Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11270918	11270918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:11270918G>A	uc001asd.2	-	24	3728	c.3607C>T	c.(3607-3609)CGA>TGA	p.R1203*		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1203					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TGATTGATTCGGTGTCGCACC	0.393			NA											5	75					0	0	0.02938	0	0
C1orf64	149563	broad.mit.edu	37	1	16330828	16330828	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:16330828G>T	uc001axn.2	+	1	98	c.30G>T	c.(28-30)TGG>TGT	p.W10C		NM_178840	NP_849162	Q8NEQ6	CA064_HUMAN	hypothetical protein LOC149563	10										breast(2)	2		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGGACTGGAGAGCCAACC	0.637			NA											4	8					0.00024832	0.000269454	0.009096	1	0
HSP90B3P	343477	broad.mit.edu	37	1	92108525	92108525	+	Nonsense_Mutation	SNP	C	C	A	rs117857370	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:92108525C>A	uc010osx.1	+	3	552	c.552C>A	c.(550-552)TAC>TAA	p.Y184*		NR_003130				SubName: Full=cDNA FLJ58812, highly similar to Endoplasmin (Heat shock protein 90kDa beta member 1);												0						TGCCTAAGTACCTTAATTTTG	0.378			NA											12	23					0.000978159	0.00103929	0.010729	1	0
SELENBP1	8991	broad.mit.edu	37	1	151341499	151341499	+	Missense_Mutation	SNP	C	C	A	rs150747769	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:151341499C>A	uc001exx.2	-	4	388	c.341G>T	c.(340-342)CGG>CTG	p.R114L	SELENBP1_uc010pcy.1_Missense_Mutation_p.R156L|SELENBP1_uc001exy.2_Missense_Mutation_p.G10W|SELENBP1_uc001exz.2_Missense_Mutation_p.G10W|SELENBP1_uc010pcz.1_Intron|SELENBP1_uc009wms.2_Missense_Mutation_p.G10W|SELENBP1_uc009wmt.2_Missense_Mutation_p.G10W|SELENBP1_uc001eya.2_Missense_Mutation_p.R50L|SELENBP1_uc009wmu.2_Missense_Mutation_p.G10W	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	114				RAP -> GPQ (in Ref. 1; AAB02395).	protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTTTGGGGCCCGGGGCTCAGA	0.607			NA											16	76					6.31663e-08	7.71612e-08	0.024245	1	0
TDRKH	11022	broad.mit.edu	37	1	151755442	151755442	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:151755442C>A	uc009wnb.1	-	2	239	c.57G>T	c.(55-57)CTG>CTT	p.L19L	TDRKH_uc001eyy.2_5'UTR|TDRKH_uc001ezb.3_Silent_p.L19L|TDRKH_uc001ezc.3_Silent_p.L19L|TDRKH_uc001eza.3_Silent_p.L19L|TDRKH_uc001ezd.3_Silent_p.L19L|TDRKH_uc010pdn.1_5'UTR	NM_006862	NP_006853	Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing isoform a	19							RNA binding			ovary(1)|pancreas(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCCCAAGGCCCAGGGCTATTT	0.463			NA											39	130					6.57855e-14	9.00687e-14	0.036044	1	0
FLG	2312	broad.mit.edu	37	1	152281717	152281717	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:152281717C>T	uc001ezu.1	-	3	5681	c.5645G>A	c.(5644-5646)GGG>GAG	p.G1882E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1882	Ser-rich.|Filaggrin 11.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGACGCGACCCTGAGTGCCT	0.577			NA							Ichthyosis				98	456					0	0	0.048971	0	0
NTRK1	4914	broad.mit.edu	37	1	156845419	156845419	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:156845419G>A	uc001fqh.1	+	12	1518	c.1462G>A	c.(1462-1464)GGC>AGC	p.G488S	NTRK1_uc001fqf.1_Missense_Mutation_p.G452S|NTRK1_uc009wsi.1_Missense_Mutation_p.G187S|NTRK1_uc001fqi.1_Missense_Mutation_p.G482S|NTRK1_uc009wsk.1_Missense_Mutation_p.G482S	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	488	Cytoplasmic (Potential).|Interaction with SQSTM1 (By similarity).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGGGCTCCAAGGCCACATCAT	0.517			NA	T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			22	58					0	0	0.01892	0	0
SPTA1	6708	broad.mit.edu	37	1	158619707	158619707	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:158619707T>A	uc001fst.1	-	25	3707	c.3508A>T	c.(3508-3510)AGG>TGG	p.R1170W		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1170	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCTGCAAGCCTCTGCAAAGAA	0.458			NA											11	36					0	0	0.024245	0	0
SPTA1	6708	broad.mit.edu	37	1	158623075	158623075	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:158623075C>A	uc001fst.1	-	22	3376	c.3177G>T	c.(3175-3177)CAG>CAT	p.Q1059H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1059					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GGTTCTCAATCTGCTCCTGGC	0.517			NA											34	160					6.04917e-29	9.64087e-29	0.027894	1	0
UCK2	7371	broad.mit.edu	37	1	165872437	165872437	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:165872437A>T	uc001gdp.2	+	5	699	c.518A>T	c.(517-519)GAG>GTG	p.E173V	UCK2_uc010plb.1_Missense_Mutation_p.E35V	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	173					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GACATCAGCGAGAGAGGCAGG	0.483			NA											7	150					0	0	0.047766	0	0
C1orf49	84066	broad.mit.edu	37	1	178485002	178485002	+	Silent	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:178485002C>G	uc001glt.1	+	4	280	c.168C>G	c.(166-168)CTC>CTG	p.L56L	C1orf49_uc001glu.1_Silent_p.L56L|C1orf49_uc001glv.1_RNA|C1orf49_uc001glw.1_Silent_p.L64L	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	56	Potential.					microtubule cytoskeleton					0						AGAATGAACTCAGGGAAGTGA	0.433			NA											12	24					0	0	0.024245	0	0
SMG7	9887	broad.mit.edu	37	1	183515445	183515445	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:183515445G>T	uc001gqg.2	+	17	2837	c.2715G>T	c.(2713-2715)CAG>CAT	p.Q905H	SMG7_uc010pob.1_Missense_Mutation_p.Q888H|SMG7_uc001gqf.2_Missense_Mutation_p.Q859H|SMG7_uc001gqh.2_Missense_Mutation_p.Q859H|SMG7_uc001gqi.2_Missense_Mutation_p.Q817H|SMG7_uc010poc.1_Missense_Mutation_p.Q863H	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	905					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GTCCAGAGCAGGATCCTGTAC	0.473			NA											22	62					1.36565e-18	1.98994e-18	0.016522	1	0
CRB1	23418	broad.mit.edu	37	1	197397003	197397003	+	Missense_Mutation	SNP	G	G	A	rs62636270		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:197397003G>A	uc001gtz.2	+	7	2683	c.2548G>A	c.(2548-2550)GGC>AGC	p.G850S	CRB1_uc010poz.1_Missense_Mutation_p.G781S|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.G738S|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.G331S|CRB1_uc001gub.1_Missense_Mutation_p.G499S	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	850	Extracellular (Potential).|Laminin G-like 2.		G -> S (in RP12).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ATTCTTCAAAGGCTGTATCCA	0.393			NA											17	65					0	0	0.028581	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205308439	205308439	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:205308439A>C	uc001hcf.1	-	4	1208	c.640T>G	c.(640-642)TTC>GTC	p.F214V	KLHDC8A_uc010prg.1_Missense_Mutation_p.F101V|KLHDC8A_uc001hcg.1_Missense_Mutation_p.F214V	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	214	Kelch 5.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			AAGCTGGAGAAGGCCCGCTTA	0.582			NA											11	41					0	0	0.016723	0	0
SLC35F3	148641	broad.mit.edu	37	1	234455930	234455930	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:234455930G>T	uc001hwa.1	+	6	1255	c.1027G>T	c.(1027-1029)GCA>TCA	p.A343S	SLC35F3_uc001hvy.1_Missense_Mutation_p.A412S	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	343	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			ACCTGTGAATGCAGGTAAACC	0.259			NA											17	82					3.51602e-12	4.71886e-12	0.049695	1	0
OR11L1	391189	broad.mit.edu	37	1	248004356	248004356	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248004356G>T	uc001idn.1	-	1	843	c.843C>A	c.(841-843)GTC>GTA	p.V281V		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCAGTGGTGTGACCACAGTGT	0.443			NA											20	88					3.62473e-10	4.59283e-10	0.012319	1	0
OR2L2	26246	broad.mit.edu	37	1	248201637	248201637	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248201637G>T	uc001idw.2	+	1	164	c.68G>T	c.(67-69)GGC>GTC	p.G23V	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	23	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCAAGAATTGGCCTTTTCGTA	0.388			NA											45	185					9.84934e-19	1.45599e-18	0.039052	1	0
OR2L3	391192	broad.mit.edu	37	1	248224693	248224693	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248224693A>G	uc001idx.1	+	1	710	c.710A>G	c.(709-711)TAC>TGC	p.Y237C	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	237	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AAGAAAGCCTACCTGACCTGC	0.473			NA											130	172					0	0	0.048971	0	0
OR2M5	127059	broad.mit.edu	37	1	248308583	248308583	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248308583T>C	uc010pze.1	+	1	134	c.134T>C	c.(133-135)ATG>ACG	p.M45T		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			AACTCTGTCATGGTTCTCCTC	0.522			NA											183	230					0	0	0.048971	0	0
FAM171A1	221061	broad.mit.edu	37	10	15263031	15263031	+	Silent	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:15263031A>T	uc001iob.2	-	6	790	c.783T>A	c.(781-783)CTT>CTA	p.L261L		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	261	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						CCTGGTGCACAAGACCCAGAC	0.552			NA											32	63					0	0	0.045705	0	0
CUBN	8029	broad.mit.edu	37	10	17156057	17156057	+	Silent	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:17156057T>C	uc001ioo.2	-	8	904	c.852A>G	c.(850-852)CAA>CAG	p.Q284Q		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	284	EGF-like 3; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAAAGAGCCTTGAGTGTTGA	0.562			NA											4	16					0	0	0.009096	0	0
TET1	80312	broad.mit.edu	37	10	70360780	70360780	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:70360780A>G	uc001jok.3	+	3	2462	c.1957A>G	c.(1957-1959)AAA>GAA	p.K653E		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	653	Sufficient for binding to genomic CpG islands.				DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						AAAGAAGCCCAAAGTTTTAAA	0.308			NA											18	61					0	0	0.055883	0	0
