	23784	broad.mit.edu	37	22	16267027	16267027	+	Silent	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr22:16267027G>C	uc010gqp.2	-	9	1474	c.1422C>G	c.(1420-1422)GCC>GCG	p.A474A	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Silent_p.A193A|POTEH_uc002zlj.1_Silent_p.A309A	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	474										skin(1)	1						TGTCAGCAGTGGCACCGTTAG	0.408			NA											13	572					0	0	0.016723	0	0
C22orf29	79680	broad.mit.edu	37	22	19839364	19839364	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr22:19839364C>A	uc002zqg.2	-	2	1020	c.421G>T	c.(421-423)GAG>TAG	p.E141*	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Nonsense_Mutation_p.E141*|C22orf29_uc002zqi.2_Nonsense_Mutation_p.E141*|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	141											0	Colorectal(54;0.0993)					CTGAGGATCTCGCAGACACGG	0.612			NA											8	204					9.70103e-10	1.03292e-09	0.008291	1	0
ZDHHC8	29801	broad.mit.edu	37	22	20128410	20128410	+	Missense_Mutation	SNP	C	C	T	rs137905034		TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr22:20128410C>T	uc002zrq.2	+	7	875	c.769C>T	c.(769-771)CCC>TCC	p.P257S	ZDHHC8_uc002zrr.1_Missense_Mutation_p.P257S|ZDHHC8_uc010gsa.2_Missense_Mutation_p.P63S	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	257	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					GGTGGAGCCACCCCGGCTGCC	0.627			NA											12	58					0	0	0.003163	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37462203	37462203	+	Silent	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr22:37462203G>A	uc003aqs.1	-	18	2467	c.2353C>T	c.(2353-2355)CTG>TTG	p.L785L	TMPRSS6_uc003aqt.1_Silent_p.L798L	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	785	Peptidase S1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						CCACAGCCCAGGCCCCAGCTG	0.632			NA											9	26					0	0	0.020292	0	0
APOBEC3G	60489	broad.mit.edu	37	22	39477517	39477517	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr22:39477517G>C	uc003awx.2	+	4	850	c.508G>C	c.(508-510)GAG>CAG	p.E170Q	APOBEC3G_uc003awy.2_Missense_Mutation_p.E103Q	NM_021822	NP_068594	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	170					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding	p.E170K(1)		central_nervous_system(1)|skin(1)	2	Melanoma(58;0.04)					CAGCCAAAGAGAGCTATTTGA	0.478			NA											7	283					0	0	0.00308	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48716054	48716054	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr3:48716054C>G	uc003cun.2	-	12	2002	c.1908G>C	c.(1906-1908)ATG>ATC	p.M636I	NCKIPSD_uc003cum.2_Missense_Mutation_p.M629I	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	636					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGAGAGCCATCATGTCTGTGT	0.572			NA											4	116					0	0	0.009096	0	0
CEP97	79598	broad.mit.edu	37	3	101476618	101476618	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr3:101476618G>A	uc003dvk.1	+	9	1195	c.1168G>A	c.(1168-1170)GAT>AAT	p.D390N	CEP97_uc010hpm.1_Missense_Mutation_p.D356N|CEP97_uc011bhf.1_Intron|CEP97_uc003dvl.1_Missense_Mutation_p.D86N|CEP97_uc003dvm.1_Missense_Mutation_p.D228N	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	390	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						CATACAGACGGATGAGGACAA	0.418			NA											28	123					0	0	0.008361	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101572387	101572387	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr3:101572387C>G	uc003dvp.2	+	5	1132	c.1017C>G	c.(1015-1017)AGC>AGG	p.S339R	NFKBIZ_uc003dvo.2_Missense_Mutation_p.S239R|NFKBIZ_uc010hpo.2_Missense_Mutation_p.S239R|NFKBIZ_uc003dvq.2_Intron	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	339	Required for transcriptional activity (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						CAAACCAAAGCTTAGTTTCCC	0.458			NA											6	196					0	0	0.001168	0	0
