Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MMEL1	79258	broad.mit.edu	37	1	2537763	2537763	+	Nonsense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:2537763G>C	uc001ajy.2	-	8	888	c.674C>G	c.(673-675)TCA>TGA	p.S225*	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	225	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GTTGAACTGTGAGTTCATCAG	0.672			NA											3	29					0	0	0.004672	0	0
H6PD	9563	broad.mit.edu	37	1	9323676	9323676	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:9323676A>T	uc001apt.2	+	5	1397	c.1124A>T	c.(1123-1125)AAC>ATC	p.N375I		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	375	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	TTGTTCAAGAACCAGGCCTGC	0.622			NA											17	46					0	0	0.004007	0	0
CASZ1	54897	broad.mit.edu	37	1	10703261	10703261	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:10703261G>A	uc001aro.2	-	19	4296	c.3976C>T	c.(3976-3978)CGG>TGG	p.R1326W		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		AGCATCCTCCGCATGTGCTTC	0.647			NA											12	43					0	0	0.016723	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854181	12854181	+	Silent	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:12854181A>G	uc001auj.1	+	3	508	c.405A>G	c.(403-405)GCA>GCG	p.A135A		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	135											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCAGACAGCAGAGGACTGTC	0.547			NA											38	165					0	0	0.006999	0	0
LOC440563	440563	broad.mit.edu	37	1	13183250	13183250	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:13183250T>C	uc010obg.1	-	1	718	c.623A>G	c.(622-624)CAG>CGG	p.Q208R		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	208						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						TTGTTTGCTCTGTTCCTTTTC	0.428			NA											9	244					0	0	0.006214	0	0
HTR1D	3352	broad.mit.edu	37	1	23520467	23520467	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:23520467G>T	uc001bgn.2	-	1	756	c.246C>A	c.(244-246)ACC>ACA	p.T82T		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	82	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	AGAGGTCGGTGGTGGCCAGGG	0.537			NA											17	87					1.01871e-10	1.4553e-10	0.008871	1	0
IL28RA	163702	broad.mit.edu	37	1	24484070	24484070	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:24484070C>A	uc001bis.2	-	7	1126	c.1113G>T	c.(1111-1113)AGG>AGT	p.R371S	IL28RA_uc001bir.2_Missense_Mutation_p.R342S|IL28RA_uc001bit.2_3'UTR|IL28RA_uc001biu.2_Missense_Mutation_p.R287S	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	371	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		CCAGAGGAGCCCTGGGCCTCC	0.627			NA											8	33					7.48243e-07	9.43437e-07	0.006214	1	0
ARID1A	8289	broad.mit.edu	37	1	27105723	27105723	+	Silent	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:27105723A>G	uc001bmv.1	+	20	5707	c.5334A>G	c.(5332-5334)GAA>GAG	p.E1778E	ARID1A_uc001bmu.1_Silent_p.E1561E|ARID1A_uc001bmx.1_Silent_p.E624E|ARID1A_uc009vsm.1_Silent_p.E106E|ARID1A_uc009vsn.1_Silent_p.E20E	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1778					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGGAAGAAGAAGAGGAAGTAG	0.468			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								6	58					0	0	0.001984	0	0
ARID1A	8289	broad.mit.edu	37	1	27106483	27106483	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:27106483G>A	uc001bmv.1	+	20	6467	c.6094G>A	c.(6094-6096)GAA>AAA	p.E2032K	ARID1A_uc001bmu.1_Missense_Mutation_p.E1815K|ARID1A_uc001bmx.1_Missense_Mutation_p.E878K|ARID1A_uc009vsm.1_Missense_Mutation_p.E360K|ARID1A_uc009vsn.1_Missense_Mutation_p.E274K	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2032					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACTAACTTATGAAAAGGAGGA	0.552			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								4	48					0	0	0.009096	0	0
ARID1A	8289	broad.mit.edu	37	1	27106495	27106495	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:27106495G>T	uc001bmv.1	+	20	6479	c.6106G>T	c.(6106-6108)GAA>TAA	p.E2036*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.E1819*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.E882*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.E364*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.E278*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2036					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AAAGGAGGAGGAACAGGACCA	0.562			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								4	52					0.00024832	0.000283515	0.009096	1	0
COL16A1	1307	broad.mit.edu	37	1	32145269	32145269	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:32145269G>T	uc001btk.1	-	42	3101	c.2736C>A	c.(2734-2736)CCC>CCA	p.P912P	COL16A1_uc001btj.1_Silent_p.P725P|COL16A1_uc001btl.3_Silent_p.P896P	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	912	Triple-helical region 4 (COL4) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTGGTGGTCCGGGAATACCTG	0.617	Colon(143;498 1786 21362 25193 36625)		NA											7	116					5.18039e-06	6.39282e-06	0.00308	1	0
CSMD2	114784	broad.mit.edu	37	1	34209109	34209109	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:34209109G>A	uc001bxn.1	-	14	1854	c.1825C>T	c.(1825-1827)CTG>TTG	p.L609L	CSMD2_uc001bxm.1_Silent_p.L649L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	609	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCCTGGCCAGGATGAGCCAG	0.587			NA											13	52					0	0	0.016723	0	0
GADD45A	1647	broad.mit.edu	37	1	68153432	68153432	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:68153432C>T	uc001ddz.1	+	4	768	c.473C>T	c.(472-474)CCA>CTA	p.P158L	GADD45A_uc009wbb.1_Missense_Mutation_p.P124L|GADD45A_uc009wbc.1_RNA|GADD45A_uc009wbd.1_RNA	NM_001924	NP_001915	P24522	GA45A_HUMAN	growth arrest and DNA-damage-inducible, alpha	158					apoptosis|cell cycle arrest|cellular response to ionizing radiation|cellular response to mechanical stimulus|DNA repair|positive regulation of reactive oxygen species metabolic process|regulation of cyclin-dependent protein kinase activity|signal transduction in response to DNA damage	nucleus	protein binding			ovary(1)	1						CAATGGGTTCCAGTGATTAAT	0.388			NA											8	77					0	0	0.00308	0	0
MSH4	4438	broad.mit.edu	37	1	76345780	76345780	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:76345780A>G	uc001dhd.1	+	13	1764	c.1723A>G	c.(1723-1725)ATT>GTT	p.I575V		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	575					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						AGCAGATTTAATTAAAATGAA	0.274			NA						MMR					11	39					0	0	0.003163	0	0
COL24A1	255631	broad.mit.edu	37	1	86581035	86581035	+	Silent	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:86581035T>C	uc001dlj.2	-	4	1560	c.1518A>G	c.(1516-1518)CCA>CCG	p.P506P	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Silent_p.P506P	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	506	Collagen-like 1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTGACGGACCTGGGATACCTG	0.418			NA											7	29					0	0	0.00308	0	0
GBP5	115362	broad.mit.edu	37	1	89735197	89735197	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:89735197G>A	uc001dnc.2	-	3	579	c.42C>T	c.(40-42)ATC>ATT	p.I14I	GBP5_uc001dnd.2_Silent_p.I14I|GBP5_uc001dne.1_Silent_p.I14I	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	14						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		TAAAGTTCTCGATGAGGCACA	0.478			NA											8	202					0	0	0.004482	0	0
TMEM56	148534	broad.mit.edu	37	1	95615767	95615767	+	Silent	SNP	T	T	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:95615767T>G	uc001drb.2	+	4	540	c.249T>G	c.(247-249)GGT>GGG	p.G83G	RWDD3_uc001drd.3_Silent_p.G83G|TMEM56_uc001drc.2_Silent_p.G83G	NM_152487	NP_689700	Q96MV1	TMM56_HUMAN	transmembrane protein 56	83	TLC.					integral to membrane					0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		TTTTCAGGGGTGGTCCATCAC	0.323			NA											5	45					0	0	0.014323	0	0
LPPR4	9890	broad.mit.edu	37	1	99771298	99771298	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:99771298G>T	uc001dse.2	+	7	1130	c.1024G>T	c.(1024-1026)GAC>TAC	p.D342Y	LPPR4_uc010oue.1_Missense_Mutation_p.D284Y	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	342							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TCAGCACAGAGACGCCCTCAG	0.448			NA											42	97					1.22674e-20	1.93345e-20	0.00874	1	0
CD101	9398	broad.mit.edu	37	1	117559956	117559957	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:117559956_117559957GG>TT	uc010oxb.1	+	5	1531_1532	c.1473_1474GG>TT	c.(1471-1476)TGGGCC>TGTTCC	p.491_492WA>CS	CD101_uc009whd.2_Missense_Mutation_p.491_492WA>CS|CD101_uc010oxc.1_Missense_Mutation_p.491_492WA>CS|CD101_uc010oxd.1_Missense_Mutation_p.429_430WA>CS	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	491_492	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						AAATGGACTGGGCCACCTTCCA	0.55			NA											20	84					0	0	0.004672	0	0
WDR3	10885	broad.mit.edu	37	1	118494942	118494942	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:118494942C>T	uc010oxe.1	+	18	1993	c.1927C>T	c.(1927-1929)CCC>TCC	p.P643S	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	643	WD 12.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		ACAGTTTGTACCCAAGTCTCA	0.363			NA											16	78					0	0	0.00499	0	0
FLG	2312	broad.mit.edu	37	1	152279939	152279939	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:152279939C>A	uc001ezu.1	-	3	7459	c.7423G>T	c.(7423-7425)GGA>TGA	p.G2475*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2475	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGTGGGATCCCTGCCTTCCT	0.582			NA							Ichthyosis				209	331					7.99439e-90	1.3401e-89	0.01441	1	0
KPRP	448834	broad.mit.edu	37	1	152732100	152732100	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:152732100G>T	uc001fal.1	+	2	94	c.36G>T	c.(34-36)CCG>CCT	p.P12P		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	12	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGCCTGCCGCTCCAACAGT	0.582			NA											37	55					1.04594e-18	1.61342e-18	0.00623	1	0
KIAA0907	22889	broad.mit.edu	37	1	155895471	155895471	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:155895471T>G	uc001fmi.1	-	7	869	c.845A>C	c.(844-846)GAG>GCG	p.E282A	KIAA0907_uc001fmj.1_Missense_Mutation_p.E282A|KIAA0907_uc009wrk.1_Intron|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.E282A|KIAA0907_uc001fmm.2_3'UTR	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	282											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			AGATGCTGGCTCAATGCAGCC	0.483			NA											5	120					0	0	0.001168	0	0
ADCY10	55811	broad.mit.edu	37	1	167787447	167787447	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:167787447G>C	uc001ger.2	-	31	4643	c.4345C>G	c.(4345-4347)CTT>GTT	p.L1449V	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.L1357V|ADCY10_uc010plj.1_Missense_Mutation_p.L1296V	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1449					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CTTGGCAAAAGATTTTTAGCT	0.373			NA											5	109					0	0	0.014758	0	0
BAT2L2	23215	broad.mit.edu	37	1	171511222	171511222	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:171511222A>T	uc010pmg.1	+	16	4877	c.4611A>T	c.(4609-4611)GAA>GAT	p.E1537D	BAT2L2_uc010pmh.1_Missense_Mutation_p.E514D	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1537							protein C-terminus binding				0						CAAAGAGGGAAATTGCAAAGA	0.418			NA											32	30					0	0	0.008361	0	0
TNR	7143	broad.mit.edu	37	1	175362997	175362997	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:175362997C>T	uc001gkp.1	-	4	1356	c.1275G>A	c.(1273-1275)ACG>ACA	p.T425T	TNR_uc009wwu.1_Silent_p.T425T|TNR_uc010pmz.1_3'UTR	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	425	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCTCTGTGATCGTCTTAAATT	0.498			NA											16	200					0	0	0.004007	0	0
FAM5B	57795	broad.mit.edu	37	1	177199216	177199216	+	Silent	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:177199216T>C	uc001glf.2	+	2	516	c.204T>C	c.(202-204)GCT>GCC	p.A68A		NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	68						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCCACCGCGCTCAGGAGTATG	0.642			NA											13	127					0	0	0.003163	0	0
CACNA1E	777	broad.mit.edu	37	1	181753820	181753820	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:181753820G>T	uc001gow.2	+	41	5659	c.5494G>T	c.(5494-5496)GAC>TAC	p.D1832Y	CACNA1E_uc009wxs.2_Missense_Mutation_p.D1720Y|CACNA1E_uc009wxt.2_Missense_Mutation_p.D1058Y	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1832	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCAGCAGCTAGACTCAGAGCT	0.483			NA											3	6					0.004672	0.00503673	0.004672	1	0
HMCN1	83872	broad.mit.edu	37	1	186056670	186056670	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:186056670G>A	uc001grq.1	+	60	9485	c.9256G>A	c.(9256-9258)GTG>ATG	p.V3086M		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3086	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTCGAACGCTGTGCCACCTCC	0.438			NA											12	176					0	0	0.010729	0	0
CACNA1S	779	broad.mit.edu	37	1	201044651	201044651	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:201044651G>A	uc001gvv.2	-	13	2147	c.1920C>T	c.(1918-1920)TAC>TAT	p.Y640Y		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	640	Helical; Name=S6 of repeat II; (Potential).|II.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GGATGATGAAGTAAATGCACA	0.542			NA											26	181					0	0	0.010818	0	0
ATP2B4	493	broad.mit.edu	37	1	203652429	203652429	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:203652429C>A	uc001gzw.2	+	2	980	c.96C>A	c.(94-96)CTC>CTA	p.L32L	ATP2B4_uc001gzv.2_Silent_p.L32L|ATP2B4_uc009xaq.2_Silent_p.L32L	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	32	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGAGGAAGCTCATGGAGCTGC	0.522			NA											73	116					3.78398e-24	6.06274e-24	0.01441	1	0
ZNF678	339500	broad.mit.edu	37	1	227843217	227843217	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:227843217C>T	uc001hqw.1	+	4	1611	c.1266C>T	c.(1264-1266)AGC>AGT	p.S422S	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	477					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				ACCTAACTAGCCATAAGAGAA	0.368			NA											5	58					0	0	0.014758	0	0