HKDC1	80201	broad.mit.edu	37	10	71026381	71026382	+	Nonsense_Mutation	DNP	GC	GC	TT			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:71026381_71026382GC>TT	uc001jpf.3	+	18	2755_2756	c.2622_2623GC>TT	c.(2620-2625)TTGCAG>TTTTAG	p.874_875LQ>F*	HKDC1_uc010qje.1_Nonsense_Mutation_p.737_738LQ>F*|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	874_875					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						CTAGAATATTGCAGGAAACTGT	0.401			NA											25	88					0	0	0.004672	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118203905	118203905	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:118203905G>A	uc001lcl.3	+	4	437	c.336G>A	c.(334-336)CAG>CAA	p.Q112Q		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	112					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		TGTTGCTACAGCTGGAAGATA	0.358			NA											9	38					0	0	0.047766	0	0
TACC2	10579	broad.mit.edu	37	10	123997538	123997538	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:123997538A>T	uc001lfv.2	+	18	8694	c.8334A>T	c.(8332-8334)GAA>GAT	p.E2778D	TACC2_uc001lfw.2_Missense_Mutation_p.E924D|TACC2_uc009xzx.2_Missense_Mutation_p.E2656D|TACC2_uc010qtv.1_Missense_Mutation_p.E2705D|TACC2_uc001lfx.2_Missense_Mutation_p.E405D|TACC2_uc001lfy.2_Missense_Mutation_p.E401D|TACC2_uc001lfz.2_Missense_Mutation_p.E856D|TACC2_uc001lga.2_Missense_Mutation_p.E826D|TACC2_uc009xzy.2_Missense_Mutation_p.E838D|TACC2_uc001lgb.2_Missense_Mutation_p.E736D	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2778	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCAGGCGGGAAGTGATGGAAA	0.473			NA											9	25					0	0	0.008291	0	0
LOC653544	653544	broad.mit.edu	37	10	135491123	135491123	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:135491123G>A	uc010qvi.1	+	1	845	c.734G>A	c.(733-735)GGC>GAC	p.G245D		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCACACCGGCGCGTGGGGA	0.786			NA											7	35					0	0	0.0333	0	0
OR51S1	119692	broad.mit.edu	37	11	4869599	4869599	+	Silent	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:4869599A>G	uc010qyo.1	-	1	840	c.840T>C	c.(838-840)CAT>CAC	p.H280H		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	280	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGAAGAGTATGGGTATGCT	0.448			NA											34	87					0	0	0.054565	0	0
OR51G2	81282	broad.mit.edu	37	11	4936874	4936874	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:4936874C>A	uc001lzr.1	-	1	20	c.20G>T	c.(19-21)GGA>GTA	p.G7V		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTGCTGTTTCCCAGGGATCC	0.547			NA											18	43					5.3912e-06	6.17868e-06	0.038395	1	0
USP47	55031	broad.mit.edu	37	11	11964407	11964407	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:11964407A>T	uc001mjq.1	+	21	3662	c.2899A>T	c.(2899-2901)AGC>TGC	p.S967C	USP47_uc001mjr.2_Missense_Mutation_p.S879C|USP47_uc001mjs.2_Missense_Mutation_p.S947C|USP47_uc001mjt.1_Missense_Mutation_p.S253C	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	967					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		CTCCAGTCATAGCAGTGATAC	0.403			NA											27	91					0	0	0.027356	0	0
KCNA4	3739	broad.mit.edu	37	11	30034020	30034020	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:30034020C>A	uc001msk.2	-	2	1358	c.206G>T	c.(205-207)GGG>GTG	p.G69V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	69						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGTACAGGCCCCGCGTGACTG	0.657			NA											20	49					8.10497e-08	9.84175e-08	0.055883	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735796	55735796	+	Silent	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:55735796A>G	uc010rit.1	-	1	144	c.144T>C	c.(142-144)ACT>ACC	p.T48T		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	48	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AATACATGGGAGTCTGGAGAG	0.338			NA											6	113					0	0	0.021553	0	0
OR5R1	219479	broad.mit.edu	37	11	56185334	56185334	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:56185334G>T	uc010rji.1	-	1	375	c.375C>A	c.(373-375)GCC>GCA	p.A125A		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GACTACAGATGGCGACATAGC	0.468			NA											15	74					2.32078e-09	2.90454e-09	0.024245	1	0
ZP1	22917	broad.mit.edu	37	11	60642986	60642986	+	Splice_Site	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:60642986G>C	uc001nqd.2	+	12	1795	c.1775_splice	c.e12-1	p.D592_splice	ZP1_uc001nqe.2_Splice_Site_p.D299_splice	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor						single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						CTCTCTGACAGACTCCAATGG	0.592			NA											8	23					0	0	0.006214	0	0
DAK	26007	broad.mit.edu	37	11	61109956	61109956	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:61109956C>T	uc001nre.2	+	8	936	c.679C>T	c.(679-681)CGC>TGC	p.R227C	DDB1_uc010rlf.1_5'UTR|DAK_uc009ynm.1_Missense_Mutation_p.R157C	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	227	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						AGCTGGTGTGCGCCGGATAAA	0.592			NA											19	88					0	0	0.038395	0	0
MLL	4297	broad.mit.edu	37	11	118339515	118339515	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:118339515C>T	uc001pta.2	+	2	481	c.458C>T	c.(457-459)TCA>TTA	p.S153L	MLL_uc001ptb.2_Missense_Mutation_p.S153L|MLL_uc001psz.1_Missense_Mutation_p.S186L|MLL_uc001ptd.1_5'UTR	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	153					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GGTTTTGGCTCAGATGAAGAA	0.403			NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								22	51					0	0	0.014323	0	0
GALNT8	26290	broad.mit.edu	37	12	4881631	4881631	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:4881631A>C	uc001qne.1	+	11	1874	c.1782A>C	c.(1780-1782)AGA>AGC	p.R594S		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	594	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						TCATAAACAGAGATACCAAGC	0.522	Colon(108;631 1558 7270 20097 39846)		NA											21	57					0	0	0.055883	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	20					2.0095e-06	2.3425e-06	0.02938	1	0
FAIM2	23017	broad.mit.edu	37	12	50264295	50264295	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:50264295G>C	uc001rvj.1	-	12	1088	c.943C>G	c.(943-945)CGA>GGA	p.R315G	FAIM2_uc001rvi.1_Missense_Mutation_p.R269G|FAIM2_uc001rvk.1_RNA	NM_012306	NP_036438	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	315					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|ovary(1)|skin(1)	3						CCTCATTCTCGGTTAGTGCCA	0.537			NA											25	64					0	0	0.024334	0	0
CBX5	23468	broad.mit.edu	37	12	54645824	54645824	+	Splice_Site	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:54645824C>T	uc001sfh.3	-	3	642	c.324_splice	c.e3+1	p.E108_splice	CBX5_uc001sfk.3_Splice_Site_p.E108_splice|CBX5_uc001sfi.3_Splice_Site_p.E108_splice|CBX5_uc001sfj.3_Splice_Site_p.E108_splice	NM_001127322	NP_001120794	P45973	CBX5_HUMAN	heterochromatin protein 1-alpha						blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding				0						AGGAAGCTTACCTCTCTCTTT	0.323	Colon(153;588 2459 18334 48613)		NA											26	131					0	0	0.030593	0	0
RAB3IP	117177	broad.mit.edu	37	12	70178569	70178569	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:70178569G>A	uc001svp.2	+	4	1075	c.628G>A	c.(628-630)GAA>AAA	p.E210K	RAB3IP_uc001svl.1_Missense_Mutation_p.E194K|RAB3IP_uc001svm.2_Missense_Mutation_p.E194K|RAB3IP_uc001svn.2_Missense_Mutation_p.E194K|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Missense_Mutation_p.E210K|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_RNA|RAB3IP_uc001svt.2_5'UTR	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	210	Potential.				cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			ACAGGAATTGGAAGAACTCAC	0.343			NA											18	69					0	0	0.049695	0	0
SLC17A8	246213	broad.mit.edu	37	12	100806591	100806591	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:100806591G>A	uc010svi.1	+	10	1543	c.1230G>A	c.(1228-1230)TCG>TCA	p.S410S	SLC17A8_uc009ztx.2_Silent_p.S360S	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	410	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TTGGCTTTTCGCATACCAAAG	0.448			NA											31	116					0	0	0.025465	0	0
STAB2	55576	broad.mit.edu	37	12	104077048	104077048	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:104077048C>A	uc001tjw.2	+	26	3057	c.2871C>A	c.(2869-2871)TGC>TGA	p.C957*		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	957	Extracellular (Potential).|EGF-like 10.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TAACTTCATGCTTGGAACAAA	0.323			NA											26	62					1.30897e-18	1.92108e-18	0.041601	1	0
ALKBH2	121642	broad.mit.edu	37	12	109530431	109530431	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:109530431C>G	uc001tnx.2	-	2	554	c.161G>C	c.(160-162)GGC>GCC	p.G54A	ALKBH2_uc001tny.2_Missense_Mutation_p.G54A|ALKBH2_uc010sxj.1_Missense_Mutation_p.G54A|ALKBH2_uc009zvd.2_Missense_Mutation_p.G54A|ALKBH2_uc010sxk.1_Missense_Mutation_p.G54A	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	54					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	CCAGCTAGGGCCTGCTGAGTG	0.567			NA						Direct_reversal_of_damage					30	114					0	0	0.037714	0	0
OAS1	4938	broad.mit.edu	37	12	113357335	113357335	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:113357335G>A	uc001tud.2	+	6	1286	c.1180G>A	c.(1180-1182)GAC>AAC	p.D394N	OAS1_uc001tuc.2_Missense_Mutation_p.G361E|OAS1_uc009zwf.2_Intron	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	394					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						GGCAGAAGAGGACTGGACCTG	0.363			NA											14	69					0	0	0.028581	0	0
STARD13	90627	broad.mit.edu	37	13	33701594	33701594	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:33701594A>T	uc001uuw.2	-	6	1964	c.1838T>A	c.(1837-1839)CTG>CAG	p.L613Q	STARD13_uc001uuu.2_Missense_Mutation_p.L605Q|STARD13_uc001uuv.2_Missense_Mutation_p.L495Q|STARD13_uc001uux.2_Missense_Mutation_p.L578Q|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.L598Q	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	613					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GAGCAGGCTCAGCTGGCTGGC	0.627			NA											10	16					0	0	0.006214	0	0