DPPA2	151871	broad.mit.edu	37	3	109027921	109027921	+	Silent	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr3:109027921G>A	uc003dxo.2	-	5	595	c.348C>T	c.(346-348)ATC>ATT	p.I116I		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	116	SAP.					nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						GATAAACTTCGATTTTCTTAG	0.408			NA											11	316					0	0	0.008291	0	0
WDR52	55779	broad.mit.edu	37	3	113120482	113120482	+	Silent	SNP	G	G	A	rs143438550	by1000genomes	TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr3:113120482G>A	uc003eae.1	-	10	1321	c.1275C>T	c.(1273-1275)CTC>CTT	p.L425L		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	425										central_nervous_system(1)	1						TCATAGAGAAGAGATTCACAT	0.363			NA											4	96					0	0	0.009096	0	0
PAQR9	344838	broad.mit.edu	37	3	142681704	142681704	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr3:142681704C>T	uc003evg.2	-	1	475	c.475G>A	c.(475-477)GCG>ACG	p.A159T	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	159	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CTGATGGACGCGTAGTCCAGG	0.612			NA											3	16					0	0	0.001168	0	0
CPA3	1359	broad.mit.edu	37	3	148586705	148586705	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr3:148586705G>C	uc003ewm.2	+	3	200	c.148G>C	c.(148-150)GAC>CAC	p.D50H		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	50					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TCTGCAGCTTGACTTCTGGTA	0.428			NA											5	132					0	0	0.014758	0	0
FRYL	285527	broad.mit.edu	37	4	48636353	48636353	+	Silent	SNP	A	A	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr4:48636353A>C	uc003gyh.1	-	4	680	c.75T>G	c.(73-75)GCT>GCG	p.A25A	FRYL_uc003gyk.2_Silent_p.A25A|FRYL_uc003gyl.1_Silent_p.A76A|FRYL_uc003gym.1_Silent_p.A25A	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CAGCTTGAACAGCAAATTCTG	0.368			NA											46	128					0	0	0.01441	0	0
THAP6	152815	broad.mit.edu	37	4	76452395	76452395	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr4:76452395G>C	uc003him.2	+	5	737	c.640G>C	c.(640-642)GAG>CAG	p.E214Q	THAP6_uc003hin.2_Missense_Mutation_p.E172Q|THAP6_uc011cbm.1_Intron|THAP6_uc010iiu.1_Intron|THAP6_uc003hio.1_Intron|THAP6_uc010iiv.2_Missense_Mutation_p.E214Q	NM_144721	NP_653322	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	214						microtubule cytoskeleton	DNA binding|metal ion binding				0			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CTGTTGTCAGGAGAGCATAGA	0.348			NA											6	201					0	0	0.00308	0	0
CCNI	10983	broad.mit.edu	37	4	77969418	77969418	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr4:77969418C>T	uc003hkm.2	-	7	1632	c.1088G>A	c.(1087-1089)GGA>GAA	p.G363E	CCNI_uc011ccb.1_Missense_Mutation_p.G349E	NM_006835	NP_006826	Q14094	CCNI_HUMAN	cyclin I	363					spermatogenesis					ovary(1)	1						GGAAGCATGTCCCTCTTGTCT	0.418			NA											9	169					0	0	0.008291	0	0
CENPE	1062	broad.mit.edu	37	4	104027379	104027379	+	Nonstop_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr4:104027379C>G	uc003hxb.1	-	49	8196	c.8106G>C	c.(8104-8106)TAG>TAC	p.*2702Y	CENPE_uc003hxc.1_Nonstop_Mutation_p.*2581Y	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2702					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AAAGAGGAGTCTACTGAGTTT	0.468			NA											3	139					0	0	0.009096	0	0
LRIT3	345193	broad.mit.edu	37	4	110790984	110790984	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr4:110790984G>A	uc003hzx.3	+	3	1137	c.944G>A	c.(943-945)AGA>AAA	p.R315K	LRIT3_uc003hzw.3_Missense_Mutation_p.R177K	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	315						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		ACTTCTGAAAGAACTGGAGAT	0.423			NA											5	404					0	0	0.014758	0	0
