Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC35E2B	728661	broad.mit.edu	37	1	1599899	1599899	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:1599899T>C	uc001ahf.3	-	9	1768	c.847A>G	c.(847-849)ATC>GTC	p.I283V	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc009vkl.1_Missense_Mutation_p.D200G|SLC35E2B_uc001ahe.3_Missense_Mutation_p.D65G|SLC35E2B_uc001ahg.3_Missense_Mutation_p.I283V|SLC35E2B_uc001ahh.3_Missense_Mutation_p.I283V	NM_001110781	NP_001104251	P0CK96	S352B_HUMAN	similar to solute carrier family 35, member E2	283	Helical; (Potential).					integral to membrane					0						CTCCTCCCGATCACTGGGACG	0.542			NA											14	69					0	0	0.008871	0	0
PRDM2	7799	broad.mit.edu	37	1	14142945	14142945	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:14142945G>A	uc001avi.2	+	9	5916	c.5060G>A	c.(5059-5061)CGA>CAA	p.R1687Q	PRDM2_uc001avg.2_Missense_Mutation_p.D179N|PRDM2_uc009voe.2_RNA|PRDM2_uc009vof.2_RNA	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1687						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TTGGCGTCCCGATGCTCTCCA	0.587			NA											19	38					0	0	0.001882	0	0
MST1P2	11209	broad.mit.edu	37	1	16975289	16975289	+	Splice_Site	SNP	T	T	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:16975289T>A	uc010och.1	+	8		c.1656_splice	c.e8+2		MST1P2_uc001azl.3_Splice_Site|MST1P2_uc009vox.2_Splice_Site|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						CCCCCCCAGGTTAGGAGTTGG	0.577			NA											14	74					0	0	0.004007	0	0
UBR4	23352	broad.mit.edu	37	1	19448475	19448475	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:19448475G>A	uc001bbi.2	-	67	9852	c.9848C>T	c.(9847-9849)GCC>GTC	p.A3283V	UBR4_uc001bbk.1_Missense_Mutation_p.A930V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3283					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCGCTGGGCGGCAATCTCTGC	0.443			NA											3	30					0	0	0.004672	0	0
INADL	10207	broad.mit.edu	37	1	62349930	62349930	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:62349930A>G	uc001dab.2	+	22	3095	c.2981A>G	c.(2980-2982)CAA>CGA	p.Q994R	INADL_uc009waf.1_Missense_Mutation_p.Q994R|INADL_uc001daa.2_Missense_Mutation_p.Q994R|INADL_uc001dad.3_Missense_Mutation_p.Q691R|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	994					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AATGATGTCCAAGGTCCTAGC	0.398			NA											56	130					0	0	0.00361	0	0
DBT	1629	broad.mit.edu	37	1	100676288	100676288	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:100676288C>A	uc001dta.2	-	8	1012	c.979G>T	c.(979-981)GCT>TCT	p.A327S	DBT_uc010oug.1_Missense_Mutation_p.A146S	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	327					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding	p.A327T(1)		pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TCCACAGAAGCGTTAAGGATA	0.338			NA											20	75					1.50039e-11	1.94098e-11	0.001882	1	0
KIAA1324	57535	broad.mit.edu	37	1	109707159	109707159	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:109707159G>T	uc001dwq.2	+	4	449	c.313G>T	c.(313-315)GAC>TAC	p.D105Y	KIAA1324_uc009wex.1_Missense_Mutation_p.D105Y|KIAA1324_uc009wey.2_Missense_Mutation_p.D105Y|KIAA1324_uc010ovg.1_Missense_Mutation_p.D3Y	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	105	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane		p.D105E(1)		ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GGATATGAAGGACCAGTCATG	0.587			NA											36	114					6.97489e-18	9.55384e-18	0.004878	1	0
NBPF15	284565	broad.mit.edu	37	1	148594621	148594621	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:148594621G>A	uc001esc.2	+	19	2483	c.1994G>A	c.(1993-1995)GGA>GAA	p.G665E		NM_173638	NP_775909	Q8N660	NBPFF_HUMAN	hypothetical protein LOC284565	665	NBPF 6.					cytoplasm					0	all_hematologic(923;0.032)					TTCCAGATGGGAGTCATATTC	0.443			NA											5	191					0	0	0.001984	0	0
FAM5C	339479	broad.mit.edu	37	1	190068054	190068054	+	Silent	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:190068054G>T	uc001gse.1	-	8	1627	c.1395C>A	c.(1393-1395)ACC>ACA	p.T465T	FAM5C_uc010pot.1_Silent_p.T363T	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	465						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GCATGTAGCCGGTGTTGCAGG	0.597			NA											52	109					1.42923e-14	1.92532e-14	0.00361	1	0
SLC41A1	254428	broad.mit.edu	37	1	205760707	205760707	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:205760707T>A	uc001hdh.1	-	11	2368	c.1496A>T	c.(1495-1497)CAT>CTT	p.H499L	SLC41A1_uc001hdg.1_Missense_Mutation_p.H120L	NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	499	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			CCAGAGAACATGGAAGCTGAG	0.552			NA									OREG0014162	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	37					0	0	0.000248	0	0
KCNK2	3776	broad.mit.edu	37	1	215342563	215342563	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:215342563G>T	uc001hkq.2	+	4	666	c.497G>T	c.(496-498)CGC>CTC	p.R166L	KCNK2_uc001hko.2_Missense_Mutation_p.R162L|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.R151L	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	166							outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	ATCTCACCACGCACAGAAGGC	0.294			NA											33	92					8.73648e-17	1.18671e-16	0.004289	1	0
RAB3GAP2	25782	broad.mit.edu	37	1	220345342	220345342	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:220345342C>A	uc010puk.1	-	23	2630	c.2466G>T	c.(2464-2466)CAG>CAT	p.Q822H	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.Q402H	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	822					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		TGCGCATCTGCTGCCACCATG	0.468			NA											20	41					1.33834e-09	1.66526e-09	0.007413	1	0
GPR137B	7107	broad.mit.edu	37	1	236343183	236343183	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:236343183C>T	uc001hxq.2	+	4	783	c.692C>T	c.(691-693)TCC>TTC	p.S231F	GPR137B_uc001hxr.1_Missense_Mutation_p.S13F|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	231	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TTCCAGGGCTCCTCCGTGTGT	0.547			NA											59	151					0	0	0.00361	0	0
COL13A1	1305	broad.mit.edu	37	10	71716763	71716763	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr10:71716763G>A	uc001jpr.1	+	38	2652	c.2116G>A	c.(2116-2118)GAA>AAA	p.E706K	COL13A1_uc001jqj.1_Missense_Mutation_p.E679K|COL13A1_uc001jps.1_Missense_Mutation_p.E677K|COL13A1_uc001jpt.1_Missense_Mutation_p.E665K|COL13A1_uc001jpu.1_Missense_Mutation_p.E675K|COL13A1_uc001jpv.1_Missense_Mutation_p.E680K|COL13A1_uc001jpx.1_Missense_Mutation_p.E657K|COL13A1_uc001jpw.1_Missense_Mutation_p.E653K|COL13A1_uc001jpy.1_Missense_Mutation_p.E644K|COL13A1_uc001jpz.1_Missense_Mutation_p.E649K|COL13A1_uc001jqa.1_Missense_Mutation_p.E646K|COL13A1_uc001jqc.1_Missense_Mutation_p.E691K|COL13A1_uc001jqb.1_Missense_Mutation_p.E599K|COL13A1_uc001jql.2_Missense_Mutation_p.E706K|COL13A1_uc001jqd.1_Missense_Mutation_p.E694K|COL13A1_uc001jqe.1_Missense_Mutation_p.E689K|COL13A1_uc001jqf.1_Missense_Mutation_p.E687K|COL13A1_uc001jqg.1_Missense_Mutation_p.E684K|COL13A1_uc001jqh.1_Missense_Mutation_p.E694K|COL13A1_uc001jqi.1_Missense_Mutation_p.E692K|COL13A1_uc010qjf.1_Missense_Mutation_p.E481K	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	706	Extracellular (Potential).|Nonhelical region 4 (NC4).			E -> Q (in Ref. 4; AAA52047/AAA52048 and 5; AAA51987/AAA51988/AAA51989/AAA51990/ AAA51991).	cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	CTTGCAGGGCGAAGATGGCTT	0.557			NA											14	36					0	0	0.00499	0	0
