Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCNN1D	6339	broad.mit.edu	37	1	1221528	1221528	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:1221528G>A	uc001adu.1	+	6	913	c.289G>A	c.(289-291)GTC>ATC	p.V97I	SCNN1D_uc001adt.1_Missense_Mutation_p.V261I|SCNN1D_uc001adw.2_Missense_Mutation_p.V163I|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Missense_Mutation_p.V97I	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GGGAGCCCTGGTCGCGCTCTG	0.692			NA											9	9					0	0	0.006214	0	0
ATAD3C	219293	broad.mit.edu	37	1	1403796	1403796	+	Silent	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:1403796G>C	uc001aft.2	+	12	2117	c.1122G>C	c.(1120-1122)CTG>CTC	p.L374L		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	374							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		ACGGGGTCCTGACCGAGGCCA	0.672			NA											8	31					0	0	0.004482	0	0
UBE4B	10277	broad.mit.edu	37	1	10238755	10238755	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:10238755A>T	uc001aqs.3	+	26	4292	c.3579A>T	c.(3577-3579)GCA>GCT	p.A1193A	UBE4B_uc001aqr.3_Silent_p.A1064A|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.A648A|UBE4B_uc001aqu.2_Silent_p.A74A	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	1193					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TGCGGAAGGCAGGGATCAAAT	0.453			NA											17	53					0	0	0.004007	0	0
NBPF1	55672	broad.mit.edu	37	1	16892902	16892902	+	Splice_Site	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:16892902C>A	uc009vos.1	-	27	4004	c.3116_splice	c.e27+1	p.R1039_splice	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTCAAAGTTACCTGGGGCATG	0.413			NA											7	494					3.07112e-06	3.64235e-06	0.000978	1	0
PLA2G5	5322	broad.mit.edu	37	1	20416375	20416375	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:20416375C>A	uc001bcy.2	+	4	547	c.279C>A	c.(277-279)GGC>GGA	p.G93G	PLA2G5_uc001bcw.2_RNA|PLA2G5_uc001bcx.2_Silent_p.G124G	NM_000929	NP_000920	P39877	PA2G5_HUMAN	phospholipase A2, group V precursor	93					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		TCGCGTGGGGCGTGGTCACCT	0.582			NA											5	40					0.000602214	0.000662548	0.000602	1	0
KIF17	57576	broad.mit.edu	37	1	21044096	21044096	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:21044096G>C	uc001bdr.3	-	1	222	c.104C>G	c.(103-105)GCC>GGC	p.A35G	KIF17_uc001bds.3_Missense_Mutation_p.A35G	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	35	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GCAGCACTGGGCGCGCGCGCA	0.692			NA											18	39					0	0	0.007413	0	0
RUNX3	864	broad.mit.edu	37	1	25291042	25291042	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:25291042G>A	uc009vrj.2	-	2	267	c.21C>T	c.(19-21)TTC>TTT	p.F7F	RUNX3_uc001bjr.2_Silent_p.F7F|RUNX3_uc009vrk.2_Silent_p.F7F|RUNX3_uc009vrl.1_Silent_p.F7F	NM_001031680	NP_001026850	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 1	252	Pro/Ser/Thr-rich.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GGAAGGAGTCGAAGATGCTGT	0.587			NA											5	16					0	0	0.000602	0	0
HPCAL4	51440	broad.mit.edu	37	1	40148339	40148339	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:40148339G>T	uc001cdr.2	-	4	565	c.445C>A	c.(445-447)CAG>AAG	p.Q149K	HPCAL4_uc010oix.1_Missense_Mutation_p.Q77K	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	149	EF-hand 4.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TCCACACGCTGCTGGGGCGTG	0.547			NA											52	129					6.3008e-33	1.11534e-32	0.00361	1	0
CTPS	1503	broad.mit.edu	37	1	41453091	41453091	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:41453091G>T	uc001cgk.3	+	4	893	c.385G>T	c.(385-387)GCG>TCG	p.A129S	CTPS_uc010ojo.1_Intron|CTPS_uc010ojp.1_Missense_Mutation_p.A136S|CTPS_uc001cgl.3_Missense_Mutation_p.A129S|CTPS_uc010ojq.1_5'Flank	NM_001905	NP_001896	P17812	PYRG1_HUMAN	CTP synthase	129					CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)	GATGAGACAGGCGTTAATACC	0.433			NA											22	55					7.07758e-08	8.94884e-08	0.004656	1	0
GPX7	2882	broad.mit.edu	37	1	53073948	53073948	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:53073948G>A	uc001cue.2	+	3	454	c.415G>A	c.(415-417)GAG>AAG	p.E139K		NM_015696	NP_056511	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7 precursor	139					response to oxidative stress	extracellular region	glutathione peroxidase activity				0					Glutathione(DB00143)	TTCTGGGAAGGAGCCCACCTG	0.552			NA											42	107					0	0	0.002522	0	0
CPT2	1376	broad.mit.edu	37	1	53676835	53676835	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:53676835G>T	uc001cvb.3	+	4	2004	c.1489G>T	c.(1489-1491)GGC>TGC	p.G497C		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	497	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)	ATTCAAGCACGGCCGCACTGA	0.617			NA											9	33					3.07112e-06	3.64235e-06	0.000978	1	0
L1TD1	54596	broad.mit.edu	37	1	62675610	62675610	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:62675610T>A	uc001dae.3	+	4	1466	c.1164T>A	c.(1162-1164)GAT>GAA	p.D388E		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	388	Glu-rich.									ovary(1)|skin(1)	2						AGGAGCTGGATGAAGAGGCCT	0.323			NA											31	79					0	0	0.009535	0	0
SGIP1	84251	broad.mit.edu	37	1	67155929	67155929	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:67155929A>T	uc001dcr.2	+	17	1717	c.1500A>T	c.(1498-1500)TTA>TTT	p.L500F	SGIP1_uc010opd.1_Missense_Mutation_p.L100F|SGIP1_uc001dcs.2_Missense_Mutation_p.L100F|SGIP1_uc001dct.2_Missense_Mutation_p.L100F|SGIP1_uc009wat.2_Missense_Mutation_p.L294F	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	500					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TAGCACCCTTAGCGCGGGCTG	0.463			NA											69	170					0	0	0.00361	0	0
AK5	26289	broad.mit.edu	37	1	77987585	77987585	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:77987585G>T	uc001dhn.2	+	12	1642	c.1385G>T	c.(1384-1386)GGC>GTC	p.G462V	AK5_uc001dho.2_Missense_Mutation_p.G436V	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	462	AMP (By similarity).				ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						CTGATTGACGGCTATCCTCGG	0.577			NA											10	30					1.08611e-07	1.36454e-07	0.000978	1	0
ZZZ3	26009	broad.mit.edu	37	1	78047770	78047770	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:78047770C>A	uc001dhq.2	-	7	2162	c.1686G>T	c.(1684-1686)TTG>TTT	p.L562F	ZZZ3_uc001dhr.2_Missense_Mutation_p.L68F|ZZZ3_uc001dhp.2_Missense_Mutation_p.L562F	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						CGATCTCAGGCAATTGAACAA	0.343			NA											33	123					4.32679e-17	6.8058e-17	0.006999	1	0
CLCA4	22802	broad.mit.edu	37	1	87012868	87012868	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:87012868C>A	uc009wcs.2	+	1	110	c.66C>A	c.(64-66)TCC>TCA	p.S22S	CLCA4_uc009wct.2_5'UTR|CLCA4_uc009wcu.2_5'UTR	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	22						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CAAATACTTCCTTCATTAAGC	0.363			NA											29	74					1.75199e-13	2.55893e-13	0.007291	1	0
PTBP2	58155	broad.mit.edu	37	1	97278637	97278637	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:97278637A>T	uc001drq.2	+	13	1687	c.1441A>T	c.(1441-1443)ACT>TCT	p.T481S	PTBP2_uc001drn.2_Missense_Mutation_p.T486S|PTBP2_uc001dro.2_Missense_Mutation_p.T481S|PTBP2_uc010otz.1_Missense_Mutation_p.T497S|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.T429S|PTBP2_uc001drr.2_Missense_Mutation_p.T486S|PTBP2_uc010oua.1_Missense_Mutation_p.T489S|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_Missense_Mutation_p.T100S|PTBP2_uc001drt.2_Missense_Mutation_p.T100S	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	481	RRM 4.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		CACTGGGGGCACTGTGAAAGC	0.333			NA											19	58					0	0	0.010504	0	0
LPPR4	9890	broad.mit.edu	37	1	99771388	99771388	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:99771388A>G	uc001dse.2	+	7	1220	c.1114A>G	c.(1114-1116)ACA>GCA	p.T372A	LPPR4_uc010oue.1_Missense_Mutation_p.T314A	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	372							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AATTGCTCATACAGAAGGCAT	0.468			NA											40	91					0	0	0.002522	0	0
VCAM1	7412	broad.mit.edu	37	1	101190255	101190255	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:101190255G>T	uc001dti.2	+	4	857	c.737G>T	c.(736-738)TGT>TTT	p.C246F	VCAM1_uc001dtj.2_Missense_Mutation_p.C246F|VCAM1_uc010ouj.1_Missense_Mutation_p.C184F	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	246	Ig-like C2-type 3.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	ACCATGACCTGTTCCAGCGAG	0.413			NA											11	35					3.86212e-05	4.4043e-05	0.008291	1	0
COL11A1	1301	broad.mit.edu	37	1	103488398	103488398	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:103488398T>C	uc001dul.2	-	8	1463	c.1145A>G	c.(1144-1146)GAT>GGT	p.D382G	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.D394G|COL11A1_uc001dun.2_Missense_Mutation_p.D343G|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	382	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCATAAAAATCATATTCGCC	0.368			NA											24	81					0	0	0.00278	0	0
SPAG17	200162	broad.mit.edu	37	1	118539080	118539080	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:118539080G>A	uc001ehk.2	-	34	5034	c.4966C>T	c.(4966-4968)CGA>TGA	p.R1656*		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1656						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCACTGTCTCGAAGAAGTTCC	0.358			NA											8	43					0	0	0.004482	0	0
TARS2	80222	broad.mit.edu	37	1	150470105	150470105	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:150470105G>A	uc001euq.2	+	10	1127	c.1120G>A	c.(1120-1122)GAC>AAC	p.D374N	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.D292N|TARS2_uc009wlt.2_5'UTR|TARS2_uc009wls.2_Missense_Mutation_p.D244N	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	374					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TTATCAGGAAGACATGTTTGC	0.547			NA											11	121					0	0	0.008291	0	0
TCHH	7062	broad.mit.edu	37	1	152082789	152082789	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:152082789C>G	uc001ezp.2	-	2	2904	c.2904G>C	c.(2902-2904)CAG>CAC	p.Q968H	TCHH_uc009wne.1_Missense_Mutation_p.Q968H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	968	10 X 30 AA tandem repeats.|4-3.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			gctcttccttctgctgcagct	0.224			NA											29	868					0	0	0.008361	0	0
FLG	2312	broad.mit.edu	37	1	152276900	152276900	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:152276900G>T	uc001ezu.1	-	3	10498	c.10462C>A	c.(10462-10464)CAA>AAA	p.Q3488K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3488	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTACGAGTTTGTCTGCTGGCA	0.557			NA							Ichthyosis				17	913					3.41278e-10	4.5995e-10	0.00499	1	0
IVL	3713	broad.mit.edu	37	1	152882470	152882470	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:152882470C>T	uc001fau.2	+	2	243	c.197C>T	c.(196-198)GCT>GTT	p.A66V		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	66					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACATGACTGCTGTAAAGGGA	0.373			NA											66	89					0	0	0.00361	0	0
IVL	3713	broad.mit.edu	37	1	152882785	152882785	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:152882785G>T	uc001fau.2	+	2	558	c.512G>T	c.(511-513)GGA>GTA	p.G171V		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	171	39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]- [QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD].|2.				isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			cagcaggagggacagctgaag	0.139			NA											20	19					8.00594e-06	9.43841e-06	0.007413	1	0
PGLYRP4	57115	broad.mit.edu	37	1	153303330	153303330	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:153303330C>A	uc001fbo.2	-	9	1100	c.1035G>T	c.(1033-1035)CTG>CTT	p.L345L	PGLYRP4_uc001fbp.2_Silent_p.L341L	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	345					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGTGGCCCACCAGCAGGTAGT	0.552			NA											63	152					2.50483e-33	4.46055e-33	0.00361	1	0
SYT11	23208	broad.mit.edu	37	1	155851156	155851156	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:155851156G>A	uc001fmg.2	+	4	1416	c.1153G>A	c.(1153-1155)GAT>AAT	p.D385N	SYT11_uc010pgq.1_Missense_Mutation_p.D78N	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	385	C2 2.|Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			TATCGACTTCGATCGCACCAC	0.542			NA											38	776					0	0	0.00361	0	0
FCRL5	83416	broad.mit.edu	37	1	157514076	157514076	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:157514076G>T	uc001fqu.2	-	5	978	c.820C>A	c.(820-822)CCG>ACG	p.P274T	FCRL5_uc009wsm.2_Missense_Mutation_p.P274T|FCRL5_uc010phv.1_Missense_Mutation_p.P274T|FCRL5_uc010phw.1_Missense_Mutation_p.P189T|FCRL5_uc001fqv.1_Missense_Mutation_p.P274T|FCRL5_uc010phx.1_Missense_Mutation_p.P25T	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	274	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CAGGATCTCGGGCTGTCAGAT	0.507			NA											168	111					1.52288e-82	2.90376e-82	0.00361	1	0
SPTA1	6708	broad.mit.edu	37	1	158585087	158585087	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:158585087A>T	uc001fst.1	-	48	6906	c.6707T>A	c.(6706-6708)ATT>AAT	p.I2236N		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2236	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGCCAATCCAATGGTGCTGTA	0.532			NA											6	293					0	0	0.001984	0	0
ATP1A2	477	broad.mit.edu	37	1	160104960	160104960	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:160104960G>A	uc001fvc.2	+	15	2122	c.1990G>A	c.(1990-1992)GGC>AGC	p.G664S	ATP1A2_uc001fvb.2_Missense_Mutation_p.G664S|ATP1A2_uc001fvd.2_Missense_Mutation_p.G400S	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	664	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CGTGGTGCACGGCTCTGACCT	0.597			NA											22	104					0	0	0.002299	0	0
SLAMF1	6504	broad.mit.edu	37	1	160604515	160604515	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:160604515G>T	uc001fwl.3	-	3	934	c.588C>A	c.(586-588)CTC>CTA	p.L196L	SLAMF1_uc010pjk.1_RNA|SLAMF1_uc010pjl.1_RNA|SLAMF1_uc010pjm.1_RNA	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	196	Ig-like C2-type.|Extracellular (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GGCCGAGGGTGAGGGACAGGA	0.602			NA											118	59					1.39881e-40	2.56809e-40	0.00361	1	0
NUF2	83540	broad.mit.edu	37	1	163317609	163317609	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:163317609G>C	uc001gcq.1	+	12	1305	c.1005G>C	c.(1003-1005)AAG>AAC	p.K335N	NUF2_uc001gcr.1_Missense_Mutation_p.K335N|NUF2_uc009wvc.1_Missense_Mutation_p.K288N	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	335	Interaction with the N-terminus of NDC80.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					AGAAATTGAAGACTGAAGAAA	0.333			NA											6	47					0	0	0.001984	0	0
F5	2153	broad.mit.edu	37	1	169519136	169519136	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:169519136T>A	uc001ggg.1	-	10	1659	c.1514A>T	c.(1513-1515)TAC>TTC	p.Y505F	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	505	F5/8 type A 2.|Plastocyanin-like 3.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTCACTGTAGTATGGTCTTGT	0.443			NA											29	136					0	0	0.007291	0	0
TNR	7143	broad.mit.edu	37	1	175365895	175365895	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:175365895A>T	uc001gkp.1	-	3	1106	c.1025T>A	c.(1024-1026)ATT>AAT	p.I342N	TNR_uc009wwu.1_Missense_Mutation_p.I342N|TNR_uc010pmz.1_Intron	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	342	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TTCCAGCTCAATGGACCTGTC	0.607			NA											20	145					0	0	0.010504	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563917	176563917	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:176563917G>T	uc001gkz.2	+	3	2341	c.1177G>T	c.(1177-1179)GGT>TGT	p.G393C	PAPPA2_uc001gky.1_Missense_Mutation_p.G393C|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	393					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGACCAGTCTGGTCCCCTGAA	0.592			NA											7	243					1.6384e-10	2.2182e-10	0.001984	1	0
PAPPA2	60676	broad.mit.edu	37	1	176659372	176659372	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:176659372A>T	uc001gkz.2	+	5	3401	c.2237A>T	c.(2236-2238)AAA>ATA	p.K746I	PAPPA2_uc001gky.1_Missense_Mutation_p.K746I|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	746	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CATGTCTTTAAAGGAGTCAGT	0.547			NA											48	267					0	0	0.00361	0	0
PAPPA2	60676	broad.mit.edu	37	1	176709330	176709330	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:176709330G>T	uc001gkz.2	+	14	5313	c.4149G>T	c.(4147-4149)CAG>CAT	p.Q1383H	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1383					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ATCAGGGACAGAGGTACAAAC	0.458			NA											17	46					1.02788e-11	1.4342e-11	0.00499	1	0
PAPPA2	60676	broad.mit.edu	37	1	176734888	176734888	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:176734888G>T	uc001gkz.2	+	15	5402	c.4238G>T	c.(4237-4239)GGC>GTC	p.G1413V	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1413	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ACCTCTATAGGCCCAGGTCTC	0.522			NA											83	267					1.20873e-29	2.11439e-29	0.00361	1	0
CACNA1E	777	broad.mit.edu	37	1	181686252	181686252	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:181686252A>T	uc001gow.2	+	11	1504	c.1339A>T	c.(1339-1341)ATC>TTC	p.I447F	CACNA1E_uc009wxs.2_Missense_Mutation_p.I354F	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	447	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCGAGCCAGTATCAAAAGTGC	0.512			NA											27	139					0	0	0.002096	0	0
CACNA1E	777	broad.mit.edu	37	1	181708286	181708286	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:181708286A>T	uc001gow.2	+	25	3781	c.3616A>T	c.(3616-3618)ATA>TTA	p.I1206L	CACNA1E_uc009wxs.2_Missense_Mutation_p.I1094L|CACNA1E_uc001gox.1_Missense_Mutation_p.I432L|CACNA1E_uc009wxt.2_Missense_Mutation_p.I432L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1206	III.|Helical; Name=S2 of repeat III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCTGCAGATGATAGACCAAGG	0.532			NA											51	233					0	0	0.00361	0	0
ASPM	259266	broad.mit.edu	37	1	197074309	197074309	+	Missense_Mutation	SNP	A	A	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:197074309A>C	uc001gtu.2	-	18	4329	c.4072T>G	c.(4072-4074)TGG>GGG	p.W1358G	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1358	IQ 1.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TATCTTCTCCAATATCCCTGG	0.284			NA											5	16					0	0	0.000602	0	0
CRB1	23418	broad.mit.edu	37	1	197390141	197390141	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:197390141G>A	uc001gtz.2	+	6	1318	c.1183G>A	c.(1183-1185)GAA>AAA	p.E395K	CRB1_uc010poz.1_Missense_Mutation_p.E326K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.E283K|CRB1_uc010ppb.1_Missense_Mutation_p.E395K|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Missense_Mutation_p.E44K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	395	Extracellular (Potential).|EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AATCCACTGCGAAGAAGACGT	0.343			NA											39	182					0	0	0.006999	0	0
GPR25	2848	broad.mit.edu	37	1	200842857	200842857	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:200842857G>A	uc001gvn.1	+	1	692	c.692G>A	c.(691-693)CGG>CAG	p.R231Q		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	231	Cytoplasmic (Potential).					integral to plasma membrane				ovary(1)	1						CGCCTGCGACGGCCGCCGCAC	0.687			NA											4	92					0	0	0.000602	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202406948	202406948	+	Splice_Site	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:202406948G>T	uc001gya.1	+	10	1399	c.1255_splice	c.e10-1	p.F419_splice	PPP1R12B_uc001gxy.2_Splice_Site_p.F419_splice|PPP1R12B_uc009xad.1_Splice_Site_p.F225_splice|PPP1R12B_uc009xae.1_Splice_Site_p.V381_splice|PPP1R12B_uc001gxz.1_Splice_Site_p.F419_splice	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)						regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			TTCTCTCATAGTTCTCTTCTG	0.408			NA											22	77					1.87028e-06	2.24965e-06	0.001882	1	0
KDM5B	10765	broad.mit.edu	37	1	202699059	202699059	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:202699059C>G	uc001gyf.2	-	26	4389	c.4273G>C	c.(4273-4275)GAA>CAA	p.E1425Q	KDM5B_uc009xag.2_Missense_Mutation_p.E1461Q|KDM5B_uc001gyg.1_Missense_Mutation_p.E1267Q	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1425					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TTAACTCGTTCCCACCGCTCA	0.478			NA											160	145					0	0	0.00361	0	0
ADORA1	134	broad.mit.edu	37	1	203134620	203134620	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:203134620C>T	uc001gze.1	+	4	1006	c.573C>T	c.(571-573)CCC>CCT	p.P191P	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Silent_p.P191P|ADORA1_uc010pqg.1_Silent_p.P123P|ADORA1_uc009xak.1_Missense_Mutation_p.P117S|ADORA1_uc010pqh.1_Silent_p.P224P	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	191	Helical; Name=5; (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GGGTGCTGCCCCCGCTTCTCC	0.567			NA											46	152					0	0	0.00361	0	0
NFASC	23114	broad.mit.edu	37	1	204970313	204970313	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:204970313C>A	uc001hbj.2	+	26	3363	c.3035C>A	c.(3034-3036)TCC>TAC	p.S1012Y	NFASC_uc010pra.1_Intron|NFASC_uc001hbi.2_Intron|NFASC_uc010prb.1_Intron|NFASC_uc010prc.1_Intron|NFASC_uc001hbl.1_Intron|NFASC_uc001hbm.1_Intron|NFASC_uc009xbh.1_Intron	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1119	Extracellular (Potential).|Fibronectin type-III 5.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GATGAGCAGTCCATATGGAAC	0.473			NA											10	32					1.33987e-11	1.86512e-11	0.008291	1	0
C1orf65	164127	broad.mit.edu	37	1	223567913	223567913	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:223567913G>T	uc001hoa.2	+	1	1199	c.1096G>T	c.(1096-1098)GCC>TCC	p.A366S		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	366	Potential.									central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		GAAGGCGCGCGCCCAGGCAGA	0.672			NA											23	17					1.28384e-07	1.60277e-07	0.001882	1	0
EPHX1	2052	broad.mit.edu	37	1	226016497	226016497	+	Missense_Mutation	SNP	A	A	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:226016497A>C	uc001hpk.2	+	2	147	c.67A>C	c.(67-69)AAA>CAA	p.K23Q	EPHX1_uc001hpl.2_Missense_Mutation_p.K23Q	NM_001136018	NP_001129490	P07099	HYEP_HUMAN	epoxide hydrolase 1	23					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			ovary(3)|lung(1)	4	Breast(184;0.197)					CTCCCGGGACAAAGAGGAAAC	0.562			NA											25	33					0	0	0.003954	0	0
ACTN2	88	broad.mit.edu	37	1	236902645	236902645	+	Missense_Mutation	SNP	G	G	T	rs112882610		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:236902645G>T	uc001hyf.2	+	10	1124	c.920G>T	c.(919-921)CGG>CTG	p.R307L	ACTN2_uc001hyg.2_Missense_Mutation_p.R99L|ACTN2_uc009xgi.1_Missense_Mutation_p.R307L|ACTN2_uc010pxu.1_Intron|ACTN2_uc001hyh.2_5'UTR	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	307	Spectrin 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CTGGAGAACCGGACTCCCGAG	0.567			NA											98	94					2.608e-42	4.80293e-42	0.00361	1	0
NLRP3	114548	broad.mit.edu	37	1	247607348	247607348	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:247607348C>A	uc001icr.2	+	9	2882	c.2744C>A	c.(2743-2745)ACG>AAG	p.T915K	NLRP3_uc001ics.2_Missense_Mutation_p.T858K|NLRP3_uc001icu.2_Missense_Mutation_p.T915K|NLRP3_uc001icw.2_Missense_Mutation_p.T858K|NLRP3_uc001icv.2_Missense_Mutation_p.T801K|NLRP3_uc010pyw.1_Missense_Mutation_p.T893K	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	915	LRR 7.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGAATCTCACGCACCTTTAC	0.512			NA											43	75					4.17593e-13	6.05459e-13	0.007835	1	0
OR2B11	127623	broad.mit.edu	37	1	247614966	247614966	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:247614966C>A	uc010pyx.1	-	1	319	c.319G>T	c.(319-321)GTC>TTC	p.V107F		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CAGTGGAAGACTGCATATTGC	0.592			NA											70	74					1.48072e-28	2.56744e-28	0.00361	1	0
C1orf150	148823	broad.mit.edu	37	1	247737611	247737611	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:247737611T>C	uc001idf.2	+	5	380	c.335T>C	c.(334-336)CTT>CCT	p.L112P	C1orf150_uc009xgw.2_RNA|C1orf150_uc001ida.3_RNA|C1orf150_uc001idb.3_RNA|C1orf150_uc009xgx.2_RNA	NM_145278	NP_660321	Q5JQS6	CA150_HUMAN	hypothetical protein LOC148823	112											0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GAATATGCCCTTCTTAGGACT	0.443			NA											35	107					0	0	0.002836	0	0
C10orf47	254427	broad.mit.edu	37	10	11908754	11908754	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:11908754G>A	uc001ikx.2	+	3	517	c.363G>A	c.(361-363)GAG>GAA	p.E121E	uc001iky.1_Intron	NM_153256	NP_694988	Q86WR7	CJ047_HUMAN	hypothetical protein LOC254427	121										central_nervous_system(1)	1						GGGAAGCCGAGGGCCTTCCAG	0.622			NA											29	62					0	0	0.00874	0	0
MSRB2	22921	broad.mit.edu	37	10	23409753	23409753	+	Missense_Mutation	SNP	A	A	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:23409753A>C	uc001iro.2	+	5	622	c.511A>C	c.(511-513)AAC>CAC	p.N171H		NM_012228	NP_036360	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2 precursor	171					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0					L-Methionine(DB00134)	GTTTTGCATCAACAGTGTGGC	0.493	Esophageal Squamous(89;1240 1363 4973 30188 42299)		NA											17	39					0	0	0.006122	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317504	30317504	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:30317504G>A	uc001iux.2	-	2	1632	c.1573C>T	c.(1573-1575)CAG>TAG	p.Q525*	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Nonsense_Mutation_p.Q387*|KIAA1462_uc009xle.1_Nonsense_Mutation_p.Q525*	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	525										ovary(4)	4						TCAGGCCACTGTCCCCTTGCC	0.632			NA											81	186					0	0	0.00361	0	0
EPC1	80314	broad.mit.edu	37	10	32573907	32573907	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:32573907G>A	uc001iwg.1	-	10	1733	c.1463C>T	c.(1462-1464)TCA>TTA	p.S488L	EPC1_uc001iwi.3_Missense_Mutation_p.S438L|EPC1_uc009xlt.2_Missense_Mutation_p.S438L|EPC1_uc001iwh.1_Missense_Mutation_p.S488L	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	488					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				ATGTTGTGGTGAGGAAAGCAT	0.388			NA											30	108					0	0	0.007291	0	0
AGAP6	414189	broad.mit.edu	37	10	51768660	51768660	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:51768660G>T	uc001jix.3	+	8	1173	c.775G>T	c.(775-777)GGG>TGG	p.G259W		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	259					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						ATCTGAGAAAGGGAGTGACCC	0.562			NA											87	233					7.79638e-53	1.4677e-52	0.00361	1	0
ANK3	288	broad.mit.edu	37	10	61833765	61833765	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:61833765C>A	uc001jky.2	-	37	7066	c.6874G>T	c.(6874-6876)GGT>TGT	p.G2292C	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2292					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCAAACAGACCTGCCAGTTCT	0.493			NA											44	127					2.56175e-15	3.90518e-15	0.00361	1	0
LRRTM3	347731	broad.mit.edu	37	10	68857483	68857483	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:68857483G>T	uc001jmz.1	+	3	2225	c.1675G>T	c.(1675-1677)GAG>TAG	p.E559*	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	559	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						AACACACCTAGAGACTGAGCT	0.483			NA											13	33					2.27111e-07	2.82341e-07	0.001368	1	0
MAT1A	4143	broad.mit.edu	37	10	82036276	82036276	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:82036276C>A	uc001kbw.2	-	6	879	c.624G>T	c.(622-624)CAG>CAT	p.Q208H		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	208					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CTTCGTTGTGCTGCACAGAGA	0.582			NA											43	173					9.84934e-19	1.59146e-18	0.002522	1	0
AGAP11	119385	broad.mit.edu	37	10	88769369	88769369	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:88769369C>G	uc001kee.2	+	12	2564	c.1360C>G	c.(1360-1362)CAC>GAC	p.H454D	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	454					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CCTGGGCCAGCACCTGCTGCG	0.607			NA											43	126					0	0	0.002522	0	0
AS3MT	57412	broad.mit.edu	37	10	104638636	104638636	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:104638636G>C	uc001kwk.2	+	9	913	c.773G>C	c.(772-774)CGC>CCC	p.R258P	AS3MT_uc001kwj.2_Missense_Mutation_p.R260P|AS3MT_uc009xxh.2_Missense_Mutation_p.R258P	NM_020682	NP_065733	Q9HBK9	AS3MT_HUMAN	arsenic (+3 oxidation state) methyltransferase	258					arsonoacetate metabolic process|toxin metabolic process	cytosol	arsenite methyltransferase activity|methylarsonite methyltransferase activity				0		Colorectal(252;0.122)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;5.87e-09)|all cancers(201;1.58e-07)|BRCA - Breast invasive adenocarcinoma(275;0.223)		GCAACATTTCGCCTCTTCAAA	0.413			NA											25	95					0	0	0.00333	0	0