MAML3	55534	broad.mit.edu	37	4	140641170	140641170	+	Silent	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr4:140641170C>G	uc003ihz.1	-	7	3461	c.2709G>C	c.(2707-2709)GGG>GGC	p.G903G	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Silent_p.G371G	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	904	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					CCATTCCAACCCCCTGCCCAG	0.557			NA											96	356					0	0	0.01441	0	0
C4orf39	152756	broad.mit.edu	37	4	165878524	165878524	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr4:165878524C>G	uc003iqx.1	+	1	425	c.350C>G	c.(349-351)TCA>TGA	p.S117*	TRIM61_uc003iqw.2_Intron	NM_153027	NP_694572	Q96MZ4	CD039_HUMAN	hypothetical protein LOC152756	117											0	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.146)		CACTCCAAGTCAGAAGGACCA	0.567			NA											5	100					0	0	0.001168	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5191834	5191834	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:5191834G>A	uc003jdl.2	+	8	1382	c.1244G>A	c.(1243-1245)CGC>CAC	p.R415H	ADAMTS16_uc003jdk.1_Missense_Mutation_p.R415H|ADAMTS16_uc003jdj.1_Missense_Mutation_p.R415H	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	415	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AGTAAATATCGCAGCTGCACG	0.423			NA											10	305					0	0	0.008291	0	0
CDH12	1010	broad.mit.edu	37	5	22078683	22078683	+	Missense_Mutation	SNP	G	G	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:22078683G>T	uc010iuc.2	-	2	561	c.103C>A	c.(103-105)CCA>ACA	p.P35T	CDH12_uc011cno.1_Missense_Mutation_p.P35T|CDH12_uc003jgk.2_Missense_Mutation_p.P35T	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	35					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TTTTCTCTTGGCTCTGTGGCT	0.458			NA								HNSCC(59;0.17)			10	371					0.00244969	0.0025532	0.020292	1	0
C5orf42	65250	broad.mit.edu	37	5	37169141	37169141	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:37169141G>C	uc011cpa.1	-	34	7216	c.6985C>G	c.(6985-6987)CAA>GAA	p.Q2329E	C5orf42_uc011coy.1_Missense_Mutation_p.Q829E|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.Q1404E|C5orf42_uc003jkr.1_Missense_Mutation_p.Q362E	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2329										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GAGTCCTGTTGAGGTGTCAAA	0.383			NA											5	348					0	0	0.014758	0	0
RGNEF	64283	broad.mit.edu	37	5	73163796	73163796	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:73163796G>A	uc011csq.1	+	18	2259	c.2248G>A	c.(2248-2250)GGA>AGA	p.G750R	RGNEF_uc003kcx.2_Missense_Mutation_p.G750R|RGNEF_uc010izf.2_Missense_Mutation_p.G750R|RGNEF_uc011csr.1_Missense_Mutation_p.G437R	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	750					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		GGAGACTGTGGGACAGGTCCA	0.522			NA											15	35					0	0	0.00499	0	0
DMXL1	1657	broad.mit.edu	37	5	118482991	118482991	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:118482991G>A	uc003ksd.2	+	17	2918	c.2737G>A	c.(2737-2739)GAA>AAA	p.E913K	DMXL1_uc010jcl.1_Missense_Mutation_p.E913K	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	913										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GCAGCCAGAAGAACATTATTC	0.393			NA											5	117					0	0	0.014758	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581561	140581561	+	Silent	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:140581561C>T	uc003liy.2	+	1	2214	c.2214C>T	c.(2212-2214)GAC>GAT	p.D738D	PCDHB11_uc011daj.1_Silent_p.D373D	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	738	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATCTGGTGGACGTGAGCGGCA	0.612			NA											9	264					0	0	0.008291	0	0