TH	7054	broad.mit.edu	37	11	2189322	2189322	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:2189322G>T	uc001lvq.2	-	5	687	c.668C>A	c.(667-669)CCG>CAG	p.P223Q	TH_uc001lvp.2_Missense_Mutation_p.P219Q|TH_uc001lvr.2_Missense_Mutation_p.P192Q|TH_uc010qxj.1_Missense_Mutation_p.P196Q|TH_uc001lvs.2_Missense_Mutation_p.P192Q|TH_uc001lvt.2_Missense_Mutation_p.P196Q|TH_uc009ydh.1_RNA	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	223					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	ACCACTCACCGGGTGGTCCAA	0.597			NA											10	52					0.000442599	0.000494135	0.006214	1	0
OR2AG2	338755	broad.mit.edu	37	11	6789746	6789746	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:6789746G>C	uc001meq.1	-	1	443	c.443C>G	c.(442-444)TCC>TGC	p.S148C		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAGGATCCAGGATGTGGCCAC	0.507			NA											12	56					0	0	0.001368	0	0
EXT2	2132	broad.mit.edu	37	11	44135768	44135768	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:44135768G>T	uc001mxz.2	+	4	994	c.660G>T	c.(658-660)TGG>TGT	p.W220C	EXT2_uc010rfo.1_Missense_Mutation_p.W248C|EXT2_uc001mxy.2_Missense_Mutation_p.W233C|EXT2_uc009ykt.2_Missense_Mutation_p.W220C|EXT2_uc001mya.2_Missense_Mutation_p.W253C	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	220	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						TTTCTACGTGGACTTACCGGC	0.473			NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				43	116					3.43241e-23	4.74139e-23	0.002222	1	0
PGR	5241	broad.mit.edu	37	11	100962496	100962496	+	Missense_Mutation	SNP	A	A	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:100962496A>C	uc001pgh.2	-	3	2644	c.1901T>G	c.(1900-1902)CTT>CGT	p.L634R	PGR_uc001pgi.2_Missense_Mutation_p.L634R|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_Intron	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	634	Nuclear receptor.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	ATTACCTCCAAGGACCATGCC	0.363	Pancreas(124;2271 2354 21954 22882)		NA											11	25					0	0	0.001855	0	0
AMICA1	120425	broad.mit.edu	37	11	118081271	118081271	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:118081271G>A	uc001psk.2	-	4	529	c.355C>T	c.(355-357)CGC>TGC	p.R119C	AMICA1_uc001psh.2_Missense_Mutation_p.R80C|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.R109C|AMICA1_uc001psj.2_Missense_Mutation_p.R119C|AMICA1_uc010rxw.1_Missense_Mutation_p.R80C|AMICA1_uc010rxx.1_Missense_Mutation_p.R119C|AMICA1_uc001psl.1_Missense_Mutation_p.R75C	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	119	Ig-like V-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCTTTGAGGCGGATTTCACAG	0.522			NA											28	88					0	0	0.008361	0	0
ROBO4	54538	broad.mit.edu	37	11	124756661	124756661	+	Silent	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:124756661G>A	uc001qbg.2	-	16	2633	c.2493C>T	c.(2491-2493)ATC>ATT	p.I831I	ROBO4_uc010sas.1_Silent_p.I686I|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Silent_p.I389I	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	831					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TTGGGACGCTGATGTACCCAT	0.622			NA											26	43					0	0	0.005443	0	0
KCNA6	3742	broad.mit.edu	37	12	4920464	4920464	+	Silent	SNP	A	A	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr12:4920464A>T	uc001qng.2	+	1	2123	c.1257A>T	c.(1255-1257)ACA>ACT	p.T419T		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	419						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CAGTGGTTACAATGACCACGG	0.587			NA								HNSCC(72;0.22)			21	79					0	0	0.001882	0	0
DIP2B	57609	broad.mit.edu	37	12	51065071	51065071	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr12:51065071G>A	uc001rwv.2	+	5	686	c.530G>A	c.(529-531)CGT>CAT	p.R177H	DIP2B_uc001rwu.2_Missense_Mutation_p.R177H|DIP2B_uc009zls.1_Missense_Mutation_p.R59H	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	177	Ser-rich.					nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TGGATCAACCGTTCAATTCAG	0.527			NA											17	112					0	0	0.004007	0	0
OR10P1	121130	broad.mit.edu	37	12	56031203	56031203	+	Silent	SNP	G	G	T	rs147317388	byFrequency	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr12:56031203G>T	uc010spq.1	+	1	528	c.528G>T	c.(526-528)CCG>CCT	p.P176P		NM_206899	NP_996782	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						CGATCATCCCGCACTTTCTCT	0.562			NA											20	100					1.01871e-10	1.29727e-10	0.008871	1	0
TPCN1	53373	broad.mit.edu	37	12	113710467	113710467	+	Silent	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr12:113710467C>T	uc001tuw.2	+	8	1050	c.753C>T	c.(751-753)TTC>TTT	p.F251F	TPCN1_uc001tux.2_Silent_p.F323F|TPCN1_uc010syt.1_Silent_p.F183F	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	251	Helical; Name=S5 of repeat I; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TTCTAGGTTTCTACTTGTTCT	0.468			NA											131	251					0	0	0.00361	0	0
TPCN1	53373	broad.mit.edu	37	12	113717996	113717996	+	Silent	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr12:113717996C>T	uc001tuw.2	+	15	1635	c.1338C>T	c.(1336-1338)TTC>TTT	p.F446F	TPCN1_uc001tux.2_Silent_p.F518F|TPCN1_uc010syt.1_Silent_p.F378F	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	446	Helical; Name=S1 of repeat II; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TCCAGTATTTCATGTGTAAGT	0.423			NA											13	49					0	0	0.001855	0	0
LOC647288	647288	broad.mit.edu	37	13	75814192	75814192	+	Silent	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr13:75814192T>C	uc010ths.1	-	1	326	c.285A>G	c.(283-285)AAA>AAG	p.K95K		NR_027466				Homo sapiens mRNA; cDNA DKFZp434F0327 (from clone DKFZp434F0327).												0						TAAGGCTAAATTTTTCAAGTA	0.393			NA											12	200					0	0	0.000978	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328860	88328860	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr13:88328860C>T	uc001vln.2	+	2	1436	c.1217C>T	c.(1216-1218)CCC>CTC	p.P406L	SLITRK5_uc010tic.1_Missense_Mutation_p.P165L	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	406	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GAACTGCAGCCCAAGCCCTAC	0.567			NA											14	32					0	0	0.001855	0	0
ABHD12B	145447	broad.mit.edu	37	14	51352570	51352570	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr14:51352570G>C	uc001wys.2	+	7	634	c.619G>C	c.(619-621)GGC>CGC	p.G207R	ABHD12B_uc001wyq.2_Missense_Mutation_p.G100R|ABHD12B_uc001wyr.2_Missense_Mutation_p.G130R|ABHD12B_uc010any.2_Intron	NM_181533	NP_853511	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B isoform b	207							hydrolase activity			breast(1)	1	all_epithelial(31;0.00481)|Breast(41;0.148)					GGCAAGAAGTGGCATCACTCC	0.522			NA											47	124					0	0	0.003214	0	0
NID2	22795	broad.mit.edu	37	14	52507564	52507564	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr14:52507564C>A	uc001wzo.2	-	8	2065	c.1831G>T	c.(1831-1833)GCC>TCC	p.A611S	NID2_uc010tqs.1_Missense_Mutation_p.A611S|NID2_uc010tqt.1_Missense_Mutation_p.A611S|NID2_uc001wzp.2_Missense_Mutation_p.A611S	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	611	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TGGGTAAAGGCAGCACCTGGA	0.473			NA											23	89					3.62473e-10	4.54486e-10	0.001882	1	0
KCNK10	54207	broad.mit.edu	37	14	88693778	88693778	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr14:88693778C>G	uc001xwo.2	-	4	1064	c.607G>C	c.(607-609)GGA>CGA	p.G203R	KCNK10_uc001xwm.2_Missense_Mutation_p.G208R|KCNK10_uc001xwn.2_Missense_Mutation_p.G208R	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	203	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						AGTTGGTCTCCAATTCCAGCC	0.403			NA											49	136					0	0	0.00361	0	0