ACSL5	51703	broad.mit.edu	37	10	114169302	114169302	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:114169302G>T	uc001kzs.2	+	7	711	c.570G>T	c.(568-570)AAG>AAT	p.K190N	ACSL5_uc001kzt.2_Missense_Mutation_p.K190N|ACSL5_uc001kzu.2_Missense_Mutation_p.K246N|ACSL5_uc009xxz.2_Missense_Mutation_p.K190N|ACSL5_uc010qrj.1_Translation_Start_Site	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	190	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		CACCCCAAAAGGCATTGGTGC	0.498			NA											46	118					5.73435e-26	9.88508e-26	0.00361	1	0
GRK5	2869	broad.mit.edu	37	10	121140407	121140407	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:121140407C>A	uc001led.2	+	3	462	c.229C>A	c.(229-231)CTG>ATG	p.L77M	GRK5_uc009xzh.2_Translation_Start_Site|GRK5_uc010qta.1_Translation_Start_Site	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	77	N-terminal.|RGS.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		CAGGCCTGGGCTGGAGTGTTA	0.498			NA											45	128					7.88023e-25	1.34668e-24	0.00361	1	0
CPXM2	119587	broad.mit.edu	37	10	125521438	125521438	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:125521438T>A	uc001lhk.1	-	11	2052	c.1727A>T	c.(1726-1728)CAG>CTG	p.Q576L	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	576					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CTCCTCCTTCTGGAAGTCCTC	0.667			NA											19	38					0	0	0.006122	0	0
DOCK1	1793	broad.mit.edu	37	10	128830475	128830475	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr10:128830475G>C	uc001ljt.2	+	18	1804	c.1740G>C	c.(1738-1740)AAG>AAC	p.K580N	DOCK1_uc010qun.1_Missense_Mutation_p.K601N	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	580	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TGGAAGAAAAGGGCCACTCGG	0.557			NA											3	9					0	0	0.004672	0	0
LSP1	4046	broad.mit.edu	37	11	1904695	1904695	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:1904695C>A	uc001lui.2	+	4	578	c.403C>A	c.(403-405)CTG>ATG	p.L135M	LSP1_uc001luj.2_Missense_Mutation_p.L263M|LSP1_uc001luk.2_Missense_Mutation_p.L73M|LSP1_uc001lul.2_Missense_Mutation_p.L73M|LSP1_uc001lum.2_Missense_Mutation_p.L73M	NM_002339	NP_002330	P33241	LSP1_HUMAN	lymphocyte-specific protein 1 isoform 1	135					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			large_intestine(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		TGAAGTCCACCTGGAGGAGTT	0.607			NA											13	84					7.93312e-07	9.76004e-07	0.00245	1	0
TSPAN32	10077	broad.mit.edu	37	11	2337896	2337896	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:2337896C>A	uc001lvy.1	+	8	855	c.718C>A	c.(718-720)CGA>AGA	p.R240R	TSPAN32_uc010qxk.1_3'UTR|TSPAN32_uc009ydl.1_RNA|TSPAN32_uc001lvz.1_Silent_p.R210R|TSPAN32_uc001lwb.1_Missense_Mutation_p.R210S|TSPAN32_uc001lwc.1_Silent_p.R185R|TSPAN32_uc001lwd.1_Silent_p.R172R	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	240					cell-cell signaling	integral to membrane		p.R240*(1)		central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		CCTGACCCCACGGTAGGGCCC	0.657			NA											15	49					0.000566183	0.000627564	0.00499	1	0
OR52B4	143496	broad.mit.edu	37	11	4389468	4389468	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:4389468G>A	uc010qye.1	-	1	58	c.58C>T	c.(58-60)CCT>TCT	p.P20S		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTAGGCCAGGGATGCCCAGC	0.512			NA											13	26					0	0	0.004007	0	0
OR51F2	119694	broad.mit.edu	37	11	4842710	4842710	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:4842710C>A	uc010qyn.1	+	1	95	c.95C>A	c.(94-96)CCA>CAA	p.P32Q		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	32	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGGCATTCCAGGCCTGAAA	0.473			NA											69	183					1.42676e-28	2.48114e-28	0.00361	1	0
MMP26	56547	broad.mit.edu	37	11	5011855	5011855	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:5011855G>A	uc001lzv.2	+	3	366	c.348G>A	c.(346-348)AAG>AAA	p.K116K		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	116					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		ATGATATGAAGCCATCCGCAG	0.388			NA											20	68					0	0	0.010504	0	0
OR6A2	8590	broad.mit.edu	37	11	6816036	6816036	+	Missense_Mutation	SNP	C	C	A	rs146813493	byFrequency	TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:6816036C>A	uc001mes.1	-	1	1104	c.904G>T	c.(904-906)GTC>TTC	p.V302F		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCTCTCTTGACCTCTTGATTG	0.473			NA											27	93					8.24728e-16	1.2736e-15	0.004656	1	0
OVCH2	341277	broad.mit.edu	37	11	7716867	7716867	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:7716867C>A	uc010rbf.1	-	12	1216	c.1216G>T	c.(1216-1218)GAT>TAT	p.D406Y		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		TCTGTGGCATCAGAGACGAAT	0.264			NA											11	48					0.00829132	0.00889105	0.008291	1	0
INSC	387755	broad.mit.edu	37	11	15260554	15260554	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:15260554G>T	uc001mly.2	+	11	1514	c.1468G>T	c.(1468-1470)GCT>TCT	p.A490S	INSC_uc001mlz.2_Missense_Mutation_p.A443S|INSC_uc001mma.2_Missense_Mutation_p.A443S|INSC_uc010rcs.1_Missense_Mutation_p.A478S|INSC_uc001mmb.2_Missense_Mutation_p.A443S|INSC_uc001mmc.2_Missense_Mutation_p.A401S	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	490					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CCAGCAGAAAGCTGCAGTGAC	0.602			NA											15	45					8.28177e-16	1.27561e-15	0.007413	1	0
HPS5	11234	broad.mit.edu	37	11	18301447	18301447	+	Silent	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:18301447G>C	uc001mod.1	-	23	3650	c.3372C>G	c.(3370-3372)CTC>CTG	p.L1124L	HPS5_uc001moe.1_Silent_p.L1010L|HPS5_uc001mof.1_Silent_p.L1010L	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	1124						cytosol				ovary(1)|pancreas(1)|skin(1)	3						GCTGGGACCAGAGAAACCGAT	0.403			NA							Hermansky-Pudlak_syndrome				14	47					0	0	0.003163	0	0
LDHA	3939	broad.mit.edu	37	11	18425271	18425271	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:18425271G>C	uc001mok.3	+	6	895	c.623G>C	c.(622-624)GGT>GCT	p.G208A	LDHA_uc010rdc.1_Missense_Mutation_p.G150A|LDHA_uc009yhn.2_Missense_Mutation_p.G207A|LDHA_uc009yho.2_Missense_Mutation_p.G35A|LDHA_uc001mol.3_Missense_Mutation_p.G208A|LDHA_uc010rdd.1_Missense_Mutation_p.G237A	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	208					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	AATGTTGCTGGTGTCTCTCTG	0.378			NA											3	201					0	0	0.009096	0	0
NELL1	4745	broad.mit.edu	37	11	21592424	21592424	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:21592424G>T	uc001mqe.2	+	18	2248	c.2095G>T	c.(2095-2097)GGT>TGT	p.G699C	NELL1_uc001mqf.2_Missense_Mutation_p.G652C|NELL1_uc009yid.2_Missense_Mutation_p.G727C|NELL1_uc010rdo.1_Missense_Mutation_p.G642C|NELL1_uc010rdp.1_Missense_Mutation_p.G412C|NELL1_uc001mqh.2_Missense_Mutation_p.G244C	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	699	VWFC 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						AGACCAAAATGGTCACAAGCT	0.473			NA											32	59					9.65021e-13	1.38561e-12	0.002096	1	0
KCNA4	3739	broad.mit.edu	37	11	30033978	30033978	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:30033978C>T	uc001msk.2	-	2	1400	c.248G>A	c.(247-249)CGG>CAG	p.R83Q		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	83						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCTCCTCCTCCGACTACCCCG	0.637			NA											28	80					0	0	0.005443	0	0
KCNA4	3739	broad.mit.edu	37	11	30034116	30034116	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:30034116C>A	uc001msk.2	-	2	1262	c.110G>T	c.(109-111)AGG>ATG	p.R37M		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	37						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGCAGCTGCCCTGGAGTGAGC	0.667			NA											14	45					1.40151e-16	2.18135e-16	0.010504	1	0
MPPED2	744	broad.mit.edu	37	11	30433103	30433103	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:30433103G>A	uc001msr.2	-	6	917	c.797C>T	c.(796-798)ACG>ATG	p.T266M	MPPED2_uc001msq.3_Intron|MPPED2_uc009yji.2_Missense_Mutation_p.T140M	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	266					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						ATTGATGTACGTTGTGTAACC	0.463			NA											19	41					0	0	0.010504	0	0
MPPED2	744	broad.mit.edu	37	11	30435814	30435814	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:30435814C>A	uc001msr.2	-	5	847	c.727G>T	c.(727-729)GTC>TTC	p.V243F	MPPED2_uc001msq.3_Missense_Mutation_p.V243F|MPPED2_uc009yji.2_Missense_Mutation_p.V117F	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	243					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						TTGGGCCGGACTCGCCTCTGA	0.473			NA											8	53					1.12685e-05	1.31281e-05	0.004482	1	0
OR4C46	119749	broad.mit.edu	37	11	51515976	51515976	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:51515976A>T	uc010ric.1	+	1	695	c.695A>T	c.(694-696)CAC>CTC	p.H232L		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGGCAAGGCACAAAGCCCTC	0.483			NA											30	56					0	0	0.002096	0	0
OR5F1	338674	broad.mit.edu	37	11	55761670	55761670	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:55761670C>A	uc010riv.1	-	1	432	c.432G>T	c.(430-432)ATG>ATT	p.M144I		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CCCCGGCTGCCATTTTTAGGT	0.498			NA											18	31					6.49762e-13	9.37491e-13	0.006122	1	0
OR8J1	219477	broad.mit.edu	37	11	56128508	56128508	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:56128508C>A	uc010rjh.1	+	1	786	c.786C>A	c.(784-786)CCC>CCA	p.P262P		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATGTGCAGCCCCGAAGTAACC	0.408			NA											24	84					1.13719e-10	1.54668e-10	0.008361	1	0
OR5M8	219484	broad.mit.edu	37	11	56258462	56258462	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:56258462G>T	uc001nix.1	-	1	385	c.385C>A	c.(385-387)CTG>ATG	p.L129M		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CCATAAAGCAGAGGGTTGCAG	0.517			NA											18	51					1.85244e-09	2.43569e-09	0.00333	1	0
OR5M10	390167	broad.mit.edu	37	11	56344907	56344907	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:56344907G>T	uc001niz.1	-	1	291	c.291C>A	c.(289-291)TGC>TGA	p.C97*		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTGTGTGAAGCATCCAGCGT	0.443			NA											24	69					1.64293e-13	2.40558e-13	0.00333	1	0
OR9Q1	219956	broad.mit.edu	37	11	57947485	57947485	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:57947485G>T	uc001nmj.2	+	3	885	c.569G>T	c.(568-570)GGG>GTG	p.G190V		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TTGACCTGTGGGGAGAGCTAC	0.463			NA											32	116					1.08312e-15	1.65966e-15	0.009535	1	0
OR10W1	81341	broad.mit.edu	37	11	58034677	58034677	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:58034677C>G	uc001nmq.1	-	1	1056	c.654G>C	c.(652-654)AAG>AAC	p.K218N		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	218	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				CCGAGTGGATCTTGAGCAGAG	0.572			NA											13	27					0	0	0.003163	0	0
DTX4	23220	broad.mit.edu	37	11	58949495	58949495	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:58949495A>T	uc001nns.2	+	2	752	c.495A>T	c.(493-495)ACA>ACT	p.T165T	DTX4_uc001nnr.2_Silent_p.T59T	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	165					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				CCATGGTCACAGGGACCTTGC	0.637			NA											21	68					0	0	0.002299	0	0
LRRC32	2615	broad.mit.edu	37	11	76371973	76371973	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:76371973C>A	uc001oxq.3	-	3	907	c.664G>T	c.(664-666)GTG>TTG	p.V222L	LRRC32_uc001oxr.3_Missense_Mutation_p.V222L|LRRC32_uc010rsf.1_Missense_Mutation_p.V222L	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	222	LRR 8.|Extracellular (Potential).					integral to plasma membrane					0						AGGTCTAGCACCCGCAGCTGC	0.622			NA											28	60					3.62531e-18	5.79463e-18	0.004289	1	0
PCF11	51585	broad.mit.edu	37	11	82879556	82879556	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:82879556G>C	uc001ozx.3	+	8	2524	c.2179G>C	c.(2179-2181)GAT>CAT	p.D727H	PCF11_uc010rsu.1_Missense_Mutation_p.D858H	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	727	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ACCATTTGTAGATAGTCCAGC	0.428			NA											24	43					0	0	0.00278	0	0
MMP3	4314	broad.mit.edu	37	11	102713485	102713485	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:102713485G>A	uc001phj.1	-	2	333	c.268C>T	c.(268-270)CCC>TCC	p.P90S		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	90	Cysteine switch (By similarity).				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CCACACCTGGGCTTGCGCATC	0.512			NA											9	8					0	0	0.004482	0	0
DLAT	1737	broad.mit.edu	37	11	111896296	111896296	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:111896296G>A	uc001pmo.2	+	1	759	c.100G>A	c.(100-102)GTG>ATG	p.V34M	DLAT_uc009yyk.1_Missense_Mutation_p.V34M|DLAT_uc010rwr.1_Missense_Mutation_p.V34M	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	34					glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	AACTCCACGAGTGACCTCGCG	0.682			NA											9	35					0	0	0.006214	0	0
USP28	57646	broad.mit.edu	37	11	113699991	113699991	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:113699991A>T	uc001poh.2	-	10	1020	c.987T>A	c.(985-987)TGT>TGA	p.C329*	USP28_uc001pog.2_Nonsense_Mutation_p.C37*|USP28_uc010rwy.1_Nonsense_Mutation_p.C204*|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Nonsense_Mutation_p.C329*	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	329					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CCCCTTCCAAACACTCGTCTA	0.468	Melanoma(4;162 555 7664)|GBM(79;500 2010 17506)|Esophageal Squamous(9;463 924 15765)		NA											18	41					0	0	0.006122	0	0
SIDT2	51092	broad.mit.edu	37	11	117058369	117058369	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:117058369T>A	uc001pqh.1	+	12	1154	c.1113T>A	c.(1111-1113)GGT>GGA	p.G371G	SIDT2_uc010rxe.1_Silent_p.G371G|SIDT2_uc001pqg.2_Silent_p.G371G|SIDT2_uc001pqi.1_Silent_p.G375G	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	371	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		CTACCGATGGTCTGGTTGACA	0.612			NA											31	72					0	0	0.00623	0	0
OR6X1	390260	broad.mit.edu	37	11	123624331	123624331	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:123624331A>G	uc010rzy.1	-	1	896	c.896T>C	c.(895-897)TTA>TCA	p.L299S		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGCCTTTCTTAAGGCTCCCTT	0.378			NA											58	117					0	0	0.00361	0	0
OR8B4	283162	broad.mit.edu	37	11	124294273	124294273	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:124294273C>A	uc010sak.1	-	1	495	c.495G>T	c.(493-495)CTG>CTT	p.L165L		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CACAGAAGGTCAGTCGCAGCA	0.532			NA											14	19					2.31682e-05	2.67291e-05	0.003163	1	0
KIRREL3	84623	broad.mit.edu	37	11	126316711	126316711	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:126316711G>T	uc001qea.2	-	9	1429	c.1068C>A	c.(1066-1068)TGC>TGA	p.C356*	KIRREL3_uc001qeb.2_Nonsense_Mutation_p.C356*|KIRREL3_uc001qec.1_Nonsense_Mutation_p.C356*	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	356	Extracellular (Potential).|Ig-like C2-type 4.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CGGTCCAGGCGCAGCTGAAGA	0.627			NA											3	5					0.004672	0.00501901	0.004672	1	0
ARHGAP32	9743	broad.mit.edu	37	11	128842434	128842434	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:128842434G>A	uc009zcp.2	-	21	3925	c.3925C>T	c.(3925-3927)CCG>TCG	p.P1309S	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.P268S|ARHGAP32_uc001qez.2_Missense_Mutation_p.P960S	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1309	Poly-Pro.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TGGGAAGGCGGAGGGGGAAGG	0.537			NA											35	80					0	0	0.004289	0	0
KCNA1	3736	broad.mit.edu	37	12	5021590	5021590	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:5021590C>A	uc001qnh.2	+	2	2151	c.1046C>A	c.(1045-1047)GCG>GAG	p.A349E		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	349					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTTGCCGAGGCGGAAGAAGCT	0.532			NA											80	238					6.00396e-56	1.13749e-55	0.00361	1	0
CHD4	1108	broad.mit.edu	37	12	6709107	6709107	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:6709107C>A	uc001qpo.2	-	10	1478	c.1314G>T	c.(1312-1314)GGG>GGT	p.G438G	CHD4_uc001qpn.2_Silent_p.G431G|CHD4_uc001qpp.2_Silent_p.G435G	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	438					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CGAGGTCTCCCCCAACCTCTT	0.522	Colon(32;586 792 4568 16848 45314)		NA											137	379					1.35588e-38	2.48159e-38	0.00361	1	0
CD163	9332	broad.mit.edu	37	12	7647772	7647772	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:7647772C>A	uc001qsz.3	-	6	1453	c.1325G>T	c.(1324-1326)TGT>TTT	p.C442F	CD163_uc001qta.3_Missense_Mutation_p.C442F|CD163_uc009zfw.2_Missense_Mutation_p.C442F	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	442	SRCR 4.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ATTTCCGTTACAGCTACTTAG	0.448			NA											68	170					2.18329e-32	3.84181e-32	0.00361	1	0
PZP	5858	broad.mit.edu	37	12	9333633	9333633	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:9333633A>T	uc001qvl.2	-	15	1814	c.1785T>A	c.(1783-1785)GCT>GCA	p.A595A	PZP_uc009zgl.2_Silent_p.A464A	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTTGGTCCACAGCACGAAGGG	0.592	Melanoma(125;1402 1695 4685 34487 38571)		NA											13	26					0	0	0.001855	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18491482	18491482	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:18491482G>T	uc001rdt.2	+	9	1511	c.1395G>T	c.(1393-1395)GAG>GAT	p.E465D	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.E465D|PIK3C2G_uc010sic.1_Missense_Mutation_p.E243D	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	465					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GAAAAGGAGAGGTAAGTACAT	0.299			NA											16	44					1.56452e-12	2.22485e-12	0.007413	1	0
CMAS	55907	broad.mit.edu	37	12	22208545	22208545	+	Splice_Site	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:22208545G>T	uc001rfm.2	+	3	638	c.559_splice	c.e3+1	p.V187_splice	CMAS_uc001rfn.2_Splice_Site	NM_018686	NP_061156	Q8NFW8	NEUA_HUMAN	cytidine monophospho-N-acetylneuraminic acid						lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3						CAGAAAGGAGGTAATCTCTTT	0.343			NA											18	34					3.51602e-12	4.95249e-12	0.008871	1	0
OVCH1	341350	broad.mit.edu	37	12	29597135	29597135	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:29597135A>T	uc001rix.1	-	24	2960	c.2960T>A	c.(2959-2961)CTG>CAG	p.L987Q		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	987					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGGCTTGGTCAGAAGAACATC	0.418			NA											24	66					0	0	0.002299	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30882156	30882156	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:30882156C>T	uc001rji.1	-	8	1959	c.1208G>A	c.(1207-1209)CGT>CAT	p.R403H	CAPRIN2_uc001rjf.1_Missense_Mutation_p.R200H|CAPRIN2_uc001rjg.1_Missense_Mutation_p.R70H|CAPRIN2_uc001rjh.1_Missense_Mutation_p.R403H|CAPRIN2_uc001rjj.1_Missense_Mutation_p.R70H|CAPRIN2_uc001rjk.3_Missense_Mutation_p.R403H|CAPRIN2_uc001rjl.3_Missense_Mutation_p.R403H|CAPRIN2_uc001rjm.1_Missense_Mutation_p.R70H|CAPRIN2_uc001rjn.1_Missense_Mutation_p.R70H	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	403					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CATATCCCAACGTTTTGGGAG	0.443			NA											28	85					0	0	0.008361	0	0
KIF21A	55605	broad.mit.edu	37	12	39761735	39761735	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:39761735C>A	uc001rly.2	-	4	696	c.550G>T	c.(550-552)GGA>TGA	p.G184*	KIF21A_uc001rlx.2_Nonsense_Mutation_p.G184*|KIF21A_uc001rlz.2_Nonsense_Mutation_p.G184*|KIF21A_uc010skl.1_Nonsense_Mutation_p.G184*|KIF21A_uc001rma.1_Nonsense_Mutation_p.G184*	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	184	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				GTATAAATTCCTCCAGTTGAA	0.308			NA											21	46					7.16444e-05	8.12335e-05	0.003954	1	0
VDR	7421	broad.mit.edu	37	12	48238559	48238559	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:48238559C>A	uc001rqm.2	-	11	1536	c.1254G>T	c.(1252-1254)GTG>GTT	p.V418V	VDR_uc001rql.2_Silent_p.V468V|VDR_uc001rqn.2_Silent_p.V418V|VDR_uc010slq.1_Silent_p.V386V	NM_001017535	NP_001017535	P11473	VDR_HUMAN	vitamin D (1,25-dihydroxyvitamin D3) receptor	418	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	ACACTTCGAGCACAAGGGGCG	0.632			NA											31	94					4.31634e-10	5.80405e-10	0.002445	1	0
WNT1	7471	broad.mit.edu	37	12	49373354	49373354	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:49373354C>A	uc001rsu.2	+	2	406	c.208C>A	c.(208-210)CGT>AGT	p.R70S		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	70					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		CAAACAGCGGCGTCTGATACG	0.592			NA											35	118					1.62957e-23	2.74527e-23	0.00874	1	0
KRT75	9119	broad.mit.edu	37	12	52827967	52827967	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:52827967G>T	uc001saj.2	-	1	144	c.122C>A	c.(121-123)GCA>GAA	p.A41E		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	41	Gly-rich.|Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		ACTCCCTGCTGCAGAGCGGGC	0.667			NA											13	58					4.36969e-10	5.84927e-10	0.001855	1	0
KRT3	3850	broad.mit.edu	37	12	53189613	53189613	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:53189613C>A	uc001say.2	-	1	280	c.214G>T	c.(214-216)GCT>TCT	p.A72S		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	72	Gly-rich.|Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						GAGCCGCCAGCTGCCACGCTG	0.507			NA											35	101					4.01765e-15	6.09327e-15	0.009718	1	0
CSAD	51380	broad.mit.edu	37	12	53555112	53555112	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:53555112G>T	uc001sby.2	-	10	890	c.764C>A	c.(763-765)CCC>CAC	p.P255H	CSAD_uc001sbw.2_Missense_Mutation_p.P108H|CSAD_uc009zmt.2_Missense_Mutation_p.P37H|CSAD_uc010snx.1_Missense_Mutation_p.P282H|CSAD_uc001sbz.2_Missense_Mutation_p.P255H|CSAD_uc009zmu.2_Missense_Mutation_p.P108H|CSAD_uc001sca.3_RNA	NM_015989	NP_057073	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	255					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			ovary(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TGCCTCCAGGGGGTCAAAGGC	0.587	Ovarian(109;252 1546 16882 28524 44645)		NA							Hereditary_Prostate_Cancer				5	202					0.00198382	0.00215854	0.001984	1	0
OR6C74	254783	broad.mit.edu	37	12	55641435	55641435	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:55641435G>T	uc010spg.1	+	1	364	c.364G>T	c.(364-366)GTG>TTG	p.V122L		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TGAGCGCTATGTGGCCATCTG	0.463			NA											57	137					2.67592e-24	4.55983e-24	0.00361	1	0
MON2	23041	broad.mit.edu	37	12	62929426	62929426	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:62929426C>T	uc001sre.2	+	14	2228	c.1837C>T	c.(1837-1839)CTG>TTG	p.L613L	MON2_uc009zqj.2_Silent_p.L613L|MON2_uc010ssl.1_Silent_p.L541L|MON2_uc010ssm.1_Intron|MON2_uc010ssn.1_Silent_p.L613L|MON2_uc001srf.2_Silent_p.L376L	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	613					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CAAAGGTTCCCTGCCTCCCCA	0.408			NA											27	70					0	0	0.003954	0	0
IRAK3	11213	broad.mit.edu	37	12	66620547	66620547	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:66620547A>T	uc001sth.2	+	7	800	c.698A>T	c.(697-699)GAG>GTG	p.E233V	IRAK3_uc010ssy.1_Missense_Mutation_p.E172V	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	233	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		TATTTTACAGAGACTGAGAAG	0.348			NA											20	70					0	0	0.00278	0	0
PTPRR	5801	broad.mit.edu	37	12	71054802	71054802	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:71054802G>T	uc001swi.1	-	12	2100	c.1684C>A	c.(1684-1686)CAG>AAG	p.Q562K	PTPRR_uc001swf.1_RNA|PTPRR_uc001swg.1_RNA|PTPRR_uc001swh.1_Missense_Mutation_p.Q317K|PTPRR_uc009zrs.2_Missense_Mutation_p.Q411K|PTPRR_uc010stq.1_Missense_Mutation_p.Q450K|PTPRR_uc010str.1_3'UTR	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	562	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		AGGAGGGGCTGGGCACTGTCT	0.532			NA											8	21					1.12685e-05	1.31281e-05	0.004482	1	0
BBS10	79738	broad.mit.edu	37	12	76740022	76740022	+	Silent	SNP	C	C	G	rs150530553		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:76740022C>G	uc001syd.1	-	2	1827	c.1743G>C	c.(1741-1743)CCG>CCC	p.P581P		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	581					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2						TACCCATATTCGGTAACTTAC	0.373			NA							Bardet-Biedl_syndrome				19	53					0	0	0.007413	0	0
SYT1	6857	broad.mit.edu	37	12	79679716	79679716	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:79679716G>T	uc001sys.2	+	6	987	c.316G>T	c.(316-318)GAT>TAT	p.D106Y	SYT1_uc001syt.2_Missense_Mutation_p.D106Y|SYT1_uc001syu.2_Missense_Mutation_p.D106Y|SYT1_uc001syv.2_Missense_Mutation_p.D106Y	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	106	Cytoplasmic (Potential).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						TAACATGAAAGATGTAAAAGA	0.303			NA											15	24					8.60227e-14	1.26894e-13	0.004007	1	0
PLXNC1	10154	broad.mit.edu	37	12	94613897	94613897	+	Silent	SNP	C	C	A	rs146510015		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:94613897C>A	uc001tdc.2	+	6	1909	c.1660C>A	c.(1660-1662)CGG>AGG	p.R554R		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	554	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						TCAGCCCAACCGGACCTGCAC	0.458			NA											47	118					5.34276e-22	8.84987e-22	0.00361	1	0
ELK3	2004	broad.mit.edu	37	12	96653534	96653534	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:96653534C>T	uc001teo.1	+	4	1307	c.1028C>T	c.(1027-1029)CCG>CTG	p.P343L		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	343					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CTTCTGACTCCGAGTCCACTG	0.527			NA											8	147					0	0	0.004482	0	0
UBE3B	89910	broad.mit.edu	37	12	109936051	109936051	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:109936051T>C	uc001top.2	+	11	1436	c.833T>C	c.(832-834)TTA>TCA	p.L278S	UBE3B_uc001toq.2_Missense_Mutation_p.L278S|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.L278S	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	278					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CTCACTGTTTTAGAATCCCAT	0.413			NA											61	134					0	0	0.00361	0	0
NOS1	4842	broad.mit.edu	37	12	117715825	117715825	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:117715825C>T	uc001twm.1	-	9	2289	c.1603G>A	c.(1603-1605)GAC>AAC	p.D535N		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	535					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGCTCAGGGTCATTGCCGTTG	0.602	Esophageal Squamous(162;1748 2599 51982 52956)		NA											5	94					0	0	0.001984	0	0
RSRC2	65117	broad.mit.edu	37	12	122990163	122990164	+	Nonsense_Mutation	DNP	GA	GA	AG			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:122990163_122990164GA>AG	uc001ucr.2	-	10	1361_1362	c.1215_1216TC>CT	c.(1213-1218)GCTCAG>GCCTAG	p.Q406*	RSRC2_uc001uco.2_Nonsense_Mutation_p.Q175*|RSRC2_uc001ucp.2_Nonsense_Mutation_p.Q347*|RSRC2_uc001ucq.2_Nonsense_Mutation_p.Q174*|RSRC2_uc001ucs.2_Nonsense_Mutation_p.Q175*|RSRC2_uc001uct.2_Nonsense_Mutation_p.Q358*|RSRC2_uc001ucu.2_Nonsense_Mutation_p.Q407*	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	406										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		ATTTCATACTGAGCATCTAAAT	0.396			NA											43	99					0	0	0.004672	0	0
KNTC1	9735	broad.mit.edu	37	12	123041966	123041966	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:123041966G>T	uc001ucv.2	+	17	1471	c.1308G>T	c.(1306-1308)GAG>GAT	p.E436D	KNTC1_uc010taf.1_Missense_Mutation_p.E399D	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	436					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ATATATTGGAGAAACTGGCAT	0.383			NA											16	36					2.31682e-05	2.67291e-05	0.003163	1	0
MMP17	4326	broad.mit.edu	37	12	132335487	132335487	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:132335487C>T	uc001ujc.1	+	10	1579	c.1480C>T	c.(1480-1482)CGT>TGT	p.R494C	MMP17_uc001ujd.1_Missense_Mutation_p.R410C	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	494	Hemopexin-like 4.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CTACTTCTTCCGTGGCCAGGA	0.657			NA											11	33					0	0	0.001855	0	0
