Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDK11B	984	broad.mit.edu	37	1	1573207	1573207	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:1573207C>A	uc001agv.1	-	17	1492	c.1381G>T	c.(1381-1383)GAG>TAG	p.E461*	CDK11B_uc009vkj.2_Nonsense_Mutation_p.E118*|CDK11B_uc001ags.1_Nonsense_Mutation_p.E319*|CDK11B_uc001agt.1_Nonsense_Mutation_p.E244*|CDK11B_uc001aha.1_Nonsense_Mutation_p.E427*|CDK11B_uc001agw.1_Nonsense_Mutation_p.E416*|CDK11B_uc001agy.1_Nonsense_Mutation_p.E459*|CDK11B_uc001agx.1_Nonsense_Mutation_p.E450*|CDK11B_uc001agz.1_Nonsense_Mutation_p.E205*	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	474	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CCCTCCTTCTCCTTCTCCATC	0.532			NA											36	56					9.45814e-24	1.88499e-23	0.004878	1	0
CCDC27	148870	broad.mit.edu	37	1	3669132	3669132	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:3669132C>A	uc001akv.2	+	1	168	c.87C>A	c.(85-87)TCC>TCA	p.S29S		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	29										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CATTCAGGTCCACATTCAGGC	0.567			NA											13	50					0.000308642	0.000399792	0.003163	1	0
DNAJC11	55735	broad.mit.edu	37	1	6705159	6705159	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:6705159T>C	uc001aof.2	-	9	1028	c.922A>G	c.(922-924)ATC>GTC	p.I308V	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Missense_Mutation_p.I308V|DNAJC11_uc010nzu.1_Missense_Mutation_p.I218V	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	308					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TGATAGCTGATCAGTGCAAAG	0.542			NA											14	168					0	0	0.006122	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12942103	12942103	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:12942103C>A	uc001aun.2	-	3	518	c.447G>T	c.(445-447)TTG>TTT	p.L149F		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	149										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGAACACAGTCAAGGGCTGCC	0.498			NA											38	137					5.13769e-22	1.01857e-21	0.00361	1	0
PADI6	353238	broad.mit.edu	37	1	17708498	17708498	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:17708498A>T	uc001bak.1	+	6	590	c.590A>T	c.(589-591)CAA>CTA	p.Q197L		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	189					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CTGAATGTCCAAGGCCCCAGC	0.498			NA											6	38					0	0	0.001168	0	0
TAS1R2	80834	broad.mit.edu	37	1	19180801	19180801	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:19180801A>T	uc001bba.1	-	3	1164	c.1163T>A	c.(1162-1164)GTG>GAG	p.V388E		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	388	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CGCAGAGTACACGCTGTAGAC	0.592			NA											3	23					0	0	0.004672	0	0
TMCO4	255104	broad.mit.edu	37	1	20009760	20009760	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:20009760C>A	uc001bcn.2	-	16	1920	c.1678G>T	c.(1678-1680)GGG>TGG	p.G560W	TMCO4_uc001bcm.2_Missense_Mutation_p.G391W|TMCO4_uc001bco.1_Intron|TMCO4_uc001bcp.1_Intron	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	560						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		TGGGTTTGCCCAACCTGGTGG	0.662			NA											15	63					1.37285e-15	2.65232e-15	0.004007	1	0
SRRM1	10250	broad.mit.edu	37	1	24977944	24977944	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:24977944T>A	uc001bjm.2	+	6	790	c.566T>A	c.(565-567)GTC>GAC	p.V189D	SRRM1_uc010oel.1_Missense_Mutation_p.V189D|SRRM1_uc009vrh.1_Missense_Mutation_p.V150D|SRRM1_uc009vri.1_Missense_Mutation_p.V106D|SRRM1_uc010oem.1_Intron	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	189	Arg-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TCTTCCCCTGTCAGGAGAGAG	0.463	Ovarian(68;897 1494 3282 17478)		NA											4	23					0	0	0.000602	0	0
FNDC5	252995	broad.mit.edu	37	1	33333801	33333801	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:33333801G>T	uc001bwg.2	-	3	389	c.174C>A	c.(172-174)TCC>TCA	p.S58S	FNDC5_uc001bwf.1_Silent_p.S58S	NM_153756	NP_715637	Q8NAU1	FNDC5_HUMAN	fibronectin type III domain containing 5	117	Extracellular (Potential).					integral to membrane|peroxisomal membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTTTGTTCTTGGAGGCCATCT	0.602			NA											11	105					5.50884e-06	8.26689e-06	0.001368	1	0
C1orf94	84970	broad.mit.edu	37	1	34663443	34663443	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:34663443A>C	uc001bxs.3	+	2	767	c.368A>C	c.(367-369)CAG>CCG	p.Q123P	C1orf94_uc001bxt.2_Missense_Mutation_p.Q313P	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	123							protein binding				0		Myeloproliferative disorder(586;0.0393)				CAGAAGAGGCAGCTCCCAGTG	0.612			NA											4	45					0	0	0.000602	0	0
TRAPPC3	27095	broad.mit.edu	37	1	36603508	36603508	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:36603508G>A	uc001bzx.2	-	4	400	c.312C>T	c.(310-312)TCC>TCT	p.S104S	TRAPPC3_uc001bzy.2_Silent_p.S58S	NM_014408	NP_055223	O43617	TPPC3_HUMAN	trafficking protein particle complex 3	104						endoplasmic reticulum	guanylate cyclase activity|heme binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0393)				CCAAAATGAGGGAGAATTCAT	0.478			NA											20	45					0	0	0.001523	0	0
OSCP1	127700	broad.mit.edu	37	1	36884607	36884607	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:36884607G>T	uc001cap.2	-	10	1120	c.1038C>A	c.(1036-1038)AAC>AAA	p.N346K	OSCP1_uc001caq.2_Missense_Mutation_p.N336K	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	346					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGGCTTGTATGTTGATAACTT	0.388			NA											22	130					1.64293e-13	3.1315e-13	0.00333	1	0
MACF1	23499	broad.mit.edu	37	1	39800883	39800883	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:39800883G>C	uc010oiu.1	+	1	4074	c.3943G>C	c.(3943-3945)GGT>CGT	p.G1315R	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2880					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TAATCTTAAAGGTAAATCCTT	0.343			NA											14	39					0	0	0.003163	0	0
MACF1	23499	broad.mit.edu	37	1	39853090	39853090	+	Missense_Mutation	SNP	C	C	G	rs151008241		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:39853090C>G	uc010oiu.1	+	22	10027	c.9896C>G	c.(9895-9897)TCT>TGT	p.S3299C	MACF1_uc010ois.1_Missense_Mutation_p.S2797C|MACF1_uc001cda.1_Missense_Mutation_p.S2684C|MACF1_uc001cdc.1_Missense_Mutation_p.S1863C	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4864	Spectrin 4.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGGGGAATCTCTACTTCTT	0.433			NA											10	149					0	0	0.006214	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046123	42046123	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:42046123C>A	uc001cgz.3	-	4	5559	c.4346G>T	c.(4345-4347)AGA>ATA	p.R1449I	HIVEP3_uc001cha.3_Missense_Mutation_p.R1449I|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1449	Potential.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTCCTTCACTCTTTTTTGCTG	0.527			NA											35	71					2.05212e-20	4.04723e-20	0.005524	1	0
SCP2	6342	broad.mit.edu	37	1	53480639	53480639	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:53480639G>T	uc001cur.1	+	12	1280	c.1159G>T	c.(1159-1161)GCT>TCT	p.A387S	SCP2_uc001cus.1_RNA|SCP2_uc010ono.1_Missense_Mutation_p.A306S|SCP2_uc010onp.1_Missense_Mutation_p.A363S|SCP2_uc009vzi.1_Missense_Mutation_p.A343S|SCP2_uc010onq.1_5'UTR|SCP2_uc001cut.1_5'UTR|SCP2_uc001cuu.1_5'UTR	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein	387					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1						TGCAAAGGTGGCTCTGCAGCA	0.512			NA											10	37					3.86212e-05	5.4165e-05	0.008291	1	0
LRP8	7804	broad.mit.edu	37	1	53755277	53755277	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:53755277T>A	uc001cvi.1	-	3	471	c.329A>T	c.(328-330)GAG>GTG	p.E110V	LRP8_uc001cvh.1_5'UTR|LRP8_uc001cvk.1_Missense_Mutation_p.E110V|LRP8_uc001cvj.1_Missense_Mutation_p.E110V|LRP8_uc001cvl.1_Missense_Mutation_p.E110V	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	110	LDL-receptor class A 2.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						ATCAGGACACTCCTCCTCGCC	0.597			NA											4	12					0	0	0.000248	0	0
C1orf175	374977	broad.mit.edu	37	1	55134563	55134563	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:55134563C>T	uc010ooe.1	+	5	1666	c.1342C>T	c.(1342-1344)CTG>TTG	p.L448L	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Silent_p.L16L|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_5'UTR|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Silent_p.L448L|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	448						integral to membrane	binding				0						GAGCCAGGATCTGCTGGAGGC	0.557			NA											11	47					0	0	0.000978	0	0
C1orf175	374977	broad.mit.edu	37	1	55166854	55166854	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:55166854G>T	uc010ooe.1	+	19	3468	c.3144G>T	c.(3142-3144)AAG>AAT	p.K1048N	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.K566N|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.K250N	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1048	HEAT 2.					integral to membrane	binding				0						CCATGGTGAAGGGCCTGAAGA	0.592			NA											6	33					3.59834e-05	5.08422e-05	0.001168	1	0
DAB1	1600	broad.mit.edu	37	1	57476878	57476878	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:57476878G>T	uc001cys.1	-	15	2186	c.1512C>A	c.(1510-1512)ACC>ACA	p.T504T	DAB1_uc001cyt.1_Silent_p.T502T|DAB1_uc001cyq.1_Silent_p.T502T|DAB1_uc001cyr.1_Silent_p.T418T|DAB1_uc009vzw.1_Silent_p.T486T|DAB1_uc009vzx.1_Silent_p.T504T	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	537					cell differentiation|nervous system development					skin(2)|ovary(1)	3						TGTCATCTGTGGTAGGATCAC	0.448			NA											7	89					8.12818e-05	0.000110582	0.001984	1	0
HOOK1	51361	broad.mit.edu	37	1	60312847	60312847	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:60312847G>C	uc009wad.2	+	11	1021	c.919G>C	c.(919-921)GAT>CAT	p.D307H	HOOK1_uc001czo.2_Missense_Mutation_p.D307H|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.D265H	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	307	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					AGATGAAATAGATGTTCTTAG	0.333			NA											14	85					0	0	0.00245	0	0
PDE4B	5142	broad.mit.edu	37	1	66723362	66723362	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:66723362C>T	uc001dcn.2	+	5	700	c.509C>T	c.(508-510)GCC>GTC	p.A170V	PDE4B_uc009war.2_Missense_Mutation_p.A78V|PDE4B_uc001dco.2_Missense_Mutation_p.A170V|PDE4B_uc001dcp.2_Missense_Mutation_p.A155V	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	170					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	ACTCCTTTTGCCCAGGTATGT	0.388			NA											11	159					0	0	0.001368	0	0
COL24A1	255631	broad.mit.edu	37	1	86591502	86591502	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:86591502G>A	uc001dlj.2	-	3	559	c.517C>T	c.(517-519)CAA>TAA	p.Q173*	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Nonsense_Mutation_p.Q173*	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	173	TSP N-terminal.|Laminin G-like.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GAGACACTTTGGTTTCTAATA	0.353			NA											6	33					0	0	0.001984	0	0
CLCA4	22802	broad.mit.edu	37	1	87041270	87041270	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:87041270G>C	uc009wcs.2	+	11	1983	c.1939G>C	c.(1939-1941)GAT>CAT	p.D647H	CLCA4_uc009wct.2_Missense_Mutation_p.D410H|CLCA4_uc009wcu.2_Missense_Mutation_p.D467H	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	647						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GGAACTTTTGGATAATGGTGC	0.393			NA											6	98					0	0	0.00308	0	0
BRDT	676	broad.mit.edu	37	1	92446675	92446675	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:92446675C>A	uc001dok.3	+	10	2039	c.1690C>A	c.(1690-1692)CTA>ATA	p.L564I	BRDT_uc001dol.3_Missense_Mutation_p.L564I|BRDT_uc010osz.1_Missense_Mutation_p.L568I|BRDT_uc009wdf.2_Missense_Mutation_p.L491I|BRDT_uc010ota.1_Missense_Mutation_p.L518I|BRDT_uc010otb.1_Missense_Mutation_p.L518I|BRDT_uc001dom.3_Missense_Mutation_p.L564I	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AGCATCAACACTAAGAGAATT	0.358			NA											3	62					0.004672	0.00544907	0.004672	1	0
DPYD	1806	broad.mit.edu	37	1	97981407	97981407	+	Missense_Mutation	SNP	C	C	G	rs142619737	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:97981407C>G	uc001drv.2	-	13	1752	c.1615G>C	c.(1615-1617)GGA>CGA	p.G539R		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	539					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AACTTCAATCCGGCCATTTCT	0.448			NA											8	29					0	0	0.004482	0	0
LPPR5	163404	broad.mit.edu	37	1	99418657	99418657	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:99418657G>T	uc001dsb.2	-	3	812	c.590C>A	c.(589-591)GCT>GAT	p.A197D	LPPR5_uc001dsc.2_Missense_Mutation_p.A197D	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	197	Helical; (Potential).					integral to membrane	hydrolase activity				0						GACACTGAGAGCTGCTTCTTT	0.393			NA											16	32					6.31663e-08	1.05836e-07	0.003163	1	0
LPPR4	9890	broad.mit.edu	37	1	99772549	99772549	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:99772549C>A	uc001dse.2	+	7	2381	c.2275C>A	c.(2275-2277)CGG>AGG	p.R759R	LPPR4_uc010oue.1_Silent_p.R701R	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	759							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CTCCCCCACACGGGCTTATAA	0.458			NA											18	43					8.00594e-06	1.19983e-05	0.007413	1	0
OLFM3	118427	broad.mit.edu	37	1	102290605	102290605	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:102290605A>T	uc001duf.2	-	4	700	c.629T>A	c.(628-630)CTT>CAT	p.L210H	OLFM3_uc001dug.2_Missense_Mutation_p.L190H|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.L115H|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	210	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GCAGTCACGAAGTCTTGTTTC	0.368			NA											4	35					0	0	0.000248	0	0
KCNA2	3737	broad.mit.edu	37	1	111145926	111145926	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:111145926G>C	uc001dzu.2	-	2	1975	c.1479C>G	c.(1477-1479)ACC>ACG	p.T493T	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Silent_p.T493T	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	493						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TTAACATTTTGGTAATATTCA	0.383	Pancreas(18;568 735 10587 23710 36357)		NA											13	72					0	0	0.001368	0	0
IGSF3	3321	broad.mit.edu	37	1	117127668	117127668	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:117127668C>A	uc001egr.1	-	9	3152	c.2447G>T	c.(2446-2448)CGC>CTC	p.R816L	IGSF3_uc001egq.1_Missense_Mutation_p.R836L|IGSF3_uc001egs.1_Missense_Mutation_p.R489L	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	816	Ig-like C2-type 7.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GAGCCTCAGGCGGCTGTCTGG	0.562			NA											4	38					1.23904e-05	1.80687e-05	0.000602	1	0
SPAG17	200162	broad.mit.edu	37	1	118574352	118574352	+	Missense_Mutation	SNP	A	A	G	rs144404732		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:118574352A>G	uc001ehk.2	-	25	3640	c.3572T>C	c.(3571-3573)CTT>CCT	p.L1191P		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1191						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTCTTCTTTAAGGGATTCTTT	0.378			NA											27	81					0	0	0.00632	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296373	145296373	+	Missense_Mutation	SNP	G	G	T	rs3969711		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:145296373G>T	uc001end.3	+	3	330	c.295G>T	c.(295-297)GTT>TTT	p.V99F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.V99F|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	99											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TAAAGTCCTAGTTCACTCTCA	0.473			NA											4	122					0.00116845	0.00142726	0.001168	1	0
ANKRD35	148741	broad.mit.edu	37	1	145562033	145562033	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:145562033C>A	uc001eob.1	+	10	1829	c.1721C>A	c.(1720-1722)GCC>GAC	p.A574D	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.A417D	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	574										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTAAAGGCAGCCCCAGGGAGC	0.602	Melanoma(9;127 754 22988 51047)		NA											11	59					5.16669e-11	9.4667e-11	0.000978	1	0
PIAS3	10401	broad.mit.edu	37	1	145578347	145578347	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:145578347G>T	uc001eoc.1	+	2	401	c.310G>T	c.(310-312)GGC>TGC	p.G104C	NBPF10_uc001emp.3_Intron|PIAS3_uc010oyy.1_Missense_Mutation_p.G95C|PIAS3_uc001eod.1_5'Flank	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	104	Pro-rich.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GTTGGCCCCTGGCACCCTGCT	0.627			NA											13	90					1.61879e-10	2.9236e-10	0.001368	1	0
GJA8	2703	broad.mit.edu	37	1	147380357	147380357	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:147380357A>T	uc001epu.1	+	2	338	c.275A>T	c.(274-276)TAC>TTC	p.Y92F		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	92	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					TCCCTGATGTACGTGGGGCAC	0.657	Melanoma(76;1255 1795 8195 52096)		NA											9	55					0	0	0.006214	0	0
MRPS21	54460	broad.mit.edu	37	1	150280583	150280583	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:150280583G>T	uc001euk.2	+	3	267	c.185G>T	c.(184-186)CGG>CTG	p.R62L	MRPS21_uc001eul.2_Missense_Mutation_p.R62L	NM_031901	NP_114107	P82921	RT21_HUMAN	mitochondrial ribosomal protein S21	62					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Lung NSC(24;5.57e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGTGCCGGCGGATCTACAAC	0.547			NA											7	30					0.00307968	0.00367105	0.00308	1	0
LASS2	29956	broad.mit.edu	37	1	150940140	150940140	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:150940140C>G	uc001evy.2	-	6	906	c.519G>C	c.(517-519)CAG>CAC	p.Q173H	LASS2_uc001evz.2_Missense_Mutation_p.Q173H|LASS2_uc009wmh.2_Missense_Mutation_p.Q23H	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	173	Lumenal (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAACTCATACCTGTATGGGAT	0.468	Ovarian(75;371 1295 4880 12077 18753)		NA											28	175					0	0	0.001786	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151206944	151206944	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:151206944T>A	uc001exj.2	+	8	1363	c.911T>A	c.(910-912)CTC>CAC	p.L304H	PIP5K1A_uc001exi.2_Missense_Mutation_p.L291H|PIP5K1A_uc010pcu.1_Missense_Mutation_p.L292H|PIP5K1A_uc001exk.2_Missense_Mutation_p.L291H|PIP5K1A_uc010pcv.1_Missense_Mutation_p.L61H	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	304	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TACAACGCTCTCTGTAAGACC	0.408	Pancreas(80;36 1443 2325 16095 21302)		NA											9	68					0	0	0.006214	0	0
POGZ	23126	broad.mit.edu	37	1	151377695	151377695	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:151377695G>C	uc001eyd.1	-	19	4122	c.3816C>G	c.(3814-3816)GTC>GTG	p.V1272V	POGZ_uc001eye.1_Silent_p.V1219V|POGZ_uc010pdb.1_Silent_p.V1263V|POGZ_uc001eyf.1_Silent_p.V1228V|POGZ_uc010pdc.1_Silent_p.V1210V|POGZ_uc009wmv.1_Silent_p.V1177V|POGZ_uc010pdd.1_Silent_p.V763V	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1272	DDE.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAGTTCTTGACAGTTCTTT	0.478			NA											17	178					0	0	0.00499	0	0
FLG	2312	broad.mit.edu	37	1	152278945	152278945	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:152278945A>G	uc001ezu.1	-	3	8453	c.8417T>C	c.(8416-8418)GTA>GCA	p.V2806A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2806	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGAGCTATCTACCGAATGCTC	0.597			NA							Ichthyosis				20	318					0	0	0.002222	0	0
FLG	2312	broad.mit.edu	37	1	152280577	152280577	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:152280577G>T	uc001ezu.1	-	3	6821	c.6785C>A	c.(6784-6786)TCT>TAT	p.S2262Y		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2262	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGGACGCAGACCCAGACCG	0.582			NA							Ichthyosis				25	195					4.26978e-12	7.96464e-12	0.00333	1	0
LCE2C	353140	broad.mit.edu	37	1	152648701	152648701	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:152648701C>A	uc001fah.2	+	2	265	c.210C>A	c.(208-210)GGC>GGA	p.G70G		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	70	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGCTGGTGGCTGCTCCCTGA	0.667			NA											17	93					1.02788e-11	1.90175e-11	0.00499	1	0
S100A7A	338324	broad.mit.edu	37	1	153390625	153390625	+	Missense_Mutation	SNP	C	C	T	rs146005479		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:153390625C>T	uc001fbt.1	+	2	124	c.67C>T	c.(67-69)CGT>TGT	p.R23C		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	23	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATACACCGGACGTGATGGCAA	0.458			NA											14	101					0	0	0.003163	0	0
FCRL5	83416	broad.mit.edu	37	1	157490895	157490895	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:157490895C>A	uc001fqu.2	-	11	2585	c.2427G>T	c.(2425-2427)CTG>CTT	p.L809L	FCRL5_uc009wsm.2_Silent_p.L809L	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	809	Extracellular (Potential).|Ig-like C2-type 8.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GCTCTGCAGTCAGAGAGAGGT	0.542			NA											10	73					1.33987e-11	2.47093e-11	0.008291	1	0
FCRL1	115350	broad.mit.edu	37	1	157772257	157772257	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:157772257C>A	uc001frg.2	-	4	630	c.517G>T	c.(517-519)GTG>TTG	p.V173L	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.V173L|FCRL1_uc001fri.2_Missense_Mutation_p.V173L|FCRL1_uc001frj.2_Intron	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	173	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTCTCCCTCACTGAAGGAATC	0.488	GBM(54;482 1003 11223 30131 35730)		NA											9	55					0.000274275	0.000355681	0.004482	1	0
CD1B	910	broad.mit.edu	37	1	158299803	158299803	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:158299803C>A	uc001frx.2	-	3	554	c.446G>T	c.(445-447)TGT>TTT	p.C149F	CD1B_uc001frw.2_Missense_Mutation_p.C42F	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	149	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					GGAAGGCACACATGAAGCATT	0.473			NA											28	119					2.4375e-19	4.79065e-19	0.007291	1	0
OR6Y1	391112	broad.mit.edu	37	1	158517516	158517516	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:158517516C>A	uc010pil.1	-	1	380	c.380G>T	c.(379-381)CGC>CTC	p.R127L		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGCTACATAGCGGTCAAAGGC	0.468			NA											5	40					1.06961e-07	1.76868e-07	0.00308	1	0
OR10Z1	128368	broad.mit.edu	37	1	158577045	158577045	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:158577045C>G	uc010pio.1	+	1	817	c.817C>G	c.(817-819)CTT>GTT	p.L273V		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					GAGAGATCAGCTTATTGCCAT	0.468			NA											30	209					0	0	0.002836	0	0
