Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNFRSF18	8784	broad.mit.edu	37	1	1139804	1139804	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:1139804C>T	uc001adc.2	-	3	511	c.373G>A	c.(373-375)GAA>AAA	p.E125K	TNFRSF18_uc001ada.2_Missense_Mutation_p.E53K|TNFRSF18_uc001adb.2_Missense_Mutation_p.E125K|TNFRSF18_uc001add.2_Missense_Mutation_p.E125K	NM_004195	NP_004186	Q9Y5U5	TNR18_HUMAN	tumor necrosis factor receptor superfamily,	125	TNFR-Cys 3.|Extracellular (Potential).				anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAGTGGCCTTCGTGGCCCCCG	0.647	GBM(157;472 1934 13810 14591 35952)		NA											10	31					0	0	0.006214	0	0
EPHB2	2048	broad.mit.edu	37	1	23111087	23111087	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:23111087C>A	uc009vqj.1	+	3	474	c.329C>A	c.(328-330)ACC>AAC	p.T110N	EPHB2_uc001bge.2_Missense_Mutation_p.T110N|EPHB2_uc001bgf.2_Missense_Mutation_p.T110N|EPHB2_uc010odu.1_Missense_Mutation_p.T110N	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	110	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TGCAAGGAGACCTTCAACCTC	0.572			NA							Hereditary_Prostate_Cancer				12	21					1.08611e-07	1.39711e-07	0.010729	1	0
C8B	732	broad.mit.edu	37	1	57411544	57411544	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:57411544C>A	uc001cyp.2	-	7	1122	c.1055G>T	c.(1054-1056)GGC>GTC	p.G352V	C8B_uc010oon.1_Missense_Mutation_p.G290V|C8B_uc010ooo.1_Missense_Mutation_p.G300V	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	352	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TTCATAAATGCCCCCAAGCAC	0.517			NA											32	56					9.65021e-13	1.44506e-12	0.010818	1	0
IL12RB2	3595	broad.mit.edu	37	1	67795397	67795397	+	Silent	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:67795397C>T	uc001ddu.2	+	6	1432	c.792C>T	c.(790-792)AGC>AGT	p.S264S	IL12RB2_uc010oqi.1_Silent_p.S264S|IL12RB2_uc010oqj.1_Silent_p.S264S|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Silent_p.S264S|IL12RB2_uc010oqm.1_Silent_p.S264S|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	264	Extracellular (Potential).|Fibronectin type-III 2.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						CCAGTAACAGCAGGCTCTGGA	0.403			NA											15	41					0	0	0.00499	0	0
C1orf173	127254	broad.mit.edu	37	1	75097536	75097536	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:75097536A>C	uc001dgg.2	-	7	899	c.680T>G	c.(679-681)ATT>AGT	p.I227S	C1orf173_uc001dgi.3_Missense_Mutation_p.I21S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	227										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTAACTGTTAATGTTTGGAAG	0.398			NA											38	63					0	0	0.004289	0	0
PKN2	5586	broad.mit.edu	37	1	89270578	89270578	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:89270578A>G	uc001dmn.2	+	10	1817	c.1475A>G	c.(1474-1476)CAA>CGA	p.Q492R	PKN2_uc001dmm.1_Missense_Mutation_p.Q492R|PKN2_uc010osp.1_Missense_Mutation_p.Q476R|PKN2_uc010osq.1_Missense_Mutation_p.Q335R|PKN2_uc009wcv.2_Missense_Mutation_p.Q444R|PKN2_uc010osr.1_Missense_Mutation_p.Q157R	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	492					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		CTTCAAAGACAAAAGAAAATT	0.264			NA											13	35					0	0	0.013537	0	0
COL11A1	1301	broad.mit.edu	37	1	103364517	103364517	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:103364517G>A	uc001dul.2	-	55	4438	c.4120C>T	c.(4120-4122)CAA>TAA	p.Q1374*	COL11A1_uc001duk.2_Nonsense_Mutation_p.Q570*|COL11A1_uc001dum.2_Nonsense_Mutation_p.Q1386*|COL11A1_uc001dun.2_Nonsense_Mutation_p.Q1335*|COL11A1_uc009weh.2_Nonsense_Mutation_p.Q1258*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1374	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTTTCACCTTGTCTTCCCTCT	0.264			NA											8	35					0	0	0.00308	0	0
RPRD2	23248	broad.mit.edu	37	1	150337348	150337348	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:150337348A>G	uc009wlr.2	+	1	359	c.158A>G	c.(157-159)AAA>AGA	p.K53R	RPRD2_uc010pcc.1_Missense_Mutation_p.K53R|RPRD2_uc001eup.3_Missense_Mutation_p.K53R	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	53	CID.						protein binding			ovary(1)	1						GAGAACAAAAAACACCACAGT	0.498			NA											12	52					0	0	0.001855	0	0
HRNR	388697	broad.mit.edu	37	1	152188100	152188100	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:152188100C>G	uc001ezt.1	-	3	6081	c.6005G>C	c.(6004-6006)GGC>GCC	p.G2002A		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2002	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGACCGTAGCCAGAGGACTG	0.567			NA											41	470					0	0	0.007835	0	0
S100A7	6278	broad.mit.edu	37	1	153430323	153430323	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:153430323G>A	uc001fbv.1	-	3	336	c.265C>T	c.(265-267)CAG>TAG	p.Q89*		NM_002963	NP_002954	P31151	S10A7_HUMAN	S100 calcium binding protein A7	89					angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			skin(1)	1	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCATGGCTCTGCTTGTGGTAG	0.527			NA											12	116					0	0	0.00245	0	0
C1orf66	51093	broad.mit.edu	37	1	156703953	156703953	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:156703953G>T	uc001fpu.2	+	6	1423	c.789G>T	c.(787-789)CTG>CTT	p.L263L	C1orf66_uc001fpv.2_Intron	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	263						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGGGGATCTGAGTGTTGCCT	0.632			NA											17	40					4.14922e-12	5.99788e-12	0.004007	1	0
OR6N1	128372	broad.mit.edu	37	1	158736422	158736422	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:158736422G>T	uc010piq.1	-	1	51	c.51C>A	c.(49-51)TTC>TTA	p.F17L		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGAGATGGGGGAAGCCCAAGA	0.483			NA											14	43					1.52009e-12	2.24175e-12	0.003163	1	0
MNDA	4332	broad.mit.edu	37	1	158813853	158813853	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:158813853G>T	uc001fsz.1	+	4	711	c.511G>T	c.(511-513)GAT>TAT	p.D171Y		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	171					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TGCAGCTGTGGATCATCCCCC	0.493			NA											39	166					7.53189e-24	1.32489e-23	0.007835	1	0
ASTN1	460	broad.mit.edu	37	1	176863861	176863861	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:176863861G>A	uc001glc.2	-	17	2989	c.2777C>T	c.(2776-2778)GCG>GTG	p.A926V	ASTN1_uc001glb.1_Missense_Mutation_p.A926V|ASTN1_uc001gld.1_Missense_Mutation_p.A926V	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	934					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GACTCCAGCCGCCATGTGCTT	0.602			NA											25	83					0	0	0.00874	0	0
TATDN3	128387	broad.mit.edu	37	1	212976082	212976082	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:212976082G>A	uc001hjo.2	+	5	392	c.298G>A	c.(298-300)GAT>AAT	p.D100N	TATDN3_uc010ptj.1_Missense_Mutation_p.D100N|TATDN3_uc010ptk.1_Missense_Mutation_p.D100N|TATDN3_uc001hjp.2_Missense_Mutation_p.D100N|TATDN3_uc010ptl.1_Intron|TATDN3_uc010ptm.1_Missense_Mutation_p.D48N	NM_001042552	NP_001036017	Q17R31	TATD3_HUMAN	TatD DNase domain containing 3 isoform 1	100						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)		GAATTATAAGGATCGGTTGTT	0.294			NA											4	54					0	0	0.009096	0	0
ZNF678	339500	broad.mit.edu	37	1	227843491	227843491	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:227843491G>T	uc001hqw.1	+	4	1885	c.1540G>T	c.(1540-1542)GAG>TAG	p.E514*	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	569					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				TTATACTGGAGAGGAACCTGA	0.323			NA											15	65					6.31663e-08	8.16131e-08	0.003163	1	0
HEATR1	55127	broad.mit.edu	37	1	236734657	236734657	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:236734657T>C	uc001hyd.1	-	28	4067	c.3942A>G	c.(3940-3942)ATA>ATG	p.I1314M	HEATR1_uc009xgh.1_Missense_Mutation_p.I476M	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1314					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTACCGGAAATATTCCAGCAA	0.398			NA											16	40					0	0	0.00499	0	0
OR2C3	81472	broad.mit.edu	37	1	247695027	247695027	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:247695027G>T	uc009xgy.2	-	2	1149	c.787C>A	c.(787-789)CCA>ACA	p.P263T	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CTCTTGGCTGGCTGGAGATAC	0.527			NA											27	103					1.66031e-10	2.28684e-10	0.003954	1	0
OR2C3	81472	broad.mit.edu	37	1	247695038	247695038	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:247695038A>T	uc009xgy.2	-	2	1138	c.776T>A	c.(775-777)ATG>AAG	p.M259K	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CTGGAGATACATGAAGATGAT	0.517			NA											28	99					0	0	0.004656	0	0
TUBB8	347688	broad.mit.edu	37	10	93939	93939	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:93939C>G	uc001ifi.2	-	4	393	c.393G>C	c.(391-393)CAG>CAC	p.Q131H	TUBB8_uc009xhe.2_Missense_Mutation_p.Q94H|TUBB8_uc010pzs.1_Missense_Mutation_p.Q59H	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	131					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GCTGGAAACCCTGCAGGCAGT	0.582	Pancreas(192;2041 3010 9013 18103)		NA											14	69					0	0	0.006122	0	0
C10orf18	54906	broad.mit.edu	37	10	5782228	5782228	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:5782228C>T	uc001iij.2	+	13	2720	c.2095C>T	c.(2095-2097)CGG>TGG	p.R699W	C10orf18_uc001iik.2_Intron	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	699										ovary(1)|central_nervous_system(1)	2						CATGCCATTTCGGCATCAGCC	0.532			NA											6	76					0	0	0.00308	0	0
GRID1	2894	broad.mit.edu	37	10	87482866	87482866	+	Missense_Mutation	SNP	G	G	T	rs138984541		TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:87482866G>T	uc001kdl.1	-	12	1992	c.1891C>A	c.(1891-1893)CGC>AGC	p.R631S	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.R202S	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	631	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ATCACGATGCGCATGGCCATG	0.587			NA								Multiple Myeloma(13;0.14)			7	26					0.00198382	0.00221097	0.001984	1	0
CYP2C9	1559	broad.mit.edu	37	10	96740969	96740969	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:96740969A>T	uc001kka.3	+	7	1016	c.991A>T	c.(991-993)ATT>TTT	p.I331F	CYP2C9_uc009xut.2_Missense_Mutation_p.I329F	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	331					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TGAACGTGTGATTGGCAGAAA	0.478	Ovarian(54;1266 1406 16072 35076)		NA											58	97					0	0	0.01441	0	0
NPM3	10360	broad.mit.edu	37	10	103542607	103542607	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:103542607C>A	uc001ktt.2	-	2	216	c.193G>T	c.(193-195)GCA>TCA	p.A65S		NM_006993	NP_008924	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	65							nucleic acid binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		ATGGTTAGTGCCAGCACGTGC	0.542			NA											15	32					1.15088e-07	1.46111e-07	0.004007	1	0
ACTR1A	10121	broad.mit.edu	37	10	104244124	104244124	+	Silent	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:104244124T>A	uc001kvv.2	-	6	558	c.450A>T	c.(448-450)ACA>ACT	p.T150T	ACTR1A_uc010qqn.1_Silent_p.T76T|ACTR1A_uc010qqo.1_Silent_p.T103T	NM_005736	NP_005727	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A,	150					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)	1		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		TGGTCCTGCCTGTAGCGTAAC	0.537			NA											9	20					0	0	0.006214	0	0
NRAP	4892	broad.mit.edu	37	10	115356917	115356917	+	Silent	SNP	A	A	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:115356917A>G	uc001laj.2	-	37	4523	c.4359T>C	c.(4357-4359)AGT>AGC	p.S1453S	NRAP_uc009xyb.2_Silent_p.S242S|NRAP_uc001lak.2_Silent_p.S1418S|NRAP_uc001lal.3_Silent_p.S1453S	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1453						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TGAACTTGATACTGTCTGGTT	0.453			NA											44	125					0	0	0.013114	0	0
GFRA1	2674	broad.mit.edu	37	10	118029077	118029077	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:118029077G>T	uc001lcj.2	-	4	1054	c.356C>A	c.(355-357)TCC>TAC	p.S119Y	GFRA1_uc001lci.2_Missense_Mutation_p.S119Y|GFRA1_uc009xyr.2_Missense_Mutation_p.S119Y	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	119					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TTCATATGGGGAATCCTCCAG	0.393	Ovarian(128;329 1725 45498 46808 50759)		NA											9	29					7.48243e-07	9.33705e-07	0.006214	1	0
GPR26	2849	broad.mit.edu	37	10	125426536	125426536	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:125426536C>A	uc001lhh.2	+	1	666	c.613C>A	c.(613-615)CGC>AGC	p.R205S		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	205	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				CCATTGCAAGCGCATCGACGT	0.632			NA											6	9					3.59834e-05	4.2712e-05	0.001168	1	0
Unknown	0	broad.mit.edu	37	10	134628239	134628239	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr10:134628239G>T	uc010qux.1	-	44	6378	c.6378C>A	c.(6376-6378)CCC>CCA	p.P2126P		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.												NA						GGATGGTCCGGGGGATGCTGC	0.667			NA											16	34					1.5739e-10	2.17809e-10	0.004007	1	0
OR52M1	119772	broad.mit.edu	37	11	4566472	4566472	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:4566472G>T	uc010qyf.1	+	1	52	c.52G>T	c.(52-54)GGC>TGC	p.G18C		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGGCTCACTGGCATCCCAGG	0.532			NA											25	60					2.21704e-12	3.25314e-12	0.00278	1	0