EP400NL	347918	broad.mit.edu	37	12	132610920	132610920	+	Splice_Site	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:132610920G>T	uc001ujx.1	+	7		c.1827_splice	c.e7-1							Homo sapiens cDNA FLJ33915 fis, clone CTONG2016658.												0						TCATATTTCAGTTGCAAAAGA	0.358			NA											6	7					0.00116845	0.00127839	0.001168	1	0
MTUS2	23281	broad.mit.edu	37	13	30066847	30066847	+	Silent	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr13:30066847G>C	uc001usl.3	+	10	3658	c.3600G>C	c.(3598-3600)CTG>CTC	p.L1200L	MTUS2_uc001usm.3_Silent_p.L169L|MTUS2_uc010aau.2_Silent_p.L79L	NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	1190	Potential.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AACTGCGGCTGTCATTGCAGG	0.308			NA											14	48					0	0	0.003163	0	0
ITM2B	9445	broad.mit.edu	37	13	48835306	48835306	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr13:48835306C>T	uc001vbz.3	+	6	970	c.747C>T	c.(745-747)TTC>TTT	p.F249F		NM_021999	NP_068839	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	249	Lumenal (Potential).				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)		GCAATTGTTTCGCAATTCGGC	0.274			NA											4	41					0	0	0.009096	0	0
NALCN	259232	broad.mit.edu	37	13	101997748	101997748	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr13:101997748G>T	uc001vox.1	-	7	857	c.668C>A	c.(667-669)GCT>GAT	p.A223D	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.A223D|NALCN_uc001vpa.2_Missense_Mutation_p.A223D	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	223	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GTCTGGAATAGCTAAACTATT	0.398			NA											18	53					2.35188e-11	3.25097e-11	0.006122	1	0
ITGBL1	9358	broad.mit.edu	37	13	102367988	102367988	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr13:102367988G>C	uc001vpb.2	+	11	1688	c.1469G>C	c.(1468-1470)GGC>GCC	p.G490A	ITGBL1_uc010agb.2_Missense_Mutation_p.G441A|ITGBL1_uc001vpc.3_Missense_Mutation_p.G349A	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	490	X.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATCTGGCTTGGCTCAGAATAT	0.383			NA											49	141					0	0	0.00361	0	0
COL4A2	1284	broad.mit.edu	37	13	111130348	111130348	+	Splice_Site	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr13:111130348A>G	uc001vqx.2	+	30	2715	c.2426_splice	c.e30-2	p.G809_splice		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein						angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TGATTCCTGCAGGAAGCCAAG	0.547			NA											13	64					0	0	0.001855	0	0
RASA3	22821	broad.mit.edu	37	13	114762162	114762162	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr13:114762162G>C	uc001vui.2	-	21	2117	c.1986C>G	c.(1984-1986)TGC>TGG	p.C662W	RASA3_uc010tkk.1_Missense_Mutation_p.C630W|RASA3_uc001vuj.2_Missense_Mutation_p.C279W	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	662	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TGGCCTCCACGCAGTTGTTGG	0.607			NA											25	93					0	0	0.003954	0	0
POTEG	404785	broad.mit.edu	37	14	19553769	19553769	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:19553769G>T	uc001vuz.1	+	1	405	c.353G>T	c.(352-354)GGC>GTC	p.G118V	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	118										ovary(1)	1						AGCAAAGTGGGCCCTTGGGGA	0.597			NA											65	652					3.29585e-21	5.38414e-21	0.00361	1	0
OR11H6	122748	broad.mit.edu	37	14	20692109	20692109	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:20692109C>A	uc010tlc.1	+	1	241	c.241C>A	c.(241-243)CTG>ATG	p.L81M		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	81	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		GTACATCCTTCTGGGAAACTT	0.463			NA											35	76					3.67414e-24	6.24288e-24	0.002445	1	0
C14orf93	60686	broad.mit.edu	37	14	23468201	23468201	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:23468201G>A	uc001wib.1	-	2	342	c.32C>T	c.(31-33)CCT>CTT	p.P11L	C14orf93_uc001wic.1_Intron|C14orf93_uc001wid.1_Missense_Mutation_p.P11L|C14orf93_uc001wig.2_Missense_Mutation_p.P11L|C14orf93_uc001wih.2_Missense_Mutation_p.P11L|C14orf93_uc001wie.2_Missense_Mutation_p.P11L|C14orf93_uc001wia.3_Missense_Mutation_p.P11L|C14orf93_uc001wif.2_Intron	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	11						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		GCCACTGGGAGGGGAGAAGAG	0.592			NA											28	105					0	0	0.002096	0	0
C14orf93	60686	broad.mit.edu	37	14	23468206	23468206	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:23468206G>A	uc001wib.1	-	2	337	c.27C>T	c.(25-27)TTC>TTT	p.F9F	C14orf93_uc001wic.1_Intron|C14orf93_uc001wid.1_Silent_p.F9F|C14orf93_uc001wig.2_Silent_p.F9F|C14orf93_uc001wih.2_Silent_p.F9F|C14orf93_uc001wie.2_Silent_p.F9F|C14orf93_uc001wia.3_Silent_p.F9F|C14orf93_uc001wif.2_Intron	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	9						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		TGGGAGGGGAGAAGAGAATGG	0.587			NA											29	109					0	0	0.002445	0	0
LRFN5	145581	broad.mit.edu	37	14	42356354	42356354	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:42356354C>A	uc001wvm.2	+	3	1724	c.526C>A	c.(526-528)CTT>ATT	p.L176I	LRFN5_uc010ana.2_Missense_Mutation_p.L176I	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	176	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CTTGCATACCCTTAGTTTGGA	0.408			NA								HNSCC(30;0.082)			8	39					0.00307968	0.0033265	0.00308	1	0
FSCB	84075	broad.mit.edu	37	14	44974151	44974151	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:44974151A>T	uc001wvn.2	-	1	2349	c.2040T>A	c.(2038-2040)GCT>GCA	p.A680A		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	680	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		ACTGAACTTCAGCAGGGGCCT	0.612			NA											15	36					0	0	0.003163	0	0
FSCB	84075	broad.mit.edu	37	14	44976031	44976031	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:44976031C>A	uc001wvn.2	-	1	469	c.160G>T	c.(160-162)GAG>TAG	p.E54*		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	54						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TGCTGAAGCTCAGAAGATACT	0.413			NA											47	173					9.58827e-17	1.50419e-16	0.00361	1	0
C14orf106	55320	broad.mit.edu	37	14	45711253	45711253	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:45711253C>A	uc001wwf.2	-	4	1586	c.1127G>T	c.(1126-1128)GGA>GTA	p.G376V	C14orf106_uc010anh.2_RNA	NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	376					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TTTTTTAAGTCCATTTGTAAC	0.318	Ovarian(187;620 2054 7273 12043 20532)		NA											23	69					4.16121e-05	4.73627e-05	0.00278	1	0
CDKL1	8814	broad.mit.edu	37	14	50801307	50801307	+	Silent	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:50801307A>G	uc001wxz.2	-	7	802	c.774T>C	c.(772-774)TCT>TCC	p.S258S	ATP5S_uc010ant.1_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	257	Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					GGGCAGGATAAGAGATGTTTG	0.378			NA											83	239					0	0	0.00361	0	0
RTN1	6252	broad.mit.edu	37	14	60072161	60072161	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:60072161C>A	uc001xen.1	-	5	2246	c.2037G>T	c.(2035-2037)CTG>CTT	p.L679L	RTN1_uc001xem.1_Silent_p.L259L|RTN1_uc001xek.1_Silent_p.L111L|RTN1_uc001xel.1_RNA|RTN1_uc010apl.1_Silent_p.L96L	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	679	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		CGTAGAACTGCAGGCAGTCCG	0.473			NA											29	77					7.01153e-11	9.62463e-11	0.007291	1	0
GPHN	10243	broad.mit.edu	37	14	67579829	67579829	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:67579829G>T	uc001xiy.2	+	15	2589	c.1468G>T	c.(1468-1470)GTC>TTC	p.V490F	GPHN_uc001xix.2_Missense_Mutation_p.V523F|GPHN_uc010tss.1_Missense_Mutation_p.V536F|GPHN_uc010tst.1_Missense_Mutation_p.V459F|GPHN_uc010tsu.1_Missense_Mutation_p.V413F	NM_001024218	NP_001019389	Q9NQX3	GEPH_HUMAN	gephyrin isoform 2	490	MPT adenylyltransferase.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			ovary(2)	2		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		AACTGTAGGTGTCACAGAGGT	0.468			NA	T	MLL	AL								8	76					1.26484e-09	1.67423e-09	0.00308	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72165754	72165754	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:72165754C>T	uc001xms.2	+	11	3779	c.3431C>T	c.(3430-3432)TCC>TTC	p.S1144F	SIPA1L1_uc001xmt.2_Missense_Mutation_p.S1144F|SIPA1L1_uc001xmu.2_Missense_Mutation_p.S1144F|SIPA1L1_uc001xmv.2_Missense_Mutation_p.S1144F|SIPA1L1_uc010ttm.1_Missense_Mutation_p.S619F	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1144					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TTAGCAAGATCCCAGTGTCGG	0.488			NA											44	129					0	0	0.00874	0	0
SERPINA9	327657	broad.mit.edu	37	14	94931156	94931156	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:94931156G>A	uc001ydf.2	-	4	1153	c.992C>T	c.(991-993)TCT>TTT	p.S331F	SERPINA9_uc001yde.2_Missense_Mutation_p.S231F|SERPINA9_uc010avc.2_Missense_Mutation_p.S182F|SERPINA9_uc001ydg.2_Missense_Mutation_p.S295F|SERPINA9_uc001ydh.1_Missense_Mutation_p.S331F|SERPINA9_uc001ydi.1_Missense_Mutation_p.S295F	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	313					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GTAGGAGGCAGAAATGGAAAA	0.463			NA											33	82					0	0	0.003271	0	0
SERPINA12	145264	broad.mit.edu	37	14	94962881	94962881	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:94962881C>T	uc001ydj.2	-	4	1530	c.734G>A	c.(733-735)GGC>GAC	p.G245D		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	245					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		TTGGTATATGCCACTACGGAA	0.438			NA											5	221					0	0	0.000602	0	0
C15orf2	23742	broad.mit.edu	37	15	24921921	24921921	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:24921921C>A	uc001ywo.2	+	1	1381	c.907C>A	c.(907-909)CCT>ACT	p.P303T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	303	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AAAGAGGATGCCTGATGAGAA	0.572			NA											25	77					1.64293e-13	2.40558e-13	0.00333	1	0
GABRA5	2558	broad.mit.edu	37	15	27185175	27185175	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:27185175G>T	uc001zbd.1	+	10	1167	c.828G>T	c.(826-828)CAG>CAT	p.Q276H	GABRB3_uc001zbb.2_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	276	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTTATCACAGGTGTCCTTTT	0.493			NA											10	44					4.68919e-08	5.97998e-08	0.008291	1	0
OCA2	4948	broad.mit.edu	37	15	28230275	28230275	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:28230275C>A	uc001zbh.3	-	13	1409	c.1299G>T	c.(1297-1299)GCG>GCT	p.A433A	OCA2_uc010ayv.2_Silent_p.A409A	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	433	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGAGGACGGCCGCGATGAGAC	0.602			NA							Oculocutaneous_Albinism				22	34					8.10497e-08	1.02261e-07	0.010504	1	0
C15orf55	256646	broad.mit.edu	37	15	34640257	34640257	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:34640257C>A	uc001zif.2	+	2	259	c.104C>A	c.(103-105)TCT>TAT	p.S35Y	C15orf55_uc010ucc.1_Missense_Mutation_p.S63Y|C15orf55_uc010ucd.1_Missense_Mutation_p.S53Y	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	35	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CCACCAACTTCTGACCCACCA	0.572			NA	T	BRD3|BRD4	lethal midline carcinoma								54	136					9.22156e-22	1.52323e-21	0.00361	1	0
GATM	2628	broad.mit.edu	37	15	45654417	45654417	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:45654417T>C	uc001zvc.2	-	9	1491	c.1162A>G	c.(1162-1164)ATC>GTC	p.I388V	GATM_uc001zvb.2_Missense_Mutation_p.I259V	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	388					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	ATGGTAGTGATACCTGCATTG	0.478			NA											8	19					0	0	0.00308	0	0
TCF12	6938	broad.mit.edu	37	15	57212142	57212142	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:57212142A>T	uc002aec.2	+	2	315	c.31A>T	c.(31-33)ATA>TTA	p.I11L	ZNF280D_uc002adw.1_5'Flank|TCF12_uc010ugm.1_Missense_Mutation_p.I63L|TCF12_uc010ugn.1_Missense_Mutation_p.I11L|TCF12_uc002aea.2_Missense_Mutation_p.I11L|TCF12_uc010bfs.2_5'UTR|TCF12_uc002aeb.2_Missense_Mutation_p.I11L|TCF12_uc002aed.2_Missense_Mutation_p.I11L|LOC145783_uc002adz.1_5'Flank	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	11					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CATGGCCGCTATAGGGACCGA	0.532			NA	T	TEC	extraskeletal myxoid chondrosarcoma								21	56					0	0	0.010504	0	0
AQP9	366	broad.mit.edu	37	15	58465266	58465266	+	Splice_Site	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:58465266G>T	uc002aez.2	+	3	596	c.239_splice	c.e3-1	p.G80_splice	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_Splice_Site_p.G15_splice	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9						cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		TTCCCTTGCAGGTGGTCACAT	0.463			NA											95	224					2.01602e-52	3.78323e-52	0.00361	1	0
HERC1	8925	broad.mit.edu	37	15	64067496	64067496	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:64067496T>A	uc002amp.2	-	2	475	c.327A>T	c.(325-327)GTA>GTT	p.V109V	HERC1_uc010uil.1_Silent_p.V109V|HERC1_uc010bgt.1_Silent_p.V109V|HERC1_uc002amq.1_Silent_p.V109V	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	109					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CACGCTGGAGTACAAGCAGTC	0.473			NA											33	75					0	0	0.002445	0	0
LRRC49	54839	broad.mit.edu	37	15	71305143	71305143	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:71305143G>C	uc002asw.2	+	14	1841	c.1594G>C	c.(1594-1596)GTG>CTG	p.V532L	LRRC49_uc002asu.2_Missense_Mutation_p.V522L|LRRC49_uc002asx.2_Missense_Mutation_p.V488L|LRRC49_uc010ukf.1_Missense_Mutation_p.V537L|LRRC49_uc002asy.2_Missense_Mutation_p.V238L|LRRC49_uc002asz.2_Missense_Mutation_p.V504L	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	532						cytoplasm|microtubule				ovary(1)	1						GTCTCTTCAGGTGACACAGAA	0.373			NA											10	26					0	0	0.008291	0	0
SEMA7A	8482	broad.mit.edu	37	15	74707191	74707191	+	Silent	SNP	C	C	T	rs147975982		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:74707191C>T	uc002axv.2	-	9	1123	c.1083G>A	c.(1081-1083)CCG>CCA	p.P361P	SEMA7A_uc010ulk.1_Silent_p.P196P|SEMA7A_uc010ull.1_Silent_p.P347P	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	361	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						TGCCAGGCCGCGGGTTGGGAA	0.627			NA											10	73					0	0	0.008291	0	0
C15orf26	161502	broad.mit.edu	37	15	81436103	81436103	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:81436103G>T	uc002bgb.2	+	5	605	c.578G>T	c.(577-579)TGG>TTG	p.W193L	C15orf26_uc010blp.1_Missense_Mutation_p.W168L	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	193											0						GTGAACTGCTGGCAGGCTGCC	0.537			NA											82	194					1.7488e-33	3.1236e-33	0.00361	1	0
NTRK3	4916	broad.mit.edu	37	15	88472600	88472600	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr15:88472600C>A	uc002bme.1	-	16	2117	c.1955G>T	c.(1954-1956)GGG>GTG	p.G652V	NTRK3_uc002bmh.2_Missense_Mutation_p.G644V|NTRK3_uc002bmf.1_Missense_Mutation_p.G652V|NTRK3_uc010upl.1_Missense_Mutation_p.G554V|NTRK3_uc010bnh.1_Missense_Mutation_p.G644V	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	652	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TTGGGAGAGCCCCAGCTCACC	0.612			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			15	38					0.00400662	0.00431987	0.004007	1	0
CACNA1H	8912	broad.mit.edu	37	16	1262039	1262039	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:1262039G>T	uc002cks.2	+	25	4908	c.4660G>T	c.(4660-4662)GTG>TTG	p.V1554L	CACNA1H_uc002ckt.2_Missense_Mutation_p.V1554L|CACNA1H_uc002cku.2_Missense_Mutation_p.V260L|CACNA1H_uc010brj.2_Missense_Mutation_p.V260L|CACNA1H_uc002ckv.2_Missense_Mutation_p.V260L	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1554	Helical; Name=S6 of repeat III; (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGTGGGCGTCGTGGTCGAGAA	0.632			NA											64	205					2.18329e-32	3.84181e-32	0.00361	1	0
BAIAP3	8938	broad.mit.edu	37	16	1396022	1396022	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:1396022G>T	uc002clk.1	+	24	2349	c.2349G>T	c.(2347-2349)CTG>CTT	p.L783L	BAIAP3_uc002clj.2_Silent_p.L765L|BAIAP3_uc010uuz.1_Silent_p.L748L|BAIAP3_uc010uva.1_Silent_p.L720L|BAIAP3_uc010uvc.1_Silent_p.L712L	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	783	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				ATACGGAGCTGCTTCGGAAGA	0.682			NA											7	33					0.000157383	0.000176091	0.00308	1	0
RPL3L	6123	broad.mit.edu	37	16	2002992	2002992	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:2002992G>T	uc002cnh.2	-	3	295	c.248C>A	c.(247-249)CCC>CAC	p.P83H		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	83					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						CACCACTAGGGGCGGCGTTTC	0.607			NA											18	71					0.00047179	0.000523916	0.00333	1	0
SRRM2	23524	broad.mit.edu	37	16	2818263	2818263	+	Splice_Site	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:2818263G>T	uc002crk.2	+	11	8282	c.7733_splice	c.e11+1	p.R2578_splice		NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300							Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CACTGAAGAGGTGAGGGAGCT	0.458			NA											31	59					6.00712e-18	9.57587e-18	0.002445	1	0
CPPED1	55313	broad.mit.edu	37	16	12758931	12758931	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:12758931C>A	uc002dca.3	-	4	868	c.757G>T	c.(757-759)GGG>TGG	p.G253W	CPPED1_uc002dcb.3_Missense_Mutation_p.G111W|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	253							hydrolase activity|metal ion binding				0						TAGGTACCCCCGGCATTCCTG	0.582			NA											40	38					6.2361e-21	1.01594e-20	0.007835	1	0
THUMPD1	55623	broad.mit.edu	37	16	20748250	20748250	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:20748250T>A	uc002dho.2	-	4	1152	c.1014A>T	c.(1012-1014)GCA>GCT	p.A338A	THUMPD1_uc010vaz.1_Silent_p.A191A|THUMPD1_uc002dhp.2_Silent_p.A338A	NM_017736	NP_060206	Q9NXG2	THUM1_HUMAN	THUMP domain containing 1	338											0						TGGCTTGACTTGCAAGTTCAG	0.393			NA											24	57					0	0	0.007291	0	0
Unknown	0	broad.mit.edu	37	16	21854852	21854852	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:21854852C>T	uc002djr.3	-	6	582	c.400G>A	c.(400-402)GGA>AGA	p.G134R	uc002djs.3_RNA|uc002djq.3_Missense_Mutation_p.G115R|uc010vbn.1_Missense_Mutation_p.G134R	NM_130464	NP_569731			nuclear pore complex interacting protein-like 3												NA						ATTTTATTTCCTCGAAAGGAA	0.423			NA											42	566					0	0	0.002852	0	0
EEF2K	29904	broad.mit.edu	37	16	22268069	22268069	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:22268069G>T	uc002dki.2	+	7	1104	c.619G>T	c.(619-621)GTG>TTG	p.V207L	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	207	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		ATCCCACCAGGTGGACATCAT	0.542	NSCLC(195;1411 2157 20319 27471 51856)		NA											9	47					3.86212e-05	4.4043e-05	0.008291	1	0
USP31	57478	broad.mit.edu	37	16	23093759	23093759	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:23093759C>A	uc002dll.2	-	12	1950	c.1950G>T	c.(1948-1950)CAG>CAT	p.Q650H	USP31_uc010bxm.2_Translation_Start_Site	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	650					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		ATTTCCATACCTGCCGAAATC	0.468			NA											24	111					4.59853e-10	6.12793e-10	0.005443	1	0
IL4R	3566	broad.mit.edu	37	16	27374034	27374034	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:27374034A>T	uc002don.2	+	11	1603	c.1361A>T	c.(1360-1362)AAG>ATG	p.K454M	IL4R_uc002dop.3_Missense_Mutation_p.K439M|IL4R_uc010bxy.2_Missense_Mutation_p.K454M|IL4R_uc002doo.2_Missense_Mutation_p.K294M	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	454	Cytoplasmic (Potential).|Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						GCAGGGCCCAAGGAGGCACCT	0.617			NA											50	92					0	0	0.00361	0	0
LONP2	83752	broad.mit.edu	37	16	48303941	48303941	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:48303941A>T	uc002efi.1	+	7	1086	c.997A>T	c.(997-999)AGG>TGG	p.R333W	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.R289W	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	333					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						CCTGGACATTAGGGCAGCCCG	0.383			NA											22	97					0	0	0.004656	0	0
CHD9	80205	broad.mit.edu	37	16	53358160	53358160	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:53358160C>G	uc002ehb.2	+	38	8211	c.8047C>G	c.(8047-8049)CAG>GAG	p.Q2683E	CHD9_uc002egy.2_Missense_Mutation_p.Q2667E|CHD9_uc002ehc.2_Missense_Mutation_p.Q2668E|CHD9_uc002ehf.2_Missense_Mutation_p.Q1781E|CHD9_uc010cbw.2_Missense_Mutation_p.Q749E	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2683					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ACAAAACTTGCAGTCACTGCA	0.488			NA											3	72					0	0	0.004672	0	0
ESRP2	80004	broad.mit.edu	37	16	68265245	68265245	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:68265245G>A	uc010cfa.1	-	12	1765	c.1577C>T	c.(1576-1578)ACA>ATA	p.T526I	ESRP2_uc002evp.1_RNA|ESRP2_uc002evq.1_Missense_Mutation_p.T516I	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	526	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						CTCTGCTGATGTCATCTGAAT	0.562			NA											33	37					0	0	0.002096	0	0
FTSJD1	55783	broad.mit.edu	37	16	71318653	71318653	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:71318653C>A	uc010cga.2	-	3	1577	c.1171G>T	c.(1171-1173)GAA>TAA	p.E391*	FTSJD1_uc002ezy.3_Nonsense_Mutation_p.E391*|FTSJD1_uc002ezz.3_Nonsense_Mutation_p.E391*	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	391						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						TTCAGCTTTTCTTGTTCCGCC	0.313			NA											5	13					0.000602214	0.000662548	0.000602	1	0
ZNF23	7571	broad.mit.edu	37	16	71482343	71482343	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:71482343C>A	uc002faf.2	-	6	2399	c.1585G>T	c.(1585-1587)GAG>TAG	p.E529*	ZNF23_uc002fad.2_Nonsense_Mutation_p.E471*|ZNF23_uc002fae.2_Nonsense_Mutation_p.E471*|ZNF23_uc010vmf.1_Nonsense_Mutation_p.E471*|ZNF23_uc002fag.2_Nonsense_Mutation_p.E471*|ZNF23_uc002fah.2_Nonsense_Mutation_p.E529*|ZNF23_uc002fai.2_Nonsense_Mutation_p.E568*	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	529					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		AAAGGTTTCTCCCCAGTATGT	0.418			NA											31	56					1.13719e-10	1.54668e-10	0.008361	1	0
CHST4	10164	broad.mit.edu	37	16	71571552	71571552	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:71571552C>A	uc002fan.2	+	2	1153	c.972C>A	c.(970-972)GCC>GCA	p.A324A	CHST4_uc002fao.2_Silent_p.A324A	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	324	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						ACACAAATGCCAGGGATGCCC	0.522			NA									OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	29					1.3612e-06	1.66776e-06	0.003163	1	0
MBTPS1	8720	broad.mit.edu	37	16	84103628	84103628	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:84103628C>G	uc002fhi.2	-	14	2300	c.1798G>C	c.(1798-1800)GAA>CAA	p.E600Q	MBTPS1_uc002fhh.2_Missense_Mutation_p.E104Q	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	600	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						GAAGTCTGTTCTGCACCATTT	0.393			NA											55	114					0	0	0.00361	0	0
WDR81	124997	broad.mit.edu	37	17	1640949	1640949	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:1640949A>T	uc002fti.2	+	10	2376	c.2115A>T	c.(2113-2115)TCA>TCT	p.S705S	WDR81_uc002fth.2_Silent_p.S881S|WDR81_uc010vqp.1_Silent_p.S729S|WDR81_uc002ftj.2_Silent_p.S1932S|WDR81_uc010vqq.1_Silent_p.S563S	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	705										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGCTGGGCTCAGACAACGGGG	0.652			NA											22	35					0	0	0.005443	0	0
MYH1	4619	broad.mit.edu	37	17	10397739	10397739	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:10397739T>A	uc002gmo.2	-	39	5693	c.5599A>T	c.(5599-5601)AGG>TGG	p.R1867W	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1867	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCCTGGAGCCTGAGAATATTC	0.393			NA											50	158					0	0	0.00361	0	0
MYO15A	51168	broad.mit.edu	37	17	18023924	18023924	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:18023924G>A	uc010vxh.1	+	2	2148	c.1810G>A	c.(1810-1812)GAG>AAG	p.E604K		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	604	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGCTGTCAGGGAGGCGGCCTA	0.697			NA											4	4					0	0	0.001168	0	0
GIT1	28964	broad.mit.edu	37	17	27910597	27910597	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:27910597C>A	uc002hef.2	-	2	304	c.90G>T	c.(88-90)GTG>GTT	p.V30V	GIT1_uc002heg.2_Silent_p.V30V|GIT1_uc010wbg.1_Silent_p.V30V|GIT1_uc010csb.1_Silent_p.V30V	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	30	Arf-GAP.|C4-type.				regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		ACTCGTCACACACCAGCACAC	0.572	Colon(81;41 1719 20078 35068)		NA											7	17					8.12818e-05	9.16352e-05	0.001984	1	0
CCT6B	10693	broad.mit.edu	37	17	33266313	33266313	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:33266313T>A	uc002hig.2	-	10	1196	c.1102A>T	c.(1102-1104)AAC>TAC	p.N368Y	CCT6B_uc010ctg.2_Missense_Mutation_p.N331Y|CCT6B_uc010wcc.1_Missense_Mutation_p.N323Y	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	368					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				GAGCAAGGGTTAACACACTCC	0.343			NA											35	99					0	0	0.003755	0	0
SLFN11	91607	broad.mit.edu	37	17	33687261	33687261	+	Splice_Site	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:33687261C>A	uc010ctp.2	-	5	1640	c.1198_splice	c.e5+1	p.V400_splice	SLFN11_uc010ctq.2_Splice_Site_p.V400_splice|SLFN11_uc002hjh.3_Splice_Site_p.V400_splice|SLFN11_uc002hjg.3_Splice_Site_p.V400_splice|SLFN11_uc010ctr.2_Splice_Site_p.V400_splice	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11							nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACCATAATTACCTGAAAATAA	0.393			NA											10	52					4.68919e-08	5.97998e-08	0.008291	1	0
LYZL6	57151	broad.mit.edu	37	17	34264778	34264778	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:34264778G>A	uc002hkj.1	-	2	432	c.282C>T	c.(280-282)TGC>TGT	p.C94C	LYZL6_uc002hkk.1_Silent_p.C94C	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	94					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTCTACGTGGCAAAGGTTTT	0.512			NA											4	109					0	0	0.009096	0	0
HDAC5	10014	broad.mit.edu	37	17	42168703	42168703	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:42168703T>A	uc002ifd.1	-	11	1533	c.1322A>T	c.(1321-1323)CAT>CTT	p.H441L	HDAC5_uc002ife.1_Missense_Mutation_p.H441L|HDAC5_uc002iff.1_Missense_Mutation_p.H442L|HDAC5_uc010czp.1_Missense_Mutation_p.H441L|HDAC5_uc002ifh.2_Missense_Mutation_p.H441L	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	441					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		CAGGGAGGCATGCCCGTGGGG	0.662			NA											6	23					0	0	0.00308	0	0
FMNL1	752	broad.mit.edu	37	17	43320574	43320574	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:43320574C>A	uc002iin.2	+	17	2300	c.2100C>A	c.(2098-2100)GCC>GCA	p.A700A	FMNL1_uc002iiq.2_Silent_p.A278A|FMNL1_uc010dag.2_RNA	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	700	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						GTAAGGCAGCCCAGAAGGCCC	0.597	GBM(164;1247 1997 8702 11086 51972)		NA											57	149					6.09941e-20	9.90944e-20	0.00361	1	0
SKAP1	8631	broad.mit.edu	37	17	46247980	46247980	+	Nonsense_Mutation	SNP	G	G	A	rs142272724		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:46247980G>A	uc002ini.1	-	10	980	c.868C>T	c.(868-870)CGA>TGA	p.R290*	SKAP1_uc002inj.1_Nonsense_Mutation_p.R290*|SKAP1_uc010dbd.1_Nonsense_Mutation_p.R196*|SKAP1_uc010dbe.1_Nonsense_Mutation_p.R290*	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	290	Interaction with FYB.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						CCTCCTTTTCGTCGAGTGCCA	0.408			NA											53	198					0	0	0.00361	0	0
CA10	56934	broad.mit.edu	37	17	49710885	49710885	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:49710885G>T	uc002itw.3	-	8	1902	c.916C>A	c.(916-918)CAG>AAG	p.Q306K	CA10_uc002itu.3_Missense_Mutation_p.Q235K|CA10_uc002itv.3_Missense_Mutation_p.Q312K|CA10_uc002itx.3_Missense_Mutation_p.Q306K|CA10_uc002ity.3_Missense_Mutation_p.Q306K|CA10_uc002itz.2_Missense_Mutation_p.Q306K	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	306					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TCCTTCCCCTGTAAACTGAAG	0.512			NA											28	76					1.08312e-15	1.65966e-15	0.009535	1	0
CA10	56934	broad.mit.edu	37	17	49731069	49731069	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:49731069A>T	uc002itw.3	-	5	1480	c.494T>A	c.(493-495)CTA>CAA	p.L165Q	CA10_uc002itu.3_Missense_Mutation_p.L94Q|CA10_uc002itv.3_Missense_Mutation_p.L171Q|CA10_uc002itx.3_Missense_Mutation_p.L165Q|CA10_uc002ity.3_Missense_Mutation_p.L165Q|CA10_uc002itz.2_Missense_Mutation_p.L165Q	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	165					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			ATTCGTATATAGCTCATGGTT	0.408			NA											29	80					0	0	0.008361	0	0