FCER1A	2205	broad.mit.edu	37	1	159272653	159272653	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:159272653G>T	uc001ftq.2	+	3	164	c.65G>T	c.(64-66)GGC>GTC	p.G22V		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	22						integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GCTCCAGATGGCGTGTTAGCA	0.468			NA											17	126					1.01871e-10	1.85161e-10	0.008871	1	0
NHLH1	4807	broad.mit.edu	37	1	160340859	160340859	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:160340859A>G	uc001fwa.2	+	2	780	c.338A>G	c.(337-339)AAG>AGG	p.K113R		NM_005598	NP_005589	Q02575	HEN1_HUMAN	nescient helix loop helix 1	113	Helix-loop-helix motif.				cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_cancers(52;7.11e-19)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AAGCTCTCCAAGATTGAGATT	0.622			NA											11	49					0	0	0.001368	0	0
FCER1G	2207	broad.mit.edu	37	1	161188691	161188691	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:161188691G>A	uc001fyz.1	+	5	244	c.219G>A	c.(217-219)CAG>CAA	p.Q73Q	FCER1G_uc001fza.1_Silent_p.Q74Q	NM_004106	NP_004097	P30273	FCERG_HUMAN	Fc fragment of IgE, high affinity I, receptor	73	ITAM.|Cytoplasmic (Potential).				platelet activation	integral to plasma membrane					0	all_cancers(52;1.35e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Benzylpenicilloyl Polylysine(DB00895)	CCAGGAACCAGGAGACTTACG	0.562			NA											6	57					0	0	0.001168	0	0
FCGR2A	2212	broad.mit.edu	37	1	161487915	161487915	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:161487915G>C	uc001gan.2	+	7	984	c.931G>C	c.(931-933)GAC>CAC	p.D311H	FCGR2A_uc001gam.2_Missense_Mutation_p.D310H|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCCTCCCAACGACCATGTCAA	0.428			NA											5	52					0	0	0.001168	0	0
DDR2	4921	broad.mit.edu	37	1	162745481	162745481	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:162745481C>A	uc001gcf.2	+	16	2361	c.1896C>A	c.(1894-1896)CTC>CTA	p.L632L	DDR2_uc001gcg.2_Silent_p.L632L	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	632	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TGTCTCGGCTCAAGGACCCAA	0.408	NSCLC(161;314 2006 8283 19651 23192)		NA											14	93					1.05317e-09	1.86355e-09	0.00245	1	0
SELP	6403	broad.mit.edu	37	1	169565348	169565348	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:169565348C>T	uc001ggi.3	-	12	1981	c.1916G>A	c.(1915-1917)GGG>GAG	p.G639E	SELP_uc001ggh.2_Missense_Mutation_p.G474E|SELP_uc009wvr.2_Missense_Mutation_p.G639E	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	639	Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	ACATTGCACCCCTGGAGTAGG	0.468			NA											15	145					0	0	0.003163	0	0
SELP	6403	broad.mit.edu	37	1	169581475	169581475	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:169581475G>T	uc001ggi.3	-	6	1006	c.941C>A	c.(940-942)GCC>GAC	p.A314D	SELP_uc001ggh.2_Missense_Mutation_p.A149D|SELP_uc009wvr.2_Missense_Mutation_p.A314D	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	314	Extracellular (Potential).|Sushi 2.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TGGGGCTGGGGCTGTCCATAC	0.493			NA											9	49					6.40141e-05	8.8683e-05	0.000978	1	0
SELP	6403	broad.mit.edu	37	1	169586396	169586396	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:169586396C>A	uc001ggi.3	-	3	416	c.351G>T	c.(349-351)TGG>TGT	p.W117C	SELP_uc001ggh.2_5'UTR|SELP_uc009wvr.2_Missense_Mutation_p.W117C	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	117	Extracellular (Potential).|C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CATTATCAGCCCAGTTCTCAG	0.488			NA											14	142					3.27435e-08	5.51879e-08	0.00245	1	0
RC3H1	149041	broad.mit.edu	37	1	173947753	173947753	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:173947753C>A	uc001gju.3	-	6	1062	c.975G>T	c.(973-975)CAG>CAT	p.Q325H	RC3H1_uc010pms.1_Missense_Mutation_p.Q325H|RC3H1_uc001gjv.2_Missense_Mutation_p.Q325H|RC3H1_uc010pmt.1_Missense_Mutation_p.Q325H	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	325					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						AGGCTGGAGTCTGCAACTTAA	0.363			NA											5	28					1.23904e-05	1.80687e-05	0.000602	1	0
TNN	63923	broad.mit.edu	37	1	175049508	175049508	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:175049508C>A	uc001gkl.1	+	4	1107	c.994C>A	c.(994-996)CGT>AGT	p.R332S	TNN_uc010pmx.1_Missense_Mutation_p.R332S	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	332	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGTCACCCTGCGTAACGTCAA	0.552			NA											8	44					5.18039e-06	7.8153e-06	0.00308	1	0
ASTN1	460	broad.mit.edu	37	1	177030247	177030247	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:177030247T>C	uc001glc.2	-	2	650	c.438A>G	c.(436-438)GAA>GAG	p.E146E	ASTN1_uc001glb.1_Silent_p.E146E|ASTN1_uc001gld.1_Silent_p.E146E|ASTN1_uc009wwx.1_Silent_p.E146E	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	146					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCAGCTCCTCTTCTGCCGACT	0.498			NA											18	78					0	0	0.007413	0	0
FAM5B	57795	broad.mit.edu	37	1	177249846	177249846	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:177249846C>G	uc001glf.2	+	8	1846	c.1534C>G	c.(1534-1536)CTG>GTG	p.L512V	FAM5B_uc001glg.2_Missense_Mutation_p.L407V	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	512						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CTTGCAGGACCTGGAGCTAAA	0.587			NA											5	36					0	0	0.000602	0	0
ABL2	27	broad.mit.edu	37	1	179077507	179077507	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:179077507C>A	uc001gmj.3	-	12	3182	c.2895G>T	c.(2893-2895)CAG>CAT	p.Q965H	ABL2_uc010pnf.1_Missense_Mutation_p.Q862H|ABL2_uc010png.1_Missense_Mutation_p.Q841H|ABL2_uc010pnh.1_Missense_Mutation_p.Q944H|ABL2_uc001gmg.3_Missense_Mutation_p.Q847H|ABL2_uc001gmi.3_Missense_Mutation_p.Q950H|ABL2_uc001gmh.3_Missense_Mutation_p.Q929H|ABL2_uc010pne.1_Missense_Mutation_p.Q826H	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	965	Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	AGGATGTGACCTGATGCTCAG	0.532			NA	T	ETV6	AML								12	51					7.03913e-09	1.21342e-08	0.001368	1	0
FAM5C	339479	broad.mit.edu	37	1	190234075	190234075	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:190234075G>C	uc001gse.1	-	4	770	c.538C>G	c.(538-540)CTA>GTA	p.L180V	FAM5C_uc010pot.1_Missense_Mutation_p.L78V	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	180						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GAAGCGGCTAGCTGATGTAGC	0.463			NA											7	46					0	0	0.00308	0	0
KCNT2	343450	broad.mit.edu	37	1	196395110	196395110	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:196395110A>T	uc001gtd.1	-	11	1053	c.993T>A	c.(991-993)TAT>TAA	p.Y331*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.Y331*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.Y331*|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Nonsense_Mutation_p.Y331*|KCNT2_uc009wyv.1_Nonsense_Mutation_p.Y306*	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	331	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						AAATCACCACATAATAATCCT	0.338			NA											4	35					0	0	0.000248	0	0
ASPM	259266	broad.mit.edu	37	1	197073483	197073483	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:197073483C>G	uc001gtu.2	-	18	5155	c.4898G>C	c.(4897-4899)CGC>CCC	p.R1633P	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1633	IQ 4.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GACAGCAGAGCGTGTTTTCTG	0.363			NA											10	73					0	0	0.008291	0	0
PTPRC	5788	broad.mit.edu	37	1	198682150	198682150	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:198682150C>A	uc001gur.1	+	12	1414	c.1234C>A	c.(1234-1236)CCC>ACC	p.P412T	PTPRC_uc001gus.1_Missense_Mutation_p.P364T|PTPRC_uc001gut.1_Missense_Mutation_p.P251T|PTPRC_uc009wzf.1_Missense_Mutation_p.P300T|PTPRC_uc010ppg.1_Missense_Mutation_p.P348T	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	412	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TACCTGGAATCCCCCTCAAAG	0.318			NA											8	82					5.4927e-09	9.52628e-09	0.004482	1	0
ADORA1	134	broad.mit.edu	37	1	203134389	203134389	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:203134389G>T	uc001gze.1	+	4	775	c.342G>T	c.(340-342)CGG>CGT	p.R114R	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Silent_p.R114R|ADORA1_uc010pqg.1_Missense_Mutation_p.R46S|ADORA1_uc009xak.1_Missense_Mutation_p.V40L|ADORA1_uc010pqh.1_Silent_p.R147R	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	114	Cytoplasmic (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TCTCCCCCAGGTACAAGATGG	0.652			NA											7	23					1.06961e-07	1.76868e-07	0.00308	1	0
MYBPH	4608	broad.mit.edu	37	1	203144711	203144711	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:203144711G>T	uc001gzh.1	-	1	232	c.173C>A	c.(172-174)TCC>TAC	p.S58Y	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	58					cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		AGTGGCTGTGGAGGCTGTAGG	0.657	NSCLC(32;174 1025 14462 23899 42933)		NA											16	133					4.96729e-08	8.33507e-08	0.008871	1	0
PRELP	5549	broad.mit.edu	37	1	203452913	203452913	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:203452913G>T	uc001gzs.2	+	2	801	c.601G>T	c.(601-603)GAT>TAT	p.D201Y	PRELP_uc001gzt.2_Missense_Mutation_p.D201Y	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	201	Poly-Leu.|LRR 5.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCTGCTCCTGGATCTCCAGCA	0.607			NA											16	97					6.72482e-11	1.2282e-10	0.003163	1	0
CDK18	5129	broad.mit.edu	37	1	205492412	205492412	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:205492412C>G	uc001hcr.2	+	2	336	c.117C>G	c.(115-117)AAC>AAG	p.N39K	CDK18_uc009xbk.1_Intron|CDK18_uc009xbl.1_RNA|CDK18_uc010pri.1_5'UTR|CDK18_uc001hcp.2_Missense_Mutation_p.N39K|CDK18_uc001hcq.2_Missense_Mutation_p.N39K|CDK18_uc010prj.1_5'UTR|CDK18_uc001hcs.2_5'UTR|CDK18_uc009xbm.1_5'Flank	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	37							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						AGCTCCACAACCGGCGGAATG	0.597	Pancreas(180;489 2072 28461 40831 44265)		NA											3	42					0	0	0.001168	0	0
CENPF	1063	broad.mit.edu	37	1	214815375	214815375	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:214815375G>T	uc001hkm.2	+	12	3868	c.3694G>T	c.(3694-3696)GAG>TAG	p.E1232*		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1308	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GAAGGAGAAGGAGTGCCTGCA	0.373	Colon(80;575 1284 11000 14801 43496)		NA											6	34					0.00116845	0.00142726	0.001168	1	0
USH2A	7399	broad.mit.edu	37	1	215847618	215847618	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:215847618A>T	uc001hku.1	-	63	14022	c.13635T>A	c.(13633-13635)CCT>CCA	p.P4545P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4545	Fibronectin type-III 31.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGATCTCCTGAGGACCCCTGG	0.473			NA								HNSCC(13;0.011)			14	94					0	0	0.001855	0	0
USH2A	7399	broad.mit.edu	37	1	216420508	216420508	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:216420508C>G	uc001hku.1	-	13	2615	c.2228G>C	c.(2227-2229)GGA>GCA	p.G743A	USH2A_uc001hkv.2_Missense_Mutation_p.G743A	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	743	Laminin EGF-like 4.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGGCTCACATCCAACATCATT	0.403			NA								HNSCC(13;0.011)			11	78					0	0	0.001368	0	0
EPRS	2058	broad.mit.edu	37	1	220195837	220195837	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:220195837A>G	uc001hly.1	-	9	1237	c.967T>C	c.(967-969)TGG>CGG	p.W323R	EPRS_uc010puf.1_Missense_Mutation_p.W74R|EPRS_uc001hlz.1_Missense_Mutation_p.W323R|EPRS_uc009xdt.1_Missense_Mutation_p.W124R	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	323	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	ATTTCTTCCCACATTTGTAGA	0.338			NA											9	95					0	0	0.000978	0	0
CABC1	56997	broad.mit.edu	37	1	227152708	227152708	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:227152708A>T	uc001hqm.1	+	8	3604	c.185A>T	c.(184-186)GAT>GTT	p.D62V	CABC1_uc010pvp.1_Missense_Mutation_p.D25V|CABC1_uc001hqn.1_Missense_Mutation_p.D62V|CABC1_uc009xeq.1_Missense_Mutation_p.D10V|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	62					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CAGGGTCAGGATAAACATGAA	0.582			NA											5	24					0	0	0.000602	0	0
TAF5L	27097	broad.mit.edu	37	1	229730202	229730202	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:229730202C>T	uc001htq.2	-	5	1778	c.1612G>A	c.(1612-1614)GAC>AAC	p.D538N		NM_014409	NP_055224	O75529	TAF5L_HUMAN	PCAF associated factor 65 beta isoform a	538	WD 6.				histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				TTCCTGATGTCCCAGACGCGC	0.592			NA											6	27					0	0	0.001984	0	0
PGBD5	79605	broad.mit.edu	37	1	230492710	230492710	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:230492710T>C	uc010pwb.1	-	2	482	c.482A>G	c.(481-483)TAC>TGC	p.Y161C	PGBD5_uc001htv.2_Missense_Mutation_p.Y260C	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	161						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		CTGGACCTTGTAGAGCCCGTG	0.622			NA											13	45					0	0	0.001855	0	0
LYST	1130	broad.mit.edu	37	1	235969785	235969785	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:235969785T>C	uc001hxj.2	-	6	2826	c.2651A>G	c.(2650-2652)AAG>AGG	p.K884R	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.K884R	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	884					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTTCCGTCTCTTTGGATAAGC	0.398			NA							Chediak-Higashsyndrome				18	76					0	0	0.007413	0	0
NID1	4811	broad.mit.edu	37	1	236180456	236180456	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:236180456G>T	uc001hxo.2	-	10	2348	c.2246C>A	c.(2245-2247)ACG>AAG	p.T749K	NID1_uc009xgd.2_Intron	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	749	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	ACCCACACACGTTCCCTCATC	0.483			NA											14	77					0.00316338	0.00376688	0.003163	1	0
ACTN2	88	broad.mit.edu	37	1	236924413	236924413	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:236924413G>T	uc001hyf.2	+	20	2670	c.2466G>T	c.(2464-2466)ACG>ACT	p.T822T	ACTN2_uc001hyg.2_Silent_p.T614T|ACTN2_uc009xgi.1_Silent_p.T822T|ACTN2_uc010pxu.1_Silent_p.T511T|ACTN2_uc001hyh.2_Silent_p.T510T	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	822	EF-hand 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CTAGAGAGACGGCTGACACCG	0.542			NA											10	51					0.000151284	0.000205083	0.001855	1	0
ACTN2	88	broad.mit.edu	37	1	236924444	236924444	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:236924444G>T	uc001hyf.2	+	20	2701	c.2497G>T	c.(2497-2499)GCC>TCC	p.A833S	ACTN2_uc001hyg.2_Missense_Mutation_p.A625S|ACTN2_uc009xgi.1_Missense_Mutation_p.A833S|ACTN2_uc010pxu.1_Missense_Mutation_p.A522S|ACTN2_uc001hyh.2_Missense_Mutation_p.A521S	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	833					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GCAGGTCATCGCCTCCTTCCG	0.517			NA											8	50					0.00829132	0.00961116	0.008291	1	0
RYR2	6262	broad.mit.edu	37	1	237659966	237659966	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:237659966A>G	uc001hyl.1	+	20	2237	c.2117A>G	c.(2116-2118)TAC>TGC	p.Y706C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	706	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TATTCTCCCTACCCTGGAGGG	0.517			NA											6	61					0	0	0.001168	0	0
RYR2	6262	broad.mit.edu	37	1	237711850	237711850	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:237711850G>T	uc001hyl.1	+	26	3146	c.3026G>T	c.(3025-3027)CGG>CTG	p.R1009L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1009	Cytoplasmic (By similarity).|2.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGTGGGCGCGGGATCGAATC	0.468			NA											4	22					0.00024832	0.000325365	0.000248	1	0
RYR2	6262	broad.mit.edu	37	1	237730037	237730038	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:237730037_237730038GG>TT	uc001hyl.1	+	28	3505_3506	c.3385_3386GG>TT	c.(3385-3387)GGC>TTC	p.G1129F		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1129	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCAGGAGCTTGGCTCAGATGAA	0.53			NA											20	103					0	0	0.004672	0	0
RYR2	6262	broad.mit.edu	37	1	237777524	237777524	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:237777524G>C	uc001hyl.1	+	37	5216	c.5096G>C	c.(5095-5097)CGT>CCT	p.R1699P		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1699	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTTTGCTGCGTGCTGGCTAC	0.552			NA											3	29					0	0	0.004672	0	0
RYR2	6262	broad.mit.edu	37	1	237811774	237811774	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:237811774C>T	uc001hyl.1	+	49	7493	c.7373C>T	c.(7372-7374)GCG>GTG	p.A2458V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2458	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACATGTCTGCGGGGTTTTGC	0.458			NA											3	11					0	0	0.000248	0	0
CHRM3	1131	broad.mit.edu	37	1	240071400	240071400	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:240071400C>A	uc001hyp.2	+	5	1428	c.649C>A	c.(649-651)CCT>ACT	p.P217T		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	217	Extracellular (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GAGAACTGTGCCTCCGGGAGA	0.488			NA											22	121					8.04996e-18	1.57397e-17	0.001882	1	0
RGS7	6000	broad.mit.edu	37	1	240975308	240975309	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:240975308_240975309CC>AA	uc001hyv.2	-	14	1321_1322	c.991_992GG>TT	c.(991-993)GGT>TTT	p.G331F	RGS7_uc010pyh.1_Missense_Mutation_p.G305F|RGS7_uc010pyj.1_Missense_Mutation_p.G247F|RGS7_uc001hyu.2_Missense_Mutation_p.G331F|RGS7_uc009xgn.1_Missense_Mutation_p.G278F|RGS7_uc001hyw.2_Missense_Mutation_p.G331F|RGS7_uc001hyt.2_Missense_Mutation_p.G163F	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	331					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CATGCCAAAACCCCATCGTTTT	0.381			NA											8	78					0	0	0.004672	0	0
KMO	8564	broad.mit.edu	37	1	241725627	241725627	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:241725627G>T	uc009xgp.2	+	7	675	c.610G>T	c.(610-612)GGA>TGA	p.G204*	KMO_uc001hyy.2_Nonsense_Mutation_p.G204*|KMO_uc009xgo.1_Nonsense_Mutation_p.G204*	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	204					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			ACCTAAGAACGGAGATGTAAG	0.473			NA											17	127					8.34094e-07	1.30514e-06	0.008871	1	0
PLD5	200150	broad.mit.edu	37	1	242253272	242253272	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:242253272C>A	uc001hzn.1	-	10	1622	c.1495G>T	c.(1495-1497)GCC>TCC	p.A499S	PLD5_uc001hzl.3_Missense_Mutation_p.A437S|PLD5_uc001hzm.3_Missense_Mutation_p.A289S|PLD5_uc001hzo.1_Missense_Mutation_p.A407S			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	499						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AAGGTTTTGGCATACGGTGAA	0.478			NA											31	149					7.61165e-28	1.52502e-27	0.003755	1	0
VN1R5	317705	broad.mit.edu	37	1	247419455	247419455	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:247419455C>A	uc010pyu.1	+	1	82	c.82C>A	c.(82-84)CTT>ATT	p.L28I		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	28	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			CACAGATATCCTTTGCTTTAA	0.328	GBM(98;63 1399 4825 21305 33017)		NA											9	64					5.4927e-09	9.52628e-09	0.004482	1	0
NLRP3	114548	broad.mit.edu	37	1	247588721	247588721	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:247588721C>A	uc001icr.2	+	5	2114	c.1976C>A	c.(1975-1977)ACC>AAC	p.T659N	NLRP3_uc001ics.2_Missense_Mutation_p.T659N|NLRP3_uc001icu.2_Missense_Mutation_p.T659N|NLRP3_uc001icw.2_Missense_Mutation_p.T659N|NLRP3_uc001icv.2_Missense_Mutation_p.T659N|NLRP3_uc010pyw.1_Missense_Mutation_p.T657N|NLRP3_uc001ict.1_Missense_Mutation_p.T657N	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	659					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AATCTCTCCACCAGAATGGAC	0.493			NA											7	36					1.06961e-07	1.76868e-07	0.00308	1	0
NLRP3	114548	broad.mit.edu	37	1	247608039	247608039	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:247608039T>G	uc001icr.2	+	10	3065	c.2927T>G	c.(2926-2928)CTG>CGG	p.L976R	NLRP3_uc001ics.2_Missense_Mutation_p.L919R|NLRP3_uc001icu.2_Missense_Mutation_p.L976R|NLRP3_uc001icw.2_Missense_Mutation_p.L919R|NLRP3_uc001icv.2_Missense_Mutation_p.L862R|NLRP3_uc010pyw.1_Missense_Mutation_p.L954R	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	976	LRR 9.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AAGCTGAGCCTGGGCAACAAT	0.562			NA											5	52					0	0	0.000602	0	0
OR2C3	81472	broad.mit.edu	37	1	247694964	247694964	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:247694964G>T	uc009xgy.2	-	2	1212	c.850C>A	c.(850-852)CCT>ACT	p.P284T	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TTCAGCGCAGGAGTGACTACG	0.532			NA											5	41					3.59834e-05	5.08422e-05	0.001168	1	0
OR2G3	81469	broad.mit.edu	37	1	247768905	247768905	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:247768905G>T	uc010pyz.1	+	1	18	c.18G>T	c.(16-18)GAG>GAT	p.E6D		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGGCAATGAGAGTTCCCTAA	0.463			NA											8	48					7.48243e-07	1.17892e-06	0.006214	1	0
OR2W3	343171	broad.mit.edu	37	1	248059679	248059679	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:248059679C>A	uc001idp.1	+	3	1060	c.791C>A	c.(790-792)GCC>GAC	p.A264D	OR2W3_uc010pzb.1_Missense_Mutation_p.A264D	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CAGCCAGGAGCCAGTTCTTCC	0.532			NA											7	66					0.000274275	0.000355681	0.004482	1	0
OR2AK2	391191	broad.mit.edu	37	1	248129102	248129102	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:248129102T>C	uc010pzd.1	+	1	469	c.469T>C	c.(469-471)TGC>CGC	p.C157R	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GAAGATCTGCTGCCTCATGGT	0.423	Melanoma(45;390 1181 23848 28461 41504)		NA											21	152					0	0	0.001882	0	0
OR2M5	127059	broad.mit.edu	37	1	248308455	248308455	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:248308455A>G	uc010pze.1	+	1	6	c.6A>G	c.(4-6)GCA>GCG	p.A2A		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TCATCATGGCATGGGAGAATC	0.403			NA											14	116					0	0	0.00245	0	0
OR2M2	391194	broad.mit.edu	37	1	248344004	248344004	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:248344004G>T	uc010pzf.1	+	1	717	c.717G>T	c.(715-717)ACG>ACT	p.T239T		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AAGCTTTCACGACCTGTTCCT	0.488			NA											44	158					9.14704e-12	1.70066e-11	0.00874	1	0
OR2T3	343173	broad.mit.edu	37	1	248637465	248637465	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:248637465A>T	uc001iel.1	+	1	814	c.814A>T	c.(814-816)ACA>TCA	p.T272S		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCCTACCACACAGCTGAGCA	0.542			NA											12	200					0	0	0.004007	0	0