NBEA	26960	broad.mit.edu	37	13	36167537	36167537	+	Missense_Mutation	SNP	G	G	A	rs116439886	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:36167537G>A	uc001uvb.2	+	47	7455	c.7249G>A	c.(7249-7251)GTT>ATT	p.V2417I	NBEA_uc010abi.2_Missense_Mutation_p.V1073I|NBEA_uc010tee.1_Missense_Mutation_p.V210I|NBEA_uc010tef.1_Missense_Mutation_p.V210I|NBEA_uc010teg.1_Missense_Mutation_p.V210I|NBEA_uc001uvd.2_5'UTR	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2417	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTCTCATCCGTTGCAAGGTC	0.338			NA											17	67					0	0	0.038395	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768338	41768338	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:41768338C>T	uc001uxw.1	-	1	365	c.56G>A	c.(55-57)GGG>GAG	p.G19E	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	19							protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GGGCCGCCTCCCACCACGGGG	0.657			NA											7	118					0	0	0.02938	0	0
KLF12	11278	broad.mit.edu	37	13	74387411	74387411	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:74387411G>A	uc001vjf.2	-	5	906	c.684C>T	c.(682-684)CCC>CCT	p.P228P	KLF12_uc010aeq.2_Silent_p.P228P|KLF12_uc001vjg.3_Silent_p.P228P	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	228					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		ATAGGCCTCGGGGGTCCATTT	0.428			NA											40	83					0	0	0.042209	0	0
OR4N2	390429	broad.mit.edu	37	14	20296223	20296223	+	Missense_Mutation	SNP	A	A	G	rs79084933		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:20296223A>G	uc010tkv.1	+	1	616	c.616A>G	c.(616-618)ATG>GTG	p.M206V		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAGTGGCCTGATGACACTCCT	0.522			NA											36	161					0	0	0.015359	0	0
TEP1	7011	broad.mit.edu	37	14	20849819	20849819	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:20849819C>A	uc001vxe.2	-	31	4491	c.4451G>T	c.(4450-4452)CGC>CTC	p.R1484L	TEP1_uc010ahk.2_Missense_Mutation_p.R827L|TEP1_uc010tlf.1_Intron|TEP1_uc010tlg.1_Missense_Mutation_p.R1376L|TEP1_uc010tlh.1_Intron	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1484	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGCACCAGGGCGCTCCAGAGG	0.617			NA											30	52					7.26314e-15	1.02185e-14	0.034045	1	0
MYH7	4625	broad.mit.edu	37	14	23900847	23900847	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:23900847G>C	uc001wjx.2	-	8	785	c.679C>G	c.(679-681)CTG>GTG	p.L227V		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	227	Myosin head-like.		L -> V (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AAGGCCTCCAGAGCAGGGTTG	0.607			NA											34	124					0	0	0.054565	0	0
MAX	4149	broad.mit.edu	37	14	65560493	65560493	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:65560493C>A	uc001xif.1	-	3	274	c.104G>T	c.(103-105)CGT>CTT	p.R35L	MAX_uc001xic.1_Missense_Mutation_p.R35L|MAX_uc001xie.1_Missense_Mutation_p.R35L|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Missense_Mutation_p.R26L|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Missense_Mutation_p.R26L|MAX_uc001xij.1_Missense_Mutation_p.R35L|MAX_uc001xik.2_Missense_Mutation_p.R35L	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	35	Basic motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GTGGTCCCTACGTTTTCGTTC	0.478			NA											25	42					2.48779e-11	3.29552e-11	0.027356	1	0
ACTN1	87	broad.mit.edu	37	14	69376758	69376758	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:69376758C>G	uc001xkl.2	-	5	739	c.429G>C	c.(427-429)GAG>GAC	p.E143D	ACTN1_uc010ttb.1_Missense_Mutation_p.E78D|ACTN1_uc001xkm.2_Missense_Mutation_p.E143D|ACTN1_uc001xkn.2_Missense_Mutation_p.E143D|ACTN1_uc001xko.1_Missense_Mutation_p.E78D|ACTN1_uc010ttd.1_Missense_Mutation_p.E122D	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	143	Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TGGCTGAAGTCTCTATGGGGA	0.572			NA											16	17					0	0	0.0333	0	0
HHIPL1	84439	broad.mit.edu	37	14	100118894	100118894	+	Missense_Mutation	SNP	G	G	A	rs145984890		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:100118894G>A	uc010avs.2	+	2	654	c.589G>A	c.(589-591)GTG>ATG	p.V197M	HHIPL1_uc001ygl.1_Missense_Mutation_p.V197M	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	197					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				GCGCAACCCCGTGGCCATGGT	0.667			NA											3	36					0	0	0.004672	0	0
OR4M2	390538	broad.mit.edu	37	15	22369056	22369056	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:22369056G>T	uc010tzu.1	+	1	481	c.481G>T	c.(481-483)GCT>TCT	p.A161S	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CATACAGGTGGCTCTCATTGT	0.517			NA											55	263					2.76378e-25	4.2713e-25	0.048971	1	0
C15orf41	84529	broad.mit.edu	37	15	37100595	37100595	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:37100595A>G	uc001zje.3	+	11	1037	c.787A>G	c.(787-789)ATC>GTC	p.I263V	C15orf41_uc001zjd.2_Missense_Mutation_p.I263V|C15orf41_uc010bbb.1_Missense_Mutation_p.I165V|C15orf41_uc001zjf.2_Missense_Mutation_p.I165V|C15orf41_uc010uci.1_Missense_Mutation_p.I165V|CSNK1A1P_uc001zjg.3_Intron	NM_001130010	NP_001123482	Q9Y2V0	CO041_HUMAN	hypothetical protein LOC84529 isoform 1	263							protein binding			pancreas(1)	1		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)		GGAAAGGGGCATCCTGCTCAA	0.478			NA											11	38					0	0	0.008291	0	0
CHST14	113189	broad.mit.edu	37	15	40764364	40764364	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:40764364C>T	uc001zlw.2	+	1	1152	c.952C>T	c.(952-954)CAC>TAC	p.H318Y		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	318	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GGCACCACCTCACGTCCGATT	0.627			NA											22	59					0	0	0.014323	0	0
TGM7	116179	broad.mit.edu	37	15	43577088	43577088	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:43577088C>G	uc001zrf.1	-	7	933	c.928G>C	c.(928-930)GAT>CAT	p.D310H		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	310					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	AAGTTCCTATCCACGTTGTGC	0.433			NA											33	103					0	0	0.050027	0	0
FBN1	2200	broad.mit.edu	37	15	48718047	48718047	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:48718047T>C	uc001zwx.1	-	59	7547	c.7219A>G	c.(7219-7221)AAG>GAG	p.K2407E	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2407	EGF-like 41; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGAATAACCTTGCATTCATCG	0.328			NA											18	37					0	0	0.043863	0	0
SMG1	23049	broad.mit.edu	37	16	18826847	18826847	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:18826847T>C	uc002dfm.2	-	59	10792	c.10429A>G	c.(10429-10431)ATG>GTG	p.M3477V	SMG1_uc010bwb.2_Missense_Mutation_p.M3337V|SMG1_uc010bwa.2_Missense_Mutation_p.M2208V	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3477					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ACCTGACCCATAGCCTGGACT	0.403			NA											28	67					0	0	0.037714	0	0
VWA3A	146177	broad.mit.edu	37	16	22163834	22163834	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:22163834C>A	uc010vbq.1	+	31	3380	c.3284C>A	c.(3283-3285)GCG>GAG	p.A1095E	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_Missense_Mutation_p.A173E|VWA3A_uc010bxe.1_Missense_Mutation_p.A197E	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1095	VWFA 2.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CCTTCCAGAGCGGCGGTTGAG	0.587			NA											7	15					0.000274275	0.000296043	0.047766	1	0
SBK1	388228	broad.mit.edu	37	16	28330438	28330438	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:28330438G>C	uc002dpd.2	+	3	1138	c.349G>C	c.(349-351)GTC>CTC	p.V117L		NM_001024401	NP_001019572	Q52WX2	SBK1_HUMAN	SH3-binding kinase 1	117	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|kidney(1)	2						CTTTGACGTGGTCTTTGAGAC	0.537			NA											21	80					0	0	0.014323	0	0
MAZ	4150	broad.mit.edu	37	16	29821464	29821465	+	Missense_Mutation	DNP	TA	TA	CG			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:29821464_29821465TA>CG	uc002dty.2	+	5	1514_1515	c.1346_1347TA>CG	c.(1345-1347)GTA>GCG	p.V449A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Splice_Site_p.Q86_splice|MAZ_uc010vdx.1_Missense_Mutation_p.V426A|MAZ_uc002dtw.2_Missense_Mutation_p.S104G|MAZ_uc002dtx.2_3'UTR|MAZ_uc010bzg.2_Missense_Mutation_p.V144A|MAZ_uc002dtz.1_3'UTR|MAZ_uc002dua.2_3'UTR|MAZ_uc010vdy.1_Missense_Mutation_p.V50A|uc002duc.1_RNA|PRRT2_uc002dud.2_5'Flank|PRRT2_uc002due.3_5'Flank|PRRT2_uc002duf.1_5'Flank	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	449	Poly-Ala.				regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1						gcggcagcagtagcagcCCCTC	0.465	Colon(72;875 1167 15364 30899 37091)		NA											6	13					0	0	0.004672	0	0
ABCC11	85320	broad.mit.edu	37	16	48234284	48234284	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:48234284G>A	uc002eff.1	-	14	2335	c.1985C>T	c.(1984-1986)TCT>TTT	p.S662F	ABCC11_uc002efg.1_Missense_Mutation_p.S662F|ABCC11_uc002efh.1_Missense_Mutation_p.S662F|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	662	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTCCACAGCAGACAGGGGGTC	0.612			NA							Cerumen_Type				17	57					0	0	0.028581	0	0
PLCG2	5336	broad.mit.edu	37	16	81934352	81934352	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:81934352G>T	uc002fgt.2	+	14	1481	c.1329G>T	c.(1327-1329)TCG>TCT	p.S443S	PLCG2_uc010chg.1_Silent_p.S443S	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	443	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						AGCTGCCCTCGCCCAGCCAGC	0.637			NA											14	27					4.14922e-12	5.53229e-12	0.028581	1	0
NCRNA00188	125144	broad.mit.edu	37	17	16342490	16342490	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:16342490C>T	uc002gqc.2	+	1	190	c.35C>T	c.(34-36)GCA>GTA	p.A12V	NCRNA00188_uc010vwf.1_Intron|NCRNA00188_uc010vwg.1_Intron|NCRNA00188_uc010vwh.1_Intron|NCRNA00188_uc010cpd.2_Intron|NCRNA00188_uc002gqb.3_Intron|NCRNA00188_uc010vwi.1_Intron|NCRNA00188_uc010vwj.1_Intron|NCRNA00188_uc002gqa.3_Intron|NCRNA00188_uc010vwk.1_Intron|NCRNA00188_uc010vwl.1_Intron|NCRNA00188_uc010vwm.1_Intron|NCRNA00188_uc010vwn.1_Intron|NCRNA00188_uc010cpe.2_Intron|NCRNA00188_uc010vwo.1_Intron|NCRNA00188_uc010vwp.1_Intron|SNORD49B_uc010cpf.2_5'Flank|SNORD49A_uc010cpg.1_5'Flank|SNORD65_uc002gqf.1_5'Flank	NR_027667				RecName: Full=Putative uncharacterized protein C17orf45, mitochondrial; Flags: Precursor;												0						GGGCGGAGGGCAGCTGTTGAG	0.667	Pancreas(170;1717 2016 9057 29149 45168)		NA											7	35					0	0	0.047766	0	0