AKAP1	8165	broad.mit.edu	37	17	55193622	55193622	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:55193622G>C	uc002iux.2	+	7	2663	c.2432G>C	c.(2431-2433)AGG>ACG	p.R811T	AKAP1_uc010wnl.1_Missense_Mutation_p.R811T|AKAP1_uc010dcm.2_Missense_Mutation_p.R811T	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	811	Tudor.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					CGGCAAATCAGGTGAGCGGAG	0.572			NA											26	101					0	0	0.004656	0	0
MKS1	54903	broad.mit.edu	37	17	56294052	56294052	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:56294052C>A	uc002ivr.1	-	3	311	c.236G>T	c.(235-237)GGG>GTG	p.G79V	MKS1_uc010wnq.1_5'UTR|MKS1_uc002ivs.1_Missense_Mutation_p.G79V	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	79					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						CTCCTGCCACCCAATCACAAT	0.453			NA											7	41					0.000274275	0.00030515	0.004482	1	0
CLTC	1213	broad.mit.edu	37	17	57743971	57743971	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:57743971G>T	uc002ixq.1	+	12	2356	c.1913G>T	c.(1912-1914)CGT>CTT	p.R638L	CLTC_uc002ixp.2_Missense_Mutation_p.R638L|CLTC_uc002ixr.1_Missense_Mutation_p.R642L	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	638	Heavy chain arm.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GATATAAAACGTGCAGTGGTT	0.388			NA	T	ALK|TFE3	ALCL|renal 								3	47					6.4e-05	7.2705e-05	0.004672	1	0
SDK2	54549	broad.mit.edu	37	17	71397871	71397871	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:71397871G>A	uc010dfm.2	-	20	2701	c.2701C>T	c.(2701-2703)CTG>TTG	p.L901L	SDK2_uc002jjt.3_Silent_p.L60L|SDK2_uc010dfn.2_Silent_p.L580L	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	901	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						CTGAAGCTCAGGTGTCCCACG	0.577			NA											5	5					0	0	0.000602	0	0
UNK	85451	broad.mit.edu	37	17	73780812	73780812	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:73780812G>A	uc002jpm.2	+	2	79	c.79G>A	c.(79-81)GAC>AAC	p.D27N	UNK_uc002jpn.2_RNA|UNK_uc002jpo.2_RNA	NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	Error:Variant_position_missing_in_Q9C0B0_after_alignment							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATTCCAGCCGGACATAGAACC	0.647			NA											5	41					0	0	0.001984	0	0
UNK	85451	broad.mit.edu	37	17	73780814	73780814	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:73780814C>A	uc002jpm.2	+	2	81	c.81C>A	c.(79-81)GAC>GAA	p.D27E	UNK_uc002jpn.2_RNA|UNK_uc002jpo.2_RNA	NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	Error:Variant_position_missing_in_Q9C0B0_after_alignment							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCAGCCGGACATAGAACCAC	0.642			NA											5	41					3.59834e-05	4.1273e-05	0.001168	1	0
UBE2O	63893	broad.mit.edu	37	17	74395027	74395027	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:74395027C>T	uc002jrm.3	-	10	1739	c.1674G>A	c.(1672-1674)ATG>ATA	p.M558I	UBE2O_uc002jrn.3_Missense_Mutation_p.M558I|UBE2O_uc002jrl.3_Missense_Mutation_p.M161I	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	558							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						CATCCTGCCACATCACGTCGG	0.622			NA											11	57					0	0	0.002445	0	0
SMCHD1	23347	broad.mit.edu	37	18	2698038	2698038	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:2698038A>T	uc002klm.3	+	10	1530	c.1341A>T	c.(1339-1341)TCA>TCT	p.S447S	SMCHD1_uc002klk.3_5'Flank	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	447					chromosome organization		ATP binding				0						GCTTTCCATCAAGTATGTTAA	0.333			NA											3	8					0	0	0.004672	0	0
LAMA1	284217	broad.mit.edu	37	18	7015801	7015801	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:7015801A>T	uc002knm.2	-	22	3140	c.3046T>A	c.(3046-3048)TGC>AGC	p.C1016S	LAMA1_uc010wzj.1_Missense_Mutation_p.C492S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1016	Laminin EGF-like 11.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAGGGGGGCAGACACACTCT	0.552			NA											36	126					0	0	0.005524	0	0
FAM59A	64762	broad.mit.edu	37	18	29867330	29867330	+	Silent	SNP	C	C	A	rs146498252		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:29867330C>A	uc002kxl.2	-	4	1286	c.1230G>T	c.(1228-1230)GGG>GGT	p.G410G	FAM59A_uc002kxk.1_Silent_p.G410G	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	410										ovary(1)|skin(1)	2						CCCAATCTCCCCCCAGGTCCC	0.537			NA											27	102					7.92952e-12	1.10901e-11	0.003954	1	0
SLC14A2	8170	broad.mit.edu	37	18	43217060	43217060	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:43217060C>T	uc010dnj.2	+	7	1077	c.756C>T	c.(754-756)GGC>GGT	p.G252G	SLC14A2_uc002lbb.2_Silent_p.G252G|SLC14A2_uc002lbe.2_Silent_p.G252G	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	252	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CAGCCACAGGCCACTACAACC	0.512			NA											81	111					0	0	0.00361	0	0
DCC	1630	broad.mit.edu	37	18	50923679	50923679	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:50923679C>A	uc002lfe.1	+	18	3277	c.2690C>A	c.(2689-2691)TCA>TAA	p.S897*	DCC_uc010xdr.1_Nonsense_Mutation_p.S725*|DCC_uc010dpf.1_Nonsense_Mutation_p.S532*	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	897	Extracellular (Potential).|Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTTGTATAGTCAGAAGACACA	0.328			NA											10	28					1.58986e-06	1.92799e-06	0.008291	1	0
CDH7	1005	broad.mit.edu	37	18	63547735	63547735	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:63547735G>T	uc002ljz.2	+	12	2288	c.1963G>T	c.(1963-1965)GAC>TAC	p.D655Y	CDH7_uc002lkb.2_Missense_Mutation_p.D655Y	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	655	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GAGATACGATGACGAGGGCGG	0.493			NA											20	58					7.45023e-12	1.04444e-11	0.010504	1	0
ZNF516	9658	broad.mit.edu	37	18	74154334	74154334	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:74154334G>A	uc010dqx.1	-	2	912	c.677C>T	c.(676-678)GCG>GTG	p.A226V	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGGCCCCTGCGCGGTGATGTG	0.697			NA											11	31					0	0	0.001368	0	0
GALR1	2587	broad.mit.edu	37	18	74963084	74963085	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr18:74963084_74963085CC>AA	uc002lms.3	+	1	1077_1078	c.580_581CC>AA	c.(580-582)CCT>AAT	p.P194N		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	194	Extracellular (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		GTGGCCCGACCCTCGCCACAAG	0.663			NA											27	115					0	0	0.004672	0	0
LPPR3	79948	broad.mit.edu	37	19	814479	814479	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:814479G>T	uc002lpx.1	-	7	850	c.786C>A	c.(784-786)GAC>GAA	p.D262E	LPPR3_uc010dru.1_Missense_Mutation_p.D174E|LPPR3_uc002lpw.1_Missense_Mutation_p.D290E|LPPR3_uc002lpy.1_Missense_Mutation_p.D43E	NM_024888	NP_079164	Q6T4P5	LPPR3_HUMAN	plasticity-related protein 2	262						integral to membrane	phosphatidate phosphatase activity				0						CGGCATACACGTCCACAGGGT	0.657			NA											10	28					1.08611e-07	1.36454e-07	0.000978	1	0
MIDN	90007	broad.mit.edu	37	19	1254919	1254919	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:1254919A>T	uc002lrp.2	+	6	1230	c.715A>T	c.(715-717)ACG>TCG	p.T239S		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	239						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTCCCCCACGGCCAGCAG	0.667			NA											46	135					0	0	0.00361	0	0
MUC16	94025	broad.mit.edu	37	19	9012894	9012894	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:9012894A>T	uc002mkp.2	-	34	38754	c.38550T>A	c.(38548-38550)GCT>GCA	p.A12850A	MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12852	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAGAGGGCCAGCAGCTGTAG	0.463			NA											9	268					0	0	0.006214	0	0
MUC16	94025	broad.mit.edu	37	19	9063110	9063110	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:9063110C>G	uc002mkp.2	-	3	24540	c.24336G>C	c.(24334-24336)CAG>CAC	p.Q8112H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8114	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGGTTCTGTCTGAATTCTGC	0.498			NA											4	172					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9065905	9065905	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:9065905T>A	uc002mkp.2	-	3	21745	c.21541A>T	c.(21541-21543)ACA>TCA	p.T7181S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7183	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACGCTGCTGTGTTTGTGGAA	0.493			NA											49	167					0	0	0.00361	0	0
MUC16	94025	broad.mit.edu	37	19	9071876	9071876	+	Silent	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:9071876A>G	uc002mkp.2	-	3	15774	c.15570T>C	c.(15568-15570)CCT>CCC	p.P5190P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5192	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCTCAGTCTAGGAGTCAAGA	0.483			NA											129	328					0	0	0.00361	0	0
CYP4F11	57834	broad.mit.edu	37	19	16025585	16025585	+	Silent	SNP	G	G	T	rs140718122		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:16025585G>T	uc002nbu.2	-	10	1272	c.1236C>A	c.(1234-1236)CGC>CGA	p.R412R	CYP4F11_uc010eab.1_Silent_p.R412R|CYP4F11_uc002nbt.2_Silent_p.R412R	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	412					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						TGGGGATGACGCGGCCGTCTG	0.632			NA											33	94					2.42023e-17	3.81701e-17	0.003271	1	0
UPF1	5976	broad.mit.edu	37	19	18968170	18968170	+	Silent	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:18968170G>C	uc002nkg.2	+	15	2318	c.2043G>C	c.(2041-2043)GTG>GTC	p.V681V	UPF1_uc002nkf.2_Silent_p.V670V|UPF1_uc002nkh.2_5'Flank	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	681					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCCCAGTGGTGATGTGCAAGA	0.627			NA											26	107					0	0	0.00632	0	0
NDUFA13	51079	broad.mit.edu	37	19	19638158	19638159	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:19638158_19638159GG>TT	uc010xqy.1	+	3	750_751	c.491_492GG>TT	c.(490-492)CGG>CTT	p.R164L	NDUFA13_uc002nms.2_Missense_Mutation_p.R164L|NDUFA13_uc010xqx.1_Missense_Mutation_p.R164L|YJEFN3_uc002nmt.1_5'Flank|YJEFN3_uc010ecf.1_5'Flank|YJEFN3_uc002nmu.1_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	81					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	GAAACCGACCGGAGGTAGCACC	0.634			NA											9	59					0	0	0.004672	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567			NA											4	54					0	0	0.009096	0	0
C19orf40	91442	broad.mit.edu	37	19	33464469	33464469	+	Splice_Site	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:33464469G>A	uc002nud.3	+	3	361	c.243_splice	c.e3+1	p.N81_splice	CCDC123_uc002nty.2_5'Flank|CCDC123_uc010edg.2_5'Flank|CCDC123_uc002ntz.1_5'Flank|CCDC123_uc002nua.2_5'Flank|CCDC123_uc002nuc.1_5'Flank	NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa						DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					GGTTAGAAATGTAAGTATTAg	0.224			NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks					5	224					0	0	0.000602	0	0
GPATCH1	55094	broad.mit.edu	37	19	33588796	33588796	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:33588796A>G	uc002nug.1	+	8	1302	c.988A>G	c.(988-990)AAA>GAA	p.K330E		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	330						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					CAGGCAGTATAAAAACCAGAA	0.507	Pancreas(67;88 1713 4567 18227)		NA											34	126					0	0	0.00874	0	0
LRFN3	79414	broad.mit.edu	37	19	36430769	36430769	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:36430769G>T	uc002oco.2	+	2	894	c.442G>T	c.(442-444)GCC>TCC	p.A148S		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	148	LRR 4.|Extracellular (Potential).				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGCGCTGGCGGCCGGCGCCCT	0.677			NA											12	30					1.52009e-12	2.16686e-12	0.003163	1	0
RYR1	6261	broad.mit.edu	37	19	38939385	38939385	+	Missense_Mutation	SNP	T	T	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:38939385T>G	uc002oit.2	+	11	1184	c.1054T>G	c.(1054-1056)TCA>GCA	p.S352A	RYR1_uc002oiu.2_Missense_Mutation_p.S352A	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	352	Cytoplasmic.|MIR 5.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCATGTGGCCTCAGGACTGTG	0.547			NA											28	84					0	0	0.008361	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541382	40541382	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:40541382G>C	uc002omu.2	-	5	1449	c.1384C>G	c.(1384-1386)CAA>GAA	p.Q462E	ZNF780B_uc002omv.2_Missense_Mutation_p.Q314E	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	462	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGGCAATGTTGAATAAGTTGG	0.378			NA											17	107					0	0	0.00499	0	0
CCDC8	83987	broad.mit.edu	37	19	46914764	46914764	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:46914764C>G	uc002pep.2	-	1	2156	c.1304G>C	c.(1303-1305)GGC>GCC	p.G435A		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	435						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		TGCCCTCTGGCCAGCCCGGGC	0.597			NA											37	83					0	0	0.004878	0	0
GRLF1	2909	broad.mit.edu	37	19	47491246	47491246	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:47491246G>T	uc010ekv.2	+	3	3827	c.3827G>T	c.(3826-3828)GGA>GTA	p.G1276V		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1276	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		TTCTCCTCAGGACTGAGCACG	0.552			NA											12	29					0.00010058	0.000112962	0.001368	1	0
ELSPBP1	64100	broad.mit.edu	37	19	48519237	48519237	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:48519237G>T	uc002pht.2	+	4	451	c.296G>T	c.(295-297)TGG>TTG	p.W99L		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor	99	Fibronectin type-II 2.				single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		GGCAGTCTGTGGTGCTCAGTC	0.507			NA											31	91					1.62565e-12	2.30624e-12	0.002445	1	0
ZNF114	163071	broad.mit.edu	37	19	48790040	48790040	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:48790040C>T	uc002pil.1	+	6	1656	c.1159C>T	c.(1159-1161)CCC>TCC	p.P387S	ZNF114_uc010elv.1_Missense_Mutation_p.P387S|ZNF114_uc002pim.1_Missense_Mutation_p.P387S|ZNF114_uc002pin.2_Missense_Mutation_p.P353S	NM_153608	NP_705836	Q8NC26	ZN114_HUMAN	zinc finger protein 114	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		TGGAGAGAAACCCTATAAATG	0.408			NA											49	166					0	0	0.00361	0	0
CA11	770	broad.mit.edu	37	19	49142169	49142169	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:49142169G>T	uc002pjz.1	-	8	1499	c.937C>A	c.(937-939)CGA>AGA	p.R313R	SEC1_uc010xzv.1_Intron|SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron|DBP_uc002pjx.3_5'Flank|DBP_uc002pjy.2_5'Flank|DBP_uc010elz.1_5'Flank	NM_001217	NP_001208	O75493	CAH11_HUMAN	carbonic anhydrase XI precursor	313						extracellular region					0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		TTGGGGCCTCGGCAGCGCCTC	0.637			NA											8	18					0.000157383	0.000176091	0.00308	1	0
FUT1	2523	broad.mit.edu	37	19	49253722	49253722	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:49253722C>A	uc002pkk.2	-	4	1792	c.817G>T	c.(817-819)GAC>TAC	p.D273Y		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	273	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		TGGGAGGTGTCGATGTTTTCT	0.587			NA											54	126					4.25531e-23	7.14845e-23	0.00361	1	0
SHANK1	50944	broad.mit.edu	37	19	51169662	51169662	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:51169662G>T	uc002psx.1	-	22	5574	c.5555C>A	c.(5554-5556)CCC>CAC	p.P1852H	SHANK1_uc002psw.1_Missense_Mutation_p.P1236H	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1852	Poly-Pro.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CAAGGGCCCGGGCAGAGGTGG	0.677			NA											12	40					3.07112e-06	3.64235e-06	0.000978	1	0
C19orf75	284369	broad.mit.edu	37	19	51768891	51768891	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:51768891C>A	uc002pwb.1	+	3	673	c.292C>A	c.(292-294)CTA>ATA	p.L98I	C19orf75_uc010eov.1_Intron|C19orf75_uc010ycw.1_Intron	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	98						integral to membrane				ovary(1)|pancreas(1)	2						TTTGAGCATCCTACTGATGTC	0.537			NA											31	141					5.60225e-13	8.10277e-13	0.009535	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51918110	51918110	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:51918110C>A	uc002pwo.2	-	8	2199	c.1583G>T	c.(1582-1584)GGG>GTG	p.G528V	SIGLEC10_uc002pwp.2_Missense_Mutation_p.G470V|SIGLEC10_uc002pwq.2_Intron|SIGLEC10_uc002pwr.2_Intron|SIGLEC10_uc010ycy.1_Intron|SIGLEC10_uc010ycz.1_Intron|SIGLEC10_uc010eow.2_Intron|SIGLEC10_uc002pws.1_Intron	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	528	Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		ACTCTGGGCCCCATGGACGTT	0.662			NA											47	174					1.86633e-21	3.06575e-21	0.00361	1	0
FPR2	2358	broad.mit.edu	37	19	52272906	52272906	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:52272906C>A	uc002pxr.2	+	2	1040	c.995C>A	c.(994-996)ACT>AAT	p.T332N	FPR2_uc002pxs.3_Missense_Mutation_p.T332N|FPR2_uc010epf.2_Missense_Mutation_p.T332N	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	332	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.T332I(1)		lung(3)|ovary(1)	4						TCAGCCCCAACTAATGACACG	0.537			NA											16	40					1.01871e-10	1.39193e-10	0.008871	1	0
ZNF28	7576	broad.mit.edu	37	19	53311270	53311270	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:53311270C>A	uc002qad.2	-	3	252	c.132G>T	c.(130-132)CTG>CTT	p.L44L	ZNF28_uc002qac.2_5'UTR|ZNF28_uc010eqe.2_Intron	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		CCAGGGAGACCAGGTTCCTAT	0.493			NA											47	156					1.00221e-16	1.56811e-16	0.00361	1	0
NLRP12	91662	broad.mit.edu	37	19	54304481	54304481	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:54304481C>A	uc002qch.3	-	7	2976	c.2756G>T	c.(2755-2757)CGG>CTG	p.R919L	NLRP12_uc010eqw.2_Missense_Mutation_p.R202L|NLRP12_uc002qci.3_Missense_Mutation_p.R919L|NLRP12_uc002qcj.3_Missense_Mutation_p.R920L|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	919	LRR 4.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CGGGACTCACCGCAGGGTCTG	0.617			NA											22	50					3.5997e-14	5.34993e-14	0.002299	1	0
CACNG7	59284	broad.mit.edu	37	19	54445373	54445373	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:54445373C>T	uc002qcr.1	+	5	669	c.654C>T	c.(652-654)CGC>CGT	p.R218R		NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	218				GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST SPC -> VTSVGPRL (in Ref. 1; AAK20030).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCTTCTACCGCCCGCGTCTCA	0.687			NA											29	45					0	0	0.00632	0	0
LILRA1	11024	broad.mit.edu	37	19	55107393	55107393	+	Silent	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:55107393G>C	uc002qgh.1	+	6	1133	c.951G>C	c.(949-951)CTG>CTC	p.L317L	LILRA2_uc010yfg.1_Silent_p.L315L|LILRA1_uc010yfh.1_Silent_p.L317L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	317	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TGGACATCCTGATCGCAGGTG	0.682			NA											20	68					0	0	0.00333	0	0
PTPRH	5794	broad.mit.edu	37	19	55693445	55693445	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:55693445A>T	uc002qjq.2	-	19	3210	c.3137T>A	c.(3136-3138)CTT>CAT	p.L1046H	PTPRH_uc010esv.2_Missense_Mutation_p.L868H|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1046	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GAAGGGCCCAAGGAGACCCTC	0.607			NA											63	181					0	0	0.00361	0	0
NLRP8	126205	broad.mit.edu	37	19	56459349	56459349	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:56459349G>T	uc002qmh.2	+	1	152	c.81G>T	c.(79-81)TGG>TGT	p.W27C	NLRP8_uc010etg.2_Missense_Mutation_p.W27C	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	27						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTCCGCCCTGGACATTCTCTT	0.512			NA											24	129					3.08376e-08	3.96675e-08	0.00333	1	0
ZNF835	90485	broad.mit.edu	37	19	57175089	57175089	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:57175089T>C	uc010ygo.1	-	2	1544	c.1544A>G	c.(1543-1545)CAG>CGG	p.Q515R	ZNF835_uc010ygn.1_Missense_Mutation_p.Q493R	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						ATGCGTCCTCTGGTGTCGGAT	0.627			NA											63	246					0	0	0.00361	0	0
ZNF835	90485	broad.mit.edu	37	19	57175250	57175250	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:57175250C>T	uc010ygo.1	-	2	1383	c.1383G>A	c.(1381-1383)ACG>ACA	p.T461T	ZNF835_uc010ygn.1_Silent_p.T439T	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CGCCCGTGTGCGTGCGCTGGT	0.662			NA											17	92					0	0	0.004007	0	0
USP29	57663	broad.mit.edu	37	19	57641790	57641790	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:57641790C>A	uc002qny.2	+	4	2103	c.1747C>A	c.(1747-1749)CTG>ATG	p.L583M		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	583					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCAATGAAGCTGACCTCAGA	0.483			NA											41	91					2.45108e-15	3.74611e-15	0.00874	1	0
ZNF264	9422	broad.mit.edu	37	19	57705360	57705360	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:57705360G>A	uc002qob.2	+	2	564	c.151G>A	c.(151-153)GTG>ATG	p.V51M		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		TGGGCTCCTGGTGTCTCTGGG	0.587			NA											28	99					0	0	0.00632	0	0
ZNF135	7694	broad.mit.edu	37	19	58579298	58579298	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:58579298C>A	uc010yhq.1	+	5	1578	c.1482C>A	c.(1480-1482)ACC>ACA	p.T494T	ZNF135_uc002qre.2_Silent_p.T482T|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Silent_p.T440T|ZNF135_uc002qrg.2_Silent_p.T452T|ZNF135_uc010yhr.1_Silent_p.T303T	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	494					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CACACCTCACCCAACACCAGC	0.567			NA											25	65					1.26454e-06	1.55253e-06	0.005443	1	0
TTC15	51112	broad.mit.edu	37	2	3447625	3447625	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:3447625T>C	uc002qxm.1	+	6	1699	c.1493T>C	c.(1492-1494)CTG>CCG	p.L498P	TTC15_uc002qxn.1_Missense_Mutation_p.L498P|TTC15_uc010ewm.1_Missense_Mutation_p.L498P	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	498							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CAGGAGTCGCTGGATAGACTG	0.592			NA											12	32					0	0	0.001368	0	0
APOB	338	broad.mit.edu	37	2	21228213	21228213	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:21228213C>A	uc002red.2	-	26	11655	c.11527G>T	c.(11527-11529)GTA>TTA	p.V3843L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3843					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGTTGGCTACTGCATTTAGA	0.453			NA											4	156					0.00909568	0.00973599	0.009096	1	0
KRTCAP3	200634	broad.mit.edu	37	2	27666044	27666044	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:27666044G>T	uc002rks.2	+	4	394	c.377G>T	c.(376-378)CGC>CTC	p.R126L	KRTCAP3_uc010ylr.1_Missense_Mutation_p.R126L|KRTCAP3_uc002rkt.2_Missense_Mutation_p.R108L	NM_173853	NP_776252	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	126						integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					AACGGTGGCCGCCGCCTTATT	0.607			NA											85	161					1.09326e-46	2.0323e-46	0.00361	1	0
ALK	238	broad.mit.edu	37	2	29551229	29551229	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:29551229C>A	uc002rmy.2	-	6	2308	c.1401G>T	c.(1399-1401)GAG>GAT	p.E467D		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	467	LDL-receptor class A.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ACATCTGGCTCTCATCTTCTC	0.597			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				27	71					6.38683e-12	8.97486e-12	0.008361	1	0
VIT	5212	broad.mit.edu	37	2	37000953	37000953	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:37000953C>T	uc002rpl.2	+	8	920	c.699C>T	c.(697-699)ACC>ACT	p.T233T	VIT_uc010ynf.1_Silent_p.T162T|VIT_uc002rpm.2_Silent_p.T226T|VIT_uc010ezv.2_Silent_p.T226T|VIT_uc010ezw.2_Silent_p.T226T	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	233						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CCACTGCCACCTACACAAGCA	0.363			NA											9	30					0	0	0.008291	0	0
EPCAM	4072	broad.mit.edu	37	2	47607038	47607038	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:47607038G>T	uc002rvx.2	+	7	1146	c.788G>T	c.(787-789)GGT>GTT	p.G263V	EPCAM_uc002rvw.2_Missense_Mutation_p.G291V	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	263	Extracellular (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						TCAATGCAGGGTCTAAAAgct	0.254			NA							Lynch_syndrome				21	64					6.33239e-15	9.57935e-15	0.010504	1	0
ERLEC1	27248	broad.mit.edu	37	2	54045035	54045035	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:54045035G>A	uc002rxl.2	+	14	1661	c.1381G>A	c.(1381-1383)GTT>ATT	p.V461I	ASB3_uc002rxi.3_Intron|ERLEC1_uc002rxm.2_Missense_Mutation_p.V435I|ERLEC1_uc002rxn.2_Missense_Mutation_p.V407I	NM_015701	NP_056516	Q96DZ1	ERLEC_HUMAN	erlectin isoform 1	461					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			ovary(2)	2						TCTTCTTTAGGTTGAATCTCC	0.338			NA											9	48					0	0	0.004482	0	0
BMP10	27302	broad.mit.edu	37	2	69098254	69098254	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:69098254C>A	uc002sez.1	-	1	396	c.237G>T	c.(235-237)GTG>GTT	p.V79V		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	79					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						CTGGTGGGTCCACCTTGGCTG	0.468			NA											39	124					3.62531e-18	5.79463e-18	0.004289	1	0
TEX261	113419	broad.mit.edu	37	2	71216145	71216145	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:71216145G>A	uc002shn.2	-	5	489	c.375C>T	c.(373-375)GTC>GTT	p.V125V	TEX261_uc010fdy.2_Silent_p.V78V	NM_144582	NP_653183	Q6UWH6	TX261_HUMAN	testis expressed sequence 261	125	Helical; (Potential).					integral to membrane					0						AATAGGCCAGGACCTGGCAAC	0.577			NA											5	32					0	0	0.000602	0	0
NMS	129521	broad.mit.edu	37	2	101093867	101093867	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:101093867T>A	uc002tan.1	+	5	259	c.252T>A	c.(250-252)GTT>GTA	p.V84V		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	84					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						CACATCCAGTTAAAACTGGGG	0.368			NA											13	32					0	0	0.001855	0	0
IL1RL1	9173	broad.mit.edu	37	2	102964544	102964544	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:102964544T>A	uc002tbu.1	+	9	1381	c.1110T>A	c.(1108-1110)ACT>ACA	p.T370T	IL18R1_uc002tbw.3_Intron	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	370	Cytoplasmic (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CTTACAAGACTAGGAATGGTA	0.383			NA											19	61					0	0	0.001882	0	0
LRP1B	53353	broad.mit.edu	37	2	141665515	141665515	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:141665515G>T	uc002tvj.1	-	22	4423	c.3451C>A	c.(3451-3453)CTG>ATG	p.L1151M	LRP1B_uc010fnl.1_Missense_Mutation_p.L333M	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1151	Extracellular (Potential).|LDL-receptor class A 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTGGCTGCAGGCAGACTGAG	0.453	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			25	66					1.66031e-10	2.24274e-10	0.003954	1	0
PABPC1P2	728773	broad.mit.edu	37	2	147345742	147345742	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:147345742G>T	uc002twf.3	+	1	1118	c.202G>T	c.(202-204)GCT>TCT	p.A68S		NR_026904				RecName: Full=Putative protein PABPC1-like; AltName: Full=Polyadenylate-binding protein pseudogene 2;												0						TCCACAGACAGCTATGGATGT	0.388			NA											12	34					4.36969e-10	5.84927e-10	0.001855	1	0
UPP2	151531	broad.mit.edu	37	2	158980311	158980311	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:158980311T>A	uc002tzp.2	+	6	909	c.715T>A	c.(715-717)TTA>ATA	p.L239I	UPP2_uc002tzo.2_Missense_Mutation_p.L296I	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	239					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						AGAAAAAAAGTTAGACTACTT	0.453			NA											40	82					0	0	0.005524	0	0
TTN	7273	broad.mit.edu	37	2	179398197	179398197	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:179398197A>G	uc010zfg.1	-	307	95665	c.95441T>C	c.(95440-95442)TTT>TCT	p.F31814S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.F25509S|TTN_uc010zfi.1_Missense_Mutation_p.F25442S|TTN_uc010zfj.1_Missense_Mutation_p.F25317S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32741							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGATCTCAAAGCAGACACT	0.473			NA											19	35					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179629388	179629388	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:179629388C>A	uc010zfg.1	-	42	10078	c.9854G>T	c.(9853-9855)TGC>TTC	p.C3285F	TTN_uc010zfh.1_Missense_Mutation_p.C3239F|TTN_uc010zfi.1_Missense_Mutation_p.C3239F|TTN_uc010zfj.1_Missense_Mutation_p.C3239F|TTN_uc002umz.1_5'Flank|TTN_uc002unb.2_Missense_Mutation_p.C3285F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3285							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGAAATTTGCACTTGAAGCC	0.493			NA											62	103					2.89935e-36	5.24182e-36	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179642042	179642042	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:179642042C>A	uc010zfg.1	-	27	4872	c.4648G>T	c.(4648-4650)GTG>TTG	p.V1550L	TTN_uc010zfh.1_Missense_Mutation_p.V1504L|TTN_uc010zfi.1_Missense_Mutation_p.V1504L|TTN_uc010zfj.1_Missense_Mutation_p.V1504L|TTN_uc002unb.2_Missense_Mutation_p.V1550L|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1550							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATGTTCCACAGCTGAAAGA	0.348			NA											21	37					1.55795e-14	2.32711e-14	0.001882	1	0