JAG2	3714	broad.mit.edu	37	14	105609331	105609331	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr14:105609331G>A	uc001yqg.2	-	26	3822	c.3418C>T	c.(3418-3420)CGG>TGG	p.R1140W	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Missense_Mutation_p.R544W|JAG2_uc001yqh.2_Missense_Mutation_p.R1102W	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1140	Cytoplasmic (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCCCCCGGCCGCTCAATGGGG	0.483			NA											15	24					0	0	0.004007	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32915726	32915726	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr15:32915726C>G	uc001zgy.1	+	3	956	c.234C>G	c.(232-234)GAC>GAG	p.D78E	ARHGAP11A_uc010ubw.1_5'UTR|ARHGAP11A_uc001zgw.2_Missense_Mutation_p.D78E|ARHGAP11A_uc001zgx.2_Missense_Mutation_p.D78E|ARHGAP11A_uc010ubx.1_5'UTR	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	78	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		CTTTAGAAGACCATATTCATA	0.373	Colon(45;757 1134 30003 36652)		NA											17	93					0	0	0.001523	0	0
RASGRP1	10125	broad.mit.edu	37	15	38791143	38791143	+	Silent	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr15:38791143G>A	uc001zke.3	-	15	1903	c.1725C>T	c.(1723-1725)TGC>TGT	p.C575C	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Silent_p.C402C|RASGRP1_uc010bbg.2_Intron|RASGRP1_uc001zkd.3_Silent_p.C540C	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	575	Phorbol-ester/DAG-type.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		AGTTCATCCCGCAGTCTGTGG	0.468			NA											5	331					0	0	0.001168	0	0
STRC	161497	broad.mit.edu	37	15	43892287	43892287	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr15:43892287G>A	uc001zsf.2	-	28	5188	c.5110C>T	c.(5110-5112)CAA>TAA	p.Q1704*	STRC_uc010bdl.2_Nonsense_Mutation_p.Q931*|STRC_uc001zse.2_Nonsense_Mutation_p.Q222*	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1704					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CTAGATAGTTGGATGGGACTA	0.557			NA											17	35					0	0	0.007413	0	0
UNC13C	440279	broad.mit.edu	37	15	54793103	54793103	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr15:54793103G>A	uc002ack.2	+	20	5228	c.5228G>A	c.(5227-5229)AGC>AAC	p.S1743N		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1743	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTGAATCAGAGCTTTGAAATT	0.408			NA											13	100					0	0	0.00245	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72954797	72954797	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr15:72954797T>C	uc010uks.1	+	11	1093	c.1052T>C	c.(1051-1053)GTG>GCG	p.V351A		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	351	Potential.										0						GAGCAGGAGGTGCAGAGAGTG	0.562			NA											3	0					0	0	0.000602	0	0
USP7	7874	broad.mit.edu	37	16	8993490	8993490	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr16:8993490T>A	uc002czl.2	-	22	2633	c.2434A>T	c.(2434-2436)ACG>TCG	p.T812S	USP7_uc010uyk.1_Missense_Mutation_p.T713S|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.T713S|USP7_uc002czk.2_Missense_Mutation_p.T796S	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	812					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						TTTGATAACGTAACCACAAAT	0.363			NA											37	79					0	0	0.005524	0	0
RSL1D1	26156	broad.mit.edu	37	16	11931885	11931885	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr16:11931885G>A	uc002dbp.1	-	9	1305	c.1232C>T	c.(1231-1233)CCA>CTA	p.P411L	RSL1D1_uc010buv.1_Missense_Mutation_p.P410L|RSL1D1_uc010uyw.1_Missense_Mutation_p.P191L	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	411					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						ctcagatgctggcaaagcctt	0.159			NA											18	501					0	0	0.006122	0	0
CCDC113	29070	broad.mit.edu	37	16	58312467	58312467	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr16:58312467G>A	uc002ene.2	+	8	1052	c.973G>A	c.(973-975)GTC>ATC	p.V325I	CCDC113_uc010vid.1_Missense_Mutation_p.V271I	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	325	Potential.					protein complex					0						GATGACTTACGTCCGGGAGAA	0.587			NA											34	50					0	0	0.002836	0	0
NUP88	4927	broad.mit.edu	37	17	5317415	5317415	+	Silent	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr17:5317415G>A	uc002gbo.1	-	3	533	c.507C>T	c.(505-507)ACC>ACT	p.T169T	NUP88_uc010vsx.1_Silent_p.T169T|NUP88_uc010cle.1_Silent_p.T169T|NUP88_uc010vsy.1_Silent_p.T169T	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	169					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						GAGTCAGAGAGGTGGAACTGG	0.368			NA											14	12					0	0	0.001855	0	0
TP53	7157	broad.mit.edu	37	17	7578536	7578536	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr17:7578536T>C	uc002gim.2	-	5	588	c.394A>G	c.(394-396)AAG>GAG	p.K132E	TP53_uc002gig.1_Missense_Mutation_p.K132E|TP53_uc002gih.2_Missense_Mutation_p.K132E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132E|TP53_uc010cni.1_Missense_Mutation_p.K132E|TP53_uc002gij.2_Missense_Mutation_p.K132E|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K39E|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(40)|p.K132R(32)|p.K132E(19)|p.K132Q(13)|p.K132M(9)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.K132T(4)|p.K132*(2)|p.N131del(2)|p.N131fs*27(2)|p.K132fs*38(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.V73fs*9(1)|p.L130fs*16(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.K132_A138delKMFCQLA(1)|p.S127fs*36(1)|p.K132K(1)|p.K132W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAAACATCTTGTTGAGGGCA	0.557	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	15					0	0	0.004482	0	0
CCL8	6355	broad.mit.edu	37	17	32646553	32646553	+	Silent	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr17:32646553G>T	uc002hib.2	+	1	488	c.33G>T	c.(31-33)CTG>CTT	p.L11L		NM_005623	NP_005614	P80075	CCL8_HUMAN	small inducible cytokine A8 precursor	11					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				TGTGCCTGCTGCTCATGGCAG	0.512			NA											13	51					3.45872e-05	3.94245e-05	0.004007	1	0
Unknown	0	broad.mit.edu	37	17	45127332	45127332	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr17:45127332G>A	uc010wkj.1	+	2	884	c.530G>A	c.(529-531)CGC>CAC	p.R177H	uc010wkl.1_RNA					SubName: Full=Putative uncharacterized protein LRRC37A3;												NA						ACTCGCTCCCGCATGACCCAC	0.418			NA											5	216					0	0	0.001168	0	0
KCTD2	23510	broad.mit.edu	37	17	73045381	73045381	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr17:73045381C>T	uc002jmp.2	+	2	473	c.406C>T	c.(406-408)CGC>TGC	p.R136C	KCTD2_uc010dfy.1_RNA|KCTD2_uc010dfz.2_RNA|ATP5H_uc002jmn.1_5'Flank|ATP5H_uc002jmo.1_5'Flank|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	136	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					CAACTACCTCCGCCACGGGAA	0.468			NA											8	84					0	0	0.00308	0	0
NPLOC4	55666	broad.mit.edu	37	17	79580446	79580446	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr17:79580446G>A	uc002kat.3	-	4	466	c.284C>T	c.(283-285)CCG>CTG	p.P95L	NPLOC4_uc002kau.3_Missense_Mutation_p.P95L|NPLOC4_uc010wur.1_5'UTR	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	95					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TTTGAAGCCCGGTGGAACTGA	0.517			NA											33	29					0	0	0.003271	0	0
POTEC	388468	broad.mit.edu	37	18	14542693	14542693	+	Silent	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr18:14542693C>T	uc010dln.2	-	1	907	c.453G>A	c.(451-453)AAG>AAA	p.K151K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	151	ANK 1.									skin(3)	3						TTCTGGGGACCTTACCCCACC	0.592			NA											6	171					0	0	0.008291	0	0