C17orf39	79018	broad.mit.edu	37	17	17948473	17948473	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:17948473G>T	uc002gsg.1	+	2	619	c.451G>T	c.(451-453)GGG>TGG	p.G151W		NM_024052	NP_076957	Q8IVV7	CQ039_HUMAN	hypothetical protein LOC79018	151										skin(1)	1	all_neural(463;0.228)					CGTGGACACGGGGAACTCTTA	0.473			NA											18	36					1.01871e-10	1.30703e-10	0.049695	1	0
LLGL1	3996	broad.mit.edu	37	17	18135839	18135839	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:18135839C>T	uc002gsp.2	+	3	271	c.210C>T	c.(208-210)GGC>GGT	p.G70G		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	70	WD 1.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					AGTTCACAGGCCTGCACCGGG	0.587			NA											6	20					0	0	0.02938	0	0
KIAA0100	9703	broad.mit.edu	37	17	26968943	26968943	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:26968943C>A	uc002hbu.2	-	7	829	c.730G>T	c.(730-732)GGC>TGC	p.G244C	KIAA0100_uc002hbv.2_Missense_Mutation_p.G244C|KIAA0100_uc010crr.1_Missense_Mutation_p.G101C	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	244						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGGCTTGGGCCCTGGCACAGC	0.527			NA											13	48					0.00136819	0.00143872	0.013537	1	0
OMG	4974	broad.mit.edu	37	17	29622866	29622866	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:29622866G>T	uc002hgj.2	-	2	697	c.484C>A	c.(484-486)CCA>ACA	p.P162T	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron	NM_002544	NP_002535	P23515	OMGP_HUMAN	oligodendrocyte myelin glycoprotein precursor	162	LRR 5.				cell adhesion|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;1.81e-13)|Epithelial(4;4.04e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.49e-12)|GBM - Glioblastoma multiforme(4;0.121)		ATGTTGGTTGGAACTGTCCAA	0.383			NA											42	115					6.33695e-27	9.86823e-27	0.030466	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274415	39274415	+	Silent	SNP	C	C	T	rs425487	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:39274415C>T	uc002hvz.2	-	1	192	c.153G>A	c.(151-153)AGG>AGA	p.R51R		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	51	6.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCACTGGGGCCTGCAGCAGC	0.667			NA											7	70					0	0	0.047766	0	0
IMP5	162540	broad.mit.edu	37	17	43922518	43922518	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:43922518C>A	uc010wka.1	+	1	246	c.246C>A	c.(244-246)CGC>CGA	p.R82R	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	82	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		CCCAGCTCCGCTCCCCCAGCC	0.692	NSCLC(24;34 1393 18470)		NA											9	16					0.00448238	0.00468926	0.047766	1	0
CDC27	996	broad.mit.edu	37	17	45219283	45219283	+	Missense_Mutation	SNP	T	T	C	rs76995821		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:45219283T>C	uc002ild.3	-	12	1614	c.1487A>G	c.(1486-1488)TAC>TGC	p.Y496C	CDC27_uc002ile.3_Missense_Mutation_p.Y502C|CDC27_uc002ilf.3_Missense_Mutation_p.Y495C|CDC27_uc010wkp.1_Missense_Mutation_p.Y435C|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	496					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						ACCAGTATTGTAGTGGTGAGA	0.373			NA											46	125					0	0	0.048971	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917306	48917306	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:48917306G>C	uc002isv.3	+	2	1351	c.657G>C	c.(655-657)CAG>CAC	p.Q219H	WFIKKN2_uc010dbu.2_Missense_Mutation_p.Q126H	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	219	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTGTGCACCAGTCGGTCACCA	0.642			NA											11	48					0	0	0.016723	0	0
ATP8B1	5205	broad.mit.edu	37	18	55359055	55359055	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr18:55359055T>A	uc002lgw.2	-	11	1204	c.1204A>T	c.(1204-1206)ATC>TTC	p.I402F	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	402	Helical; (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				TAGAGAGAGATGGGTACCATG	0.443			NA							Byler_disease				16	42					0	0	0.055883	0	0
EEF2	1938	broad.mit.edu	37	19	3982008	3982008	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:3982008G>T	uc002lze.2	-	6	917	c.834C>A	c.(832-834)ACC>ACA	p.T278T		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	278						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCGGGGCTGGTGGCTGACT	0.607	Colon(165;1804 1908 4071 6587 18799)		NA											27	82					4.40665e-25	6.75906e-25	0.041601	1	0
VAV1	7409	broad.mit.edu	37	19	6772930	6772930	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:6772930C>A	uc002mfu.1	+	1	209	c.112C>A	c.(112-114)CGG>AGG	p.R38R	VAV1_uc010xjh.1_Silent_p.R38R|VAV1_uc010dva.1_Silent_p.R38R	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	38	Leu-rich.|CH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCAGGCCCTCCGGGATGGTGT	0.652			NA											19	70					4.96729e-08	6.10438e-08	0.049695	1	0
EMR2	30817	broad.mit.edu	37	19	14875377	14875377	+	Missense_Mutation	SNP	G	G	T	rs150544869		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:14875377G>T	uc002mzp.1	-	11	1408	c.952C>A	c.(952-954)CTG>ATG	p.L318M	EMR2_uc010dzs.1_Translation_Start_Site|EMR2_uc010xnw.1_Missense_Mutation_p.L318M|EMR2_uc002mzo.1_Missense_Mutation_p.L318M|EMR2_uc002mzq.1_Missense_Mutation_p.L269M|EMR2_uc002mzr.1_Missense_Mutation_p.L269M|EMR2_uc002mzs.1_Missense_Mutation_p.L176M|EMR2_uc002mzt.1_Missense_Mutation_p.L225M|EMR2_uc002mzu.1_Missense_Mutation_p.L225M|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	318	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						AGGGTCTCCAGGTCCCCAGGG	0.612			NA											11	49					1.08611e-07	1.30333e-07	0.010729	1	0
ZNF431	170959	broad.mit.edu	37	19	21365588	21365588	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:21365588A>G	uc002npp.2	+	5	629	c.482A>G	c.(481-483)TAT>TGT	p.Y161C	ZNF431_uc010ecq.2_Missense_Mutation_p.Y70C|ZNF431_uc010ecr.2_Missense_Mutation_p.Y162C	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						AAAGAAGGTTATAATGAGCTA	0.328			NA											14	47					0	0	0.020292	0	0
ZNF492	57615	broad.mit.edu	37	19	22847904	22847904	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:22847904A>T	uc002nqw.3	+	4	1677	c.1433A>T	c.(1432-1434)AAG>ATG	p.K478M		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	478	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AAACCCTACAAGTGTGAAGAA	0.388			NA											13	31					0	0	0.016723	0	0
PRX	57716	broad.mit.edu	37	19	40902282	40902282	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:40902282G>A	uc002onr.2	-	7	2246	c.1977C>T	c.(1975-1977)CTC>CTT	p.L659L	PRX_uc002onq.2_Silent_p.L520L|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	659	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGACTTTCGGGAGCTGCACTT	0.562			NA											6	177					0	0	0.021553	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49377008	49377008	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:49377008G>A	uc002pky.3	+	2	787	c.518G>A	c.(517-519)GGA>GAA	p.G173E		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	173	Glu-rich.|Required for localization in the endoplasmic reticulum.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GAAGAGGAGGGAGTTAACAAG	0.527			NA											16	45					0	0	0.024245	0	0
PTH2	113091	broad.mit.edu	37	19	49925835	49925835	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:49925835G>A	uc002pnn.1	-	2	295	c.193C>T	c.(193-195)CTG>TTG	p.L65L		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	65					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		TCGTCCGCCAGCGCCAGGCTC	0.741			NA											6	10					0	0	0.021553	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628630	51628630	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:51628630C>T	uc002pvu.2	+	1	466	c.399C>T	c.(397-399)CAC>CAT	p.H133H	SIGLEC9_uc010yct.1_Silent_p.H133H	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	133	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATAAACATCACCGGCTCTCTG	0.517			NA											14	43					0	0	0.024245	0	0
LILRA4	23547	broad.mit.edu	37	19	54848227	54848227	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:54848227G>T	uc002qfj.2	-	6	1197	c.1140C>A	c.(1138-1140)TTC>TTA	p.F380L	LILRA4_uc002qfi.2_Missense_Mutation_p.F314L	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	380	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GACTCATGGGGAATTCAGCCT	0.607			NA											47	141					5.2432e-18	7.58591e-18	0.048971	1	0
LENG8	114823	broad.mit.edu	37	19	54967251	54967251	+	Silent	SNP	T	T	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:54967251T>G	uc002qfv.1	+	8	1164	c.1020T>G	c.(1018-1020)GGT>GGG	p.G340G	LENG8_uc002qfw.2_Silent_p.G377G			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	340							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GGGGCGGGGGTGCCCCGTCCC	0.687			NA											8	31					0	0	0.010729	0	0
ZNF471	57573	broad.mit.edu	37	19	57037191	57037191	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:57037191C>T	uc002qnh.2	+	5	1888	c.1755C>T	c.(1753-1755)TCC>TCT	p.S585S		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	585	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		ATAGCTCATCCTGTGCTCAGC	0.403	Colon(65;957 1402 6678 10163)|Esophageal Squamous(159;2295 2541 15408 21211)		NA											4	83					0	0	0.009096	0	0
ZNF211	10520	broad.mit.edu	37	19	58152547	58152547	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:58152547G>T	uc002qpq.2	+	3	873	c.693G>T	c.(691-693)TGG>TGT	p.W231C	ZNF211_uc010yhb.1_Missense_Mutation_p.W235C|ZNF211_uc002qpp.2_Missense_Mutation_p.W244C|ZNF211_uc002qpr.2_Missense_Mutation_p.W295C|ZNF211_uc002qps.2_Missense_Mutation_p.W296C|ZNF211_uc002qpt.2_Missense_Mutation_p.W243C|ZNF211_uc010yhc.1_Missense_Mutation_p.W243C|ZNF211_uc010yhd.1_Missense_Mutation_p.W170C|ZNF211_uc010yhe.1_Missense_Mutation_p.W222C	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	231						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCACAACTGGGGAAAATGCA	0.448			NA											31	85					3.99451e-17	5.69846e-17	0.041601	1	0