CCKBR	887	broad.mit.edu	37	11	6292734	6292734	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:6292734G>C	uc001mcp.2	+	5	1498	c.1305G>C	c.(1303-1305)AGG>AGC	p.R435S	CCKBR_uc001mcq.2_Missense_Mutation_p.R363S|CCKBR_uc001mcr.2_Missense_Mutation_p.R418S|CCKBR_uc001mcs.2_Missense_Mutation_p.R504S	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	435	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	CGCTGTCCAGGCTTAGCTACA	0.637			NA											13	35					0	0	0.003163	0	0
OR10A2	341276	broad.mit.edu	37	11	6891249	6891249	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:6891249G>A	uc001meu.1	+	1	264	c.264G>A	c.(262-264)ATG>ATA	p.M88I		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	88	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCACTCAGATGTATTTCTTCT	0.522			NA											46	123					0	0	0.01441	0	0
KCNC1	3746	broad.mit.edu	37	11	17757877	17757877	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:17757877C>A	uc001mnk.3	+	1	383	c.328C>A	c.(328-330)CGC>AGC	p.R110S	KCNC1_uc009yhc.1_Missense_Mutation_p.R110S	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	110	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						GATGACGTACCGCCAGCACCG	0.716			NA											13	30					3.27435e-08	4.28749e-08	0.00245	1	0
LDLRAD3	143458	broad.mit.edu	37	11	36103274	36103274	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:36103274T>A	uc001mwk.1	+	3	302	c.265T>A	c.(265-267)TTC>ATC	p.F89I	LDLRAD3_uc010rey.1_Missense_Mutation_p.F40I|LDLRAD3_uc010rez.1_5'UTR	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	89	Extracellular (Potential).|LDL-receptor class A 2.					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				CATTGGTCGCTTCCGGTGCAA	0.527			NA											37	76					0	0	0.004878	0	0
OR8I2	120586	broad.mit.edu	37	11	55861219	55861219	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:55861219G>T	uc010rix.1	+	1	436	c.436G>T	c.(436-438)GTA>TTA	p.V146L		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					CTGGCTGGGAGTAATGCCATA	0.433			NA											30	97					1.55811e-20	2.64516e-20	0.008361	1	0
OR8H1	219469	broad.mit.edu	37	11	56057871	56057871	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:56057871G>T	uc010rje.1	-	1	668	c.668C>A	c.(667-669)ACC>AAC	p.T223N		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T223T(1)		ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					TTTCAGGATGGTAGAGAGAAT	0.398			NA											33	52					5.91797e-21	1.0165e-20	0.012213	1	0
RIN1	9610	broad.mit.edu	37	11	66099844	66099844	+	Missense_Mutation	SNP	G	G	A	rs3181770		TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:66099844G>A	uc001ohn.1	-	10	2382	c.2255C>T	c.(2254-2256)TCT>TTT	p.S752F	RIN1_uc010roy.1_Missense_Mutation_p.S383F|RIN1_uc009yrd.1_Missense_Mutation_p.S445F|RIN1_uc010roz.1_Missense_Mutation_p.S647F|RIN1_uc010rpa.1_Missense_Mutation_p.S586F	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	752					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						AGTTGTCTCAGACTGTTCCCG	0.632			NA											58	100					0	0	0.01441	0	0
SYT12	91683	broad.mit.edu	37	11	66807645	66807645	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:66807645C>T	uc009yrl.2	+	4	822	c.592C>T	c.(592-594)CCG>TCG	p.P198S	SYT12_uc001oju.2_Missense_Mutation_p.P198S	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	198	C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						CAGCCTGCTGCCGGACGAGCA	0.662	Ovarian(65;2862 3307)		NA											3	44					0	0	0.009096	0	0
FAM55B	120406	broad.mit.edu	37	11	114569375	114569375	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:114569375C>A	uc009yyy.2	+	3	839	c.741C>A	c.(739-741)GAC>GAA	p.D247E		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	247						integral to membrane				ovary(1)	1						ACATGGATGACAGAGACCAAG	0.473			NA											15	40					6.72482e-11	9.39545e-11	0.003163	1	0
BCL9L	283149	broad.mit.edu	37	11	118772195	118772195	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:118772195T>A	uc001pug.2	-	6	3222	c.2257A>T	c.(2257-2259)ATG>TTG	p.M753L	BCL9L_uc009zal.2_Missense_Mutation_p.M748L	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	753	Met-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GACTGCCCCATGGGAGGGCTC	0.532			NA											22	48					0	0	0.00278	0	0
UBASH3B	84959	broad.mit.edu	37	11	122666894	122666894	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:122666894C>A	uc001pyi.3	+	8	1504	c.1144C>A	c.(1144-1146)CAG>AAG	p.Q382K		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	382	Protein tyrosine phosphatase (By similarity).					cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		GCCCGGCCCCCAGAAGCGATG	0.542			NA									OREG0021442	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	83					3.73988e-18	6.16975e-18	0.00632	1	0
OR4D5	219875	broad.mit.edu	37	11	123810710	123810710	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:123810710C>A	uc001pzk.1	+	1	387	c.387C>A	c.(385-387)CCC>CCA	p.P129P		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTTCCCAGCCCCTGCACTACA	0.507			NA											33	103					5.43694e-19	9.14099e-19	0.005524	1	0
CHEK1	1111	broad.mit.edu	37	11	125499295	125499295	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr11:125499295C>T	uc009zbo.2	+	5	1256	c.364C>T	c.(364-366)CAT>TAT	p.H122Y	CHEK1_uc010sbh.1_Missense_Mutation_p.H138Y|CHEK1_uc010sbi.1_Missense_Mutation_p.H122Y|CHEK1_uc001qcf.3_Missense_Mutation_p.H122Y|CHEK1_uc009zbp.2_Missense_Mutation_p.H122Y|CHEK1_uc001qcg.3_Missense_Mutation_p.H122Y|CHEK1_uc009zbq.2_Missense_Mutation_p.H122Y|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	122	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		GGTTTATCTGCATGGTATTGG	0.318			NA						Other_conserved_DNA_damage_response_genes					22	54					0	0	0.014323	0	0
CACNA1C	775	broad.mit.edu	37	12	2797830	2797830	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:2797830G>A	uc009zdu.1	+	49	6564	c.6251G>A	c.(6250-6252)GGT>GAT	p.G2084D	CACNA1C_uc009zdv.1_Missense_Mutation_p.G1998D|CACNA1C_uc001qkb.2_Missense_Mutation_p.G2001D|CACNA1C_uc001qkc.2_Missense_Mutation_p.G2020D|CACNA1C_uc001qke.2_Missense_Mutation_p.G1990D|CACNA1C_uc001qkf.2_Missense_Mutation_p.G2009D|CACNA1C_uc001qjz.2_Missense_Mutation_p.G2001D|CACNA1C_uc001qkd.2_Missense_Mutation_p.G2020D|CACNA1C_uc001qkg.2_Missense_Mutation_p.G2007D|CACNA1C_uc009zdw.1_Missense_Mutation_p.G2042D|CACNA1C_uc001qkh.2_Missense_Mutation_p.G2009D|CACNA1C_uc001qkl.2_Missense_Mutation_p.G2049D|CACNA1C_uc001qkn.2_Missense_Mutation_p.G2001D|CACNA1C_uc001qko.2_Missense_Mutation_p.G2021D|CACNA1C_uc001qkp.2_Missense_Mutation_p.G2001D|CACNA1C_uc001qkr.2_Missense_Mutation_p.G2018D|CACNA1C_uc001qku.2_Missense_Mutation_p.G2036D|CACNA1C_uc001qkq.2_Missense_Mutation_p.G2029D|CACNA1C_uc001qks.2_Missense_Mutation_p.G2001D|CACNA1C_uc001qkt.2_Missense_Mutation_p.G2020D|CACNA1C_uc001qki.1_Missense_Mutation_p.G1808D|CACNA1C_uc001qkj.1_Missense_Mutation_p.G1772D|CACNA1C_uc001qkk.1_Missense_Mutation_p.G1737D|CACNA1C_uc001qkm.1_Missense_Mutation_p.G1797D|CACNA1C_uc010sea.1_Missense_Mutation_p.G692D|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.G319D	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	2084	Poly-Gly.|Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACCACCCCCGGTGGCGGGGGC	0.711			NA											11	25					0	0	0.010729	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4657319	4657319	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:4657319T>G	uc001qmw.2	+	6	588	c.432T>G	c.(430-432)AAT>AAG	p.N144K	RAD51AP1_uc001qmu.2_Missense_Mutation_p.N127K|RAD51AP1_uc001qmv.2_Missense_Mutation_p.N90K|RAD51AP1_uc010sep.1_Missense_Mutation_p.N9K|RAD51AP1_uc010seq.1_Missense_Mutation_p.N9K|RAD51AP1_uc009zeg.2_5'Flank	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	144					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			ATATCTCTAATTGCAGTGTAG	0.274			NA											8	126					0	0	0.00308	0	0
RERGL	79785	broad.mit.edu	37	12	18237478	18237478	+	Missense_Mutation	SNP	C	C	T	rs61757396	byFrequency	TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:18237478C>T	uc001rdq.2	-	5	502	c.308G>A	c.(307-309)CGG>CAG	p.R103Q	RERGL_uc001rdr.2_Missense_Mutation_p.R102Q	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	103	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						TTGTGGCTCCCGGATTCTGTA	0.383			NA											12	95					0	0	0.001855	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			10	11					0	0	0.010729	0	0
OR8S1	341568	broad.mit.edu	37	12	48921695	48921695	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:48921695G>A	uc010slu.1	+	2	889	c.889G>A	c.(889-891)GGG>AGG	p.G297R		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTGTTACAAGGGGGAAAGAAG	0.468			NA											19	45					0	0	0.008871	0	0
MCRS1	10445	broad.mit.edu	37	12	49954103	49954103	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:49954103C>G	uc001ruk.1	-	9	1047	c.856G>C	c.(856-858)GAC>CAC	p.D286H	MCRS1_uc001rui.1_Missense_Mutation_p.D299H|MCRS1_uc001ruj.1_Missense_Mutation_p.D273H|MCRS1_uc001rul.1_Missense_Mutation_p.D286H|MCRS1_uc009zlj.1_Missense_Mutation_p.D95H|MCRS1_uc001rum.1_Missense_Mutation_p.D273H	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	286					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						TCAATCAGGTCCTCTGCATCA	0.577			NA											107	291					0	0	0.01441	0	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:57485446T>C	uc001smz.2	+	2	1000	c.622T>C	c.(622-624)TTC>CTC	p.F208L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCGCCCCCCTTCTCCCCCCC	0.716			NA											5	30					0	0	0.001984	0	0
GEFT	115557	broad.mit.edu	37	12	58007844	58007844	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:58007844C>T	uc001spb.2	+	6	1058	c.598C>T	c.(598-600)CGA>TGA	p.R200*	GEFT_uc009zpy.2_Nonsense_Mutation_p.R239*|GEFT_uc001soz.1_Nonsense_Mutation_p.R74*|GEFT_uc001spa.2_Nonsense_Mutation_p.R94*|uc001spc.2_Intron|GEFT_uc001spd.2_5'UTR	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	200	DH.				regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					CGAGAGTCTTCGAGGCCGTGA	0.567			NA											11	101					0	0	0.010729	0	0
TPH2	121278	broad.mit.edu	37	12	72335413	72335413	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:72335413G>A	uc009zrw.1	+	2	296	c.155G>A	c.(154-156)AGC>AAC	p.S52N	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	52					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	AACAAGGGAAGCAGCAAACGT	0.413			NA											13	43					0	0	0.001855	0	0
LIN7A	8825	broad.mit.edu	37	12	81239642	81239642	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:81239642C>A	uc001szj.1	-	4	543	c.350G>T	c.(349-351)GGC>GTC	p.G117V	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	117	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						AAAACCAAGGCCTTCATCAGT	0.458			NA											18	64					3.52763e-06	4.34628e-06	0.00499	1	0
DDX54	79039	broad.mit.edu	37	12	113600946	113600946	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:113600946C>T	uc001tup.2	-	16	2100	c.2072G>A	c.(2071-2073)AGC>AAC	p.S691N	DDX54_uc001tuq.3_Missense_Mutation_p.S691N	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	691					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						CCCCCGCTCGCTGTCAAAGTC	0.647			NA											4	22					0	0	0.001168	0	0
PABPC3	5042	broad.mit.edu	37	13	25671157	25671157	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr13:25671157C>A	uc001upy.2	+	1	882	c.821C>A	c.(820-822)ACG>AAG	p.T274K		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	274					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GAACGGCAGACGGAACTTAAG	0.393			NA											37	89					2.09667e-21	3.62264e-21	0.003755	1	0
ENOX1	55068	broad.mit.edu	37	13	43930271	43930271	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr13:43930271C>A	uc001uza.3	-	8	907	c.607G>T	c.(607-609)GGG>TGG	p.G203W	ENOX1_uc001uzb.3_Missense_Mutation_p.G203W|ENOX1_uc001uzc.3_Missense_Mutation_p.G203W|ENOX1_uc001uyz.3_Translation_Start_Site|ENOX1_uc010tfm.1_Missense_Mutation_p.G16W	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	203	RRM.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GTGCTAGACCCTAATCGCATC	0.502			NA											10	33					0.000673444	0.000756329	0.008291	1	0
SLITRK1	114798	broad.mit.edu	37	13	84454347	84454347	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr13:84454347G>T	uc001vlk.2	-	1	2182	c.1296C>A	c.(1294-1296)AGC>AGA	p.S432R		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	432	LRR 9.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCAGGTAATTGCTATCCATGT	0.498			NA											39	112					3.78316e-11	5.36253e-11	0.00623	1	0
TMTC4	84899	broad.mit.edu	37	13	101308647	101308647	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr13:101308647C>A	uc001vou.2	-	5	731	c.571G>T	c.(571-573)GCA>TCA	p.A191S	TMTC4_uc001vot.2_Missense_Mutation_p.A210S|TMTC4_uc010tja.1_Missense_Mutation_p.A80S	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	191						integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCTCTAAATGCTTTACAGTAG	0.418			NA											20	29					1.28384e-07	1.62286e-07	0.012319	1	0
COL4A1	1282	broad.mit.edu	37	13	110817329	110817329	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr13:110817329C>A	uc001vqw.3	-	46	4152	c.4030G>T	c.(4030-4032)GGT>TGT	p.G1344C	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1344	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAGGAGGACCCGGGAGACCT	0.592			NA											6	24					4.096e-09	5.46133e-09	0.001168	1	0