COL3A1	1281	broad.mit.edu	37	2	189875383	189875383	+	Missense_Mutation	SNP	G	G	T	rs140646380	byFrequency	TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:189875383G>T	uc002uqj.1	+	50	4138	c.4021G>T	c.(4021-4023)GGC>TGC	p.G1341C		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1341	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GTTTAGCTACGGCAATCCTGA	0.408			NA											37	60					1.15505e-17	1.83631e-17	0.009718	1	0
STAT1	6772	broad.mit.edu	37	2	191841713	191841713	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:191841713C>T	uc002usj.2	-	22	2300	c.1912G>A	c.(1912-1914)GAA>AAA	p.E638K	STAT1_uc010fse.1_Missense_Mutation_p.E638K|STAT1_uc002usk.2_Missense_Mutation_p.E638K|STAT1_uc002usl.2_Missense_Mutation_p.E640K	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	638	SH2.				activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GCAGAAAGTTCTTTCTTCGTG	0.398			NA											15	129					0	0	0.004007	0	0
MYO1B	4430	broad.mit.edu	37	2	192257838	192257838	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:192257838G>T	uc010fsg.2	+	20	2371	c.2116G>T	c.(2116-2118)GAC>TAC	p.D706Y	MYO1B_uc002usq.2_Missense_Mutation_p.D706Y|MYO1B_uc002usr.2_Missense_Mutation_p.D706Y|MYO1B_uc002usu.2_5'UTR	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	706	IQ 1.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ACGCCTGGAGGACTTGGCCAC	0.428			NA											7	70					2.0095e-06	2.41221e-06	0.001984	1	0
PLCL1	5334	broad.mit.edu	37	2	198950213	198950213	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:198950213G>C	uc010fsp.2	+	2	2263	c.1972G>C	c.(1972-1974)GAC>CAC	p.D658H	PLCL1_uc002uuv.3_Missense_Mutation_p.D579H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	658	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GAATCCACAGGACTTTTGGAA	0.413			NA											6	61					0	0	0.000978	0	0
AOX1	316	broad.mit.edu	37	2	201533401	201533401	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:201533401C>A	uc002uvx.2	+	33	3774	c.3673C>A	c.(3673-3675)CAG>AAG	p.Q1225K	AOX1_uc010zhf.1_Missense_Mutation_p.Q781K|AOX1_uc010fsu.2_Missense_Mutation_p.Q591K	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1225					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTATTCTCCCCAGGGCATTCT	0.433			NA											67	127					5.05157e-50	9.44978e-50	0.00361	1	0
ALS2CR11	151254	broad.mit.edu	37	2	202436667	202436667	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:202436667A>G	uc002uye.2	-	8	878	c.830T>C	c.(829-831)GTG>GCG	p.V277A	ALS2CR11_uc002uyf.2_Missense_Mutation_p.V277A|ALS2CR11_uc010fti.2_Missense_Mutation_p.V277A	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	277										large_intestine(1)|ovary(1)|skin(1)	3						CACTTACGTCACGGGATCTGT	0.348			NA											20	37					0	0	0.002299	0	0
NDUFS1	4719	broad.mit.edu	37	2	207003266	207003266	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:207003266C>A	uc002vbe.2	-	13	1462	c.1335G>T	c.(1333-1335)CTG>CTT	p.L445L	NDUFS1_uc010ziq.1_Silent_p.L459L|NDUFS1_uc010zir.1_Silent_p.L409L|NDUFS1_uc010zis.1_Silent_p.L388L|NDUFS1_uc010zit.1_Silent_p.L334L|NDUFS1_uc010ziu.1_Silent_p.L329L	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	445					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	GGGAGTCTCCCAGGTGGTCAT	0.408			NA											18	110					8.00594e-06	9.43841e-06	0.007413	1	0
ERBB4	2066	broad.mit.edu	37	2	212578346	212578346	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:212578346C>A	uc002veg.1	-	8	1009	c.911G>T	c.(910-912)TGT>TTT	p.C304F	ERBB4_uc002veh.1_Missense_Mutation_p.C304F|ERBB4_uc010zji.1_Missense_Mutation_p.C304F|ERBB4_uc010zjj.1_Missense_Mutation_p.C304F|ERBB4_uc010fut.1_Missense_Mutation_p.C304F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	304	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GGCACGCACACAAGAACTGGA	0.358			NA								TSP Lung(8;0.080)			17	20					9.7654e-05	0.000109884	0.007413	1	0
FEV	54738	broad.mit.edu	37	2	219846816	219846816	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:219846816T>A	uc002vji.1	-	3	872	c.290A>T	c.(289-291)AAC>ATC	p.N97I		NM_017521	NP_059991	Q99581	FEV_HUMAN	FEV (ETS oncogene family)	97	ETS.				cell differentiation|nervous system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity		EWSR1/FEV(10)|FUS/FEV(2)	bone(10)|soft_tissue(2)	12		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTTGTCGTAGTTCATGTTGGG	0.642	NSCLC(198;941 2228 4658 24163 34665)		NA	T	EWSR1| FUS	Ewing sarcoma								23	28					0	0	0.002299	0	0
NCL	4691	broad.mit.edu	37	2	232326670	232326670	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:232326670A>G	uc002vru.2	-	3	335	c.194T>C	c.(193-195)GTC>GCC	p.V65A	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	65	1.|8 X 8 AA tandem repeats of X-T-P-X-K-K-X- X.				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		TGGGGAAACGACCACCTTCTT	0.493			NA											8	312					0	0	0.00308	0	0
ESPNL	339768	broad.mit.edu	37	2	239040032	239040032	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:239040032G>T	uc002vxq.3	+	9	2787	c.2677G>T	c.(2677-2679)GGC>TGC	p.G893C	ESPNL_uc010fyw.2_Missense_Mutation_p.G589C	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	893										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GGGCACCCACGGCTGGGAGGC	0.697			NA											10	8					3.07112e-06	3.64235e-06	0.000978	1	0
TMC2	117532	broad.mit.edu	37	20	2597907	2597907	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:2597907G>A	uc002wgf.1	+	16	2145	c.2130G>A	c.(2128-2130)GTG>GTA	p.V710V	TMC2_uc002wgg.1_Silent_p.V694V	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	710	Helical; (Potential).					integral to membrane				ovary(3)	3						TCCTGCCGGTGGCCTACACCA	0.622			NA											15	44					0	0	0.00333	0	0
OXT	5020	broad.mit.edu	37	20	3052311	3052311	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:3052311C>A	uc002wht.1	+	1	46	c.10C>A	c.(10-12)CCC>ACC	p.P4T		NM_000915	NP_000906	P01178	NEU1_HUMAN	oxytocin-neurophysin I preproprotein	4					signal transduction		neurohypophyseal hormone activity				0					Oxytocin(DB00107)	CATGGCCGGCCCCAGCCTCGC	0.692			NA											4	15					2.17888e-05	2.52852e-05	0.006214	1	0
FASTKD5	60493	broad.mit.edu	37	20	3128052	3128052	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:3128052T>A	uc002whz.2	-	2	1976	c.1665A>T	c.(1663-1665)TCA>TCT	p.S555S	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	555					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						ATTCAGGCTTTGAATTCATAT	0.458			NA											33	99					0	0	0.002096	0	0
C20orf194	25943	broad.mit.edu	37	20	3234371	3234371	+	Splice_Site	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:3234371C>A	uc002wii.2	-	36	3472	c.3421_splice	c.e36+1	p.L1141_splice	C20orf194_uc002wij.3_Splice_Site_p.L880_splice|C20orf194_uc002wik.2_Splice_Site_p.L815_splice	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943												0						TCCAAGGATACGTGGGTGAAA	0.507			NA											35	96					3.62531e-18	5.79463e-18	0.004289	1	0
PANK2	80025	broad.mit.edu	37	20	3869922	3869922	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:3869922C>T	uc002wkc.2	+	1	181	c.175C>T	c.(175-177)CGA>TGA	p.R59*	uc002wjz.1_5'Flank|uc002wka.1_5'Flank|PANK2_uc002wkb.2_Intron|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'Flank|PANK2_uc002wkf.2_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	59					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						CAATCCTCCTCGAGTTAGGGA	0.677			NA											7	17					0	0	0.00308	0	0
PLCB1	23236	broad.mit.edu	37	20	8862495	8862495	+	Nonstop_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:8862495G>C	uc002wnb.2	+	32	3653	c.3650G>C	c.(3649-3651)TGA>TCA	p.*1217S	PLCB1_uc002wna.2_3'UTR	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1217					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ACTCCTCTGTGAATGCTCCTG	0.522			NA											17	56					0	0	0.004007	0	0
SLC24A3	57419	broad.mit.edu	37	20	19674054	19674054	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:19674054C>A	uc002wrl.2	+	13	1673	c.1476C>A	c.(1474-1476)TAC>TAA	p.Y492*		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	492	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						CCTTCTCCTACATGATGGTGT	0.488			NA											22	67					2.41591e-17	3.81701e-17	0.004656	1	0
ITCH	83737	broad.mit.edu	37	20	33067498	33067498	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:33067498A>T	uc010geu.1	+	19	2037	c.1845A>T	c.(1843-1845)GCA>GCT	p.A615A	ITCH_uc002xak.2_Silent_p.A574A|ITCH_uc010zuj.1_Silent_p.A464A	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	615	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TTGAATATGCAGGGAAGGATA	0.353			NA											30	56					0	0	0.008361	0	0
CHD6	84181	broad.mit.edu	37	20	40042045	40042045	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:40042045C>T	uc002xka.1	-	35	7228	c.7050G>A	c.(7048-7050)GAG>GAA	p.E2350E	CHD6_uc002xjz.1_5'UTR	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2350					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GAATGGATTTCTCGGCTTGGC	0.592			NA											6	35					0	0	0.00308	0	0
CHD6	84181	broad.mit.edu	37	20	40122580	40122580	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:40122580T>C	uc002xka.1	-	9	1275	c.1097A>G	c.(1096-1098)GAT>GGT	p.D366G	CHD6_uc002xkd.2_Missense_Mutation_p.D344G	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	366					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CAAGTCTTCATCAGGCTAACA	0.488			NA											3	48					0	0	0.004672	0	0
MYBL2	4605	broad.mit.edu	37	20	42344627	42344627	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:42344627G>T	uc002xlb.1	+	14	2218	c.2003G>T	c.(2002-2004)TGC>TTC	p.C668F	MYBL2_uc010zwj.1_Missense_Mutation_p.C644F	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	668						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACGGTGGCCTGCGGGGGGACC	0.622			NA											9	405					5.4927e-09	7.15862e-09	0.004482	1	0
TOX2	84969	broad.mit.edu	37	20	42695474	42695474	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:42695474G>T	uc002xlf.3	+	7	1424	c.1407G>T	c.(1405-1407)GGG>GGT	p.G469G	TOX2_uc010ggo.2_Silent_p.G487G|TOX2_uc002xle.3_Silent_p.G445G|TOX2_uc010ggp.2_Silent_p.G445G|TOX2_uc002xlg.2_Silent_p.G286G|TOX2_uc010zwk.1_Silent_p.G365G	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			ACCCCAGTGGGGAGTGTGGCA	0.642			NA											61	145					1.48005e-37	2.684e-37	0.00361	1	0
HNF4A	3172	broad.mit.edu	37	20	43034856	43034856	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:43034856C>A	uc002xma.2	+	2	363	c.274C>A	c.(274-276)CAC>AAC	p.H92N	HNF4A_uc010zwo.1_Silent_p.T82T|HNF4A_uc002xlt.2_Missense_Mutation_p.H70N|HNF4A_uc002xlu.2_Missense_Mutation_p.H70N|HNF4A_uc002xlv.2_Missense_Mutation_p.H70N|HNF4A_uc002xly.2_Missense_Mutation_p.H92N|HNF4A_uc002xlz.2_Missense_Mutation_p.H92N|HNF4A_uc010ggq.2_Missense_Mutation_p.H85N	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	92	Nuclear receptor.				blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCGGAAGAACCACATGTACTC	0.532	Colon(79;2 1269 8820 14841 52347)		NA											28	57					4.59853e-10	6.12793e-10	0.005443	1	0
ZNF335	63925	broad.mit.edu	37	20	44587938	44587938	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:44587938G>A	uc002xqw.2	-	15	2278	c.2155C>T	c.(2155-2157)CGC>TGC	p.R719C	ZNF335_uc010zxk.1_Missense_Mutation_p.R564C	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	719					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GGGCGACGGCGGGAGGGGGGC	0.657			NA											31	80					0	0	0.003755	0	0
C20orf11	54994	broad.mit.edu	37	20	61576189	61576189	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr20:61576189C>T	uc002ydy.2	+	5	789	c.612C>T	c.(610-612)AAC>AAT	p.N204N		NM_017896	NP_060366	Q9NWU2	CT011_HUMAN	chromosome 20 open reading frame 11	204						nucleus	protein binding				0	Breast(26;5.68e-08)					GGGCTCAGAACGAGCTGGACC	0.473			NA											34	81					0	0	0.002445	0	0
TPTE	7179	broad.mit.edu	37	21	10970037	10970037	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr21:10970037C>A	uc002yip.1	-	6	459	c.91G>T	c.(91-93)GCA>TCA	p.A31S	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.A31S|TPTE_uc002yir.1_Missense_Mutation_p.A31S|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	31					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCTCGGTTGCTCCTTTAAAT	0.393			NA											26	150					1.16021e-09	1.53916e-09	0.007291	1	0
DOPEY2	9980	broad.mit.edu	37	21	37664514	37664514	+	Missense_Mutation	SNP	C	C	G	rs34428315		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr21:37664514C>G	uc002yvg.2	+	36	6707	c.6628C>G	c.(6628-6630)CTA>GTA	p.L2210V	DOPEY2_uc011aeb.1_Missense_Mutation_p.L2159V	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2210					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TCTAGAACTTCTAAAATTAAA	0.284			NA											22	51					0	0	0.010504	0	0
NEFH	4744	broad.mit.edu	37	22	29886353	29886353	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr22:29886353G>A	uc003afo.2	+	4	2795	c.2724G>A	c.(2722-2724)AAG>AAA	p.K908K	NEFH_uc003afp.2_5'UTR	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	914	Tail.				cell death|nervous system development	neurofilament					0						CCCCAGAGAAGGAGGCTCCTG	0.498			NA											6	17					0	0	0.00308	0	0
CTNNB1	1499	broad.mit.edu	37	3	41274850	41274850	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:41274850G>T	uc010hia.1	+	9	1256	c.1100G>T	c.(1099-1101)GGA>GTA	p.G367V	CTNNB1_uc003ckp.2_Missense_Mutation_p.G367V|CTNNB1_uc003ckq.2_Missense_Mutation_p.G367V|CTNNB1_uc003ckr.2_Missense_Mutation_p.G367V|CTNNB1_uc011azf.1_Missense_Mutation_p.G360V|CTNNB1_uc011azg.1_Missense_Mutation_p.G295V|CTNNB1_uc003cks.2_5'Flank|CTNNB1_uc003ckt.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	367	ARM 6.				adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CAAGCTTTAGGACTTCACCTG	0.393	Colon(6;3 56 14213 18255)		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				19	62					3.99206e-14	5.91822e-14	0.007413	1	0
ZBTB47	92999	broad.mit.edu	37	3	42703101	42703101	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:42703101C>T	uc003clu.1	+	2	572	c.470C>T	c.(469-471)GCC>GTC	p.A157V		NM_145166	NP_660149	Q9UFB7	ZBT47_HUMAN	zinc finger protein 651	157	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.216)		TACACCATGGCCCACGTGCGT	0.522			NA											13	45					0	0	0.00245	0	0
Unknown	0	broad.mit.edu	37	3	42982786	42982786	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:42982786C>A	uc003cmm.3	+	3	247	c.102C>A	c.(100-102)GCC>GCA	p.A34A	uc003cmn.3_Silent_p.A34A					SubName: Full=cDNA FLJ51974;												NA						TGGTGCCTGCCGAGAGGGCCT	0.537			NA											3	10					0.004672	0.00501901	0.004672	1	0
SMARCC1	6599	broad.mit.edu	37	3	47663809	47663809	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:47663809C>G	uc003crq.2	-	25	2787	c.2669G>C	c.(2668-2670)AGA>ACA	p.R890T	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.R781T	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	890					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		CTTGATCTTTCTTTCTTCCAC	0.378			NA											53	151					0	0	0.00361	0	0
BSN	8927	broad.mit.edu	37	3	49691797	49691797	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:49691797C>T	uc003cxe.3	+	5	4922	c.4808C>T	c.(4807-4809)TCT>TTT	p.S1603F		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1603					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCGAGTGTGTCTCAGCTGCCC	0.642			NA											13	30					0	0	0.00245	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54913116	54913116	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:54913116G>T	uc003dhf.2	+	19	1830	c.1782G>T	c.(1780-1782)GGG>GGT	p.G594G	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Silent_p.G500G|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Silent_p.G328G|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	594	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGGACAAAGGGGTACATTTTT	0.343			NA											10	31					5.16669e-11	7.10869e-11	0.000978	1	0
ROBO2	6092	broad.mit.edu	37	3	77623840	77623840	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:77623840G>T	uc003dpy.3	+	14	2805	c.2162G>T	c.(2161-2163)GGA>GTA	p.G721V	ROBO2_uc003dpz.2_Missense_Mutation_p.G725V|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.G725V	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	721	Fibronectin type-III 2.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GAGTTCCAAGGAATGGATAGT	0.373			NA											9	26					1.12685e-05	1.31281e-05	0.004482	1	0
VGLL3	389136	broad.mit.edu	37	3	87017756	87017756	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:87017756G>C	uc003dqn.2	-	3	1285	c.921C>G	c.(919-921)AGC>AGG	p.S307R		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CGAATCCCACGCTGGGCACTA	0.418			NA											14	59					0	0	0.003163	0	0
EPHA3	2042	broad.mit.edu	37	3	89391035	89391035	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:89391035G>T	uc003dqy.2	+	5	1326	c.1101G>T	c.(1099-1101)GGG>GGT	p.G367G	EPHA3_uc003dqx.1_Silent_p.G367G|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	367	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AAAAATGTGGGTGGAATATAA	0.488			NA								TSP Lung(6;0.00050)			18	81					1.55795e-14	2.32711e-14	0.001882	1	0
FILIP1L	11259	broad.mit.edu	37	3	99567728	99567728	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:99567728G>C	uc003dtm.2	-	5	3255	c.2792C>G	c.(2791-2793)ACG>AGG	p.T931R	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.T931R|FILIP1L_uc010hpf.2_Missense_Mutation_p.T507R|FILIP1L_uc010hpg.2_Missense_Mutation_p.T691R|FILIP1L_uc003dtn.2_Missense_Mutation_p.T691R|FILIP1L_uc003dtp.1_Missense_Mutation_p.T691R	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	931						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						TGCAGTACTCGTGTAAGAGTG	0.473			NA											85	275					0	0	0.00361	0	0
GPR128	84873	broad.mit.edu	37	3	100328780	100328780	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:100328780T>A	uc003duc.2	+	1	348	c.80T>A	c.(79-81)CTG>CAG	p.L27Q		NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	27	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						ATTTTGGGACTGGGCATCTGG	0.517	Pancreas(87;185 1975 7223 18722)		NA											28	98					0	0	0.009535	0	0
MORC1	27136	broad.mit.edu	37	3	108819263	108819263	+	Splice_Site	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:108819263C>G	uc003dxl.2	-	5	401	c.314_splice	c.e5+1	p.S105_splice	MORC1_uc011bhn.1_Splice_Site_p.S105_splice	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1						cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						AAAATTCTCACCTTTTAAGAC	0.353			NA											5	175					0	0	0.000602	0	0
STXBP5L	9515	broad.mit.edu	37	3	120973837	120973837	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:120973837G>T	uc003eec.3	+	16	1677	c.1537G>T	c.(1537-1539)GAC>TAC	p.D513Y	STXBP5L_uc011bji.1_Missense_Mutation_p.D513Y	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	513					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TGTAGAGGAAGACCCATTTGC	0.363			NA											13	35					1.5842e-08	2.04669e-08	0.001855	1	0
CASR	846	broad.mit.edu	37	3	122002901	122002901	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:122002901C>A	uc003eev.3	+	7	2472	c.2100C>A	c.(2098-2100)AAC>AAA	p.N700K	CASR_uc003eew.3_Missense_Mutation_p.N710K	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	700	Helical; Name=3; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGAAAACCAACCGTGTCCTCC	0.602			NA											29	115					1.7881e-09	2.35632e-09	0.008361	1	0
SEMA5B	54437	broad.mit.edu	37	3	122631831	122631831	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:122631831A>G	uc003efz.1	-	18	2888	c.2584T>C	c.(2584-2586)TGG>CGG	p.W862R	SEMA5B_uc011bju.1_Missense_Mutation_p.W804R|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.W862R|SEMA5B_uc003efy.1_5'Flank	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	862	Extracellular (Potential).|TSP type-1 3.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CAGGACGACCACGGGCCCCAG	0.746			NA											8	25					0	0	0.004482	0	0
NUDT16	131870	broad.mit.edu	37	3	131101022	131101022	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:131101022G>A	uc003eof.2	+	2	213	c.172G>A	c.(172-174)GAG>AAG	p.E58K	uc003eoc.1_5'Flank|NUDT16_uc011bln.1_Missense_Mutation_p.E45K|NUDT16_uc003eog.1_Missense_Mutation_p.E58K	NM_152395	NP_689608	Q96DE0	NUD16_HUMAN	nudix-type motif 16	91	Nudix hydrolase.					nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding				0						TTTCCGCGTGGAGCGCACTGA	0.672			NA											9	27					0	0	0.001882	0	0
MED12L	116931	broad.mit.edu	37	3	151101922	151101922	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:151101922G>A	uc003eyp.2	+	33	4775	c.4737G>A	c.(4735-4737)ACG>ACA	p.T1579T	MED12L_uc011bnz.1_Silent_p.T1439T|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Silent_p.T742T	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1579					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCAATGGAACGTTAGCCTCTG	0.353			NA											4	57					0	0	0.009096	0	0
SI	6476	broad.mit.edu	37	3	164733862	164733862	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:164733862G>C	uc003fei.2	-	32	3828	c.3766C>G	c.(3766-3768)CAG>GAG	p.Q1256E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1256	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCTGTGTACTGAACATCCTGA	0.333			NA								HNSCC(35;0.089)			4	72					0	0	0.009096	0	0
SLC7A14	57709	broad.mit.edu	37	3	170216488	170216488	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:170216488C>A	uc003fgz.2	-	4	1043	c.727G>T	c.(727-729)GAG>TAG	p.E243*	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	243						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AACTGGCCCTCCGCCCAGTAT	0.517			NA											24	65					1.17739e-12	1.6824e-12	0.005443	1	0
ABCC5	10057	broad.mit.edu	37	3	183667663	183667663	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:183667663C>A	uc003fmg.2	-	22	3270	c.3105G>T	c.(3103-3105)CTG>CTT	p.L1035L	ABCC5_uc011bqt.1_Silent_p.L563L|ABCC5_uc010hxl.2_Intron	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1035	Helical; (Potential).|ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCTCCCGAATCAGGACCCTGG	0.557			NA											24	72					2.24059e-21	3.67037e-21	0.00632	1	0
SENP2	59343	broad.mit.edu	37	3	185341817	185341817	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:185341817A>T	uc003fpn.2	+	15	1729	c.1558A>T	c.(1558-1560)AGA>TGA	p.R520*	SENP2_uc011brv.1_Nonsense_Mutation_p.R510*|SENP2_uc011brw.1_Nonsense_Mutation_p.R333*	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	520	Protease.				mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TAAGACCAAAAGAAATAGTGA	0.343			NA											39	116					0	0	0.00874	0	0
AHSG	197	broad.mit.edu	37	3	186335058	186335058	+	Silent	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:186335058G>C	uc003fqk.3	+	4	573	c.492G>C	c.(490-492)GCG>GCC	p.A164A	AHSG_uc003fqj.2_Silent_p.A164A|AHSG_uc003fql.3_Silent_p.A165A|AHSG_uc003fqm.3_Silent_p.A163A|AHSG_uc010hyp.2_Silent_p.A127A	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	164	Cystatin fetuin-A-type 2.			PLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQL -> MVGW QEGANHKNGAGRSQKQEMAEKMVPEVASG (in Ref. 12; AAF69649).	acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		TGCACGCCGCGAAAGCTGCCC	0.592			NA									OREG0015968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	119					0	0	0.004656	0	0
GP5	2814	broad.mit.edu	37	3	194118069	194118069	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:194118069G>A	uc003ftv.1	-	2	974	c.943C>T	c.(943-945)CGC>TGC	p.R315C		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	315	Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		TACCGCAGGCGGCTCAGGTTG	0.726			NA											6	15					0	0	0.001168	0	0
HGFAC	3083	broad.mit.edu	37	4	3444869	3444869	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:3444869A>G	uc003ghc.2	+	3	394	c.391A>G	c.(391-393)AAG>GAG	p.K131E	HGFAC_uc010icw.2_Missense_Mutation_p.K131E	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	131	Fibronectin type-II.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TGCACACAGGAAGTGGTGGGT	0.697			NA											6	20					0	0	0.001168	0	0
ACOX3	8310	broad.mit.edu	37	4	8418165	8418165	+	Silent	SNP	C	C	T	rs35092737	byFrequency	TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:8418165C>T	uc010idk.2	-	2	229	c.84G>A	c.(82-84)GCG>GCA	p.A28A	ACOX3_uc003glc.3_Silent_p.A28A|ACOX3_uc003gld.3_Silent_p.A28A|ACOX3_uc003gle.1_5'Flank	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	28					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AGCTGAAGGACGCTCTTGCTC	0.607			NA											16	132					0	0	0.004007	0	0
GPR125	166647	broad.mit.edu	37	4	22390178	22390178	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:22390178C>A	uc003gqm.1	-	19	3381	c.3116G>T	c.(3115-3117)AGT>ATT	p.S1039I	GPR125_uc010ieo.1_Missense_Mutation_p.S895I|GPR125_uc003gql.1_Missense_Mutation_p.S166I	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	1039	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				GAAGAACGCACTGAAGCTTAA	0.463			NA											53	77					5.73376e-24	9.71462e-24	0.00361	1	0
PDS5A	23244	broad.mit.edu	37	4	39904046	39904046	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:39904046C>T	uc003guv.3	-	13	1960	c.1420G>A	c.(1420-1422)GTC>ATC	p.V474I	PDS5A_uc010ifo.2_Missense_Mutation_p.V434I|PDS5A_uc003guw.3_Missense_Mutation_p.V474I	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	474					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						TTGTGGGGGACAAGATACTGA	0.318			NA											8	68					0	0	0.004482	0	0
PDGFRA	5156	broad.mit.edu	37	4	55131116	55131116	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:55131116C>G	uc003han.3	+	5	990	c.659C>G	c.(658-660)GCT>GGT	p.A220G	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_3'UTR|PDGFRA_uc010igq.1_Missense_Mutation_p.A114G|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	220	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GAAATGGAAGCTCTTAAAACC	0.408	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			88	122					0	0	0.00361	0	0
KDR	3791	broad.mit.edu	37	4	55961743	55961743	+	Splice_Site	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:55961743C>A	uc003has.2	-	20	3119	c.2817_splice	c.e20+1	p.K939_splice	KDR_uc003hat.1_Splice_Site_p.K939_splice	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor						angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGATGACATACCTTGTAGGGG	0.413			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			10	49					3.27435e-08	4.20279e-08	0.00245	1	0
UBA6	55236	broad.mit.edu	37	4	68534382	68534382	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:68534382C>T	uc003hdg.3	-	9	732	c.680G>A	c.(679-681)GGC>GAC	p.G227D	UBA6_uc003hdi.2_Missense_Mutation_p.G227D|UBA6_uc003hdj.2_Missense_Mutation_p.G227D	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	227					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						AGTAACAATGCCAGGATTTGC	0.303			NA											4	23					0	0	0.009096	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535962	69535962	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:69535962G>T	uc011cal.1	-	1	413	c.375C>A	c.(373-375)AAC>AAA	p.N125K		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	125					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						TACAGAGCTTGTTACTGTAGT	0.328			NA											21	94					2.37509e-13	3.46051e-13	0.010504	1	0
UGT2B10	7365	broad.mit.edu	37	4	69879862	69879862	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:69879862T>A	uc011cao.1	-	6	903	c.767A>T	c.(766-768)GAG>GTG	p.E256V	UGT2B10_uc011can.1_Missense_Mutation_p.E172V			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	293					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						CTGTACAAACTCCTCCATTTG	0.408	Melanoma(133;755 1763 25578 26334 46021)		NA											24	90					0	0	0.002299	0	0
GRSF1	2926	broad.mit.edu	37	4	71691024	71691024	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:71691024C>A	uc010iia.1	-	8	1465	c.1382G>T	c.(1381-1383)CGG>CTG	p.R461L	GRSF1_uc011caz.1_Missense_Mutation_p.R343L|GRSF1_uc003hfs.2_Missense_Mutation_p.R299L	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	461	RRM 3.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			AACGTGGGACCGATCCTTGAG	0.443			NA											24	28					1.42536e-11	1.97948e-11	0.004656	1	0