AKR1E2	83592	broad.mit.edu	37	10	4872893	4872893	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:4872893A>G	uc001ihi.2	+	2	181	c.66A>G	c.(64-66)GCA>GCG	p.A22A	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Silent_p.A22A|AKR1E2_uc001ihh.1_Silent_p.A22A|AKR1E2_uc009xhw.2_Silent_p.A22A|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Silent_p.A22A	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	22						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						TGACCGAGGCAGTGAAAGAGG	0.507	NSCLC(43;343 1097 20371 28813 45509)		NA											8	69					0	0	0.004482	0	0
TUBAL3	79861	broad.mit.edu	37	10	5436254	5436254	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:5436254T>A	uc001ihy.2	-	4	607	c.567A>T	c.(565-567)GTA>GTT	p.V189V	TUBAL3_uc001ihz.2_Silent_p.V149V	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	189					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						TATAAGGCTCTACCACAGCAG	0.512			NA											13	30					0	0	0.001368	0	0
IL15RA	3601	broad.mit.edu	37	10	6001727	6001727	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:6001727G>T	uc001iiv.2	-	5	688	c.606C>A	c.(604-606)AGC>AGA	p.S202R	IL15RA_uc001iiu.2_Missense_Mutation_p.S50R|IL15RA_uc010qau.1_Missense_Mutation_p.S169R|IL15RA_uc001iiw.2_Missense_Mutation_p.S166R|IL15RA_uc001iix.2_Missense_Mutation_p.S133R|IL15RA_uc001iiy.2_Missense_Mutation_p.S50R	NM_002189	NP_002180	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha isoform 1	202	Extracellular (Potential).				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity				0						CAGTGGTGTCGCTGTGGCCCT	0.577			NA											3	20					0.004672	0.00544907	0.004672	1	0
USP6NL	9712	broad.mit.edu	37	10	11504534	11504534	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:11504534C>T	uc001ikt.3	-	15	2714	c.2393G>A	c.(2392-2394)AGT>AAT	p.S798N	USP6NL_uc001iks.1_Missense_Mutation_p.S815N	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	798						intracellular	Rab GTPase activator activity				0						TCCAGATGGACTGGCATCTTC	0.537			NA											10	66					0	0	0.008291	0	0
PLXDC2	84898	broad.mit.edu	37	10	20290820	20290820	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:20290820A>G	uc001iqg.1	+	2	866	c.229A>G	c.(229-231)ACG>GCG	p.T77A	PLXDC2_uc001iqh.1_Missense_Mutation_p.T77A	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	77	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						GGCGGTAGACACGAACCGAGC	0.537			NA											3	28					0	0	0.000248	0	0
C10orf140	387640	broad.mit.edu	37	10	21804386	21804386	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:21804386C>A	uc009xkd.2	-	4	4619	c.2366G>T	c.(2365-2367)CGA>CTA	p.R789L	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	708						nucleus	nucleotide binding			ovary(1)	1						AAGGACAGGTCGCTTTCCCAG	0.448			NA											9	91					1.76689e-08	3.00478e-08	0.006214	1	0
GPR158	57512	broad.mit.edu	37	10	25887285	25887285	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:25887285G>A	uc001isj.2	+	11	2790	c.2730G>A	c.(2728-2730)AAG>AAA	p.K910K	GPR158_uc001isk.2_Silent_p.K285K	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	910	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CAAGCGCCAAGGAGAAGACTC	0.473			NA											15	95					0	0	0.003163	0	0
MYO3A	53904	broad.mit.edu	37	10	26286106	26286106	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:26286106A>T	uc001isn.2	+	6	787	c.427A>T	c.(427-429)AAC>TAC	p.N143Y	MYO3A_uc009xko.1_Missense_Mutation_p.N143Y|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.N143Y|MYO3A_uc001ism.2_Missense_Mutation_p.N143Y	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	143	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						ACATTTGCATAACAACAAAAC	0.313			NA											3	46					0	0	0.000248	0	0
KIAA1462	57608	broad.mit.edu	37	10	30336559	30336559	+	Silent	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:30336559C>G	uc001iux.2	-	1	242	c.183G>C	c.(181-183)GCG>GCC	p.A61A	KIAA1462_uc001iuy.2_Silent_p.A61A|KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc009xle.1_Silent_p.A61A	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	61										ovary(4)	4						GTCCTTTCCCCGCGGACGTCT	0.677			NA											7	58					0	0	0.00308	0	0
NRP1	8829	broad.mit.edu	37	10	33496628	33496628	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:33496628T>C	uc001iwx.3	-	10	2154	c.1631A>G	c.(1630-1632)AAC>AGC	p.N544S	NRP1_uc001iwv.3_Missense_Mutation_p.N544S|NRP1_uc009xlz.2_Missense_Mutation_p.N544S|NRP1_uc001iww.3_Missense_Mutation_p.N363S|NRP1_uc001iwy.3_Missense_Mutation_p.N544S|NRP1_uc001iwz.2_Missense_Mutation_p.N544S|NRP1_uc001ixa.2_Missense_Mutation_p.N544S|NRP1_uc001ixb.1_Missense_Mutation_p.N544S	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	544	Extracellular (Potential).|F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	ATCATAGTTGTTGTTGCCCTC	0.488	Melanoma(104;886 1489 44640 45944 51153)		NA											10	83					0	0	0.001368	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37451742	37451742	+	Silent	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:37451742C>G	uc001iza.1	+	17	1899	c.1800C>G	c.(1798-1800)GCC>GCG	p.A600A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	656						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAAATAAAGCCTTGGAATTGA	0.318			NA											12	57					0	0	0.001855	0	0
RET	5979	broad.mit.edu	37	10	43608348	43608348	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:43608348C>A	uc001jal.2	+	9	1886	c.1696C>A	c.(1696-1698)CCC>ACC	p.P566T	RET_uc001jak.1_Missense_Mutation_p.P566T|RET_uc010qez.1_Missense_Mutation_p.P312T	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	566	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CAAGACCTGCCCCGACGGCCA	0.602	Melanoma(102;360 522 3376 9752 9881 14372 17251 18341 20876 24662 34807 43144 48149)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				4	29					0.000602214	0.000754262	0.000602	1	0
FAM21C	253725	broad.mit.edu	37	10	46254832	46254832	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:46254832G>T	uc001jcu.2	+	17	1717	c.1618G>T	c.(1618-1620)GAT>TAT	p.D540Y	FAM21C_uc001jcs.1_Missense_Mutation_p.D485Y|FAM21C_uc001jct.2_Missense_Mutation_p.D540Y|FAM21C_uc010qfi.1_Missense_Mutation_p.D516Y|FAM21C_uc010qfj.1_Intron|FAM21C_uc010qfk.1_5'UTR	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	540										ovary(1)	1						CTTATTTTCAGATGAGGAGGA	0.408			NA											6	41					0.00621372	0.00722496	0.006214	1	0
C10orf53	282966	broad.mit.edu	37	10	50901862	50901862	+	Missense_Mutation	SNP	T	T	A	rs147880636	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:50901862T>A	uc001jib.2	+	2	200	c.140T>A	c.(139-141)ATA>AAA	p.I47K	CHAT_uc010qgs.1_3'UTR|C10orf53_uc001jic.1_Missense_Mutation_p.I47K|C10orf53_uc001jid.1_Missense_Mutation_p.I47K	NM_001042427	NP_001035892	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53 isoform b	47											0		all_neural(218;0.107)				CTAGAGAAGATAGAAGACTGG	0.473			NA											5	53					0	0	0.001168	0	0
OGDHL	55753	broad.mit.edu	37	10	50953905	50953905	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:50953905T>C	uc001jie.2	-	11	1557	c.1415A>G	c.(1414-1416)TAT>TGT	p.Y472C	OGDHL_uc009xog.2_Missense_Mutation_p.Y499C|OGDHL_uc010qgt.1_Missense_Mutation_p.Y415C|OGDHL_uc010qgu.1_Missense_Mutation_p.Y263C|OGDHL_uc009xoh.2_Missense_Mutation_p.Y263C	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	472					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						ACTGCACACATATATCACAGC	0.587			NA											13	38					0	0	0.001368	0	0
MBL2	4153	broad.mit.edu	37	10	54527923	54527923	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:54527923G>A	uc001jjt.2	-	4	786	c.721C>T	c.(721-723)CTG>TTG	p.L241L		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	241	C-type lectin.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						CAGACGGCCAGATGGGAGGTG	0.493			NA											27	190					0	0	0.003954	0	0
PCDH15	65217	broad.mit.edu	37	10	55698648	55698648	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:55698648C>A	uc001jju.1	-	25	3695	c.3300G>T	c.(3298-3300)AGG>AGT	p.R1100S	PCDH15_uc010qhq.1_Missense_Mutation_p.R1105S|PCDH15_uc010qhr.1_Missense_Mutation_p.R1100S|PCDH15_uc010qhs.1_Missense_Mutation_p.R1112S|PCDH15_uc010qht.1_Missense_Mutation_p.R1107S|PCDH15_uc010qhu.1_Missense_Mutation_p.R1100S|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1100S|PCDH15_uc010qhw.1_Missense_Mutation_p.R1063S|PCDH15_uc010qhx.1_Missense_Mutation_p.R1029S|PCDH15_uc010qhy.1_Missense_Mutation_p.R1105S|PCDH15_uc010qhz.1_Missense_Mutation_p.R1100S|PCDH15_uc010qia.1_Missense_Mutation_p.R1078S|PCDH15_uc010qib.1_Missense_Mutation_p.R1078S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1100	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CATAGCTTGTCCTGGTCTCAT	0.373			NA								HNSCC(58;0.16)			7	52					5.18039e-06	7.8153e-06	0.00308	1	0
TMEM26	219623	broad.mit.edu	37	10	63170401	63170401	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:63170401G>A	uc001jlo.2	-	6	1155	c.786C>T	c.(784-786)TTC>TTT	p.F262F	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlp.1_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	262	Helical; (Potential).					integral to membrane					0	Prostate(12;0.0112)					CATCTTGTATGAAGACGCTGA	0.502			NA											7	17					0	0	0.001984	0	0
JMJD1C	221037	broad.mit.edu	37	10	64975022	64975022	+	Splice_Site	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:64975022C>A	uc001jmn.2	-	7	1315	c.1015_splice	c.e7+1	p.E339_splice	JMJD1C_uc001jml.2_Splice_Site_p.E120_splice|JMJD1C_uc001jmm.2_Splice_Site_p.E51_splice|JMJD1C_uc010qiq.1_Splice_Site_p.E157_splice|JMJD1C_uc009xpi.2_Splice_Site_p.E157_splice|JMJD1C_uc009xpj.1_Splice_Site|JMJD1C_uc001jmp.1_Splice_Site_p.E51_splice	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a						blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GTGGGTCCTACCTCCTCGTGA	0.308			NA											9	67					1.12685e-05	1.66247e-05	0.004482	1	0
JMJD1C	221037	broad.mit.edu	37	10	64976995	64976995	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:64976995G>A	uc001jmn.2	-	5	950	c.650C>T	c.(649-651)ACC>ATC	p.T217I	JMJD1C_uc001jml.2_5'UTR|JMJD1C_uc001jmm.2_5'UTR|JMJD1C_uc010qiq.1_Missense_Mutation_p.T35I|JMJD1C_uc009xpi.2_Missense_Mutation_p.T35I|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_5'UTR	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	217					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CATGGTGCGGGTGAAGAGATC	0.368			NA											9	77					0	0	0.006214	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332358	71332358	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:71332358C>A	uc001jpp.2	-	2	600	c.442G>T	c.(442-444)GCG>TCG	p.A148S		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	148					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						GGCTCCAGCGCGTACAAGCTG	0.682			NA											5	15					0.000602214	0.000754262	0.000602	1	0
RBP4	5950	broad.mit.edu	37	10	95360226	95360226	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:95360226G>C	uc001kit.2	-	4	363	c.279C>G	c.(277-279)GGC>GGG	p.G93G		NM_006744	NP_006735	P02753	RET4_HUMAN	retinol-binding protein 4, plasma precursor	93			G -> D (in RBP deficiency).		cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding				0		Colorectal(252;0.122)			Vitamin A(DB00162)	CTGTGAAGGTGCCCACCATGT	0.577	Pancreas(5;160 256 1117 46697 50185)		NA											7	36					0	0	0.00308	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98408476	98408476	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:98408476G>A	uc001kmq.2	-	7	1253	c.1125C>T	c.(1123-1125)CCC>CCT	p.P375P	PIK3AP1_uc001kmp.2_Silent_p.P197P	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	375						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CGATGGTGTTGGGGTAGTGGC	0.577			NA											3	27					0	0	0.004672	0	0
SORCS3	22986	broad.mit.edu	37	10	106907445	106907445	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:106907445C>A	uc001kyi.1	+	9	1600	c.1373C>A	c.(1372-1374)ACG>AAG	p.T458K		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	458	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGAACGACACGTACAACCTC	0.468	NSCLC(116;1497 1690 7108 13108 14106)		NA											3	32					0.00024832	0.000325365	0.000248	1	0
SORCS1	114815	broad.mit.edu	37	10	108367013	108367013	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:108367013G>C	uc001kym.2	-	23	3084	c.3076C>G	c.(3076-3078)CCT>GCT	p.P1026A	SORCS1_uc001kyl.2_Missense_Mutation_p.P1026A|SORCS1_uc009xxs.2_Missense_Mutation_p.P1026A|SORCS1_uc001kyn.1_Missense_Mutation_p.P1026A|SORCS1_uc001kyo.2_Missense_Mutation_p.P1026A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1026	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGTAAGCCAGGGAGCACCGCC	0.562			NA											4	25					0	0	0.000248	0	0
KCNK18	338567	broad.mit.edu	37	10	118957067	118957067	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:118957067G>T	uc010qsr.1	+	1	68	c.68G>T	c.(67-69)GGC>GTC	p.G23V		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	23	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CTCTTCCCTGGCCTCTGCTTC	0.632			NA											4	49					1.23904e-05	1.80687e-05	0.000602	1	0
PDZD8	118987	broad.mit.edu	37	10	119043175	119043175	+	Silent	SNP	C	C	A	rs147188948		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:119043175C>A	uc001lde.1	-	5	3268	c.3069G>T	c.(3067-3069)CTG>CTT	p.L1023L		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1023					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		AGCCCCTGTACAGATCACGAC	0.418			NA											9	118					1.12685e-05	1.66247e-05	0.004482	1	0
CPXM2	119587	broad.mit.edu	37	10	125506513	125506513	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:125506513G>T	uc001lhk.1	-	14	2363	c.2038C>A	c.(2038-2040)CGC>AGC	p.R680S	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	680					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TTCAGGAGGCGCCAGTAATCC	0.547			NA											9	153					0.00010058	0.00013651	0.001368	1	0
Unknown	0	broad.mit.edu	37	10	134623993	134623993	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:134623993T>A	uc010qux.1	-	49	6762	c.6762A>T	c.(6760-6762)AGA>AGT	p.R2254S		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.												NA						GGCCAACAGATCTAGGGGAGA	0.627			NA											6	29					0	0	0.001168	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643105	1643105	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:1643105G>T	uc009ycy.1	-	3	444	c.357C>A	c.(355-357)TCC>TCA	p.S119S		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	133	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCCCCACAGGAGCCACAGC	0.587			NA											6	76					6.5536e-12	1.22047e-11	0.00308	1	0
OR52K2	119774	broad.mit.edu	37	11	4470650	4470650	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:4470650C>A	uc001lyz.1	+	1	81	c.81C>A	c.(79-81)ATC>ATA	p.I27I		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	27	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCTGCACATCTGGATCTCCA	0.517			NA											8	57					5.4927e-09	9.52628e-09	0.004482	1	0
OR51T1	401665	broad.mit.edu	37	11	4904034	4904034	+	Missense_Mutation	SNP	G	G	T	rs151076376	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:4904034G>T	uc010qyp.1	+	1	986	c.986G>T	c.(985-987)CGC>CTC	p.R329L		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGACAATCCGCCAGGCTATG	0.483			NA											5	54					0.000602214	0.000754262	0.000602	1	0
OR52A1	23538	broad.mit.edu	37	11	5173072	5173072	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:5173072G>T	uc010qyy.1	-	1	528	c.528C>A	c.(526-528)GTC>GTA	p.V176V		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	176	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTGGGAGATGACTGTTGTGT	0.433			NA											4	53					0.00024832	0.000325365	0.000248	1	0
TRIM22	10346	broad.mit.edu	37	11	5729478	5729478	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:5729478G>T	uc001mbr.2	+	6	1126	c.849G>T	c.(847-849)CTG>CTT	p.L283L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Silent_p.L251L|TRIM22_uc009yes.2_Silent_p.L279L|TRIM22_uc010qzm.1_Silent_p.L111L|TRIM22_uc009yeu.2_Silent_p.L94L|OR56B1_uc001mbs.1_5'UTR|OR56B1_uc009yev.1_5'UTR	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	283	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TACCAGATCTGAGTGGGATGC	0.423	GBM(104;491 2336 5222)		NA											5	26					0.000602214	0.000754262	0.000602	1	0
OR56B1	387748	broad.mit.edu	37	11	5758676	5758676	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:5758676C>A	uc001mbt.1	+	1	930	c.930C>A	c.(928-930)GCC>GCA	p.A310A	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		TTAGGGCAGCCTTCCAAAAGG	0.418			NA											21	139					5.26018e-13	9.9759e-13	0.001882	1	0
OR52N5	390075	broad.mit.edu	37	11	5799256	5799256	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:5799256G>T	uc010qzn.1	-	1	609	c.609C>A	c.(607-609)GTC>GTA	p.V203V	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	203	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AGATTACATTGACCTTGATGC	0.423			NA											7	53					0.000274275	0.000355681	0.004482	1	0
HPX	3263	broad.mit.edu	37	11	6461961	6461961	+	Splice_Site	SNP	C	C	G	rs113971031		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:6461961C>G	uc001mdg.2	-	2	145	c.84_splice	c.e2-1	p.P28_splice	HPX_uc009yfc.2_Splice_Site|HPX_uc010rai.1_Splice_Site_p.P28_splice	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor						cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GGCACTAGTCCTAGGGAGAAC	0.517			NA											4	44					0	0	0.000248	0	0
OR2D3	120775	broad.mit.edu	37	11	6942649	6942649	+	Silent	SNP	T	T	C	rs146817618		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:6942649T>C	uc010rav.1	+	1	417	c.417T>C	c.(415-417)TAT>TAC	p.Y139Y		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATGACCGGTATGTGGCTGTCT	0.502			NA											6	91					0	0	0.00308	0	0
OR5P3	120066	broad.mit.edu	37	11	7847205	7847205	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:7847205C>T	uc010rbg.1	-	1	315	c.315G>A	c.(313-315)GTG>GTA	p.V105V		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TACCAAACGTCACTACAGAAC	0.552			NA											4	73					0	0	0.000602	0	0
RIC3	79608	broad.mit.edu	37	11	8158923	8158923	+	Splice_Site	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:8158923A>T	uc001mgd.2	-	4	575	c.521_splice	c.e4+1	p.S174_splice	RIC3_uc001mgb.2_Splice_Site|RIC3_uc001mgc.2_Splice_Site_p.R174_splice|RIC3_uc001mge.2_Intron|RIC3_uc010rbl.1_Splice_Site_p.S124_splice|RIC3_uc010rbm.1_Splice_Site_p.S174_splice|RIC3_uc009yfm.2_Intron|RIC3_uc009yfn.2_Intron	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3							endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		ATGAAAACCTACCTCTCACCA	0.294			NA											20	69					0	0	0.007413	0	0
HPS5	11234	broad.mit.edu	37	11	18313051	18313051	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:18313051C>A	uc001mod.1	-	16	2656	c.2378G>T	c.(2377-2379)AGT>ATT	p.S793I	HPS5_uc001moe.1_Missense_Mutation_p.S679I|HPS5_uc001mof.1_Missense_Mutation_p.S679I	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	793						cytosol				ovary(1)|pancreas(1)|skin(1)	3						AAGCTTGATACTCTCCTTCGC	0.388			NA							Hermansky-Pudlak_syndrome				5	27					0.000602214	0.000754262	0.000602	1	0
KIF18A	81930	broad.mit.edu	37	11	28098612	28098612	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:28098612T>C	uc001msc.2	-	10	1549	c.1367A>G	c.(1366-1368)TAC>TGC	p.Y456C		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	456					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						CTGTTGTTGGTAGAATGATTT	0.269			NA											10	42					0	0	0.006214	0	0
CCDC73	493860	broad.mit.edu	37	11	32636435	32636435	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:32636435G>A	uc001mtv.2	-	16	1473	c.1429C>T	c.(1429-1431)CAG>TAG	p.Q477*		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	477										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TTTTCATCCTGAGAAACAACA	0.328			NA											3	51					0	0	0.004672	0	0
LRP4	4038	broad.mit.edu	37	11	46894697	46894697	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:46894697C>A	uc001ndn.3	-	30	4683	c.4537G>T	c.(4537-4539)GAC>TAC	p.D1513Y	uc001ndl.2_RNA	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1513	Extracellular (Potential).|LDL-receptor class B 18.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CAACCCAGGTCTGTGTTGATG	0.547			NA											9	48					3.09899e-07	4.96537e-07	0.004482	1	0
LRP4	4038	broad.mit.edu	37	11	46898324	46898325	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:46898324_46898325CC>AA	uc001ndn.3	-	24	3480_3481	c.3334_3335GG>TT	c.(3334-3336)GGC>TTC	p.G1112F		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1112	Extracellular (Potential).|LDL-receptor class B 11.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ATGCTGTGAGCCATCCAGATTG	0.559			NA											4	94					0	0	0.004672	0	0
LRP4	4038	broad.mit.edu	37	11	46920180	46920180	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:46920180A>G	uc001ndn.3	-	7	871	c.725T>C	c.(724-726)CTG>CCG	p.L242P	LRP4_uc009ylh.1_Missense_Mutation_p.L193P	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	242	Extracellular (Potential).|LDL-receptor class A 6.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ATTGATGCACAGGCCACTGTC	0.577			NA											8	120					0	0	0.008291	0	0
C1QTNF4	114900	broad.mit.edu	37	11	47611633	47611633	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:47611633A>T	uc001ngc.2	-	2	997	c.730T>A	c.(730-732)TCG>ACG	p.S244T		NM_031909	NP_114115	Q9BXJ3	C1QT4_HUMAN	C1q and tumor necrosis factor related protein 4	244	C1q 2.					extracellular region					0						AGCTTAACCGACAGCGTCTTA	0.667			NA											4	23					0	0	0.000248	0	0
OR4C16	219428	broad.mit.edu	37	11	55340095	55340095	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:55340095G>T	uc010rih.1	+	1	492	c.492G>T	c.(490-492)TTG>TTT	p.L164F		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				CCCTGAGTTTGCCATTCTGTG	0.478			NA											11	96					5.50884e-06	8.26689e-06	0.001368	1	0
OR5L2	26338	broad.mit.edu	37	11	55595294	55595294	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:55595294C>A	uc001nhy.1	+	1	600	c.600C>A	c.(598-600)TTC>TTA	p.F200L		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CACTGCTGTTCCTGGTGGCCA	0.448			NA								HNSCC(27;0.073)			14	157					1.49906e-05	2.17766e-05	0.00245	1	0
OR5F1	338674	broad.mit.edu	37	11	55761380	55761380	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:55761380C>A	uc010riv.1	-	1	722	c.722G>T	c.(721-723)TGT>TTT	p.C241F		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GTGAGAGGCACACGTGGAGAA	0.507			NA											4	37					0.000602214	0.000754262	0.000602	1	0
OR8J3	81168	broad.mit.edu	37	11	55904510	55904510	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:55904510G>C	uc010riz.1	-	1	685	c.685C>G	c.(685-687)CGT>GGT	p.R229G		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TCTGGTGAACGTATCCTTAGA	0.363			NA											9	52					0	0	0.004482	0	0
OR8K5	219453	broad.mit.edu	37	11	55927529	55927529	+	Silent	SNP	G	G	T	rs147577134		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:55927529G>T	uc010rja.1	-	1	265	c.265C>A	c.(265-267)CGA>AGA	p.R89R		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATAGTATTTCGATCCACAACA	0.393			NA											8	68					7.48243e-07	1.17892e-06	0.006214	1	0