ADCY4	196883	broad.mit.edu	37	14	24800251	24800251	+	Silent	SNP	G	G	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr14:24800251G>C	uc001wov.2	-	6	909	c.903C>G	c.(901-903)CTC>CTG	p.L301L	ADCY4_uc001wow.2_Silent_p.L301L|ADCY4_uc010toh.1_5'UTR|ADCY4_uc001wox.2_Silent_p.L301L|ADCY4_uc001woy.2_Silent_p.L301L	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	301	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		ACTTGCCAAAGAGCTCATTGA	0.577			NA											16	25					0	0	0.004007	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885566	24885566	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr14:24885566G>A	uc001wpf.3	+	9	4929	c.4611G>A	c.(4609-4611)CCG>CCA	p.P1537P		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1537					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GGGTAGTCCCGACGCAACTCC	0.547			NA											8	17					0	0	0.00308	0	0
C14orf115	55237	broad.mit.edu	37	14	74825221	74825221	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr14:74825221G>T	uc001xpw.3	+	2	1926	c.1735G>T	c.(1735-1737)GAG>TAG	p.E579*		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	579					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GCAGGAGAAGGAGGCTGGCAG	0.642			NA											23	63					1.17739e-12	1.75408e-12	0.005443	1	0
DIO2	1734	broad.mit.edu	37	14	80677806	80677807	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr14:80677806_80677807GG>TT	uc010tvq.1	-	2	411_412	c.9_10CC>AA	c.(7-12)ATCCTC>ATAATC	p.L4I	uc001xuw.1_RNA|DIO2_uc010tvp.1_Missense_Mutation_p.L4I|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_Missense_Mutation_p.L4I|DIO2_uc010tvr.1_Missense_Mutation_p.L4I|DIO2_uc010asy.2_Missense_Mutation_p.L4I	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	4					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		TCTACGCTGAGGATGCCCATCT	0.52			NA											6	12					0	0	0.004672	0	0
OR4M2	390538	broad.mit.edu	37	15	22369024	22369024	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr15:22369024G>T	uc010tzu.1	+	1	449	c.449G>T	c.(448-450)AGG>ATG	p.R150M	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTCTCCTGGAGGGGGGGCTTC	0.502			NA											54	493					4.13886e-29	7.36919e-29	0.01441	1	0
OR4M2	390538	broad.mit.edu	37	15	22369051	22369051	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr15:22369051A>G	uc010tzu.1	+	1	476	c.476A>G	c.(475-477)CAG>CGG	p.Q159R	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTATCATACAGGTGGCTCTC	0.512			NA											70	517					0	0	0.01441	0	0
BAHD1	22893	broad.mit.edu	37	15	40751953	40751953	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr15:40751953C>A	uc001zlu.2	+	2	1361	c.1290C>A	c.(1288-1290)CAC>CAA	p.H430Q	BAHD1_uc001zlt.2_Missense_Mutation_p.H430Q|BAHD1_uc010bbp.1_Missense_Mutation_p.H430Q|BAHD1_uc001zlv.2_Missense_Mutation_p.H430Q	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	430					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CTTTCCAGCACCCTCCCTGGG	0.627			NA											3	50					0.004672	0.00507146	0.004672	1	0
HDC	3067	broad.mit.edu	37	15	50546389	50546389	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr15:50546389G>T	uc001zxz.2	-	6	764	c.658C>A	c.(658-660)CGA>AGA	p.R220R	HDC_uc001zxy.2_5'Flank|HDC_uc010uff.1_Silent_p.R220R|HDC_uc010bet.1_Silent_p.R141R|HDC_uc010beu.1_Silent_p.R220R	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	220					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	GCTTCCCCTCGGAGTGAGAAG	0.488	GBM(95;1627 1936 6910 9570)		NA											26	56					1.55469e-16	2.5504e-16	0.00333	1	0
DENND4A	10260	broad.mit.edu	37	15	65989642	65989642	+	Silent	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr15:65989642T>C	uc002aph.2	-	20	3159	c.2781A>G	c.(2779-2781)CAA>CAG	p.Q927Q	DENND4A_uc002api.2_Silent_p.Q970Q|DENND4A_uc002apj.3_Silent_p.Q927Q	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	927	Bipartite nuclear localization signal (Potential).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CTTTTTCTTCTTGAATGTCTT	0.308			NA											48	96					0	0	0.01441	0	0
KIAA1199	57214	broad.mit.edu	37	15	81201518	81201518	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr15:81201518G>A	uc002bfw.1	+	13	1928	c.1668G>A	c.(1666-1668)CCG>CCA	p.P556P	KIAA1199_uc010unn.1_Silent_p.P556P	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	556										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GTCAGTACCCGATTCACTTCC	0.547			NA											13	63					0	0	0.00245	0	0
SLC28A1	9154	broad.mit.edu	37	15	85438235	85438235	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr15:85438235C>A	uc002blg.2	+	6	544	c.342C>A	c.(340-342)GTC>GTA	p.V114V	SLC28A1_uc010upd.1_Silent_p.V36V|SLC28A1_uc010bnb.2_Silent_p.V114V|SLC28A1_uc010upe.1_Silent_p.V114V|SLC28A1_uc010upf.1_Silent_p.V114V|SLC28A1_uc010upg.1_Silent_p.V114V|SLC28A1_uc002blf.2_Silent_p.V114V	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	114	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCTGTTTGTCCTCACCTGTG	0.637			NA											25	95					1.64293e-13	2.53829e-13	0.00333	1	0
ZNF263	10127	broad.mit.edu	37	16	3334041	3334041	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr16:3334041C>T	uc002cuq.2	+	1	555	c.223C>T	c.(223-225)CGC>TGC	p.R75C	ZNF263_uc010uww.1_Intron|ZNF263_uc002cup.2_Missense_Mutation_p.R75C	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	75	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						GCCTGAGATGCGCACGAAGGA	0.622			NA											4	102					0	0	0.000602	0	0
SYT17	51760	broad.mit.edu	37	16	19236108	19236108	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr16:19236108C>G	uc002dfw.2	+	7	1507	c.1176C>G	c.(1174-1176)TTC>TTG	p.F392L	SYT17_uc002dfx.2_Missense_Mutation_p.F331L|SYT17_uc002dfy.2_Missense_Mutation_p.F388L|SYT17_uc002dfv.1_Missense_Mutation_p.F331L	NM_016524	NP_057608	Q9BSW7	SYT17_HUMAN	B/K protein	392	C2 2.					membrane|synaptic vesicle	transporter activity			ovary(1)	1						ATGAATCCTTCAGCTTCAAAG	0.448			NA											39	93					0	0	0.01441	0	0
ACSM5	54988	broad.mit.edu	37	16	20435240	20435240	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr16:20435240G>T	uc002dhe.2	+	6	917	c.770G>T	c.(769-771)CGG>CTG	p.R257L		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	257					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TTTGGCAGACGGTGGGTGGCC	0.483			NA											44	160					4.53413e-08	5.91056e-08	0.013114	1	0
ZNF423	23090	broad.mit.edu	37	16	49672667	49672667	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr16:49672667C>A	uc002efs.2	-	5	694	c.396G>T	c.(394-396)GGG>GGT	p.G132G	ZNF423_uc010vgn.1_Silent_p.G15G	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	132					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGCCCGTGCCCCCTTCCTCCT	0.607			NA											14	42					4.3838e-07	5.49386e-07	0.001855	1	0
TOX3	27324	broad.mit.edu	37	16	52502441	52502441	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr16:52502441C>A	uc002egw.2	-	2	304	c.133G>T	c.(133-135)GCG>TCG	p.A45S	TOX3_uc010vgt.1_Missense_Mutation_p.A41S|TOX3_uc010vgu.1_Missense_Mutation_p.A45S	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	45					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						GCGAAGAACGCATTGTTCGCC	0.353			NA											37	83					4.90274e-10	6.65861e-10	0.00623	1	0
DUS2L	54920	broad.mit.edu	37	16	68109324	68109324	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr16:68109324G>T	uc002evi.2	+	14	1148	c.999G>T	c.(997-999)AGG>AGT	p.R333S	DUS2L_uc002evj.2_Missense_Mutation_p.R333S|DUS2L_uc010vkk.1_Missense_Mutation_p.R298S|DUS2L_uc010cez.2_Missense_Mutation_p.R246S	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	333					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		AGCAGGCCAGGCTCTCAGCCA	0.547			NA											10	28					2.17888e-05	2.60751e-05	0.006214	1	0
ABR	29	broad.mit.edu	37	17	1003898	1003898	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr17:1003898G>C	uc002fsd.2	-	3	434	c.324C>G	c.(322-324)AAC>AAG	p.N108K	ABR_uc002fse.2_Missense_Mutation_p.N62K|ABR_uc002fsg.2_Missense_Mutation_p.N71K|ABR_uc010cjq.1_Missense_Mutation_p.N120K	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	108	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CTTCCAGCTGGTTAATGTAGA	0.582	Esophageal Squamous(197;2016 2115 4129 29033 46447)		NA											11	108					0	0	0.010729	0	0
GPATCH8	23131	broad.mit.edu	37	17	42483385	42483385	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr17:42483385C>T	uc002igw.1	-	7	591	c.527G>A	c.(526-528)CGA>CAA	p.R176Q	GPATCH8_uc002igv.1_Missense_Mutation_p.R98Q|GPATCH8_uc010wiz.1_Missense_Mutation_p.R98Q	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	176						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		AGAGACATTTCGAGCAAACTC	0.423			NA											4	112					0	0	0.009096	0	0
CACNG5	27091	broad.mit.edu	37	17	64876776	64876776	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr17:64876776T>G	uc010wqi.1	+	4	623	c.386T>G	c.(385-387)ATA>AGA	p.I129R	CACNG5_uc002jfr.2_Missense_Mutation_p.I129R|CACNG5_uc010wqj.1_Missense_Mutation_p.I129R	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	129	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CACCGGACGATACTGGCCTTT	0.423			NA											65	153					0	0	0.01441	0	0
POTEC	388468	broad.mit.edu	37	18	14542880	14542880	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr18:14542880G>T	uc010dln.2	-	1	720	c.266C>A	c.(265-267)TCC>TAC	p.S89Y	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	89										skin(3)	3						CTTCATAAAGGAGTTGTCATG	0.607			NA											55	285					6.56871e-35	1.21396e-34	0.01441	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14784490	14784490	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr18:14784490C>G	uc010dlo.2	+	14	1808	c.1628C>G	c.(1627-1629)CCA>CGA	p.P543R	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	543										ovary(1)|skin(1)	2						AAGACTGTTCCAAATAAAGCC	0.303			NA											12	34					0	0	0.013537	0	0
DSG4	147409	broad.mit.edu	37	18	28986162	28986162	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr18:28986162T>A	uc002kwq.2	+	12	1894	c.1759T>A	c.(1759-1761)TGT>AGT	p.C587S	DSG4_uc002kwr.2_Missense_Mutation_p.C587S	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	587	Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GTTATATGCCTGTGATTGCGA	0.478			NA											25	64					0	0	0.003954	0	0
DTNA	1837	broad.mit.edu	37	18	32400802	32400802	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr18:32400802C>A	uc010dmn.1	+	8	925	c.924C>A	c.(922-924)AGC>AGA	p.S308R	DTNA_uc002kxu.2_Missense_Mutation_p.S308R|DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.S308R|DTNA_uc002kxw.2_Missense_Mutation_p.S308R|DTNA_uc002kxx.2_Missense_Mutation_p.S308R|DTNA_uc010dmj.2_Missense_Mutation_p.S308R|DTNA_uc002kxz.2_Missense_Mutation_p.S308R|DTNA_uc002kxy.2_Missense_Mutation_p.S308R|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.S308R|DTNA_uc002kyb.3_Missense_Mutation_p.S308R|DTNA_uc010dmm.2_Missense_Mutation_p.S308R|DTNA_uc010xby.1_Missense_Mutation_p.S58R|DTNA_uc010dmo.2_Translation_Start_Site|DTNA_uc002kyd.3_Translation_Start_Site|DTNA_uc010xbz.1_Translation_Start_Site|DTNA_uc010xca.1_Translation_Start_Site|DTNA_uc002kye.2_Translation_Start_Site	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	308					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						AGTCCCTGAGCTGTGCTTCCA	0.468			NA											26	56					3.6726e-16	5.95778e-16	0.003954	1	0
MYO5B	4645	broad.mit.edu	37	18	47566513	47566513	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr18:47566513C>A	uc002leb.2	-	3	598	c.310G>T	c.(310-312)GGT>TGT	p.G104C	MYO5B_uc002lec.1_Missense_Mutation_p.G103C	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	104	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CCCCACTTACCACAGTAAGTG	0.458			NA											55	95					1.54043e-34	2.82897e-34	0.01441	1	0
CPLX4	339302	broad.mit.edu	37	18	56963966	56963966	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr18:56963966G>T	uc002lhy.2	-	3	634	c.447C>A	c.(445-447)ATC>ATA	p.I149I		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	149					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				CTGTCTGCTTGATTTCAGTGA	0.498			NA											13	44					1.5739e-10	2.17809e-10	0.004007	1	0
SERPINB4	6318	broad.mit.edu	37	18	61310721	61310721	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr18:61310721G>T	uc002ljf.2	-	2	177	c.91C>A	c.(91-93)CCT>ACT	p.P31T	SERPINB4_uc002lje.2_Missense_Mutation_p.P31T|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	31					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						ATGCTGATAGGGGAATAGAAG	0.423			NA											41	107					2.2871e-25	4.04747e-25	0.007835	1	0
STK11	6794	broad.mit.edu	37	19	1220640	1220640	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:1220640C>T	uc002lrl.1	+	5	1773	c.658C>T	c.(658-660)CAG>TAG	p.Q220*		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	220	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.Q220*(3)|p.?(2)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGGCTTTCCAGCCGCCCGA	0.711			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			13	10					0	0	0.001855	0	0