KIAA1383	54627	broad.mit.edu	37	1	232941882	232941882	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:232941882G>T	uc001hvh.2	+	1	1245	c.1113G>T	c.(1111-1113)GAG>GAT	p.E371D		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	229										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				GCCCAAAAGAGGCTGATAAGC	0.542			NA											12	149					0.00010058	0.00011857	0.013537	1	0
FMN2	56776	broad.mit.edu	37	1	240370635	240370635	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:240370635C>A	uc010pyd.1	+	5	2748	c.2523C>A	c.(2521-2523)CAC>CAA	p.H841Q	FMN2_uc010pye.1_Missense_Mutation_p.H845Q	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	841	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAACCAGCCACGAACACTCTG	0.562			NA											7	74					5.18039e-06	6.39282e-06	0.00308	1	0
OR2M3	127062	broad.mit.edu	37	1	248366864	248366864	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:248366864C>T	uc010pzg.1	+	1	495	c.495C>T	c.(493-495)TCC>TCT	p.S165S		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CAACATTTTCCTTCTCCTACT	0.438			NA											17	325					0	0	0.004007	0	0
OR2M4	26245	broad.mit.edu	37	1	248402835	248402835	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:248402835G>A	uc010pzh.1	+	1	605	c.605G>A	c.(604-606)TGT>TAT	p.C202Y		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTTGTCATTTGTTGTGTGGTA	0.438			NA											76	83					0	0	0.01441	0	0
ITGA8	8516	broad.mit.edu	37	10	15688901	15688902	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:15688901_15688902CC>AA	uc001ioc.1	-	12	1150_1151	c.1150_1151GG>TT	c.(1150-1152)GGG>TTG	p.G384L	ITGA8_uc010qcb.1_Missense_Mutation_p.G369L	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	384	Extracellular (Potential).|FG-GAP 6.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ACCGAATCTCCCAAACGTCTCG	0.48			NA											18	40					0	0	0.004672	0	0
CH25H	9023	broad.mit.edu	37	10	90966547	90966547	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:90966547G>A	uc001kfz.2	-	1	525	c.503C>T	c.(502-504)GCG>GTG	p.A168V		NM_003956	NP_003947	O95992	CH25H_HUMAN	cholesterol 25-hydroxylase	168					bile acid biosynthetic process|fatty acid biosynthetic process|sterol biosynthetic process	cytosol|endoplasmic reticulum membrane|integral to membrane	cholesterol 25-hydroxylase activity|iron ion binding				0		Colorectal(252;0.0161)		GBM - Glioblastoma multiforme(2;0.000133)		CGTTGCCAGCGCGAACGAGGA	0.577			NA											5	89					0	0	0.014758	0	0
PIPSL	266971	broad.mit.edu	37	10	95720326	95720326	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:95720326G>T	uc009xuj.2	-	1	1347	c.828C>A	c.(826-828)ATC>ATA	p.I276I		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						CTATATTATGGATTGACATCA	0.473			NA											8	67					7.48243e-07	9.43437e-07	0.006214	1	0
ENTPD7	57089	broad.mit.edu	37	10	101458381	101458381	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:101458381C>A	uc001kqa.3	+	10	1279	c.1101C>A	c.(1099-1101)AAC>AAA	p.N367K	ENTPD7_uc009xwl.2_Missense_Mutation_p.N369K	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	367	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		TGGAGAGGAACAGCCAAGTCT	0.567			NA											6	46					0.00116845	0.00128352	0.001168	1	0
SORCS3	22986	broad.mit.edu	37	10	106907469	106907469	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:106907469C>A	uc001kyi.1	+	9	1624	c.1397C>A	c.(1396-1398)ACG>AAG	p.T466K		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	466	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATCTCAGACACGCGTGGGATT	0.448	NSCLC(116;1497 1690 7108 13108 14106)		NA											10	46					4.68919e-08	6.20943e-08	0.008291	1	0
ATRNL1	26033	broad.mit.edu	37	10	116889227	116889227	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:116889227C>T	uc001lcg.2	+	5	1145	c.759C>T	c.(757-759)TGC>TGT	p.C253C	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Silent_p.C253C|ATRNL1_uc009xyq.2_Silent_p.C253C	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	253	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAGCCAATTGCGGCAGTCCAG	0.413			NA											17	43					0	0	0.004007	0	0
Unknown	0	broad.mit.edu	37	10	134660763	134660763	+	Silent	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:134660763T>A	uc010qux.1	-	34	5193	c.5193A>T	c.(5191-5193)ACA>ACT	p.T1731T		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.												NA						TGCTGGACTTTGTGGCACCCT	0.657			NA											23	61					0	0	0.01892	0	0
LSP1	4046	broad.mit.edu	37	11	1905191	1905191	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:1905191C>A	uc001lui.2	+	5	703	c.528C>A	c.(526-528)CCC>CCA	p.P176P	LSP1_uc001luj.2_Silent_p.P304P|LSP1_uc001luk.2_Silent_p.P114P|LSP1_uc001lul.2_Silent_p.P114P|LSP1_uc001lum.2_Silent_p.P114P	NM_002339	NP_002330	P33241	LSP1_HUMAN	lymphocyte-specific protein 1 isoform 1	176					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			large_intestine(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		CCAGGACACCCAGCCCCTTGG	0.572			NA											23	106					1.85244e-09	2.5221e-09	0.01892	1	0
TNNT3	7140	broad.mit.edu	37	11	1955213	1955213	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:1955213A>T	uc001luu.3	+	11	553	c.341A>T	c.(340-342)GAG>GTG	p.E114V	TNNT3_uc001lun.2_Intron|TNNT3_uc001luw.3_Missense_Mutation_p.E106V|TNNT3_uc001luo.3_Missense_Mutation_p.E106V|TNNT3_uc001lup.3_Missense_Mutation_p.E112V|TNNT3_uc001luq.3_Missense_Mutation_p.E106V|TNNT3_uc001lur.2_Missense_Mutation_p.E106V|TNNT3_uc010qxf.1_Missense_Mutation_p.E112V|TNNT3_uc010qxg.1_Missense_Mutation_p.E46V	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	125					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		GCAGAGAAGGAGAGGGAGCGC	0.652			NA											5	23					0	0	0.001168	0	0
TRIM22	10346	broad.mit.edu	37	11	5730336	5730336	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:5730336G>T	uc001mbr.2	+	8	1232	c.955G>T	c.(955-957)GAT>TAT	p.D319Y	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Missense_Mutation_p.D315Y|TRIM22_uc010qzm.1_Missense_Mutation_p.D147Y|TRIM22_uc009yeu.2_Missense_Mutation_p.D130Y|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	319	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TATTTCTGTGGATCAGAGACA	0.418	GBM(104;491 2336 5222)		NA											13	95					5.50884e-06	6.74077e-06	0.013537	1	0
PARVA	55742	broad.mit.edu	37	11	12539189	12539190	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:12539189_12539190GG>TT	uc001mki.2	+	11	949_950	c.900_901GG>TT	c.(898-903)ATGGGG>ATTTGG	p.300_301MG>IW		NM_018222	NP_060692	Q9NVD7	PARVA_HUMAN	parvin, alpha	300_301	CH 2.				cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)	3				Epithelial(150;0.00624)		TGCTGCTCATGGGGCTCCTGGA	0.614			NA											5	3					0	0	0.004672	0	0
LUZP2	338645	broad.mit.edu	37	11	25098931	25098931	+	Silent	SNP	A	A	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:25098931A>C	uc001mqs.2	+	11	1149	c.915A>C	c.(913-915)GCA>GCC	p.A305A	LUZP2_uc009yif.2_Silent_p.A219A|LUZP2_uc009yig.2_Silent_p.A263A	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	305						extracellular region				ovary(1)|skin(1)	2						ATGCCACTGCAGAAACCGAGC	0.338			NA											22	69					0	0	0.004656	0	0
ELP4	26610	broad.mit.edu	37	11	31648724	31648724	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:31648724G>C	uc001mtb.2	+	6	756	c.721G>C	c.(721-723)GAT>CAT	p.D241H	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.D241H|ELP4_uc010rdz.1_Missense_Mutation_p.D242H	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	241					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					GGAAGGATTTGATGGATCCAA	0.378			NA											3	80					0	0	0.004672	0	0
CCDC73	493860	broad.mit.edu	37	11	32636029	32636029	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:32636029T>C	uc001mtv.2	-	16	1879	c.1835A>G	c.(1834-1836)GAA>GGA	p.E612G		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	612										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TAGAGCATGTTCTCGAGTCCC	0.333			NA											11	31					0	0	0.010729	0	0
OR8H2	390151	broad.mit.edu	37	11	55872950	55872950	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:55872950C>A	uc010riy.1	+	1	432	c.432C>A	c.(430-432)CTC>CTA	p.L144L		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					GCCTCGCTCTCATCACTGGGC	0.443			NA								HNSCC(53;0.14)			7	196					1.06961e-07	1.40356e-07	0.00308	1	0
OR5T2	219464	broad.mit.edu	37	11	56000426	56000426	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:56000426A>C	uc010rjc.1	-	1	236	c.236T>G	c.(235-237)ATG>AGG	p.M79R		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	79	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TAAATTTCCCATGAGAGTGAA	0.408			NA											11	69					0	0	0.010729	0	0
CPT1A	1374	broad.mit.edu	37	11	68530172	68530172	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:68530172C>A	uc001oog.3	-	15	1968	c.1798G>T	c.(1798-1800)GGG>TGG	p.G600W	CPT1A_uc001oof.3_Missense_Mutation_p.G600W|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	600	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TCCGTCCTCCCCTCTCGGAAG	0.612			NA											11	27					0.000978159	0.00109524	0.010729	1	0
FGF4	2249	broad.mit.edu	37	11	69588893	69588893	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:69588893G>T	uc001opg.1	-	2	662	c.343C>A	c.(343-345)CTG>ATG	p.L115M	FGF4_uc010rqj.1_Intron	NM_002007	NP_001998	P08620	FGF4_HUMAN	fibroblast growth factor 4 precursor	115					cell-cell signaling|chondroblast differentiation|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade	extracellular region	growth factor activity|heparin binding				0	Melanoma(5;1.89e-05)		LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)		Pentosan Polysulfate(DB00686)	AGCTCCAGCAGGCCTGGGGGC	0.692			NA											4	8					0.00024832	0.000283515	0.009096	1	0
MOGAT2	80168	broad.mit.edu	37	11	75431194	75431194	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:75431194G>T	uc010rru.1	+	2	249	c.249G>T	c.(247-249)ATG>ATT	p.M83I	MOGAT2_uc001oww.1_Missense_Mutation_p.M83I|MOGAT2_uc010rrv.1_Missense_Mutation_p.M1I	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	83					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					GGAAGTACATGAAGGACTATT	0.602			NA											7	187					0.000157383	0.000181837	0.00308	1	0
TMEM135	65084	broad.mit.edu	37	11	87013423	87013423	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:87013423C>T	uc001pch.2	+	8	660	c.637C>T	c.(637-639)CAT>TAT	p.H213Y	TMEM135_uc010rtt.1_Missense_Mutation_p.H74Y|TMEM135_uc001pci.2_Missense_Mutation_p.H191Y	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	213						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GAGAGAGCAACATGAGGAAAA	0.383			NA											16	99					0	0	0.003163	0	0
CNTN5	53942	broad.mit.edu	37	11	100170106	100170106	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:100170106G>A	uc001pga.2	+	20	2937	c.2598G>A	c.(2596-2598)GTG>GTA	p.V866V	CNTN5_uc001pfz.2_Silent_p.V866V|CNTN5_uc001pgb.2_Silent_p.V792V|CNTN5_uc010ruk.1_Silent_p.V137V	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	866	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTCAAATTGTGGTCATCTGTT	0.328			NA											23	43					0	0	0.021523	0	0
MMP3	4314	broad.mit.edu	37	11	102709383	102709383	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:102709383G>A	uc001phj.1	-	8	1193	c.1128C>T	c.(1126-1128)ATC>ATT	p.I376I		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	376	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CTAGGGTGTGGATGCCTCTTG	0.383			NA											12	72					0	0	0.013537	0	0
C11orf88	399949	broad.mit.edu	37	11	111385678	111385678	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:111385678C>A	uc001pln.3	+	1	169	c.169C>A	c.(169-171)CGC>AGC	p.R57S	BTG4_uc001plj.2_5'Flank|BTG4_uc001plk.2_5'Flank|C11orf88_uc009yyd.2_Missense_Mutation_p.R57S|C11orf88_uc001plo.1_Missense_Mutation_p.R57S	NM_001100388	NP_001093858	Q6PI97	CK088_HUMAN	hypothetical protein LOC399949 isoform 2	57											0						GCTGGTGCTGCGCAGAGACAG	0.587			NA									OREG0021329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	45					0.00621372	0.00667399	0.006214	1	0
ALG10	84920	broad.mit.edu	37	12	34179553	34179553	+	Silent	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:34179553A>T	uc001rlm.2	+	3	1444	c.1125A>T	c.(1123-1125)CCA>CCT	p.P375P		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	375	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				TGTTAGTTCCAGCCTATATAT	0.299			NA											34	88					0	0	0.013726	0	0
NELL2	4753	broad.mit.edu	37	12	45059372	45059372	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:45059372C>A	uc001rog.2	-	13	1934	c.1339G>T	c.(1339-1341)GGG>TGG	p.G447W	NELL2_uc001rof.3_Missense_Mutation_p.G446W|NELL2_uc001roh.2_Missense_Mutation_p.G447W|NELL2_uc009zkd.2_Missense_Mutation_p.G446W|NELL2_uc010skz.1_Missense_Mutation_p.G497W|NELL2_uc010sla.1_Missense_Mutation_p.G470W|NELL2_uc001roi.1_Missense_Mutation_p.G447W|NELL2_uc010slb.1_Missense_Mutation_p.G446W|NELL2_uc001roj.2_Missense_Mutation_p.G447W	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	447	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TAATGGCGCCCTTCAGCACAC	0.418			NA											8	43					2.17888e-05	2.63281e-05	0.006214	1	0
KRT82	3888	broad.mit.edu	37	12	52797658	52797658	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:52797658C>T	uc001sai.1	-	2	562	c.447G>A	c.(445-447)GAG>GAA	p.E149E		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	149	Coil 1A.|Rod.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		TCCACTTGGTCTCCAGCAGCT	0.567			NA											4	28					0	0	0.009096	0	0
ESPL1	9700	broad.mit.edu	37	12	53663492	53663492	+	Silent	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:53663492T>C	uc001sck.2	+	3	857	c.766T>C	c.(766-768)TTG>CTG	p.L256L	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	256					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GGAGCTCACCTTGGAACACTG	0.587	Colon(53;1069 1201 2587 5382)		NA											5	93					0	0	0.014758	0	0
PDE1B	5153	broad.mit.edu	37	12	54967437	54967437	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:54967437G>T	uc001sgd.1	+	10	1174	c.1008G>T	c.(1006-1008)ATG>ATT	p.M336I	PDE1B_uc010soz.1_Missense_Mutation_p.M199I|PDE1B_uc010spa.1_Missense_Mutation_p.M295I|PDE1B_uc001sgf.2_Missense_Mutation_p.M199I|PDE1B_uc001sge.2_Missense_Mutation_p.M316I|PDE1B_uc009znq.2_Missense_Mutation_p.M132I	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	336	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCACAGACATGTCCTGCCATT	0.582			NA											19	141					4.35082e-09	5.86854e-09	0.010504	1	0