OR5T3	390154	broad.mit.edu	37	11	56020511	56020511	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:56020511C>A	uc010rjd.1	+	1	836	c.836C>A	c.(835-837)ACA>AAA	p.T279K		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	279	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ACTGGAGTGACAATTTATCAT	0.393			NA											15	97					2.31682e-05	3.32732e-05	0.003163	1	0
OR9G9	504191	broad.mit.edu	37	11	56468180	56468180	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:56468180T>G	uc010rjn.1	+	1	317	c.317T>G	c.(316-318)CTG>CGG	p.L106R		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTGCAGGGCTGGCCTATAGT	0.537			NA											5	74					0	0	0.000602	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799343	57799343	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:57799343C>T	uc010rjz.1	+	1	919	c.919C>T	c.(919-921)CGA>TGA	p.R307*	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				AGCTCTGGGTCGAGTCTTTTC	0.443			NA											4	59					0	0	0.000248	0	0
OR5B12	390191	broad.mit.edu	37	11	58207590	58207590	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:58207590A>T	uc010rkh.1	-	1	35	c.35T>A	c.(34-36)CTT>CAT	p.L12H		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TAACCCCACAAGGATGAATTC	0.448			NA											3	29					0	0	0.004672	0	0
GLYATL2	219970	broad.mit.edu	37	11	58604651	58604651	+	Splice_Site	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:58604651C>A	uc001nnd.3	-	5	445	c.314_splice	c.e5-1	p.G105_splice	GLYATL2_uc009ymq.2_Splice_Site_p.G105_splice	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2							mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TCTTGGCAACCTGGAGAAAGG	0.403			NA											9	74					1.12685e-05	1.66247e-05	0.004482	1	0
OR4D6	219983	broad.mit.edu	37	11	59225169	59225169	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:59225169G>C	uc010rku.1	+	1	736	c.736G>C	c.(736-738)GTG>CTG	p.V246L		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCACATGCTGGTGGTGACTCT	0.552			NA											16	50					0	0	0.004007	0	0
OR4D11	219986	broad.mit.edu	37	11	59271283	59271283	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:59271283C>T	uc001noa.1	+	1	235	c.235C>T	c.(235-237)CCT>TCT	p.P79S		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	79	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CACAACTGCTCCTAAAGTCTT	0.498			NA											18	94					0	0	0.00499	0	0
TCN1	6947	broad.mit.edu	37	11	59622151	59622151	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:59622151G>T	uc001noj.2	-	7	1193	c.1095C>A	c.(1093-1095)GCC>GCA	p.A365A		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	365					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCATTTTCTGGGCTTTCTCCA	0.378			NA											5	68					0.00198382	0.00238984	0.001984	1	0
MS4A7	58475	broad.mit.edu	37	11	60157028	60157028	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:60157028T>C	uc001npe.2	+	5	650	c.505T>C	c.(505-507)TAT>CAT	p.Y169H	MS4A7_uc001npf.2_Missense_Mutation_p.Y169H|MS4A7_uc001npg.2_Missense_Mutation_p.Y124H|MS4A7_uc001nph.2_Missense_Mutation_p.Y124H|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Missense_Mutation_p.Y124H	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	169	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						TTATCCAATATATGAAATCAA	0.418			NA											8	60					0	0	0.004482	0	0
C11orf9	745	broad.mit.edu	37	11	61539345	61539345	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:61539345C>A	uc001nsc.1	+	7	1132	c.1036C>A	c.(1036-1038)CCC>ACC	p.P346T	C11orf9_uc001nse.1_Missense_Mutation_p.P337T	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	346	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CTACCTGGACCCCAACTACCA	0.602			NA											16	68					3.32936e-07	5.31948e-07	0.006122	1	0
SLC22A25	387601	broad.mit.edu	37	11	62931450	62931450	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:62931450G>T	uc001nwr.1	-	9	1490	c.1490C>A	c.(1489-1491)CCC>CAC	p.P497H	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	497	Helical; Name=12; (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						GATGATCCAGGGCAGGGGTCG	0.512			NA											13	86					1.5842e-08	2.71441e-08	0.001855	1	0
PLCB3	5331	broad.mit.edu	37	11	64023045	64023045	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:64023045G>T	uc001nzb.2	+	7	554	c.554G>T	c.(553-555)CGG>CTG	p.R185L	PLCB3_uc009ypg.1_Missense_Mutation_p.R185L|PLCB3_uc009yph.1_Missense_Mutation_p.R118L|PLCB3_uc009ypi.2_Missense_Mutation_p.R185L	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	185					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GACAAGAAGCGGGTGGAGACT	0.617			NA											10	44					0.00621372	0.00722496	0.006214	1	0
SNX15	29907	broad.mit.edu	37	11	64795011	64795011	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:64795011T>C	uc001oci.3	+	4	655	c.2T>C	c.(1-3)ATG>ACG	p.M1T	SNX15_uc009ypy.2_Missense_Mutation_p.M1T|SNX15_uc001ocj.2_Missense_Mutation_p.M1T|SNX15_uc001ock.2_Missense_Mutation_p.M1T	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	1	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						CTCGGTTTCATGTCCCGCCAG	0.701	Esophageal Squamous(56;269 1304 3324 8253)		NA									OREG0021069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	41					0	0	0.001984	0	0
CPT1A	1374	broad.mit.edu	37	11	68540772	68540772	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:68540772G>T	uc001oog.3	-	14	1871	c.1701C>A	c.(1699-1701)GAC>GAA	p.D567E	CPT1A_uc001oof.3_Missense_Mutation_p.D567E|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	567	Cytoplasmic (Potential).|Coenzyme A binding (By similarity).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GCACAAAGGCGTCTGGGCTCG	0.527			NA											3	30					1.024e-07	1.70817e-07	0.000602	1	0
PPFIA1	8500	broad.mit.edu	37	11	70171046	70171046	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:70171046G>T	uc001opo.2	+	4	658	c.460G>T	c.(460-462)GTG>TTG	p.V154L	PPFIA1_uc001opn.1_Missense_Mutation_p.V154L|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_5'Flank	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	154					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TCCAGCAGGCGTGTCCAGCGA	0.498			NA											6	101					0.00198382	0.00238984	0.001984	1	0
ARHGEF17	9828	broad.mit.edu	37	11	73071467	73071467	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:73071467G>T	uc001otu.2	+	11	4330	c.4309G>T	c.(4309-4311)GAG>TAG	p.E1437*		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1437					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						AACCAAGCTGGAGCTGTGCGC	0.627			NA											8	109					0.000274275	0.000355681	0.004482	1	0
PCF11	51585	broad.mit.edu	37	11	82882867	82882867	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:82882867G>T	uc001ozx.3	+	9	4013	c.3668G>T	c.(3667-3669)AGT>ATT	p.S1223I		NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	1223					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						AAGGTTCTGAGTGGTGTTGCT	0.323			NA											7	55					8.12818e-05	0.000110582	0.001984	1	0
FZD4	8322	broad.mit.edu	37	11	86663317	86663317	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:86663317C>A	uc001pce.2	-	2	787	c.481G>T	c.(481-483)GGG>TGG	p.G161W	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	161	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TCACCTGGCCCTTCCATGCAC	0.527			NA											8	59					1.06961e-07	1.76868e-07	0.00308	1	0
FAT3	120114	broad.mit.edu	37	11	92616229	92616229	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:92616229A>T	uc001pdj.3	+	23	12624	c.12607A>T	c.(12607-12609)AAG>TAG	p.K4203*	FAT3_uc001pdi.3_Nonsense_Mutation_p.K643*	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4203	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTGCTTAACAAGAGCAATGG	0.642			NA								TCGA Ovarian(4;0.039)			6	68					0	0	0.00308	0	0
YAP1	10413	broad.mit.edu	37	11	102033253	102033253	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:102033253A>T	uc001pgt.2	+	3	1009	c.639A>T	c.(637-639)ACA>ACT	p.T213T	YAP1_uc001pgs.2_Silent_p.T213T|YAP1_uc001pgu.2_Silent_p.T213T|YAP1_uc001pgv.2_Silent_p.T213T|YAP1_uc010ruo.1_Silent_p.T35T|YAP1_uc001pgw.2_Silent_p.T35T	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	213					cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		TGAACGTCACAGCCCCCACCA	0.488	Colon(50;247 1103 7861 28956)		NA											7	118					0	0	0.00308	0	0
MMP7	4316	broad.mit.edu	37	11	102394117	102394117	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:102394117T>C	uc001phb.2	-	5	676	c.629A>G	c.(628-630)TAT>TGT	p.Y210C		NM_002423	NP_002414	P09237	MMP7_HUMAN	matrix metalloproteinase 7 preproprotein	210					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(1)	1	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		AGTTGCAGCATACAGGAAGTT	0.333			NA											4	55					0	0	0.000602	0	0
MMP10	4319	broad.mit.edu	37	11	102649462	102649462	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:102649462G>A	uc001phg.1	-	4	537	c.515C>T	c.(514-516)TCT>TTT	p.S172F		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	172					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		GCCATCAAAAGAGTAAAAGTC	0.373			NA											3	38					0	0	0.004672	0	0
ATM	472	broad.mit.edu	37	11	108218052	108218052	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:108218052G>A	uc001pkb.1	+	59	9016	c.8631G>A	c.(8629-8631)TTG>TTA	p.L2877L	ATM_uc009yxr.1_Silent_p.L2877L|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Silent_p.L1529L	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2877	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGAATATCTTGATAAATGAGC	0.308			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			3	41					0	0	0.004672	0	0
EXPH5	23086	broad.mit.edu	37	11	108384381	108384381	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:108384381C>G	uc001pkk.2	-	6	1964	c.1853G>C	c.(1852-1854)GGA>GCA	p.G618A	EXPH5_uc010rvy.1_Missense_Mutation_p.G430A|EXPH5_uc010rvz.1_Missense_Mutation_p.G462A|EXPH5_uc010rwa.1_Missense_Mutation_p.G542A	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	618					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTGAGCAATTCCAAATGAGGA	0.418			NA											8	87					0	0	0.00308	0	0
NCAM1	4684	broad.mit.edu	37	11	113102911	113102911	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:113102911C>A	uc009yyq.1	+	12	1678	c.984C>A	c.(982-984)GGC>GGA	p.G328G		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	420	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGCTACAGGGCCCTGTGGCTG	0.537			NA											3	11					6.4e-05	8.8683e-05	0.004672	1	0
DRD2	1813	broad.mit.edu	37	11	113285099	113285099	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:113285099C>G	uc001pnz.2	-	5	1129	c.808G>C	c.(808-810)GTG>CTG	p.V270L	DRD2_uc010rwv.1_Missense_Mutation_p.V269L|DRD2_uc001poa.3_Missense_Mutation_p.V270L|DRD2_uc001pob.3_Intron|DRD2_uc009yyr.1_Missense_Mutation_p.V270L	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	270	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GCACTTACCACTCTCCGCCTG	0.567			NA											11	134					0	0	0.000978	0	0
CADM1	23705	broad.mit.edu	37	11	115085438	115085438	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:115085438C>T	uc001ppi.3	-	7	1013	c.884G>A	c.(883-885)GGG>GAG	p.G295E	CADM1_uc001ppf.3_Missense_Mutation_p.G295E|CADM1_uc001ppk.3_Missense_Mutation_p.G295E|CADM1_uc001ppj.3_Missense_Mutation_p.G295E|CADM1_uc001ppl.2_Missense_Mutation_p.G295E|CADM1_uc001pph.3_Missense_Mutation_p.G47E	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	295	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CAGGTTGGGCCCAGACAGTAC	0.473			NA											13	63					0	0	0.00245	0	0
CEP164	22897	broad.mit.edu	37	11	117280506	117280506	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:117280506G>C	uc001prc.2	+	30	4068	c.3921G>C	c.(3919-3921)AAG>AAC	p.K1307N	CEP164_uc001prb.2_Missense_Mutation_p.K1302N|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.K732N	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1307					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GGGACCCTAAGAGCACCCCCA	0.652			NA											16	113					0	0	0.004007	0	0
ATP5L	10632	broad.mit.edu	37	11	118279714	118279714	+	Splice_Site	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:118279714G>A	uc001psx.2	+	3	491	c.214_splice	c.e3-1	p.E72_splice		NM_006476	NP_006467	O75964	ATP5L_HUMAN	ATP synthase, H+ transporting, mitochondrial F0						ATP catabolic process|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|protein binding				0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)		TCTTTTTTCAGGAAGCTGTGC	0.333			NA											6	23					0	0	0.001168	0	0
GRIK4	2900	broad.mit.edu	37	11	120531062	120531062	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:120531062C>T	uc001pxn.2	+	3	322	c.35C>T	c.(34-36)CCT>CTT	p.P12L	GRIK4_uc009zav.1_Missense_Mutation_p.P12L|GRIK4_uc009zaw.1_Missense_Mutation_p.P12L|GRIK4_uc009zax.1_Missense_Mutation_p.P12L	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	12					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GTGCTGCTTCCTGCGTGGCTC	0.632			NA									OREG0021424	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	51					0	0	0.001984	0	0
SORL1	6653	broad.mit.edu	37	11	121429299	121429299	+	Splice_Site	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:121429299G>T	uc001pxx.2	+	20	2744	c.2664_splice	c.e20-1	p.G888_splice		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ATTTTCGCTAGGGTGATGTTC	0.473			NA											11	71					0.000219431	0.000293264	0.00245	1	0
ASAM	79827	broad.mit.edu	37	11	122954456	122954456	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:122954456A>G	uc001pyt.2	-	4	847	c.488T>C	c.(487-489)GTG>GCG	p.V163A		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	163	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		CCAGTAATACACAATGGGCTC	0.498			NA											4	60					0	0	0.000248	0	0
OR6X1	390260	broad.mit.edu	37	11	123624810	123624810	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:123624810G>T	uc010rzy.1	-	1	417	c.417C>A	c.(415-417)TGC>TGA	p.C139*		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	139	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CCAGCTGCAGGCAGAGTTTGC	0.522			NA											3	39					0.00024832	0.000325365	0.000248	1	0
KIRREL3	84623	broad.mit.edu	37	11	126319004	126319004	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:126319004G>T	uc001qea.2	-	8	1258	c.897C>A	c.(895-897)TAC>TAA	p.Y299*	KIRREL3_uc001qeb.2_Nonsense_Mutation_p.Y299*|KIRREL3_uc001qec.1_Nonsense_Mutation_p.Y299*	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	299	Extracellular (Potential).|Ig-like C2-type 3.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CTGTGGTCCTGTACACCTCTC	0.607			NA											8	73					2.17888e-05	3.14511e-05	0.006214	1	0
ETS1	2113	broad.mit.edu	37	11	128356001	128356001	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:128356001G>C	uc010sbs.1	-	4	760	c.444C>G	c.(442-444)GCC>GCG	p.A148A	ETS1_uc001qej.2_Silent_p.A192A|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Silent_p.A148A	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	148					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		ATTCTGGATAGGCTGGGTTGA	0.408			NA											6	57					0	0	0.001168	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130340918	130340918	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:130340918C>T	uc010scd.1	+	6	1824	c.1824C>T	c.(1822-1824)TCC>TCT	p.S608S		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	608	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCAAGTACTCCGGCGTGTCTC	0.617			NA											6	67					0	0	0.001984	0	0
LOC100288778	100288778	broad.mit.edu	37	12	90858	90858	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:90858G>C	uc010scy.1	+	10	1279	c.724G>C	c.(724-726)GAC>CAC	p.D242H	LOC100288778_uc010scz.1_RNA|LOC100288778_uc010sdd.1_3'UTR|LOC100288778_uc010sde.1_Missense_Mutation_p.D242H|LOC100288778_uc010sdf.1_Missense_Mutation_p.D242H|LOC100288778_uc010sdg.1_Missense_Mutation_p.D242H|LOC100288778_uc010sdh.1_RNA					SubName: Full=Actin nucleation promoting factor; Flags: Fragment;												0						CCGCGTGTCAGACTCCATCCC	0.642			NA											4	5					0	0	0.000602	0	0
LOC100288778	100288778	broad.mit.edu	37	12	90911	90911	+	Missense_Mutation	SNP	G	G	C	rs142471649	by1000genomes	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:90911G>C	uc010scy.1	+	10	1332	c.777G>C	c.(775-777)AAG>AAC	p.K259N	LOC100288778_uc010scz.1_RNA|LOC100288778_uc010sdd.1_3'UTR|LOC100288778_uc010sde.1_Missense_Mutation_p.K259N|LOC100288778_uc010sdf.1_Missense_Mutation_p.K259N|LOC100288778_uc010sdg.1_Missense_Mutation_p.K259N|LOC100288778_uc010sdh.1_RNA					SubName: Full=Actin nucleation promoting factor; Flags: Fragment;												0						ACGAGGACAAGGACGACTGGG	0.647			NA											4	9					0	0	0.000602	0	0
IQSEC3	440073	broad.mit.edu	37	12	274680	274680	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:274680C>A	uc001qhw.1	+	7	1887	c.1881C>A	c.(1879-1881)TTC>TTA	p.F627L	IQSEC3_uc001qhu.1_Missense_Mutation_p.F627L	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	930	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GCATGCAGTTCCAGCTCTTTG	0.493			NA											7	63					8.12818e-05	0.000110582	0.001984	1	0
CACNA2D4	93589	broad.mit.edu	37	12	2022194	2022194	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:2022194C>T	uc001qjp.2	-	3	652	c.421G>A	c.(421-423)GTC>ATC	p.V141I	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.V141I	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	141	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AGTACCTGGACCGCCTCGACT	0.602	Colon(2;101 179 21030 23310 28141)		NA											3	10					0	0	0.004672	0	0
LRP6	4040	broad.mit.edu	37	12	12334236	12334236	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:12334236C>T	uc001rah.3	-	6	1256	c.1114G>A	c.(1114-1116)GGC>AGC	p.G372S	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.G372S	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	372	LDL-receptor class B 6.|Extracellular (Potential).|Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				TAGATGTAGCCTTCCACAGGA	0.453			NA											8	58					0	0	0.00308	0	0
PLCZ1	89869	broad.mit.edu	37	12	18865880	18865880	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:18865880A>T	uc010sid.1	-	6	801	c.610T>A	c.(610-612)TGG>AGG	p.W204R	PLCZ1_uc001rdv.3_Missense_Mutation_p.W100R|PLCZ1_uc001rdw.3_Intron|PLCZ1_uc001rdu.1_5'UTR|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	204	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					GCTCCATCCCAGCAGTCAATC	0.373			NA											5	41					0	0	0.000602	0	0
PDE3A	5139	broad.mit.edu	37	12	20766475	20766475	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:20766475G>T	uc001reh.1	+	3	1132	c.1110G>T	c.(1108-1110)GTG>GTT	p.V370V		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	370				HGLITDLLADPSLPPNVC -> TASLPTSWQTLLFHQTCA (in Ref. 3 and 4).	lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CACCAAACGTGTGCACATCCT	0.557			NA											6	47					0.00116845	0.00142726	0.001168	1	0
PRICKLE1	144165	broad.mit.edu	37	12	42866307	42866307	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:42866307C>T	uc010skv.1	-	2	299	c.12G>A	c.(10-12)GAG>GAA	p.E4E	PRICKLE1_uc001rnl.2_Silent_p.E4E|PRICKLE1_uc010skw.1_Silent_p.E4E|PRICKLE1_uc001rnm.2_Silent_p.E4E|PRICKLE1_uc009zka.2_5'UTR	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	4					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		TGGGCTCCATCTCCAAAGGCA	0.463			NA											4	41					0	0	0.001168	0	0
ACVR1B	91	broad.mit.edu	37	12	52380697	52380697	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:52380697G>T	uc001rzn.2	+	7	1274	c.1232G>T	c.(1231-1233)TGG>TTG	p.W411L	ACVR1B_uc001rzl.2_Missense_Mutation_p.W411L|ACVR1B_uc001rzm.2_Missense_Mutation_p.W411L|ACVR1B_uc010snn.1_Missense_Mutation_p.W452L	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	411	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	CTTGTATATTGGGAGATTGCT	0.428			NA											11	83					2.80697e-09	4.92087e-09	0.000978	1	0
KRT73	319101	broad.mit.edu	37	12	53012247	53012247	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:53012247G>C	uc001sas.2	-	1	97	c.62C>G	c.(61-63)TCC>TGC	p.S21C		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	21	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		GAGCACAGCGGAGCAGCCGCT	0.637			NA											4	46					0	0	0.000602	0	0
OR9K2	441639	broad.mit.edu	37	12	55524048	55524048	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:55524048T>C	uc010spe.1	+	1	496	c.496T>C	c.(496-498)TGT>CGT	p.C166R		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	166	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						CACACGTCTGTGTACTCAGTT	0.468			NA											8	63					0	0	0.004482	0	0
MMP19	4327	broad.mit.edu	37	12	56234451	56234451	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:56234451C>A	uc001sib.2	-	4	641	c.520G>T	c.(520-522)GGG>TGG	p.G174W	MMP19_uc001sia.2_5'Flank|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_Missense_Mutation_p.G174C	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	174					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						TGTTGCCTACCAGGCCCATCA	0.522			NA											8	73					2.17888e-05	3.14511e-05	0.006214	1	0
DGKA	1606	broad.mit.edu	37	12	56330338	56330338	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:56330338A>G	uc001sij.2	+	2	315	c.51A>G	c.(49-51)CAA>CAG	p.Q17Q	DGKA_uc009zoc.1_Silent_p.Q17Q|DGKA_uc001sih.1_5'UTR|DGKA_uc001sii.1_5'UTR|DGKA_uc009zod.1_Silent_p.Q17Q|DGKA_uc009zoe.1_Silent_p.Q17Q|DGKA_uc001sik.2_Silent_p.Q17Q|DGKA_uc001sil.2_Silent_p.Q17Q|DGKA_uc001sim.2_Silent_p.Q17Q|DGKA_uc001sin.2_Silent_p.Q17Q|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_5'UTR	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	17					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	CCCAGCTGCAAAAATACATGG	0.527			NA											5	21					0	0	0.001168	0	0
LRP1	4035	broad.mit.edu	37	12	57548038	57548038	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:57548038G>T	uc001snd.2	+	7	1355	c.889G>T	c.(889-891)GTG>TTG	p.V297L	LRP1_uc001snc.1_Missense_Mutation_p.V297L	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	297	Extracellular (Potential).|LDL-receptor class B 1.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTTCTACTTTGTGGATGACAT	0.512			NA											8	90					0.00307968	0.00367105	0.00308	1	0
LRP1	4035	broad.mit.edu	37	12	57573723	57573723	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:57573723G>T	uc001snd.2	+	30	5591	c.5125G>T	c.(5125-5127)GTC>TTC	p.V1709F		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1709	Extracellular (Potential).|LDL-receptor class B 14.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGGCCTTGTCGTCCACCCTCT	0.622			NA											16	82					3.45872e-05	4.95473e-05	0.004007	1	0