MUC16	94025	broad.mit.edu	37	19	9091467	9091467	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:9091467G>T	uc002mkp.2	-	1	552	c.348C>A	c.(346-348)AAC>AAA	p.N116K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	116	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGCAGGGTAGTTCCTAGAGG	0.502			NA											73	54					3.12118e-38	5.805e-38	0.01441	1	0
KEAP1	9817	broad.mit.edu	37	19	10610246	10610246	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:10610246A>G	uc002moq.1	-	2	620	c.464T>C	c.(463-465)GTC>GCC	p.V155A	KEAP1_uc002mor.1_Missense_Mutation_p.V155A	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ACCGTTCATGACGTGGAGGAC	0.587			NA											37	22					0	0	0.004289	0	0
SLC25A42	284439	broad.mit.edu	37	19	19215725	19215725	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:19215725C>T	uc002nlf.1	+	4	342	c.191C>T	c.(190-192)TCT>TTT	p.S64F	SLC25A42_uc010xqn.1_Missense_Mutation_p.S116F	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	64	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			TTTCCAGTGTCTTCAAAAAGA	0.557			NA											12	11					0	0	0.00245	0	0
CHST8	64377	broad.mit.edu	37	19	34263296	34263296	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:34263296C>A	uc002nus.3	+	5	1108	c.603C>A	c.(601-603)GGC>GGA	p.G201G	CHST8_uc002nut.3_Silent_p.G201G|CHST8_uc002nuu.2_Silent_p.G201G	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	201	PAPS (By similarity).|Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					CCAAGGCCGGCTGCTCCAATT	0.687			NA											6	94					5.18039e-06	6.35577e-06	0.00308	1	0
GAPDHS	26330	broad.mit.edu	37	19	36034719	36034719	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:36034719C>A	uc002oaf.1	+	9	1162	c.1046C>A	c.(1045-1047)ACC>AAC	p.T349N	uc010eec.1_RNA|uc002oag.2_Intron|TMEM147_uc002oai.1_5'Flank|TMEM147_uc002oaj.1_5'Flank|TMEM147_uc002oak.1_5'Flank	NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	349					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	CTTGCCTACACCGAGGATGAG	0.622			NA											18	16					5.3912e-06	6.58674e-06	0.006122	1	0
NFKBID	84807	broad.mit.edu	37	19	36387872	36387872	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:36387872G>A	uc002oci.1	-	5	669	c.95C>T	c.(94-96)GCT>GTT	p.A32V	NFKBID_uc002och.1_5'Flank|NFKBID_uc002ocj.1_Missense_Mutation_p.A47V	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	32					inflammatory response	nucleus					0						CAGCATGTGAGCTCGGGCCAC	0.622			NA											24	86					0	0	0.014323	0	0
FCGBP	8857	broad.mit.edu	37	19	40433188	40433188	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:40433188C>T	uc002omp.3	-	2	1089	c.1081G>A	c.(1081-1083)GTG>ATG	p.V361M		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	361	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GTCTGTGCCACTACCAGGGCC	0.607			NA											9	46					0	0	0.006214	0	0
SNRPA	6626	broad.mit.edu	37	19	41263354	41263354	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:41263354G>T	uc002ooz.2	+	2	726	c.191G>T	c.(190-192)AGC>ATC	p.S64I	SNRPA_uc002opa.2_Missense_Mutation_p.S14I	NM_004596	NP_004587	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	64	RRM 1.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			skin(2)|ovary(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GAGGTCAGCAGCGCCACCAAC	0.542			NA											41	46					6.1207e-33	1.11009e-32	0.013114	1	0
C19orf61	56006	broad.mit.edu	37	19	44251904	44251904	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:44251904G>A	uc002oxj.2	-	4	714	c.371C>T	c.(370-372)CCA>CTA	p.P124L	C19orf61_uc002oxk.2_Missense_Mutation_p.P124L|C19orf61_uc010eiy.1_Missense_Mutation_p.P124L	NM_019108	NP_061981	Q9H0W8	SMG9_HUMAN	SMG9 protein	124	Pro-rich.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)				AGGGGGTGGTGGGGCGGTGCC	0.682			NA											28	16					0	0	0.00632	0	0
LRRC4B	94030	broad.mit.edu	37	19	51021872	51021872	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:51021872G>C	uc002pss.2	-	3	1235	c.1098C>G	c.(1096-1098)ATC>ATG	p.I366M		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	366	Extracellular (Potential).|Ig-like C2-type.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GCGGCTCCACGATGACGGGCG	0.667			NA											7	30					0	0	0.00308	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51630545	51630545	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:51630545C>A	uc002pvu.2	+	4	1074	c.1007C>A	c.(1006-1008)TCC>TAC	p.S336Y	SIGLEC9_uc010yct.1_Missense_Mutation_p.S336Y	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	336	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTGAACGTCTCCCTGCAGAGT	0.597			NA											4	9					0.00909568	0.00972871	0.009096	1	0
LILRA2	11027	broad.mit.edu	37	19	55086241	55086241	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:55086241G>A	uc002qgg.3	+	4	485	c.396G>A	c.(394-396)GTG>GTA	p.V132V	LILRA2_uc010ern.2_Silent_p.V132V|LILRA2_uc002qgf.2_Silent_p.V132V|LILRA2_uc010yfe.1_Silent_p.V132V|LILRA2_uc010yff.1_Silent_p.V120V|LILRA2_uc010ero.2_Silent_p.V120V|LILRA2_uc010yfg.1_Silent_p.V132V	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	132	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCAGCCCTGTGGTGACCTTAG	0.562			NA											47	171					0	0	0.01441	0	0
NLRP13	126204	broad.mit.edu	37	19	56423822	56423822	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:56423822C>A	uc010ygg.1	-	5	1386	c.1361G>T	c.(1360-1362)AGT>ATT	p.S454I		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	454	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GGCATACAGACTGGTGGTAGT	0.527			NA											43	125					6.21074e-16	1.00195e-15	0.011902	1	0
CAD	790	broad.mit.edu	37	2	27459689	27459689	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:27459689C>T	uc002rji.2	+	27	4549	c.4387C>T	c.(4387-4389)CGA>TGA	p.R1463*	CAD_uc010eyw.2_Nonsense_Mutation_p.R1400*	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1463	DHOase (dihydroorotase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AAAGCTTGTGCGACTGCCGGG	0.572			NA											4	111					0	0	0.001168	0	0
ALK	238	broad.mit.edu	37	2	29455189	29455189	+	Missense_Mutation	SNP	G	G	T	rs150557024	byFrequency	TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:29455189G>T	uc002rmy.2	-	15	3520	c.2613C>A	c.(2611-2613)AAC>AAA	p.N871K		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	871	Gly-rich.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CGGAATTGCCGTTTAGCCCTA	0.617			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				26	49					9.39395e-14	1.45906e-13	0.00632	1	0
NLRC4	58484	broad.mit.edu	37	2	32476218	32476218	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:32476218G>T	uc002roi.2	-	4	961	c.715C>A	c.(715-717)CTG>ATG	p.L239M	NLRC4_uc002roj.1_Missense_Mutation_p.L239M|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	239	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CTCTGCCGCAGCTTCAGCAGC	0.502			NA											40	93					8.69298e-16	1.3947e-15	0.006999	1	0
VIT	5212	broad.mit.edu	37	2	37035875	37035875	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:37035875G>T	uc002rpl.2	+	15	1871	c.1650G>T	c.(1648-1650)GGG>GGT	p.G550G	VIT_uc002rpm.2_Silent_p.G528G|VIT_uc010ezv.2_Silent_p.G506G|VIT_uc010ezw.2_Silent_p.G507G	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	535	VWFA 2.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CGCGCATCGGGGCCGTGCAGT	0.582			NA											14	46					4.93089e-13	7.49906e-13	0.00245	1	0
HEATR5B	54497	broad.mit.edu	37	2	37302722	37302722	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:37302722C>T	uc002rpp.1	-	5	599	c.503G>A	c.(502-504)GGT>GAT	p.G168D		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	168							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				TGCTGCACCACCCAGTCCACT	0.413			NA											27	105					0	0	0.004656	0	0
Unknown	0	broad.mit.edu	37	2	38709705	38709705	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:38709705C>A	uc002rqu.1	+	2	595	c.528C>A	c.(526-528)ACC>ACA	p.T176T						SubName: Full=RPLP0 protein;												NA						GCATCAGTACCCCATTCTATC	0.502			NA											29	44					5.60225e-13	8.47594e-13	0.009535	1	0
MSH2	4436	broad.mit.edu	37	2	47630474	47630474	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:47630474G>A	uc002rvy.1	+	1	212	c.144G>A	c.(142-144)GAG>GAA	p.E48E	MSH2_uc010yoh.1_Intron|MSH2_uc002rvz.2_Silent_p.E48E|MSH2_uc010fbf.1_Silent_p.E48E	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	48					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding			large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CGCACGGCGAGGACGCGCTGC	0.687			NA	D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				8	25					0	0	0.006214	0	0
ADD2	119	broad.mit.edu	37	2	70906010	70906010	+	Silent	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:70906010C>G	uc002sgz.2	-	11	1674	c.1209G>C	c.(1207-1209)ACG>ACC	p.T403T	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Silent_p.T403T|ADD2_uc002sha.2_Intron|ADD2_uc002sgx.2_Silent_p.T403T|ADD2_uc010fdt.1_Silent_p.T403T|ADD2_uc002shc.1_Silent_p.T403T|ADD2_uc002shd.1_Intron|ADD2_uc010fdu.1_Silent_p.T419T	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	403					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						AGGCTGTGACCGTGGCTGGAA	0.542			NA											17	121					0	0	0.004007	0	0
POLR1A	25885	broad.mit.edu	37	2	86305001	86305001	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:86305001T>A	uc002sqs.2	-	11	1740	c.1361A>T	c.(1360-1362)AAC>ATC	p.N454I		NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	454					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TCCAATTTCGTTGGTGTTGAT	0.368			NA											53	138					0	0	0.01441	0	0
PTPN4	5775	broad.mit.edu	37	2	120714600	120714600	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:120714600A>T	uc002tmf.1	+	22	2851	c.2080A>T	c.(2080-2082)ACA>TCA	p.T694S	PTPN4_uc010flj.1_Missense_Mutation_p.T407S|PTPN4_uc010yyr.1_Missense_Mutation_p.T327S	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	694	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	AGATGATGCCACACGGGTCAT	0.274			NA											16	32					0	0	0.00499	0	0
XIRP2	129446	broad.mit.edu	37	2	168107287	168107287	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:168107287A>C	uc002udx.2	+	8	9403	c.9385A>C	c.(9385-9387)ACT>CCT	p.T3129P	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.T2954P|XIRP2_uc010fpq.2_Missense_Mutation_p.T2907P|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2954					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AATAGAATCTACTGCCCGACG	0.443			NA											26	58					0	0	0.005443	0	0
TTN	7273	broad.mit.edu	37	2	179648491	179648491	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:179648491G>T	uc010zfg.1	-	17	3021	c.2797C>A	c.(2797-2799)CCA>ACA	p.P933T	TTN_uc010zfh.1_Missense_Mutation_p.P887T|TTN_uc010zfi.1_Missense_Mutation_p.P887T|TTN_uc010zfj.1_Missense_Mutation_p.P887T|TTN_uc002unb.2_Missense_Mutation_p.P933T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	933							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGGTGCTGGTACTCTTGCT	0.348			NA											22	83					7.92952e-12	1.1406e-11	0.003954	1	0
ABCA12	26154	broad.mit.edu	37	2	215821447	215821447	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:215821447A>T	uc002vew.2	-	42	6393	c.6173T>A	c.(6172-6174)TTA>TAA	p.L2058*	ABCA12_uc002vev.2_Nonsense_Mutation_p.L1740*|ABCA12_uc010zjn.1_Nonsense_Mutation_p.L985*	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2058					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GAATGCAGGTAATTTGAAAAT	0.358	Ovarian(66;664 1488 5121 34295)		NA											22	84					0	0	0.00333	0	0
MARCH4	57574	broad.mit.edu	37	2	217142428	217142428	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:217142428C>A	uc002vgb.2	-	3	2599	c.832G>T	c.(832-834)GGG>TGG	p.G278W		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	278	Helical; (Potential).					Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		CCATACATCCCGTAGCAGATC	0.557			NA											39	105					2.66277e-13	4.07082e-13	0.006999	1	0
PAK7	57144	broad.mit.edu	37	20	9546928	9546928	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr20:9546928C>A	uc002wnl.2	-	6	1639	c.1094G>T	c.(1093-1095)GGC>GTC	p.G365V	PAK7_uc002wnk.2_Missense_Mutation_p.G365V|PAK7_uc002wnj.2_Missense_Mutation_p.G365V|PAK7_uc010gby.1_Missense_Mutation_p.G365V	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	365	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGAGGAATAGCCCGATTTGCT	0.562			NA											45	145					2.81731e-22	4.92607e-22	0.01441	1	0
FOXS1	2307	broad.mit.edu	37	20	30433325	30433325	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr20:30433325G>A	uc002wwt.1	-	1	96	c.21C>T	c.(19-21)CCC>CCT	p.P7P		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	7					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						CGCCAGGCCCGGGCAGAGGCT	0.682			NA											26	44					0	0	0.00632	0	0
CHD6	84181	broad.mit.edu	37	20	40050551	40050551	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr20:40050551C>A	uc002xka.1	-	31	4902	c.4724G>T	c.(4723-4725)TGG>TTG	p.W1575L		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1575					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CCCACACTCCCACCAGACTGG	0.567			NA											11	35					3.86212e-05	4.54733e-05	0.008291	1	0