NPFFR2	10886	broad.mit.edu	37	4	72897911	72897911	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:72897911G>T	uc003hgg.2	+	1	391	c.293G>T	c.(292-294)CGG>CTG	p.R98L	NPFFR2_uc010iig.1_5'UTR	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	98	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			AGGGCTCGCCGGGAGAGGTAA	0.622			NA											19	13					1.22574e-08	1.59051e-08	0.002299	1	0
FRAS1	80144	broad.mit.edu	37	4	79402985	79402985	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:79402985A>G	uc003hlb.2	+	57	8911	c.8471A>G	c.(8470-8472)CAT>CGT	p.H2824R		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2819	Calx-beta 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GTTATCCGCCATGGTACTGAC	0.478			NA											163	254					0	0	0.00361	0	0
AGPAT9	84803	broad.mit.edu	37	4	84516068	84516068	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:84516068G>T	uc003how.2	+	8	1027	c.809G>T	c.(808-810)TGG>TTG	p.W270L	AGPAT9_uc003hox.2_Missense_Mutation_p.W270L|AGPAT9_uc003hoy.2_Missense_Mutation_p.W270L	NM_032717	NP_116106	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	270					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			skin(1)	1		Hepatocellular(203;0.114)				CCTCATGTCTGGTTTGAACGC	0.438			NA											39	149					3.33393e-15	5.06929e-15	0.004878	1	0
DMP1	1758	broad.mit.edu	37	4	88583970	88583970	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:88583970C>G	uc003hqv.2	+	6	1144	c.1040C>G	c.(1039-1041)TCA>TGA	p.S347*	DMP1_uc003hqw.2_Nonsense_Mutation_p.S331*	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	347					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GCCAACCTGTCATCTCAAGAG	0.522			NA											5	219					0	0	0.000602	0	0
ALPK1	80216	broad.mit.edu	37	4	113350384	113350384	+	Missense_Mutation	SNP	C	C	T	rs34120296		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:113350384C>T	uc003iap.3	+	10	1154	c.875C>T	c.(874-876)ACG>ATG	p.T292M	ALPK1_uc003ian.3_Missense_Mutation_p.T292M|ALPK1_uc011cfx.1_Missense_Mutation_p.T214M|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Missense_Mutation_p.T120M	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	292							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AGTGCCTATACGCCGCTCTTC	0.557			NA											42	110					0	0	0.00361	0	0
ANK2	287	broad.mit.edu	37	4	114153332	114153332	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:114153332T>A	uc003ibe.3	+	5	500	c.400T>A	c.(400-402)TTA>ATA	p.L134I	ANK2_uc003ibd.3_Missense_Mutation_p.L113I|ANK2_uc003ibf.3_Missense_Mutation_p.L134I|ANK2_uc003ibc.2_Missense_Mutation_p.L110I|ANK2_uc011cgb.1_Missense_Mutation_p.L149I	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	134	ANK 4.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTTTACTCCTTTATACATGGC	0.393			NA											50	95					0	0	0.00361	0	0
ANK2	287	broad.mit.edu	37	4	114274319	114274319	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:114274319C>G	uc003ibe.3	+	38	4645	c.4545C>G	c.(4543-4545)ATC>ATG	p.I1515M	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.I1530M	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1482					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGATTTGATCAAAATGACCG	0.458			NA											22	89					0	0	0.002299	0	0
ADAD1	132612	broad.mit.edu	37	4	123336740	123336740	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:123336740G>T	uc003ieo.2	+	11	1688	c.1456G>T	c.(1456-1458)GTG>TTG	p.V486L	ADAD1_uc003iep.2_Missense_Mutation_p.V475L|ADAD1_uc003ieq.2_Missense_Mutation_p.V468L	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	486	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TTTGGAGATTGTGGATGGCCT	0.333			NA											27	73					8.24728e-16	1.2736e-15	0.004656	1	0
FAT4	79633	broad.mit.edu	37	4	126337745	126337745	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:126337745G>C	uc003ifj.3	+	6	6986	c.6986G>C	c.(6985-6987)CGC>CCC	p.R2329P	FAT4_uc011cgp.1_Missense_Mutation_p.R627P	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2329	Extracellular (Potential).|Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACAAAAGAGCGCTTTGTCTTA	0.338			NA											46	161					0	0	0.002522	0	0
PLK4	10733	broad.mit.edu	37	4	128804445	128804445	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:128804445G>T	uc003ifo.2	+	3	400	c.155G>T	c.(154-156)GGA>GTA	p.G52V	PLK4_uc011cgs.1_Intron|PLK4_uc011cgt.1_Missense_Mutation_p.G11V	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	52	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TACAAAGCAGGAATGGTACAG	0.313	Colon(135;508 1718 19061 31832 42879)		NA											13	41					3.32936e-07	4.12173e-07	0.006122	1	0
GUCY1A3	2982	broad.mit.edu	37	4	156629414	156629414	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:156629414A>G	uc003iov.2	+	6	880	c.344A>G	c.(343-345)GAA>GGA	p.E115G	GUCY1A3_uc003iou.2_Missense_Mutation_p.E115G|GUCY1A3_uc010iqc.2_Missense_Mutation_p.E115G|GUCY1A3_uc003iow.2_Missense_Mutation_p.E115G|GUCY1A3_uc010iqd.2_Missense_Mutation_p.E115G|GUCY1A3_uc003iox.2_Missense_Mutation_p.E115G|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.E115G|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.E115G	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	115					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GAAGACTTTGAAAAAACAATT	0.279			NA											16	40					0	0	0.00499	0	0
FAM198B	51313	broad.mit.edu	37	4	159052134	159052134	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:159052134C>G	uc003ipp.3	-	4	1608	c.1156G>C	c.(1156-1158)GGA>CGA	p.G386R	FAM198B_uc003ipq.3_Missense_Mutation_p.G394R|FAM198B_uc003ipr.3_Missense_Mutation_p.G386R	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	386	Extracellular (Potential).					Golgi membrane|integral to membrane					0						GGTCTGAATCCACAGCAATTT	0.398			NA											11	52					0	0	0.001368	0	0
TKTL2	84076	broad.mit.edu	37	4	164394019	164394019	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:164394019G>T	uc003iqp.3	-	1	1029	c.868C>A	c.(868-870)CCA>ACA	p.P290T		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	290						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGCGATTTTGGTATGAGATTC	0.294			NA											114	403					1.66084e-67	3.15665e-67	0.00361	1	0
SC4MOL	6307	broad.mit.edu	37	4	166258949	166258949	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:166258949A>T	uc003ire.2	+	3	394	c.264A>T	c.(262-264)CCA>CCT	p.P88P	SC4MOL_uc010irb.2_Silent_p.P88P|SC4MOL_uc003irf.2_5'UTR	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	88					cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	AGGATAAGCCAGAGACATGGG	0.343			NA											6	47					0	0	0.001984	0	0
GPM6A	2823	broad.mit.edu	37	4	176573023	176573023	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:176573023A>T	uc003iuf.2	-	4	1307	c.503T>A	c.(502-504)GTG>GAG	p.V168E	GPM6A_uc011ckj.1_Missense_Mutation_p.V161E|GPM6A_uc003iug.2_Missense_Mutation_p.V168E|GPM6A_uc003iuh.2_Missense_Mutation_p.V157E	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	168	Extracellular (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		TGCTCCCTCCACTAATGTGGT	0.458			NA											11	48					0	0	0.001855	0	0
ODZ3	55714	broad.mit.edu	37	4	183651436	183651436	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:183651436C>A	uc003ivd.1	+	14	2706	c.2669C>A	c.(2668-2670)CCA>CAA	p.P890Q	ODZ3_uc003ive.1_Missense_Mutation_p.P296Q	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	890	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TTCCATTACCCAGAATATGGA	0.418			NA											10	62					3.86212e-05	4.4043e-05	0.008291	1	0
ODZ3	55714	broad.mit.edu	37	4	183664485	183664485	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:183664485G>T	uc003ivd.1	+	18	3579	c.3542G>T	c.(3541-3543)GGG>GTG	p.G1181V	ODZ3_uc003ive.1_Missense_Mutation_p.G587V	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1181	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CTAGCTTGTGGGATCGATGGC	0.507			NA											13	35					1.5842e-08	2.04669e-08	0.001855	1	0
FAT1	2195	broad.mit.edu	37	4	187538952	187538952	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr4:187538952C>A	uc003izf.2	-	10	8976	c.8788G>T	c.(8788-8790)GAT>TAT	p.D2930Y		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2930	Extracellular (Potential).|Cadherin 27.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGGGGGTCATCCTCACTCACA	0.463	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			35	106					6.4771e-29	1.12968e-28	0.002522	1	0
AHRR	57491	broad.mit.edu	37	5	434430	434430	+	Silent	SNP	G	G	A	rs111334085		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:434430G>A	uc003jav.2	+	12	1685	c.1641G>A	c.(1639-1641)CCG>CCA	p.P547P	AHRR_uc003jaw.2_Silent_p.P525P|AHRR_uc010isy.2_Silent_p.P375P|AHRR_uc010isz.2_Silent_p.P525P|AHRR_uc003jax.2_Silent_p.P288P|AHRR_uc003jay.2_Silent_p.P385P|AHRR_uc003jaz.2_Silent_p.P146P	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	529					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			TGTGTGGTCCGACGCTGCTGC	0.622			NA											18	76					0	0	0.007413	0	0
SLC9A3	6550	broad.mit.edu	37	5	482774	482774	+	Silent	SNP	G	G	A	rs143761751		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:482774G>A	uc003jbe.2	-	7	1357	c.1245C>T	c.(1243-1245)CGC>CGT	p.R415R	SLC9A3_uc011clx.1_Silent_p.R415R	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	415						cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCACGGCCCCGCGCAGGCCCC	0.612			NA											7	62					0	0	0.001984	0	0
KIAA0947	23379	broad.mit.edu	37	5	5461293	5461293	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:5461293G>T	uc003jdm.3	+	13	2068	c.1846G>T	c.(1846-1848)GGT>TGT	p.G616C		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	616										ovary(1)|central_nervous_system(1)	2						TGATGACTCAGGTGATGGAAT	0.418			NA											44	130					1.03325e-14	1.55907e-14	0.002852	1	0
DNAH5	1767	broad.mit.edu	37	5	13820609	13820609	+	Splice_Site	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:13820609C>A	uc003jfd.2	-	41	6730	c.6688_splice	c.e41-1	p.V2230_splice		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTCTTCAACCTGAAAACATA	0.318			NA							Kartagener_syndrome				27	85					1.7881e-09	2.35632e-09	0.008361	1	0
TRIO	7204	broad.mit.edu	37	5	14461326	14461326	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:14461326A>G	uc003jff.2	+	35	5408	c.5402A>G	c.(5401-5403)AAG>AGG	p.K1801R	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.K1450R|TRIO_uc003jfi.1_Missense_Mutation_p.K104R	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1801					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CACAAGCACAAGAAGAGCCGC	0.706			NA											3	6					0	0	0.009096	0	0
CDH6	1004	broad.mit.edu	37	5	31323317	31323317	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:31323317G>T	uc003jhe.1	+	12	2601	c.2275G>T	c.(2275-2277)GAT>TAT	p.D759Y		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	759	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AGTGACCACGGATGCAGATCA	0.537			NA											28	115					9.39395e-14	1.38229e-13	0.00632	1	0
RXFP3	51289	broad.mit.edu	37	5	33937086	33937086	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:33937086C>A	uc003jic.1	+	1	598	c.241C>A	c.(241-243)CGG>AGG	p.R81R		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	81	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GGCCCGGGTGCGGATTCTCAT	0.687			NA											15	63					2.31682e-05	2.67291e-05	0.003163	1	0
AMACR	23600	broad.mit.edu	37	5	33989433	33989433	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:33989433T>A	uc003jig.2	-	5	996	c.914A>T	c.(913-915)CAT>CTT	p.H305L	AMACR_uc003jih.2_3'UTR|AMACR_uc003jii.2_Missense_Mutation_p.H290L|AMACR_uc003jij.2_Missense_Mutation_p.H305L	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	305					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						GTGATCATGATGAACAACCTC	0.532			NA											44	84					0	0	0.002852	0	0
PRLR	5618	broad.mit.edu	37	5	35084585	35084585	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:35084585G>C	uc003jjm.2	-	5	890	c.360C>G	c.(358-360)GAC>GAG	p.D120E	PRLR_uc003jjg.1_Missense_Mutation_p.D120E|PRLR_uc003jjh.1_Missense_Mutation_p.D120E|PRLR_uc003jji.1_Missense_Mutation_p.D49E|PRLR_uc003jjj.1_Missense_Mutation_p.D120E|PRLR_uc003jjk.1_Missense_Mutation_p.D49E|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_Missense_Mutation_p.D49E	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	120	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity	p.D120G(1)		ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGTAAGTCACGTCCACATAAA	0.438			NA											70	272					0	0	0.00361	0	0
SLC1A3	6507	broad.mit.edu	37	5	36677103	36677103	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:36677103G>T	uc003jkj.3	+	6	1153	c.677G>T	c.(676-678)CGA>CTA	p.R226L	SLC1A3_uc011cox.1_Missense_Mutation_p.R119L|SLC1A3_uc010iuy.2_Missense_Mutation_p.R226L	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	226	Extracellular (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	ACTCTTACCCGAATCACAGAG	0.488			NA											16	58					3.45872e-05	3.98256e-05	0.004007	1	0
NUP155	9631	broad.mit.edu	37	5	37341209	37341209	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:37341209C>A	uc003jku.1	-	11	1347	c.1229G>T	c.(1228-1230)AGA>ATA	p.R410I	NUP155_uc003jkt.1_Missense_Mutation_p.R351I|NUP155_uc010iuz.1_Missense_Mutation_p.R410I	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	410					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATAAAGAGCTCTATGTACTTT	0.353			NA											21	80					1.55795e-14	2.32711e-14	0.001882	1	0
ITGA1	3672	broad.mit.edu	37	5	52211398	52211398	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:52211398G>T	uc003jou.2	+	15	2014	c.1962G>T	c.(1960-1962)GGG>GGT	p.G654G	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Silent_p.G185G	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	654	Extracellular (Potential).|FG-GAP 7.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				TGACTATTGGGGGCCTTGGTG	0.463			NA											82	138					3.59392e-34	6.45817e-34	0.00361	1	0
ADAMTS6	11174	broad.mit.edu	37	5	64569202	64569202	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:64569202C>A	uc003jtp.2	-	12	2399	c.1585G>T	c.(1585-1587)GGG>TGG	p.G529W	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.G150W	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	529	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CACAGTGTCCCCTCAGCTGCT	0.423			NA											46	177					6.31075e-24	1.06618e-23	0.00361	1	0
FCHO2	115548	broad.mit.edu	37	5	72383455	72383455	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:72383455G>A	uc003kcl.2	+	25	2401	c.2285G>A	c.(2284-2286)GGA>GAA	p.G762E	FCHO2_uc011csl.1_Missense_Mutation_p.G729E|FCHO2_uc010izb.2_Missense_Mutation_p.G190E|FCHO2_uc011csn.1_Missense_Mutation_p.G190E	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	762										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		CTTTCAGAAGGACCTAGTAAA	0.423			NA											16	57					0	0	0.003163	0	0
THBS4	7060	broad.mit.edu	37	5	79373964	79373964	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:79373964C>G	uc003kgh.2	+	18	2502	c.2179C>G	c.(2179-2181)CTG>GTG	p.L727V	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	727	TSP type-3 8.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		AGAGGTCACCCTGACCGACTT	0.587			NA											5	51					0	0	0.000602	0	0
VCAN	1462	broad.mit.edu	37	5	82785999	82785999	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:82785999T>A	uc003kii.3	+	3	509	c.153T>A	c.(151-153)ACT>ACA	p.T51T	VCAN_uc003kij.3_Silent_p.T51T|VCAN_uc010jau.2_Silent_p.T51T|VCAN_uc003kik.3_Silent_p.T51T|VCAN_uc003kih.3_Silent_p.T51T	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	51	Ig-like V-type.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CGATGCCTACTTTGCCACCCA	0.438			NA											9	191					0	0	0.006214	0	0
FER	2241	broad.mit.edu	37	5	108281839	108281839	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:108281839G>T	uc003kop.1	+	11	1629	c.1245G>T	c.(1243-1245)AAG>AAT	p.K415N	FER_uc011cvf.1_RNA|FER_uc011cvg.1_Missense_Mutation_p.K240N	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	415					intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		AGGAAAGAAAGGAGAGGCTAT	0.373	Colon(146;1051 1799 9836 27344 47401)		NA											20	17					2.4624e-09	3.23053e-09	0.008871	1	0
AQPEP	206338	broad.mit.edu	37	5	115339077	115339077	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:115339077G>T	uc003kro.2	+	12	2201	c.2037G>T	c.(2035-2037)AAG>AAT	p.K679N	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	679	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						AGGATCCTAAGGTAAGGTTAC	0.294			NA											9	93					0.000274275	0.00030515	0.004482	1	0
PRRC1	133619	broad.mit.edu	37	5	126859188	126859188	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:126859188G>C	uc003kuk.2	+	2	197	c.17G>C	c.(16-18)GGA>GCA	p.G6A	PRRC1_uc003kuj.3_Missense_Mutation_p.G6A	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	6						Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		GAAGAGAGTGGAATAGAGACA	0.378			NA											10	30					0	0	0.006214	0	0
SLC12A2	6558	broad.mit.edu	37	5	127483407	127483407	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:127483407C>T	uc003kus.2	+	11	2031	c.1867C>T	c.(1867-1869)CCC>TCC	p.P623S	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.P623S	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	623	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGTGAGTGCTCCCAAAATATT	0.323			NA											4	35					0	0	0.009096	0	0
FBN2	2201	broad.mit.edu	37	5	127710389	127710389	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:127710389C>A	uc003kuu.2	-	15	2466	c.2027G>T	c.(2026-2028)AGT>ATT	p.S676I	FBN2_uc003kuv.2_Missense_Mutation_p.S643I	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	676	EGF-like 10; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGACCCTTCACTGTTGATGCA	0.507			NA											11	75					1.58986e-06	1.92799e-06	0.008291	1	0
PHF15	23338	broad.mit.edu	37	5	133909338	133909338	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:133909338A>G	uc003kzo.1	+	10	1617	c.1438A>G	c.(1438-1440)AGA>GGA	p.R480G	PHF15_uc011cxt.1_Missense_Mutation_p.R480G|PHF15_uc003kzk.2_Missense_Mutation_p.R496G|PHF15_uc003kzl.2_Missense_Mutation_p.R480G|PHF15_uc003kzm.2_Missense_Mutation_p.R480G|PHF15_uc003kzn.2_Intron|PHF15_uc003kzp.2_Missense_Mutation_p.R188G	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	480					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTCTCAGGTTAGAAATCTGTG	0.512			NA											53	57					0	0	0.00361	0	0
PSD2	84249	broad.mit.edu	37	5	139193210	139193210	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:139193210C>T	uc003leu.1	+	3	893	c.688C>T	c.(688-690)CGC>TGC	p.R230C		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	230					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCAGCAGCCGCTCTGAGAA	0.632			NA											16	11					0	0	0.001882	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181953	140181953	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:140181953C>A	uc003lhf.2	+	1	1171	c.1171C>A	c.(1171-1173)CCC>ACC	p.P391T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.P391T	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	391	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCTGACGCCCCACGTCCC	0.567			NA											60	200					5.10652e-33	9.06637e-33	0.00361	1	0
PCDHB4	56131	broad.mit.edu	37	5	140502030	140502030	+	Silent	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:140502030A>G	uc003lip.1	+	1	450	c.450A>G	c.(448-450)CTA>CTG	p.L150L		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	150	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGGTACTCTATTTCCGTTGC	0.403			NA											6	145					0	0	0.001168	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558219	140558219	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:140558219G>T	uc011dai.1	+	1	790	c.604G>T	c.(604-606)GAC>TAC	p.D202Y	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	202	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAAGCGCTGGACCGAGAGGA	0.532			NA											51	245					1.82294e-38	3.32616e-38	0.00361	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140731096	140731096	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:140731096G>A	uc003ljo.1	+	1	1269	c.1269G>A	c.(1267-1269)AAG>AAA	p.K423K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Silent_p.K423K	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	423	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCGACAAGGGCAAACCAG	0.517			NA											53	41					0	0	0.00361	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799011	140799011	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:140799011G>T	uc003lkn.1	+	1	1730	c.1585G>T	c.(1585-1587)GAG>TAG	p.E529*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Nonsense_Mutation_p.E529*|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	529	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCACCTTCGAGCTCACGCT	0.697			NA											53	57					1.63038e-21	2.68559e-21	0.00361	1	0
PCDHGA12	26025	broad.mit.edu	37	5	140812210	140812210	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:140812210G>T	uc003lkt.1	+	1	2053	c.1884G>T	c.(1882-1884)ACG>ACT	p.T628T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.T628T	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	628	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGCGCACGGCGCGAGCCC	0.687			NA											19	135					1.28384e-07	1.60277e-07	0.001882	1	0
EBF1	1879	broad.mit.edu	37	5	158135059	158135059	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:158135059A>G	uc010jip.2	-	15	1974	c.1672T>C	c.(1672-1674)TTC>CTC	p.F558L	EBF1_uc011ddw.1_Missense_Mutation_p.F426L|EBF1_uc011ddx.1_Missense_Mutation_p.F559L|EBF1_uc003lxl.3_Missense_Mutation_p.F527L	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	558					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTGGTGCGAAAGCACTCTTC	0.622			NA	T	HMGA2	lipoma								9	6					0	0	0.008291	0	0
HMMR	3161	broad.mit.edu	37	5	162909666	162909666	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:162909666C>T	uc003lzf.2	+	13	1583	c.1401C>T	c.(1399-1401)GCC>GCT	p.A467A	HMMR_uc003lzh.2_Silent_p.A468A|HMMR_uc003lzg.2_Silent_p.A452A|HMMR_uc011dem.1_Silent_p.A381A|uc003lzi.2_RNA	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	467						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		CGTTAACAGCCAGTGAGATAG	0.348			NA											9	56					0	0	0.000978	0	0
SLIT3	6586	broad.mit.edu	37	5	168093656	168093656	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:168093656G>T	uc003mab.2	-	36	4795	c.4375C>A	c.(4375-4377)CGC>AGC	p.R1459S	SLIT3_uc010jjg.2_Missense_Mutation_p.R1466S	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1459	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCTGGCGGCGGATCACCTCT	0.607	Ovarian(29;311 847 10864 17279 24903)		NA											14	101					6.31663e-08	8.00376e-08	0.003163	1	0
DOCK2	1794	broad.mit.edu	37	5	169494661	169494661	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:169494661G>T	uc003maf.2	+	45	4695	c.4615G>T	c.(4615-4617)GTC>TTC	p.V1539F	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.V1031F|DOCK2_uc003mah.2_Missense_Mutation_p.V95F	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1539	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGACCCTGCTGTCATGGGAGG	0.547			NA											19	174					1.87028e-06	2.24965e-06	0.001882	1	0
DOCK2	1794	broad.mit.edu	37	5	169508848	169508848	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:169508848C>A	uc003maf.2	+	51	5370	c.5290C>A	c.(5290-5292)CTG>ATG	p.L1764M	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.L1256M|DOCK2_uc003mah.2_Missense_Mutation_p.L320M	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1764					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTTCCAGCCCTGGCGCTCTC	0.632			NA											7	58					0.00185496	0.00202204	0.001855	1	0
FOXI1	2299	broad.mit.edu	37	5	169533120	169533120	+	Silent	SNP	C	C	G	rs146116253		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:169533120C>G	uc003mai.3	+	1	204	c.159C>G	c.(157-159)GGC>GGG	p.G53G	FOXI1_uc003maj.3_Silent_p.G53G	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	53	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGGGGGCGGCGAGTATGGGG	0.692			NA							Pendred_syndrome				8	29					0	0	0.006214	0	0
HMP19	51617	broad.mit.edu	37	5	173491286	173491286	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:173491286A>T	uc003mcx.2	+	3	326	c.181A>T	c.(181-183)AAG>TAG	p.K61*		NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	61	Cytoplasmic (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GAACAAAGGGAAGTTCCGGGT	0.463			NA											53	60					0	0	0.00361	0	0
HMP19	51617	broad.mit.edu	37	5	173534364	173534364	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:173534364G>T	uc003mcx.2	+	5	517	c.372G>T	c.(370-372)CAG>CAT	p.Q124H	HMP19_uc011dfh.1_Missense_Mutation_p.R28M	NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	124	Lumenal (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ACTCCTCCCAGGACCCCAATT	0.592			NA											29	104					5.45727e-16	8.47162e-16	0.008361	1	0
CDHR2	54825	broad.mit.edu	37	5	176011426	176011426	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:176011426T>A	uc003mem.1	+	19	2210	c.2144T>A	c.(2143-2145)GTG>GAG	p.V715E	CDHR2_uc003men.1_Missense_Mutation_p.V715E	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	715	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CTAGTGGGCGTGGTGAAGGCC	0.617			NA											32	228					0	0	0.009535	0	0
UNC5A	90249	broad.mit.edu	37	5	176306803	176306803	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:176306803C>T	uc003mey.2	+	15	2637	c.2445C>T	c.(2443-2445)GGC>GGT	p.G815G		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	815	Death.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCCCAACGGCAACCTCAGCC	0.672			NA											8	73					0	0	0.00308	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178585744	178585744	+	Missense_Mutation	SNP	A	A	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:178585744A>C	uc003mjw.2	-	6	1112	c.1112T>G	c.(1111-1113)TTT>TGT	p.F371C	ADAMTS2_uc011dgm.1_Missense_Mutation_p.F371C	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	371	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGAAGGCCCAAAGTCCTGCCG	0.627			NA											10	192					0	0	0.006214	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178770885	178770885	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:178770885C>T	uc003mjw.2	-	2	417	c.417G>A	c.(415-417)TGG>TGA	p.W139*	ADAMTS2_uc011dgm.1_Nonsense_Mutation_p.W139*	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	139					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TCTCGCCCTGCCACTCCATAG	0.687			NA											3	14					0	0	0.004672	0	0
DSP	1832	broad.mit.edu	37	6	7585490	7585490	+	Silent	SNP	G	G	T	rs35379048	byFrequency	TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:7585490G>T	uc003mxp.1	+	24	8274	c.7995G>T	c.(7993-7995)ACG>ACT	p.T2665T	DSP_uc003mxq.1_Silent_p.T2066T	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2665	Globular 2.|Plectin 15.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACCCAACCACGGGCCAGAAGC	0.577			NA											77	102					2.40943e-26	4.16557e-26	0.00361	1	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726441	25726441	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:25726441C>G	uc003nfc.2	-	1	350	c.315G>C	c.(313-315)CAG>CAC	p.Q105H	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	105					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GGACTCCGCCCTGGGCAATGG	0.507			NA											5	300					0	0	0.001168	0	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726451	25726451	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:25726451G>C	uc003nfc.2	-	1	340	c.305C>G	c.(304-306)ACC>AGC	p.T102S	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	102					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CTGGGCAATGGTCACGCCGCC	0.512			NA											4	285					0	0	0.001168	0	0
OR2W1	26692	broad.mit.edu	37	6	29012092	29012092	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:29012092C>A	uc003nlw.2	-	1	861	c.861G>T	c.(859-861)CCG>CCT	p.P287P		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGTAAATGAGCGGGTTGAGAC	0.423			NA											7	10					8.12818e-05	9.16352e-05	0.001984	1	0
ANKS1A	23294	broad.mit.edu	37	6	35053711	35053711	+	Missense_Mutation	SNP	G	G	T	rs143845391		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:35053711G>T	uc003ojx.3	+	22	3443	c.3301G>T	c.(3301-3303)GCA>TCA	p.A1101S	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Missense_Mutation_p.A642S|ANKS1A_uc010jvp.1_Missense_Mutation_p.A475S	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	1101						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						GAGGAAATCCGCAGTACGTGG	0.622			NA											10	26					1.58986e-06	1.92799e-06	0.008291	1	0