DOCK2	1794	broad.mit.edu	37	5	169108878	169108878	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:169108878G>C	uc003maf.2	+	7	681	c.601G>C	c.(601-603)GAA>CAA	p.E201Q	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	201					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TATCAAAGAAGAAATGGTGAG	0.373			NA											3	156					0	0	0.009096	0	0
KCNIP1	30820	broad.mit.edu	37	5	170159839	170159839	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:170159839G>A	uc003mas.2	+	7	1033	c.504G>A	c.(502-504)ATG>ATA	p.M168I	KCNIP1_uc003map.2_Missense_Mutation_p.M166I|KCNIP1_uc003mat.2_Missense_Mutation_p.M157I|KCNIP1_uc010jjp.2_Missense_Mutation_p.M129I|KCNIP1_uc010jjq.2_Missense_Mutation_p.M182I	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	168	EF-hand 3.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTATGACATGATGGGGAAAT	0.488			NA											4	137					0	0	0.014758	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765853	171765853	+	Silent	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:171765853C>T	uc003mbr.2	-	13	2427	c.2256G>A	c.(2254-2256)CAG>CAA	p.Q752Q		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	752	Pro-rich.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGGTCTCTGCTGGGGAGCCT	0.602			NA											18	108					0	0	0.007413	0	0
RNF44	22838	broad.mit.edu	37	5	175959120	175959120	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr5:175959120C>T	uc003mek.1	-	3	707	c.182G>A	c.(181-183)CGA>CAA	p.R61Q	RNF44_uc011dfo.1_5'UTR|RNF44_uc003mel.1_5'Flank	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	61	Pro-rich.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGTGGAGGTCGGGACGGCGG	0.726			NA											3	18					0	0	0.001984	0	0
BTN3A3	10384	broad.mit.edu	37	6	26444280	26444280	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr6:26444280G>A	uc003nhz.2	+	4	361	c.181G>A	c.(181-183)GAG>AAG	p.E61K	BTN3A3_uc003nia.2_Missense_Mutation_p.E19K|BTN3A3_uc011dkn.1_Missense_Mutation_p.E19K	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	61	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0						CATGAGTGCAGAGACCATGGA	0.572			NA											5	252					0	0	0.001168	0	0
STK19	8859	broad.mit.edu	37	6	31940210	31940210	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr6:31940210C>G	uc003nyv.2	+	2	480	c.352C>G	c.(352-354)CTG>GTG	p.L118V	DOM3Z_uc003nyo.1_5'Flank|DOM3Z_uc003nyp.1_5'Flank|DOM3Z_uc003nyq.1_5'Flank|DOM3Z_uc003nyr.1_5'Flank|DOM3Z_uc003nys.1_5'Flank|DOM3Z_uc010jtl.1_5'Flank|STK19_uc003nyt.2_Missense_Mutation_p.L75V|DOM3Z_uc003nyu.1_5'Flank|STK19_uc011dow.1_Missense_Mutation_p.L118V|STK19_uc011dox.1_Missense_Mutation_p.L75V|STK19_uc003nyw.2_Missense_Mutation_p.L118V|STK19_uc010jtn.1_RNA	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	118						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(4)	4						GAGGCATCACCTGATCCCGGA	0.592			NA											4	183					0	0	0.009096	0	0
FILIP1	27145	broad.mit.edu	37	6	76063272	76063272	+	Silent	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr6:76063272C>T	uc003pia.2	-	4	985	c.612G>A	c.(610-612)CTG>CTA	p.L204L	FILIP1_uc003phy.1_Silent_p.L204L|FILIP1_uc003phz.2_Silent_p.L105L|FILIP1_uc010kbe.2_Silent_p.L207L	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	204	Potential.									skin(3)|ovary(1)	4						GCTCCTGCTCCAGCAGGTTGG	0.527			NA											86	312					0	0	0.01441	0	0