ZSWIM3	140831	broad.mit.edu	37	20	44505453	44505453	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr20:44505453G>A	uc002xqd.2	+	2	459	c.256G>A	c.(256-258)GAG>AAG	p.E86K	ZSWIM3_uc010zxg.1_Missense_Mutation_p.E80K	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	86							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				AAGGTACAACGAGAGACTAGA	0.473			NA											19	101					0	0	0.008871	0	0
PREX1	57580	broad.mit.edu	37	20	47276591	47276591	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr20:47276591T>G	uc002xtw.1	-	16	1770	c.1747A>C	c.(1747-1749)AAG>CAG	p.K583Q		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	583	DEP 2.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AACTCGCTCTTCTCCAGCACT	0.433			NA											3	90					0	0	0.004672	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253450	32253450	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr21:32253450G>T	uc002yov.2	-	1	425	c.394C>A	c.(394-396)CAA>AAA	p.Q132K		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	132	3.|4 X 10 AA approximate repeats.					keratin filament	structural molecule activity			pancreas(1)	1						CCCACTGGTTGGCAGACAGTA	0.597			NA											12	75					3.07112e-06	3.79986e-06	0.010729	1	0
IL17RA	23765	broad.mit.edu	37	22	17589773	17589773	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr22:17589773G>T	uc002zly.2	+	13	1797	c.1664G>T	c.(1663-1665)GGG>GTG	p.G555V	IL17RA_uc010gqt.2_Missense_Mutation_p.G503V	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	555	Cytoplasmic (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GAGCTGTCGGGGGACAACTAC	0.677			NA											4	12					0.00909568	0.00972871	0.009096	1	0
CECR1	51816	broad.mit.edu	37	22	17688152	17688152	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr22:17688152G>A	uc002zmk.1	-	2	563	c.351C>T	c.(349-351)GGC>GGT	p.G117G	CECR1_uc010gqu.1_Silent_p.G117G|CECR1_uc011agi.1_Silent_p.G75G|CECR1_uc011agj.1_Silent_p.G75G	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	117					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				TAGTCACGATGCCAATGTCAT	0.552			NA											5	79					0	0	0.000602	0	0
EFCAB6	64800	broad.mit.edu	37	22	43986047	43986047	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr22:43986047T>G	uc003bdy.1	-	24	3154	c.2939A>C	c.(2938-2940)AAA>ACA	p.K980T	EFCAB6_uc003bdz.1_Missense_Mutation_p.K828T|EFCAB6_uc010gzi.1_Missense_Mutation_p.K828T|EFCAB6_uc010gzj.1_Missense_Mutation_p.K206T	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	980	EF-hand 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GTAGTTGGTTTTGGATTGATC	0.428			NA											3	97					0	0	0.009096	0	0
MOV10L1	54456	broad.mit.edu	37	22	50547205	50547205	+	Silent	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr22:50547205A>T	uc003bjj.2	+	5	758	c.675A>T	c.(673-675)GCA>GCT	p.A225A	MOV10L1_uc003bjk.3_Silent_p.A225A|MOV10L1_uc011arp.1_Silent_p.A205A	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	225					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGGTCAATGCAGTGGTGGTGG	0.478			NA											25	67					0	0	0.003954	0	0
PBRM1	55193	broad.mit.edu	37	3	52643704	52643704	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr3:52643704A>T	uc003des.2	-	16	2204	c.2192T>A	c.(2191-2193)ATG>AAG	p.M731K	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.M731K|PBRM1_uc003der.2_Missense_Mutation_p.M699K|PBRM1_uc003det.2_Missense_Mutation_p.M746K|PBRM1_uc003deu.2_Missense_Mutation_p.M746K|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.M731K|PBRM1_uc010hmk.1_Missense_Mutation_p.M731K|PBRM1_uc003dey.2_Missense_Mutation_p.M731K|PBRM1_uc003dez.1_Missense_Mutation_p.M731K|PBRM1_uc003dfb.1_Missense_Mutation_p.M644K|PBRM1_uc003dfa.1_Missense_Mutation_p.M77K|PBRM1_uc003dfc.2_Missense_Mutation_p.M98K	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	731	Bromo 5.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATTATTAAACATCATGACAAA	0.408			NA	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								6	89					0	0	0.001984	0	0
CNTN3	5067	broad.mit.edu	37	3	74414733	74414733	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr3:74414733G>C	uc003dpm.1	-	8	1147	c.1067C>G	c.(1066-1068)GCA>GGA	p.A356G		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	356	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CACCAGGGCTGCTCCATTTTT	0.483			NA											123	145					0	0	0.01441	0	0
MYH15	22989	broad.mit.edu	37	3	108117506	108117506	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr3:108117506C>G	uc003dxa.1	-	36	5228	c.5171G>C	c.(5170-5172)AGA>ACA	p.R1724T		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1724	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AAGATTGATTCTTTCTGTTGC	0.527			NA											79	84					0	0	0.01441	0	0
LRRC58	116064	broad.mit.edu	37	3	120054769	120054769	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr3:120054769T>C	uc003edr.2	-	2	628	c.532A>G	c.(532-534)ATT>GTT	p.I178V		NM_001099678	NP_001093148	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	178	LRR 6.										0				GBM - Glioblastoma multiforme(114;0.147)		ATTTCTTTAATGAAATTTCCT	0.318			NA											28	27					0	0	0.005443	0	0
SIAH2	6478	broad.mit.edu	37	3	150460021	150460021	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr3:150460021G>A	uc003eyi.2	-	2	1509	c.882C>T	c.(880-882)AGC>AGT	p.S294S		NM_005067	NP_005058	O43255	SIAH2_HUMAN	seven in absentia homolog 2	294	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CAAGGCAGTCGCTGTTCATGA	0.498			NA											25	20					0	0	0.00333	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389175	1389175	+	Silent	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:1389175C>T	uc003gdf.2	+	1	3836	c.876C>T	c.(874-876)CTC>CTT	p.L292L		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	292					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCCGCCTGCTCACACGTGCCC	0.687			NA											100	232					0	0	0.01441	0	0
WHSC1	7468	broad.mit.edu	37	4	1952804	1952804	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:1952804G>T	uc003gdz.3	+	10	2063	c.1887G>T	c.(1885-1887)TCG>TCT	p.S629S	WHSC1_uc003geb.3_Silent_p.S629S|WHSC1_uc003gec.3_Silent_p.S629S|WHSC1_uc003ged.3_Silent_p.S629S|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_5'UTR|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_5'Flank	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	629					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TCTAGGTCTCGGACAGCCCGG	0.587			NA	T	IGH@	MM								17	53					1.15088e-07	1.46111e-07	0.004007	1	0
SLC2A9	56606	broad.mit.edu	37	4	9998467	9998467	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:9998467T>C	uc003gmc.2	-	3	409	c.348A>G	c.(346-348)ATA>ATG	p.I116M	SLC2A9_uc003gmd.2_Missense_Mutation_p.I87M	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	116	Helical; Name=2; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CGATGGCGAATATGGACACAG	0.498			NA											14	43					0	0	0.006122	0	0
LAP3	51056	broad.mit.edu	37	4	17590484	17590484	+	Silent	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:17590484C>T	uc003gph.1	+	7	909	c.747C>T	c.(745-747)CTC>CTT	p.L249L		NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	249					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						GATCATTCCTCAGTGTGGCCA	0.443			NA											30	80					0	0	0.010818	0	0
YIPF7	285525	broad.mit.edu	37	4	44638039	44638039	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:44638039C>A	uc010ifx.1	-	3	269	c.252G>T	c.(250-252)TCG>TCT	p.S84S	YIPF7_uc010ify.1_Silent_p.S84S	NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	84						endoplasmic reticulum membrane|integral to membrane					0						CTGCGTAACCCGATGACATGA	0.413			NA											12	41					0.000151284	0.0001767	0.001855	1	0
CWH43	80157	broad.mit.edu	37	4	49005982	49005982	+	Missense_Mutation	SNP	G	G	T	rs139364544		TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:49005982G>T	uc003gyv.2	+	7	1215	c.1033G>T	c.(1033-1035)GCT>TCT	p.A345S	CWH43_uc011bzl.1_Missense_Mutation_p.A318S	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	345					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						AGGTGTCTACGCTAGAGAAAG	0.393			NA											9	23					0.000442599	0.000500926	0.006214	1	0
KDR	3791	broad.mit.edu	37	4	55981449	55981449	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:55981449G>T	uc003has.2	-	4	790	c.488C>A	c.(487-489)GCA>GAA	p.A163E	KDR_uc003hat.1_Missense_Mutation_p.A163E|KDR_uc011bzx.1_Missense_Mutation_p.A163E	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	163	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GCAACTTACTGCACAAAGTGA	0.358			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			11	27					6.40141e-05	7.50688e-05	0.010729	1	0
NPFFR2	10886	broad.mit.edu	37	4	73012884	73012884	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:73012884C>A	uc003hgg.2	+	4	1022	c.924C>A	c.(922-924)TGC>TGA	p.C308*	NPFFR2_uc010iig.1_Nonsense_Mutation_p.C90*|NPFFR2_uc003hgi.2_Nonsense_Mutation_p.C209*|NPFFR2_uc003hgh.2_Nonsense_Mutation_p.C206*|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	308	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TCTACTGGTGCCGGGAAGACT	0.458			NA											20	64					8.00594e-06	9.74056e-06	0.007413	1	0
FRAS1	80144	broad.mit.edu	37	4	79432632	79432632	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:79432632G>T	uc003hlb.2	+	64	10425	c.9985G>T	c.(9985-9987)GAT>TAT	p.D3329Y	FRAS1_uc003hlc.1_Missense_Mutation_p.D331Y	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3324	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GAAATACCTGGATGTCAAACA	0.512			NA											10	20					2.17888e-05	2.60751e-05	0.006214	1	0
USP38	84640	broad.mit.edu	37	4	144124648	144124648	+	Silent	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:144124648T>C	uc003ijb.2	+	5	1672	c.1138T>C	c.(1138-1140)TTG>CTG	p.L380L	USP38_uc003ija.3_Silent_p.L380L|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	380					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					ATTAACAGAATTGATACACTG	0.333			NA											32	63					0	0	0.013726	0	0
RXFP1	59350	broad.mit.edu	37	4	159573154	159573154	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:159573154C>A	uc003ipz.2	+	18	2303	c.2221C>A	c.(2221-2223)CCC>ACC	p.P741T	RXFP1_uc011cja.1_Missense_Mutation_p.P636T|RXFP1_uc010iqo.2_Missense_Mutation_p.P693T|RXFP1_uc011cjb.1_Missense_Mutation_p.P639T|RXFP1_uc010iqk.2_Missense_Mutation_p.P609T|RXFP1_uc011cjc.1_Missense_Mutation_p.P660T|RXFP1_uc011cjd.1_Missense_Mutation_p.P660T|RXFP1_uc010iql.2_Missense_Mutation_p.P585T|RXFP1_uc011cje.1_Missense_Mutation_p.P768T|RXFP1_uc010iqm.2_Missense_Mutation_p.P708T|RXFP1_uc011cjf.1_Missense_Mutation_p.P610T|RXFP1_uc010iqn.2_Missense_Mutation_p.P686T	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	741	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TTTCACATACCCCTGTGAAAT	0.443			NA											15	55					1.3612e-06	1.69137e-06	0.003163	1	0
DDX60	55601	broad.mit.edu	37	4	169190053	169190053	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:169190053G>A	uc003irp.2	-	20	3030	c.2738C>T	c.(2737-2739)CCC>CTC	p.P913L		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	913	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AGCCAAAAAGGGACATCGGAT	0.358			NA											29	81					0	0	0.003755	0	0
PALLD	23022	broad.mit.edu	37	4	169611777	169611777	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:169611777G>A	uc011cjx.1	+	7	1570	c.1359G>A	c.(1357-1359)GCG>GCA	p.A453A	PALLD_uc003iru.2_Silent_p.A453A|PALLD_uc003irv.2_Silent_p.A71A	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	453	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CAGCCGTGGCGGAAGGCCAGG	0.502	Esophageal Squamous(109;1482 1532 18347 40239 51172)		NA							Pancreatic_Cancer_Familial_Clustering_of				56	146					0	0	0.01441	0	0
FAT1	2195	broad.mit.edu	37	4	187628565	187628565	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr4:187628565C>T	uc003izf.2	-	2	2605	c.2417G>A	c.(2416-2418)CGT>CAT	p.R806H	FAT1_uc010iso.1_Missense_Mutation_p.R806H	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	806	Extracellular (Potential).|Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGTAGAAGACGCCACGCAGC	0.443	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			55	153					0	0	0.01441	0	0
FBXL7	23194	broad.mit.edu	37	5	15928306	15928306	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:15928306C>A	uc003jfn.1	+	3	916	c.435C>A	c.(433-435)TAC>TAA	p.Y145*		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	145	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						GCCGCTGGTACAACCTGGCCT	0.672			NA											5	11					0.00116845	0.00130723	0.001168	1	0
UGT3A1	133688	broad.mit.edu	37	5	35957471	35957471	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:35957471C>A	uc003jjv.1	-	5	1051	c.894G>T	c.(892-894)GTG>GTT	p.V298V	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Silent_p.V298V|UGT3A1_uc011cor.1_Silent_p.V264V	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	298	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGCCAAAGGCCACAAGGACAA	0.488			NA											16	40					6.94344e-10	9.38651e-10	0.006122	1	0
MAST4	375449	broad.mit.edu	37	5	66460901	66460901	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:66460901G>T	uc003jut.1	+	28	5395	c.5327G>T	c.(5326-5328)AGG>ATG	p.R1776M	MAST4_uc003juw.2_Missense_Mutation_p.R1704M|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1968						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TCCCCCTCAAGGGAGAAGCCA	0.647			NA											3	10					0.004672	0.00507146	0.004672	1	0