ZNF521	25925	broad.mit.edu	37	18	22804461	22804462	+	Missense_Mutation	DNP	AG	AG	TA			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr18:22804461_22804462AG>TA	uc002kvk.2	-	4	3667_3668	c.3420_3421CT>TA	c.(3418-3423)TGCTCT>TGTACT	p.S1141T	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S1141T|ZNF521_uc002kvl.2_Missense_Mutation_p.S921T	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1141	C2H2-type 26.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTGCAGCTAGAGCAGCGTGTCT	0.53			NA	T	PAX5	ALL								25	45					0	0	0.004672	0	0
TCF4	6925	broad.mit.edu	37	18	52901847	52901847	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr18:52901847G>T	uc002lfz.2	-	16	2030	c.1418C>A	c.(1417-1419)CCG>CAG	p.P473Q	TCF4_uc002lfw.3_Missense_Mutation_p.P313Q|TCF4_uc010xdu.1_Missense_Mutation_p.P343Q|TCF4_uc010xdv.1_Missense_Mutation_p.P343Q|TCF4_uc002lfx.2_Missense_Mutation_p.P402Q|TCF4_uc010xdw.1_Missense_Mutation_p.P343Q|TCF4_uc002lfy.2_Missense_Mutation_p.P431Q|TCF4_uc010xdx.1_Missense_Mutation_p.P449Q|TCF4_uc010dph.1_Missense_Mutation_p.P473Q|TCF4_uc010xdy.1_Missense_Mutation_p.P449Q|TCF4_uc002lga.2_Missense_Mutation_p.P575Q|TCF4_uc002lgb.1_Missense_Mutation_p.P313Q|TCF4_uc010dpi.2_Missense_Mutation_p.P479Q|TCF4_uc002lfv.2_Missense_Mutation_p.P256Q	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	473					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CTGTGGAACCGGAACCTGGTT	0.597			NA									OREG0024990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	60					1.01871e-10	1.29727e-10	0.008871	1	0
STK11	6794	broad.mit.edu	37	19	1220685	1220685	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:1220685A>T	uc002lrl.1	+	5	1818	c.703A>T	c.(703-705)AAG>TAG	p.K235*		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	235	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(2)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCGGCTTCAAGGTGGACAT	0.697			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			12	17					0	0	0.000978	0	0
KEAP1	9817	broad.mit.edu	37	19	10610285	10610285	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:10610285G>A	uc002moq.1	-	2	581	c.425C>T	c.(424-426)ACG>ATG	p.T142M	KEAP1_uc002mor.1_Missense_Mutation_p.T142M	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	142	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GATGGAGGCCGTGTAGGCGAA	0.587			NA											17	22					0	0	0.00499	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567			NA											3	47					0	0	0.004672	0	0
ZNF254	9534	broad.mit.edu	37	19	24310436	24310436	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:24310436C>G	uc002nru.2	+	4	1768	c.1634C>G	c.(1633-1635)CCC>CGC	p.P545R	ZNF254_uc010xrk.1_Missense_Mutation_p.P460R	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	545					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				GAAGAGAAACCCTACAAATGT	0.363			NA											13	26					0	0	0.001368	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769002	31769002	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:31769002G>T	uc002nsy.3	-	2	1762	c.1697C>A	c.(1696-1698)TCG>TAG	p.S566*		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	566					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.M566I(1)		ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CTTCCCCGACGAGCCCAGGGA	0.587			NA											38	56					1.67305e-13	2.21713e-13	0.00623	1	0
LSM14A	26065	broad.mit.edu	37	19	34712504	34712504	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:34712504G>A	uc002nvb.3	+	9	1425	c.1229G>A	c.(1228-1230)AGA>AAA	p.R410K	LSM14A_uc002nva.3_Missense_Mutation_p.R410K|LSM14A_uc010xru.1_Missense_Mutation_p.R369K|LSM14A_uc002nvc.3_Missense_Mutation_p.R216K	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	LSM14 homolog A isoform a	410					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)					GGGGGATACAGAGGCAGAGGA	0.537			NA											12	32					0	0	0.001855	0	0
CD37	951	broad.mit.edu	37	19	49843570	49843570	+	Silent	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:49843570C>A	uc002pnd.2	+	8	952	c.831C>A	c.(829-831)CTC>CTA	p.L277L	uc002pnb.1_5'Flank|CD37_uc002pnc.2_RNA|CD37_uc002pne.2_Silent_p.L209L	NM_001774	NP_001765	P11049	CD37_HUMAN	CD37 antigen isoform A	277	Cytoplasmic (Potential).					integral to membrane					0		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		ACAACCGGCTCGCTCGATACC	0.577			NA											20	24					1.22574e-08	1.5136e-08	0.002299	1	0
KLK7	5650	broad.mit.edu	37	19	51483661	51483661	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:51483661G>C	uc002puo.2	-	4	406	c.304C>G	c.(304-306)CCC>GCC	p.P102A	KLK7_uc002pup.2_Missense_Mutation_p.P102A|KLK7_uc010yco.1_5'UTR|KLK7_uc010eok.2_Missense_Mutation_p.P30A	NM_139277	NP_644806	P49862	KLK7_HUMAN	stratum corneum chymotryptic enzyme	102	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		GAGTAGCCGGGGTGGCGGAAT	0.572			NA											17	22					0	0	0.00499	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55340832	55340832	+	Silent	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr19:55340832G>A	uc002qhk.3	+	7	1080	c.1017G>A	c.(1015-1017)CTG>CTA	p.L339L	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Silent_p.L264L|KIR3DL1_uc010esf.2_Silent_p.L244L|KIR3DL1_uc010yfo.1_Silent_p.L281L|KIR3DL1_uc002qhl.3_Intron	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	339	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CCAGACACCTGCACATTCTGA	0.338			NA											2	0					0	0	0.004672	0	0
LTBP1	4052	broad.mit.edu	37	2	33359878	33359878	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:33359878G>A	uc002ros.2	+	5	1052	c.1052G>A	c.(1051-1053)CGC>CAC	p.R351H	LTBP1_uc002rot.2_Missense_Mutation_p.R25H|LTBP1_uc002rou.2_Missense_Mutation_p.R25H|LTBP1_uc002rov.2_Missense_Mutation_p.R25H|LTBP1_uc010ymz.1_Missense_Mutation_p.R25H|LTBP1_uc010yna.1_Missense_Mutation_p.R25H	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	351					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CACACTGGCCGCATCAAGGTG	0.478			NA											4	141					0	0	0.000602	0	0
EPCAM	4072	broad.mit.edu	37	2	47606164	47606164	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:47606164G>A	uc002rvx.2	+	6	986	c.628G>A	c.(628-630)GCT>ACT	p.A210T	EPCAM_uc002rvw.2_Missense_Mutation_p.A238T	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	210	Extracellular (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						TGTGGACATAGCTGATGTGGC	0.294			NA							Lynch_syndrome				20	68					0	0	0.001882	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48848037	48848037	+	Silent	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:48848037G>T	uc010yol.1	+	3	2228	c.2181G>T	c.(2179-2181)CGG>CGT	p.R727R	STON1-GTF2A1L_uc002rwp.1_Silent_p.R727R|GTF2A1L_uc002rws.1_Silent_p.R23R|GTF2A1L_uc010yom.1_Intron|GTF2A1L_uc002rwt.2_Silent_p.R23R	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	727					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAGGAGTTCGGAATCTATTTG	0.289			NA											13	44					0.00316338	0.00350769	0.003163	1	0
RPL23AP32	56969	broad.mit.edu	37	2	54756736	54756736	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:54756736T>C	uc010yot.1	+	1	378	c.254T>C	c.(253-255)TTT>TCT	p.F85S	SPTBN1_uc002rxu.2_Intron|SPTBN1_uc002rxv.1_Intron	NR_002229				SubName: Full=Putative uncharacterized protein DKFZp547I014;												0						ACCACTGAGTTTGCCATGAAG	0.483			NA											3	63					0	0	0.000248	0	0
RGPD4	285190	broad.mit.edu	37	2	108488692	108488692	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:108488692T>C	uc010ywk.1	+	20	4314	c.4232T>C	c.(4231-4233)ATA>ACA	p.I1411T	RGPD4_uc002tdu.2_Missense_Mutation_p.I598T|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1411	RanBD1 2.				intracellular transport		binding			skin(2)	2						AATCACACAATAACTCCAGAC	0.358			NA											239	511					0	0	0.00361	0	0