ATP6V1C2	245973	broad.mit.edu	37	2	10922461	10922461	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:10922461T>A	uc002ras.2	+	13	1263	c.1154T>A	c.(1153-1155)TTC>TAC	p.F385Y	ATP6V1C2_uc002rat.2_Missense_Mutation_p.F339Y	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	385					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		AACTCTGTCTTCCGACATCTG	0.443	NSCLC(188;1042 2136 10807 16813 47705)		NA											15	56					0	0	0.024245	0	0
BCL11A	53335	broad.mit.edu	37	2	60689148	60689148	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:60689148A>T	uc002sae.1	-	4	1127	c.899T>A	c.(898-900)GTG>GAG	p.V300E	BCL11A_uc002sab.2_Missense_Mutation_p.V300E|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.V266E|BCL11A_uc002sad.1_Missense_Mutation_p.V148E|BCL11A_uc002saf.1_Missense_Mutation_p.V266E	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	300	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CAACCGCAGCACCCTGTCAAA	0.612			NA	T	IGH@	B-CLL								22	64					0	0	0.021523	0	0
THNSL2	55258	broad.mit.edu	37	2	88484880	88484880	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:88484880G>T	uc002ssz.3	+	8	1264	c.1111G>T	c.(1111-1113)GAT>TAT	p.D371Y	THNSL2_uc002ssv.2_Intron|THNSL2_uc002ssw.3_Intron|THNSL2_uc002ssx.3_Intron|THNSL2_uc002sta.3_Intron|THNSL2_uc002ssy.3_Missense_Mutation_p.D371Y|THNSL2_uc010fhe.2_Intron	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	371					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						GTCAGTGTCGGATGAAGCCAT	0.567			NA											15	36					2.48551e-13	3.38029e-13	0.0333	1	0
XIRP2	129446	broad.mit.edu	37	2	168100016	168100016	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:168100016G>T	uc002udx.2	+	8	2132	c.2114G>T	c.(2113-2115)GGA>GTA	p.G705V	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G530V|XIRP2_uc010fpq.2_Missense_Mutation_p.G483V|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	530					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GATCAACTTGGACAGCTTCAT	0.383			NA											18	52					1.55795e-14	2.16205e-14	0.012319	1	0
XIRP2	129446	broad.mit.edu	37	2	168107682	168107683	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:168107682_168107683GG>TT	uc002udx.2	+	8	9798_9799	c.9780_9781GG>TT	c.(9778-9783)GAGGAA>GATTAA	p.3260_3261EE>D*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.3085_3086EE>D*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.3038_3039EE>D*|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3085_3086					actin cytoskeleton organization	cell junction	actin binding	p.E3260G(1)		skin(7)|ovary(6)|pancreas(1)	14						ACGCTCAAGAGGAAATCAGGAA	0.421			NA											22	57					0	0	0.004672	0	0
EVX2	344191	broad.mit.edu	37	2	176947074	176947074	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:176947074C>T	uc010zeu.1	-	2	717	c.531G>A	c.(529-531)GCG>GCA	p.A177A		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	177						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		AGCCACCCAGCGCCGCGCTCC	0.721			NA											4	7					0	0	0.009096	0	0
EVX2	344191	broad.mit.edu	37	2	176948244	176948244	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:176948244G>T	uc010zeu.1	-	1	447	c.261C>A	c.(259-261)ACC>ACA	p.T87T		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	87						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CGGAGGAGACGGTGCTTTCGC	0.627			NA											13	41					6.72482e-11	8.794e-11	0.024245	1	0
TTN	7273	broad.mit.edu	37	2	179545040	179545040	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:179545040C>A	uc010zfg.1	-	136	29851	c.29627G>T	c.(29626-29628)AGG>ATG	p.R9876M	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R6537M|TTN_uc010fre.1_Intron|TTN_uc002una.1_5'Flank|TTN_uc010frf.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10803							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCGACAACCCTCTTGGGCTT	0.403			NA											44	144					5.78141e-17	8.19034e-17	0.045515	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801843	185801843	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:185801843G>T	uc002uph.2	+	4	2314	c.1720G>T	c.(1720-1722)GAT>TAT	p.D574Y		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	574						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GGACACTCTAGATGAAAAATA	0.299			NA											15	45					3.41278e-10	4.3513e-10	0.0333	1	0
DNAH7	56171	broad.mit.edu	37	2	196689076	196689076	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:196689076C>A	uc002utj.3	-	49	9295	c.9194G>T	c.(9193-9195)CGG>CTG	p.R3065L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3065	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GTCCCCAAGCCGGATACATGT	0.413			NA											24	83					3.96558e-24	6.03716e-24	0.024334	1	0
SMARCAL1	50485	broad.mit.edu	37	2	217285103	217285103	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:217285103G>A	uc002vgc.3	+	5	1274	c.944G>A	c.(943-945)AGC>AAC	p.S315N	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.S315N|SMARCAL1_uc010fvg.2_Missense_Mutation_p.S315N	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	315					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCCTCCACCAGCAGTGAGGGA	0.577			NA							Schimke_Immuno-Osseous_Dysplasia				3	50					0	0	0.004672	0	0
PTPRN	5798	broad.mit.edu	37	2	220164773	220164773	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:220164773G>C	uc002vkz.2	-	9	1459	c.1370C>G	c.(1369-1371)ACG>AGG	p.T457R	PTPRN_uc010zlc.1_Missense_Mutation_p.T367R|PTPRN_uc002vla.2_Missense_Mutation_p.T457R	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	457	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCCTGCCACCGTGGGCTGGCT	0.602			NA											21	68					0	0	0.055883	0	0
COL4A4	1286	broad.mit.edu	37	2	227896701	227896701	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:227896701T>A	uc010zlt.1	-	40	4431	c.3777A>T	c.(3775-3777)CCA>CCT	p.P1259P		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1259	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GATCTCCAGGTGGACCCGGGT	0.537			NA											9	25					0	0	0.047766	0	0
ANKMY1	51281	broad.mit.edu	37	2	241420440	241420440	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:241420440T>C	uc002vyz.1	-	16	2922	c.2693A>G	c.(2692-2694)TAC>TGC	p.Y898C	ANKMY1_uc002vza.1_Missense_Mutation_p.Y674C|ANKMY1_uc010fzd.1_Missense_Mutation_p.Y987C|ANKMY1_uc002vzb.1_Missense_Mutation_p.Y659C|ANKMY1_uc002vzc.1_Missense_Mutation_p.Y677C|ANKMY1_uc002vzd.1_Missense_Mutation_p.Y721C	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	898	MYND-type.						zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CAGGATCCCGTAGCAGCGAGG	0.617			NA											16	63					0	0	0.038395	0	0
C20orf71	128861	broad.mit.edu	37	20	31811753	31811753	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr20:31811753G>A	uc002wyr.2	+	2	472	c.264G>A	c.(262-264)CAG>CAA	p.Q88Q	C20orf71_uc002wys.2_Silent_p.Q88Q	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	88	Poly-Gln.					extracellular region	lipid binding			ovary(1)|skin(1)	2						AACACCAGCAGCAGCAAGAGA	0.572			NA											4	68					0	0	0.009096	0	0
KCNQ2	3785	broad.mit.edu	37	20	62071028	62071028	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr20:62071028A>C	uc002yey.1	-	6	1027	c.850T>G	c.(850-852)TAC>GAC	p.Y284D	KCNQ2_uc002yez.1_Missense_Mutation_p.Y284D|KCNQ2_uc002yfa.1_Missense_Mutation_p.Y284D|KCNQ2_uc002yfb.1_Missense_Mutation_p.Y284D|KCNQ2_uc011aax.1_Missense_Mutation_p.Y284D|KCNQ2_uc002yfc.1_Missense_Mutation_p.Y284D	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	284					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GTCTGGGGGTACTTGTCCCCG	0.642			NA											14	61					0	0	0.024245	0	0
MORC3	23515	broad.mit.edu	37	21	37741631	37741631	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr21:37741631T>A	uc002yvi.2	+	15	2041	c.1965T>A	c.(1963-1965)GTT>GTA	p.V655V		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	655					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						AAGAAACTGTTGAAGACGAGA	0.438			NA											24	73					0	0	0.014323	0	0
COL18A1	80781	broad.mit.edu	37	21	46896293	46896293	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr21:46896293C>T	uc011afs.1	+	5	2093	c.2072C>T	c.(2071-2073)GCG>GTG	p.A691V	COL18A1_uc002zhg.2_Missense_Mutation_p.A276V|COL18A1_uc002zhi.2_Missense_Mutation_p.A456V	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	691	Nonhelical region 1 (NC1).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGGCTCCCCGCGCCACCCCCC	0.637			NA											9	27					0	0	0.047766	0	0
MICAL3	57553	broad.mit.edu	37	22	18300821	18300822	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr22:18300821_18300822CC>AA	uc002zng.3	-	26	4958_4959	c.4605_4606GG>TT	c.(4603-4608)GAGGAC>GATTAC	p.1535_1536ED>DY	MICAL3_uc011agl.1_Missense_Mutation_p.1451_1452ED>DY|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1535_1536						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		AGGCTTGAGTCCTCAGTCTTGT	0.629			NA											8	22					0	0	0.004672	0	0
PPARA	5465	broad.mit.edu	37	22	46627756	46627756	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr22:46627756C>T	uc003bgw.1	+	8	1045	c.779C>T	c.(778-780)GCC>GTC	p.A260V	PPARA_uc003bgx.1_Missense_Mutation_p.A260V|PPARA_uc010hab.1_Missense_Mutation_p.A260V|PPARA_uc003bhb.1_Missense_Mutation_p.A260V|PPARA_uc010hac.1_Missense_Mutation_p.A57V	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	260					fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	AAGCTGGTGGCCAATGGCATC	0.552			NA											8	27					0	0	0.038147	0	0
STAB1	23166	broad.mit.edu	37	3	52544224	52544224	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:52544224C>A	uc003dej.2	+	24	2675	c.2601C>A	c.(2599-2601)CAC>CAA	p.H867Q		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	867	Extracellular (Potential).|EGF-like 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCTGCTCCCACCCGGACCGTG	0.622			NA											18	79					0.006122	0.00637188	0.038395	1	0
PBRM1	55193	broad.mit.edu	37	3	52584762	52584762	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:52584762C>A	uc003des.2	-	28	4692	c.4680_splice	c.e28+1	p.Q1560_splice	PBRM1_uc003dex.2_Splice_Site|PBRM1_uc003deq.2_Splice_Site_p.Q1453_splice|PBRM1_uc003der.2_Splice_Site_p.Q1473_splice|PBRM1_uc003det.2_Splice_Site_p.Q1468_splice|PBRM1_uc003deu.2_Splice_Site_p.Q1523_splice|PBRM1_uc003dev.2_Splice_Site|PBRM1_uc003dew.2_Splice_Site_p.Q1505_splice|PBRM1_uc010hmk.1_Splice_Site_p.Q1480_splice|PBRM1_uc003dey.2_Splice_Site_p.Q1453_splice	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGGAGGCTCACCTGTTGTCCA	0.478			NA	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								19	23					2.94398e-08	3.63983e-08	0.043863	1	0