SCUBE3	222663	broad.mit.edu	37	6	35212536	35212536	+	Silent	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:35212536A>G	uc003okf.1	+	18	2355	c.2349A>G	c.(2347-2349)CCA>CCG	p.P783P	SCUBE3_uc003okg.1_Silent_p.P782P|SCUBE3_uc003okh.1_Silent_p.P670P	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	783					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						GCCGCTGTCCAGGAAACACAA	0.577			NA											48	175					0	0	0.00361	0	0
CAPN11	11131	broad.mit.edu	37	6	44150906	44150906	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:44150906G>A	uc003owt.1	+	21	2106	c.2068G>A	c.(2068-2070)GAT>AAT	p.D690N	CAPN11_uc011dvn.1_3'UTR	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	690	Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CAGGTATGCAGATGATGACCT	0.522			NA											33	109					0	0	0.002445	0	0
DEFB112	245915	broad.mit.edu	37	6	50016257	50016257	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:50016257G>T	uc011dws.1	-	1	108	c.108C>A	c.(106-108)ATC>ATA	p.I36I		NM_001037498	NP_001032587	Q30KQ8	DB112_HUMAN	beta-defensin 112 precursor	36					defense response to bacterium	extracellular region				central_nervous_system(1)	1	Lung NSC(77;0.042)					TACCTGTGCTGATTTTCTCTG	0.318			NA											7	51					0.00307968	0.0033265	0.00308	1	0
TPBG	7162	broad.mit.edu	37	6	83074867	83074867	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:83074867C>T	uc003pjn.3	+	3	1125	c.189C>T	c.(187-189)CCC>CCT	p.P63P	TPBG_uc010kbj.2_Silent_p.P63P|TPBG_uc003pjo.2_Silent_p.P63P	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	63	Extracellular (Potential).|LRRNT.				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		ACCAGTGCCCCGCGCTGTGCG	0.557			NA											3	10					0	0	0.004672	0	0
FHL5	9457	broad.mit.edu	37	6	97052766	97052766	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:97052766C>T	uc003pos.1	+	4	705	c.300C>T	c.(298-300)TCC>TCT	p.S100S	FHL5_uc003pot.1_Silent_p.S100S	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	100	LIM zinc-binding 1.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		AGTGCTCCTCCAAGTGCTTCC	0.512			NA											13	33					0	0	0.001368	0	0
THEMIS	387357	broad.mit.edu	37	6	128134882	128134882	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:128134882G>C	uc003qbi.2	-	5	1223	c.904C>G	c.(904-906)CAG>GAG	p.Q302E	THEMIS_uc010kfa.2_Missense_Mutation_p.Q205E|THEMIS_uc011ebt.1_Missense_Mutation_p.Q302E|THEMIS_uc010kfb.2_Missense_Mutation_p.Q267E	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	302	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TTCCCAGGCTGTAAAATGCTT	0.398			NA											35	68					0	0	0.003271	0	0
LAMA2	3908	broad.mit.edu	37	6	129649485	129649485	+	Silent	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:129649485C>G	uc003qbn.2	+	29	4344	c.4239C>G	c.(4237-4239)ACC>ACG	p.T1413T	LAMA2_uc003qbo.2_Silent_p.T1413T	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1413	Laminin EGF-like 14; second part.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGGACCAACCCTGGGCACCT	0.517			NA											38	54					0	0	0.005524	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762209	130762209	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:130762209G>T	uc003qca.2	+	3	1513	c.642G>T	c.(640-642)TCG>TCT	p.S214S	TMEM200A_uc010kfh.2_Silent_p.S214S|TMEM200A_uc010kfi.2_Silent_p.S214S|TMEM200A_uc003qcb.2_Silent_p.S214S	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	214	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCTCTTTCTCGGGTTTTCGGA	0.478			NA											14	34					6.31663e-08	8.00376e-08	0.003163	1	0
MED23	9439	broad.mit.edu	37	6	131937143	131937143	+	Splice_Site	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:131937143C>A	uc003qcs.1	-	10	955	c.781_splice	c.e10-1	p.D261_splice	MED23_uc003qcq.2_Splice_Site_p.D261_splice|MED23_uc003qct.1_Splice_Site_p.D261_splice|MED23_uc011ecb.1_Splice_Site	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a						regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CAAACAGATCCTTTAAAGAAA	0.338			NA											10	13					7.48243e-07	9.2247e-07	0.006214	1	0
TAAR2	9287	broad.mit.edu	37	6	132938808	132938808	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:132938808G>T	uc003qdl.1	-	2	537	c.537C>A	c.(535-537)GTC>GTA	p.V179V	TAAR2_uc010kfr.1_Silent_p.V134V	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	179	Helical; Name=4; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		CCTCTGAGAAGACCACCCCGA	0.463			NA											19	33					2.35188e-11	3.25097e-11	0.006122	1	0
HIVEP2	3097	broad.mit.edu	37	6	143081590	143081590	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:143081590G>A	uc003qjd.2	-	9	6578	c.5835C>T	c.(5833-5835)TCC>TCT	p.S1945S		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1945					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TCACAGGCAAGGAGGAGAATC	0.423	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											8	58					0	0	0.000978	0	0
SHPRH	257218	broad.mit.edu	37	6	146247376	146247376	+	Silent	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:146247376T>A	uc003qlf.2	-	16	3657	c.3258A>T	c.(3256-3258)ATA>ATT	p.I1086I	SHPRH_uc003qld.2_Silent_p.I1095I|SHPRH_uc003qle.2_Silent_p.I1095I|SHPRH_uc003qlg.1_Silent_p.I642I|SHPRH_uc003qlh.2_Silent_p.I11I|SHPRH_uc003qli.1_Silent_p.I11I	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1086					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		AGGTAGGTGGTATCCCTGGGT	0.378			NA											15	37					0	0	0.00499	0	0
GRM1	2911	broad.mit.edu	37	6	146720744	146720744	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:146720744C>A	uc010khw.1	+	8	3039	c.2569C>A	c.(2569-2571)CGC>AGC	p.R857S	GRM1_uc010khv.1_Missense_Mutation_p.R857S|GRM1_uc003qll.2_Missense_Mutation_p.R857S|GRM1_uc011edz.1_Missense_Mutation_p.R857S|GRM1_uc011eea.1_Missense_Mutation_p.R857S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	857	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGATGTTGTCCGCATGCATGT	0.527			NA											12	42					7.03913e-09	9.15395e-09	0.001368	1	0
STXBP5	134957	broad.mit.edu	37	6	147631360	147631360	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:147631360C>T	uc003qlz.2	+	10	1219	c.1058C>T	c.(1057-1059)ACA>ATA	p.T353I	STXBP5_uc010khz.1_Missense_Mutation_p.T353I|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.T24I	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	353	WD 7.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		CTGTGTGAAACACCATACCCA	0.353			NA											11	20					0	0	0.000978	0	0
STXBP5	134957	broad.mit.edu	37	6	147680270	147680270	+	Missense_Mutation	SNP	A	A	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:147680270A>C	uc003qlz.2	+	23	2517	c.2356A>C	c.(2356-2358)ATT>CTT	p.I786L	STXBP5_uc010khz.1_Missense_Mutation_p.I750L|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.I441L	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	786					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TGTAACAAGCATTGACAAAGA	0.418			NA											13	41					0	0	0.001855	0	0
PNLDC1	154197	broad.mit.edu	37	6	160237602	160237602	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:160237602C>A	uc003qsx.1	+	14	1226	c.1055C>A	c.(1054-1056)GCG>GAG	p.A352E	PNLDC1_uc003qsy.1_Missense_Mutation_p.A363E	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	352	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CACGAAGCCGCGTATGATGCC	0.408			NA											77	136					7.83748e-43	1.44786e-42	0.00361	1	0
RBAK	57786	broad.mit.edu	37	7	5103997	5103997	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:5103997C>T	uc010kss.1	+	6	1234	c.910C>T	c.(910-912)CTC>TTC	p.L304F	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.L304F	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	304	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AAAGGGAACCCTCACTGTACA	0.418			NA											18	59					0	0	0.00499	0	0
AHR	196	broad.mit.edu	37	7	17375399	17375399	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:17375399G>C	uc011jxz.1	+	9	1762	c.1149G>C	c.(1147-1149)CAG>CAC	p.Q383H	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	383	PAC.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TTGTAACTCAGAGACCACTAA	0.348			NA											4	31					0	0	0.009096	0	0
PDE1C	5137	broad.mit.edu	37	7	32209435	32209435	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:32209435C>A	uc003tco.1	-	3	864	c.270G>T	c.(268-270)CAG>CAT	p.Q90H		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AGCTATCCAGCTGTGGCAATT	0.483			NA											12	77					4.92203e-23	8.24509e-23	0.00623	1	0
NPSR1	387129	broad.mit.edu	37	7	34867133	34867133	+	Missense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:34867133T>A	uc003teg.1	+	5	727	c.599T>A	c.(598-600)CTG>CAG	p.L200Q	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.L200Q|NPSR1_uc010kwt.1_Missense_Mutation_p.L47Q|NPSR1_uc010kwu.1_5'UTR|NPSR1_uc010kwv.1_Missense_Mutation_p.L134Q|NPSR1_uc003tei.1_Missense_Mutation_p.L200Q|NPSR1_uc010kww.1_Missense_Mutation_p.L189Q|NPSR1_uc011kar.1_Missense_Mutation_p.L134Q|AAA1_uc010kwy.2_Intron|AAA1_uc003tek.3_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	200	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TGCTGGGCCCTGTGGCCTGAC	0.532			NA											17	156					0	0	0.007413	0	0
HECW1	23072	broad.mit.edu	37	7	43447290	43447290	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:43447290A>T	uc003tid.1	+	8	1366	c.761A>T	c.(760-762)AAG>ATG	p.K254M	HECW1_uc011kbi.1_Missense_Mutation_p.K254M|HECW1_uc003tie.1_Missense_Mutation_p.K286M	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	254	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGGAGATCCAAGATCATAGGC	0.522			NA											42	64					0	0	0.002852	0	0
ABCA13	154664	broad.mit.edu	37	7	48318349	48318349	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:48318349G>T	uc003toq.2	+	18	7583	c.7558G>T	c.(7558-7560)GAC>TAC	p.D2520Y	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2520					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CACATCAATGGACTCCATTGT	0.428			NA											108	147					1.13638e-54	2.14609e-54	0.00361	1	0
ABCA13	154664	broad.mit.edu	37	7	48550739	48550739	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:48550739A>T	uc003toq.2	+	51	13609	c.13584A>T	c.(13582-13584)ACA>ACT	p.T4528T	ABCA13_uc010kys.1_Silent_p.T1603T|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Silent_p.T258T	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4528					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCCAGTTAACAGCTTTTACTT	0.458			NA											12	97					0	0	0.001855	0	0
SEPT14	346288	broad.mit.edu	37	7	55912411	55912411	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:55912411C>A	uc003tqz.2	-	4	293	c.176G>T	c.(175-177)GGG>GTG	p.G59V		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	59	GTP (By similarity).				cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCCAGTCTCCCCTGTAATAGA	0.323			NA											4	23					0.000602214	0.000662548	0.000602	1	0
ZNF716	441234	broad.mit.edu	37	7	57529052	57529052	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:57529052C>A	uc011kdi.1	+	4	997	c.885C>A	c.(883-885)CCC>CCA	p.P295P		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						GAGAGAAACCCTACACATGTG	0.413			NA											10	15					1.58986e-06	1.92799e-06	0.008291	1	0
NCF1B	654816	broad.mit.edu	37	7	72645953	72645953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:72645953G>A	uc011kes.1	+	7	717	c.713G>A	c.(712-714)TGG>TAG	p.W238*	FKBP6_uc003twz.2_Intron	NM_000265	NP_000256			neutrophil cytosolic factor 1												0						GACGGCTGGTGGGTCATCAGG	0.597			NA											33	18					0	0	0.00361	0	0
MAGI2	9863	broad.mit.edu	37	7	77789402	77789402	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:77789402C>T	uc003ugx.2	-	16	3039	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K	MAGI2_uc003ugy.2_Missense_Mutation_p.E915K|MAGI2_uc010ldx.1_Missense_Mutation_p.E522K	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	929	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CCGAAGCCCTCATTCTCTTTG	0.532			NA											7	139					0	0	0.00308	0	0
HGF	3082	broad.mit.edu	37	7	81331986	81331986	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:81331986G>T	uc003uhl.2	-	18	2263	c.2098C>A	c.(2098-2100)CCA>ACA	p.P700T	HGF_uc003uhm.2_Missense_Mutation_p.P695T	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	700	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GGACGATTTGGAATGGCACAT	0.398			NA											29	17					1.32181e-22	2.20798e-22	0.007291	1	0
CACNA2D1	781	broad.mit.edu	37	7	81594951	81594951	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:81594951C>A	uc003uhr.1	-	32	2789	c.2533G>T	c.(2533-2535)GGG>TGG	p.G845W	CACNA2D1_uc011kgy.1_Missense_Mutation_p.G57W	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	857	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AGAAGAAACCCACCATCATCC	0.373			NA											5	29					1.23904e-05	1.44069e-05	0.000602	1	0
TFPI2	7980	broad.mit.edu	37	7	93518469	93518469	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:93518469T>C	uc003umy.1	-	3	413	c.338A>G	c.(337-339)TAT>TGT	p.Y113C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Missense_Mutation_p.Y113C|TFPI2_uc003una.1_Missense_Mutation_p.Y102C|TFPI2_uc003unb.1_Missense_Mutation_p.Y113C|TFPI2_uc010lfg.1_Intron	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	113	BPTI/Kunitz inhibitor 2.				blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			ATTAAAGAAATACTTTTCTGT	0.443			NA											55	183					0	0	0.00361	0	0
MUC17	140453	broad.mit.edu	37	7	100677932	100677932	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:100677932G>A	uc003uxp.1	+	3	3288	c.3235G>A	c.(3235-3237)GCC>ACC	p.A1079T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1079	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|16.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TTATTCTCAAGCCAGTTCATC	0.502			NA											335	444					0	0	0.00361	0	0
MUC17	140453	broad.mit.edu	37	7	100685898	100685898	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:100685898C>G	uc003uxp.1	+	3	11254	c.11201C>G	c.(11200-11202)TCT>TGT	p.S3734C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3734	Extracellular (Potential).|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCCATTTCATCTTCTGCAACT	0.507			NA											4	321					0	0	0.009096	0	0
EMID2	136227	broad.mit.edu	37	7	101183242	101183242	+	Silent	SNP	T	T	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:101183242T>G	uc010lhy.1	+	5	702	c.510T>G	c.(508-510)ACT>ACG	p.T170T	EMID2_uc003uyo.1_Silent_p.T172T	NM_133457	NP_597714	Q96A83	EMID2_HUMAN	EMI domain containing 2	172						collagen				ovary(1)	1	Lung NSC(181;0.215)					CCGAGAGCACTCCGCCGACCT	0.657			NA											33	25					0	0	0.004878	0	0
CUX1	1523	broad.mit.edu	37	7	101870904	101870904	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:101870904G>T	uc003uyx.3	+	21	3426	c.3388G>T	c.(3388-3390)GGC>TGC	p.G1130C	CUX1_uc003uys.3_Missense_Mutation_p.G1141C|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	1130	CUT 3.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GGACACCTACGGCATAACCAA	0.607			NA											26	82					3.69857e-22	6.14356e-22	0.008361	1	0
RELN	5649	broad.mit.edu	37	7	103137039	103137039	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:103137039G>T	uc003vca.2	-	56	9287	c.9127C>A	c.(9127-9129)CTG>ATG	p.L3043M	RELN_uc010liz.2_Missense_Mutation_p.L3043M	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3043					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATGTTGTCCAGTGCCCACTGA	0.468	NSCLC(146;835 1944 15585 22231 52158)		NA											54	45					9.86064e-34	1.76657e-33	0.00361	1	0
LRRC4	64101	broad.mit.edu	37	7	127670602	127670602	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:127670602A>G	uc003vmk.2	-	2	229	c.92T>C	c.(91-93)CTG>CCG	p.L31P	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	31						cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GGCTGCACACAGAATCCACAC	0.622			NA											93	54					0	0	0.00361	0	0
HIPK2	28996	broad.mit.edu	37	7	139285223	139285223	+	Missense_Mutation	SNP	C	C	A	rs56132157		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:139285223C>A	uc003vvf.3	-	11	2549	c.2375G>T	c.(2374-2376)CGG>CTG	p.R792L	HIPK2_uc003vvd.3_Missense_Mutation_p.R765L	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	792	Interaction with HMGA1 (By similarity).|Interaction with SKI and SMAD1.|Interaction with POU4F1 (By similarity).|Interaction with CTBP1 (By similarity).		R -> Q.		apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					TGGCTGCTGCCGCATCACGTG	0.567			NA											22	75					1.10923e-09	1.47483e-09	0.00278	1	0
PRSS1	5644	broad.mit.edu	37	7	142459828	142459828	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:142459828C>A	uc003wak.2	+	3	421	c.404C>A	c.(403-405)ACT>AAT	p.T135N	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.T75N	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	135	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CCTCCAGCCACTGGCACGAAG	0.557			NA							Hereditary_Pancreatitis				45	26					1.38705e-31	2.4335e-31	0.00361	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147914552	147914552	+	Silent	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:147914552C>G	uc003weu.1	+	19	3699	c.3183C>G	c.(3181-3183)CCC>CCG	p.P1061P		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1061	Laminin G-like 4.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCAAGGCGCCCTGCATTCTCC	0.567			NA								HNSCC(39;0.1)			41	125					0	0	0.007835	0	0
KCNH2	3757	broad.mit.edu	37	7	150645550	150645550	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:150645550G>C	uc003wic.2	-	11	2687	c.2674C>G	c.(2674-2676)CGC>GGC	p.R892G	KCNH2_uc003wib.2_Missense_Mutation_p.R552G|KCNH2_uc011kux.1_Missense_Mutation_p.R796G	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	892	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GTGCGCCTGCGGAAGGACAAC	0.358	GBM(137;110 1844 13671 20123 45161)		NA											19	47					0	0	0.007413	0	0
DPP6	1804	broad.mit.edu	37	7	153584797	153584797	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:153584797C>T	uc003wli.2	+	1	379	c.29C>T	c.(28-30)GCT>GTT	p.A10V		NM_001039350	NP_001034439	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 3	Error:Variant_position_missing_in_P42658_after_alignment					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			ATCAAGACCGCTAAGATGCAG	0.577	NSCLC(125;1384 1783 2490 7422 34254)		NA											13	68					0	0	0.001855	0	0
HTR5A	3361	broad.mit.edu	37	7	154862701	154862701	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:154862701C>G	uc003wlu.1	+	1	156	c.92C>G	c.(91-93)CCC>CGC	p.P31R	uc011kvt.1_Intron|uc003wlt.2_Intron	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	31	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GACCTGCGCCCCAGCTCGCCC	0.612			NA											32	112					0	0	0.005524	0	0
PTPRN2	5799	broad.mit.edu	37	7	157997861	157997861	+	Splice_Site	SNP	A	A	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr7:157997861A>C	uc003wno.2	-	4	501	c.380_splice	c.e4+1	p.R127_splice	PTPRN2_uc003wnp.2_Splice_Site_p.R110_splice|PTPRN2_uc003wnq.2_Splice_Site_p.R127_splice|PTPRN2_uc003wnr.2_Splice_Site_p.R89_splice|PTPRN2_uc011kwa.1_Splice_Site_p.R150_splice	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N							integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GTCCACACTTACCTGGCTGGG	0.488			NA											18	62					0	0	0.002445	0	0
DLGAP2	9228	broad.mit.edu	37	8	1581027	1581027	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:1581027C>A	uc003wpl.2	+	5	1482	c.1385C>A	c.(1384-1386)TCC>TAC	p.S462Y	DLGAP2_uc003wpm.2_Missense_Mutation_p.S462Y	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	541					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CAATTCGAGTCCGTGTGCGAG	0.567			NA											11	26					2.80697e-09	3.67447e-09	0.000978	1	0
CSMD1	64478	broad.mit.edu	37	8	3432521	3432521	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:3432521C>A	uc011kwk.1	-	10	1683	c.1293G>T	c.(1291-1293)CAG>CAT	p.Q431H		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	431	CUB 3.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATCTTCATACTGAACCGGAT	0.517			NA											18	61					3.32936e-07	4.12173e-07	0.006122	1	0
RP1L1	94137	broad.mit.edu	37	8	10468146	10468146	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:10468146C>A	uc003wtc.2	-	4	3691	c.3462G>T	c.(3460-3462)TCG>TCT	p.S1154S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1154					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		ACAGGTCCTTCGAGATGCTGA	0.587			NA											22	76					9.57634e-11	1.31149e-10	0.00333	1	0
AMAC1L2	83650	broad.mit.edu	37	8	11188891	11188891	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:11188891C>T	uc003wtp.1	+	1	397	c.276C>T	c.(274-276)GAC>GAT	p.D92D		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	92	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		TGCGTGGCGACCCCCTTCTGG	0.592			NA											84	363					0	0	0.00361	0	0
HR	55806	broad.mit.edu	37	8	21976735	21976735	+	Silent	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:21976735C>G	uc003xas.2	-	15	3704	c.3039G>C	c.(3037-3039)CTG>CTC	p.L1013L	HR_uc003xat.2_Silent_p.L1013L	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1013	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGATGCTGACCAGGTCGGCCA	0.602			NA											17	51					0	0	0.00499	0	0
HR	55806	broad.mit.edu	37	8	21977932	21977932	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:21977932G>A	uc003xas.2	-	12	3364	c.2699C>T	c.(2698-2700)GCG>GTG	p.A900V	HR_uc003xat.2_Missense_Mutation_p.A900V	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	900							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGGGCTCAGCGCCTGCACCTG	0.632			NA											33	91					0	0	0.003271	0	0
PIWIL2	55124	broad.mit.edu	37	8	22175745	22175745	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:22175745G>C	uc003xbn.2	+	20	2508	c.2360G>C	c.(2359-2361)AGC>ACC	p.S787T	PIWIL2_uc011kzf.1_Missense_Mutation_p.S787T|PIWIL2_uc010ltv.2_Missense_Mutation_p.S787T	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	787	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		ATTGTGGACAGCCTGAAGCTA	0.448			NA											26	105					0	0	0.008361	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22863618	22863618	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:22863618G>T	uc003xcq.2	+	4	979	c.442G>T	c.(442-444)GAC>TAC	p.D148Y	RHOBTB2_uc003xcp.2_Missense_Mutation_p.D170Y|RHOBTB2_uc011kzp.1_Missense_Mutation_p.D155Y	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	148	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GCGCTACGCTGACCTGGAGGC	0.597			NA											101	372					2.14978e-47	4.00887e-47	0.00361	1	0
FBXO16	157574	broad.mit.edu	37	8	28309761	28309761	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:28309761C>A	uc003xgu.2	-	6	838	c.740G>T	c.(739-741)GGA>GTA	p.G247V	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.G234V|FBXO16_uc003xgw.2_Missense_Mutation_p.G234V	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	247										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		AGCTTCTTACCCTTGCTGGAC	0.403			NA											26	58					2.44723e-14	3.64625e-14	0.004656	1	0
TMEM66	51669	broad.mit.edu	37	8	29924385	29924385	+	Silent	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:29924385A>G	uc003xhs.2	-	4	934	c.750T>C	c.(748-750)TTT>TTC	p.F250F	TMEM66_uc003xht.2_Silent_p.F250F|TMEM66_uc003xhu.2_Silent_p.F214F|TMEM66_uc003xhv.2_Silent_p.F78F	NM_016127	NP_057211	Q96BY9	TMM66_HUMAN	transmembrane protein 66 precursor	250						integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		GTTGTCCTGTAAAAGCACTGC	0.398			NA											63	153					0	0	0.00361	0	0
UNC5D	137970	broad.mit.edu	37	8	35606200	35606200	+	Missense_Mutation	SNP	A	A	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:35606200A>C	uc003xjr.1	+	12	2250	c.1922A>C	c.(1921-1923)CAG>CCG	p.Q641P	UNC5D_uc003xjs.1_Missense_Mutation_p.Q636P|UNC5D_uc003xju.1_Missense_Mutation_p.Q217P	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	641	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AGGACACAGCAGGGCAAATGG	0.438			NA											29	85					0	0	0.002096	0	0
KCNU1	157855	broad.mit.edu	37	8	36691143	36691143	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:36691143C>G	uc010lvw.2	+	11	1265	c.1178C>G	c.(1177-1179)TCT>TGT	p.S393C	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	393	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATTTCTGGATCTGCAATGAAG	0.398			NA											9	26					0	0	0.008291	0	0
KCNU1	157855	broad.mit.edu	37	8	36694374	36694374	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:36694374G>T	uc010lvw.2	+	14	1516	c.1429G>T	c.(1429-1431)GAA>TAA	p.E477*	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	477	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CTGCTTTGCTGAATTAAAACT	0.433			NA											35	111					8.4185e-14	1.24493e-13	0.002445	1	0
ANK1	286	broad.mit.edu	37	8	41551533	41551533	+	Missense_Mutation	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:41551533G>A	uc003xok.2	-	29	3499	c.3415C>T	c.(3415-3417)CGG>TGG	p.R1139W	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.R455W|ANK1_uc003xoi.2_Missense_Mutation_p.R1139W|ANK1_uc003xoj.2_Missense_Mutation_p.R1139W|ANK1_uc003xol.2_Missense_Mutation_p.R1139W|ANK1_uc003xom.2_Missense_Mutation_p.R1180W	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1139					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGGAACTTCCGGCGCCGGGGC	0.642			NA											17	66					0	0	0.006122	0	0
ANK1	286	broad.mit.edu	37	8	41553923	41553923	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:41553923C>A	uc003xok.2	-	26	3002	c.2918G>T	c.(2917-2919)AGC>ATC	p.S973I	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.S289I|ANK1_uc003xoi.2_Missense_Mutation_p.S973I|ANK1_uc003xoj.2_Missense_Mutation_p.S973I|ANK1_uc003xol.2_Missense_Mutation_p.S973I|ANK1_uc003xom.2_Missense_Mutation_p.S1014I	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	973	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TATGATCCTGCTGGCCAGGCC	0.716			NA											31	61					1.22384e-17	1.94047e-17	0.002836	1	0
ANK1	286	broad.mit.edu	37	8	41581079	41581079	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:41581079C>A	uc003xok.2	-	8	868	c.784G>T	c.(784-786)GGA>TGA	p.G262*	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Nonsense_Mutation_p.G262*|ANK1_uc003xoj.2_Nonsense_Mutation_p.G262*|ANK1_uc003xol.2_Nonsense_Mutation_p.G262*|ANK1_uc003xom.2_Nonsense_Mutation_p.G295*	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	262	ANK 7.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ATCTGGGCTCCCCGATCCAGC	0.652			NA											23	75					1.10513e-12	1.58296e-12	0.002299	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766283	77766283	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:77766283G>C	uc003yav.2	+	10	7378	c.6991G>C	c.(6991-6993)GCT>CCT	p.A2331P	ZFHX4_uc003yau.1_Missense_Mutation_p.A2376P|ZFHX4_uc003yaw.1_Missense_Mutation_p.A2331P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2331						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCTAAAAACGCTGCTGCCCC	0.512			NA								HNSCC(33;0.089)			46	117					0	0	0.00361	0	0
ZFAND1	79752	broad.mit.edu	37	8	82615028	82615028	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:82615028T>A	uc003ycj.1	-	8	723	c.709A>T	c.(709-711)AAG>TAG	p.K237*	ZFAND1_uc010lzx.1_Nonsense_Mutation_p.K230*|ZFAND1_uc003yck.1_Nonsense_Mutation_p.K130*	NM_024699	NP_078975	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	237							zinc ion binding			ovary(1)	1						CAATCCTCCTTAGCAATCCAG	0.353			NA											41	108					0	0	0.003214	0	0
RGS22	26166	broad.mit.edu	37	8	101075826	101075826	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:101075826C>G	uc003yjb.1	-	8	1365	c.1170G>C	c.(1168-1170)GAG>GAC	p.E390D	RGS22_uc003yja.1_Missense_Mutation_p.E209D|RGS22_uc003yjc.1_Missense_Mutation_p.E378D|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	390					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			GTCCAGCGCTCTCATTCTTTG	0.358			NA											6	81					0	0	0.001168	0	0
CSMD3	114788	broad.mit.edu	37	8	113657364	113657364	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:113657364C>T	uc003ynu.2	-	20	3443	c.3284G>A	c.(3283-3285)TGG>TAG	p.W1095*	CSMD3_uc003yns.2_Nonsense_Mutation_p.W367*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.W1055*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.W991*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1095	Extracellular (Potential).|CUB 6.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATCAACAGTCCATGTACAATT	0.358			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			3	12					0	0	0.009096	0	0
TRPS1	7227	broad.mit.edu	37	8	116430678	116430678	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:116430678C>T	uc003ynz.2	-	5	3123	c.2664G>A	c.(2662-2664)AGG>AGA	p.R888R	TRPS1_uc011lhy.1_Silent_p.R892R|TRPS1_uc003yny.2_Silent_p.R901R|TRPS1_uc010mcy.2_Silent_p.R888R	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	888					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGCCTCTACGCCTCTGAAACA	0.473			NA							Langer-Giedion_syndrome				24	82					0	0	0.003954	0	0