LRP1B	53353	broad.mit.edu	37	2	141709451	141709451	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:141709451G>T	uc002tvj.1	-	19	3918	c.2946C>A	c.(2944-2946)AGC>AGA	p.S982R	LRP1B_uc010fnl.1_Missense_Mutation_p.S164R	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	982	Extracellular (Potential).|LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCATTTGCTGCTAATGCATC	0.443	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			20	31					7.92952e-12	1.03401e-11	0.003954	1	0
ARL5A	26225	broad.mit.edu	37	2	152663470	152663470	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:152663470C>G	uc002txx.1	-	5	675	c.356G>C	c.(355-357)GGA>GCA	p.G119A	ARL5A_uc010zcc.1_RNA|ARL5A_uc002txv.1_Missense_Mutation_p.G82A|ARL5A_uc002txw.1_Missense_Mutation_p.G82A	NM_012097	NP_036229	Q9Y689	ARL5A_HUMAN	ADP-ribosylation factor-like 5A isoform 1	119					small GTPase mediated signal transduction	intracellular	GTP binding				0				BRCA - Breast invasive adenocarcinoma(221;0.153)		AATCAGCAATCCAGCTTTTCT	0.318			NA											6	53					0	0	0.004482	0	0
GCA	25801	broad.mit.edu	37	2	163208879	163208879	+	Missense_Mutation	SNP	G	G	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:163208879G>C	uc002ucg.2	+	3	400	c.224G>C	c.(223-225)AGA>ACA	p.R75T	GCA_uc010zcu.1_Missense_Mutation_p.R56T	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	75	EF-hand 1.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0						GAACTTCAGAGATGTTTGACA	0.299			NA											20	69					0	0	0.001882	0	0
FIGN	55137	broad.mit.edu	37	2	164466086	164466086	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:164466086G>T	uc002uck.1	-	3	2567	c.2256C>A	c.(2254-2256)AAC>AAA	p.N752K		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	752						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CAAACATTTTGTTCCATTCAA	0.378			NA											8	62					0.000157383	0.000176921	0.00308	1	0
SCN1A	6323	broad.mit.edu	37	2	166900385	166900385	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:166900385G>A	uc010zcz.1	-	11	1855	c.1837C>T	c.(1837-1839)CGA>TGA	p.R613*	SCN1A_uc002udo.3_Nonsense_Mutation_p.R482*|SCN1A_uc010fpk.2_Nonsense_Mutation_p.R482*	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	613						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTCCGTGTCGTCGGGGCACA	0.542			NA											12	57					0	0	0.000978	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726189	168726189	+	Silent	SNP	C	C	A	rs144099662	byFrequency	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:168726189C>A	uc002udz.1	+	2	991	c.640C>A	c.(640-642)CGG>AGG	p.R214R		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	214	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						AGGACCGATTCGGGATGTCCG	0.438			NA											9	75					7.48243e-07	8.90245e-07	0.006214	1	0
PLEKHA3	65977	broad.mit.edu	37	2	179358664	179358664	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:179358664C>T	uc002umn.2	+	4	796	c.398C>T	c.(397-399)ACA>ATA	p.T133I		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	133						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			CAAGTTCATACAATACAGGAA	0.403			NA											8	68					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179432140	179432140	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:179432140C>A	uc010zfg.1	-	275	71239	c.71015G>T	c.(71014-71016)TGT>TTT	p.C23672F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.C17367F|TTN_uc010zfi.1_Missense_Mutation_p.C17300F|TTN_uc010zfj.1_Missense_Mutation_p.C17175F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24599							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTATTTCACATCTAGCAGA	0.388			NA											61	159					4.32865e-36	6.03051e-36	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179614601	179614601	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:179614601T>A	uc002unb.2	-	46	12750	c.12526A>T	c.(12526-12528)ATC>TTC	p.I4176F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAAGAATGATGGAATCCCCT	0.373			NA											22	45					0	0	0.001882	0	0
AOX1	316	broad.mit.edu	37	2	201468820	201468820	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:201468820G>T	uc002uvx.2	+	8	770	c.669G>T	c.(667-669)ATG>ATT	p.M223I		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	223					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CTGAGCTAATGGTGAGTAAAG	0.403			NA											19	33					2.94398e-08	3.58111e-08	0.007413	1	0
RBM44	375316	broad.mit.edu	37	2	238729761	238729761	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:238729761T>C	uc002vxi.3	+	6	2096	c.1964T>C	c.(1963-1965)CTG>CCG	p.L655P		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	654							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		TCAGCACTACTGTCTCTTTTG	0.378			NA											16	30					0	0	0.00499	0	0
AGXT	189	broad.mit.edu	37	2	241812439	241812439	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:241812439G>A	uc002waa.3	+	5	689	c.568G>A	c.(568-570)GGG>AGG	p.G190R	AGXT_uc010zoi.1_Missense_Mutation_p.G190R	NM_000030	NP_000021	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	190			G -> R (in HP1).		glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity				0		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ATCCCTGGGCGGGACCCCCCT	0.662			NA											13	84					0	0	0.003163	0	0
FRG1B	284802	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr20:29625875T>C	uc010ztl.1	+	2	61	c.29T>C	c.(28-30)ATC>ACC	p.I10T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ATGTACAGAATCGCCCTGAAA	0.353			NA											3	79					0	0	0.00308	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr20:29625877G>A	uc010ztl.1	+	2	63	c.31G>A	c.(31-33)GCC>ACC	p.A11T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTACAGAATCGCCCTGAAATC	0.353			NA											5	79					0	0	0.00308	0	0
FRG1B	284802	broad.mit.edu	37	20	29625895	29625895	+	Missense_Mutation	SNP	G	G	A	rs76435412	by1000genomes	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr20:29625895G>A	uc010ztl.1	+	2	81	c.49G>A	c.(49-51)GGA>AGA	p.G17R	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ATCTGGCTATGGAAAATATCT	0.343			NA											15	74					0	0	0.007413	0	0
FRG1B	284802	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr20:29625941A>T	uc010ztl.1	+	2	127	c.95A>T	c.(94-96)GAT>GTT	p.D32V	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GGGCATTCAGATGCAATTGGA	0.333			NA											6	70					0	0	0.008291	0	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr20:29628263A>G	uc010ztl.1	+	3	207	c.175A>G	c.(175-177)ATT>GTT	p.I59V	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.I11V					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TAGCTGCTTTATTAGATGCAA	0.363			NA											3	66					0	0	0.001984	0	0
PARD6B	84612	broad.mit.edu	37	20	49366455	49366455	+	Silent	SNP	A	A	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr20:49366455A>G	uc002xvo.2	+	3	792	c.549A>G	c.(547-549)CCA>CCG	p.P183P		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	183	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						GGGTAACACCACATGGCTTAG	0.473			NA											22	41					0	0	0.001882	0	0
DIDO1	11083	broad.mit.edu	37	20	61541330	61541330	+	Silent	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr20:61541330G>A	uc002ydr.1	-	4	1146	c.882C>T	c.(880-882)GGC>GGT	p.G294G	DIDO1_uc002yds.1_Silent_p.G294G|DIDO1_uc002ydt.1_Silent_p.G294G|DIDO1_uc002ydu.1_Silent_p.G294G|DIDO1_uc002ydv.1_Silent_p.G294G|DIDO1_uc002ydw.1_Silent_p.G294G|DIDO1_uc002ydx.1_Silent_p.G294G|DIDO1_uc011aao.1_Silent_p.G294G	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	294	PHD-type.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCACACAATCGCCATGAAACC	0.448	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											23	35					0	0	0.003954	0	0