KIF5A	3798	broad.mit.edu	37	12	57975705	57975705	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:57975705G>T	uc001sor.1	+	26	3170	c.2962G>T	c.(2962-2964)GCT>TCT	p.A988S	KIF5A_uc010srr.1_Missense_Mutation_p.A899S|uc001sos.2_5'Flank	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	988	Globular.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CGGCCCCTTGGCTTCCTACCA	0.537			NA											7	33					1.06961e-07	1.76868e-07	0.00308	1	0
NAV3	89795	broad.mit.edu	37	12	78400781	78400781	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:78400781A>T	uc001syp.2	+	8	1636	c.1463A>T	c.(1462-1464)AAG>ATG	p.K488M	NAV3_uc001syo.2_Missense_Mutation_p.K488M	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	488						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAAGAAGAGAAGGATCAGGTG	0.393			NA								HNSCC(70;0.22)			8	34					0	0	0.004482	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449967	85449967	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:85449967A>T	uc001tac.2	+	8	1507	c.1396A>T	c.(1396-1398)AAA>TAA	p.K466*	LRRIQ1_uc001tab.1_Nonsense_Mutation_p.K466*|LRRIQ1_uc001taa.1_Nonsense_Mutation_p.K441*	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	466										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AGTAAAGTTAAAAGAATCTAT	0.308			NA											4	29					0	0	0.000602	0	0
NTN4	59277	broad.mit.edu	37	12	96180796	96180796	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:96180796C>T	uc001tei.2	-	2	955	c.506G>A	c.(505-507)GGC>GAC	p.G169D	NTN4_uc009ztf.2_Missense_Mutation_p.G169D|NTN4_uc009ztg.2_Missense_Mutation_p.G132D	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	169	Laminin N-terminal.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ATCTTCCAGGCCAAATGTAGC	0.507			NA											4	48					0	0	0.000248	0	0
NEDD1	121441	broad.mit.edu	37	12	97328946	97328946	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:97328946G>C	uc001teu.3	+	7	1021	c.682G>C	c.(682-684)GAT>CAT	p.D228H	NEDD1_uc001tev.3_Missense_Mutation_p.D228H|NEDD1_uc010svc.1_Missense_Mutation_p.D139H|NEDD1_uc001tew.2_Missense_Mutation_p.D235H|NEDD1_uc001tex.2_Missense_Mutation_p.D139H	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	228	WD 6.				cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						CATAGGCTTGGATAAAAGAAT	0.363			NA											8	63					0	0	0.004482	0	0
NT5DC3	51559	broad.mit.edu	37	12	104200708	104200708	+	Splice_Site	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:104200708C>G	uc010swe.1	-	3	435	c.394_splice	c.e3-1	p.Y132_splice		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3								hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						CTGCTGGATACTAAGAAAGAA	0.428			NA											5	38					0	0	0.000602	0	0
WSCD2	9671	broad.mit.edu	37	12	108603991	108603991	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:108603991G>C	uc001tms.2	+	4	1335	c.591G>C	c.(589-591)ATG>ATC	p.M197I	WSCD2_uc001tmt.2_Missense_Mutation_p.M197I	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	197	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						AGTGCGACATGGAGTGCAAGG	0.682			NA											7	25					0	0	0.001984	0	0
PTPN11	5781	broad.mit.edu	37	12	112939999	112939999	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:112939999G>A	uc001ttx.2	+	14	2031	c.1651G>A	c.(1651-1653)GAC>AAC	p.D551N		NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	555					axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						TTCTCTAGCGGACCAGACGAG	0.453			NA	Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				6	62					0	0	0.00308	0	0
RASAL1	8437	broad.mit.edu	37	12	113553489	113553489	+	Silent	SNP	C	C	T	rs137930457	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:113553489C>T	uc001tum.1	-	11	1247	c.954G>A	c.(952-954)CTG>CTA	p.L318L	RASAL1_uc010syp.1_Silent_p.L318L|RASAL1_uc001tul.2_Silent_p.L318L|RASAL1_uc001tun.1_Silent_p.L318L|RASAL1_uc010syq.1_Silent_p.L318L|RASAL1_uc001tuo.3_Silent_p.L318L|RASAL1_uc010syr.1_Silent_p.L318L	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	318	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						AGCGCCCAGCCAGTCCCCGGC	0.627			NA											4	16					0	0	0.000248	0	0
RBM19	9904	broad.mit.edu	37	12	114377880	114377880	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:114377880C>A	uc009zwi.2	-	15	1967	c.1823G>T	c.(1822-1824)GGC>GTC	p.G608V	RBM19_uc001tvn.3_Missense_Mutation_p.G608V|RBM19_uc001tvm.2_Missense_Mutation_p.G608V	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	608	RRM 4.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCCAAAATGGCCGAAGGTCTC	0.632			NA											14	66					1.52009e-12	2.85898e-12	0.003163	1	0
TBX3	6926	broad.mit.edu	37	12	115112511	115112511	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:115112511G>A	uc001tvt.1	-	7	2193	c.1229C>T	c.(1228-1230)CCC>CTC	p.P410L	TBX3_uc001tvu.1_Missense_Mutation_p.P390L	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	410					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CTTGACCGCGGGGCTGCCCTT	0.701			NA											3	9					0	0	0.004672	0	0
FBXO21	23014	broad.mit.edu	37	12	117604703	117604703	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:117604703C>A	uc001twk.2	-	8	1232	c.1193G>T	c.(1192-1194)CGG>CTG	p.R398L	FBXO21_uc001twj.2_Missense_Mutation_p.R398L|FBXO21_uc009zwq.2_Intron|FBXO21_uc001twl.1_Missense_Mutation_p.R11L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	398					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		AAAACCTTACCGCTTCCCCAG	0.458	GBM(168;452 2038 13535 17701 43680)		NA											9	55					0.00448238	0.00529312	0.004482	1	0
ABCB9	23457	broad.mit.edu	37	12	123428991	123428991	+	Missense_Mutation	SNP	C	C	A	rs147318444		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:123428991C>A	uc001udm.3	-	7	1637	c.1327G>T	c.(1327-1329)GGC>TGC	p.G443C	ABCB9_uc010tai.1_Missense_Mutation_p.G50C|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Intron|ABCB9_uc010taj.1_Missense_Mutation_p.G443C|ABCB9_uc001udp.2_Missense_Mutation_p.G443C|ABCB9_uc001udq.2_Missense_Mutation_p.G225C|ABCB9_uc001udr.2_Missense_Mutation_p.G443C	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	443	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		ATGAGGTTGCCGCTGGTCATC	0.582	Ovarian(49;786 1333 9175 38236)		NA											4	74					0.000602214	0.000754262	0.000602	1	0
RNF17	56163	broad.mit.edu	37	13	25362201	25362201	+	Silent	SNP	C	C	T	rs79685389		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:25362201C>T	uc001upr.2	+	7	728	c.687C>T	c.(685-687)TAC>TAT	p.Y229Y	RNF17_uc010tdd.1_Silent_p.Y88Y|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Silent_p.Y229Y|RNF17_uc001ups.2_Silent_p.Y168Y|RNF17_uc001upq.1_Silent_p.Y229Y	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	229					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTAAAAGCTACATTGAAGAGA	0.308			NA											5	66					0	0	0.000602	0	0
ATP8A2	51761	broad.mit.edu	37	13	26128042	26128042	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:26128042C>A	uc001uqk.2	+	12	1311	c.1169C>A	c.(1168-1170)GCC>GAC	p.A390D	ATP8A2_uc010tdi.1_Missense_Mutation_p.A350D|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.A350D	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	350	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TATACTCAAGCCCTTTTCATA	0.363			NA											15	67					2.31682e-05	3.32732e-05	0.003163	1	0
FLT1	2321	broad.mit.edu	37	13	29008344	29008344	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:29008344G>A	uc001usb.3	-	5	812	c.527C>T	c.(526-528)ACT>ATT	p.T176I	FLT1_uc010aar.1_Missense_Mutation_p.T176I|FLT1_uc001usc.3_Missense_Mutation_p.T176I|FLT1_uc010tdp.1_Missense_Mutation_p.T176I	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	176	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGGGATCAAAGTGTCAAGTGG	0.413			NA											9	38					0	0	0.006214	0	0
SOHLH2	54937	broad.mit.edu	37	13	36748988	36748988	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:36748988G>A	uc001uvj.2	-	7	749	c.660C>T	c.(658-660)TGC>TGT	p.C220C	SOHLH2_uc010tei.1_Silent_p.C297C	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	220	Basic motif.				cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		GCTGCTCACAGCAATATTTGA	0.403			NA											9	42					0	0	0.006214	0	0
CCNA1	8900	broad.mit.edu	37	13	37015285	37015285	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:37015285G>C	uc001uvr.3	+	7	1479	c.1129G>C	c.(1129-1131)GAT>CAT	p.D377H	CCNA1_uc010teo.1_Missense_Mutation_p.D333H|CCNA1_uc010abq.2_Missense_Mutation_p.D333H|CCNA1_uc010abp.2_Missense_Mutation_p.D333H|CCNA1_uc001uvs.3_Missense_Mutation_p.D376H|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	377					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		ACTTGAAGCAGATCCATTCTT	0.403			NA											6	45					0	0	0.001168	0	0
KIAA0564	23078	broad.mit.edu	37	13	42263515	42263515	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:42263515A>C	uc001uyj.2	-	34	4176	c.4106T>G	c.(4105-4107)ATA>AGA	p.I1369R		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1369						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		ACCAACAACTATTGTAGCATA	0.358			NA											6	27					0	0	0.001168	0	0
KIAA0564	23078	broad.mit.edu	37	13	42263517	42263517	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:42263517T>A	uc001uyj.2	-	34	4174	c.4104A>T	c.(4102-4104)ACA>ACT	p.T1368T		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1368						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		CAACAACTATTGTAGCATAAT	0.358			NA											5	28					0	0	0.000602	0	0
TSC22D1	8848	broad.mit.edu	37	13	45148670	45148670	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:45148670C>A	uc001uzn.3	-	1	2032	c.1541G>T	c.(1540-1542)GGT>GTT	p.G514V	TSC22D1_uc001uzo.1_Missense_Mutation_p.G514V	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	514	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		GAGGGTCACACCTTGGAGAGC	0.398			NA											13	83					4.3838e-07	6.98457e-07	0.001855	1	0
SPERT	220082	broad.mit.edu	37	13	46276958	46276958	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:46276958C>G	uc001van.1	+	2	204	c.124C>G	c.(124-126)CTA>GTA	p.L42V	SPERT_uc001vao.2_5'Flank	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	42						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		ATCTGAAAGCCTAGAAATTCC	0.438			NA											6	38					0	0	0.001168	0	0
ZC3H13	23091	broad.mit.edu	37	13	46542960	46542960	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:46542960C>G	uc010tfw.1	-	13	3725	c.3719G>C	c.(3718-3720)AGC>ACC	p.S1240T	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.S1240T|ZC3H13_uc001vat.1_Missense_Mutation_p.S1240T	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1240	Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GATTTCCAGGCTTTTTGTTTT	0.428	Esophageal Squamous(187;747 2077 11056 31291 44172)		NA											15	118					0	0	0.003163	0	0
INTS6	26512	broad.mit.edu	37	13	51942033	51942033	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:51942033T>C	uc001vfk.2	-	17	3092	c.2478A>G	c.(2476-2478)AAA>AAG	p.K826K	INTS6_uc001vfi.2_Silent_p.K510K|INTS6_uc001vfj.2_Silent_p.K813K|INTS6_uc001vfl.2_Silent_p.K648K	NM_012141	NP_036273	Q9UL03	INT6_HUMAN	integrator complex subunit 6 isoform a	826					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		TTCTTTCATATTCTTAAAGCA	0.264			NA											4	20					0	0	0.000248	0	0
THSD1	55901	broad.mit.edu	37	13	52952445	52952445	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:52952445C>A	uc001vgo.2	-	5	2205	c.1660G>T	c.(1660-1662)GTG>TTG	p.V554L	THSD1_uc001vgp.2_Missense_Mutation_p.V501L|THSD1_uc010tgz.1_Missense_Mutation_p.V175L|THSD1_uc010aea.2_Missense_Mutation_p.V15L	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	554	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CTCTGAGACACGTGATACACT	0.517			NA											22	91					7.87624e-14	1.50884e-13	0.00278	1	0
MYCBP2	23077	broad.mit.edu	37	13	77663000	77663000	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:77663000T>A	uc001vkf.2	-	62	10669	c.10578A>T	c.(10576-10578)CTA>CTT	p.L3526L	MYCBP2_uc010aev.2_Silent_p.L2930L|MYCBP2_uc001vke.2_Silent_p.L146L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CAGATTTCCTTAGGGCCTGTT	0.348			NA											16	60					0	0	0.00499	0	0
MYCBP2	23077	broad.mit.edu	37	13	77669677	77669677	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:77669677C>G	uc001vkf.2	-	59	9992	c.9901G>C	c.(9901-9903)GAA>CAA	p.E3301Q	MYCBP2_uc010aev.2_Missense_Mutation_p.E2705Q|MYCBP2_uc001vke.2_5'Flank	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGGTGAGCTTCCATGGTGGGC	0.473			NA											3	54					0	0	0.004672	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329568	88329568	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:88329568G>C	uc001vln.2	+	2	2144	c.1925G>C	c.(1924-1926)CGG>CCG	p.R642P	SLITRK5_uc010tic.1_Missense_Mutation_p.R401P	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	642	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCTGCGGTCCGGTTGAATAGC	0.622			NA											5	51					0	0	0.001984	0	0
DZIP1	22873	broad.mit.edu	37	13	96272154	96272154	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr13:96272154C>A	uc001vmk.2	-	10	2010	c.1158G>T	c.(1156-1158)AAG>AAT	p.K386N	DZIP1_uc001vml.2_Missense_Mutation_p.K386N	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	386					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			CCTTCTCTTTCTTGTGTTCTT	0.333			NA											25	96					2.41591e-17	4.7075e-17	0.004656	1	0
OR4K5	79317	broad.mit.edu	37	14	20389362	20389362	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:20389362T>C	uc010tkw.1	+	1	597	c.597T>C	c.(595-597)ATT>ATC	p.I199I		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAATACTAATTGTGGTCAATA	0.408			NA											18	164					0	0	0.007413	0	0
OR4N5	390437	broad.mit.edu	37	14	20612100	20612100	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:20612100T>A	uc010tla.1	+	1	206	c.206T>A	c.(205-207)CTG>CAG	p.L69Q		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TTGGCCTTACTGGATGCATCC	0.473			NA											52	141					0	0	0.00361	0	0
TTC5	91875	broad.mit.edu	37	14	20764550	20764550	+	Missense_Mutation	SNP	G	G	T	rs150011121		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:20764550G>T	uc001vwt.2	-	6	752	c.695C>A	c.(694-696)ACG>AAG	p.T232K	TTC5_uc001vwu.2_Missense_Mutation_p.T89K	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	232	TPR 4.				DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		AGGTCTTACCGTCGCCCTGTT	0.423			NA											8	172					4.68919e-08	7.89173e-08	0.008291	1	0
RPGRIP1	57096	broad.mit.edu	37	14	21794251	21794251	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:21794251G>T	uc001wag.2	+	16	2629	c.2629G>T	c.(2629-2631)GAT>TAT	p.D877Y	RPGRIP1_uc001wah.2_Missense_Mutation_p.D519Y|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001wak.2_Missense_Mutation_p.D352Y|RPGRIP1_uc010aim.2_Missense_Mutation_p.D260Y|RPGRIP1_uc001wal.2_Missense_Mutation_p.D236Y|RPGRIP1_uc001wam.2_Missense_Mutation_p.D194Y	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	877	C2.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TGTTTTTGATGATGAAGACTT	0.483			NA											10	22					0.000673444	0.000838851	0.008291	1	0
OR10G2	26534	broad.mit.edu	37	14	22102200	22102200	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:22102200C>A	uc010tmc.1	-	1	799	c.799G>T	c.(799-801)GCT>TCT	p.A267S		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TTGGAGCCAGCCCTAAGGTAG	0.552			NA											9	37					1.76689e-08	3.00478e-08	0.006214	1	0
CDH24	64403	broad.mit.edu	37	14	23517554	23517554	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:23517554C>A	uc001wil.2	-	13	2355	c.2095G>T	c.(2095-2097)GAC>TAC	p.D699Y	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Missense_Mutation_p.D661Y	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	699	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GCCGTGATGTCGAAGGCCTCG	0.522			NA											18	78					4.96729e-08	8.33507e-08	0.008871	1	0
PABPN1	8106	broad.mit.edu	37	14	23793489	23793489	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:23793489G>T	uc001wjk.2	+	6	2154	c.872G>T	c.(871-873)CGC>CTC	p.R291L	PABPN1_uc001wjh.3_Missense_Mutation_p.R318L|PABPN1_uc001wjj.2_Missense_Mutation_p.R291L	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	291	Interacts with PAPOLA (By similarity).|Necessary for homooligomerization.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CCCCGGGGTCGCGTCTACAGG	0.632			NA											15	50					1.52009e-12	2.85898e-12	0.003163	1	0
MYH7	4625	broad.mit.edu	37	14	23887531	23887531	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:23887531C>T	uc001wjx.2	-	30	4163	c.4057G>A	c.(4057-4059)GCC>ACC	p.A1353T	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1353	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCGGCCTTGGCCTCCGTCTCC	0.672			NA											5	60					0	0	0.000602	0	0
PSME2	5721	broad.mit.edu	37	14	24612835	24612835	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:24612835C>A	uc001wmj.2	-	10	663	c.598G>T	c.(598-600)GGG>TGG	p.G200W	FAM158A_uc001wmi.2_5'Flank|PSME2_uc001wmk.2_Missense_Mutation_p.G123W	NM_002818	NP_002809	Q9UL46	PSME2_HUMAN	proteasome activator subunit 2	200					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex					0				GBM - Glioblastoma multiforme(265;0.00839)		CTGAGCTCCCCATAGGCTGCC	0.597			NA											15	75					4.75885e-15	9.1473e-15	0.00499	1	0
NYNRIN	57523	broad.mit.edu	37	14	24883947	24883947	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:24883947G>A	uc001wpf.3	+	9	3310	c.2992G>A	c.(2992-2994)GAG>AAG	p.E998K		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	998					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						AGAGAAGGAGGAGAGGCAGGA	0.597			NA											3	22					0	0	0.004672	0	0
STRN3	29966	broad.mit.edu	37	14	31388178	31388178	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:31388178C>T	uc001wqu.2	-	9	1450	c.1234G>A	c.(1234-1236)GAG>AAG	p.E412K	STRN3_uc001wqv.2_Intron|STRN3_uc010tpj.1_Intron	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	412					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		GTACCTTCCTCTGCTCTTGCA	0.398			NA											28	94					0	0	0.008361	0	0
STRN3	29966	broad.mit.edu	37	14	31416470	31416470	+	Splice_Site	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:31416470C>A	uc001wqu.2	-	5	759	c.543_splice	c.e5-1	p.Q181_splice	STRN3_uc001wqv.2_Splice_Site_p.Q181_splice|STRN3_uc010tpj.1_Splice_Site	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1						negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		CTGAAGATACCTGTAAGAGAA	0.328			NA											14	47					2.23348e-06	3.41486e-06	0.004007	1	0
FSCB	84075	broad.mit.edu	37	14	44975221	44975221	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:44975221C>A	uc001wvn.2	-	1	1279	c.970G>T	c.(970-972)GCC>TCC	p.A324S		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	324	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		ACTAAAGGGGCCTCTTCAGCA	0.502			NA											11	56					6.40141e-05	8.8683e-05	0.000978	1	0
C14orf106	55320	broad.mit.edu	37	14	45705137	45705137	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:45705137T>C	uc001wwf.2	-	6	1687	c.1228A>G	c.(1228-1230)AAC>GAC	p.N410D	C14orf106_uc010anh.2_RNA	NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	410					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						CAATATATGTTAGTGACGTCT	0.308	Ovarian(187;620 2054 7273 12043 20532)		NA											3	31					0	0	0.000248	0	0
SYNE2	23224	broad.mit.edu	37	14	64421515	64421515	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:64421515G>T	uc001xgm.2	+	8	899	c.669G>T	c.(667-669)TTG>TTT	p.L223F	SYNE2_uc001xgk.2_Missense_Mutation_p.L223F|SYNE2_uc001xgl.2_Missense_Mutation_p.L223F	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	223	CH 2.|Cytoplasmic (Potential).|Actin-binding.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTCATGCCTTGCGACCAGACC	0.393			NA											4	49					2.56e-06	3.89312e-06	0.000248	1	0
SPTB	6710	broad.mit.edu	37	14	65259901	65259901	+	Missense_Mutation	SNP	C	C	A	rs150013838		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:65259901C>A	uc001xht.2	-	13	2534	c.2480G>T	c.(2479-2481)CGG>CTG	p.R827L	SPTB_uc001xhr.2_Missense_Mutation_p.R827L|SPTB_uc001xhs.2_Missense_Mutation_p.R827L|SPTB_uc001xhu.2_Missense_Mutation_p.R827L	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	827	Spectrin 6.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GTAGAGCTCCCGCAGGGCCTG	0.652			NA											4	46					0.000602214	0.000754262	0.000602	1	0
PCNX	22990	broad.mit.edu	37	14	71444226	71444226	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:71444226G>C	uc001xmo.2	+	6	1618	c.1172G>C	c.(1171-1173)CGG>CCG	p.R391P	PCNX_uc001xmn.3_Missense_Mutation_p.R391P|PCNX_uc010are.1_Missense_Mutation_p.R391P	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	391						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GGAACGGACCGGGACACTAAC	0.498			NA											4	43					0	0	0.000248	0	0
ENTPD5	957	broad.mit.edu	37	14	74439636	74439636	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:74439636G>A	uc010tuo.1	-	13	1289	c.978C>T	c.(976-978)TTC>TTT	p.F326F	ENTPD5_uc001xpi.2_Silent_p.F326F	NM_001249	NP_001240	O75356	ENTP5_HUMAN	ectonucleoside triphosphate diphosphohydrolase 5	326					'de novo' posttranslational protein folding|ATP metabolic process|cell growth|cell proliferation|glycolysis|protein N-linked glycosylation|regulation of phosphatidylinositol 3-kinase cascade	endoplasmic reticulum lumen	guanosine-diphosphatase activity|uridine-diphosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00394)		AGAAAGCATAGAAGGAACCTC	0.547			NA											14	174					0	0	0.004007	0	0
TMEM63C	57156	broad.mit.edu	37	14	77715676	77715676	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:77715676A>G	uc001xtf.2	+	21	2125	c.1913A>G	c.(1912-1914)AAC>AGC	p.N638S	TMEM63C_uc010asq.1_Missense_Mutation_p.N638S	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	638						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GATCGCTATAACATGTACTAC	0.537			NA											6	71					0	0	0.00308	0	0
ADCK1	57143	broad.mit.edu	37	14	78399723	78399723	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:78399723G>C	uc001xui.2	+	11	1660	c.1561G>C	c.(1561-1563)GCT>CCT	p.A521P	ADCK1_uc001xuj.2_Missense_Mutation_p.A453P|ADCK1_uc001xul.2_Missense_Mutation_p.A228P	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	528						extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GCTGTTCCCTGCTCCACTCTG	0.552			NA											4	69					0	0	0.000602	0	0
STON2	85439	broad.mit.edu	37	14	81744278	81744278	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:81744278C>A	uc010tvu.1	-	4	1578	c.1377G>T	c.(1375-1377)CTG>CTT	p.L459L	STON2_uc001xvk.1_Silent_p.L459L|STON2_uc010tvt.1_Silent_p.L256L	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	459	SHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		AATACAGCTGCAGGTAACCAG	0.483			NA											15	182					5.3912e-06	8.12256e-06	0.006122	1	0