PIK3R1	5295	broad.mit.edu	37	5	67589621	67589621	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:67589621G>T	uc003jva.2	+	11	1944	c.1384G>T	c.(1384-1386)GAA>TAA	p.E462*	PIK3R1_uc003jvb.2_Nonsense_Mutation_p.E462*|PIK3R1_uc003jvc.2_Nonsense_Mutation_p.E162*|PIK3R1_uc003jvd.2_Nonsense_Mutation_p.E192*|PIK3R1_uc003jve.2_Nonsense_Mutation_p.E141*|PIK3R1_uc011crb.1_Nonsense_Mutation_p.E132*	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	462					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.T454_D464del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAAAAGTCGAGAATATGATAG	0.284			NA	Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			26	58					3.6726e-16	5.95778e-16	0.003954	1	0
MAP1B	4131	broad.mit.edu	37	5	71490202	71490202	+	Silent	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:71490202C>T	uc003kbw.3	+	5	1261	c.1020C>T	c.(1018-1020)ACC>ACT	p.T340T	MAP1B_uc010iyw.1_Silent_p.T357T|MAP1B_uc010iyx.1_Silent_p.T214T|MAP1B_uc010iyy.1_Silent_p.T214T	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	340						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGGGCTCCACCACAAATAGTG	0.448	Melanoma(17;367 822 11631 31730 47712)		NA											20	45					0	0	0.008871	0	0
TMEM171	134285	broad.mit.edu	37	5	72419665	72419665	+	Silent	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:72419665C>T	uc003kcm.2	+	2	669	c.465C>T	c.(463-465)CCC>CCT	p.P155P	TMEM171_uc003kcn.3_Silent_p.P155P	NM_173490	NP_775761	Q8WVE6	TM171_HUMAN	transmembrane protein 171 isoform 1	155						integral to membrane					0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		ACTCAGAGCCCCGGATGTGTG	0.562	NSCLC(112;638 2280 27369 30736)		NA											46	119					0	0	0.01441	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475340	140475340	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:140475340G>T	uc003lil.2	+	1	1104	c.966G>T	c.(964-966)CAG>CAT	p.Q322H	PCDHB2_uc003lim.1_Translation_Start_Site	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	322	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAAATATTCAGGCGACAGATG	0.418			NA											33	67					4.74835e-14	7.4947e-14	0.010818	1	0
PCDHB17	54661	broad.mit.edu	37	5	140537229	140537229	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:140537229G>T	uc003lis.2	+	1	1650	c.1650G>T	c.(1648-1650)CTG>CTT	p.L550L		NR_001280				SubName: Full=Protocadherin-psi1;												0						TGCGCGTGCTGGTGTGCTGGA	0.711			NA											35	47					2.09667e-21	3.62264e-21	0.003755	1	0
PCDHB12	56124	broad.mit.edu	37	5	140589383	140589383	+	Missense_Mutation	SNP	A	A	T	rs147813756		TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:140589383A>T	uc003liz.2	+	1	1093	c.904A>T	c.(904-906)ACT>TCT	p.T302S	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	302	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGACATTACTTTAACAGC	0.368			NA											38	83					0	0	0.003755	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736276	140736276	+	Silent	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:140736276C>G	uc003ljq.1	+	1	1509	c.1509C>G	c.(1507-1509)TCC>TCG	p.S503S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.S503S	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	503	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTGTCCTCCTATGTCTCCA	0.507			NA											56	128					0	0	0.01441	0	0
DCTN4	51164	broad.mit.edu	37	5	150121678	150121678	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:150121678G>T	uc003lsv.2	-	4	529	c.427C>A	c.(427-429)CGG>AGG	p.R143R	DCTN4_uc003lsu.2_Silent_p.R86R|DCTN4_uc010jhi.2_Silent_p.R143R|DCTN4_uc010jhj.2_Intron|DCTN4_uc011dck.1_Silent_p.R86R	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	143						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTACTTACCCGTTGTGTGTGA	0.338			NA											107	207					2.38168e-41	4.51592e-41	0.01441	1	0
FAM71B	153745	broad.mit.edu	37	5	156592744	156592744	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr5:156592744T>C	uc003lwn.2	-	1	536	c.436A>G	c.(436-438)ACT>GCT	p.T146A		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	146						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTACGGCCAGTGGCGAGTTTC	0.493			NA											37	74					0	0	0.003755	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7988040	7988040	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr6:7988040T>A	uc003mxx.3	+	1	1706	c.1271T>A	c.(1270-1272)TTC>TAC	p.F424Y	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						CGCCCAGGCTTCTACGCTGAA	0.473			NA											28	111					0	0	0.007291	0	0
JARID2	3720	broad.mit.edu	37	6	15452366	15452366	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr6:15452366G>T	uc003nbj.2	+	4	697	c.453G>T	c.(451-453)AAG>AAT	p.K151N	JARID2_uc011diu.1_Intron|JARID2_uc011div.1_5'UTR|JARID2_uc011diw.1_Missense_Mutation_p.K113N	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	151					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CTAAAAGGAAGCCTAAGACAG	0.483			NA											37	85					1.04594e-18	1.73531e-18	0.00623	1	0
FAM65B	9750	broad.mit.edu	37	6	24848310	24848310	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr6:24848310C>T	uc003neo.1	-	12	1196	c.1020G>A	c.(1018-1020)ATG>ATA	p.M340I	FAM65B_uc011djs.1_Missense_Mutation_p.M369I|FAM65B_uc011dju.1_Missense_Mutation_p.M374I|FAM65B_uc003nep.2_Missense_Mutation_p.M340I|FAM65B_uc011djt.1_Missense_Mutation_p.M340I	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	340					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						TGTACATGGACATTCTCCTCT	0.527			NA											16	47					0	0	0.003163	0	0
IBTK	25998	broad.mit.edu	37	6	82936912	82936912	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr6:82936912G>T	uc003pjl.1	-	5	1178	c.651C>A	c.(649-651)TGC>TGA	p.C217*	IBTK_uc011dyv.1_Nonsense_Mutation_p.C217*|IBTK_uc011dyw.1_Nonsense_Mutation_p.C217*|IBTK_uc010kbi.1_5'UTR|IBTK_uc003pjm.2_Nonsense_Mutation_p.C217*	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	217	RCC1 2.				negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CAATTACCAAGCATGTCTGTT	0.358			NA											22	62					7.87624e-14	1.22987e-13	0.00278	1	0
CGA	1081	broad.mit.edu	37	6	87795485	87795485	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr6:87795485G>T	uc003plj.1	-	4	441	c.340C>A	c.(340-342)CAC>AAC	p.H114N		NM_000735	NP_000726	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	114					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			ovary(1)	1		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		TAAGATTTGTGATAATAACAA	0.368			NA											9	14					2.17888e-05	2.60751e-05	0.006214	1	0
MAP3K4	4216	broad.mit.edu	37	6	161491814	161491814	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr6:161491814C>T	uc003qtn.2	+	4	2024	c.1882C>T	c.(1882-1884)CAT>TAT	p.H628Y	MAP3K4_uc010kkc.1_Missense_Mutation_p.H628Y|MAP3K4_uc003qto.2_Missense_Mutation_p.H628Y|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.H81Y	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	628					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GAATGTCATACATGAGTGTCT	0.448			NA											10	23					0	0	0.008291	0	0
SNX10	29887	broad.mit.edu	37	7	26400636	26400636	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:26400636G>T	uc003sxx.2	+	3	281	c.66G>T	c.(64-66)AAG>AAT	p.K22N	SNX10_uc011jzg.1_Missense_Mutation_p.K45N|SNX10_uc010kuu.2_Missense_Mutation_p.K22N|SNX10_uc010kuv.2_Missense_Mutation_p.K18N	NM_013322	NP_037454	Q9Y5X0	SNX10_HUMAN	sorting nexin 10	22	PX.				cell communication|endosome organization|protein transport	extrinsic to endosome membrane	1-phosphatidylinositol binding				0						GGATTCAGAAGGAGGACTTCT	0.358			NA											13	65					2.32078e-09	3.10857e-09	0.003163	1	0
DPY19L2P1	554236	broad.mit.edu	37	7	35144364	35144364	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:35144364G>T	uc003teq.1	-	18	1851	c.744C>A	c.(742-744)CAC>CAA	p.H248Q	DPY19L2P1_uc003tep.1_RNA|DPY19L2P1_uc010kwz.1_RNA					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						ACTGCAATGTGTGAAAAGCCA	0.303			NA											12	22					5.16669e-11	7.28827e-11	0.010729	1	0
POU6F2	11281	broad.mit.edu	37	7	39379533	39379533	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:39379533G>A	uc003thb.1	+	5	846	c.804G>A	c.(802-804)CAG>CAA	p.Q268Q	POU6F2_uc010kxo.2_Silent_p.Q260Q	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	268	Pro-rich.|Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						caacccagcagagctccagcc	0.264			NA											14	35					0	0	0.00245	0	0
ZNF716	441234	broad.mit.edu	37	7	57528793	57528793	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:57528793G>T	uc011kdi.1	+	4	738	c.626G>T	c.(625-627)AGG>ATG	p.R209M		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						ATTCATACTAGGGAGAAGTCT	0.353			NA											4	17					0.00024832	0.000284351	0.009096	1	0
ZNF107	51427	broad.mit.edu	37	7	64167704	64167704	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:64167704C>T	uc003ttd.2	+	7	1808	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L	ZNF107_uc003tte.2_Missense_Mutation_p.S341L	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	341	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AACCAGTTCTCAACTCTTACT	0.343			NA											17	24					0	0	0.00499	0	0
SEMA3D	223117	broad.mit.edu	37	7	84666213	84666213	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:84666213G>C	uc003uic.2	-	10	1223	c.1183C>G	c.(1183-1185)CCT>GCT	p.P395A	SEMA3D_uc010led.2_Missense_Mutation_p.P395A|SEMA3D_uc003uib.2_Missense_Mutation_p.P34A	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	395	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						ACTGTACCAGGCCGTGGATAA	0.363	Ovarian(63;442 1191 17318 29975 31528)		NA											16	51					0	0	0.004007	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95657604	95657604	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:95657604C>G	uc003uoc.3	+	11	1415	c.1138C>G	c.(1138-1140)CGG>GGG	p.R380G	DYNC1I1_uc003uod.3_Missense_Mutation_p.R363G|DYNC1I1_uc003uob.2_Missense_Mutation_p.R343G|DYNC1I1_uc003uoe.3_Missense_Mutation_p.R360G|DYNC1I1_uc010lfl.2_Missense_Mutation_p.R369G	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	380					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCCAGTGCAGCGGACACCCTT	0.517			NA											45	82					0	0	0.013114	0	0
LAMB1	3912	broad.mit.edu	37	7	107600230	107600230	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:107600230G>T	uc003vew.2	-	19	2699	c.2364C>A	c.(2362-2364)AAC>AAA	p.N788K	LAMB1_uc003vev.2_Missense_Mutation_p.N812K|LAMB1_uc003vex.2_Missense_Mutation_p.N788K	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	788	Laminin EGF-like 6.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGGCCTCCGTTGGGATCAC	0.562			NA											11	20					1.05317e-09	1.41717e-09	0.00245	1	0
EPHB6	2051	broad.mit.edu	37	7	142562228	142562228	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:142562228G>A	uc011kst.1	+	7	1457	c.670G>A	c.(670-672)GCT>ACT	p.A224T	EPHB6_uc011ksu.1_Missense_Mutation_p.A224T|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_Intron|EPHB6_uc003wbu.2_5'UTR|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	224	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GGCCCTGGTCGCTGTCAGGCT	0.652			NA											6	142					0	0	0.001984	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144062360	144062360	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:144062360G>T	uc003wel.2	+	2	2716	c.2598G>T	c.(2596-2598)CGG>CGT	p.R866R	ARHGEF5_uc003wek.2_Silent_p.R866R|ARHGEF5_uc003wem.2_5'Flank	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	866					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					GGAGCACTCGGGGAGGACATA	0.612			NA											13	122					6.72482e-11	9.39545e-11	0.003163	1	0
KCNH2	3757	broad.mit.edu	37	7	150644119	150644119	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:150644119T>C	uc003wic.2	-	14	3189	c.3176A>G	c.(3175-3177)GAC>GGC	p.D1059G	KCNH2_uc003wib.2_Missense_Mutation_p.D719G|KCNH2_uc011kux.1_Missense_Mutation_p.D963G	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	1059	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	AGTGGCCATGTCTGCACTCAG	0.597	GBM(137;110 1844 13671 20123 45161)		NA											27	47					0	0	0.003954	0	0
MYOM2	9172	broad.mit.edu	37	8	2021510	2021510	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:2021510G>T	uc003wpx.3	+	10	1188	c.1050G>T	c.(1048-1050)GAG>GAT	p.E350D	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	350	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AGGACGACGAGGGCCTGTACA	0.602			NA											19	61					3.32936e-07	4.1904e-07	0.006122	1	0
MYOM2	9172	broad.mit.edu	37	8	2044147	2044147	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:2044147T>A	uc003wpx.3	+	18	2324	c.2186T>A	c.(2185-2187)CTC>CAC	p.L729H	MYOM2_uc011kwi.1_Missense_Mutation_p.L154H	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	729	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCCATGACCCTCGGCTGGAAG	0.572			NA											25	76					0	0	0.003954	0	0
CSMD1	64478	broad.mit.edu	37	8	4851865	4851865	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:4851865G>A	uc011kwk.1	-	1	464	c.74C>T	c.(73-75)ACT>ATT	p.T25I		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	25						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTTCGCTGCAGTGAGGAGCCT	0.657			NA											10	33					0	0	0.008291	0	0