AHI1	54806	broad.mit.edu	37	6	135787398	135787398	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr6:135787398C>G	uc003qgi.2	-	7	687	c.303G>C	c.(301-303)TTG>TTC	p.L101F	AHI1_uc003qgh.2_Missense_Mutation_p.L101F|AHI1_uc003qgj.2_Missense_Mutation_p.L101F|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.L101F	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	101						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		GTGTGTTCCTCAATTTGTTTT	0.398			NA											8	416					0	0	0.004482	0	0
NMBR	4829	broad.mit.edu	37	6	142409491	142409491	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr6:142409491G>C	uc003qiu.2	-	1	446	c.305C>G	c.(304-306)TCG>TGG	p.S102W		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	102	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GAAGTAGCGCGAGGCGTCCAC	0.592			NA											4	75					0	0	0.009096	0	0
MLLT4	4301	broad.mit.edu	37	6	168349093	168349093	+	Missense_Mutation	SNP	T	T	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr6:168349093T>C	uc003qwd.2	+	28	3884	c.3742T>C	c.(3742-3744)TGG>CGG	p.W1248R	MLLT4_uc003qwb.1_Missense_Mutation_p.W1233R|MLLT4_uc003qwc.1_Missense_Mutation_p.W1249R|MLLT4_uc003qwg.1_Missense_Mutation_p.W558R	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1249					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TCAGAACCAGTGGCCAAATTA	0.458			NA	T	MLL	AL								4	89					0	0	0.009096	0	0
ABCA13	154664	broad.mit.edu	37	7	48312734	48312734	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:48312734C>G	uc003toq.2	+	17	3496	c.3471C>G	c.(3469-3471)ATC>ATG	p.I1157M	ABCA13_uc010kyr.2_Missense_Mutation_p.I660M	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1157					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GGACTGAAATCTGGGAAACCA	0.363			NA											4	152					0	0	0.014758	0	0
AKAP9	10142	broad.mit.edu	37	7	91709069	91709069	+	Missense_Mutation	SNP	T	T	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:91709069T>C	uc003ulg.2	+	31	7847	c.7622T>C	c.(7621-7623)GTA>GCA	p.V2541A	AKAP9_uc003ulf.2_Missense_Mutation_p.V2533A|AKAP9_uc003uli.2_Missense_Mutation_p.V2164A|AKAP9_uc003ulj.2_Missense_Mutation_p.V311A	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2553	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAGAAGATTGTAAACCTACAG	0.358			NA	T	BRAF	papillary thyroid								3	89					0	0	0.014758	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99631162	99631162	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:99631162G>C	uc003usk.1	+	6	1253	c.1034G>C	c.(1033-1035)AGA>ACA	p.R345T	ZKSCAN1_uc003usl.1_Missense_Mutation_p.R309T|ZKSCAN1_uc003usm.1_Missense_Mutation_p.R132T	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	345					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			ACAGGAGAGAGAGGTCCAAGG	0.483			NA											4	69					0	0	0.009096	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99631261	99631261	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:99631261G>A	uc003usk.1	+	6	1352	c.1133G>A	c.(1132-1134)AGA>AAA	p.R378K	ZKSCAN1_uc003usl.1_Missense_Mutation_p.R342K|ZKSCAN1_uc003usm.1_Missense_Mutation_p.R165K	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	378	C2H2-type 1.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AAGTCTCACAGATGTGATGAA	0.473			NA											6	120					0	0	0.00308	0	0
SLC26A3	1811	broad.mit.edu	37	7	107416986	107416986	+	Missense_Mutation	SNP	A	A	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:107416986A>G	uc003ver.2	-	15	1799	c.1588T>C	c.(1588-1590)TAT>CAT	p.Y530H	SLC26A3_uc003ves.2_Missense_Mutation_p.Y495H	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	530	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TCTGGCTCATACATCTGTAAG	0.378			NA											36	80					0	0	0.00623	0	0