SYNPR	132204	broad.mit.edu	37	3	63429126	63429126	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:63429126G>T	uc003dlq.2	+	1	374	c.5G>T	c.(4-6)TGT>TTT	p.C2F	SYNPR_uc003dlp.2_Intron|SYNPR_uc011bfk.1_Intron|SYNPR_uc011bfl.1_Intron|SYNPR_uc010hnt.2_5'UTR|SYNPR_uc011bfm.1_RNA	NM_144642	NP_653243	Q8TBG9	SYNPR_HUMAN	synaptoporin isoform 2	2	Cytoplasmic (Potential).|MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		TTGTAAATGTGTATGGTGATA	0.403	NSCLC(29;1052 1116 20025 32519)		NA											6	11					2.0095e-06	2.3425e-06	0.02938	1	0
PSMD6	9861	broad.mit.edu	37	3	64004295	64004295	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:64004295G>A	uc003dma.1	-	5	831	c.806C>T	c.(805-807)TCT>TTT	p.S269F	PSMD6_uc003dlz.1_Missense_Mutation_p.S220F|PSMD6_uc003dmb.1_Missense_Mutation_p.S322F|PSMD6_uc003dmc.1_Missense_Mutation_p.S230F|PSMD6_uc003dmd.1_Missense_Mutation_p.S231F	NM_014814	NP_055629	Q15008	PSMD6_HUMAN	proteasome (prosome, macropain) 26S subunit,	269	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	ATPase activity|protein binding			central_nervous_system(1)|skin(1)	2		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000805)|Kidney(15;0.00188)|KIRC - Kidney renal clear cell carcinoma(15;0.00212)		GAAGAAAACAGAGTAACGGCA	0.373			NA											12	25					0	0	0.016723	0	0
ABI3BP	25890	broad.mit.edu	37	3	100567717	100567717	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:100567717G>T	uc003dun.2	-	16	1463	c.1378C>A	c.(1378-1380)CCC>ACC	p.P460T	ABI3BP_uc003duo.2_Missense_Mutation_p.P502T|ABI3BP_uc011bhd.1_5'Flank|ABI3BP_uc003dum.2_5'Flank	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	460	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GTTTGCTGGGGAGCTGAAAGA	0.348			NA											12	46					3.07112e-06	3.53959e-06	0.010729	1	0
POLQ	10721	broad.mit.edu	37	3	121208648	121208648	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:121208648G>A	uc003eee.3	-	16	3259	c.3130C>T	c.(3130-3132)CGT>TGT	p.R1044C	POLQ_uc003eed.2_Missense_Mutation_p.R216C	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1044					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGCTTTCTACGTTTCCAAGAT	0.398	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					5	123					0	0	0.014758	0	0
ATP13A4	84239	broad.mit.edu	37	3	193210752	193210752	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:193210752G>T	uc003ftd.2	-	5	595	c.487C>A	c.(487-489)CAT>AAT	p.H163N	ATP13A4_uc003fte.1_Missense_Mutation_p.H163N|ATP13A4_uc011bsr.1_5'UTR	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	163	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AATTTTTGATGTATCTTGGCA	0.308			NA											7	38					8.12818e-05	9.01168e-05	0.02938	1	0
UGT2B4	7363	broad.mit.edu	37	4	70351130	70351130	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr4:70351130C>A	uc003hek.3	-	5	1153	c.1106G>T	c.(1105-1107)AGA>ATA	p.R369I	UGT2B4_uc011cap.1_Missense_Mutation_p.R233I|UGT2B4_uc003hel.3_Intron	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	369					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TATAAAAGCTCTGGTTTTTGG	0.398			NA											50	155					2.55665e-31	4.10674e-31	0.048971	1	0
HNRNPD	3184	broad.mit.edu	37	4	83279893	83279893	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr4:83279893C>A	uc003hmm.1	-	4	858	c.540G>T	c.(538-540)CCG>CCT	p.P180P	HNRNPD_uc003hml.1_RNA|HNRNPD_uc003hmn.1_Silent_p.P161P|HNRNPD_uc003hmo.1_Silent_p.P180P|HNRNPD_uc003hmp.1_Silent_p.P161P|HNRNPD_uc010ijr.1_Silent_p.P161P|HNRNPD_uc011cci.1_Silent_p.P26P	NM_031370	NP_112738	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D	180					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding				0						TTTTTTTAACCGGCTCTTTTG	0.363			NA											26	57					9.90768e-06	1.12914e-05	0.024334	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33624444	33624444	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:33624444C>T	uc003jia.1	-	14	2198	c.2035G>A	c.(2035-2037)GAC>AAC	p.D679N	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	679	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ATCTCATAGTCACAGCCAACC	0.542			NA								HNSCC(64;0.19)			29	36					0	0	0.030593	0	0
SLC45A2	51151	broad.mit.edu	37	5	33951714	33951714	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:33951714G>T	uc003jid.2	-	5	1193	c.1101C>A	c.(1099-1101)GTC>GTA	p.V367V	SLC45A2_uc003jie.2_Silent_p.V367V|SLC45A2_uc003jif.3_3'UTR|SLC45A2_uc011coe.1_3'UTR	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	367	Helical; Name=8; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						ATCCAACCTCGACTCCTCTTT	0.453	Ovarian(31;380 859 8490 22203 49048)		NA											63	111					3.00063e-23	4.53428e-23	0.048971	1	0
NNT	23530	broad.mit.edu	37	5	43616166	43616166	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:43616166G>T	uc003joe.2	+	4	853	c.598G>T	c.(598-600)GGT>TGT	p.G200C	NNT_uc003jof.2_Missense_Mutation_p.G200C	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	200	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	CAACATTGCGGGGTAGGTTCT	0.413			NA											27	72					4.87955e-14	6.72587e-14	0.027356	1	0
IL31RA	133396	broad.mit.edu	37	5	55164699	55164699	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:55164699G>A	uc003jql.2	+	3	300	c.235G>A	c.(235-237)GAA>AAA	p.E79K	IL31RA_uc003jqk.2_Missense_Mutation_p.E79K|IL31RA_uc011cqj.1_Intron|IL31RA_uc003jqm.2_Missense_Mutation_p.E47K|IL31RA_uc003jqn.2_Missense_Mutation_p.E79K|IL31RA_uc010iwa.1_Missense_Mutation_p.E47K|IL31RA_uc003jqo.2_5'UTR	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	47	Extracellular (Potential).|Fibronectin type-III 1.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TCCAGGAAAGGAAACCAGTTA	0.418			NA											41	124					0	0	0.027894	0	0
H2AFY	9555	broad.mit.edu	37	5	134679002	134679002	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:134679002C>A	uc003lam.1	-	8	1111	c.901G>T	c.(901-903)GCT>TCT	p.A301S	uc003laj.1_RNA|H2AFY_uc003lal.1_RNA|H2AFY_uc003lao.1_Missense_Mutation_p.A300S|H2AFY_uc003lan.1_Missense_Mutation_p.A298S|H2AFY_uc003lap.1_RNA|H2AFY_uc003laq.1_RNA|H2AFY_uc003lar.1_RNA|H2AFY_uc011cxz.1_Missense_Mutation_p.A129S|H2AFY_uc003las.1_Missense_Mutation_p.A301S|H2AFY_uc003lat.1_Missense_Mutation_p.A300S	NM_138610	NP_613258	O75367	H2AY_HUMAN	H2A histone family, member Y isoform 3	301	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTATCATCAGCCAGGGCCAAG	0.498			NA											70	89					5.45122e-27	8.62054e-27	0.048971	1	0
PCDHA10	56139	broad.mit.edu	37	5	140236822	140236822	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:140236822G>T	uc003lhx.2	+	1	1189	c.1189G>T	c.(1189-1191)GTG>TTG	p.V397L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.V397L|PCDHA10_uc011dad.1_Missense_Mutation_p.V397L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	397	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCAAGCTGGTGTCCACCTA	0.592			NA											50	212					4.02871e-13	5.44276e-13	0.048971	1	0
PCDHB14	56122	broad.mit.edu	37	5	140604499	140604499	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:140604499C>G	uc003ljb.2	+	1	1422	c.1422C>G	c.(1420-1422)AGC>AGG	p.S474R	PCDHB14_uc011dal.1_Missense_Mutation_p.S321R	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	474	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGCGTCAGCGCCACAGACA	0.637	Ovarian(141;50 1831 27899 33809 37648)		NA											99	194					0	0	0.048971	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140746158	140746158	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:140746158C>A	uc003lju.1	+	1	2261	c.2261C>A	c.(2260-2262)TCC>TAC	p.S754Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.S754Y	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	754	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S754A(1)		ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGACCTATTCCCACGAGGTC	0.597			NA											50	187					5.57489e-27	8.74829e-27	0.048971	1	0
PDGFRB	5159	broad.mit.edu	37	5	149515374	149515374	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:149515374T>A	uc003lro.2	-	3	577	c.108A>T	c.(106-108)ACA>ACT	p.T36T	PDGFRB_uc010jhd.2_5'UTR|PDGFRB_uc011dcg.1_Silent_p.T36T	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	36	Extracellular (Potential).|Ig-like C2-type 1.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GCCCCGGGGGTGTGACGACCA	0.592			NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								12	39					0	0	0.028581	0	0
FAT2	2196	broad.mit.edu	37	5	150947209	150947209	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:150947209G>A	uc003lue.3	-	1	1297	c.1284C>T	c.(1282-1284)CAC>CAT	p.H428H	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.H428H	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	428	Extracellular (Potential).|Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTAGCTGATAGTGGGCTCTGT	0.498			NA											39	124					0	0	0.021022	0	0
NMUR2	56923	broad.mit.edu	37	5	151777686	151777686	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:151777686A>G	uc003luv.2	-	2	912	c.746T>C	c.(745-747)CTT>CCT	p.L249P		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	249	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			ATCTGCCTCAAGAGATTTGTC	0.358			NA											27	54					0	0	0.024334	0	0
ATP10B	23120	broad.mit.edu	37	5	160049472	160049472	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:160049472C>A	uc003lym.1	-	14	2588	c.1741G>T	c.(1741-1743)GCT>TCT	p.A581S	ATP10B_uc010jit.1_5'Flank|ATP10B_uc003lyn.2_Missense_Mutation_p.A139S	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	581	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAGAAATCAGCAATGGAGGAG	0.557			NA											30	25					3.99451e-17	5.69846e-17	0.041601	1	0
BTNL2	56244	broad.mit.edu	37	6	32374895	32374895	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:32374895C>T	uc003obg.1	-	1	6	c.6G>A	c.(4-6)GTG>GTA	p.V2V	BTNL2_uc010jty.1_5'UTR|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Silent_p.V2V	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	2	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						CTGGAAAATCCACCATCCTCC	0.507			NA											27	58					0	0	0.027356	0	0