NEUROD4	58158	broad.mit.edu	37	12	55421051	55421051	+	Silent	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:55421051C>G	uc001sgp.3	+	2	1206	c.828C>G	c.(826-828)TCC>TCG	p.S276S		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	276					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						TAGAAAAATCCTACAGCTTCA	0.502			NA											31	202					0	0	0.010818	0	0
OR6C2	341416	broad.mit.edu	37	12	55846592	55846592	+	Missense_Mutation	SNP	C	C	T	rs141026850		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:55846592C>T	uc001sgz.1	+	1	595	c.595C>T	c.(595-597)CTT>TTT	p.L199F		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GATGGTTATACTTATGGCTGT	0.398			NA											13	148					0	0	0.016723	0	0
BEST3	144453	broad.mit.edu	37	12	70048953	70048953	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:70048953C>G	uc001svg.2	-	10	1968	c.1741G>C	c.(1741-1743)GAC>CAC	p.D581H	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.D368H|BEST3_uc010stm.1_Missense_Mutation_p.D475H	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	581	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TCACCAGGGTCTTCTTCACAG	0.532			NA											3	36					0	0	0.004672	0	0
CDK17	5128	broad.mit.edu	37	12	96688884	96688884	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:96688884A>G	uc001tep.1	-	10	1379	c.890T>C	c.(889-891)ATT>ACT	p.I297T	CDK17_uc009ztk.2_Missense_Mutation_p.I297T|CDK17_uc010svb.1_Missense_Mutation_p.I244T	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	297	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						ACCACGTAGAATTTGGTACAG	0.348			NA											7	62					0	0	0.001984	0	0
TDG	6996	broad.mit.edu	37	12	104373742	104373742	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:104373742C>T	uc001tkg.2	+	3	523	c.300C>T	c.(298-300)GAC>GAT	p.D100D	TDG_uc010swh.1_Silent_p.D100D|TDG_uc009zuk.2_Silent_p.D96D|TDG_uc010swi.1_5'UTR|TDG_uc010swj.1_5'UTR	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	100					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		AAATTACAGACACATTTAAAG	0.358			NA						BER_DNA_glycosylases					4	61					0	0	0.014758	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926814	130926814	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr12:130926814G>A	uc001uil.2	-	8	1196	c.1032C>T	c.(1030-1032)CTC>CTT	p.L344L	RIMBP2_uc001uim.2_Silent_p.L252L|RIMBP2_uc001uin.1_Silent_p.L3L	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	344	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCCCCAGCGTGAGGTTCATGC	0.612			NA											10	76					0	0	0.008291	0	0
FLT1	2321	broad.mit.edu	37	13	29012365	29012365	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr13:29012365A>G	uc001usb.3	-	4	791	c.506T>C	c.(505-507)TTA>TCA	p.L169S	FLT1_uc010aar.1_Missense_Mutation_p.L169S|FLT1_uc001usc.3_Missense_Mutation_p.L169S|FLT1_uc010tdp.1_Missense_Mutation_p.L169S	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	169	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TACCTTTTTTAAAGTAACAGT	0.383			NA											4	34					0	0	0.014758	0	0
DCLK1	9201	broad.mit.edu	37	13	36382450	36382450	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr13:36382450C>A	uc001uvf.2	-	14	2007	c.1774G>T	c.(1774-1776)GAT>TAT	p.D592Y	DCLK1_uc001uve.3_Missense_Mutation_p.D285Y|DCLK1_uc010teh.1_Missense_Mutation_p.D285Y|DCLK1_uc010abk.2_Missense_Mutation_p.D112Y	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	592	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TCCTGGTCATCACCACTTCTG	0.448			NA											16	53					1.01871e-10	1.4553e-10	0.008871	1	0
OR4M1	441670	broad.mit.edu	37	14	20248934	20248934	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr14:20248934G>T	uc010tku.1	+	1	453	c.453G>T	c.(451-453)GGG>GGT	p.G151G		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTGGATGGGGGGCTTCATTC	0.502			NA											105	106					2.03867e-50	3.39778e-50	0.01441	1	0
CTSG	1511	broad.mit.edu	37	14	25044575	25044575	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr14:25044575G>T	uc001wpq.2	-	2	136	c.99C>A	c.(97-99)CCC>CCA	p.P33P		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	33	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		ACGCCATGTAGGGGCGGGAGT	0.572			NA											53	66					1.19553e-41	1.98116e-41	0.01441	1	0
FSCB	84075	broad.mit.edu	37	14	44973895	44973896	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr14:44973895_44973896CC>AA	uc001wvn.2	-	1	2604_2605	c.2295_2296GG>TT	c.(2293-2298)GTGGCA>GTTTCA	p.A766S		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	766						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		GGAATTCCTGCCACCTGCGGTG	0.426			NA											43	107					0	0	0.004672	0	0
FLVCR2	55640	broad.mit.edu	37	14	76045408	76045408	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr14:76045408C>A	uc001xrs.2	+	1	469	c.93C>A	c.(91-93)CCC>CCA	p.P31P		NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	31	8 X 6 AA tandem repeats of P-S-[VS]-S- [VIAG]-[HNP].|2.				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		CGGTCCATCCCAGCGTCTCGG	0.642			NA											38	38					3.33393e-15	5.08864e-15	0.021022	1	0
DISP2	85455	broad.mit.edu	37	15	40660665	40660665	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr15:40660665C>A	uc001zlk.1	+	8	2441	c.2352C>A	c.(2350-2352)GGC>GGA	p.G784G		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	784					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TGGACACTGGCGACCCTCTGG	0.682			NA											13	58					0.000151284	0.000177621	0.016723	1	0
IQGAP1	8826	broad.mit.edu	37	15	90984897	90984897	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr15:90984897T>C	uc002bpl.1	+	8	910	c.809T>C	c.(808-810)ATG>ACG	p.M270T		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	270					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CAGGACAAAATGACAAATGCT	0.333			NA											8	41					0	0	0.00308	0	0
PCSK6	5046	broad.mit.edu	37	15	101906498	101906498	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr15:101906498T>A	uc002bwy.2	-	14	2075	c.1761A>T	c.(1759-1761)GAA>GAT	p.E587D	PCSK6_uc010bpd.2_Missense_Mutation_p.E383D|PCSK6_uc010bpe.2_Missense_Mutation_p.E587D|PCSK6_uc002bxa.2_Missense_Mutation_p.E587D|PCSK6_uc002bxb.2_Missense_Mutation_p.E587D|PCSK6_uc002bxc.1_Missense_Mutation_p.E587D|PCSK6_uc002bxd.1_Missense_Mutation_p.E587D|PCSK6_uc002bxe.2_Missense_Mutation_p.E587D|PCSK6_uc002bxf.1_Missense_Mutation_p.E87D	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	587	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGTCATGAATTCCCAGTTTG	0.537			NA											5	29					0	0	0.014758	0	0
A2BP1	54715	broad.mit.edu	37	16	7703884	7703884	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:7703884C>T	uc002cys.2	+	12	1813	c.825C>T	c.(823-825)CGC>CGT	p.R275R	A2BP1_uc010buf.1_Silent_p.R275R|A2BP1_uc002cyr.1_Silent_p.R274R|A2BP1_uc002cyt.2_Silent_p.R248R|A2BP1_uc010uxz.1_Silent_p.R318R|A2BP1_uc010uya.1_Silent_p.R232R|A2BP1_uc002cyv.1_Silent_p.R275R|A2BP1_uc010uyb.1_Silent_p.R275R|A2BP1_uc002cyw.2_Silent_p.R295R|A2BP1_uc002cyy.2_Silent_p.R295R|A2BP1_uc002cyx.2_Silent_p.R295R|A2BP1_uc010uyc.1_Silent_p.R268R	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	275					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TGCGAGGCCGCGGTCGCACCG	0.617			NA											4	29					0	0	0.009096	0	0
NPIP	9284	broad.mit.edu	37	16	15026684	15026684	+	Splice_Site	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:15026684G>C	uc002dcx.3	+	8		c.1247_splice	c.e8-1					Q9UND3	NPIP_HUMAN	Homo sapiens neuroblastoma cDNA, clone:Nbla00537, full insert sequence.						mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						CGCCTCTGCAGGGCTCAGCCC	0.642			NA											14	80					0	0	0.016723	0	0
ACSM2B	348158	broad.mit.edu	37	16	20548643	20548643	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:20548643T>G	uc002dhj.3	-	15	1881	c.1671A>C	c.(1669-1671)AAA>AAC	p.K557N	ACSM2B_uc002dhk.3_Missense_Mutation_p.K557N	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	557		ATP (By similarity).			fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TTCGTTGAATTTTCCCTGTGA	0.473			NA											65	222					0	0	0.01441	0	0
CDIPT	10423	broad.mit.edu	37	16	29874031	29874031	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:29874031C>T	uc002dum.2	-	2	454	c.54G>A	c.(52-54)CGG>CGA	p.R18R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CDIPT_uc002duk.2_5'Flank|CDIPT_uc002dul.2_5'UTR|CDIPT_uc002dun.2_Intron|LOC440356_uc010veb.1_5'Flank|LOC440356_uc002duo.2_5'Flank	NM_006319	NP_006310	O14735	CDIPT_HUMAN	CDP-diacylglycerol-inositol	18	Helical; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|phosphatidylinositol transporter activity				0						CGAAGACAATCCGGGCATAAC	0.652			NA											11	47					0	0	0.008291	0	0
ZNF720	124411	broad.mit.edu	37	16	31734594	31734594	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:31734594A>T	uc002ecn.3	+	3	350	c.146A>T	c.(145-147)AAG>ATG	p.K49M	ZNF720_uc010vfs.1_Translation_Start_Site|ZNF720_uc002eco.2_Intron|ZNF720_uc002ecp.1_Intron|ZNF720_uc002ecq.2_Missense_Mutation_p.K51M	NM_001130913	NP_001124385	Q7Z2F6	ZN720_HUMAN	zinc finger protein 720	49	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding				0						GCTGTCTCTAAGCCGGACCTG	0.468			NA											7	24					0	0	0.004482	0	0
KCTD19	146212	broad.mit.edu	37	16	67328886	67328886	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:67328886C>T	uc002esu.2	-	10	1516	c.1465G>A	c.(1465-1467)GAA>AAA	p.E489K	KCTD19_uc002est.2_Missense_Mutation_p.E261K|KCTD19_uc010vjj.1_Missense_Mutation_p.E232K	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	489						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TTGTATGCTTCACATTGTGCA	0.443			NA											14	40					0	0	0.016723	0	0
PDXDC2	283970	broad.mit.edu	37	16	70012166	70012166	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:70012166G>A	uc010vlq.1	-	5	647	c.469C>T	c.(469-471)CAA>TAA	p.Q157*	CLEC18C_uc002exy.2_Intron|PDXDC2_uc002eyb.2_RNA|PDXDC2_uc002eyc.2_Intron					SubName: Full=Putative uncharacterized protein;												0						CGCAACTCTTGCGCACGTTGA	0.453			NA											32	123					0	0	0.021022	0	0
PSMD7	5713	broad.mit.edu	37	16	74339302	74339302	+	Missense_Mutation	SNP	G	G	A	rs115842956	by1000genomes	TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:74339302G>A	uc002fcq.2	+	7	778	c.646G>A	c.(646-648)GCC>ACC	p.A216T	PSMD7_uc010vmr.1_Missense_Mutation_p.A139T	NM_002811	NP_002802	P51665	PSD7_HUMAN	proteasome 26S non-ATPase subunit 7	216				A -> G (in Ref. 1; BAA08780).	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0						GGAAAAAGTCGCCACAGGCAA	0.552			NA											13	20					0	0	0.016723	0	0
FOXL1	2300	broad.mit.edu	37	16	86613358	86613358	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr16:86613358C>A	uc002fjr.2	+	1	1244	c.1029C>A	c.(1027-1029)CAC>CAA	p.H343Q		NM_005250	NP_005241	Q12952	FOXL1_HUMAN	forkhead box L1	343					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1						CGGTACTCCACTTCCAGTAAA	0.587	NSCLC(163;308 2020 10889 11476 18208)		NA											12	28					4.3838e-07	5.60045e-07	0.016723	1	0
ZZEF1	23140	broad.mit.edu	37	17	3984731	3984731	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:3984731T>C	uc002fxe.2	-	18	2832	c.2768A>G	c.(2767-2769)AAG>AGG	p.K923R	ZZEF1_uc002fxk.1_Missense_Mutation_p.K924R	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	923							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GATGTTCATCTTGGCCAGGTC	0.498			NA											28	44					0	0	0.007291	0	0
WSCD1	23302	broad.mit.edu	37	17	6021387	6021387	+	Silent	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:6021387T>A	uc010cli.2	+	8	1633	c.1254T>A	c.(1252-1254)ATT>ATA	p.I418I	WSCD1_uc002gcn.2_Silent_p.I418I|WSCD1_uc002gco.2_Silent_p.I418I|WSCD1_uc010clj.2_Silent_p.I109I	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	418						integral to membrane	sulfotransferase activity				0						GGAGGGAGATTGAGATGTTTG	0.547			NA											13	33					0	0	0.016723	0	0
TP53	7157	broad.mit.edu	37	17	7579358	7579358	+	Missense_Mutation	SNP	C	C	A	rs11540654		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:7579358C>A	uc002gim.2	-	4	523	c.329G>T	c.(328-330)CGT>CTT	p.R110L	TP53_uc002gig.1_Missense_Mutation_p.R110L|TP53_uc002gih.2_Missense_Mutation_p.R110L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.R110L|TP53_uc010cni.1_Missense_Mutation_p.R110L|TP53_uc002gij.2_Missense_Mutation_p.R110L|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.R71L|TP53_uc010cnk.1_Missense_Mutation_p.R125L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	110	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		R -> G (in a sporadic cancer; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R110L(24)|p.R110P(8)|p.0?(7)|p.R110fs*13(5)|p.R110C(4)|p.G59fs*23(3)|p.F109_R110delFR(2)|p.R110H(2)|p.V73fs*9(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.R110fs*18(1)|p.Y107fs*44(1)|p.R110fs*39(1)|p.Y103_G112>C(1)|p.R110S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.Y103_L111>L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGCCCAGACGGAAACCGTA	0.612	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	44					1.96292e-10	2.73677e-10	0.010504	1	0
MYH3	4621	broad.mit.edu	37	17	10535949	10535949	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:10535949G>A	uc002gmq.1	-	33	4877	c.4800C>T	c.(4798-4800)AGC>AGT	p.S1600S		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1600	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CGTCCAGGGCGCTCTGCATGG	0.527			NA											7	234					0	0	0.00308	0	0
GGNBP2	79893	broad.mit.edu	37	17	34942353	34942353	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:34942353G>T	uc002hnb.2	+	11	1699	c.1450G>T	c.(1450-1452)GAT>TAT	p.D484Y	GGNBP2_uc002hna.2_3'UTR|GGNBP2_uc002hnc.1_Missense_Mutation_p.D313Y	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	484					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GGAGGGTTCGGATGTTGCCTG	0.418			NA											28	93					3.00307e-07	3.85349e-07	0.008361	1	0