MN1	4330	broad.mit.edu	37	22	28194109	28194109	+	Missense_Mutation	SNP	C	C	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr22:28194109C>G	uc003adj.2	-	1	3378	c.2423G>C	c.(2422-2424)GGC>GCC	p.G808A		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	808							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GTTGAAGGAGCCCAGCGAGAG	0.677			NA	T	ETV6	AML|meningioma								22	39					0	0	0.001523	0	0
BOD1L	259282	broad.mit.edu	37	4	13604663	13604663	+	Silent	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr4:13604663C>T	uc003gmz.1	-	10	3978	c.3861G>A	c.(3859-3861)GTG>GTA	p.V1287V	BOD1L_uc010idr.1_Silent_p.V624V	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1287							DNA binding			ovary(5)|breast(1)	6						GCACAACAGTCACTGAACTTA	0.448			NA											17	37					0	0	0.004007	0	0
LRRC66	339977	broad.mit.edu	37	4	52861066	52861067	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr4:52861066_52861067CC>AA	uc003gzi.2	-	4	2134_2135	c.2121_2122GG>TT	c.(2119-2124)GAGGGG>GATTGG	p.707_708EG>DW		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	707_708						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						AACAGAGACCCCTCATCAGAGT	0.53			NA											31	61					0	0	0.004672	0	0
TECRL	253017	broad.mit.edu	37	4	65175604	65175604	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr4:65175604C>A	uc003hcv.2	-	6	706	c.597G>T	c.(595-597)TTG>TTT	p.L199F	TECRL_uc003hcw.2_Missense_Mutation_p.L199F	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	199					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						ATAAGGTTTCCAAAAGGTATC	0.338			NA											40	100					1.03484e-13	1.38261e-13	0.005524	1	0
EPHA5	2044	broad.mit.edu	37	4	66201731	66201731	+	Missense_Mutation	SNP	T	T	G			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr4:66201731T>G	uc003hcy.2	-	16	2964	c.2771A>C	c.(2770-2772)AAG>ACG	p.K924T	EPHA5_uc003hcx.2_Missense_Mutation_p.K856T|EPHA5_uc003hcz.2_Missense_Mutation_p.K902T|EPHA5_uc011cah.1_Missense_Mutation_p.K925T|EPHA5_uc011cai.1_Missense_Mutation_p.K903T|EPHA5_uc003hda.2_Missense_Mutation_p.K925T	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	924	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TTCATCAAACTTGGGCCTGCT	0.488			NA								TSP Lung(17;0.13)			14	76					0	0	0.00245	0	0
ANP32C	23520	broad.mit.edu	37	4	165118439	165118439	+	Missense_Mutation	SNP	T	T	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr4:165118439T>A	uc011cjk.1	-	1	425	c.425A>T	c.(424-426)GAC>GTC	p.D142V	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	142											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GTAACAGCTGTCGAGATATGT	0.507			NA											12	126					0	0	0.00245	0	0
SNX24	28966	broad.mit.edu	37	5	122281813	122281813	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr5:122281813G>A	uc011cwo.1	+	3	377	c.208G>A	c.(208-210)GTC>ATC	p.V70I	SNX24_uc003ktf.2_Missense_Mutation_p.V70I|SNX24_uc010jcy.2_Missense_Mutation_p.V70I	NM_014035	NP_054754	Q9Y343	SNX24_HUMAN	SBBI31 protein	70	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		GGTCCCCAAAGTCTTGGAACA	0.323			NA											7	41					0	0	0.004482	0	0
PCDHB18	54660	broad.mit.edu	37	5	140616088	140616088	+	Silent	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr5:140616088C>A	uc003ljc.1	+	1	2151	c.1803C>A	c.(1801-1803)GCC>GCA	p.A601A		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						CGCGCTCGGCCACCGCCACGC	0.716			NA											4	38					1.23904e-05	1.42228e-05	0.000602	1	0
HIST1H3D	8351	broad.mit.edu	37	6	26199202	26199202	+	Translation_Start_Site	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr6:26199202G>A	uc003ngv.2	-	1	263	c.-134C>T	c.(-136--132)AACGA>AATGA		HIST1H2AD_uc003ngw.2_Silent_p.N90N|HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d						blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				GCTCCTCGTCGTTGCGGATGG	0.597	GBM(108;3816 4467)		NA											24	132					0	0	0.005443	0	0
BAI3	577	broad.mit.edu	37	6	69640468	69640468	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr6:69640468G>T	uc003pev.3	+	4	1223	c.775G>T	c.(775-777)GAT>TAT	p.D259Y	BAI3_uc010kak.2_Missense_Mutation_p.D259Y	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	259	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AATGATGGGAGATCATACAAT	0.368			NA											9	23					2.74318e-10	3.46619e-10	0.006214	1	0
GABRR1	2569	broad.mit.edu	37	6	89888768	89888768	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr6:89888768G>T	uc003pna.2	-	10	1616	c.1161C>A	c.(1159-1161)AGC>AGA	p.S387R	GABRR1_uc011dzv.1_Missense_Mutation_p.S364R	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	387	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GAGGTAATCCGCTGGTGCAGG	0.542			NA											11	21					1.08611e-07	1.31137e-07	0.000978	1	0
ZBTB24	9841	broad.mit.edu	37	6	109802316	109802316	+	Missense_Mutation	SNP	T	T	C			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr6:109802316T>C	uc003ptl.1	-	2	1082	c.914A>G	c.(913-915)TAC>TGC	p.Y305C	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.Y305C|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Missense_Mutation_p.Y305C	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	305	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		AAAGTGATTGTACTTAAAGAC	0.473			NA											46	103					0	0	0.00361	0	0
DDO	8528	broad.mit.edu	37	6	110714107	110714107	+	Silent	SNP	A	A	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr6:110714107A>T	uc003puc.2	-	5	985	c.981T>A	c.(979-981)CCT>CCA	p.P327P	C6orf186_uc003pub.2_Intron|DDO_uc003pud.2_Silent_p.P268P	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	299					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GGTGGACTACAGGCAGCCTCT	0.637			NA											28	35					0	0	0.004656	0	0
PKD1L1	168507	broad.mit.edu	37	7	47894610	47894610	+	Missense_Mutation	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr7:47894610C>A	uc003tny.1	-	30	4729	c.4729G>T	c.(4729-4731)GTA>TTA	p.V1577L		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1577	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CGAAGTAATACAAATGTCGTT	0.348			NA											18	60					5.01169e-05	5.67296e-05	0.00499	1	0
TYW1B	441250	broad.mit.edu	37	7	72081774	72081774	+	Silent	SNP	A	A	G	rs3015854	by1000genomes	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr7:72081774A>G	uc011kej.1	-	16	1827	c.1668T>C	c.(1666-1668)CAT>CAC	p.H556H	TYW1B_uc011keh.1_Silent_p.H394H|TYW1B_uc011kei.1_Silent_p.H182H	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	556					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GCCAGGGCACATGGGCCATGG	0.493			NA											7	77					0	0	0.001984	0	0
ACTR3B	57180	broad.mit.edu	37	7	152549330	152549330	+	Silent	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr7:152549330G>A	uc003wle.1	+	10	1188	c.1071G>A	c.(1069-1071)AGG>AGA	p.R357R	ACTR3B_uc003wlf.1_Intron|ACTR3B_uc003wlg.1_Silent_p.R269R|ACTR3B_uc011kvp.1_Silent_p.R269R	NM_020445	NP_065178	Q9P1U1	ARP3B_HUMAN	actin-related protein 3-beta isoform 1	357					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding				0		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		GCGGCGGGAGGATCAAGGTAG	0.637			NA											12	38					0	0	0.001368	0	0