MAPK13	5603	broad.mit.edu	37	6	36104692	36104692	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:36104692T>C	uc003ols.2	+	8	745	c.647T>C	c.(646-648)ATG>ACG	p.M216T	MAPK13_uc003olt.2_Intron	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	216	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						ATGGCAGAGATGCTGACAGGG	0.507			NA											22	60					0	0	0.014323	0	0
CRISP3	10321	broad.mit.edu	37	6	49704130	49704130	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:49704130G>T	uc003ozs.2	-	3	178	c.163C>A	c.(163-165)CCC>ACC	p.P55T		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	55					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTGGCAGGGGGAGATACTGCT	0.468			NA											50	117					2.81731e-22	4.19511e-22	0.048971	1	0
GLI3	2737	broad.mit.edu	37	7	42063167	42063167	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:42063167T>C	uc011kbh.1	-	10	1488	c.1397A>G	c.(1396-1398)GAC>GGC	p.D466G	GLI3_uc011kbg.1_Missense_Mutation_p.D407G	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	466					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TTCATCTTTGTCCCCTTCCTC	0.542			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				15	68					0	0	0.020292	0	0
GRB10	2887	broad.mit.edu	37	7	50694650	50694650	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:50694650C>T	uc003tpi.2	-	5	561	c.530G>A	c.(529-531)GGG>GAG	p.G177E	GRB10_uc003tph.3_Missense_Mutation_p.G119E|GRB10_uc003tpj.2_Missense_Mutation_p.G177E|GRB10_uc003tpk.2_Missense_Mutation_p.G177E|GRB10_uc010kzb.2_Missense_Mutation_p.G119E|GRB10_uc003tpl.2_Missense_Mutation_p.G171E|GRB10_uc003tpm.2_Missense_Mutation_p.G119E|GRB10_uc003tpn.2_Missense_Mutation_p.G119E	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	177	Ras-associating.				insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					TTTGCTTGTCCCATCTTCACT	0.413			NA							Russell-Silver_syndrome				60	181					0	0	0.048971	0	0
SEMA3D	223117	broad.mit.edu	37	7	84629152	84629152	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:84629152C>A	uc003uic.2	-	17	1978	c.1938G>T	c.(1936-1938)ACG>ACT	p.T646T	SEMA3D_uc010led.2_Silent_p.T646T|SEMA3D_uc003uib.2_Silent_p.T285T	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	646	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity	p.T646M(1)		ovary(3)|large_intestine(2)	5						GCCCATATTCCGTTTTGATGA	0.408	Ovarian(63;442 1191 17318 29975 31528)		NA											11	23					0.000978159	0.00103929	0.010729	1	0
COL1A2	1278	broad.mit.edu	37	7	94053727	94053727	+	Missense_Mutation	SNP	G	G	A	rs140368271		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:94053727G>A	uc003ung.1	+	41	3116	c.2645G>A	c.(2644-2646)CGT>CAT	p.R882H	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_RNA	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	882					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AGAGGTGAACGTGGTCTACCA	0.478			NA								HNSCC(75;0.22)			29	89					0	0	0.037714	0	0
ARPC1B	10095	broad.mit.edu	37	7	98987630	98987630	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:98987630G>C	uc003upz.2	+	5	584	c.495G>C	c.(493-495)AAG>AAC	p.K165N	ARPC1B_uc003uqa.2_Missense_Mutation_p.K165N|ARPC1B_uc003uqb.2_Missense_Mutation_p.K165N|ARPC1B_uc003uqc.2_Missense_Mutation_p.K165N|ARPC1B_uc003uqd.2_5'Flank	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	165	WD 4.				cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GTGACTTCAAGTGTCGGTGAG	0.622			NA											37	80					0	0	0.015359	0	0
LRRC17	10234	broad.mit.edu	37	7	102574765	102574765	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:102574765A>T	uc003vau.2	+	2	794	c.405A>T	c.(403-405)TTA>TTT	p.L135F	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.L135F	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	135	LRR 3.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						CCACCCTCTTACTGCAGCACA	0.443			NA											16	49					0	0	0.028581	0	0
CCDC136	64753	broad.mit.edu	37	7	128441511	128441511	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:128441511G>T	uc003vnv.1	+	4	985	c.618G>T	c.(616-618)AAG>AAT	p.K206N	CCDC136_uc003vnu.1_Missense_Mutation_p.K256N|CCDC136_uc003vnw.1_Missense_Mutation_p.K206N|CCDC136_uc003vnx.1_Missense_Mutation_p.K22N|CCDC136_uc010llq.1_5'UTR	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	206	Glu-rich.					integral to membrane	protein binding			ovary(2)	2						TGGAAATGAAGAGCTCTGAAC	0.483			NA											4	20					0.000602214	0.000646588	0.014758	1	0
FLNC	2318	broad.mit.edu	37	7	128484144	128484144	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:128484144C>A	uc003vnz.3	+	20	3225	c.3016C>A	c.(3016-3018)CCC>ACC	p.P1006T	FLNC_uc003voa.3_Missense_Mutation_p.P1006T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1006	Filamin 8.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GATGACTTCGCCCTCTCGCCG	0.662			NA											15	30					4.7546e-09	5.91426e-09	0.028581	1	0
CLCN1	1180	broad.mit.edu	37	7	143043333	143043333	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:143043333C>A	uc003wcr.1	+	18	2360	c.2273C>A	c.(2272-2274)CCA>CAA	p.P758Q	CLCN1_uc011ktc.1_Missense_Mutation_p.P370Q	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	758	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CCGGAAGCACCAGAGCCTGCA	0.592			NA											13	40					0.00010058	0.000110313	0.013537	1	0
MLL3	58508	broad.mit.edu	37	7	151874411	151874411	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:151874411G>A	uc003wla.2	-	38	8346	c.8127C>T	c.(8125-8127)GTC>GTT	p.V2709V	MLL3_uc003wkz.2_Silent_p.V1770V|MLL3_uc003wky.2_Silent_p.V218V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2709	Asp-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTAAGTCTTTGACTTCAACCC	0.378	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								23	72					0	0	0.014323	0	0
MLL3	58508	broad.mit.edu	37	7	151945239	151945239	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:151945239T>C	uc003wla.2	-	14	2499	c.2280A>G	c.(2278-2280)ATA>ATG	p.I760M		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	760					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATGATAACTTTATAGATTTGC	0.408	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								5	191					0	0	0.016723	0	0
ABRA	137735	broad.mit.edu	37	8	107773518	107773518	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr8:107773518C>G	uc003ymm.3	-	2	947	c.893G>C	c.(892-894)AGG>ACG	p.R298T		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	298					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			ACGCTTGGCCCTTTCAGCAGT	0.517			NA											16	43					0	0	0.028581	0	0
ASAP1	50807	broad.mit.edu	37	8	131193098	131193098	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr8:131193098G>A	uc003yta.1	-	7	587	c.559C>T	c.(559-561)CAC>TAC	p.H187Y	ASAP1_uc003ysz.1_5'UTR|ASAP1_uc011liw.1_Missense_Mutation_p.H180Y	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	187					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TGTTTTGCGTGCTCTCTTTTC	0.333			NA											5	135					0	0	0.014758	0	0
OC90	729330	broad.mit.edu	37	8	133048637	133048637	+	Silent	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr8:133048637C>G	uc003ytg.2	-	8	660	c.660G>C	c.(658-660)CTG>CTC	p.L220L	OC90_uc011lix.1_Intron	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	236					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			AGAGAGTGATCAGTCTGTCAG	0.433			NA											18	54					0	0	0.055883	0	0
PTPRD	5789	broad.mit.edu	37	9	8484343	8484343	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:8484343C>A	uc003zkk.2	-	29	3900	c.3189G>T	c.(3187-3189)GTG>GTT	p.V1063V	PTPRD_uc003zkp.2_Silent_p.V652V|PTPRD_uc003zkq.2_Silent_p.V652V|PTPRD_uc003zkr.2_Silent_p.V647V|PTPRD_uc003zks.2_Silent_p.V642V|PTPRD_uc003zkl.2_Silent_p.V1054V|PTPRD_uc003zkm.2_Silent_p.V1050V|PTPRD_uc003zkn.2_Silent_p.V652V|PTPRD_uc003zko.2_Silent_p.V649V	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1063	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTCGGCCATCCACTTCTTCTA	0.378			NA								TSP Lung(15;0.13)			11	29					3.86212e-05	4.32897e-05	0.008291	1	0
IFNA8	3445	broad.mit.edu	37	9	21409660	21409660	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:21409660G>A	uc003zpc.1	+	1	515	c.485G>A	c.(484-486)TGT>TAT	p.C162Y		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	162					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		TACAGCTCTTGTGCCTGGGAG	0.428			NA											76	232					0	0	0.048971	0	0
TOPORS	10210	broad.mit.edu	37	9	32541434	32541434	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:32541434C>A	uc003zrb.2	-	3	3256	c.3089G>T	c.(3088-3090)CGG>CTG	p.R1030L	TOPORS_uc003zrc.2_Missense_Mutation_p.R963L	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	1030					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TAATGATGTCCGTGGCGATGG	0.393			NA											21	56					1.01871e-10	1.30703e-10	0.049695	1	0
FRMPD1	22844	broad.mit.edu	37	9	37745408	37745408	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:37745408G>T	uc004aag.1	+	16	3423	c.3379G>T	c.(3379-3381)GAG>TAG	p.E1127*	FRMPD1_uc004aah.1_Nonsense_Mutation_p.E1127*	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1127						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CGTATTTCAGGAGGAGTCTAG	0.428			NA											14	53					1.3612e-06	1.61445e-06	0.024245	1	0
PRUNE2	158471	broad.mit.edu	37	9	79325166	79325166	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:79325166T>C	uc010mpk.2	-	8	2148	c.2024A>G	c.(2023-2025)GAA>GGA	p.E675G		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	675					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AGATTCCTGTTCACTGGAACT	0.498			NA											15	42					0	0	0.020292	0	0
FLJ43950	347127	broad.mit.edu	37	9	84530312	84530312	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:84530312G>A	uc011lst.1	+	4	334	c.233G>A	c.(232-234)GGA>GAA	p.G78E		NR_026851				SubName: Full=cDNA FLJ43950 fis, clone TESTI4015293, moderately similar to FAM75-like protein;												0						TGCAGCTTTGGACCTCCTGCT	0.577			NA											4	11					0	0	0.014758	0	0