ADAM11	4185	broad.mit.edu	37	17	42850753	42850753	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:42850753G>A	uc002ihh.2	+	11	950	c.950G>A	c.(949-951)CGG>CAG	p.R317Q	ADAM11_uc010wjd.1_Missense_Mutation_p.R117Q	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	317	Extracellular (Potential).|Peptidase M12B.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GTCTACCGACGGGAGGGTCTG	0.622			NA											4	49					0	0	0.014758	0	0
MSI2	124540	broad.mit.edu	37	17	55478805	55478805	+	Silent	SNP	A	A	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:55478805A>C	uc002iuz.1	+	6	551	c.378A>C	c.(376-378)GTA>GTC	p.V126V	MSI2_uc010wnm.1_Silent_p.V104V|MSI2_uc002iva.2_Silent_p.V122V	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	126	RRM 2.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		TGGAAGATGTAAAGCAATATT	0.463			NA	T	HOXA9	CML								14	82					0	0	0.004007	0	0
PPM1D	8493	broad.mit.edu	37	17	58678193	58678193	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:58678193G>T	uc002iyt.1	+	1	640	c.418G>T	c.(418-420)GCT>TCT	p.A140S	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	140	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TAAGGTTTGCGCTGCCATCCG	0.592			NA											23	37					2.89027e-11	4.17004e-11	0.014323	1	0
ABCA6	23460	broad.mit.edu	37	17	67119514	67119514	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:67119514G>A	uc002jhw.1	-	10	1477	c.1302C>T	c.(1300-1302)TTC>TTT	p.F434F		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	434					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					ATGAATTCAAGAAAAATAAAG	0.363			NA											6	32					0	0	0.001168	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128482	68128482	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:68128482G>A	uc002jin.2	+	5	740	c.254G>A	c.(253-255)TGG>TAG	p.W85*	KCNJ16_uc002jio.2_Nonsense_Mutation_p.W85*|KCNJ16_uc002jip.2_Nonsense_Mutation_p.W85*|KCNJ16_uc002jiq.2_Nonsense_Mutation_p.W117*	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	85	Helical; Name=M1; (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					ATTCTCTCGTGGTTGATATTT	0.418			NA											8	92					0	0	0.004482	0	0
GPR142	350383	broad.mit.edu	37	17	72368476	72368476	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:72368476G>A	uc010wqy.1	+	4	1126	c.1126G>A	c.(1126-1128)GTC>ATC	p.V376I	GPR142_uc010wqx.1_Missense_Mutation_p.V288I	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	376	Helical; Name=6; (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CCGGGTCTTCGTCATGCTCTA	0.662			NA											11	59					0	0	0.008291	0	0
ITGB4	3691	broad.mit.edu	37	17	73748568	73748568	+	Missense_Mutation	SNP	G	G	T	rs140930313		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:73748568G>T	uc002jpg.2	+	32	4205	c.4018G>T	c.(4018-4020)GGG>TGG	p.G1340W	ITGB4_uc002jph.2_Missense_Mutation_p.G1340W|ITGB4_uc002jpi.3_Missense_Mutation_p.G1340W|ITGB4_uc002jpj.2_Missense_Mutation_p.G1340W|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1340	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGCCCAGAGCGGGGAGGACTA	0.652			NA											9	75					0.00829132	0.00887263	0.008291	1	0
CYTH1	9267	broad.mit.edu	37	17	76705803	76705803	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:76705803G>T	uc002jvw.2	-	2	105	c.34C>A	c.(34-36)CTG>ATG	p.L12M	CYTH1_uc010wtw.1_Translation_Start_Site|CYTH1_uc010wtx.1_Translation_Start_Site	NM_017456	NP_059430	Q15438	CYH1_HUMAN	cytohesin 1 isoform 2	12	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCTGCTGTCAGGTCACTGGGA	0.473			NA											15	52					1.5739e-10	2.21568e-10	0.004007	1	0
CARD14	79092	broad.mit.edu	37	17	78176159	78176159	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:78176159G>A	uc002jxw.1	+	15	2354	c.2159G>A	c.(2158-2160)CGC>CAC	p.R720H	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.R720H|CARD14_uc010wud.1_RNA	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	720					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CATGCCCACCGCGTGAACTCT	0.637			NA											10	25					0	0	0.008291	0	0
OR7G1	125962	broad.mit.edu	37	19	9226302	9226302	+	Silent	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:9226302G>C	uc002mks.1	-	1	138	c.138C>G	c.(136-138)CTC>CTG	p.L46L		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TGACAGCCAGGAGAATGAGCA	0.488			NA											16	86					0	0	0.004007	0	0
ZNF99	7652	broad.mit.edu	37	19	22940301	22940301	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:22940301G>A	uc010xrh.1	-	5	2137	c.2137C>T	c.(2137-2139)CTT>TTT	p.L713F		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTTTTCTAAGGGTTGAGGAA	0.338			NA											5	25					0	0	0.001168	0	0
CCDC123	84902	broad.mit.edu	37	19	33370117	33370117	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:33370117C>A	uc002nty.2	-	19	2392	c.2303G>T	c.(2302-2304)GGC>GTC	p.G768V	CCDC123_uc002ntx.2_Missense_Mutation_p.G521V|CCDC123_uc010edg.2_RNA	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	768						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					GACATCGCAGCCGTCCAGCAG	0.617			NA											5	89					3.62473e-10	5.00558e-10	0.012319	1	0
CCDC123	84902	broad.mit.edu	37	19	33370119	33370119	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:33370119G>A	uc002nty.2	-	19	2390	c.2301C>T	c.(2299-2301)GAC>GAT	p.D767D	CCDC123_uc002ntx.2_Silent_p.D520D|CCDC123_uc010edg.2_RNA	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	767						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					CATCGCAGCCGTCCAGCAGGT	0.612			NA											5	94					0	0	0.012319	0	0
FFAR1	2864	broad.mit.edu	37	19	35842897	35842897	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:35842897G>A	uc002nzc.2	+	1	453	c.443G>A	c.(442-444)GGA>GAA	p.G148E		NM_005303	NP_005294	O14842	FFAR1_HUMAN	free fatty acid receptor 1	148	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GAGGCTCCAGGAGGCTGGCTG	0.682			NA											23	53					0	0	0.016522	0	0
FCGBP	8857	broad.mit.edu	37	19	40368760	40368760	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:40368760G>C	uc002omp.3	-	28	12596	c.12588C>G	c.(12586-12588)GAC>GAG	p.D4196E		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4196	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCAGTTCCAGTCATAGCTGA	0.612			NA											4	141					0	0	0.001984	0	0
PSG7	5676	broad.mit.edu	37	19	43439665	43439665	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:43439665C>A	uc002ovl.3	-	3	423	c.321G>T	c.(319-321)CTG>CTT	p.L107L	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	107	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TCTGGATCAGCAGGGATGCAT	0.423			NA											50	517					2.84144e-21	4.50282e-21	0.01441	1	0
TEX101	83639	broad.mit.edu	37	19	43920644	43920644	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:43920644G>C	uc010xwo.1	+	4	523	c.328G>C	c.(328-330)GAG>CAG	p.E110Q	TEX101_uc002owk.2_Missense_Mutation_p.E128Q	NM_001130011	NP_001123483	Q9BY14	TX101_HUMAN	testis expressed 101 isoform 2	110						anchored to membrane|plasma membrane				ovary(1)	1		Prostate(69;0.0199)				TAACTACTGTGAGGATTCCTT	0.527			NA											10	279					0	0	0.013537	0	0
ZNF226	7769	broad.mit.edu	37	19	44680542	44680542	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:44680542C>T	uc002oyp.2	+	6	1271	c.1127C>T	c.(1126-1128)TCT>TTT	p.S376F	ZNF226_uc002oyq.2_Missense_Mutation_p.S259F|ZNF226_uc002oyr.2_Missense_Mutation_p.S259F|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.S376F|ZNF226_uc002oyt.2_Missense_Mutation_p.S376F	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	376	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGTCAGGCCTCTCATCTTCAG	0.478	Pancreas(115;581 1665 13228 19278 50070)		NA											20	58					0	0	0.010504	0	0
QPCTL	54814	broad.mit.edu	37	19	46196733	46196733	+	Silent	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:46196733A>T	uc010xxr.1	+	2	491	c.270A>T	c.(268-270)CCA>CCT	p.P90P	SNRPD2_uc002pcv.2_5'Flank|SNRPD2_uc002pcw.2_5'Flank|QPCTL_uc010ekn.2_Silent_p.P90P	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	90					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		AACTGGATCCACAGCGTCTCT	0.607			NA									OREG0025560	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	92					0	0	0.006122	0	0
DMWD	1762	broad.mit.edu	37	19	46289666	46289666	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:46289666C>G	uc002pdj.1	-	3	1134	c.1088G>C	c.(1087-1089)CGA>CCA	p.R363P	DMWD_uc002pdk.1_Missense_Mutation_p.R363P|DMWD_uc010eko.1_Missense_Mutation_p.R48P	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	363	WD 3.				meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		GCCATGGCCTCGAGCCACCAC	0.667			NA											14	56					0	0	0.00499	0	0
MEIS3	56917	broad.mit.edu	37	19	47920532	47920532	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:47920532C>A	uc002pgu.2	-	2	535	c.88G>T	c.(88-90)GCA>TCA	p.A30S	MEIS3_uc002pgp.2_5'Flank|MEIS3_uc002pgq.2_Missense_Mutation_p.A111S|MEIS3_uc002pgr.2_5'UTR|MEIS3_uc002pgt.2_Missense_Mutation_p.A30S|MEIS3_uc002pgv.2_Missense_Mutation_p.A30S|MEIS3_uc002pgs.2_Missense_Mutation_p.A30S|MEIS3_uc010eld.2_Missense_Mutation_p.A30S|MEIS3_uc002pgw.2_Silent_p.P142P	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	30						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		CCTGGTACTGCGGGCACTGTC	0.652			NA											15	52					5.3912e-06	6.62478e-06	0.006122	1	0
SYT3	84258	broad.mit.edu	37	19	51133135	51133135	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:51133135G>T	uc002pst.2	-	3	1602	c.968C>A	c.(967-969)GCC>GAC	p.A323D	SYT3_uc002psv.2_Missense_Mutation_p.A323D|SYT3_uc010ycd.1_Missense_Mutation_p.A323D	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	323	C2 1.|Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GAGGTCCAGGGCCTGCAGGAT	0.607			NA											5	86					0.00116845	0.00128352	0.001168	1	0
LILRA6	79168	broad.mit.edu	37	19	54744954	54744954	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:54744954G>T	uc002qeu.1	-	5	832	c.708C>A	c.(706-708)GCC>GCA	p.A236A	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Silent_p.A236A|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Silent_p.A236A|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.A236A|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Silent_p.A236A|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Silent_p.A236A|LILRA6_uc010yeq.1_Silent_p.A236A|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Silent_p.A97A	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	236	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTGCCCAGGGGCCAGGACAG	0.642			NA											5	73					0.000602214	0.000676908	0.014758	1	0
PPP1R12C	54776	broad.mit.edu	37	19	55603623	55603623	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr19:55603623C>A	uc002qix.2	-	19	2143	c.2127G>T	c.(2125-2127)GCG>GCT	p.A709A	PPP1R12C_uc010yfs.1_Silent_p.A634A|PPP1R12C_uc002qiy.2_Silent_p.A707A	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	709	Potential.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCTTGAGCTGCGCCAGCCGCA	0.697			NA											3	7					0.004672	0.00503673	0.004672	1	0
FSHR	2492	broad.mit.edu	37	2	49247259	49247259	+	Missense_Mutation	SNP	C	C	G	rs140960768	byFrequency	TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:49247259C>G	uc002rww.2	-	3	339	c.265G>C	c.(265-267)GAT>CAT	p.D89H	FSHR_uc002rwx.2_Missense_Mutation_p.D89H|FSHR_uc010fbn.2_Missense_Mutation_p.D89H|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	89	LRR 2.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GAGAACACATCTGCCTCTATC	0.378			NA							Gonadal_Dysgenesis_46_XX				13	438					0	0	0.020292	0	0
VWA3B	200403	broad.mit.edu	37	2	98744867	98744867	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:98744867A>C	uc002syo.2	+	6	1132	c.868A>C	c.(868-870)AGC>CGC	p.S290R	VWA3B_uc010yvh.1_Missense_Mutation_p.S140R|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.2_Missense_Mutation_p.S290R|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	290										ovary(3)|large_intestine(2)|skin(1)	6						CAAGACCCACAGCAGGTAGGC	0.517			NA											12	50					0	0	0.016723	0	0
TSGA10	80705	broad.mit.edu	37	2	99636892	99636892	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:99636892C>G	uc002szg.3	-	16	2296	c.1668G>C	c.(1666-1668)CAG>CAC	p.Q556H	TSGA10_uc002szh.3_Missense_Mutation_p.Q556H|TSGA10_uc002szi.3_Missense_Mutation_p.Q556H|TSGA10_uc010fin.1_Missense_Mutation_p.Q556H	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	556	Interaction with HIF1A (By similarity).				spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						CATTTGCCATCTGACTCCTCA	0.383			NA											8	49					0	0	0.008291	0	0
TSGA10	80705	broad.mit.edu	37	2	99636894	99636894	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:99636894G>A	uc002szg.3	-	16	2294	c.1666C>T	c.(1666-1668)CAG>TAG	p.Q556*	TSGA10_uc002szh.3_Nonsense_Mutation_p.Q556*|TSGA10_uc002szi.3_Nonsense_Mutation_p.Q556*|TSGA10_uc010fin.1_Nonsense_Mutation_p.Q556*	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	556	Interaction with HIF1A (By similarity).				spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						TTTGCCATCTGACTCCTCAGG	0.383			NA											8	49					0	0	0.008291	0	0
POTEE	445582	broad.mit.edu	37	2	132021537	132021537	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:132021537C>A	uc002tsn.2	+	15	2561	c.2509C>A	c.(2509-2511)CAG>AAG	p.Q837K	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.Q437K|POTEE_uc002tsl.2_Missense_Mutation_p.Q419K|POTEE_uc010fmy.1_Missense_Mutation_p.Q301K	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	837	Actin-like.						ATP binding				0						CGTGGCCATCCAGGCCGTGCC	0.607			NA											5	167					1.33987e-11	1.95257e-11	0.008291	1	0
LRP1B	53353	broad.mit.edu	37	2	141214102	141214102	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:141214102G>T	uc002tvj.1	-	62	10857	c.9885C>A	c.(9883-9885)ACC>ACA	p.T3295T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3295	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.T3295S(1)		lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACAAGTGTGGGTTTTTCCAG	0.438	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			11	53					1.08611e-07	1.41243e-07	0.010729	1	0
PLA2R1	22925	broad.mit.edu	37	2	160832630	160832630	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:160832630G>A	uc002ube.1	-	17	2751	c.2544C>T	c.(2542-2544)CTC>CTT	p.L848L	PLA2R1_uc010zcp.1_Silent_p.L848L|PLA2R1_uc002ubf.2_Silent_p.L848L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	848	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						AATGAATTGTGAGAAGATCAC	0.403			NA											26	81					0	0	0.00632	0	0