C14orf102	55051	broad.mit.edu	37	14	90755074	90755074	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:90755074A>T	uc001xyi.1	-	11	2676	c.2645T>A	c.(2644-2646)CTG>CAG	p.L882Q	C14orf102_uc010atp.1_Missense_Mutation_p.L387Q|C14orf102_uc001xyj.1_Missense_Mutation_p.L651Q|C14orf102_uc001xyk.1_Missense_Mutation_p.L74Q	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	882							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		ACAGTCCTGCAGTGCGTGCTC	0.512			NA											5	30					0	0	0.001168	0	0
FBLN5	10516	broad.mit.edu	37	14	92353602	92353602	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:92353602T>A	uc001xzx.3	-	7	1147	c.674A>T	c.(673-675)TAC>TTC	p.Y225F	FBLN5_uc010aud.2_Missense_Mutation_p.Y230F|FBLN5_uc010aue.2_Missense_Mutation_p.Y266F	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	225	EGF-like 4; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				GAAAGAGCCGTAGGTGTTGAC	0.522			NA											8	85					0	0	0.006214	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964191	94964191	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:94964191T>G	uc001ydj.2	-	3	1340	c.544A>C	c.(544-546)AGT>CGT	p.S182R		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	182					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		GTTTTTTGACTGATAAAGTCA	0.383			NA											12	76					0	0	0.001368	0	0
DLK1	8788	broad.mit.edu	37	14	101195327	101195327	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:101195327C>A	uc001yhs.3	+	3	339	c.186C>A	c.(184-186)GGC>GGA	p.G62G	DLK1_uc001yhu.3_Silent_p.G62G	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	62	EGF-like 2.|Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				CCTCTCCCGGCTGCCTTCACG	0.622			NA											6	87					2.0095e-06	3.08069e-06	0.001984	1	0
HSP90AA1	3320	broad.mit.edu	37	14	102548655	102548655	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:102548655T>C	uc001yku.3	-	10	2072	c.1882A>G	c.(1882-1884)ATG>GTG	p.M628V	HSP90AA1_uc001ykv.3_Missense_Mutation_p.M750V	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	628					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	TTTGCTGCCATGTAACCCATT	0.443			NA											15	96					0	0	0.003163	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413236	105413236	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:105413236G>C	uc010axc.1	-	7	8672	c.8552C>G	c.(8551-8553)TCC>TGC	p.S2851C	AHNAK2_uc001ypx.2_Missense_Mutation_p.S2751C	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2851						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCTTGCATGGAGGGGAAGCT	0.617			NA											21	158					0	0	0.001523	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416310	105416310	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:105416310G>C	uc010axc.1	-	7	5598	c.5478C>G	c.(5476-5478)CCC>CCG	p.P1826P	AHNAK2_uc001ypx.2_Silent_p.P1726P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1826						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTTGAACTTGGGCATTTTGA	0.612			NA											19	320					0	0	0.008871	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418992	105418992	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr14:105418992C>T	uc010axc.1	-	7	2916	c.2796G>A	c.(2794-2796)AAG>AAA	p.K932K	AHNAK2_uc001ypx.2_Silent_p.K832K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	932						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTGGGGGCCCTTGAGGTCCA	0.622			NA											21	251					0	0	0.00278	0	0
GABRA5	2558	broad.mit.edu	37	15	27159994	27159994	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:27159994C>T	uc001zbd.1	+	8	881	c.542C>T	c.(541-543)CCG>CTG	p.P181L	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	181	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GAGGACTTCCCGATGGATGCG	0.448			NA											3	38					0	0	0.000248	0	0
GABRG3	2567	broad.mit.edu	37	15	27572050	27572050	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:27572050T>A	uc001zbg.1	+	4	531	c.365T>A	c.(364-366)ATG>AAG	p.M122K	GABRG3_uc001zbf.2_Missense_Mutation_p.M122K	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	122	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AACAGCAACATGGTGGGGTTA	0.448	NSCLC(114;800 1656 7410 37729 45293)		NA											4	43					0	0	0.000602	0	0
APBA2	321	broad.mit.edu	37	15	29346661	29346661	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:29346661G>T	uc001zck.2	+	3	781	c.574G>T	c.(574-576)GGC>TGC	p.G192C	APBA2_uc010azj.2_Missense_Mutation_p.G192C|APBA2_uc010uat.1_Missense_Mutation_p.G192C|APBA2_uc001zcl.2_Missense_Mutation_p.G192C|APBA2_uc010uas.1_Missense_Mutation_p.G192C	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	192	STXBP1-binding.			DEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPY RLRR -> MSPPSLRPMTRKKMVTMCQQRGLPGLLPRGGQR EHRRLPLPPEA (in Ref. 1; AAC39767).	nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CAGCAAAGAGGGCTACCAGGA	0.642			NA											7	17					5.18039e-06	7.8153e-06	0.00308	1	0
RYR3	6263	broad.mit.edu	37	15	33990137	33990137	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:33990137G>T	uc001zhi.2	+	40	6259	c.6189G>T	c.(6187-6189)CTG>CTT	p.L2063L	RYR3_uc010bar.2_Silent_p.L2063L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2063	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGAGAGTCCTGGGCATGCACG	0.458			NA											8	45					3.09899e-07	4.96537e-07	0.004482	1	0
RYR3	6263	broad.mit.edu	37	15	34015046	34015046	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:34015046C>A	uc001zhi.2	+	44	6820	c.6750C>A	c.(6748-6750)ATC>ATA	p.I2250I	RYR3_uc010bar.2_Silent_p.I2250I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2250	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCATTAAGATCTCTGAGAACC	0.577			NA											7	82					2.0095e-06	3.08069e-06	0.001984	1	0
MFAP1	4236	broad.mit.edu	37	15	44102041	44102041	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:44102041C>A	uc001zth.1	-	7	1143	c.959G>T	c.(958-960)CGG>CTG	p.R320L		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	320						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		GCCGTTTGCCCGAAGTTCAGC	0.443			NA											9	131					2.80697e-09	4.92087e-09	0.000978	1	0
SEMA6D	80031	broad.mit.edu	37	15	48056105	48056105	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:48056105T>C	uc010bek.2	+	10	1166	c.806T>C	c.(805-807)GTC>GCC	p.V269A	SEMA6D_uc001zvw.2_Missense_Mutation_p.V269A|SEMA6D_uc001zvx.1_Missense_Mutation_p.V269A|SEMA6D_uc001zvy.2_Missense_Mutation_p.V269A|SEMA6D_uc001zvz.2_Missense_Mutation_p.V269A|SEMA6D_uc001zwa.2_Missense_Mutation_p.V269A|SEMA6D_uc001zwb.2_Missense_Mutation_p.V269A|SEMA6D_uc001zwc.2_Missense_Mutation_p.V269A	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	269	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TCCCAGCGGGTCCTGGAGAAA	0.493			NA											12	72					0	0	0.000978	0	0
SEMA6D	80031	broad.mit.edu	37	15	48063273	48063273	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:48063273A>G	uc010bek.2	+	19	2873	c.2513A>G	c.(2512-2514)AAC>AGC	p.N838S	SEMA6D_uc001zvw.2_Missense_Mutation_p.N776S|SEMA6D_uc001zvy.2_Missense_Mutation_p.N838S|SEMA6D_uc001zvz.2_Missense_Mutation_p.N782S|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.N776S|SEMA6D_uc001zwc.2_Missense_Mutation_p.N763S	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	838	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CATGACTACAACACGTCTTTC	0.463			NA											7	47					0	0	0.001984	0	0
GRINL1A	81488	broad.mit.edu	37	15	58001046	58001046	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:58001046A>T	uc002aet.3	+	2	388	c.248A>T	c.(247-249)AAG>ATG	p.K83M	GCOM1_uc002aem.2_Intron|GCOM1_uc002aeq.2_Intron|GCOM1_uc002aen.2_Intron|GCOM1_uc010bfy.2_Intron|GCOM1_uc002aeo.2_Intron|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_Intron|GRINL1A_uc002aes.2_Intron|GRINL1A_uc002aev.1_3'UTR|GRINL1A_uc010ugu.1_RNA|GRINL1A_uc002aeu.3_Intron	NM_015532	NP_056347	P0CAP1	GCOM1_HUMAN	glutamate receptor, ionotropic, N-methyl	380	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band					0				all cancers(107;0.0697)|GBM - Glioblastoma multiforme(80;0.12)		TTAGACTGTAAGCTAAGGCAA	0.398			NA											7	51					0	0	0.001984	0	0
IGDCC3	9543	broad.mit.edu	37	15	65622728	65622728	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:65622728A>T	uc002aos.2	-	11	2013	c.1761T>A	c.(1759-1761)ACT>ACA	p.T587T	IGDCC3_uc002aor.1_5'Flank	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	587	Extracellular (Potential).|Fibronectin type-III 2.									ovary(3)	3						CATACACTGCAGTGGGGTCTG	0.602			NA											4	53					0	0	0.001168	0	0
IGDCC4	57722	broad.mit.edu	37	15	65677373	65677373	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:65677373C>A	uc002aou.1	-	19	3471	c.3261G>T	c.(3259-3261)CCG>CCT	p.P1087P	IGDCC4_uc002aot.1_Silent_p.P675P	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1087	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGGTCAGAGCCGGCCGGGGGC	0.672			NA									OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	37					3.59834e-05	5.08422e-05	0.001168	1	0
IGDCC4	57722	broad.mit.edu	37	15	65702597	65702597	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:65702597C>A	uc002aou.1	-	3	692	c.482G>T	c.(481-483)CGC>CTC	p.R161L		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	161	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GCACTCAAAGCGAGCTGTCCC	0.582			NA											4	47					0.000602214	0.000754262	0.000602	1	0
SPESP1	246777	broad.mit.edu	37	15	69238614	69238614	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:69238614C>G	uc002arn.1	+	2	869	c.741C>G	c.(739-741)AAC>AAG	p.N247K	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	247					multicellular organismal development	acrosomal vesicle					0						ACACCAGCAACCCAGCATATA	0.363			NA											5	44					0	0	0.001168	0	0
ARIH1	25820	broad.mit.edu	37	15	72873191	72873191	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:72873191G>T	uc002aut.3	+	12	1649	c.1335G>T	c.(1333-1335)ATG>ATT	p.M445I		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	445	Potential.				ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0						TGGAGGAGATGCAGCAGCACA	0.478			NA											10	55					2.17888e-05	3.14511e-05	0.006214	1	0
PML	5371	broad.mit.edu	37	15	74337270	74337270	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:74337270C>T	uc002awv.2	+	9	2710	c.2570C>T	c.(2569-2571)CCG>CTG	p.P857L	PML_uc002awu.2_Missense_Mutation_p.P809L|PML_uc010ule.1_Missense_Mutation_p.P418L	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	857					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						TTGGAGGGTCCGGCGCTGGCA	0.647			NA	T	RARA|PAX5	APL|ALL								10	60					0	0	0.001368	0	0
SIN3A	25942	broad.mit.edu	37	15	75684637	75684637	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:75684637T>C	uc002bai.2	-	15	3056	c.2797A>G	c.(2797-2799)ATA>GTA	p.I933V	SIN3A_uc002baj.2_Missense_Mutation_p.I933V|SIN3A_uc010uml.1_Missense_Mutation_p.I933V	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	933					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TCTCGCTTTATGCCCAGCACT	0.512			NA											21	107					0	0	0.00333	0	0
SNUPN	10073	broad.mit.edu	37	15	75890754	75890754	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:75890754T>A	uc002ban.2	-	9	1118	c.1028A>T	c.(1027-1029)AAG>ATG	p.K343M	SNUPN_uc002bao.2_Missense_Mutation_p.K343M|SNUPN_uc002bap.2_Missense_Mutation_p.K385M|SNUPN_uc002baq.2_Missense_Mutation_p.K343M|SNUPN_uc002bar.2_Missense_Mutation_p.K343M|SNUPN_uc002bas.2_Missense_Mutation_p.K343M	NM_005701	NP_005692	O95149	SPN1_HUMAN	snurportin 1	343					ncRNA metabolic process|protein import into nucleus|spliceosomal snRNP assembly	cytosol|nuclear pore	protein transporter activity|RNA cap binding			pancreas(1)	1						ACCCTTCAACTTGGGAGTAGA	0.517			NA											8	42					0	0	0.004482	0	0
CSPG4	1464	broad.mit.edu	37	15	75981912	75981912	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:75981912G>T	uc002baw.2	-	3	1587	c.1494C>A	c.(1492-1494)GAC>GAA	p.D498E		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	498	Extracellular (Potential).|CSPG 1.|Globular or compact configuration stabilized by disulfide bonds.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						GGTTCACCACGTCCAGGAGGG	0.647			NA											6	63					0.00116845	0.00142726	0.001168	1	0
FSD2	123722	broad.mit.edu	37	15	83455968	83455968	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:83455968C>A	uc002bjd.2	-	2	342	c.175G>T	c.(175-177)GGG>TGG	p.G59W	FSD2_uc010uol.1_Missense_Mutation_p.G59W|FSD2_uc010uom.1_Missense_Mutation_p.G59W	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	59										central_nervous_system(1)	1						TTACCATCCCCTGCTCCTCTT	0.448			NA											5	72					0.00116845	0.00142726	0.001168	1	0
BNC1	646	broad.mit.edu	37	15	83931874	83931874	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:83931874G>C	uc002bjt.1	-	4	2217	c.2129C>G	c.(2128-2130)GCA>GGA	p.A710G	BNC1_uc010uos.1_Missense_Mutation_p.A698G	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	710					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CCTTGCTAATGCATGCTGACC	0.448			NA											6	65					0	0	0.001168	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611675	84611675	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:84611675G>C	uc002bjz.3	+	19	2555	c.2331G>C	c.(2329-2331)GGG>GGC	p.G777G	ADAMTSL3_uc010bmt.1_Silent_p.G777G|ADAMTSL3_uc010bmu.1_Silent_p.G777G	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	777	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTTGTGGCGGGGGAACTCAGA	0.537			NA											5	21					0	0	0.001168	0	0
ACAN	176	broad.mit.edu	37	15	89400832	89400832	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:89400832C>A	uc010upo.1	+	12	5390	c.5016C>A	c.(5014-5016)GCC>GCA	p.A1672A	ACAN_uc010upp.1_Silent_p.A1672A|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1672					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGGTCACAGCCTCCACTGCAA	0.537			NA											6	94					0.00198382	0.00238984	0.001984	1	0
BLM	641	broad.mit.edu	37	15	91303889	91303889	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:91303889G>A	uc002bpr.2	+	7	1383	c.1286G>A	c.(1285-1287)AGA>AAA	p.R429K	BLM_uc010uqh.1_Missense_Mutation_p.R429K|BLM_uc010uqi.1_Missense_Mutation_p.R54K|BLM_uc010bnx.2_Missense_Mutation_p.R429K|BLM_uc002bps.1_5'UTR	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	429					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TCATTGTGGAGATACAGGCCT	0.393			NA	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				8	124					0	0	0.004482	0	0
SV2B	9899	broad.mit.edu	37	15	91803568	91803568	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr15:91803568G>A	uc002bqv.2	+	5	1328	c.937G>A	c.(937-939)GCC>ACC	p.A313T	SV2B_uc002bqt.2_Missense_Mutation_p.A313T|SV2B_uc010uqv.1_Missense_Mutation_p.A162T|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	313	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			ACATGATGAAGCCTGGATGAT	0.463			NA											10	62					0	0	0.001368	0	0
CPPED1	55313	broad.mit.edu	37	16	12758931	12758931	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:12758931C>G	uc002dca.3	-	4	868	c.757G>C	c.(757-759)GGG>CGG	p.G253R	CPPED1_uc002dcb.3_Missense_Mutation_p.G111R|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	253							hydrolase activity|metal ion binding				0						TAGGTACCCCCGGCATTCCTG	0.582			NA											5	34					0	0	0.000602	0	0
XYLT1	64131	broad.mit.edu	37	16	17202756	17202756	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:17202756C>A	uc002dfa.2	-	12	2761	c.2676G>T	c.(2674-2676)CGG>CGT	p.R892R		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	892	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CTGCGTTCCTCCGTGCCTGTT	0.652			NA											7	59					5.18039e-06	7.8153e-06	0.00308	1	0
ARL6IP1	23204	broad.mit.edu	37	16	18810034	18810034	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:18810034A>G	uc002dfl.1	-	2	228	c.159T>C	c.(157-159)TCT>TCC	p.S53S	ARL6IP1_uc010van.1_Silent_p.S24S|ARL6IP1_uc010bvz.1_RNA	NM_015161	NP_055976	Q15041	AR6P1_HUMAN	ADP-ribosylation factor-like 6 interacting	53	Helical; (Potential).					integral to membrane	protein binding				0						GAAACACCAAAGAAACCACAC	0.423			NA											7	85					0	0	0.001984	0	0
UMOD	7369	broad.mit.edu	37	16	20357478	20357478	+	Silent	SNP	G	G	T	rs143764582		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:20357478G>T	uc002dgz.2	-	5	1281	c.1152C>A	c.(1150-1152)GCC>GCA	p.A384A	UMOD_uc002dha.2_Silent_p.A384A|UMOD_uc002dhb.2_Silent_p.A417A	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	384	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						GGCCATCCCGGGCTGGGGTCA	0.473			NA											3	26					0.004672	0.00544907	0.004672	1	0
DCUN1D3	123879	broad.mit.edu	37	16	20873563	20873563	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:20873563C>G	uc002dhz.2	-	2	439	c.298G>C	c.(298-300)GAT>CAT	p.D100H	ERI2_uc002dht.3_Intron	NM_173475	NP_775746	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain	100	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				ovary(2)	2				GBM - Glioblastoma multiforme(48;0.249)		TCCCGCTCATCCTTGTAGCGC	0.532			NA											15	132					0	0	0.004007	0	0
ANKS4B	257629	broad.mit.edu	37	16	21245167	21245167	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:21245167C>G	uc010bwp.1	+	1	152	c.109C>G	c.(109-111)CTC>GTC	p.L37V		NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	37	ANK 1.									ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		GACTCCTACTCTCTTGGCAGC	0.463			NA											3	68					0	0	0.000248	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826315	22826315	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:22826315G>C	uc002dli.2	+	1	456	c.384G>C	c.(382-384)CGG>CGC	p.R128R	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	128	PAPS and substrate (By similarity).|Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		GGGGCACCCGGGCCGTGCTGG	0.627			NA											5	21					0	0	0.000602	0	0
USP31	57478	broad.mit.edu	37	16	23080339	23080339	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:23080339G>C	uc002dll.2	-	16	3087	c.3087C>G	c.(3085-3087)TCC>TCG	p.S1029S	USP31_uc002dlk.2_Silent_p.S301S|USP31_uc010vca.1_Silent_p.S332S|USP31_uc010bxm.2_Silent_p.S317S	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1029	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		AAGTGCCTTTGGAACTGGGGG	0.542			NA											12	66					0	0	0.001855	0	0
USP31	57478	broad.mit.edu	37	16	23085137	23085137	+	Silent	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:23085137C>G	uc002dll.2	-	14	2241	c.2241G>C	c.(2239-2241)CTG>CTC	p.L747L	USP31_uc002dlk.2_5'Flank|USP31_uc010vca.1_Silent_p.L50L|USP31_uc010bxm.2_Silent_p.L35L	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	747					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CATCTTCTGACAGCTGCTGCA	0.587			NA											4	27					0	0	0.000248	0	0
COG7	91949	broad.mit.edu	37	16	23436189	23436189	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:23436189C>A	uc002dlo.2	-	7	1078	c.890G>T	c.(889-891)TGC>TTC	p.C297F		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	297					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		GTTGCTGAGGCAGGAGGGCAG	0.637			NA											7	54					0.000157383	0.000211083	0.00308	1	0
PALB2	79728	broad.mit.edu	37	16	23646849	23646849	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:23646849T>G	uc002dlx.1	-	4	1218	c.1018A>C	c.(1018-1020)AAT>CAT	p.N340H		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	340					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		TGGTTTTCATTTGCTGGTAAG	0.338			NA	F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				12	97					0	0	0.000978	0	0
SLC5A11	115584	broad.mit.edu	37	16	24888606	24888606	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:24888606A>T	uc002dmu.2	+	7	737	c.505A>T	c.(505-507)ATC>TTC	p.I169F	SLC5A11_uc002dms.2_Missense_Mutation_p.I105F|SLC5A11_uc010vcd.1_Missense_Mutation_p.I134F|SLC5A11_uc002dmt.2_Missense_Mutation_p.I105F|SLC5A11_uc010vce.1_Missense_Mutation_p.I99F|SLC5A11_uc010bxt.2_Missense_Mutation_p.I105F	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	169	Extracellular (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		TGCCATCTTCATCCAGCAGTC	0.408			NA											18	299					0	0	0.008871	0	0
ITGAL	3683	broad.mit.edu	37	16	30532894	30532894	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:30532894G>A	uc002dyi.3	+	31	3597	c.3421G>A	c.(3421-3423)GAG>AAG	p.E1141K	ITGAL_uc002dyj.3_Missense_Mutation_p.E1057K|ITGAL_uc010vev.1_Missense_Mutation_p.E375K	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	1141	Cytoplasmic (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AGAAGACTCTGAGCAGCTGGC	0.552	NSCLC(110;1462 1641 3311 33990 49495)		NA											5	55					0	0	0.001168	0	0
SRCAP	10847	broad.mit.edu	37	16	30750714	30750714	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:30750714G>T	uc002dze.1	+	34	9738	c.9353G>T	c.(9352-9354)CGC>CTC	p.R3118L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R2913L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	3118					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCAAAACTGCGCTCGACCCGG	0.597			NA											4	40					2.56e-06	3.89312e-06	0.000248	1	0
ITGAM	3684	broad.mit.edu	37	16	31308933	31308933	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:31308933G>T	uc002ebq.2	+	13	1553	c.1455G>T	c.(1453-1455)CAG>CAT	p.Q485H	ITGAM_uc002ebr.2_Missense_Mutation_p.Q485H|ITGAM_uc010cam.1_Missense_Mutation_p.D89Y|ITGAM_uc010can.2_5'UTR	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	485	FG-GAP 5.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						ACTACGAGCAGACCCGAGGGG	0.701			NA											14	78					1.3612e-06	2.12408e-06	0.003163	1	0
ITGAD	3681	broad.mit.edu	37	16	31409184	31409185	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:31409184_31409185GG>TT	uc002ebv.1	+	5	430_431	c.381_382GG>TT	c.(379-384)CTGGGC>CTTTGC	p.G128C	ITGAD_uc010vfl.1_Missense_Mutation_p.G128C|ITGAD_uc010cap.1_Missense_Mutation_p.G128C|ITGAD_uc002ebw.1_5'UTR	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	128	FG-GAP 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GCCTCCTGCTGGGCTCGCGCTG	0.644			NA											4	22					0	0	0.004672	0	0
NETO2	81831	broad.mit.edu	37	16	47162481	47162481	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:47162481G>C	uc002eer.1	-	4	621	c.236C>G	c.(235-237)GCT>GGT	p.A79G	NETO2_uc010vgf.1_5'UTR|NETO2_uc002ees.1_Missense_Mutation_p.A79G	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	79	Extracellular (Potential).|CUB 1.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TTGACGTGGAGCAGCTAGAAA	0.353			NA								HNSCC(25;0.065)			17	87					0	0	0.00499	0	0
N4BP1	9683	broad.mit.edu	37	16	48585318	48585318	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:48585318C>A	uc002efp.2	-	4	2333	c.2096G>T	c.(2095-2097)AGA>ATA	p.R699I		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	699					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				AGAAGCAATTCTTTCTCCAAA	0.483			NA											7	94					0.000157383	0.000211083	0.00308	1	0