CAPZA2	830	broad.mit.edu	37	7	116546335	116546335	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:116546335G>C	uc003vil.2	+	6	548	c.445G>C	c.(445-447)GAT>CAT	p.D149H	CAPZA2_uc011knk.1_Intron	NM_006136	NP_006127	P47755	CAZA2_HUMAN	capping protein (actin filament) muscle Z-line,	149					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding				0	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)			CAAAAAAATAGATGGACAGCA	0.323			NA											5	100					0	0	0.001984	0	0
KCND2	3751	broad.mit.edu	37	7	119914821	119914821	+	Silent	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:119914821G>C	uc003vjj.1	+	1	1100	c.135G>C	c.(133-135)CTG>CTC	p.L45L		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	45	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TCATTGTGCTGAATGTGAGTG	0.602			NA											8	463					0	0	0.00308	0	0
WDR91	29062	broad.mit.edu	37	7	134896244	134896244	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:134896244G>A	uc003vsp.2	-	1	73	c.11C>T	c.(10-12)GCC>GTC	p.A4V		NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	4										breast(2)|ovary(1)|skin(1)	4						GCGCTCCACGGCCTCCGCCAT	0.706			NA											12	57					0	0	0.003163	0	0
PTN	5764	broad.mit.edu	37	7	136938242	136938242	+	Missense_Mutation	SNP	C	C	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:136938242C>A	uc003vtq.2	-	3	621	c.258G>T	c.(256-258)AAG>AAT	p.K86N	PTN_uc010lmx.2_Missense_Mutation_p.K86N|PTN_uc003vtr.1_Missense_Mutation_p.K86N	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	86					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						TGCAGGGGATCTTACATCTCT	0.502			NA											43	128					2.46787e-29	2.70552e-29	0.01441	1	0
MLL3	58508	broad.mit.edu	37	7	152012354	152012354	+	Silent	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:152012354G>A	uc003wla.2	-	4	678	c.459C>T	c.(457-459)TTC>TTT	p.F153F		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	153					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCGTTATTCTGAATTGTTTTA	0.383	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								5	228					0	0	0.001168	0	0
ESYT2	57488	broad.mit.edu	37	7	158552780	158552780	+	Missense_Mutation	SNP	G	G	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:158552780G>T	uc003wob.1	-	12	1502	c.1436C>A	c.(1435-1437)ACG>AAG	p.T479K	ESYT2_uc003woc.1_Missense_Mutation_p.T303K|ESYT2_uc003wod.1_Missense_Mutation_p.T479K|ESYT2_uc003woa.1_Missense_Mutation_p.T35K	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	507						integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TGGCATTAACGTGAGCCACTC	0.458			NA											20	104					2.70639e-06	2.86104e-06	0.014323	1	0
LRRC67	286187	broad.mit.edu	37	8	67923043	67923043	+	Silent	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr8:67923043G>A	uc003xxc.2	-	5	604	c.459C>T	c.(457-459)ATC>ATT	p.I153I		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	153	LRR 6.										0						TATTATTGCTGATATTCAATA	0.323			NA											5	133					0	0	0.001984	0	0
TRPA1	8989	broad.mit.edu	37	8	72948555	72948555	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr8:72948555G>C	uc003xza.2	-	21	2698	c.2523C>G	c.(2521-2523)TTC>TTG	p.F841L	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	841	Helical; Name=4; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TCATCCAATAGAAGTAAACAG	0.343			NA											3	115					0	0	0.004672	0	0
COL14A1	7373	broad.mit.edu	37	8	121313043	121313043	+	Missense_Mutation	SNP	C	C	G			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr8:121313043C>G	uc003yox.2	+	36	4652	c.4387C>G	c.(4387-4389)CCA>GCA	p.P1463A	COL14A1_uc003yoz.2_Missense_Mutation_p.P428A	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1463	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGCTCTGGGACCAGCGGGCCC	0.408			NA											11	353					0	0	0.010729	0	0