KCNH7	90134	broad.mit.edu	37	2	163693088	163693088	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:163693088G>T	uc002uch.1	-	2	478	c.266C>A	c.(265-267)TCA>TAA	p.S89*	KCNH7_uc002uci.2_Nonsense_Mutation_p.S89*	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	89	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	CCTCTCTTCTGACCCCAGCAA	0.443	GBM(196;1492 2208 17507 24132 45496)		NA											7	35					5.4927e-09	7.34048e-09	0.004482	1	0
TTN	7273	broad.mit.edu	37	2	179445159	179445159	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:179445159T>G	uc010zfg.1	-	266	59467	c.59243A>C	c.(59242-59244)GAC>GCC	p.D19748A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D13443A|TTN_uc010zfi.1_Missense_Mutation_p.D13376A|TTN_uc010zfj.1_Missense_Mutation_p.D13251A|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20675							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGAAAGTGTCAAAGTCAGT	0.393			NA											3	94					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179641023	179641023	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:179641023C>G	uc010zfg.1	-	28	5792	c.5568G>C	c.(5566-5568)GAG>GAC	p.E1856D	TTN_uc010zfh.1_Missense_Mutation_p.E1810D|TTN_uc010zfi.1_Missense_Mutation_p.E1810D|TTN_uc010zfj.1_Missense_Mutation_p.E1810D|TTN_uc002unb.2_Missense_Mutation_p.E1856D|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1856							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTGCAGTCTCCCCTTCAA	0.483			NA											7	153					0	0	0.00308	0	0
DUSP19	142679	broad.mit.edu	37	2	183948268	183948268	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:183948268C>T	uc002upd.2	+	2	634	c.259C>T	c.(259-261)CTG>TTG	p.L87L	DUSP19_uc010frp.2_Silent_p.L87L|DUSP19_uc010zfr.1_Intron|DUSP19_uc002upe.2_Silent_p.L87L	NM_080876	NP_543152	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19 isoform 1	87					JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			ovary(4)|pancreas(1)	5						TTTGGATACACTGAAAAAGAA	0.294			NA											19	67					0	0	0.014323	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170978	207170978	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:207170978T>A	uc002vbp.2	+	5	1976	c.1726T>A	c.(1726-1728)TCG>ACG	p.S576T		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	576							nucleic acid binding|zinc ion binding			ovary(3)	3						TAACTATGGATCGAGTTGTTC	0.438			NA											3	33					0	0	0.004672	0	0
MAP2	4133	broad.mit.edu	37	2	210557723	210557723	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr2:210557723G>T	uc002vde.1	+	7	1077	c.829G>T	c.(829-831)GAG>TAG	p.E277*	MAP2_uc002vdc.1_Nonsense_Mutation_p.E277*|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Nonsense_Mutation_p.E273*	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	277			E -> D (in a colorectal cancer sample; somatic mutation).		central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity	p.E277D(1)		ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AAAAAAGGATGAGTGGGGTTT	0.458	Pancreas(27;423 979 28787 29963)		NA											8	58					0.00307968	0.00337021	0.00308	1	0
SIRPD	128646	broad.mit.edu	37	20	1517840	1517840	+	Missense_Mutation	SNP	C	C	T	rs143061754		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr20:1517840C>T	uc002wfi.2	-	3	582	c.538G>A	c.(538-540)GTC>ATC	p.V180I		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	180						extracellular region				ovary(1)|kidney(1)|skin(1)	3						CAGGGTTGGACGAAATAGTTT	0.612			NA											4	82					0	0	0.009096	0	0
CD93	22918	broad.mit.edu	37	20	23066732	23066732	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr20:23066732C>G	uc002wsv.2	-	1	246	c.98G>C	c.(97-99)GGG>GCG	p.G33A		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	33	Extracellular (Potential).|C-type lectin.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCAGGCGGTCCCCACGCAGAC	0.607			NA											7	7					0	0	0.006214	0	0
PHF20	51230	broad.mit.edu	37	20	34519298	34519298	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr20:34519298G>C	uc002xek.1	+	15	2343	c.2232G>C	c.(2230-2232)CAG>CAC	p.Q744H		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	744					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCACCCACCAGCTTCTTGGTG	0.527			NA											65	45					0	0	0.01441	0	0
BPI	671	broad.mit.edu	37	20	36965569	36965569	+	Missense_Mutation	SNP	G	G	A	rs5743549	byFrequency	TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr20:36965569G>A	uc002xib.2	+	15	1509	c.1447G>A	c.(1447-1449)GAC>AAC	p.D483N		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	483					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				GTTCGGTGCAGACGTTGTCTA	0.547			NA											19	169					0	0	0.016522	0	0
OPRL1	4987	broad.mit.edu	37	20	62729693	62729693	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr20:62729693C>A	uc002yic.2	+	5	1056	c.654C>A	c.(652-654)TGC>TGA	p.C218*	OPRL1_uc002yid.2_Nonsense_Mutation_p.C218*|OPRL1_uc002yif.3_Nonsense_Mutation_p.C213*	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	218	Helical; Name=5; (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TTGCCATCTGCATCTTCCTCT	0.622			NA											37	48					1.04352e-10	1.48343e-10	0.017118	1	0
SAMSN1	64092	broad.mit.edu	37	21	15872985	15872985	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr21:15872985C>A	uc002yju.1	-	6	715	c.633G>T	c.(631-633)GTG>GTT	p.V211V	SAMSN1_uc010gky.1_Silent_p.V43V|SAMSN1_uc002yjv.1_Silent_p.V279V	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	211	SH3.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		TGAAGTTTCCCACTTTATTGT	0.388			NA											56	120					2.93687e-30	4.81183e-30	0.01441	1	0
KCNJ6	3763	broad.mit.edu	37	21	39087237	39087237	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr21:39087237G>T	uc011aej.1	-	3	276	c.223C>A	c.(223-225)CGC>AGC	p.R75S	KCNJ6_uc002ywo.2_Missense_Mutation_p.R75S	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	75	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	GTCAGGTAGCGATAGGTCTCC	0.463	Pancreas(48;379 1118 2936 19024 28214)		NA											46	84					4.44401e-20	6.92884e-20	0.010771	1	0
KRTAP10-3	386682	broad.mit.edu	37	21	45978487	45978487	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr21:45978487C>A	uc002zfj.1	-	1	157	c.112G>T	c.(112-114)GCC>TCC	p.A38S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	38	3.|18 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						GGGGCCGGGGCGCAGCAGCTG	0.697			NA											10	27					7.07596e-05	8.47946e-05	0.006122	1	0
CSF2RB	1439	broad.mit.edu	37	22	37329941	37329941	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr22:37329941G>T	uc003aqa.3	+	10	1437	c.1220G>T	c.(1219-1221)AGG>ATG	p.R407M	CSF2RB_uc003aqc.3_Missense_Mutation_p.R413M	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	407	Extracellular (Potential).|Fibronectin type-III 2.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CCCTCCACCAGGTACTGGGCC	0.682			NA											6	25					3.59834e-05	4.32995e-05	0.001168	1	0
SMC1B	27127	broad.mit.edu	37	22	45758883	45758883	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr22:45758883G>C	uc003bgc.2	-	16	2496	c.2444C>G	c.(2443-2445)ACT>AGT	p.T815S	SMC1B_uc003bgd.2_Missense_Mutation_p.T815S	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	815	Potential.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		ATTAAGCCGAGTTTTTTGTTT	0.294			NA											3	50					0	0	0.004672	0	0
GRM7	2917	broad.mit.edu	37	3	6903372	6903372	+	Silent	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:6903372G>C	uc003bqm.2	+	1	571	c.297G>C	c.(295-297)GTG>GTC	p.V99V	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.V99V|GRM7_uc003bql.2_Silent_p.V99V	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	99	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TGCCCAACGTGACGCTGGGCG	0.597			NA											6	13					0	0	0.001984	0	0
MTMR14	64419	broad.mit.edu	37	3	9726311	9726311	+	Missense_Mutation	SNP	G	G	T	rs121434509		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:9726311G>T	uc003brz.2	+	11	1131	c.1007G>T	c.(1006-1008)CGG>CTG	p.R336L	MTMR14_uc003bsa.2_Missense_Mutation_p.R336L|MTMR14_uc003bsb.2_Missense_Mutation_p.R336L|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Missense_Mutation_p.R90L|MTMR14_uc003bsc.2_RNA	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	336			R -> Q (in a ADCNM patient; drastically reduced enzymatic activity).			perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					GGCTGGGATCGGACCCCCCTC	0.577			NA											19	48					1.55795e-14	2.35315e-14	0.012319	1	0
DCLK3	85443	broad.mit.edu	37	3	36779750	36779750	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:36779750C>A	uc003cgi.2	-	2	892	c.401G>T	c.(400-402)GGT>GTT	p.G134V		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	134						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						GATAATTTCACCCGAGGTCTT	0.572			NA											34	91					1.36615e-20	2.14153e-20	0.013726	1	0
NKTR	4820	broad.mit.edu	37	3	42674246	42674246	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:42674246C>G	uc003clo.2	+	9	851	c.704C>G	c.(703-705)TCT>TGT	p.S235C	NKTR_uc003clm.1_5'UTR|NKTR_uc003clp.2_5'UTR|NKTR_uc011azp.1_Missense_Mutation_p.S125C|NKTR_uc003clq.1_Missense_Mutation_p.S125C|NKTR_uc003clr.1_5'UTR|NKTR_uc003cls.2_5'UTR	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	235	Arg/Lys-rich (basic).|Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GTTAAACGTTCTAAAAAGAGG	0.408			NA											3	55					0	0	0.009096	0	0
ABHD5	51099	broad.mit.edu	37	3	43743969	43743969	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:43743969G>A	uc003cmx.2	+	3	506	c.396G>A	c.(394-396)GTG>GTA	p.V132V		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	132					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		ATCAGTTTGTGGAATCCATTG	0.468			NA											53	102					0	0	0.01441	0	0
LRIG1	26018	broad.mit.edu	37	3	66436675	66436675	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:66436675T>C	uc003dmx.2	-	13	1533	c.1519A>G	c.(1519-1521)ATG>GTG	p.M507V	SLC25A26_uc011bft.1_RNA|LRIG1_uc011bfu.1_Missense_Mutation_p.M127V|LRIG1_uc003dmw.2_Missense_Mutation_p.M173V|LRIG1_uc010hnz.2_Missense_Mutation_p.M223V|LRIG1_uc010hoa.2_Missense_Mutation_p.M531V	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	507	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TTGCCCACCATAGCCATGGTG	0.537			NA											6	225					0	0	0.001168	0	0
ROBO2	6092	broad.mit.edu	37	3	77629248	77629248	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:77629248G>A	uc003dpy.3	+	16	3122	c.2479G>A	c.(2479-2481)GAG>AAG	p.E827K	ROBO2_uc003dpz.2_Missense_Mutation_p.E831K|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.E831K	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	827	Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGTAAAGAGTGAGCCACAGCC	0.448			NA											14	30					0	0	0.00499	0	0
UROC1	131669	broad.mit.edu	37	3	126202291	126202291	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:126202291C>G	uc003eiz.1	-	19	1843	c.1811G>C	c.(1810-1812)GGA>GCA	p.G604A	UROC1_uc010hsi.1_Missense_Mutation_p.G664A	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	604					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		GAGGCCGAATCCCCCGTTGAT	0.607			NA											3	25					0	0	0.004672	0	0
HLTF	6596	broad.mit.edu	37	3	148760028	148760028	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:148760028G>C	uc003ewq.1	-	19	2340	c.2122C>G	c.(2122-2124)CTT>GTT	p.L708V	HLTF_uc003ewr.1_Missense_Mutation_p.L708V|HLTF_uc003ews.1_Missense_Mutation_p.L707V|HLTF_uc010hve.1_Missense_Mutation_p.L707V	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	708					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CTAAGCAAAAGACCCAGGACA	0.368			NA											3	68					0	0	0.004672	0	0
KCNAB1	7881	broad.mit.edu	37	3	156234123	156234123	+	Silent	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:156234123G>A	uc003far.2	+	11	994	c.930G>A	c.(928-930)GGG>GGA	p.G310G	KCNAB1_uc011bon.1_Silent_p.G281G|KCNAB1_uc003fas.2_Silent_p.G299G|KCNAB1_uc003fat.2_Silent_p.G292G|KCNAB1_uc010hvt.1_Silent_p.G263G|KCNAB1_uc011boo.1_Silent_p.G186G	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	310						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			ACGGAAACGGGGTGCCTGAAA	0.453			NA											8	51					0	0	0.00308	0	0
SPATA16	83893	broad.mit.edu	37	3	172835115	172835115	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:172835115C>A	uc003fin.3	-	2	565	c.407G>T	c.(406-408)CGC>CTC	p.R136L		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	136					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AAACTCATAGCGAACACCCAT	0.423			NA											5	121					1.024e-07	1.34982e-07	0.014758	1	0
KLHL6	89857	broad.mit.edu	37	3	183273319	183273319	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:183273319G>T	uc003flr.2	-	1	181	c.123C>A	c.(121-123)ATC>ATA	p.I41I	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Silent_p.I39I	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	41										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CCCCATTTAAGATCTCGACCA	0.517			NA											11	159					2.27111e-07	2.92721e-07	0.013537	1	0
FRYL	285527	broad.mit.edu	37	4	48583536	48583536	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr4:48583536C>T	uc003gyh.1	-	21	2678	c.2073G>A	c.(2071-2073)GCG>GCA	p.A691A	FRYL_uc003gyk.2_Silent_p.A691A	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	691					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GAATGACAAGCGCAAAGCCTT	0.468			NA											4	50					0	0	0.009096	0	0
PARM1	25849	broad.mit.edu	37	4	75937931	75937931	+	Missense_Mutation	SNP	G	G	A	rs34305542		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr4:75937931G>A	uc003hih.1	+	2	580	c.340G>A	c.(340-342)GGT>AGT	p.G114S		NM_015393	NP_056208	Q6UWI2	PARM1_HUMAN	prostatic androgen-repressed message-1	114	Extracellular (Potential).				positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				ovary(1)	1						GTCAACAAGCGGTGGAGTCCA	0.567			NA											30	52					0	0	0.007291	0	0