POLR3D	661	broad.mit.edu	37	8	22107690	22107690	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:22107690G>T	uc003xbl.2	+	8	1107	c.1024G>T	c.(1024-1026)GGC>TGC	p.G342C	POLR3D_uc003xbm.2_Missense_Mutation_p.G342C|POLR3D_uc011kze.1_RNA	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	342					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		ACTCCTCTTGGGCAAGGTGAC	0.567			NA											13	40					3.27435e-08	4.28749e-08	0.00245	1	0
KCNU1	157855	broad.mit.edu	37	8	36703176	36703176	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:36703176G>T	uc010lvw.2	+	17	1869	c.1782G>T	c.(1780-1782)AAG>AAT	p.K594N	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	594	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AAACTCCAAAGGACGTCAGAA	0.408			NA											10	45					2.52707e-12	3.68952e-12	0.006214	1	0
SGK196	84197	broad.mit.edu	37	8	42977285	42977285	+	Silent	SNP	A	A	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:42977285A>G	uc003xpw.2	+	5	577	c.318A>G	c.(316-318)GCA>GCG	p.A106A		NM_032237	NP_115613	Q9H5K3	SG196_HUMAN	protein kinase-like protein SgK196	106	Protein kinase.					integral to membrane	ATP binding|protein kinase activity				0						ACAAAGTTGCACTCTCACAGC	0.473			NA											51	94					0	0	0.01441	0	0
PRKDC	5591	broad.mit.edu	37	8	48767902	48767902	+	Silent	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:48767902T>C	uc003xqi.2	-	51	6699	c.6642A>G	c.(6640-6642)CGA>CGG	p.R2214R	PRKDC_uc003xqj.2_Silent_p.R2214R|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2214					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AATTAAGCAATCGATTTGCTA	0.368	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					7	10					0	0	0.00308	0	0
SNTG1	54212	broad.mit.edu	37	8	51664632	51664632	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:51664632T>A	uc010lxy.1	+	19	1727	c.1356T>A	c.(1354-1356)TTT>TTA	p.F452L	SNTG1_uc003xqs.1_Missense_Mutation_p.F452L|SNTG1_uc010lxz.1_Intron|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	452					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AAATCAAATTTTTGTTTCAGA	0.348			NA											47	123					0	0	0.01441	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75932314	75932314	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:75932314G>T	uc003yan.2	+	12	1619	c.1244G>T	c.(1243-1245)AGA>ATA	p.R415I	CRISPLD1_uc011lfk.1_Missense_Mutation_p.R227I|CRISPLD1_uc011lfl.1_Missense_Mutation_p.R227I	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	415	LCCL 2.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			CATTGCCCAAGGTAAACCAGT	0.408			NA											12	37					2.61681e-11	3.72737e-11	0.00245	1	0
POP1	10940	broad.mit.edu	37	8	99142345	99142345	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:99142345C>T	uc003yij.3	+	5	726	c.626C>T	c.(625-627)GCC>GTC	p.A209V	POP1_uc011lgv.1_Missense_Mutation_p.A209V|POP1_uc003yik.2_Missense_Mutation_p.A209V	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	209					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			ATCTGGCACGCCAAGCGGTTT	0.488			NA											17	53					0	0	0.007413	0	0
RGS22	26166	broad.mit.edu	37	8	101065202	101065202	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:101065202G>A	uc003yjb.1	-	10	1712	c.1517C>T	c.(1516-1518)GCA>GTA	p.A506V	RGS22_uc003yja.1_Missense_Mutation_p.A325V|RGS22_uc003yjc.1_Missense_Mutation_p.A494V|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	506					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			GAATCTTGGTGCCCTGTTTAT	0.368			NA											7	160					0	0	0.001984	0	0
RIMS2	9699	broad.mit.edu	37	8	104930687	104930687	+	Silent	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:104930687T>C	uc003yls.2	+	7	1630	c.1389T>C	c.(1387-1389)CCT>CCC	p.P463P	RIMS2_uc003ylp.2_Silent_p.P685P|RIMS2_uc003ylw.2_Silent_p.P493P|RIMS2_uc003ylq.2_Silent_p.P493P|RIMS2_uc003ylr.2_Silent_p.P540P|RIMS2_uc003ylt.2_Silent_p.P86P|RIMS2_uc003ylu.1_Silent_p.P76P|RIMS2_uc003ylv.1_Silent_p.P76P	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	763					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CGCGAATACCTGATAGCACAC	0.294			NA								HNSCC(12;0.0054)			3	87					0	0	0.009096	0	0
KCNV1	27012	broad.mit.edu	37	8	110986332	110986332	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:110986332G>T	uc003ynr.3	-	1	628	c.286C>A	c.(286-288)CCC>ACC	p.P96T	KCNV1_uc010mcw.2_Missense_Mutation_p.P96T	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	96	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TTGTCCACGGGGTTGGCATCG	0.672			NA											6	21					0.000157383	0.000181644	0.00308	1	0
FER1L6	654463	broad.mit.edu	37	8	125094556	125094556	+	Silent	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:125094556A>T	uc003yqw.2	+	33	4454	c.4248A>T	c.(4246-4248)CCA>CCT	p.P1416P	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1416	C2 5.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCACATTCCCAAAAGAGTCCC	0.478			NA											53	107					0	0	0.01441	0	0
FAM135B	51059	broad.mit.edu	37	8	139263221	139263221	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:139263221G>T	uc003yuy.2	-	6	576	c.405C>A	c.(403-405)AGC>AGA	p.S135R	FAM135B_uc003yux.2_Missense_Mutation_p.S36R|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	135										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAAGCGTTCGGCTGCTGACCA	0.592			NA								HNSCC(54;0.14)			39	113					6.2361e-21	1.06488e-20	0.007835	1	0
FLJ43860	389690	broad.mit.edu	37	8	142505489	142505490	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:142505489_142505490GG>TT	uc003ywi.2	-	3	437_438	c.356_357CC>AA	c.(355-357)TCC>TAA	p.S119*	FLJ43860_uc011ljs.1_5'Flank|FLJ43860_uc010meu.1_5'Flank	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	119							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCAGCTTGGGGGAGCCATGAGC	0.559			NA											28	71					0	0	0.004672	0	0
ARC	23237	broad.mit.edu	37	8	143695607	143695608	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:143695607_143695608CC>AA	uc003ywn.1	-	1	226_227	c.25_26GG>TT	c.(25-27)GGC>TTC	p.G9F		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	9					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				GTGGAGCCCGCCGCTGGTCCGG	0.738			NA											7	14					0	0	0.004672	0	0
SLURP1	57152	broad.mit.edu	37	8	143822670	143822670	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:143822670A>G	uc003ywy.2	-	3	229	c.203T>C	c.(202-204)GTG>GCG	p.V68A		NM_020427	NP_065160	P55000	SLUR1_HUMAN	ARS component B precursor	68	UPAR/Ly6.				cell activation|cell adhesion	extracellular space	cytokine activity				0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCGGGTCACCACGGGGCTCTG	0.672			NA											11	15					0	0	0.010729	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996498	143996498	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr8:143996498C>T	uc003yxk.1	-	3	562	c.559G>A	c.(559-561)GAC>AAC	p.D187N		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	187					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGCTGGACGTCCAGGGTCAGG	0.642			NA							Familial_Hyperaldosteronism_type_I				6	23					0	0	0.001168	0	0
IFNA6	3443	broad.mit.edu	37	9	21350395	21350396	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:21350395_21350396CC>AA	uc011lni.1	-	1	491_492	c.491_492GG>TT	c.(490-492)TGG>TTT	p.W164F		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	164					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGACAACCTCCCAGGCACAAGG	0.455			NA											95	292					0	0	0.004672	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627205	43627205	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:43627205C>A	uc011lrb.1	-	4	1511	c.1482G>T	c.(1480-1482)GAG>GAT	p.E494D		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	494						integral to membrane					0						GGGCCTGAGCCTCGGCCTGAG	0.542			NA											199	502					3.81497e-87	7.32875e-87	0.01441	1	0
XPA	7507	broad.mit.edu	37	9	100455996	100455996	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:100455996C>T	uc004axr.3	-	2	335	c.218G>A	c.(217-219)GGA>GAA	p.G73E	XPA_uc004axs.3_RNA	NM_000380	NP_000371	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A	73	Interaction with CEP164 and required for UV resistance.				nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity			breast(1)	1		Acute lymphoblastic leukemia(62;0.158)				AATGAAGCCTCCTCCTGTGTC	0.353			NA	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				15	57					0	0	0.003163	0	0
SVEP1	79987	broad.mit.edu	37	9	113173762	113173762	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:113173762G>T	uc010mtz.2	-	37	6566	c.6229C>A	c.(6229-6231)CGT>AGT	p.R2077S	SVEP1_uc010mty.2_Missense_Mutation_p.R3S	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2077	Sushi 11.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GCTATACAACGGGGCATGTCT	0.478			NA											15	22					0.000308642	0.000350675	0.003163	1	0
KIF12	113220	broad.mit.edu	37	9	116859704	116859704	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:116859704G>A	uc004bif.2	-	4	347	c.109C>T	c.(109-111)CTG>TTG	p.L37L	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	170	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						CCCAGGCTCAGCAAGTCCCGA	0.627			NA											12	40					0	0	0.001855	0	0
TNC	3371	broad.mit.edu	37	9	117810558	117810558	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:117810558C>G	uc004bjj.3	-	16	5195	c.4833G>C	c.(4831-4833)TTG>TTC	p.L1611F	TNC_uc010mvf.2_Intron	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1611	Fibronectin type-III 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TCTCAGCCCTCAAGGGCTTGG	0.493			NA											5	194					0	0	0.001168	0	0
C5	727	broad.mit.edu	37	9	123783854	123783854	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:123783854C>A	uc004bkv.2	-	11	1265	c.1235G>T	c.(1234-1236)CGT>CTT	p.R412L	C5_uc010mvm.1_Missense_Mutation_p.R412L|C5_uc010mvn.1_Missense_Mutation_p.R412L	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	412					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	ATCATCAACACGTGTTACACT	0.433			NA											19	59					1.96292e-10	2.69095e-10	0.010504	1	0
ST6GALNAC6	30815	broad.mit.edu	37	9	130649020	130649020	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr9:130649020T>C	uc004bso.1	-	7	979	c.860A>G	c.(859-861)AAG>AGG	p.K287R	ST6GALNAC6_uc004bsn.1_Missense_Mutation_p.K253R|ST6GALNAC6_uc011man.1_Missense_Mutation_p.K87R|ST6GALNAC6_uc004bsp.1_Missense_Mutation_p.R286G|ST6GALNAC6_uc004bsq.1_Missense_Mutation_p.K253R|ST6GALNAC6_uc004bsr.2_Missense_Mutation_p.K253R|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	287	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0						GTCCGGCCCCTTGGGCTCGTA	0.463			NA											3	74					0	0	0.009096	0	0
MXRA5	25878	broad.mit.edu	37	X	3248300	3248300	+	Silent	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:3248300G>T	uc004crg.3	-	4	625	c.468C>A	c.(466-468)CTC>CTA	p.L156L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	156	LRR 5.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTTCCAAATGGAGTAGCCTCA	0.478			NA											17	38					4.14922e-12	5.99788e-12	0.004007	1	0
WWC3	55841	broad.mit.edu	37	X	10093091	10093091	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:10093091C>A	uc004csx.3	+	14	2052	c.1854C>A	c.(1852-1854)CTC>CTA	p.L618L	WWC3_uc010nds.2_Silent_p.L282L|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	618	C2.									ovary(4)	4						AGTGTCTCCTCGTGCACGTGC	0.622			NA											8	17					2.74318e-10	3.74303e-10	0.006214	1	0
DMD	1756	broad.mit.edu	37	X	31645941	31645941	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:31645941C>G	uc004dda.1	-	55	8310	c.8066G>C	c.(8065-8067)AGA>ACA	p.R2689T	DMD_uc004dcr.1_Missense_Mutation_p.R229T|DMD_uc004dcs.1_Missense_Mutation_p.R229T|DMD_uc004dct.1_Missense_Mutation_p.R229T|DMD_uc004dcu.1_Missense_Mutation_p.R229T|DMD_uc004dcv.1_Missense_Mutation_p.R229T|DMD_uc004dcw.2_Missense_Mutation_p.R1345T|DMD_uc004dcx.2_Missense_Mutation_p.R1348T|DMD_uc004dcz.2_Missense_Mutation_p.R2566T|DMD_uc004dcy.1_Missense_Mutation_p.R2685T|DMD_uc004ddb.1_Missense_Mutation_p.R2681T	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2689	Spectrin 19.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGCAGTAATCTATGAGTTTC	0.453			NA											6	24					0	0	0.001984	0	0
FAM47C	442444	broad.mit.edu	37	X	37029325	37029325	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:37029325G>T	uc004ddl.1	+	1	2856	c.2842G>T	c.(2842-2844)GGG>TGG	p.G948W		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	948										ovary(3)	3						GCCTAAGTTGGGGAAAAAGCT	0.458			NA											60	118					4.83677e-39	9.11186e-39	0.01441	1	0
UBQLN2	29978	broad.mit.edu	37	X	56591819	56591819	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:56591819G>T	uc004dus.2	+	1	1748	c.1513G>T	c.(1513-1515)GTC>TTC	p.V505F	UBQLN2_uc011moq.1_Intron	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	505	5.|12 X 3 AA tandem repeats of P-X-X.					cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						AGGCCCTATAGTCCCTTTTAC	0.662	Esophageal Squamous(104;218 1492 6022 10838 28884)		NA											3	4					0.00909568	0.00972871	0.009096	1	0