RP1L1	94137	broad.mit.edu	37	8	10470626	10470626	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr8:10470626G>A	uc003wtc.2	-	4	1211	c.982C>T	c.(982-984)CGC>TGC	p.R328C		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	328					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGTGGAAGCGGACTTTCATC	0.657			NA											31	52					0	0	0.001786	0	0
CSMD3	114788	broad.mit.edu	37	8	113694836	113694836	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr8:113694836C>A	uc003ynu.2	-	16	2671	c.2512G>T	c.(2512-2514)GGA>TGA	p.G838*	CSMD3_uc003yns.2_Nonsense_Mutation_p.G110*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.G798*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.G734*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	838	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATTGGTATTCCAGGATCAGGG	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	68					1.17739e-12	1.5477e-12	0.005443	1	0
CCBL1	883	broad.mit.edu	37	9	131605043	131605043	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr9:131605043C>T	uc004bwh.2	-	3	276	c.91G>A	c.(91-93)GTG>ATG	p.V31M	CCBL1_uc004bwf.2_Missense_Mutation_p.V65M|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.V31M|CCBL1_uc004bwj.2_Missense_Mutation_p.V31M|CCBL1_uc011mbl.1_Missense_Mutation_p.V125M|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.V31M	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	31					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	CCCAAGTTCACGACGTCATGC	0.562			NA											21	23					0	0	0.002299	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821243	5821243	+	Silent	SNP	C	C	T	rs9785605		TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:5821243C>T	uc010ndh.2	-	5	1977	c.1476G>A	c.(1474-1476)GAG>GAA	p.E492E	NLGN4X_uc004crp.2_Silent_p.E512E|NLGN4X_uc004crq.2_Silent_p.E492E|NLGN4X_uc010ndi.2_Silent_p.E529E|NLGN4X_uc004crr.2_Silent_p.E492E|NLGN4X_uc010ndj.2_Silent_p.E492E	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	492	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CATAGGGGACCTCATCACCAT	0.557			NA											28	40					0	0	0.004289	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821249	5821249	+	Silent	SNP	A	A	G	rs9785509		TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:5821249A>G	uc010ndh.2	-	5	1971	c.1470T>C	c.(1468-1470)GGT>GGC	p.G490G	NLGN4X_uc004crp.2_Silent_p.G510G|NLGN4X_uc004crq.2_Silent_p.G490G|NLGN4X_uc010ndi.2_Silent_p.G527G|NLGN4X_uc004crr.2_Silent_p.G490G|NLGN4X_uc010ndj.2_Silent_p.G490G	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	490	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GGACCTCATCACCATGGGCCG	0.567			NA											24	38					0	0	0.003271	0	0
MAGEB6	158809	broad.mit.edu	37	X	26211971	26211971	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:26211971G>T	uc004dbr.2	+	2	157	c.8G>T	c.(7-9)CGG>CTG	p.R3L	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	3										ovary(3)	3						ATCATGCCTCGGGGTCACAAG	0.572			NA											16	70					3.32936e-07	3.99033e-07	0.006122	1	0
AR	367	broad.mit.edu	37	X	66863200	66863200	+	Silent	SNP	A	A	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:66863200A>T	uc004dwu.1	+	2	2834	c.1719A>T	c.(1717-1719)GGA>GGT	p.G573G	AR_uc011mpd.1_Silent_p.G573G|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Silent_p.G573G|AR_uc004dwv.1_Silent_p.G41G	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	572	Interaction with HIPK3 (By similarity).|NR C4-type.|Nuclear receptor.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GTCACTATGGAGCTCTCACAT	0.493			NA							Androgen_Insensitivity_Syndrome				21	57					0	0	0.001523	0	0
MED12	9968	broad.mit.edu	37	X	70354597	70354597	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:70354597G>A	uc004dyy.2	+	35	4961	c.4762G>A	c.(4762-4764)GTG>ATG	p.V1588M	MED12_uc011mpq.1_Missense_Mutation_p.V1588M|MED12_uc004dyz.2_Missense_Mutation_p.V1588M|MED12_uc004dza.2_Missense_Mutation_p.V1435M|MED12_uc010nla.2_Missense_Mutation_p.V214M	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1588					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATGCTGAGCGTGCTCATCAA	0.483			NA											36	137					0	0	0.004289	0	0
ATP7A	538	broad.mit.edu	37	X	77286941	77286941	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:77286941G>T	uc004ecx.3	+	16	3315	c.3155G>T	c.(3154-3156)GGA>GTA	p.G1052V		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1052	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						ATTACTCACGGAACCCCAGTG	0.378			NA											91	197					1.78623e-52	2.50996e-52	0.00361	1	0
GPRASP2	114928	broad.mit.edu	37	X	101969872	101969872	+	Silent	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:101969872G>A	uc004ejk.2	+	4	1409	c.75G>A	c.(73-75)GGG>GGA	p.G25G	GPRASP2_uc004ejl.2_Silent_p.G25G|GPRASP2_uc004ejm.2_Silent_p.G25G|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	25						cytoplasm	protein binding			ovary(1)	1						TTATCGCTGGGCCTGAGAGAG	0.483			NA											46	100					0	0	0.002522	0	0
HTR2C	3358	broad.mit.edu	37	X	113965913	113965913	+	Missense_Mutation	SNP	G	G	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:113965913G>T	uc004epu.1	+	4	974	c.246G>T	c.(244-246)AAG>AAT	p.K82N	HTR2C_uc010nqc.1_Missense_Mutation_p.K82N|HTR2C_uc004epv.1_Missense_Mutation_p.K82N	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	82	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	GCATGGAAAAGAAACTGCACA	0.448			NA											4	118					2.56e-06	2.98057e-06	0.000248	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904436	144904436	+	Silent	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:144904436C>T	uc004fcd.2	+	5	1483	c.493C>T	c.(493-495)CTG>TTG	p.L165L	SLITRK2_uc010nsp.2_Silent_p.L165L|SLITRK2_uc010nso.2_Silent_p.L165L|SLITRK2_uc011mwq.1_Silent_p.L165L|SLITRK2_uc011mwr.1_Silent_p.L165L|SLITRK2_uc011mws.1_Silent_p.L165L|SLITRK2_uc004fcg.2_Silent_p.L165L|SLITRK2_uc011mwt.1_Silent_p.L165L	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	165	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					AGTGCTCATCCTGAATGACAA	0.502			NA											45	143					0	0	0.003214	0	0
AFF2	2334	broad.mit.edu	37	X	147924509	147924509	+	Missense_Mutation	SNP	C	C	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:147924509C>T	uc004fcp.2	+	6	1672	c.1193C>T	c.(1192-1194)CCA>CTA	p.P398L	AFF2_uc004fco.2_Missense_Mutation_p.P365L|AFF2_uc004fcq.2_Missense_Mutation_p.P394L|AFF2_uc004fcr.2_Missense_Mutation_p.P365L|AFF2_uc011mxb.1_Missense_Mutation_p.P369L|AFF2_uc004fcs.2_Missense_Mutation_p.P365L|AFF2_uc011mxc.1_Missense_Mutation_p.P39L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	398					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CATCTGACCCCAGGATTCACC	0.348			NA											36	145					0	0	0.003271	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696766	153696766	+	Missense_Mutation	SNP	G	G	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:153696766G>A	uc004flm.2	+	23	4257	c.4084G>A	c.(4084-4086)GGC>AGC	p.G1362S		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1362	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCGCGACCGCGGCACCGTGGC	0.667			NA											6	34					0	0	0.001168	0	0
RIT1	6016	broad.mit.edu	37	1	155874531	155874532	+	In_Frame_Ins	INS	-	-	GTATCCAAA			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr1:155874531_155874532insGTATCCAAA	uc001fmh.1	-	4	414_415	c.227_228insTTTGGATAC	c.(226-228)ACA>ACTTTGGATACA	p.76_76T>TLDT	RIT1_uc010pgr.1_In_Frame_Ins_p.40_40T>TLDT	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	76	GTP (By similarity).				nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			CCTGTCCAGCTGTATCCAAAAT	0.401			NA											14	76	---	---	---	---	NA	NA	NA	NA	NA