EEF1A1P9	441032	broad.mit.edu	37	4	106406047	106406047	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr4:106406047C>A	uc003hxt.1	+	1	185	c.55C>A	c.(55-57)CGT>AGT	p.R19S		NR_003586				SubName: Full=Eukaryotic translation elongation factor 1 alpha; Flags: Fragment;												0						GAAAGCTGAGCGTGAACATGG	0.443			NA											16	41					1.5739e-10	2.21568e-10	0.004007	1	0
ANK2	287	broad.mit.edu	37	4	114278606	114278606	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr4:114278606C>A	uc003ibe.3	+	38	8932	c.8832C>A	c.(8830-8832)ACC>ACA	p.T2944T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.T246T|ANK2_uc011cgb.1_Silent_p.T2959T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2911					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAAGCAAAACCCAAACAGATG	0.408			NA											72	155					5.89852e-23	9.39873e-23	0.01441	1	0
FSTL5	56884	broad.mit.edu	37	4	162577586	162577586	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr4:162577586C>T	uc003iqh.2	-	7	1224	c.788G>A	c.(787-789)GGA>GAA	p.G263E	FSTL5_uc003iqi.2_Missense_Mutation_p.G262E|FSTL5_uc010iqv.2_Missense_Mutation_p.G262E	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	263	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AGCACTTTGTCCCACAGTTGC	0.403			NA											4	52					0	0	0.001168	0	0
KIAA1712	80817	broad.mit.edu	37	4	175220304	175220304	+	Missense_Mutation	SNP	G	G	A	rs73011419	byFrequency	TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr4:175220304G>A	uc003itr.2	+	3	446	c.32G>A	c.(31-33)CGG>CAG	p.R11Q	KIAA1712_uc010iro.2_Missense_Mutation_p.R11Q|KIAA1712_uc003its.2_RNA	NM_001040157	NP_001035247	Q9C0F1	CEP44_HUMAN	HBV PreS1-transactivated protein 3 isoform a	11						centrosome|midbody|spindle pole					0		Prostate(90;0.00276)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;4.06e-18)|Epithelial(43;1.18e-15)|OV - Ovarian serous cystadenocarcinoma(60;4.65e-09)|GBM - Glioblastoma multiforme(59;0.00098)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0949)		AGAAGCTTACGGAACCTAGAA	0.373			NA											6	52					0	0	0.001984	0	0
CDH6	1004	broad.mit.edu	37	5	31299636	31299636	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:31299636C>A	uc003jhe.1	+	5	1035	c.709C>A	c.(709-711)CAA>AAA	p.Q237K	CDH6_uc003jhd.1_Missense_Mutation_p.Q237K	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	237	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AGTGGTGATTCAAGCCAAGGA	0.498			NA											27	57					1.1804e-14	1.79222e-14	0.021523	1	0
FYB	2533	broad.mit.edu	37	5	39201957	39201957	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:39201957G>A	uc003jls.2	-	1	1173	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M	FYB_uc003jlt.2_Missense_Mutation_p.T369M|FYB_uc003jlu.2_Missense_Mutation_p.T369M|FYB_uc011cpl.1_Missense_Mutation_p.T379M	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	369	Interaction with SKAP1.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			GTGGAATTTCGTCAGGTCAAC	0.458			NA											4	44					0	0	0.014758	0	0
FGF10	2255	broad.mit.edu	37	5	44388547	44388547	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:44388547T>C	uc003jog.1	-	1	238	c.238A>G	c.(238-240)AGA>GGA	p.R80G		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	80					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					AATAGCTTTCTCCAGCGGACA	0.507			NA											3	59					0	0	0.009096	0	0
ISL1	3670	broad.mit.edu	37	5	50683565	50683565	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:50683565C>A	uc003jor.2	+	3	1008	c.460C>A	c.(460-462)CGG>AGG	p.R154R		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	154					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				GCATCCAGCGCGGCCACTGCA	0.647			NA											4	19					0.00909568	0.00959181	0.009096	1	0
GZMA	3001	broad.mit.edu	37	5	54404187	54404187	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:54404187G>T	uc003jpm.2	+	4	629	c.592G>T	c.(592-594)GCT>TCT	p.A198S		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	198	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				TATGGTTTGTGCTGGAAGCCT	0.378			NA											7	67					0.000274275	0.000311921	0.004482	1	0
RAB3C	115827	broad.mit.edu	37	5	58147149	58147149	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:58147149C>T	uc003jrp.2	+	5	752	c.655C>T	c.(655-657)CCT>TCT	p.P219S		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	219					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		GGAAACTCCTCCTCCACCGCA	0.527			NA											12	29					0	0	0.010729	0	0
ELL2	22936	broad.mit.edu	37	5	95234413	95234413	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:95234413C>G	uc003klr.3	-	8	1406	c.1056G>C	c.(1054-1056)TTG>TTC	p.L352F		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	352					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TGGTGGGATTCAAATGACCAT	0.498			NA											8	189					0	0	0.004482	0	0
ZNF474	133923	broad.mit.edu	37	5	121487887	121487887	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:121487887C>A	uc003ksv.2	+	2	578	c.202C>A	c.(202-204)CTA>ATA	p.L68I		NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	68						intracellular	zinc ion binding				0		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		GACTGTGATACTATCAAAACT	0.463			NA											40	91					6.33695e-27	1.02666e-26	0.007835	1	0
CTNNA1	1495	broad.mit.edu	37	5	138118888	138118888	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:138118888A>T	uc003ldh.2	+	3	223	c.128A>T	c.(127-129)AAT>ATT	p.N43I	CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_5'UTR|CTNNA1_uc003ldi.2_5'UTR|CTNNA1_uc003ldj.2_Missense_Mutation_p.N43I	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	43	Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTAAACACCAATAGTAAAGGG	0.363			NA											15	34					0	0	0.003163	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203586	140203586	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:140203586C>A	uc003lhl.2	+	1	2226	c.2226C>A	c.(2224-2226)AGC>AGA	p.S742R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.S742R|PCDHA5_uc003lhj.1_Missense_Mutation_p.S742R	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	742	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCTCCAGCGCGGTGGGGA	0.652			NA											8	25					0.000442599	0.000501382	0.006214	1	0
PCDHA8	56140	broad.mit.edu	37	5	140220966	140220966	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:140220966C>A	uc003lhs.2	+	1	60	c.60C>A	c.(58-60)CTC>CTA	p.L20L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.L20L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	20					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding	p.L20F(1)		upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTTCTGCTCCTCGCAGCCT	0.557			NA											17	41					1.99824e-07	2.587e-07	0.00499	1	0
PCDHB11	56125	broad.mit.edu	37	5	140581504	140581504	+	Silent	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:140581504G>T	uc003liy.2	+	1	2157	c.2157G>T	c.(2155-2157)GCG>GCT	p.A719A	PCDHB11_uc011daj.1_Silent_p.A354A	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	719	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGCAGGGCGGCCTCGGTGG	0.652			NA											46	82					2.22293e-35	3.66279e-35	0.01441	1	0
PCDHB18	54660	broad.mit.edu	37	5	140615910	140615910	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:140615910A>G	uc003ljc.1	+	1	1973	c.1625A>G	c.(1624-1626)GAC>GGC	p.D542G		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						GTGGACGGCGACTCGGGCCAG	0.721			NA											13	33					0	0	0.016723	0	0
KIF4B	285643	broad.mit.edu	37	5	154394152	154394152	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:154394152G>C	uc010jih.1	+	1	893	c.733G>C	c.(733-735)GAA>CAA	p.E245Q		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	245	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGCTGGATCAGAAAGACAGAA	0.428			NA											3	78					0	0	0.004672	0	0
GABRA6	2559	broad.mit.edu	37	5	161116336	161116336	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:161116336G>C	uc003lyu.2	+	5	861	c.523G>C	c.(523-525)GGG>CGG	p.G175R	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	175	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACTCAAGTTTGGGAGCTGTAA	0.383			NA								TCGA Ovarian(5;0.080)			15	71					0	0	0.003163	0	0
CDHR2	54825	broad.mit.edu	37	5	176008567	176008567	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:176008567T>A	uc003mem.1	+	17	2108	c.2042T>A	c.(2041-2043)GTC>GAC	p.V681D	CDHR2_uc003men.1_Missense_Mutation_p.V681D	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	681	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						AAAGTCAATGTCACCATCACT	0.622			NA											4	32					0	0	0.009096	0	0
COL23A1	91522	broad.mit.edu	37	5	177715330	177715330	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:177715330A>G	uc003mje.2	-	5	794	c.436T>C	c.(436-438)TAC>CAC	p.Y146H		NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	146	Extracellular (Potential).|Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		ATTACCGGGTAGCCATCTCGT	0.418			NA											29	144					0	0	0.00632	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179301942	179301942	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr5:179301942C>T	uc003mlh.2	-	12	2183	c.2146G>A	c.(2146-2148)GGC>AGC	p.G716S	TBC1D9B_uc003mli.2_Missense_Mutation_p.G716S|TBC1D9B_uc003mlj.2_Missense_Mutation_p.G716S|TBC1D9B_uc011dgv.1_5'Flank	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	716						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGCTGCAGCCCAGCAGCTGC	0.647			NA											6	43					0	0	0.001168	0	0
SCAND3	114821	broad.mit.edu	37	6	28541214	28541214	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:28541214T>A	uc003nlo.2	-	4	3070	c.2452A>T	c.(2452-2454)AGT>TGT	p.S818C		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	818					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						cgcaaagcactaatgtttata	0			NA											50	130					0	0	0.01441	0	0
SKIV2L	6499	broad.mit.edu	37	6	31935558	31935558	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:31935558G>T	uc003nyn.1	+	22	3039	c.2650G>T	c.(2650-2652)GAC>TAC	p.D884Y	SKIV2L_uc011dou.1_Missense_Mutation_p.D726Y|SKIV2L_uc011dov.1_Missense_Mutation_p.D691Y	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	884						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CTTGTCCCAGGACCCACAGGA	0.592			NA											16	70					4.7546e-09	6.3835e-09	0.004007	1	0
TULP1	7287	broad.mit.edu	37	6	35466187	35466187	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:35466187G>T	uc003okv.3	-	15	1558	c.1546C>A	c.(1546-1548)CTA>ATA	p.L516I	TEAD3_uc003oku.3_5'Flank|TEAD3_uc010jvx.2_5'Flank|TULP1_uc003okw.3_Missense_Mutation_p.L463I	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	516					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						CGGTAGTCTAGGGTGAAGGCG	0.677	GBM(55;1027 1091 11115 23439)		NA											4	26					0.00116845	0.00128352	0.001168	1	0
GPR111	222611	broad.mit.edu	37	6	47647951	47647951	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:47647951T>A	uc010jzj.1	+	5	617	c.616T>A	c.(616-618)TGG>AGG	p.W206R	GPR111_uc010jzk.1_Missense_Mutation_p.W138R|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	206	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GCAGTCTCCCTGGATACCAGG	0.423			NA											23	100					0	0	0.004656	0	0
RHAG	6005	broad.mit.edu	37	6	49582478	49582478	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:49582478C>A	uc003ozk.3	-	5	791	c.729G>T	c.(727-729)ACG>ACT	p.T243T	RHAG_uc010jzl.2_Silent_p.T243T|RHAG_uc010jzm.2_Silent_p.T243T	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	243	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					GAGAGAAGTACGTGTTTACAA	0.537	Ovarian(176;476 2003 7720 43408 44749)		NA											15	79					1.05317e-09	1.44066e-09	0.020292	1	0
FAM83B	222584	broad.mit.edu	37	6	54805254	54805254	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:54805254G>T	uc003pck.2	+	5	1601	c.1485G>T	c.(1483-1485)TGG>TGT	p.W495C		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	495										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TACGTAACTGGAGAATTGAAT	0.408			NA											16	94					7.81268e-19	1.21159e-18	0.00499	1	0
COL19A1	1310	broad.mit.edu	37	6	70916660	70916660	+	Silent	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:70916660T>C	uc003pfc.1	+	50	3396	c.3279T>C	c.(3277-3279)AGT>AGC	p.S1093S		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1093	Triple-helical region 6 (COL6).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TGCCAGGGAGTCCAGGTCTTC	0.443			NA											9	18					0	0	0.010729	0	0
PREP	5550	broad.mit.edu	37	6	105781267	105781267	+	Missense_Mutation	SNP	C	C	A	rs144257084		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr6:105781267C>A	uc003prc.2	-	8	1140	c.937G>T	c.(937-939)GTG>TTG	p.V313L		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	313					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ATGTTGATCACGCGATAGTTG	0.443			NA											4	87					0.00909568	0.00959181	0.009096	1	0
MIOS	54468	broad.mit.edu	37	7	7629038	7629038	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:7629038A>T	uc003srf.2	+	9	2195	c.1887A>T	c.(1885-1887)TTA>TTT	p.L629F	MIOS_uc003srg.2_Missense_Mutation_p.L164F|MIOS_uc010ktq.2_Intron	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	629											0						TTTTCCAGTTAAATAGATACA	0.313			NA											30	84					0	0	0.00632	0	0
SNX13	23161	broad.mit.edu	37	7	17838743	17838743	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:17838743A>G	uc003stw.1	-	23	2579	c.2366T>C	c.(2365-2367)CTT>CCT	p.L789P	SNX13_uc003stv.2_Missense_Mutation_p.L778P|SNX13_uc010kuc.2_Missense_Mutation_p.L575P|SNX13_uc010kub.2_Missense_Mutation_p.L184P			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	789					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					ATCCATGAGAAGCAGCATTAC	0.333			NA											5	51					0	0	0.014758	0	0
GPR141	353345	broad.mit.edu	37	7	37780032	37780032	+	Missense_Mutation	SNP	G	G	T	rs141399721	by1000genomes	TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:37780032G>T	uc003tfm.1	+	1	37	c.37G>T	c.(37-39)GAT>TAT	p.D13Y	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	13	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						TTCCTCTTGCGATCCTATAGT	0.468			NA											50	246					1.19403e-26	1.92372e-26	0.01441	1	0