MAF1	84232	broad.mit.edu	37	8	145160793	145160793	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr8:145160793G>C	uc003zbc.1	+	3	606	c.105G>C	c.(103-105)AAG>AAC	p.K35N	SHARPIN_uc003zba.2_5'Flank|SHARPIN_uc003zbb.2_5'Flank|KIAA1875_uc003zbd.3_5'Flank	NM_032272	NP_115648	Q9H063	MAF1_HUMAN	MAF1 protein	35					negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	cytoplasm|nucleus					0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.1e-42)|Epithelial(56;1.23e-40)|all cancers(56;4.84e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACTCATGTAAGATGGCAGGAG	0.562			NA											9	249					0	0	0.006214	0	0
PHKA2	5256	broad.mit.edu	37	X	18926043	18926043	+	Missense_Mutation	SNP	C	C	T			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chrX:18926043C>T	uc004cyv.3	-	22	2922	c.2492G>A	c.(2491-2493)AGG>AAG	p.R831K	PHKA2_uc004cyu.3_Missense_Mutation_p.R129K|PHKA2_uc010nfe.1_5'Flank|PHKA2_uc010nff.1_5'Flank	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	831	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					CACTTTCTTCCTGAGAAGGCC	0.572			NA											9	277					0	0	0.004482	0	0
USP9X	8239	broad.mit.edu	37	X	41073863	41073863	+	Silent	SNP	T	T	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chrX:41073863T>A	uc004dfb.2	+	34	5865	c.5232T>A	c.(5230-5232)ATT>ATA	p.I1744I	USP9X_uc004dfc.2_Silent_p.I1744I	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1744					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						ACGTAGACATTAGAAATCACC	0.308	Ovarian(172;1807 2695 35459 49286)		NA											4	97					0	0	0.014758	0	0
OPHN1	4983	broad.mit.edu	37	X	67430108	67430108	+	Missense_Mutation	SNP	G	G	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chrX:67430108G>A	uc004dww.3	-	9	1013	c.719C>T	c.(718-720)TCC>TTC	p.S240F	OPHN1_uc011mpg.1_Missense_Mutation_p.S240F|OPHN1_uc004dwx.2_Missense_Mutation_p.S240F	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	240					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						CCGGGTACTGGAGAAATGATT	0.333			NA											28	86					0	0	0.004656	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106084060	106084060	+	Silent	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chrX:106084060G>C	uc004emo.2	+	10	1830	c.1665G>C	c.(1663-1665)CTG>CTC	p.L555L	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emn.2_Silent_p.L555L	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	555	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TATCTGCTCTGAGAAGGGTAC	0.448			NA											4	273					0	0	0.009096	0	0
MCF2	4168	broad.mit.edu	37	X	138698557	138698557	+	Missense_Mutation	SNP	C	C	A			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chrX:138698557C>A	uc004fau.2	-	9	1369	c.1075G>T	c.(1075-1077)GCT>TCT	p.A359S	MCF2_uc004fav.2_Missense_Mutation_p.A359S|MCF2_uc011mwl.1_Missense_Mutation_p.A320S|MCF2_uc010nsh.1_Missense_Mutation_p.A359S|MCF2_uc011mwm.1_Missense_Mutation_p.A320S|MCF2_uc011mwn.1_Missense_Mutation_p.A504S|MCF2_uc004faw.2_Missense_Mutation_p.A419S|MCF2_uc011mwo.1_Missense_Mutation_p.A419S	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	359					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GCTTTCTGAGCATCTTCTTTA	0.343			NA											27	141					4.87955e-14	5.27134e-14	0.005443	1	0
MAGEC3	139081	broad.mit.edu	37	X	140983139	140983139	+	Missense_Mutation	SNP	G	G	C			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chrX:140983139G>C	uc011mwp.1	+	5	994	c.994G>C	c.(994-996)GAG>CAG	p.E332Q	MAGEC3_uc004fbs.2_5'UTR|MAGEC3_uc010nsj.2_5'Flank	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	332	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATTTTGCGAGGAGTCTGGACT	0.577			NA											4	240					0	0	0.001168	0	0