CETP	1071	broad.mit.edu	37	16	57015098	57015098	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:57015098A>T	uc002eki.2	+	12	1232	c.1175A>T	c.(1174-1176)TAT>TTT	p.Y392F	CETP_uc002ekj.2_Missense_Mutation_p.Y332F	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	392				Y->S: Not secreted.	cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						CAGGCCTCCTATTCTAAGAAA	0.542			NA											8	87					0	0	0.006214	0	0
GOT2	2806	broad.mit.edu	37	16	58756164	58756164	+	Missense_Mutation	SNP	C	C	A	rs137905758	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:58756164C>A	uc002eof.1	-	3	379	c.265G>T	c.(265-267)GCA>TCA	p.A89S	GOT2_uc010vim.1_Intron	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	89					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAATTTTTTGCGGCAATCTGG	0.408			NA											12	46					7.03913e-09	1.21342e-08	0.001368	1	0
CDH11	1009	broad.mit.edu	37	16	64981755	64981755	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:64981755G>C	uc002eoi.2	-	13	2576	c.2142C>G	c.(2140-2142)AGC>AGG	p.S714R	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Missense_Mutation_p.S588R	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	714	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CGACATCCACGCTGTTGGGCG	0.502			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			5	80					0	0	0.000602	0	0
ZFP90	146198	broad.mit.edu	37	16	68598507	68598507	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:68598507A>G	uc010cff.2	+	5	2109	c.1817A>G	c.(1816-1818)GAA>GGA	p.E606G	ZFP90_uc002ewb.2_3'UTR|ZFP90_uc002ewc.2_3'UTR|ZFP90_uc002ewd.2_Missense_Mutation_p.E606G|ZFP90_uc002ewe.2_Missense_Mutation_p.E606G	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	606					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CATACTGGAGAAAAACCCTAT	0.403			NA											8	69					0	0	0.00308	0	0
KIAA0174	9798	broad.mit.edu	37	16	71954700	71954700	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:71954700A>T	uc002fbj.1	+	7	738	c.455A>T	c.(454-456)AAC>ATC	p.N152I	KIAA0174_uc010cgh.1_Missense_Mutation_p.N152I|KIAA0174_uc002fbk.1_Missense_Mutation_p.N139I|KIAA0174_uc002fbm.1_Missense_Mutation_p.N139I|KIAA0174_uc002fbl.1_Missense_Mutation_p.N139I|KIAA0174_uc002fbn.1_5'UTR|KIAA0174_uc010cgi.1_Intron|KIAA0174_uc010cgj.1_Missense_Mutation_p.N71I|KIAA0174_uc010vml.1_5'Flank|KIAA0174_uc010vmk.1_Intron			P53990	IST1_HUMAN	SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;	139	Interaction with VPS37B.|Interaction with CHMP1A and CHMP1B.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1						TGTAGGACCAACCAGATTGGA	0.418			NA											4	34					0	0	0.000248	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77396106	77396106	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:77396106C>A	uc002ffc.3	-	7	1531	c.1112G>T	c.(1111-1113)TGG>TTG	p.W371L	ADAMTS18_uc010chc.1_5'UTR|ADAMTS18_uc002ffe.1_Missense_Mutation_p.W67L|ADAMTS18_uc010vni.1_Intron	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	371	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGCAGACTGCCATTGACAAAA	0.403			NA											7	32					8.12818e-05	0.000110582	0.001984	1	0
PKD1L2	114780	broad.mit.edu	37	16	81181756	81181756	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:81181756C>A	uc002fgh.1	-	29	4960	c.4960G>T	c.(4960-4962)GCA>TCA	p.A1654S	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1654	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTGGTCACTGCCTCAGGTGTC	0.652			NA											3	11					0.004672	0.00544907	0.004672	1	0
CRISPLD2	83716	broad.mit.edu	37	16	84907567	84907567	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:84907567A>T	uc010voh.1	+	11	1381	c.1154A>T	c.(1153-1155)AAA>ATA	p.K385I	CRISPLD2_uc010vog.1_Intron|CRISPLD2_uc002fio.2_Missense_Mutation_p.K384I|CRISPLD2_uc002fin.3_Missense_Mutation_p.K385I	NM_031476	NP_113664	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain	385	LCCL 2.					extracellular region|transport vesicle					0						TCAAAAGTGAAAGGTAAGCTA	0.343			NA											20	94					0	0	0.001882	0	0
ZNF778	197320	broad.mit.edu	37	16	89294046	89294046	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:89294046G>T	uc002fmv.2	+	6	1605	c.1266G>T	c.(1264-1266)ACG>ACT	p.T422T	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Silent_p.T380T|ZNF778_uc010vpg.1_Silent_p.T185T	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	422	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		AGCCATACACGTGTAAGGACT	0.498			NA											3	33					0.004672	0.00544907	0.004672	1	0
ATP2A3	489	broad.mit.edu	37	17	3839652	3839652	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:3839652C>A	uc002fxb.1	-	16	2584	c.2433G>T	c.(2431-2433)CCG>CCT	p.P811P	ATP2A3_uc002fwx.1_Silent_p.P811P|ATP2A3_uc002fwy.1_Silent_p.P811P|ATP2A3_uc002fwz.1_Silent_p.P811P|ATP2A3_uc002fxa.1_Silent_p.P811P|ATP2A3_uc002fxc.1_Silent_p.P811P|ATP2A3_uc002fxd.1_Silent_p.P811P	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	811	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCAGGTCTGGCGGGTTGAAGC	0.637	GBM(32;29 774 15719 37967)		NA											5	54					5.9392e-07	9.42309e-07	0.001168	1	0
ZZEF1	23140	broad.mit.edu	37	17	3954138	3954138	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:3954138T>G	uc002fxe.2	-	36	5864	c.5800A>C	c.(5800-5802)ACC>CCC	p.T1934P	ZZEF1_uc002fxh.2_Missense_Mutation_p.T248P|ZZEF1_uc002fxi.2_Missense_Mutation_p.T169P|ZZEF1_uc002fxj.1_Missense_Mutation_p.T547P	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1934							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTCCGCAGGGTGGTGGCACTG	0.607			NA											10	36					0	0	0.001368	0	0
ASGR2	433	broad.mit.edu	37	17	7004962	7004962	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:7004962C>A	uc002gep.3	-	9	1133	c.868G>T	c.(868-870)GAC>TAC	p.D290Y	ASGR2_uc010vtk.1_Missense_Mutation_p.D127Y|ASGR2_uc002gem.1_Missense_Mutation_p.D229Y|ASGR2_uc002gen.1_Missense_Mutation_p.D271Y|ASGR2_uc002geo.1_Missense_Mutation_p.D285Y|ASGR2_uc002ger.3_Missense_Mutation_p.D290Y|ASGR2_uc002geq.3_Missense_Mutation_p.D266Y	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	290	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	AGGCAGAAGTCATCGTTCCAG	0.597			NA											9	37					1.12685e-05	1.66247e-05	0.004482	1	0
CHRNB1	1140	broad.mit.edu	37	17	7350393	7350393	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:7350393A>G	uc002ghb.2	+	5	426	c.385A>G	c.(385-387)ATT>GTT	p.I129V	CHRNB1_uc010vty.1_Missense_Mutation_p.I57V|CHRNB1_uc010vtz.1_5'UTR	NM_000747	NP_000738	P11230	ACHB_HUMAN	nicotinic acetylcholine receptor beta 1 subunit	129	Extracellular (Potential).				behavioral response to nicotine|muscle contraction|muscle fiber development|neuromuscular synaptic transmission|postsynaptic membrane organization|regulation of membrane potential|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine binding|receptor activity			ovary(2)	2		Prostate(122;0.157)				GGCTCTGGACATTAGCGTCGT	0.463			NA											5	46					0	0	0.001168	0	0
TP53	7157	broad.mit.edu	37	17	7577046	7577046	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:7577046C>A	uc002gim.2	-	8	1086	c.892G>T	c.(892-894)GAG>TAG	p.E298*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E298*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E166*|TP53_uc010cng.1_Nonsense_Mutation_p.E166*|TP53_uc002gii.1_Nonsense_Mutation_p.E166*|TP53_uc010cnh.1_Nonsense_Mutation_p.E298*|TP53_uc010cni.1_Nonsense_Mutation_p.E298*|TP53_uc002gij.2_Nonsense_Mutation_p.E298*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	298	Interaction with HIPK1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(35)|p.0?(7)|p.E298K(2)|p.?(2)|p.E298V(2)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298A(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298fs*47(1)|p.E298E(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	39					0.00307968	0.00367105	0.00308	1	0
PER1	5187	broad.mit.edu	37	17	8051528	8051528	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:8051528G>T	uc002gkd.2	-	9	1336	c.1098C>A	c.(1096-1098)CCC>CCA	p.P366P	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.P350P	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	366	PAS 2.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						AGAGGCAGCTGGGTGTGTGCC	0.597			NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					7	42					0.00448238	0.00529312	0.004482	1	0
MYH2	4620	broad.mit.edu	37	17	10433048	10433048	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:10433048G>T	uc010coi.2	-	24	3078	c.2950C>A	c.(2950-2952)CTC>ATC	p.L984I	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.L984I|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	984	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCTTCTGTGAGGTTTTTCACC	0.468			NA											21	213					1.96292e-10	3.53388e-10	0.001523	1	0
DNAH9	1770	broad.mit.edu	37	17	11593206	11593206	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:11593206T>A	uc002gne.2	+	20	4135	c.4067T>A	c.(4066-4068)TTC>TAC	p.F1356Y	DNAH9_uc010coo.2_Missense_Mutation_p.F650Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1356	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGGGATGCATTCACAGGCCTG	0.587			NA											9	11					0	0	0.004482	0	0
DNAH9	1770	broad.mit.edu	37	17	11593507	11593507	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:11593507G>A	uc002gne.2	+	20	4436	c.4368G>A	c.(4366-4368)CGG>CGA	p.R1456R	DNAH9_uc010coo.2_Silent_p.R750R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1456	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCCACCCACGGACCAATGTCC	0.493			NA											19	40					0	0	0.001882	0	0
SLC5A10	125206	broad.mit.edu	37	17	18922899	18922899	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:18922899G>C	uc002guu.1	+	12	1446	c.1405G>C	c.(1405-1407)GAG>CAG	p.E469Q	SLC5A10_uc002gur.1_Missense_Mutation_p.E439Q|SLC5A10_uc002gut.1_Missense_Mutation_p.E485Q|SLC5A10_uc002guv.1_Missense_Mutation_p.E442Q|SLC5A10_uc010vyl.1_Missense_Mutation_p.E433Q|SLC5A10_uc002gux.1_RNA	NM_001042450	NP_001035915	A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/glucose	469	Cytoplasmic (Potential).				sodium ion transport|transmembrane transport	integral to membrane	transporter activity			ovary(1)	1						ACGTGCCAACGAGCAGGTGGG	0.642			NA											8	14					0	0	0.008291	0	0
NUFIP2	57532	broad.mit.edu	37	17	27613955	27613955	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:27613955C>G	uc002hdy.3	-	2	1146	c.1057G>C	c.(1057-1059)GTT>CTT	p.V353L	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	353						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			ATTTTAGGAACTATTTTAGCA	0.403			NA											17	87					0	0	0.006122	0	0
TMEM132E	124842	broad.mit.edu	37	17	32959728	32959728	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:32959728C>T	uc002hif.2	+	7	1546	c.1218C>T	c.(1216-1218)TCC>TCT	p.S406S		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	406	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCCAGGTATCCAGCAGCTGTG	0.567			NA											8	40					0	0	0.00308	0	0
FBXL20	84961	broad.mit.edu	37	17	37437684	37437684	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:37437684T>A	uc010wed.1	-	9	875	c.654A>T	c.(652-654)GCA>GCT	p.A218A	FBXL20_uc002hrt.2_Silent_p.A218A|FBXL20_uc010cvu.2_Silent_p.A186A	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	218	LRR 6.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			CAGGGCAGTGTGCACCTATGT	0.328			NA											4	48					0	0	0.000248	0	0
GRB7	2886	broad.mit.edu	37	17	37900435	37900435	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:37900435A>G	uc002hsr.2	+	7	1026	c.776A>G	c.(775-777)TAT>TGT	p.Y259C	GRB7_uc002hss.2_Missense_Mutation_p.Y259C|GRB7_uc010cwc.2_Missense_Mutation_p.Y259C|GRB7_uc002hst.2_Missense_Mutation_p.Y259C	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	259	PH.			Y->F: Global loss of tyrosine phosphorylation. Abolishes interaction with FHL2 and HAX1.	blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCTGGCCTCTATTACTCCACC	0.562			NA											6	216					0	0	0.001168	0	0
MED24	9862	broad.mit.edu	37	17	38183255	38183255	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:38183255C>G	uc002htt.2	-	17	1876	c.1563G>C	c.(1561-1563)GAG>GAC	p.E521D	MED24_uc010wes.1_Missense_Mutation_p.E381D|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Missense_Mutation_p.E546D|MED24_uc002htu.2_Missense_Mutation_p.E508D|MED24_uc010cwn.2_Missense_Mutation_p.E508D|MED24_uc010weu.1_Missense_Mutation_p.E431D|MED24_uc010wev.1_Missense_Mutation_p.E471D|MED24_uc010wew.1_Missense_Mutation_p.E462D|MED24_uc010wex.1_Missense_Mutation_p.E226D|SNORD124_uc010wey.1_5'Flank	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	521					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					AGAAGGGCACCTCAGCTCCTG	0.667			NA									OREG0024386	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	16					0	0	0.004482	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254037	39254037	+	Silent	SNP	G	G	A	rs141299737	by1000genomes	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:39254037G>A	uc010wfo.1	-	1	339	c.300C>T	c.(298-300)TGC>TGT	p.C100C		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	100	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].|16.					keratin filament					0						agctggggcggcagcagctgg	0.254			NA											3	23					0	0	0.001984	0	0
GAST	2520	broad.mit.edu	37	17	39871799	39871799	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:39871799G>T	uc002hxl.2	+	2	143	c.111G>T	c.(109-111)GGG>GGT	p.G37G	JUP_uc010wfs.1_Intron	NM_000805	NP_000796	P01350	GAST_HUMAN	gastrin preproprotein	37						extracellular region	hormone activity				0		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TAGGTACAGGGGCCAACAGGG	0.627			NA											24	98					1.22574e-08	2.10656e-08	0.002299	1	0
NT5C3L	115024	broad.mit.edu	37	17	39985171	39985171	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:39985171G>A	uc002hyc.3	-	7	549	c.540C>T	c.(538-540)TAC>TAT	p.Y180Y	NT5C3L_uc002hxx.3_Silent_p.Y45Y|NT5C3L_uc010wfu.1_Silent_p.Y45Y|NT5C3L_uc002hyb.3_Silent_p.Y103Y|NT5C3L_uc002hyd.3_Silent_p.Y103Y|NT5C3L_uc002hxy.3_Silent_p.Y138Y|NT5C3L_uc002hxz.3_Silent_p.Y103Y|NT5C3L_uc002hya.3_Intron	NM_052935	NP_443167	C9JKC4	C9JKC4_HUMAN	5'-nucleotidase, cytosolic III-like	146						cytoplasm	5'-nucleotidase activity|magnesium ion binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.15)		TGTTGTTATGGTAGAGTGTGT	0.438			NA											12	63					0	0	0.001368	0	0
ASB16	92591	broad.mit.edu	37	17	42248402	42248402	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:42248402C>A	uc002ifl.1	+	1	329	c.245C>A	c.(244-246)GCC>GAC	p.A82D	ASB16_uc002ifm.1_RNA	NM_080863	NP_543139	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box-containing protein	82	ANK 1.				intracellular signal transduction		protein binding			kidney(2)	2		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GATGAAGAGGCCGCCAACATG	0.517			NA											7	20					8.12818e-05	0.000110582	0.001984	1	0
ITGA2B	3674	broad.mit.edu	37	17	42457994	42457994	+	Nonsense_Mutation	SNP	G	G	T	rs78218617		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:42457994G>T	uc002igt.1	-	14	1445	c.1413C>A	c.(1411-1413)TAC>TAA	p.Y471*	ITGA2B_uc002igu.1_5'UTR	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	471	Extracellular (Potential).|FG-GAP 7.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGTTGGCCCCGTAAGCTCCCA	0.602			NA											3	43					0.00024832	0.000325365	0.000248	1	0
GPATCH8	23131	broad.mit.edu	37	17	42477491	42477491	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:42477491C>A	uc002igw.1	-	8	2018	c.1954G>T	c.(1954-1956)GGG>TGG	p.G652W	GPATCH8_uc002igv.1_Missense_Mutation_p.G574W|GPATCH8_uc010wiz.1_Missense_Mutation_p.G574W	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	652						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GTCTCAGACCCATGGCTACCC	0.532			NA									OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	64					0.00448238	0.00529312	0.004482	1	0
WNT9B	7484	broad.mit.edu	37	17	44953934	44953934	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:44953934G>T	uc002ikw.1	+	4	961	c.924G>T	c.(922-924)GAG>GAT	p.E308D	WNT9B_uc002ikx.1_Intron	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	308					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GCTCCCGGGAGGCCAGCTGCA	0.667			NA											5	49					2.7689e-08	4.68773e-08	0.001984	1	0
MYL4	4635	broad.mit.edu	37	17	45299181	45299181	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:45299181G>T	uc002ilg.2	+	5	575	c.447G>T	c.(445-447)ACG>ACT	p.T149T	MYL4_uc002ilh.2_Silent_p.T149T	NM_001002841	NP_001002841	P12829	MYL4_HUMAN	atrial/embryonic alkali myosin light chain	149	EF-hand 2.				cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			ovary(2)	2						GCAATGGCACGGTCATGGGTG	0.597			NA											9	29					0.000442599	0.000568128	0.006214	1	0
TMEM100	55273	broad.mit.edu	37	17	53798315	53798315	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:53798315C>A	uc002iuj.3	-	2	428	c.117G>T	c.(115-117)GAG>GAT	p.E39D	TMEM100_uc002iuk.3_Missense_Mutation_p.E39D	NM_018286	NP_060756	Q9NV29	TM100_HUMAN	transmembrane protein 100	39						integral to membrane					0						TCAACTGAATCTCACTGACCA	0.572			NA											15	69					1.02788e-11	1.90175e-11	0.00499	1	0
TRIM25	7706	broad.mit.edu	37	17	54969240	54969240	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:54969240T>G	uc002iut.2	-	9	1774	c.1714A>C	c.(1714-1716)ACC>CCC	p.T572P	TRIM25_uc010dcj.2_Missense_Mutation_p.T364P	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	572	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					GTGGCCTTGGTGGAGGGCAGG	0.572			NA											5	44					0	0	0.000602	0	0
OR4D2	124538	broad.mit.edu	37	17	56247135	56247135	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:56247135T>C	uc010wnp.1	+	1	119	c.119T>C	c.(118-120)ATG>ACG	p.M40T		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						ACCACTGTTATGGGAAACATC	0.498			NA											22	98					0	0	0.001882	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386312	56386312	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:56386312C>A	uc002ivx.3	-	22	5192	c.4321G>T	c.(4321-4323)GGA>TGA	p.G1441*	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Nonsense_Mutation_p.G1381*|BZRAP1_uc010wnt.1_Nonsense_Mutation_p.G1441*	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1441						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCAGTCGTCCAGAGGCCTGG	0.692			NA											7	69					2.0095e-06	3.08069e-06	0.001984	1	0
BZRAP1	9256	broad.mit.edu	37	17	56386537	56386537	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:56386537C>A	uc002ivx.3	-	22	4967	c.4096G>T	c.(4096-4098)GGG>TGG	p.G1366W	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.G1306W|BZRAP1_uc010wnt.1_Missense_Mutation_p.G1366W	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1366						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAGCCCAGCCCCAGCAATGCA	0.502			NA											4	69					0.000602214	0.000754262	0.000602	1	0
CLTC	1213	broad.mit.edu	37	17	57725719	57725719	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:57725719C>A	uc002ixq.1	+	4	1081	c.638C>A	c.(637-639)TCA>TAA	p.S213*	CLTC_uc002ixp.2_Nonsense_Mutation_p.S213*|CLTC_uc002ixr.1_Nonsense_Mutation_p.S217*	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	213	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GCAGAAGAATCAACGTTATTT	0.403			NA	T	ALK|TFE3	ALCL|renal 								16	87					5.03518e-11	9.25561e-11	0.007413	1	0
GH1	2688	broad.mit.edu	37	17	61995747	61995747	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:61995747G>T	uc002jdj.2	-	2	192	c.130C>A	c.(130-132)CAT>AAT	p.H44N	GH1_uc002jdi.2_Missense_Mutation_p.H44N|GH1_uc002jdk.2_Missense_Mutation_p.H44N|GH1_uc002jdl.2_Missense_Mutation_p.H44N|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Missense_Mutation_p.H44N	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	44		Zinc (By similarity).			glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						TGCAGACGATGGGCGCGGAGC	0.592			NA											14	165					7.93312e-07	1.24304e-06	0.00245	1	0
SCN4A	6329	broad.mit.edu	37	17	62020273	62020273	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:62020273C>T	uc002jds.1	-	23	4278	c.4201G>A	c.(4201-4203)GTG>ATG	p.V1401M		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1401	IV.|Helical; Name=S2 of repeat IV; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	ATCTTGAGCACGCACTCCCCT	0.542			NA											7	47					0	0	0.00308	0	0
SCN4A	6329	broad.mit.edu	37	17	62022924	62022924	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:62022924C>A	uc002jds.1	-	19	3593	c.3516G>T	c.(3514-3516)CTG>CTT	p.L1172L		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1172	III.|Helical; Name=S5 of repeat III; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TGCTGAAGATCAGCCAGAAGA	0.562			NA											27	162					3.73988e-18	7.32501e-18	0.00632	1	0
ABCA10	10349	broad.mit.edu	37	17	67161197	67161198	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:67161197_67161198CC>AT	uc010dfa.1	-	27	4068_4069	c.3189_3190GG>AT	c.(3187-3192)ATGGTA>ATATTA	p.1063_1064MV>IL	ABCA10_uc010wqs.1_Missense_Mutation_p.55_56MV>IL|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1063_1064	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TGAGTTGATACCATAATTGTGG	0.302			NA											5	25					0	0	0.004672	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128795	68128795	+	Silent	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:68128795T>G	uc002jin.2	+	5	1053	c.567T>G	c.(565-567)CTT>CTG	p.L189L	KCNJ16_uc002jio.2_Silent_p.L189L|KCNJ16_uc002jip.2_Silent_p.L189L|KCNJ16_uc002jiq.2_Silent_p.L221L	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	189	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					ACTTTGCACTTATAGGTATGA	0.463			NA											14	70					0	0	0.00245	0	0
GPR142	350383	broad.mit.edu	37	17	72368146	72368146	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:72368146C>A	uc010wqy.1	+	4	796	c.796C>A	c.(796-798)CAT>AAT	p.H266N	GPR142_uc010wqx.1_Missense_Mutation_p.H178N	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	266	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CCCCCTGCACCATCGGGCCGC	0.657			NA											3	27					0.004672	0.00544907	0.004672	1	0
ZACN	353174	broad.mit.edu	37	17	74077485	74077485	+	Splice_Site	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:74077485T>A	uc002jqn.2	+	6	752	c.669_splice	c.e6+2	p.T223_splice	ZACN_uc002jqo.2_Splice_Site|ZACN_uc010dgu.2_Splice_Site|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqs.2_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel						response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						CAGGTGACGGTGAGTCAAGTC	0.622			NA											6	97					0	0	0.001984	0	0
RNF157	114804	broad.mit.edu	37	17	74157643	74157643	+	Silent	SNP	G	G	T	rs139660847		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:74157643G>T	uc002jqz.2	-	11	1107	c.1038C>A	c.(1036-1038)TCC>TCA	p.S346S	RNF157_uc002jra.2_Silent_p.S346S	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	346							zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			CAGATGTCTGGGATGAGATGA	0.498	GBM(186;507 2120 27388 27773 52994)		NA											5	52					1.23904e-05	1.80687e-05	0.000602	1	0