EPDR1	54749	broad.mit.edu	37	7	37988642	37988642	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:37988642C>G	uc003tfp.2	+	2	849	c.830C>G	c.(829-831)GCT>GGT	p.A277G	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.A96G	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	157					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						AGAAAGTCAGCTAGATCCTGT	0.463			NA											20	33					0	0	0.007413	0	0
EGFR	1956	broad.mit.edu	37	7	55249005	55249005	+	Missense_Mutation	SNP	G	G	T	rs146024686		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:55249005G>T	uc003tqk.2	+	20	2549	c.2303G>T	c.(2302-2304)AGC>ATC	p.S768I	EGFR_uc010kzg.1_Missense_Mutation_p.S723I|EGFR_uc011kco.1_Missense_Mutation_p.S715I|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	768	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S768I(53)|p.S768_V769insAWT(1)|p.S768N(1)|p.S752_V769del(1)|p.S768_V769insVAS(1)|p.S768C(1)|p.S768_V769>IL(1)|p.A767_S768insTLA(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGATGGCCAGCGTGGACAAC	0.637			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			19	78					3.28513e-13	4.86065e-13	0.021523	1	0
EGFR	1956	broad.mit.edu	37	7	55249007	55249007	+	Missense_Mutation	SNP	G	G	T	rs147149347		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:55249007G>T	uc003tqk.2	+	20	2551	c.2305G>T	c.(2305-2307)GTG>TTG	p.V769L	EGFR_uc010kzg.1_Missense_Mutation_p.V724L|EGFR_uc011kco.1_Missense_Mutation_p.V716L|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	769	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V769_D770insASV(20)|p.V769_D770insGVV(2)|p.V769M(2)|p.V769L(2)|p.V769_D770insMASVD(2)|p.V769_D770insDNV(1)|p.S768_V769insAWT(1)|p.V769_D770insCV(1)|p.S752_V769del(1)|p.V769_D770insGSV(1)|p.S768_V769insVAS(1)|p.V769_D770insGV(1)|p.S768_V769>IL(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATGGCCAGCGTGGACAACCC	0.637			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			19	77					3.28513e-13	4.86065e-13	0.021523	1	0
KCTD7	154881	broad.mit.edu	37	7	66103260	66103260	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:66103260G>A	uc003tve.2	+	3	497	c.335G>A	c.(334-336)CGC>CAC	p.R112H	RABGEF1_uc003tvf.2_5'UTR|KCTD7_uc003tvd.3_Missense_Mutation_p.R112H	NM_153033	NP_694578	Q96MP8	KCTD7_HUMAN	potassium channel tetramerisation domain	112	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)	3						AATTTCCTGCGCTCAGGGGAC	0.567			NA											7	92					0	0	0.001984	0	0
PEX1	5189	broad.mit.edu	37	7	92147358	92147358	+	Splice_Site	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:92147358T>A	uc003uly.2	-	5	569	c.473_splice	c.e5-1	p.V158_splice	PEX1_uc011khr.1_Splice_Site|PEX1_uc010ley.2_Splice_Site_p.V158_splice|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_Splice_Site	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1						microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TTAGTGCAACTGTGTAGAAAA	0.388			NA											6	37					0	0	0.001984	0	0
MUC17	140453	broad.mit.edu	37	7	100686537	100686537	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:100686537C>A	uc003uxp.1	+	3	11893	c.11840C>A	c.(11839-11841)ACC>AAC	p.T3947N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3947	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTCCTGTCACCAGTTCTACT	0.463			NA											30	90					2.70662e-09	3.66785e-09	0.009535	1	0
LAMB4	22798	broad.mit.edu	37	7	107692568	107692568	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:107692568G>T	uc010ljo.1	-	26	3974	c.3890C>A	c.(3889-3891)TCC>TAC	p.S1297Y	LAMB4_uc003vey.2_Missense_Mutation_p.S1297Y|LAMB4_uc010ljp.1_Missense_Mutation_p.S266Y	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1297	Domain II.|Potential.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AAGGACACTGGATTGCAAATC	0.378			NA											38	149					6.5261e-18	1.00136e-17	0.00874	1	0
PNPLA8	50640	broad.mit.edu	37	7	108119758	108119758	+	Silent	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:108119758T>C	uc003vff.1	-	11	2351	c.1944A>G	c.(1942-1944)CCA>CCG	p.P648P	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Silent_p.P648P|PNPLA8_uc003vfi.1_Silent_p.P548P|PNPLA8_uc003vfj.1_Silent_p.P648P|PNPLA8_uc003vfk.1_Silent_p.P548P	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	648					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						ACGGCACATCTGGCCAAAGAC	0.393			NA											24	61					0	0	0.01892	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117400700	117400700	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:117400700A>C	uc003vjf.2	-	10	3053	c.2961T>G	c.(2959-2961)GAT>GAG	p.D987E		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	987										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ATTCCAAGTCATCAGAACCAT	0.348			NA											30	134					0	0	0.008361	0	0
CPA4	51200	broad.mit.edu	37	7	129939236	129939236	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:129939236G>T	uc003vpr.2	+	3	324	c.277G>T	c.(277-279)GAC>TAC	p.D93Y	CPA4_uc011kpd.1_Missense_Mutation_p.D93Y|CPA4_uc011kpe.1_Intron	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	93					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GACAATTGAGGACCTGCAGGT	0.522			NA											13	46					4.36969e-10	6.00574e-10	0.016723	1	0
EXOC4	60412	broad.mit.edu	37	7	133622733	133622733	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:133622733A>T	uc003vrk.2	+	14	2152	c.2117A>T	c.(2116-2118)GAC>GTC	p.D706V	EXOC4_uc011kpo.1_Missense_Mutation_p.D605V|EXOC4_uc003vrl.2_Missense_Mutation_p.D316V|EXOC4_uc011kpp.1_Missense_Mutation_p.D238V|EXOC4_uc011kpq.1_5'UTR	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	706					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GACGTCAGTGACCTCAAAGCC	0.453			NA											30	73					0	0	0.008361	0	0
MGAM	8972	broad.mit.edu	37	7	141730170	141730170	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:141730170G>T	uc003vwy.2	+	11	1284	c.1230G>T	c.(1228-1230)CAG>CAT	p.Q410H		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	410	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGGATGTTCAGCATGCTGATA	0.328			NA											7	31					0.000157383	0.000181837	0.00308	1	0
TRY6	154754	broad.mit.edu	37	7	142480063	142480063	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:142480063C>A	uc011ksq.1	+	2	278	c.195C>A	c.(193-195)TAC>TAA	p.Y65*	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_RNA|uc003wan.1_Intron|TRY6_uc011kso.1_RNA|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						GTCACTGCTACAAGCCGTAAG	0.567			NA											5	42					0.000157383	0.000181837	0.00308	1	0
Unknown	0	broad.mit.edu	37	7	142510501	142510501	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:142510501C>A	uc003wbp.2	-	2	217	c.105G>T	c.(103-105)CCG>CCT	p.P35P						SubName: Full=V_segment translation product; Flags: Fragment;												NA						CCAGAGAGAGCGGGCTGCCCA	0.572			NA											5	12					0.00116845	0.00128352	0.001168	1	0
ASB10	136371	broad.mit.edu	37	7	150884096	150884096	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:150884096G>C	uc003wjm.1	-	1	383	c.257C>G	c.(256-258)TCT>TGT	p.S86C	ASB10_uc003wjl.1_Missense_Mutation_p.S86C|ASB10_uc003wjn.1_Intron	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	41					intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCCGGGCCAGACTTGAGGTG	0.662			NA											6	14					0	0	0.001168	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926709	157926709	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:157926709G>A	uc003wno.2	-	9	1337	c.1216C>T	c.(1216-1218)CAC>TAC	p.H406Y	PTPRN2_uc003wnp.2_Missense_Mutation_p.H389Y|PTPRN2_uc003wnq.2_Missense_Mutation_p.H406Y|PTPRN2_uc003wnr.2_Missense_Mutation_p.H368Y|PTPRN2_uc011kwa.1_Missense_Mutation_p.H429Y	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	406	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CGAGACCCGTGGTCCTGCAGG	0.582			NA											13	42					0	0	0.020292	0	0
UNC5D	137970	broad.mit.edu	37	8	35624454	35624454	+	Missense_Mutation	SNP	G	G	A	rs112851152		TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:35624454G>A	uc003xjr.1	+	15	2676	c.2348G>A	c.(2347-2349)CGG>CAG	p.R783Q	UNC5D_uc003xjs.1_Missense_Mutation_p.R778Q|UNC5D_uc003xju.1_Missense_Mutation_p.R359Q	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	783	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGCAGTAACCGGCAGCCCCTG	0.587			NA											5	52					0	0	0.001168	0	0
ADAM18	8749	broad.mit.edu	37	8	39537627	39537627	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:39537627C>A	uc003xni.2	+	16	1703	c.1703C>A	c.(1702-1704)ACA>AAA	p.T568K	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.T544K	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	568	Cys-rich.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			GCTCAATCTACAGTTTATTCA	0.398			NA											12	98					1.36491e-13	2.04033e-13	0.016723	1	0
ADAM2	2515	broad.mit.edu	37	8	39679167	39679167	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:39679167G>T	uc003xnj.2	-	5	357	c.282C>A	c.(280-282)TAC>TAA	p.Y94*	ADAM2_uc003xnk.2_Nonsense_Mutation_p.Y94*|ADAM2_uc011lck.1_Nonsense_Mutation_p.Y94*|ADAM2_uc003xnl.2_Nonsense_Mutation_p.Y94*	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	94					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TATACCCTTGGTAGTGGCAGA	0.299			NA											3	74					0.00024832	0.000283515	0.009096	1	0
ANK1	286	broad.mit.edu	37	8	41572528	41572528	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:41572528A>T	uc003xok.2	-	15	1751	c.1667T>A	c.(1666-1668)CTG>CAG	p.L556Q	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.L556Q|ANK1_uc003xoj.2_Missense_Mutation_p.L556Q|ANK1_uc003xol.2_Missense_Mutation_p.L556Q|ANK1_uc003xom.2_Missense_Mutation_p.L589Q	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	556	89 kDa domain.|ANK 16.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTCCCGCTCCAGCAGCAGCTC	0.607			NA											7	71					0	0	0.00308	0	0
PREX2	80243	broad.mit.edu	37	8	68965476	68965476	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:68965476G>A	uc003xxv.1	+	9	1115	c.1088G>A	c.(1087-1089)CGG>CAG	p.R363Q	PREX2_uc003xxu.1_Missense_Mutation_p.R363Q|PREX2_uc011lez.1_Missense_Mutation_p.R298Q	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	363					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AGAGAACGGCGGAAAGGTGGG	0.373			NA											11	134					0	0	0.010729	0	0
CSMD3	114788	broad.mit.edu	37	8	113323246	113323246	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:113323246C>A	uc003ynu.2	-	50	8005	c.7846G>T	c.(7846-7848)GGG>TGG	p.G2616W	CSMD3_uc003yns.2_Missense_Mutation_p.G1818W|CSMD3_uc003ynt.2_Missense_Mutation_p.G2576W|CSMD3_uc011lhx.1_Missense_Mutation_p.G2512W|CSMD3_uc003ynw.1_Missense_Mutation_p.G327W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2616	Extracellular (Potential).|Sushi 14.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GCATGATACCCATAGGAAGAC	0.468			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			48	58					3.10996e-30	5.06679e-30	0.01441	1	0
CSMD3	114788	broad.mit.edu	37	8	113563023	113563023	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:113563023G>T	uc003ynu.2	-	27	4600	c.4441C>A	c.(4441-4443)CTT>ATT	p.L1481I	CSMD3_uc003yns.2_Missense_Mutation_p.L753I|CSMD3_uc003ynt.2_Missense_Mutation_p.L1441I|CSMD3_uc011lhx.1_Missense_Mutation_p.L1377I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1481	Extracellular (Potential).|CUB 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCTTTAAAAGCATATCATTT	0.388			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	106					0.000157383	0.000181837	0.00308	1	0
COL22A1	169044	broad.mit.edu	37	8	139611019	139611019	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:139611019C>T	uc003yvd.2	-	61	4755	c.4308G>A	c.(4306-4308)GAG>GAA	p.E1436E	COL22A1_uc011ljo.1_Silent_p.E716E	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1436	Pro-rich.|Gly-rich.|Collagen-like 14.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGGTCCATTCTCCCCAGGTA	0.622			NA								HNSCC(7;0.00092)			41	54					0	0	0.007835	0	0
TSNARE1	203062	broad.mit.edu	37	8	143427140	143427140	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:143427140C>A	uc003ywk.2	-	3	320	c.202G>T	c.(202-204)GCA>TCA	p.A68S	TSNARE1_uc011lju.1_Missense_Mutation_p.A68S|TSNARE1_uc003ywj.2_Missense_Mutation_p.A68S|TSNARE1_uc003ywl.3_Intron	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	68					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGCGTGCCTGCTGGCCCCAGA	0.622			NA											16	23					1.3612e-06	1.7015e-06	0.003163	1	0
ZC3H3	23144	broad.mit.edu	37	8	144621188	144621188	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr8:144621188G>C	uc003yyd.2	-	2	378	c.349C>G	c.(349-351)CTC>GTC	p.L117V		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	117					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CCCTGACTGAGCTGGACCTGT	0.622			NA											5	124					0	0	0.014758	0	0
KIAA1432	57589	broad.mit.edu	37	9	5765728	5765728	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:5765728G>A	uc003zji.2	+	20	2923	c.2830G>A	c.(2830-2832)GAA>AAA	p.E944K	KIAA1432_uc003zjh.2_Missense_Mutation_p.E944K|KIAA1432_uc003zjl.3_Missense_Mutation_p.E907K|KIAA1432_uc003zjj.1_Missense_Mutation_p.E486K|ERMP1_uc011lme.1_RNA	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1023						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCAGTCAGCTGAAAATGTTCC	0.398			NA											11	172					0	0	0.00499	0	0
FAM75A3	727830	broad.mit.edu	37	9	40702749	40702749	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:40702749C>A	uc010mmj.2	+	4	435	c.406C>A	c.(406-408)CAG>AAG	p.Q136K		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	136	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGGAGCCTCCCAGTCCTCTCA	0.602			NA											9	211					0.00010058	0.00011857	0.013537	1	0
Unknown	0	broad.mit.edu	37	9	90744703	90744703	+	Silent	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:90744703C>T	uc011lti.1	-	4	3278	c.3249G>A	c.(3247-3249)CAG>CAA	p.Q1083Q	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;												NA						CTTGAAACTGCTGTCTTTGCT	0.522			NA											12	77					0	0	0.003163	0	0
SMC2	10592	broad.mit.edu	37	9	106901541	106901541	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:106901541C>T	uc004bbv.2	+	25	3827	c.3539C>T	c.(3538-3540)TCA>TTA	p.S1180L	SMC2_uc004bbw.2_Missense_Mutation_p.S1180L|SMC2_uc011lvl.1_Missense_Mutation_p.S1180L|SMC2_uc004bbx.2_Missense_Mutation_p.S1180L|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1180					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						GGAAAGATTTCAAAGGAAGCA	0.348			NA											7	42					0	0	0.00308	0	0