RUFY2	55680	broad.mit.edu	37	10	70156583	70156583	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr10:70156583delT	uc001job.2	-	4	784	c.457delA	c.(457-459)ATGfs	p.M153fs	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Frame_Shift_Del_p.M60fs|RUFY2_uc001jod.1_Frame_Shift_Del_p.M118fs|RUFY2_uc009xpv.1_Frame_Shift_Del_p.M1fs|RUFY2_uc001joe.1_Frame_Shift_Del_p.M118fs	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	167	RUN.					nucleus	metal ion binding			ovary(1)	1						TAATCGGCCATTTTTTTTTGC	0.398			NA											8	86	---	---	---	---	NA	NA	NA	NA	NA
LOC653544	653544	broad.mit.edu	37	10	135491036	135491036	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr10:135491036delG	uc010qvi.1	+	1	758	c.647delG	c.(646-648)AGGfs	p.R216fs		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	216						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGGGTGGCAGGGCGCCCGCG	0.736			NA											7	269	---	---	---	---	NA	NA	NA	NA	NA
ZDHHC13	54503	broad.mit.edu	37	11	19184974	19184974	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:19184974delG	uc001mpi.2	+	11	1338	c.1233delG	c.(1231-1233)GTGfs	p.V411fs	ZDHHC13_uc001mpj.2_Frame_Shift_Del_p.V281fs	NM_019028	NP_061901	Q8IUH4	ZDH13_HUMAN	zinc finger, DHHC domain containing 13 isoform	411					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding				0						AAAAGAAAGTGGTGAGATTTC	0.358			NA											15	31	---	---	---	---	NA	NA	NA	NA	NA
CHEK1	1111	broad.mit.edu	37	11	125505377	125505378	+	Frame_Shift_Ins	INS	-	-	A	rs35817404		TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr11:125505377_125505378insA	uc009zbo.2	+	7	1559_1560	c.667_668insA	c.(667-669)GAAfs	p.E223fs	CHEK1_uc010sbh.1_Frame_Shift_Ins_p.E239fs|CHEK1_uc010sbi.1_Frame_Shift_Ins_p.E223fs|CHEK1_uc001qcf.3_Frame_Shift_Ins_p.E223fs|CHEK1_uc009zbp.2_Frame_Shift_Ins_p.E223fs|CHEK1_uc001qcg.3_Frame_Shift_Ins_p.E223fs|CHEK1_uc009zbq.2_Frame_Shift_Ins_p.E223fs|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	223	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		TGACTGGAAAGAAAAAAAAACA	0.361			NA						Other_conserved_DNA_damage_response_genes					7	134	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	12	31270080	31270081	+	In_Frame_Ins	INS	-	-	AAA	rs112314315		TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr12:31270080_31270081insAAA	uc010sjy.1	-	28	3788_3789	c.3788_3789insTTT	c.(3787-3789)ATC>ATTTTC	p.1263_1264insF	uc001rjy.2_Intron|uc001rjz.2_Intron					RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						CGTTAAACTGGATCTCACTGGA	0.505			NA											8	20	---	---	---	---	NA	NA	NA	NA	NA
SLITRK5	26050	broad.mit.edu	37	13	88328297	88328297	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr13:88328297delG	uc001vln.2	+	2	873	c.654delG	c.(652-654)GTGfs	p.V218fs	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	218	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TGCCCTACGTGGGGCTCTTGC	0.483			NA											36	58	---	---	---	---	NA	NA	NA	NA	NA
JPH4	84502	broad.mit.edu	37	14	24040435	24040436	+	Frame_Shift_Ins	INS	-	-	C	rs144738828	byFrequency	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr14:24040435_24040436insC	uc001wkq.2	-	6	2422_2423	c.1504_1505insG	c.(1504-1506)GCAfs	p.A502fs	JPH4_uc010tnr.1_Frame_Shift_Ins_p.A167fs|JPH4_uc001wkr.2_Frame_Shift_Ins_p.A502fs	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	502	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane		p.A502fs*12(1)		ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CTGTGCGCCTGCCCCCCCCCAC	0.688			NA											8	179	---	---	---	---	NA	NA	NA	NA	NA
KBTBD10	10324	broad.mit.edu	37	2	170366496	170366496	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr2:170366496delA	uc002ueu.1	+	1	285	c.208delA	c.(208-210)AAAfs	p.K70fs	KBTBD10_uc010zdh.1_Intron	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	70	BTB.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						TGATGAGGCGAAAAAAAAGGA	0.388			NA											8	135	---	---	---	---	NA	NA	NA	NA	NA
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs150114751	byFrequency	TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	TCG	TCG	-	-	TCG	TCG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr3:137880741_137880743delTCG	uc003erv.2	-	8	1759_1761	c.1623_1625delCGA	c.(1621-1626)GATGAT>GAT	p.541_542DD>D	DBR1_uc003eru.2_In_Frame_Del_p.490_491DD>D|DBR1_uc003ert.2_In_Frame_Del_p.309_310DD>D	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	541_542						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						TTAAGCTGCATCGTCATCATCAT	0.251			NA											7	105	---	---	---	---	NA	NA	NA	NA	NA
ATR	545	broad.mit.edu	37	3	142274739	142274740	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr3:142274739_142274740insT	uc003eux.3	-	10	2442_2443	c.2320_2321insA	c.(2320-2322)ATAfs	p.I774fs		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	774					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TGGACTAGGTATTTTTTTTTTC	0.332			NA						Other_conserved_DNA_damage_response_genes					10	128	---	---	---	---	NA	NA	NA	NA	NA
UGDH	7358	broad.mit.edu	37	4	39515752	39515753	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr4:39515752_39515753insA	uc003guk.1	-	3	530_531	c.214_215insT	c.(214-216)TCTfs	p.S72fs	UGDH_uc011byp.1_5'UTR|UGDH_uc003gul.1_Frame_Shift_Ins_p.S72fs	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	72					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	AATATTGGTAGAAAAAAAAAGA	0.297			NA											8	196	---	---	---	---	NA	NA	NA	NA	NA
HLA-F	3134	broad.mit.edu	37	6	29694802	29694803	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr6:29694802_29694803insT	uc003nno.3	+	7	1303_1304	c.1179_1180insT	c.(1177-1182)TTGTTTfs	p.L393fs	HLA-F_uc011dlx.1_Intron|HLA-F_uc011dly.1_Intron|LOC285830_uc003nnp.2_RNA|LOC285830_uc011dlz.1_RNA	NM_001098479	NP_001091949	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	Error:Variant_position_missing_in_P30511_after_alignment					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						TGTGGATCTTGTTTTTTTTGTG	0.535			NA											10	346	---	---	---	---	NA	NA	NA	NA	NA
ABCF1	23	broad.mit.edu	37	6	30545854	30545854	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr6:30545854delA	uc003nql.2	+	4	313	c.218delA	c.(217-219)CAAfs	p.Q73fs	ABCF1_uc003nqk.2_Frame_Shift_Del_p.Q74fs|ABCF1_uc003nqm.2_Frame_Shift_Del_p.Q73fs|ABCF1_uc010jsb.2_Frame_Shift_Del_p.Q73fs	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	73					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						TCTCAGCAGCAAAAAAAAAAG	0.493			NA											10	82	---	---	---	---	NA	NA	NA	NA	NA
KCND2	3751	broad.mit.edu	37	7	120385968	120385969	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chr7:120385968_120385969insA	uc003vjj.1	+	5	2567_2568	c.1602_1603insA	c.(1600-1605)CACAAAfs	p.H534fs		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	534_535	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CACGACGACACAAAAAAACTTT	0.45			NA											11	119	---	---	---	---	NA	NA	NA	NA	NA
ARMCX3	51566	broad.mit.edu	37	X	100880216	100880216	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-6779-01A-11D-1855-08	TCGA-44-6779-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d6990a90-6a99-490b-a476-5298f0c4e4f2	84e9ba6c-a60a-48df-8176-1a06bda173f0	g.chrX:100880216delG	uc004ehz.1	+	5	780	c.247delG	c.(247-249)GGGfs	p.G83fs	ARMCX3_uc004eia.1_Frame_Shift_Del_p.G83fs|ARMCX3_uc004eib.1_Frame_Shift_Del_p.G83fs|ARMCX3_uc004eic.1_Frame_Shift_Del_p.G83fs	NM_016607	NP_057691	Q9UH62	ARMX3_HUMAN	armadillo repeat containing, X-linked 3	83						integral to membrane	binding			ovary(1)|lung(1)	2						GGCTCGGATTGGGACTGAAGC	0.458			NA											25	157	---	---	---	---	NA	NA	NA	NA	NA