SPIN4	139886	broad.mit.edu	37	X	62570685	62570685	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:62570685G>T	uc004dvf.2	-	1	534	c.14C>A	c.(13-15)ACC>AAC	p.T5N		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	5					gamete generation					ovary(1)|lung(1)	2						CGGAGGCACGGTTGGAGGAGA	0.512			NA											13	57					1.49906e-05	1.81629e-05	0.00245	1	0
EDA	1896	broad.mit.edu	37	X	69255353	69255353	+	Missense_Mutation	SNP	G	G	T	rs61747506		TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:69255353G>T	uc004dxs.2	+	8	1312	c.1070G>T	c.(1069-1071)CGG>CTG	p.R357L	EDA_uc004dxr.2_Missense_Mutation_p.R355L|EDA_uc011mpj.1_Missense_Mutation_p.R352L	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	357	Extracellular (Potential).		R -> P (in ED1).		cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						CTCAAGGCCCGGCAGAAGATC	0.582			NA											17	55					3.45872e-05	4.12223e-05	0.004007	1	0
KIF4A	24137	broad.mit.edu	37	X	69550032	69550032	+	Silent	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:69550032T>A	uc004dyg.2	+	9	1048	c.921T>A	c.(919-921)ACT>ACA	p.T307T	KIF4A_uc010nkw.2_Silent_p.T307T|KIF4A_uc004dyf.1_Silent_p.T307T	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	307	Kinesin-motor.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						ATAGCCATACTCTTATGATAG	0.378			NA											62	156					0	0	0.01441	0	0
KIF4A	24137	broad.mit.edu	37	X	69637839	69637839	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:69637839C>A	uc004dyg.2	+	29	3484	c.3357C>A	c.(3355-3357)AAC>AAA	p.N1119K	KIF4A_uc010nkw.2_Missense_Mutation_p.N1119K	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	1119	Globular.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						AGTGTCGGAACCGCCAGCAAG	0.542			NA											22	61					1.55795e-14	2.47239e-14	0.012319	1	0
DLG3	1741	broad.mit.edu	37	X	69670523	69670523	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:69670523A>T	uc004dyi.1	+	6	1203	c.875A>T	c.(874-876)GAG>GTG	p.E292V	DLG3_uc004dyj.1_5'Flank	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	292	PDZ 2.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					GTGAGGCACGAGGAAGCTGTG	0.557			NA											14	35					0	0	0.003163	0	0
ZMYM3	9203	broad.mit.edu	37	X	70464286	70464286	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:70464286G>T	uc004dzh.1	-	20	3233	c.3146C>A	c.(3145-3147)TCC>TAC	p.S1049Y	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.S1049Y|ZMYM3_uc004dzj.1_Missense_Mutation_p.S1037Y	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1049					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					GGAGTCCCGGGAGCAGCTTTC	0.537			NA											16	24					1.15088e-07	1.46111e-07	0.004007	1	0
ATP7A	538	broad.mit.edu	37	X	77289241	77289241	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:77289241G>C	uc004ecx.3	+	17	3593	c.3433G>C	c.(3433-3435)GCA>CCA	p.A1145P		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1145	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TATTAAAAATGCATCCCTGGT	0.373			NA											44	106					0	0	0.009718	0	0
TCEAL5	340543	broad.mit.edu	37	X	102529326	102529326	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:102529326C>A	uc004ejz.1	-	3	461	c.166G>T	c.(166-168)GAT>TAT	p.D56Y		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	56	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						tctccctcatcctctcgcttt	0.189			NA											26	91					6.32553e-13	9.5209e-13	0.004656	1	0
RAB9B	51209	broad.mit.edu	37	X	103080666	103080666	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:103080666C>A	uc004ell.1	-	3	334	c.49G>T	c.(49-51)GGA>TGA	p.G17*	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	17	GTP.				Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						TTCCCAACTCCACCATCACCC	0.433			NA											69	170					7.577e-32	1.36573e-31	0.01441	1	0
TEX13A	56157	broad.mit.edu	37	X	104463890	104463890	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:104463890G>T	uc004ema.2	-	5	1098	c.986C>A	c.(985-987)CCG>CAG	p.P329Q	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.R330S	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	329						intracellular	zinc ion binding			ovary(2)	2						CAGCTGAGGCGGAACTGGTGC	0.542			NA											26	60					6.12954e-19	1.02276e-18	0.004656	1	0
GUCY2F	2986	broad.mit.edu	37	X	108684589	108684589	+	Silent	SNP	C	C	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:108684589C>A	uc004eod.3	-	7	1968	c.1692G>T	c.(1690-1692)GCG>GCT	p.A564A	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	564	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CCTCATAAATCGCTATGTTGG	0.403			NA											88	172					3.7744e-50	7.20342e-50	0.01441	1	0
LONRF3	79836	broad.mit.edu	37	X	118109401	118109401	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:118109401C>T	uc004eqw.2	+	1	689	c.658C>T	c.(658-660)CCG>TCG	p.P220S	LONRF3_uc004eqx.2_Missense_Mutation_p.P220S|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_5'Flank	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	220					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						GCAGCAGCCGCCGCCGCCGCT	0.736			NA											7	12					0	0	0.00308	0	0
HTATSF1	27336	broad.mit.edu	37	X	135585093	135585093	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:135585093C>G	uc004ezw.2	+	6	1149	c.727C>G	c.(727-729)CAA>GAA	p.Q243E	HTATSF1_uc004ezx.2_Missense_Mutation_p.Q243E	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	243					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCTGTCTATGCAACAAAAGTT	0.338			NA											25	67					0	0	0.004656	0	0
GPR101	83550	broad.mit.edu	37	X	136112642	136112642	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:136112642C>G	uc011mwh.1	-	1	1192	c.1192G>C	c.(1192-1194)GCT>CCT	p.A398P		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	398	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					ATCACTTTAGCAGCTTTGCAC	0.552			NA											35	70					0	0	0.013726	0	0
GABRQ	55879	broad.mit.edu	37	X	151818269	151818269	+	Silent	SNP	T	T	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:151818269T>A	uc004ffp.1	+	6	695	c.675T>A	c.(673-675)ACT>ACA	p.T225T		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	225	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCACATGACTGAGGAGCTGC	0.478			NA											47	116					0	0	0.01441	0	0
PNMA3	29944	broad.mit.edu	37	X	152226785	152226785	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:152226785C>T	uc004fhc.2	+	2	1709	c.1373C>T	c.(1372-1374)CCC>CTC	p.P458L	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	458					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGCCATCCCAAGTCCAAG	0.532			NA											64	112					0	0	0.01441	0	0
SLC6A8	6535	broad.mit.edu	37	X	152958581	152958581	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:152958581G>T	uc004fib.3	+	5	1141	c.863G>T	c.(862-864)GGC>GTC	p.G288V	SLC6A8_uc004fic.3_Missense_Mutation_p.G288V|SLC6A8_uc011myx.1_Missense_Mutation_p.G173V|SLC6A8_uc010nuj.2_RNA	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	288	Helical; (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	GCCCTGGATGGCATCATTTAC	0.632			NA											9	18					0.00448238	0.00493908	0.004482	1	0
SRPK3	26576	broad.mit.edu	37	X	153048494	153048494	+	Silent	SNP	G	G	A			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:153048494G>A	uc004fil.2	+	7	701	c.669G>A	c.(667-669)GGG>GGA	p.G223G	SRPK3_uc004fik.2_Silent_p.G289G|SRPK3_uc010nul.2_Silent_p.G181G|SRPK3_uc004fin.2_Silent_p.G223G|SRPK3_uc004fim.2_Silent_p.G223G	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	223	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TGTGTGTGGGGGACGCTTACA	0.647	Esophageal Squamous(167;766 3400 32156)		NA											15	45					0	0	0.010504	0	0
KIAA1751	85452	broad.mit.edu	37	1	1919959	1919959	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr1:1919959delC	uc001aim.1	-	4	444	c.288delG	c.(286-288)GAGfs	p.E96fs	KIAA1751_uc009vkz.1_Frame_Shift_Del_p.E96fs|KIAA1751_uc001ain.1_Frame_Shift_Del_p.E96fs	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	96										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		ACCTCATCTTCTCAGTGAAAA	0.582			NA											20	69	---	---	---	---	NA	NA	NA	NA	NA
KRT6B	3854	broad.mit.edu	37	12	52845639	52845639	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:52845639delC	uc001sak.2	-	1	272	c.224delG	c.(223-225)GGCfs	p.G75fs		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	75	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		GGCACAGCTGCCCCCTCCAAT	0.647			NA											10	33	---	---	---	---	NA	NA	NA	NA	NA
MGAT4C	25834	broad.mit.edu	37	12	86373314	86373314	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr12:86373314delC	uc001tai.3	-	8	2440	c.1190delG	c.(1189-1191)GGAfs	p.G397fs	MGAT4C_uc001tal.3_Frame_Shift_Del_p.G397fs|MGAT4C_uc001taj.3_Frame_Shift_Del_p.G397fs|MGAT4C_uc001tak.3_Frame_Shift_Del_p.G397fs|MGAT4C_uc010sum.1_Frame_Shift_Del_p.G421fs|MGAT4C_uc001tah.3_Frame_Shift_Del_p.G397fs	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	397	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						ATCTTCTGTTCCAGTATTTAC	0.343			NA											16	43	---	---	---	---	NA	NA	NA	NA	NA
CD2BP2	10421	broad.mit.edu	37	16	30365550	30365552	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	CAT	CAT	-	-	CAT	CAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr16:30365550_30365552delCAT	uc002dxr.2	-	2	423_425	c.170_172delATG	c.(169-174)GATGGG>GGG	p.D57del	CD2BP2_uc002dxs.2_In_Frame_Del_p.D57del	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	57					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						CTGGACCCCCCATCATCATCATC	0.532			NA											7	360	---	---	---	---	NA	NA	NA	NA	NA
PIK3R5	23533	broad.mit.edu	37	17	8794155	8794155	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr17:8794155delC	uc002glt.2	-	7	624	c.557delG	c.(556-558)GGAfs	p.G186fs	PIK3R5_uc010vuz.1_Frame_Shift_Del_p.G186fs|PIK3R5_uc002glu.3_Intron|PIK3R5_uc010coa.1_Frame_Shift_Del_p.G186fs|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	186					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AGGCGAGTGTCCGGGCGTACT	0.642	NSCLC(18;589 615 7696 20311 50332)		NA											8	28	---	---	---	---	NA	NA	NA	NA	NA
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	AGC	-	rs141441894	byFrequency	TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	AGC	AGC	-	-	AGC	AGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr19:43969653_43969655delAGC	uc002owl.1	-	1	177_179	c.69_71delGCT	c.(67-72)CTGCTT>CTT	p.23_24LL>L	LYPD3_uc002owm.2_In_Frame_Del_p.23_24LL>L	NM_014400	NP_055215	O95274	LYPD3_HUMAN	GPI-anchored metastasis-associated protein	23_24						anchored to plasma membrane				pancreas(1)	1		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675			NA											9	189	---	---	---	---	NA	NA	NA	NA	NA
CTNNA2	1496	broad.mit.edu	37	2	80101445	80101446	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr2:80101445_80101446insC	uc010ysh.1	+	5	834_835	c.829_830insC	c.(829-831)GCTfs	p.A277fs	CTNNA2_uc010yse.1_Frame_Shift_Ins_p.A277fs|CTNNA2_uc010ysf.1_Frame_Shift_Ins_p.A277fs|CTNNA2_uc010ysg.1_Frame_Shift_Ins_p.A277fs	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	277					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CGGCGAGCTGGCTGCGGCTCTT	0.545			NA											31	69	---	---	---	---	NA	NA	NA	NA	NA
SLC17A9	63910	broad.mit.edu	37	20	61597059	61597059	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr20:61597059delT	uc002yea.3	+	10	1227	c.1043delT	c.(1042-1044)CTCfs	p.L348fs	SLC17A9_uc002ydz.3_Frame_Shift_Del_p.L342fs|SLC17A9_uc011aap.1_Frame_Shift_Del_p.L368fs	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	348					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TCCATCGGCCTCCAGACCTTC	0.642			NA											48	127	---	---	---	---	NA	NA	NA	NA	NA
BHLHE40	8553	broad.mit.edu	37	3	5024990	5024991	+	Frame_Shift_Ins	INS	-	-	C			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr3:5024990_5024991insC	uc003bqf.2	+	5	1159_1160	c.852_853insC	c.(850-855)GAACCCfs	p.E284fs	BHLHE40_uc011asw.1_Frame_Shift_Ins_p.E144fs	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	284_285						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGTCCGAAGAACCCCCCACAAA	0.559			NA											16	40	---	---	---	---	NA	NA	NA	NA	NA
AMPH	273	broad.mit.edu	37	7	38502605	38502605	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chr7:38502605delG	uc003tgu.2	-	10	927	c.858delC	c.(856-858)CCCfs	p.P286fs	AMPH_uc003tgv.2_Frame_Shift_Del_p.P286fs|AMPH_uc003tgt.2_Frame_Shift_Del_p.P39fs	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	286					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GTGCTGGTGCGGGAGACGCAG	0.547			NA											34	78	---	---	---	---	NA	NA	NA	NA	NA
L1CAM	3897	broad.mit.edu	37	X	153135618	153135620	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-44-6776-01A-11D-1855-08	TCGA-44-6776-10A-01D-1855-08	TTG	TTG	-	-	TTG	TTG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7d3c5101-fae2-4320-a8a2-a93753375368	3588228a-2ade-4230-a5c6-6599dbbbae3e	g.chrX:153135618_153135620delTTG	uc004fjb.2	-	8	990_992	c.882_884delCAA	c.(880-885)AACAAG>AAG	p.N294del	L1CAM_uc004fjc.2_In_Frame_Del_p.N294del|L1CAM_uc010nuo.2_In_Frame_Del_p.N289del|L1CAM_uc004fjd.1_In_Frame_Del_p.N108del|L1CAM_uc004fje.1_In_Frame_Del_p.N289del	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	294	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGCAGGGTCTTGTTGTGGTTCT	0.631			NA											106	277	---	---	---	---	NA	NA	NA	NA	NA