TLR4	7099	broad.mit.edu	37	9	120474988	120474988	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:120474988C>G	uc004bjz.2	+	3	873	c.582C>G	c.(580-582)GAC>GAG	p.D194E	TLR4_uc004bka.2_Missense_Mutation_p.D154E|TLR4_uc004bkb.2_5'UTR	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	194	Extracellular (Potential).|LRR 6.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ATTGCACAGACTTGCGGGTTC	0.388			NA											21	62					0	0	0.014323	0	0
OR1J2	26740	broad.mit.edu	37	9	125273566	125273566	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:125273566C>A	uc004bmj.1	+	4	1341	c.486C>A	c.(484-486)CTC>CTA	p.L162L	OR1J2_uc011lyv.1_Silent_p.L162L	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						ACACCCTTCTCCTGACCCGGC	0.527			NA											27	95					2.48779e-11	3.6073e-11	0.005443	1	0
ZNF79	7633	broad.mit.edu	37	9	130198191	130198191	+	Silent	SNP	T	T	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:130198191T>G	uc004bqw.3	+	4	651	c.237T>G	c.(235-237)CTT>CTG	p.L79L	ZNF79_uc011maf.1_Silent_p.L55L|ZNF79_uc011mag.1_Silent_p.L55L	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						GAATAGGACTTCCAGTTTCCC	0.507			NA											13	97					0	0	0.00499	0	0
CIZ1	25792	broad.mit.edu	37	9	130942800	130942800	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:130942800G>A	uc004btt.2	-	7	848	c.685C>T	c.(685-687)CAA>TAA	p.Q229*	CIZ1_uc004btr.2_Nonsense_Mutation_p.Q229*|CIZ1_uc004bts.2_Nonsense_Mutation_p.Q200*|CIZ1_uc011maq.1_Nonsense_Mutation_p.Q224*|CIZ1_uc004btu.2_Nonsense_Mutation_p.Q205*|CIZ1_uc011mar.1_Nonsense_Mutation_p.Q128*|CIZ1_uc011mas.1_Nonsense_Mutation_p.Q259*|CIZ1_uc004btw.2_Nonsense_Mutation_p.Q229*|CIZ1_uc004btv.2_Nonsense_Mutation_p.Q229*|CIZ1_uc004btx.2_Nonsense_Mutation_p.Q205*	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	229						nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						GGTAAATCTTGGTCTGGAATG	0.582			NA											3	69					0	0	0.009096	0	0
SETX	23064	broad.mit.edu	37	9	135224674	135224674	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:135224674G>T	uc004cbk.2	-	3	325	c.142C>A	c.(142-144)CAC>AAC	p.H48N		NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	48					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CTTGCTTTGTGGTACTCAGCC	0.438			NA											15	48					7.93312e-07	9.95933e-07	0.020292	1	0
TUBBP5	643224	broad.mit.edu	37	9	141071154	141071154	+	Missense_Mutation	SNP	T	T	C	rs150819761	by1000genomes	TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr9:141071154T>C	uc004com.2	+	4	818	c.557T>C	c.(556-558)GTC>GCC	p.V186A	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						GTGAACATGGTCCCGTTTCCC	0.632			NA											8	43					0	0	0.008291	0	0
FRMPD4	9758	broad.mit.edu	37	X	12735649	12735649	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:12735649G>C	uc004cuz.1	+	16	3210	c.2704G>C	c.(2704-2706)GAG>CAG	p.E902Q	FRMPD4_uc011mij.1_Missense_Mutation_p.E894Q	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	902					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TTATAGTCCTGAGTCTTCGTC	0.453			NA											4	119					0	0	0.009096	0	0
GPR64	10149	broad.mit.edu	37	X	19031921	19031921	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:19031921G>T	uc004cyx.2	-	16	1146	c.982C>A	c.(982-984)CCT>ACT	p.P328T	GPR64_uc004cyy.2_Missense_Mutation_p.P325T|GPR64_uc004cyz.2_Missense_Mutation_p.P314T|GPR64_uc004czb.2_Missense_Mutation_p.P328T|GPR64_uc004czc.2_Missense_Mutation_p.P312T|GPR64_uc004czd.2_Missense_Mutation_p.P304T|GPR64_uc004cze.2_Missense_Mutation_p.P298T|GPR64_uc004czf.2_Missense_Mutation_p.P290T|GPR64_uc004cza.2_Missense_Mutation_p.P306T|GPR64_uc004cyw.2_Missense_Mutation_p.P312T|GPR64_uc010nfj.2_Missense_Mutation_p.P298T	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	328	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TGGGGCATAGGGGAAGAGATC	0.572			NA											6	127					8.12818e-05	9.66055e-05	0.001984	1	0
USP9X	8239	broad.mit.edu	37	X	41029762	41029762	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:41029762C>T	uc004dfb.2	+	20	3550	c.2917C>T	c.(2917-2919)CCT>TCT	p.P973S	USP9X_uc004dfc.2_Missense_Mutation_p.P973S	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	973					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTCCAATATGCCTTCAAGCCC	0.363	Ovarian(172;1807 2695 35459 49286)		NA											4	66					0	0	0.014758	0	0
ITIH5L	347365	broad.mit.edu	37	X	54783839	54783839	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:54783839G>T	uc004dtj.2	-	8	2698	c.2668C>A	c.(2668-2670)CCT>ACT	p.P890T		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	890	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GGTCTGTCAGGTCTAGGAGGT	0.522			NA											20	69					1.15919e-05	1.41245e-05	0.008871	1	0
VSIG4	11326	broad.mit.edu	37	X	65252505	65252505	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:65252505C>A	uc004dwh.2	-	3	626	c.499G>T	c.(499-501)GCT>TCT	p.A167S	VSIG4_uc004dwi.2_Intron|VSIG4_uc010nkq.1_Missense_Mutation_p.A167S|VSIG4_uc004dwj.2_Missense_Mutation_p.A167S|VSIG4_uc011moy.1_Intron|VSIG4_uc004dwk.2_Missense_Mutation_p.A167S|VSIG4_uc004dwl.2_Missense_Mutation_p.A63S	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	167	Ig-like 2.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						GAACCCCGAGCCTGGCATTGA	0.488			NA											3	37					0.004672	0.00503673	0.004672	1	0
ATRX	546	broad.mit.edu	37	X	76875878	76875878	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:76875878T>C	uc004ecp.3	-	20	5489	c.5257A>G	c.(5257-5259)AAT>GAT	p.N1753D	ATRX_uc004ecq.3_Missense_Mutation_p.N1715D|ATRX_uc004eco.3_Missense_Mutation_p.N1538D	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1753	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATTAGGTTATTTTGAAGTGGT	0.318			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						24	43					0	0	0.00632	0	0
TAF9B	51616	broad.mit.edu	37	X	77395088	77395088	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:77395088C>A	uc004eda.2	-	1	92	c.21G>T	c.(19-21)GCG>GCT	p.A7A		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	7					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						TCTTGGGAGGCGCCATCTTGC	0.657			NA											5	88					0.000602214	0.000676908	0.014758	1	0
POF1B	79983	broad.mit.edu	37	X	84600895	84600895	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:84600895G>T	uc004eer.2	-	6	840	c.694C>A	c.(694-696)CAT>AAT	p.H232N	POF1B_uc004ees.2_Missense_Mutation_p.H232N	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	232							actin binding				0						GATCCACTATGGCACAGTTCA	0.408			NA											9	127					1.11149e-13	1.67012e-13	0.008291	1	0
PCDH11X	27328	broad.mit.edu	37	X	91090841	91090841	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:91090841C>A	uc004efk.1	+	1	1183	c.338C>A	c.(337-339)GCC>GAC	p.A113D	PCDH11X_uc004efl.1_Missense_Mutation_p.A113D|PCDH11X_uc004efo.1_Missense_Mutation_p.A113D|PCDH11X_uc010nmv.1_Missense_Mutation_p.A113D|PCDH11X_uc004efm.1_Missense_Mutation_p.A113D|PCDH11X_uc004efn.1_Missense_Mutation_p.A113D|PCDH11X_uc004efh.1_Missense_Mutation_p.A113D|PCDH11X_uc004efj.1_Missense_Mutation_p.A113D	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	113	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GTGGAGGTTGCCATTTTGCCG	0.398	NSCLC(38;925 1092 2571 38200 45895)		NA											23	98					2.81731e-10	3.90919e-10	0.010818	1	0
PCDH19	57526	broad.mit.edu	37	X	99663168	99663168	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:99663168C>A	uc010nmz.2	-	1	2104	c.428G>T	c.(427-429)AGC>ATC	p.S143I	PCDH19_uc004efw.3_Missense_Mutation_p.S143I|PCDH19_uc004efx.3_Missense_Mutation_p.S143I	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	143	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CGTGCCAGGGCTGGCTGCCTC	0.592			NA											5	78					8.12818e-05	9.66055e-05	0.001984	1	0
SYTL4	94121	broad.mit.edu	37	X	99955913	99955913	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:99955913C>G	uc004egd.3	-	7	875	c.519G>C	c.(517-519)CAG>CAC	p.Q173H	SYTL4_uc010nnc.2_Missense_Mutation_p.Q173H|SYTL4_uc004ege.3_Missense_Mutation_p.Q173H|SYTL4_uc004egf.3_Missense_Mutation_p.Q173H|SYTL4_uc004egg.3_Missense_Mutation_p.Q173H	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	173					exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTGCCGCTCCTGAATGATCT	0.378			NA											8	137					0	0	0.004482	0	0
NGFRAP1	27018	broad.mit.edu	37	X	102632569	102632569	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:102632569C>A	uc004eki.2	+	3	532	c.150C>A	c.(148-150)GCC>GCA	p.A50A	NGFRAP1_uc004ekh.2_Silent_p.A40A|NGFRAP1_uc004ekj.1_Silent_p.A50A	NM_206915	NP_996798	Q00994	BEX3_HUMAN	nerve growth factor receptor (TNFRSF16)	50					apoptosis|multicellular organismal development|nerve growth factor receptor signaling pathway	cytosol|nucleus	caspase regulator activity|metal ion binding				0						TTCGATGGGCCATACCCAATA	0.517			NA											10	215					3.07112e-06	3.82242e-06	0.010729	1	0
ESX1	80712	broad.mit.edu	37	X	103495442	103495442	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:103495442C>T	uc004ely.2	-	4	746	c.688G>A	c.(688-690)GAT>AAT	p.D230N		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	230					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAAGCAGGATCCAGAGCAGGA	0.413	Pancreas(200;1705 2227 25194 28471 45274)		NA											11	124					0	0	0.010729	0	0
IRS4	8471	broad.mit.edu	37	X	107978288	107978288	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:107978288C>A	uc004eoc.2	-	1	1320	c.1287G>T	c.(1285-1287)CCG>CCT	p.P429P		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	429						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						AAAAGCTGGCCGGCACTGAAA	0.637			NA											10	70					1.76689e-08	2.35045e-08	0.006214	1	0
LUZP4	51213	broad.mit.edu	37	X	114536683	114536683	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:114536683G>A	uc004eqa.2	+	2	252	c.218G>A	c.(217-219)CGG>CAG	p.R73Q	LUZP4_uc004eqb.2_Missense_Mutation_p.G31R	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	73						nucleus				ovary(2)	2						CATCGCCATCGGAGAGGTAAA	0.348			NA											19	152					0	0	0.008871	0	0
VGLL1	51442	broad.mit.edu	37	X	135631167	135631167	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:135631167T>A	uc004ezy.2	+	3	804	c.634T>A	c.(634-636)TAT>AAT	p.Y212N	MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					CTCAGTTCACTGTAAGGAAAT	0.547			NA											5	47					0	0	0.001168	0	0
CXorf66	347487	broad.mit.edu	37	X	139038879	139038879	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:139038879C>A	uc004fbb.2	-	3	284	c.262G>T	c.(262-264)GCA>TCA	p.A88S		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	88	Cytoplasmic (Potential).					integral to membrane					0						GACTTGGCTGCTATGCCTTTT	0.388			NA											5	128					5.9392e-07	7.55425e-07	0.001168	1	0
GABRQ	55879	broad.mit.edu	37	X	151821552	151821552	+	Silent	SNP	C	C	A			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chrX:151821552C>A	uc004ffp.1	+	9	1727	c.1707C>A	c.(1705-1707)GGC>GGA	p.G569G		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	569						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGGCCCATGGCCAAGAGAAGG	0.498			NA											6	48					0.00116845	0.00128352	0.001168	1	0
HMCN1	83872	broad.mit.edu	37	1	186106738	186106739	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr1:186106738_186106739insT	uc001grq.1	+	88	13920_13921	c.13691_13692insT	c.(13690-13692)GGTfs	p.G4564fs	HMCN1_uc001grs.1_Frame_Shift_Ins_p.G133fs	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4564	TSP type-1 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCAGCCAATGGTGGGAAGCCCT	0.485			NA											8	52	---	---	---	---	NA	NA	NA	NA	NA
DNA2	1763	broad.mit.edu	37	10	70191626	70191644	+	Frame_Shift_Del	DEL	CATATCGTAGTTGTTTTTC	CATATCGTAGTTGTTTTTC	-	rs61855090	by1000genomes	TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	CATATCGTAGTTGTTTTTC	CATATCGTAGTTGTTTTTC	-	-	CATATCGTAGTTGTTTTTC	CATATCGTAGTTGTTTTTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr10:70191626_70191644delCATATCGTAGTTGTTTTTC	uc001jof.2	-	13	2216_2234	c.2216_2234delGAAAAACAACTACGATATG	c.(2215-2235)GGAAAAACAACTACGATATGTfs	p.G739fs	DNA2_uc001jog.1_Frame_Shift_Del_p.G653fs|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	653_659					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						TACGAGAGTACATATCGTAGTTGTTTTTCCTGTCCCAGG	0.37			NA											10	166	---	---	---	---	NA	NA	NA	NA	NA
MUC6	4588	broad.mit.edu	37	11	1027368	1027368	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr11:1027368delG	uc001lsw.2	-	17	2182	c.2131delC	c.(2131-2133)CAAfs	p.Q711fs		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	711					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCGCCCTTTTGGTTCAGGTAG	0.632			NA											42	126	---	---	---	---	NA	NA	NA	NA	NA
CWC25	54883	broad.mit.edu	37	17	36981429	36981429	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr17:36981429delC	uc002hqu.2	-	1	161	c.8delG	c.(7-9)GGCfs	p.G3fs	CWC25_uc010wdv.1_5'UTR|CWC25_uc010wdx.1_Intron	NM_017748	NP_060218	Q9NXE8	CWC25_HUMAN	coiled-coil domain containing 49	3											0						CAGGTCTCCGCCCCCCATGAC	0.607			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
GALNTL2	117248	broad.mit.edu	37	3	16250019	16250019	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr3:16250019delG	uc003car.3	+	4	1396	c.921delG	c.(919-921)GTGfs	p.V307fs	GALNTL2_uc003caq.3_Frame_Shift_Del_p.V40fs	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	307	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GGAGCCGAGTGGTATCTCCGG	0.433			NA											13	259	---	---	---	---	NA	NA	NA	NA	NA
TRRAP	8295	broad.mit.edu	37	7	98498314	98498314	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-6147-01A-11D-1753-08	TCGA-44-6147-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7b6daa70-492e-4283-b3d2-b26f4e26a8d4	3ca8208a-ca5b-45e8-968d-9f47b6201fd1	g.chr7:98498314delT	uc003upp.2	+	11	1077	c.868delT	c.(868-870)TTTfs	p.F290fs	TRRAP_uc011kis.1_Frame_Shift_Del_p.F290fs|TRRAP_uc003upr.2_5'UTR	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	290					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AACATTGTCATTTTTAGCTTA	0.254			NA											36	139	---	---	---	---	NA	NA	NA	NA	NA