C12orf74	338809	broad.mit.edu	37	12	93100418	93100423	+	In_Frame_Del	DEL	CAGAGT	CAGAGT	-			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	CAGAGT	CAGAGT	-	-	CAGAGT	CAGAGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr12:93100418_93100423delCAGAGT	uc001tch.1	+	2	241_246	c.11_16delCAGAGT	c.(10-18)ACAGAGTCA>ACA	p.ES5del	C12orf74_uc001tci.2_In_Frame_Del_p.ES5del	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	5_6											0						ATGGAGAAAACAGAGTCATTCTGTCC	0.529			NA											16	94	---	---	---	---	NA	NA	NA	NA	NA
KHNYN	23351	broad.mit.edu	37	14	24901931	24901931	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr14:24901931delT	uc001wph.3	+	4	1555	c.1353delT	c.(1351-1353)CATfs	p.H451fs	KHNYN_uc010tpc.1_Frame_Shift_Del_p.H492fs|KHNYN_uc010alw.2_Frame_Shift_Del_p.H451fs	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	451										ovary(2)|liver(1)	3						ACTACAGGCATGGCCTCCAGC	0.612			NA									OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	110	---	---	---	---	NA	NA	NA	NA	NA
VPS33B	26276	broad.mit.edu	37	15	91548651	91548653	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	TTC	TTC	-	-	TTC	TTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr15:91548651_91548653delTTC	uc002bqp.1	-	14	1416_1418	c.1062_1064delGAA	c.(1060-1065)AAGAAA>AAA	p.354_355KK>K	VPS33B_uc002bqq.1_In_Frame_Del_p.263_264KK>K|VPS33B_uc010uqu.1_In_Frame_Del_p.327_328KK>K	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	354_355					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CTGCTTGGTTTTCTTCTTCATGA	0.507			NA											15	266	---	---	---	---	NA	NA	NA	NA	NA
ERBB2	2064	broad.mit.edu	37	17	37880981	37880982	+	In_Frame_Ins	INS	-	-	GCATACGTGATG			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr17:37880981_37880982insGCATACGTGATG	uc002hso.2	+	20	2548_2549	c.2310_2311insGCATACGTGATG	c.(2308-2313)insGCATACGTGATG	p.774_775insAYVM	ERBB2_uc002hsm.2_In_Frame_Ins_p.744_745insAYVM|ERBB2_uc010cwa.2_In_Frame_Ins_p.759_760insAYVM|ERBB2_uc002hsp.2_In_Frame_Ins_p.577_578insAYVM|ERBB2_uc010cwb.2_In_Frame_Ins_p.774_775insAYVM|ERBB2_uc010wek.1_In_Frame_Ins_p.498_499insAYVM	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	774_775	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.M774_A775insAYVM(24)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GTCCCCAGGAAGCATACGTGAT	0.594			1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			8	190	---	---	---	---	NA	NA	NA	NA	NA
UXS1	80146	broad.mit.edu	37	2	106713239	106713239	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr2:106713239delC	uc002tdm.2	-	14	1164	c.1066delG	c.(1066-1068)GATfs	p.D356fs	UXS1_uc002tdk.2_Frame_Shift_Del_p.D154fs|UXS1_uc002tdl.2_Frame_Shift_Del_p.D188fs|UXS1_uc002tdn.2_Frame_Shift_Del_p.D361fs|UXS1_uc002tdo.2_Frame_Shift_Del_p.D299fs	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	356	Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						TGTGGGTCATCCTGGGCTTCG	0.473			NA											8	20	---	---	---	---	NA	NA	NA	NA	NA
MEPCE	56257	broad.mit.edu	37	7	100030533	100030551	+	Splice_Site	DEL	TGCCCTCAGGGTAATTATG	TGCCCTCAGGGTAATTATG	-	rs112447917	by1000genomes	TCGA-44-3919-01A-02D-1458-08	TCGA-44-3919-10A-01D-1458-08	TGCCCTCAGGGTAATTATG	TGCCCTCAGGGTAATTATG	-	-	TGCCCTCAGGGTAATTATG	TGCCCTCAGGGTAATTATG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c0fe76a-3407-4e57-8a18-816e849c725d	4ef77426-560d-48fb-9adc-334962565c54	g.chr7:100030533_100030551delTGCCCTCAGGGTAATTATG	uc003uuw.2	+	2	1785	c.1672_splice	c.e2-1	p.G558_splice	MEPCE_uc003uuv.2_Splice_Site_p.G89_splice	NM_019606	NP_062552	Q7L2J0	MEPCE_HUMAN	bin3, bicoid-interacting 3								methyltransferase activity			upper_aerodigestive_tract(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGCCGATTCTTGCCCTCAGGGTAATTATGTGCTGGATCG	0.571			NA											18	277	---	---	---	---	NA	NA	NA	NA	NA