OR13F1	138805	broad.mit.edu	37	9	107267390	107267390	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:107267390C>A	uc011lvm.1	+	1	847	c.847C>A	c.(847-849)CCC>ACC	p.P283T		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						CGGACAAACCCCCATGTTGAA	0.418			NA											24	49					9.57634e-11	1.24431e-10	0.01892	1	0
ASTN2	23245	broad.mit.edu	37	9	119976989	119976989	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:119976989C>A	uc004bjs.1	-	3	764	c.663G>T	c.(661-663)CTG>CTT	p.L221L	ASTN2_uc004bjr.1_Silent_p.L221L|ASTN2_uc004bjt.1_Silent_p.L221L	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	221	Helical; (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGGTGAACACCAGCAGCAGCA	0.597			NA											16	31					6.94344e-10	8.7436e-10	0.038395	1	0
SFRS17A	8227	broad.mit.edu	37	X	1714286	1714286	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:1714286G>T	uc004cqa.2	+	3	968	c.772G>T	c.(772-774)GAT>TAT	p.D258Y	SFRS17A_uc010ncx.1_Missense_Mutation_p.D258Y|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_5'Flank	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	258					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTTTCTTTTGATTCGACCAA	0.537			NA											61	87					1.40369e-38	2.29082e-38	0.048971	1	0
HDHD1A	8226	broad.mit.edu	37	X	6995490	6995490	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:6995490C>A	uc004crv.2	-	3	358	c.281G>T	c.(280-282)GGG>GTG	p.G94V	HDHD1A_uc011mhm.1_Missense_Mutation_p.G117V|HDHD1A_uc011mhn.1_Missense_Mutation_p.G51V|HDHD1A_uc010ndl.2_Intron|HDHD1A_uc011mho.1_Missense_Mutation_p.G94V	NM_012080	NP_036212	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain	94					nucleotide metabolic process		metal ion binding|phosphatase activity				0		Colorectal(8;0.0114)|Medulloblastoma(8;0.184)				TTTCTCCGCCCCTGGGGAGGA	0.612			NA											8	7					7.48243e-07	8.92641e-07	0.006214	1	0
SRPX	8406	broad.mit.edu	37	X	38024106	38024106	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:38024106C>A	uc004ddy.1	-	5	655	c.569G>T	c.(568-570)CGC>CTC	p.R190L	SRPX_uc004ddz.1_Missense_Mutation_p.R170L|SRPX_uc011mkh.1_Missense_Mutation_p.R131L|SRPX_uc011mki.1_Missense_Mutation_p.R190L	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	190	HYR.				cell adhesion	cell surface|membrane					0						TTCTGCAATGCGTTCCTTCAC	0.443			NA											11	10					3.07112e-06	3.53959e-06	0.010729	1	0
RBM10	8241	broad.mit.edu	37	X	47044523	47044523	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:47044523C>T	uc004dhf.2	+	18	2399	c.2020C>T	c.(2020-2022)CAG>TAG	p.Q674*	RBM10_uc004dhg.2_Nonsense_Mutation_p.Q596*|RBM10_uc004dhh.2_Nonsense_Mutation_p.Q673*|RBM10_uc010nhq.2_Nonsense_Mutation_p.Q597*|RBM10_uc004dhi.2_Nonsense_Mutation_p.Q739*	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	674					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						AAATAGCTTCCAGCCTATCAG	0.567	Melanoma(171;120 2705 19495 39241)		NA											19	14					0	0	0.043863	0	0
TEX11	56159	broad.mit.edu	37	X	70127661	70127661	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:70127661C>A	uc004dyl.2	-	2	65	c.-97_splice	c.e2-1		TEX11_uc004dym.2_Splice_Site	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1								protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TGGCTCAAGCCTGTGAAATAA	0.338			NA											13	13					0.00010058	0.000110313	0.013537	1	0
RLIM	51132	broad.mit.edu	37	X	73812447	73812447	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:73812447T>C	uc004ebu.2	-	5	993	c.703A>G	c.(703-705)ATG>GTG	p.M235V	RLIM_uc004ebw.2_Missense_Mutation_p.M235V	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	235					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						ATTTCACTCATTGGATGCAGA	0.498	Esophageal Squamous(169;1899 1923 14997 18818 32118)		NA											36	17					0	0	0.017118	0	0
POF1B	79983	broad.mit.edu	37	X	84585975	84585975	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:84585975A>T	uc004eer.2	-	7	980	c.834T>A	c.(832-834)CAT>CAA	p.H278Q	POF1B_uc004ees.2_Missense_Mutation_p.H278Q	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	278							actin binding				0						TTCTCTGCAAATGTTCTAATA	0.368			NA											15	11					0	0	0.024245	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873486	91873486	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:91873486C>T	uc004efk.1	+	7	4436	c.3591C>T	c.(3589-3591)CAC>CAT	p.H1197H	PCDH11X_uc004efl.1_Silent_p.H1187H|PCDH11X_uc004efo.1_Silent_p.H1160H|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Silent_p.H1189H|PCDH11X_uc004efn.1_Silent_p.H1179H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1197	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTCTCTGCCACAGCCCTCCAG	0.597	NSCLC(38;925 1092 2571 38200 45895)		NA											8	87					0	0	0.038147	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795254	142795254	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:142795254C>A	uc004fbz.2	-	2	1178	c.424G>T	c.(424-426)GAC>TAC	p.D142Y		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	142										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGATGAGTCCAGGTCTTCG	0.512			NA											87	93					3.74932e-68	6.16824e-68	0.048971	1	0
SPANXN2	494119	broad.mit.edu	37	X	142795332	142795332	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:142795332C>A	uc004fbz.2	-	2	1100	c.346G>T	c.(346-348)GAC>TAC	p.D116Y		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	116										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGATGAGTCCAGGTCTTCG	0.517			NA											10	181					1.55795e-14	2.16205e-14	0.012319	1	0
PASD1	139135	broad.mit.edu	37	X	150832592	150832592	+	Silent	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:150832592C>G	uc004fev.3	+	11	1175	c.843C>G	c.(841-843)GCC>GCG	p.A281A		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	281						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCCTCAGCCTTATCCTTGC	0.468			NA											28	14					0	0	0.030593	0	0
GLS2	27165	broad.mit.edu	37	12	56868875	56868875	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:56868875delT	uc001slj.2	-	10	1228	c.949delA	c.(949-951)ACAfs	p.T317fs	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Frame_Shift_Del_p.T52fs|GLS2_uc009zot.2_Intron	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	317					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CGATCCCCTGTTTCCTTCTCT	0.473			NA											64	203	---	---	---	---	NA	NA	NA	NA	NA
ALOX12	239	broad.mit.edu	37	17	6913280	6913288	+	In_Frame_Del	DEL	CTGGTATGC	CTGGTATGC	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	CTGGTATGC	CTGGTATGC	-	-	CTGGTATGC	CTGGTATGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:6913280_6913288delCTGGTATGC	uc002gdx.3	+	13	1700_1708	c.1647_1655delCTGGTATGC	c.(1645-1656)GACTGGTATGCC>GAC	p.WYA550del	uc002gdy.1_Intron|ALOX12_uc002gdz.3_In_Frame_Del_p.WYA20del|RNASEK_uc002gea.2_5'Flank|C17orf49_uc002geb.3_5'Flank|C17orf49_uc002gec.2_5'Flank	NM_000697	NP_000688	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	550_552	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			central_nervous_system(1)	1						TCCAGCTGGACTGGTATGCCTGGGTCCCT	0.56			NA											10	75	---	---	---	---	NA	NA	NA	NA	NA
SERPINB11	89778	broad.mit.edu	37	18	61390583	61390584	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr18:61390583_61390584delCA	uc002ljk.3	+	9	1191_1192	c.1129_1130delCA	c.(1129-1131)CACfs	p.H377fs	SERPINB11_uc010xes.1_Frame_Shift_Del_p.H202fs|SERPINB11_uc010dqd.2_Intron|SERPINB11_uc002ljj.3_Frame_Shift_Del_p.H263fs|SERPINB11_uc010dqe.2_Frame_Shift_Del_p.H176fs|SERPINB11_uc010dqf.2_Frame_Shift_Del_p.H175fs	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	377					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				CTTTATAAGGCACACTCATACC	0.515	Ovarian(27;496 784 5942 8975 23930)		NA											31	87	---	---	---	---	NA	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179414066	179414066	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:179414066delT	uc010zfg.1	-	288	84807	c.84583delA	c.(84583-84585)AGCfs	p.S28195fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.S21890fs|TTN_uc010zfi.1_Frame_Shift_Del_p.S21823fs|TTN_uc010zfj.1_Frame_Shift_Del_p.S21698fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29122							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTTGTGCTTTTCTTTTCT	0.413			NA											29	82	---	---	---	---	NA	NA	NA	NA	NA
DRD3	1814	broad.mit.edu	37	3	113849986	113849986	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:113849986delG	uc003ebd.2	-	7	1408	c.985delC	c.(985-987)CAAfs	p.Q329fs	DRD3_uc010hqn.1_Frame_Shift_Del_p.Q329fs|DRD3_uc003ebb.1_Frame_Shift_Del_p.Q296fs|DRD3_uc003ebc.1_Frame_Shift_Del_p.Q329fs	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	329	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GCCACCATTTGGGTTGCCTTC	0.388			NA											17	54	---	---	---	---	NA	NA	NA	NA	NA
DRD3	1814	broad.mit.edu	37	3	113850028	113850028	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:113850028delG	uc003ebd.2	-	7	1366	c.943delC	c.(943-945)CTGfs	p.L315fs	DRD3_uc010hqn.1_Frame_Shift_Del_p.L315fs|DRD3_uc003ebb.1_Intron|DRD3_uc003ebc.1_Frame_Shift_Del_p.L315fs	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	315	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CGAGGTTGCAGGGGCCCCAGC	0.453			NA											31	104	---	---	---	---	NA	NA	NA	NA	NA
COL21A1	81578	broad.mit.edu	37	6	56044716	56044716	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:56044716delC	uc003pcs.2	-	3	532	c.300delG	c.(298-300)TTGfs	p.L100fs	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Frame_Shift_Del_p.L100fs|COL21A1_uc003pcu.1_Frame_Shift_Del_p.L100fs	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	100	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTGCTGCCGTCAAATGTTCTC	0.463			NA											12	27	---	---	---	---	NA	NA	NA	NA	NA
SFRP4	6424	broad.mit.edu	37	7	37956011	37956011	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:37956011delG	uc003tfo.3	-	1	515	c.129delC	c.(127-129)CCCfs	p.P43fs		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	43	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GCAGGTGGTTGGGCATCCGCG	0.682			NA											21	73	---	---	---	---	NA	NA	NA	NA	NA