TRPS1	7227	broad.mit.edu	37	8	116631413	116631413	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:116631413C>A	uc003ynz.2	-	2	1332	c.873G>T	c.(871-873)CTG>CTT	p.L291L	TRPS1_uc011lhy.1_Silent_p.L295L|TRPS1_uc003yny.2_Silent_p.L304L|TRPS1_uc010mcy.2_Silent_p.L291L	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	291					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGATGTCCTGCAGCACACCAG	0.418			NA							Langer-Giedion_syndrome				19	48					3.51602e-12	4.95249e-12	0.008871	1	0
COL14A1	7373	broad.mit.edu	37	8	121170441	121170441	+	Missense_Mutation	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:121170441G>C	uc003yox.2	+	3	426	c.161G>C	c.(160-162)AGA>ACA	p.R54T		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	54	Fibronectin type-III 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AAGGCTCCAAGAGGGAAATTT	0.363			NA											14	47					0	0	0.00245	0	0
ZFP41	286128	broad.mit.edu	37	8	144332252	144332252	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:144332252C>T	uc003yxw.2	+	2	597	c.239C>T	c.(238-240)CCT>CTT	p.P80L	ZFP41_uc003yxv.2_RNA	NM_173832	NP_776193	Q8N8Y5	ZFP41_HUMAN	zinc finger protein 41 homolog	80					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GTGTTCATTCCTTTTCAGAGG	0.512			NA											48	113					0	0	0.00361	0	0
FAM83H	286077	broad.mit.edu	37	8	144808840	144808840	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:144808840G>T	uc003yzk.2	-	5	2860	c.2791C>A	c.(2791-2793)CCG>ACG	p.P931T	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	931					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTGCGCTCCGGCACGGGGGGC	0.736			NA											7	6					8.12818e-05	9.16352e-05	0.001984	1	0
PLEC	5339	broad.mit.edu	37	8	144998070	144998070	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:144998070C>A	uc003zaf.1	-	31	6608	c.6438G>T	c.(6436-6438)GAG>GAT	p.E2146D	PLEC_uc003zab.1_Missense_Mutation_p.E2009D|PLEC_uc003zac.1_Missense_Mutation_p.E2013D|PLEC_uc003zad.2_Missense_Mutation_p.E2009D|PLEC_uc003zae.1_Missense_Mutation_p.E1977D|PLEC_uc003zag.1_Missense_Mutation_p.E1987D|PLEC_uc003zah.2_Missense_Mutation_p.E1995D|PLEC_uc003zaj.2_Missense_Mutation_p.E2036D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2146	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCTCGACTTCCTCCAGCGCCG	0.756			NA											3	10					0.00307968	0.0033265	0.00308	1	0
MAF1	84232	broad.mit.edu	37	8	145160669	145160669	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr8:145160669G>T	uc003zbc.1	+	2	584	c.83G>T	c.(82-84)AGG>ATG	p.R28M	SHARPIN_uc003zba.2_5'Flank|SHARPIN_uc003zbb.2_5'Flank|KIAA1875_uc003zbd.3_5'Flank	NM_032272	NP_115648	Q9H063	MAF1_HUMAN	MAF1 protein	28					negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	cytoplasm|nucleus					0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.1e-42)|Epithelial(56;1.23e-40)|all cancers(56;4.84e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATCATTGGCAGGTGAGGCAGG	0.562			NA											21	74					3.01185e-09	3.93398e-09	0.003954	1	0
KIAA1432	57589	broad.mit.edu	37	9	5762559	5762559	+	Missense_Mutation	SNP	A	A	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:5762559A>G	uc003zji.2	+	17	1867	c.1774A>G	c.(1774-1776)ATT>GTT	p.I592V	KIAA1432_uc003zjh.2_Missense_Mutation_p.I592V|KIAA1432_uc003zjl.3_Missense_Mutation_p.I555V|KIAA1432_uc003zjj.1_Missense_Mutation_p.I134V	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	671						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGCAGAGAGCATTATGTTAAA	0.458			NA											36	103					0	0	0.004878	0	0
FREM1	158326	broad.mit.edu	37	9	14812842	14812842	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:14812842A>T	uc003zlm.2	-	16	3451	c.2861T>A	c.(2860-2862)GTT>GAT	p.V954D	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	954	CSPG 6.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CTCTGAGATAACATCTCTCTG	0.507			NA											78	206					0	0	0.00361	0	0
C9orf93	203238	broad.mit.edu	37	9	15591483	15591483	+	Missense_Mutation	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:15591483A>T	uc003zmd.2	+	5	787	c.472A>T	c.(472-474)ATG>TTG	p.M158L	C9orf93_uc010mih.1_Missense_Mutation_p.M158L|C9orf93_uc003zme.2_Missense_Mutation_p.M65L|C9orf93_uc011lmu.1_Missense_Mutation_p.M158L|C9orf93_uc003zmc.2_Missense_Mutation_p.M158L	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	158	Potential.|Glu-rich.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		AAGAGACAATATGATCCAAAA	0.318			NA											3	36					0	0	0.004672	0	0
DDX58	23586	broad.mit.edu	37	9	32487951	32487951	+	Silent	SNP	G	G	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:32487951G>A	uc003zra.2	-	8	1362	c.1204C>T	c.(1204-1206)CTG>TTG	p.L402L	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Silent_p.L357L|DDX58_uc011lnr.1_Silent_p.L199L|DDX58_uc010mji.2_Silent_p.L331L	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	402	Helicase ATP-binding.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		ACCTGGGGCAGTGGGCCTGAA	0.403			NA											20	62					0	0	0.010504	0	0
SIT1	27240	broad.mit.edu	37	9	35650214	35650214	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:35650214G>T	uc003zxe.1	-	4	421	c.324C>A	c.(322-324)GAC>GAA	p.D108E	SIT1_uc003zxf.1_RNA	NM_014450	NP_055265	Q9Y3P8	SIT1_HUMAN	SHP2-interacting transmembrane adaptor protein	108	Cytoplasmic (Potential).				regulation of T cell activation|signal transduction	integral to plasma membrane	kinase binding|SH2 domain binding				0			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GATCCTGCTGGTCTGGCTCTG	0.617			NA											21	80					2.21704e-12	3.13771e-12	0.00278	1	0
TLN1	7094	broad.mit.edu	37	9	35718871	35718871	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:35718871C>A	uc003zxt.2	-	17	2287	c.1933G>T	c.(1933-1935)GGC>TGC	p.G645C		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	645					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGGCCTGGCCCACGTTCCCA	0.572			NA											10	25					1.58986e-06	1.92799e-06	0.008291	1	0
ALDH1B1	219	broad.mit.edu	37	9	38395968	38395969	+	Missense_Mutation	DNP	GA	GA	TG			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:38395968_38395969GA>TG	uc004aay.2	+	2	335_336	c.223_224GA>TG	c.(223-225)GAT>TGT	p.D75C		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	75					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	TGACCGGGCTGATGTGGATCGG	0.644			NA											41	123					0	0	0.004672	0	0
FAM75A6	389730	broad.mit.edu	37	9	43629263	43629263	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:43629263C>G	uc011lrb.1	-	2	276	c.247G>C	c.(247-249)GCT>CCT	p.A83P		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	83						integral to membrane					0						AGAGCCTTACCTCTCAGACTG	0.547			NA											65	72					0	0	0.00361	0	0
APBA1	320	broad.mit.edu	37	9	72082745	72082745	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:72082745C>A	uc004ahh.2	-	5	1752	c.1476G>T	c.(1474-1476)AGG>AGT	p.R492S		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	492	PID.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TCACCTTGATCCTGCTTACGG	0.527			NA											15	141					4.72057e-08	6.00708e-08	0.003954	1	0
TRPM3	80036	broad.mit.edu	37	9	73399169	73399169	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:73399169C>A	uc004aid.2	-	7	1244	c.1000G>T	c.(1000-1002)GCA>TCA	p.A334S	TRPM3_uc004ahu.2_Missense_Mutation_p.A164S|TRPM3_uc004ahv.2_Missense_Mutation_p.A164S|TRPM3_uc004ahw.2_Missense_Mutation_p.A206S|TRPM3_uc004ahx.2_Missense_Mutation_p.A181S|TRPM3_uc004ahy.2_Missense_Mutation_p.A206S|TRPM3_uc004ahz.2_Missense_Mutation_p.A181S|TRPM3_uc004aia.2_Missense_Mutation_p.A181S|TRPM3_uc004aib.2_Missense_Mutation_p.A181S|TRPM3_uc004aic.2_Missense_Mutation_p.A334S|TRPM3_uc010mor.2_Missense_Mutation_p.A334S|TRPM3_uc004aie.2_Missense_Mutation_p.A181S|TRPM3_uc004aif.2_Missense_Mutation_p.A206S|TRPM3_uc004aig.2_Missense_Mutation_p.A181S	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	359	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						ACTATGAGTGCCACCACAGGA	0.418			NA											10	30					0.000978159	0.00107416	0.000978	1	0
TMEM2	23670	broad.mit.edu	37	9	74300223	74300223	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:74300223C>A	uc011lsa.1	-	24	4582	c.4042G>T	c.(4042-4044)GTG>TTG	p.V1348L	TMEM2_uc011lrz.1_Missense_Mutation_p.V341L|TMEM2_uc010mos.2_Missense_Mutation_p.V1285L|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_Missense_Mutation_p.V182L	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1348						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGTTCAAGCACCCCAAGGCCC	0.443			NA											38	84					6.70999e-13	9.65782e-13	0.004289	1	0
Unknown	0	broad.mit.edu	37	9	78937970	78937970	+	Missense_Mutation	SNP	T	T	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:78937970T>G	uc004akc.1	+	4	500	c.280T>G	c.(280-282)TGC>GGC	p.C94G						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.												NA						TTTCCCAGAGTGCACGCCTGA	0.547			NA											4	14					0	0	0.009096	0	0
TSTD2	158427	broad.mit.edu	37	9	100364923	100364923	+	Missense_Mutation	SNP	T	T	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:100364923T>C	uc004axn.2	-	10	1867	c.1379A>G	c.(1378-1380)CAA>CGA	p.Q460R	TSTD2_uc004axo.2_Missense_Mutation_p.Q234R	NM_139246	NP_640339	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like	460										ovary(2)	2						CCCCTTGTCTTGACATGTGAC	0.537			NA											6	310					0	0	0.004482	0	0
RNF20	56254	broad.mit.edu	37	9	104319803	104319803	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:104319803G>T	uc004bbn.2	+	16	2397	c.2307G>T	c.(2305-2307)AAG>AAT	p.K769N		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	769	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AGCGTATCAAGTCCAATCAGA	0.453			NA											12	42					5.16669e-11	7.10869e-11	0.000978	1	0
OR13C4	138804	broad.mit.edu	37	9	107288801	107288801	+	Silent	SNP	C	C	T	rs146391633		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:107288801C>T	uc011lvn.1	-	1	690	c.690G>A	c.(688-690)TCG>TCA	p.S230S		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTCCTGTGGCCGAGTTCGTTC	0.413			NA											33	101					0	0	0.00623	0	0
SUSD1	64420	broad.mit.edu	37	9	114820914	114820914	+	Missense_Mutation	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:114820914C>T	uc004bfu.2	-	14	1944	c.1903G>A	c.(1903-1905)GAT>AAT	p.D635N	SUSD1_uc010mui.2_Missense_Mutation_p.D635N|SUSD1_uc010muj.2_Missense_Mutation_p.D635N	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	635	Extracellular (Potential).					integral to membrane	calcium ion binding				0						CCTTCAGAATCACAAGAAAAT	0.488			NA											19	121					0	0	0.007413	0	0
PTGS1	5742	broad.mit.edu	37	9	125145835	125145835	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:125145835G>T	uc004bmg.1	+	8	945	c.810G>T	c.(808-810)GTG>GTT	p.V270V	PTGS1_uc011lys.1_Silent_p.V245V|PTGS1_uc010mwb.1_Silent_p.V161V|PTGS1_uc004bmf.1_Silent_p.V270V|PTGS1_uc004bmh.1_Silent_p.V161V|PTGS1_uc011lyt.1_Silent_p.V161V	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	270					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	AGGCGCCTGTGTTGATGCACT	0.642			NA											10	53					1.61879e-10	2.19667e-10	0.001368	1	0
C9orf98	158067	broad.mit.edu	37	9	135602879	135602879	+	Silent	SNP	C	C	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:135602879C>T	uc004cbu.1	-	12	1720	c.1164G>A	c.(1162-1164)CGG>CGA	p.R388R	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Silent_p.R184R	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	388	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		TCAGAGTCAGCCGCTCCATGA	0.403			NA											4	161					0	0	0.009096	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138713801	138713801	+	Silent	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr9:138713801C>A	uc004cgr.3	-	11	2706	c.2706G>T	c.(2704-2706)CTG>CTT	p.L902L	CAMSAP1_uc004cgq.3_Silent_p.L792L|CAMSAP1_uc010nbg.2_Silent_p.L624L	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	902						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GCCTTGCCGACAGCGCCTCCA	0.637			NA											49	119					2.47907e-22	4.12946e-22	0.00361	1	0
CPXCR1	53336	broad.mit.edu	37	X	88008704	88008704	+	Missense_Mutation	SNP	C	C	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:88008704C>G	uc004efd.3	+	3	548	c.289C>G	c.(289-291)CCC>GCC	p.P97A	CPXCR1_uc004efc.3_Missense_Mutation_p.P97A	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	97						intracellular	zinc ion binding			ovary(3)	3						GACCCCCATTCCCAGAAAATT	0.413			NA											8	13					0	0	0.00308	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177108	89177108	+	Silent	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:89177108G>T	uc004efe.2	+	2	73	c.24G>T	c.(22-24)CCG>CCT	p.P8P		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	8						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CGGACGGCCCGGCTGAGACCC	0.527			NA											32	59					9.80977e-26	1.68127e-25	0.004289	1	0
RGAG1	57529	broad.mit.edu	37	X	109694400	109694400	+	Silent	SNP	A	A	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:109694400A>T	uc004eor.1	+	3	801	c.555A>T	c.(553-555)TCA>TCT	p.S185S	RGAG1_uc011msr.1_Silent_p.S185S	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	185										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TGAGCACTTCATCCTCTGAGG	0.473			NA											4	213					0	0	0.009096	0	0
ODZ1	10178	broad.mit.edu	37	X	124097430	124097430	+	Missense_Mutation	SNP	T	T	G			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:124097430T>G	uc004euj.2	-	1	237	c.173A>C	c.(172-174)AAT>ACT	p.N58T	ODZ1_uc011muj.1_Missense_Mutation_p.N58T|ODZ1_uc010nqy.2_Missense_Mutation_p.N58T	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	58	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						ACTCTGGCTATTGTAATTCAT	0.368			NA											109	164					0	0	0.00361	0	0
FRMD7	90167	broad.mit.edu	37	X	131228118	131228118	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:131228118G>T	uc004ewn.2	-	5	512	c.334C>A	c.(334-336)CCA>ACA	p.P112T	FRMD7_uc011muy.1_Missense_Mutation_p.P97T	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	112	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TCACTGCATGGAAGCCTTCCT	0.403			NA											74	113					1.43161e-34	2.58038e-34	0.00361	1	0
MAGEA10	4109	broad.mit.edu	37	X	151303881	151303881	+	Missense_Mutation	SNP	G	G	T			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:151303881G>T	uc004ffk.2	-	5	620	c.212C>A	c.(211-213)CCA>CAA	p.P71Q	MAGEA10_uc004ffl.2_Missense_Mutation_p.P71Q	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	71											0	Acute lymphoblastic leukemia(192;6.56e-05)					AACCTCCTCTGGGGTGCTTGG	0.388			NA											112	163					2.68928e-46	4.98357e-46	0.00361	1	0
L1CAM	3897	broad.mit.edu	37	X	153130579	153130579	+	Missense_Mutation	SNP	C	C	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:153130579C>A	uc004fjb.2	-	21	2944	c.2836G>T	c.(2836-2838)GGC>TGC	p.G946C	L1CAM_uc004fjc.2_Missense_Mutation_p.G946C|L1CAM_uc010nuo.2_Missense_Mutation_p.G941C	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	946	Extracellular (Potential).|Fibronectin type-III 4.		Missing (in HSAS).		axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGAGCACGCCGTTGTGGCTG	0.711			NA											10	18					1.15088e-07	1.44285e-07	0.004007	1	0
FLNA	2316	broad.mit.edu	37	X	153588257	153588257	+	Silent	SNP	G	G	C			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:153588257G>C	uc004fkk.2	-	23	4071	c.3822C>G	c.(3820-3822)GCC>GCG	p.A1274A	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Silent_p.A1274A	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1274	Filamin 11.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACTCAGTGGTGGCCTCACGGA	0.657			NA											41	62					0	0	0.00361	0	0
UBXN11	91544	broad.mit.edu	37	1	26608820	26608843	+	In_Frame_Del	DEL	GGGACTGGGGCCGGGACCGGGACC	GGGACTGGGGCCGGGACCGGGACC	-	rs61775084	by1000genomes	TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	GGGACTGGGGCCGGGACCGGGACC	GGGACTGGGGCCGGGACCGGGACC	-	-	GGGACTGGGGCCGGGACCGGGACC	GGGACTGGGGCCGGGACCGGGACC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:26608820_26608843delGGGACTGGGGCCGGGACCGGGACC	uc001blw.2	-	16	1783_1806	c.1510_1533delGGTCCCGGTCCCGGCCCCAGTCCC	c.(1510-1533)GGTCCCGGTCCCGGCCCCAGTCCCdel	p.GPGPGPSP504del	UBXN11_uc001blz.1_Splice_Site_p.I469_splice|UBXN11_uc001blv.2_In_Frame_Del_p.GPGPGPSP466del|UBXN11_uc001bly.2_In_Frame_Del_p.GPGPGPSP384del|UBXN11_uc001blx.2_In_Frame_Del_p.GPGPGPSP262del|UBXN11_uc001bma.2_In_Frame_Del_p.GPGPGPSP471del	NM_183008	NP_892120	Q5T124	UBX11_HUMAN	socius isoform 2	504_511	Pro-rich.					cytoplasm|cytoskeleton				ovary(1)	1						gtccaggacagggactggggccgggaccgggaccgggactgggg	0.312			NA											11	86	---	---	---	---	NA	NA	NA	NA	NA
LHX8	431707	broad.mit.edu	37	1	75596416	75596416	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:75596416delG	uc001dgo.2	+	2	681	c.17delG	c.(16-18)AGGfs	p.R6fs	uc001dgp.1_RNA	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	6						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						ATTCTGAGCAGGGTAAGTTTG	0.448			NA											59	183	---	---	---	---	NA	NA	NA	NA	NA
ASTN1	460	broad.mit.edu	37	1	176927566	176927566	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:176927566delC	uc001glc.2	-	10	1863	c.1651delG	c.(1651-1653)GTGfs	p.V551fs	ASTN1_uc001glb.1_Frame_Shift_Del_p.V551fs|ASTN1_uc001gld.1_Frame_Shift_Del_p.V551fs|ASTN1_uc009wwx.1_Frame_Shift_Del_p.V551fs	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	559					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GGTGGAATCACAAAGCTCTTG	0.557			NA											25	61	---	---	---	---	NA	NA	NA	NA	NA
FMN2	56776	broad.mit.edu	37	1	240371236	240371236	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr1:240371236delC	uc010pyd.1	+	5	3349	c.3124delC	c.(3124-3126)CCCfs	p.P1042fs	FMN2_uc010pye.1_Frame_Shift_Del_p.P1046fs	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1042	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGCGGGCATACCCCCTCCGCC	0.726			NA											3	6	---	---	---	---	NA	NA	NA	NA	NA
OR4C16	219428	broad.mit.edu	37	11	55339717	55339717	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:55339717delG	uc010rih.1	+	1	114	c.114delG	c.(112-114)TTGfs	p.L38fs		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GAACACTGTTGGGTAATTTGC	0.373			NA											41	164	---	---	---	---	NA	NA	NA	NA	NA
OR5R1	219479	broad.mit.edu	37	11	56185244	56185244	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr11:56185244delA	uc010rji.1	-	1	465	c.465delT	c.(463-465)GTTfs	p.V155fs		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGAAGAGGGCAACCAGGAAGC	0.453			NA											25	59	---	---	---	---	NA	NA	NA	NA	NA
TPCN1	53373	broad.mit.edu	37	12	113711406	113711406	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr12:113711406delG	uc001tuw.2	+	10	1172	c.875delG	c.(874-876)CGGfs	p.R292fs	TPCN1_uc001tux.2_Frame_Shift_Del_p.R364fs|TPCN1_uc010syt.1_Frame_Shift_Del_p.R224fs	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	292	Extracellular (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TCCTACTCCCGGAACCCCTGG	0.537			NA											79	262	---	---	---	---	NA	NA	NA	NA	NA
PPP2R5E	5529	broad.mit.edu	37	14	64006248	64006248	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:64006248delT	uc001xgd.1	-	2	746	c.156delA	c.(154-156)AAAfs	p.K52fs	PPP2R5E_uc001xge.2_Frame_Shift_Del_p.K52fs|PPP2R5E_uc010tsh.1_Frame_Shift_Del_p.K52fs|PPP2R5E_uc001xgf.1_RNA|PPP2R5E_uc001xgg.3_Frame_Shift_Del_p.K52fs	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	52					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		GAGCCTTACCTTTTAGCAGCG	0.398			NA											30	127	---	---	---	---	NA	NA	NA	NA	NA
NRXN3	9369	broad.mit.edu	37	14	79181428	79181429	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr14:79181428_79181429insA	uc001xun.2	+	5	1362_1363	c.871_872insA	c.(871-873)CGCfs	p.R291fs	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Frame_Shift_Ins_p.R425fs	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	664	EGF-like 2.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CGGCTGGAACCGCTTCATCTGC	0.584			NA											26	85	---	---	---	---	NA	NA	NA	NA	NA
TSC2	7249	broad.mit.edu	37	16	2114374	2114374	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:2114374delG	uc002con.2	+	15	1651	c.1545delG	c.(1543-1545)CTGfs	p.L515fs	TSC2_uc010bsd.2_Frame_Shift_Del_p.L515fs|TSC2_uc002coo.2_Frame_Shift_Del_p.L515fs|TSC2_uc010uvv.1_Frame_Shift_Del_p.L478fs|TSC2_uc010uvw.1_Frame_Shift_Del_p.L466fs|TSC2_uc002cop.2_Frame_Shift_Del_p.L315fs	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	515					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				TGGTGGACCTGGCAGAGGGCT	0.602			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				93	136	---	---	---	---	NA	NA	NA	NA	NA
MAZ	4150	broad.mit.edu	37	16	29821421	29821435	+	In_Frame_Del	DEL	GCGGCGGCAGCGGCA	GCGGCGGCAGCGGCA	-	rs75194070		TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	GCGGCGGCAGCGGCA	GCGGCGGCAGCGGCA	-	-	GCGGCGGCAGCGGCA	GCGGCGGCAGCGGCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:29821421_29821435delGCGGCGGCAGCGGCA	uc002dty.2	+	5	1471_1485	c.1303_1317delGCGGCGGCAGCGGCA	c.(1303-1317)GCGGCGGCAGCGGCAdel	p.AAAAA440del	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Intron|MAZ_uc010vdx.1_In_Frame_Del_p.AAAAA417del|MAZ_uc002dtw.2_Splice_Site_p.D94_splice|MAZ_uc002dtx.2_3'UTR|MAZ_uc010bzg.2_In_Frame_Del_p.AAAAA135del|MAZ_uc002dtz.1_3'UTR|MAZ_uc002dua.2_3'UTR|MAZ_uc010vdy.1_In_Frame_Del_p.AAAAA41del|uc002duc.1_RNA|PRRT2_uc002dud.2_5'Flank|PRRT2_uc002due.3_5'Flank|PRRT2_uc002duf.1_5'Flank	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	440_444	Poly-Ala.			Missing (in Ref. 3).	regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1						TTGTCCAATggcggcggcagcggcagcggcggcag	0.474	Colon(72;875 1167 15364 30899 37091)		NA											16	89	---	---	---	---	NA	NA	NA	NA	NA
ZNF423	23090	broad.mit.edu	37	16	49672282	49672282	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr16:49672282delC	uc002efs.2	-	5	1079	c.781delG	c.(781-783)GACfs	p.D261fs	ZNF423_uc010vgn.1_Frame_Shift_Del_p.D144fs	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	261					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				ATGAAGTCGTCCTTCTTGGCT	0.607			NA											30	48	---	---	---	---	NA	NA	NA	NA	NA
YBX2	51087	broad.mit.edu	37	17	7193314	7193314	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:7193314delG	uc002gfq.2	-	6	878	c.821delC	c.(820-822)CCGfs	p.P274fs		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	274	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GAATCTGGGCGGGGGGACTCG	0.627			NA											34	101	---	---	---	---	NA	NA	NA	NA	NA
MYH8	4626	broad.mit.edu	37	17	10303967	10303967	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:10303967delC	uc002gmm.2	-	27	3570	c.3475delG	c.(3475-3477)GCAfs	p.A1159fs	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1159	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GCAGAAGTTGCCCCACCGGCT	0.607			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				62	195	---	---	---	---	NA	NA	NA	NA	NA
MYO18A	399687	broad.mit.edu	37	17	27448150	27448150	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:27448150delG	uc002hdt.1	-	6	1609	c.1451delC	c.(1450-1452)GCGfs	p.A484fs	MYO18A_uc010wbc.1_Frame_Shift_Del_p.A26fs|MYO18A_uc002hds.2_Frame_Shift_Del_p.A26fs|MYO18A_uc010csa.1_Frame_Shift_Del_p.A484fs|MYO18A_uc002hdu.1_Frame_Shift_Del_p.A484fs|MYO18A_uc010wbd.1_Frame_Shift_Del_p.A153fs	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	484	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CATCAGCATCGCCCTGTATGC	0.597	Esophageal Squamous(182;472 2015 7001 15270 22562)		NA											13	17	---	---	---	---	NA	NA	NA	NA	NA
INTS2	57508	broad.mit.edu	37	17	59946733	59946733	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr17:59946733delT	uc002izn.2	-	22	3139	c.3063delA	c.(3061-3063)CCAfs	p.P1021fs	INTS2_uc002izm.2_Frame_Shift_Del_p.P1013fs	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	1021					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						AAAGTTCACATGGATAACCCT	0.318			NA											3	6	---	---	---	---	NA	NA	NA	NA	NA
CD3EAP	10849	broad.mit.edu	37	19	45911859	45911861	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	GAA	GAA	-	-	GAA	GAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr19:45911859_45911861delGAA	uc002pbq.1	+	3	1121_1123	c.633_635delGAA	c.(631-636)CGGAAG>CGG	p.K217del	PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_In_Frame_Del_p.K219del	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	217	Poly-Lys.				rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		TGGATGTGCGGAAGAAGAAGAAG	0.581			NA											12	351	---	---	---	---	NA	NA	NA	NA	NA
HS6ST1	9394	broad.mit.edu	37	2	129026217	129026217	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr2:129026217delC	uc002tpt.3	-	2	789	c.755delG	c.(754-756)CGCfs	p.R252fs		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	252	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		GGCCAGCATGCGCACCTGGCG	0.657			NA											12	44	---	---	---	---	NA	NA	NA	NA	NA
PDZRN3	23024	broad.mit.edu	37	3	73433097	73433098	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr3:73433097_73433098insA	uc003dpl.1	-	10	2715_2716	c.2619_2620insT	c.(2617-2622)ATCCCGfs	p.I873fs	PDZRN3_uc011bgh.1_Frame_Shift_Ins_p.I530fs|PDZRN3_uc010hoe.1_Frame_Shift_Ins_p.I571fs|PDZRN3_uc011bgf.1_Frame_Shift_Ins_p.I590fs|PDZRN3_uc011bgg.1_Frame_Shift_Ins_p.I593fs	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	873_874							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCGTGCGCCGGGATGTGCGCGT	0.649			NA											18	124	---	---	---	---	NA	NA	NA	NA	NA
UGT3A1	133688	broad.mit.edu	37	5	35988559	35988560	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:35988559_35988560insA	uc003jjv.1	-	2	345_346	c.188_189insT	c.(187-189)TTGfs	p.L63fs	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Frame_Shift_Ins_p.L63fs|UGT3A1_uc011cor.1_Intron|UGT3A1_uc003jjy.1_Frame_Shift_Ins_p.L9fs	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	63	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TACCTGGGATCAAAAACTTTCC	0.327			NA											19	43	---	---	---	---	NA	NA	NA	NA	NA
SLC22A4	6583	broad.mit.edu	37	5	131676327	131676327	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:131676327delT	uc003kwq.2	+	9	1679	c.1514delT	c.(1513-1515)CTTfs	p.L505fs	uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	505	Helical; Name=12; (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ATCCTCACCCTTTTTTTCCCT	0.418			NA											9	504	---	---	---	---	NA	NA	NA	NA	NA
SPINK5	11005	broad.mit.edu	37	5	147443647	147443647	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:147443647delC	uc003lox.2	+	1	113	c.40delC	c.(40-42)CTTfs	p.L14fs	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_5'UTR|SPINK5_uc010jgr.2_Frame_Shift_Del_p.L14fs|SPINK5_uc003low.2_Frame_Shift_Del_p.L14fs|SPINK5_uc003loy.2_Frame_Shift_Del_p.L14fs	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	14					anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTTGGCTCTTTGCCTCAT	0.507			NA											19	160	---	---	---	---	NA	NA	NA	NA	NA
GPRIN1	114787	broad.mit.edu	37	5	176026665	176026665	+	Frame_Shift_Del	DEL	G	G	-	rs139277418	byFrequency	TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr5:176026665delG	uc003meo.1	-	2	346	c.171delC	c.(169-171)CCCfs	p.P57fs		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	57						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGTGTGCCTGGGGGGTGCAG	0.662			NA											44	301	---	---	---	---	NA	NA	NA	NA	NA
FTSJD2	23070	broad.mit.edu	37	6	37430722	37430722	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chr6:37430722delC	uc003ons.2	+	13	1696	c.1443delC	c.(1441-1443)GTCfs	p.V481fs		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	481					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACTTGGTGGTCCCCCTGGAGG	0.498			NA											74	168	---	---	---	---	NA	NA	NA	NA	NA
NONO	4841	broad.mit.edu	37	X	70514295	70514295	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-4112-01A-01D-1105-08	TCGA-44-4112-10A-01D-1458-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0a6af0ab-9055-4b3a-a2cd-7d8202e08701	b31338fd-60d8-48c2-ab4d-cb5064995245	g.chrX:70514295delA	uc004dzo.2	+	6	1277	c.567delA	c.(565-567)GGAfs	p.G189fs	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Frame_Shift_Del_p.G189fs|NONO_uc004dzp.2_Frame_Shift_Del_p.G189fs|NONO_uc011mpv.1_Frame_Shift_Del_p.G100fs|NONO_uc004dzq.2_Frame_Shift_Del_p.G58fs	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	189	RRM 2.|DBHS.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					GGCCCTCAGGAAAAGGCATTG	0.512			NA	T	TFE3	papillary renal cancer								25	42	---	---	---	---	NA	NA	NA	NA	NA