QRICH2	84074	broad.mit.edu	37	17	74288492	74288492	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:74288492G>T	uc002jrd.1	-	4	1998	c.1818C>A	c.(1816-1818)GTC>GTA	p.V606V	QRICH2_uc010wsz.1_Silent_p.V532V|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	606	Gln-rich.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CTCCAGGTTGGACCAAACCAT	0.378			NA											7	38					0.00307968	0.00367105	0.00308	1	0
C1QTNF1	114897	broad.mit.edu	37	17	77043860	77043860	+	Missense_Mutation	SNP	A	A	G	rs149440649	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:77043860A>G	uc002jwp.2	+	4	876	c.536A>G	c.(535-537)AAC>AGC	p.N179S	C1QTNF1_uc002jwq.2_Missense_Mutation_p.N97S|C1QTNF1_uc002jwr.3_Missense_Mutation_p.N189S|C1QTNF1_uc002jws.2_Missense_Mutation_p.N179S|C1QTNF1_uc002jwt.2_Missense_Mutation_p.N277S	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	179	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GACCACTTCAACATGTTCACC	0.557			NA											8	77					0	0	0.006214	0	0
MYOM1	8736	broad.mit.edu	37	18	3187492	3187492	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:3187492T>A	uc002klp.2	-	5	1249	c.915A>T	c.(913-915)GAA>GAT	p.E305D	MYOM1_uc002klq.2_Missense_Mutation_p.E305D	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	305	Ig-like C2-type 1.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TGACACGAGGTTCTGGCCAGC	0.433			NA											8	88					0	0	0.004482	0	0
DLGAP1	9229	broad.mit.edu	37	18	3534574	3534574	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:3534574T>A	uc002kmf.2	-	7	2164	c.2097A>T	c.(2095-2097)GCA>GCT	p.A699A	DLGAP1_uc010wyz.1_Silent_p.A699A|DLGAP1_uc002kme.1_Silent_p.A397A|DLGAP1_uc010dkn.2_Silent_p.A407A|DLGAP1_uc010wyw.1_Silent_p.A405A|DLGAP1_uc010wyx.1_Silent_p.A421A|DLGAP1_uc010wyy.1_Silent_p.A383A|DLGAP1_uc002kmg.2_Silent_p.A397A	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	699					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CGGCCTGTACTGCTGTCGTCA	0.423			NA											16	19					0	0	0.001882	0	0
DSC3	1825	broad.mit.edu	37	18	28586988	28586988	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:28586988A>T	uc002kwj.3	-	12	1928	c.1773T>A	c.(1771-1773)TAT>TAA	p.Y591*	DSC3_uc002kwi.3_Nonsense_Mutation_p.Y591*	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	591	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			AAATGTCGGTATACCCCATTT	0.393			NA											4	39					0	0	0.000248	0	0
DSG4	147409	broad.mit.edu	37	18	28983423	28983423	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:28983423C>A	uc002kwq.2	+	11	1597	c.1462C>A	c.(1462-1464)CCT>ACT	p.P488T	DSG4_uc002kwr.2_Missense_Mutation_p.P488T	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	488	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TATTGAGGTTCCTGATATCAA	0.383			NA											7	11					0.00307968	0.00367105	0.00308	1	0
DSG2	1829	broad.mit.edu	37	18	29125892	29125892	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:29125892A>G	uc002kwu.3	+	15	2731	c.2543A>G	c.(2542-2544)AAT>AGT	p.N848S	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	848	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			ATAGATATAAATAAGGAAATT	0.373			NA											5	76					0	0	0.001168	0	0
MEP1B	4225	broad.mit.edu	37	18	29790580	29790580	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:29790580T>C	uc002kxj.3	+	10	1083	c.1036T>C	c.(1036-1038)TAT>CAT	p.Y346H		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	346	Extracellular (Potential).|MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						ATTTTACTTATATAACAGTGG	0.423			NA											4	49					0	0	0.000602	0	0
DTNA	1837	broad.mit.edu	37	18	32431892	32431892	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:32431892G>T	uc010dmn.1	+	14	1452	c.1451G>T	c.(1450-1452)AGA>ATA	p.R484I	DTNA_uc010xbx.1_Missense_Mutation_p.R234I|DTNA_uc002kxv.3_Missense_Mutation_p.R427I|DTNA_uc002kxw.2_Missense_Mutation_p.R427I|DTNA_uc010dmj.2_Missense_Mutation_p.R424I|DTNA_uc002kxz.2_Missense_Mutation_p.R424I|DTNA_uc002kxy.2_Missense_Mutation_p.R424I|DTNA_uc010dml.2_Missense_Mutation_p.R424I|DTNA_uc002kyb.3_Missense_Mutation_p.R481I|DTNA_uc010dmm.2_Missense_Mutation_p.R484I|DTNA_uc010xby.1_Missense_Mutation_p.R174I|DTNA_uc010dmo.2_Missense_Mutation_p.R106I|DTNA_uc002kyd.3_Missense_Mutation_p.R106I|DTNA_uc010xbz.1_Missense_Mutation_p.R193I|DTNA_uc010xca.1_Missense_Mutation_p.R136I|DTNA_uc002kye.2_Missense_Mutation_p.R132I	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	484	Potential.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						AACAAGAACAGGTGAGACTTT	0.463			NA											6	18					3.59834e-05	5.08422e-05	0.001168	1	0
ZNF24	7572	broad.mit.edu	37	18	32920295	32920295	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:32920295T>C	uc002kyt.2	-	2	477	c.320A>G	c.(319-321)GAG>GGG	p.E107G	ZNF24_uc002kys.2_Missense_Mutation_p.E107G|ZNF24_uc002kyu.1_Missense_Mutation_p.E107G	NM_006965	NP_008896	P17028	ZNF24_HUMAN	zinc finger protein 24	107	SCAN box.				myelination|negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGTCTGTAGCTCTTTGGGTAG	0.517	Colon(42;769 913 8916 19469 46270)		NA											7	259					0	0	0.001984	0	0
SERPINB4	6318	broad.mit.edu	37	18	61328427	61328427	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:61328427G>T	uc002ljg.2	-	1	50	c.24C>A	c.(22-24)AAC>AAA	p.N8K	SERPINB3_uc002lji.2_Missense_Mutation_p.N8K|SERPINB3_uc010dqa.2_Missense_Mutation_p.N8K|SERPINB3_uc010dqb.2_Missense_Mutation_p.N8K|SERPINB3_uc010dqc.2_Missense_Mutation_p.N8K			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	8					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TGAACTTGGTGTTGGCTTCAC	0.413			NA											19	117					1.01871e-10	1.85161e-10	0.008871	1	0
ZNF407	55628	broad.mit.edu	37	18	72345910	72345911	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:72345910_72345911GG>TT	uc002llw.2	+	1	2992_2993	c.2935_2936GG>TT	c.(2935-2937)GGA>TTA	p.G979L	ZNF407_uc010xfc.1_Missense_Mutation_p.G979L|ZNF407_uc010dqu.1_Missense_Mutation_p.G979L|ZNF407_uc002llu.2_Missense_Mutation_p.G978L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	979					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TTCTCTAGATGGAGAAGTTAAC	0.446			NA											12	31					0	0	0.004672	0	0
ADNP2	22850	broad.mit.edu	37	18	77896229	77896229	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr18:77896229G>T	uc002lnw.2	+	4	3388	c.2933G>T	c.(2932-2934)AGA>ATA	p.R978I		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	978					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		TCTGTTAAGAGAAAGCTGCCT	0.547			NA											16	77					1.15088e-07	1.89204e-07	0.004007	1	0
ABCA7	10347	broad.mit.edu	37	19	1056364	1056364	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:1056364G>T	uc002lqw.3	+	33	4683	c.4452G>T	c.(4450-4452)GTG>GTT	p.V1484V	ABCA7_uc002lqy.2_5'Flank|ABCA7_uc010dsc.2_5'Flank	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1484	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTCCATGGTGGCCTTTGTCA	0.617			NA											8	33					3.09899e-07	4.96537e-07	0.004482	1	0
SEMA6B	10501	broad.mit.edu	37	19	4550174	4550174	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:4550174G>T	uc010duc.1	-	11	1270	c.1232C>A	c.(1231-1233)TCG>TAG	p.S411*	SEMA6B_uc010dud.2_Nonsense_Mutation_p.S411*|SEMA6B_uc010xih.1_Nonsense_Mutation_p.S411*	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	411	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGGCCCAGCGAGGGCACCGC	0.647			NA											10	29					1.58986e-06	2.46733e-06	0.008291	1	0
CLEC4M	10332	broad.mit.edu	37	19	7832409	7832409	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:7832409T>A	uc002mih.2	+	7	993	c.875T>A	c.(874-876)CTA>CAA	p.L292Q	CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.L248Q|CLEC4M_uc010dvt.2_Missense_Mutation_p.L269Q|CLEC4M_uc010dvs.2_Missense_Mutation_p.L291Q|CLEC4M_uc010xjx.1_Missense_Mutation_p.L264Q|CLEC4M_uc002mhz.2_Intron|CLEC4M_uc002mic.2_Intron|CLEC4M_uc002mia.2_Missense_Mutation_p.L179Q	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	315	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						CAGAACTTCCTACAGCTGCAG	0.542			NA											4	29					0	0	0.000248	0	0
LASS4	79603	broad.mit.edu	37	19	8321907	8321907	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:8321907G>A	uc002mjg.2	+	9	1007	c.687G>A	c.(685-687)CTG>CTA	p.L229L	LASS4_uc002mjh.2_Silent_p.L178L|LASS4_uc002mji.2_Silent_p.L65L|LASS4_uc010dvz.2_Silent_p.L229L	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	229	Helical; (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						CCAACCTGCTGCGCATTGGCT	0.587			NA											41	189					0	0	0.002852	0	0
MYO1F	4542	broad.mit.edu	37	19	8619559	8619559	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:8619559C>G	uc002mkg.2	-	3	324	c.210G>C	c.(208-210)GAG>GAC	p.E70D	MYO1F_uc002mkh.2_Missense_Mutation_p.E70D|MYO1F_uc010xkf.1_Missense_Mutation_p.E70D	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	70	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						AGAGGTCGATCTCACGGTCGG	0.627			NA											11	33					0	0	0.001855	0	0
OR7G1	125962	broad.mit.edu	37	19	9225719	9225719	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:9225719A>T	uc002mks.1	-	1	721	c.721T>A	c.(721-723)TGT>AGT	p.C241S		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	241	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TGACAGCCACAGGTGGAAAAC	0.433			NA											4	32					0	0	0.000248	0	0
ZNF846	162993	broad.mit.edu	37	19	9868262	9868262	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:9868262T>C	uc002mmb.1	-	6	2022	c.1491A>G	c.(1489-1491)ACA>ACG	p.T497T	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Silent_p.T368T	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	497	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTGAGTTCGTGTGTGAACGT	0.403			NA											12	80					0	0	0.000978	0	0
S1PR5	53637	broad.mit.edu	37	19	10624666	10624666	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:10624666G>C	uc002mot.1	-	2	1079	c.1022C>G	c.(1021-1023)GCG>GGG	p.A341G	S1PR5_uc002mou.1_Missense_Mutation_p.A341G	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	341	Cytoplasmic (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						AGCCTCAGCCGCGCTCGCCGA	0.746			NA											5	3					0	0	0.000602	0	0
TSPAN16	26526	broad.mit.edu	37	19	11411906	11411906	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:11411906C>A	uc002mqv.1	+	4	522	c.372C>A	c.(370-372)TTC>TTA	p.F124L	TSPAN16_uc002mqu.1_RNA|uc002mqw.1_RNA	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	124	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AACACACCTTCGTGACCCTGA	0.483			NA											9	21					0.000442599	0.000568128	0.006214	1	0
ZNF440	126070	broad.mit.edu	37	19	11943196	11943196	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:11943196G>T	uc002msp.1	+	4	1361	c.1205G>T	c.(1204-1206)GGG>GTG	p.G402V		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	402	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGCAATGTGGGAAAGCCTTC	0.458			NA											16	52					2.72e-22	5.40196e-22	0.006122	1	0
ILVBL	10994	broad.mit.edu	37	19	15233752	15233752	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:15233752A>T	uc002nam.2	-	5	676	c.555T>A	c.(553-555)ATT>ATA	p.I185I	ILVBL_uc010dzw.2_Silent_p.I78I|ILVBL_uc010dzx.1_Silent_p.I185I	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	185						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						GGGTGGGCACAATGTCCCGCA	0.647			NA											5	60					0	0	0.00308	0	0
NOTCH3	4854	broad.mit.edu	37	19	15273348	15273348	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:15273348C>A	uc002nan.2	-	32	5917	c.5841G>T	c.(5839-5841)GCG>GCT	p.A1947A		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1947	Cytoplasmic (Potential).|ANK 4.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGTTCACAGCCGCAGCCCAGT	0.577			NA											3	21					0.004672	0.00544907	0.004672	1	0
NOTCH3	4854	broad.mit.edu	37	19	15298035	15298035	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:15298035T>C	uc002nan.2	-	11	1797	c.1721A>G	c.(1720-1722)TAC>TGC	p.Y574C	NOTCH3_uc002nao.1_Missense_Mutation_p.Y574C	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	574	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGTGCCCGTGTAGCCAGGAGC	0.642			NA											3	29					0	0	0.004672	0	0
CYP4F12	66002	broad.mit.edu	37	19	15807280	15807280	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:15807280G>T	uc002nbl.2	+	12	1416	c.1355G>T	c.(1354-1356)GGG>GTG	p.G452V		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					AACAGCAAGGGGAGGTCACCT	0.547			NA											14	119					7.93312e-07	1.24304e-06	0.00245	1	0
USHBP1	83878	broad.mit.edu	37	19	17366264	17366264	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:17366264C>T	uc002nfs.1	-	10	1735	c.1622G>A	c.(1621-1623)GGT>GAT	p.G541D	USHBP1_uc002nfr.1_Missense_Mutation_p.G167D|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.G477D	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	541							PDZ domain binding			ovary(1)	1						GTTTGCCCCACCAGCCTGGAG	0.682			NA											7	73					0	0	0.001984	0	0
JAK3	3718	broad.mit.edu	37	19	17949121	17949121	+	Missense_Mutation	SNP	T	T	C	rs140690573		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:17949121T>C	uc002nhn.3	-	11	1620	c.1520A>G	c.(1519-1521)CAG>CGG	p.Q507R	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.Q507R|JAK3_uc010xpx.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	507					B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CTGACTCAGCTGGTATTGGGA	0.547			2	Mis		acute megakaryocytic leukemia|								21	129					0	0	0.002299	0	0
PIK3R2	5296	broad.mit.edu	37	19	18273927	18273927	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:18273927G>C	uc002nia.1	+	10	1772	c.1260G>C	c.(1258-1260)CGG>CGC	p.R420R	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	420	SH2 1.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						TGGACACACGGCTCCTCTACC	0.597			NA											9	27					0	0	0.008291	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368671	18368671	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:18368671C>A	uc002nin.2	-	4	3078	c.2862G>T	c.(2860-2862)ATG>ATT	p.M954I	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Missense_Mutation_p.M1141I|KIAA1683_uc010xqe.1_Missense_Mutation_p.M908I|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	954	IQ 2.|IQ 3.					mitochondrion				ovary(2)	2						CTTGGATGACCATGGCCCCCC	0.667			NA											10	63					7.03913e-09	1.21342e-08	0.001368	1	0
GATAD2A	54815	broad.mit.edu	37	19	19606889	19606889	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:19606889G>C	uc010xqt.1	+	7	1097	c.785G>C	c.(784-786)AGC>ACC	p.S262T	GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Missense_Mutation_p.S281T|GATAD2A_uc010xqw.1_Missense_Mutation_p.S89T	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	262					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CAACATTCCAGCACAGGGCCA	0.617			NA											8	32					0	0	0.004482	0	0
ZNF93	81931	broad.mit.edu	37	19	20027413	20027413	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:20027413G>T	uc002non.2	+	3	286	c.175G>T	c.(175-177)GGA>TGA	p.G59*	ZNF93_uc002nom.2_Nonsense_Mutation_p.G59*	NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	59	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						TCTGGAGCAAGGAAAAAAACC	0.408			NA											10	68					0.000442599	0.000568128	0.006214	1	0
LOC284441	284441	broad.mit.edu	37	19	20370053	20370053	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:20370053T>C	uc002nov.2	+	1	1597	c.846T>C	c.(844-846)CTT>CTC	p.L282L		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						CGGAAAAACTTCCTAAATTTA	0.418			NA											3	31					0	0	0.004672	0	0
ZNF85	7639	broad.mit.edu	37	19	21131981	21131981	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:21131981A>T	uc002npg.3	+	4	788	c.661A>T	c.(661-663)AAG>TAG	p.K221*	ZNF85_uc010ecn.2_Nonsense_Mutation_p.K156*|ZNF85_uc010eco.2_Nonsense_Mutation_p.K169*|ZNF85_uc002npi.2_Nonsense_Mutation_p.K162*	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	221	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						TACTAAACATAAGAGAATTCA	0.348			NA											8	34					0	0	0.004482	0	0
ZNF493	284443	broad.mit.edu	37	19	21607572	21607572	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:21607572A>T	uc002npx.2	+	2	2007	c.1727A>T	c.(1726-1728)AAG>ATG	p.K576M	ZNF493_uc002npw.2_Missense_Mutation_p.K704M|ZNF493_uc002npy.2_Missense_Mutation_p.K576M	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	576	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AATACGCATAAGATAATTCAT	0.333			NA											4	27					0	0	0.000248	0	0
ZNF208	7757	broad.mit.edu	37	19	22155210	22155210	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:22155210G>T	uc002nqp.2	-	5	2475	c.2326C>A	c.(2326-2328)CTT>ATT	p.L776I	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGATAACTAAGGGTTGAGGGC	0.363			NA											9	62					7.48243e-07	1.17892e-06	0.006214	1	0
ZNF208	7757	broad.mit.edu	37	19	22157345	22157345	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:22157345T>C	uc002nqp.2	-	4	640	c.491A>G	c.(490-492)AAG>AGG	p.K164R	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATGCCTTATCTTATGTCTGTT	0.313			NA											7	82					0	0	0.001984	0	0
ZNF492	57615	broad.mit.edu	37	19	22847741	22847741	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:22847741G>A	uc002nqw.3	+	4	1514	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	424	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				CTACAAATGTGAAGAATGTGG	0.378			NA											11	64					0	0	0.001855	0	0
ZNF536	9745	broad.mit.edu	37	19	30935931	30935931	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:30935931C>A	uc002nsu.1	+	2	1600	c.1462C>A	c.(1462-1464)CTC>ATC	p.L488I	ZNF536_uc010edd.1_Missense_Mutation_p.L488I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAAGCACTCCCTCCTGGGATG	0.652			NA											7	54					1.58986e-06	2.46733e-06	0.008291	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769270	31769270	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:31769270C>A	uc002nsy.3	-	2	1494	c.1429G>T	c.(1429-1431)GAG>TAG	p.E477*		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	477					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					ACCGCTTTCTCCTTGTCGACT	0.507			NA											32	205					1.56442e-22	3.1124e-22	0.002445	1	0
FFAR2	2867	broad.mit.edu	37	19	35941483	35941483	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:35941483G>T	uc002nzg.2	+	2	947	c.867G>T	c.(865-867)CAG>CAT	p.Q289H	FFAR2_uc010eea.2_Missense_Mutation_p.Q289H	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	289	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GAGGGCTGCAGGTGCTGCGGA	0.577	GBM(40;139 809 9833 23358 48736)		NA											16	82					2.31682e-05	3.32732e-05	0.003163	1	0
MLL4	9757	broad.mit.edu	37	19	36212499	36212499	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:36212499C>T	uc010eei.2	+	3	2250	c.2250C>T	c.(2248-2250)CCC>CCT	p.P750P		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	750	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGCTCCTGCCCCAGGCACTAC	0.667			NA											9	26					0	0	0.006214	0	0
MLL4	9757	broad.mit.edu	37	19	36227603	36227603	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:36227603G>T	uc010eei.2	+	32	7172	c.7172G>T	c.(7171-7173)AGC>ATC	p.S2391I		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2391					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGGCTTCGAGCTCTGAGGAA	0.582			NA											5	19					0.000602214	0.000754262	0.000602	1	0
NPHS1	4868	broad.mit.edu	37	19	36340177	36340177	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:36340177G>T	uc002oby.2	-	7	801	c.801C>A	c.(799-801)GCC>GCA	p.A267A		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	267	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TACCCCCTCGGGCCACGCACG	0.662			NA											5	37					0.000602214	0.000754262	0.000602	1	0
KIRREL2	84063	broad.mit.edu	37	19	36349667	36349667	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:36349667T>A	uc002ocb.3	+	4	635	c.423T>A	c.(421-423)CCT>CCA	p.P141P	KIRREL2_uc002obz.3_Silent_p.P141P|KIRREL2_uc002oca.3_Silent_p.P91P|KIRREL2_uc002occ.3_Silent_p.P88P|KIRREL2_uc002ocd.3_Silent_p.P138P	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	141	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGGAGTTCCTGCGAACCTGA	0.617			NA											16	74					0	0	0.00499	0	0
APLP1	333	broad.mit.edu	37	19	36369812	36369812	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:36369812G>T	uc002oce.2	+	15	1806	c.1668G>T	c.(1666-1668)AGG>AGT	p.R556S	APLP1_uc010xsz.1_Missense_Mutation_p.R517S|APLP1_uc002ocf.2_Missense_Mutation_p.R557S|APLP1_uc002ocg.2_Missense_Mutation_p.R460S|APLP1_uc010xta.1_Missense_Mutation_p.R550S	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	556	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGTTCCAAGGGGTTTCCCTT	0.577			NA											13	62					1.05317e-09	1.86355e-09	0.00245	1	0
WDR62	284403	broad.mit.edu	37	19	36558728	36558728	+	Splice_Site	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:36558728A>T	uc002odc.2	+	7	791	c.700_splice	c.e7-2	p.V234_splice	WDR62_uc002odd.2_Splice_Site_p.V234_splice|WDR62_uc002odb.2_Splice_Site_p.V234_splice	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2						cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTGTGTCTCCAGGTGACGAGC	0.582			NA											11	45					0	0	0.000978	0	0
ZNF568	374900	broad.mit.edu	37	19	37441368	37441368	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:37441368G>T	uc002ofc.2	+	7	1828	c.1313G>T	c.(1312-1314)CGA>CTA	p.R438L	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.R362L|ZNF568_uc010efe.2_Missense_Mutation_p.R362L|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	438	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTACATATGCGAAATCATACA	0.393			NA											12	65					0.00136819	0.00166946	0.001368	1	0
ZNF585A	199704	broad.mit.edu	37	19	37643910	37643910	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:37643910T>A	uc002ofo.1	-	5	1122	c.891A>T	c.(889-891)CCA>CCT	p.P297P	ZNF585A_uc002ofm.1_Silent_p.P242P|ZNF585A_uc002ofn.1_Silent_p.P242P	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCACTCATATGGTTTTTCTC	0.428			NA											47	175					0	0	0.00361	0	0
ZNF569	148266	broad.mit.edu	37	19	37904988	37904988	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:37904988C>G	uc002ogi.2	-	6	1130	c.572G>C	c.(571-573)TGT>TCT	p.C191S	ZNF569_uc002ogh.2_Missense_Mutation_p.C32S|ZNF569_uc002ogj.2_Missense_Mutation_p.C215S	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	191	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCCTTTTCCACAATGATTACA	0.383			NA											10	52					0	0	0.008291	0	0
RASGRP4	115727	broad.mit.edu	37	19	38910858	38910858	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:38910858T>A	uc002oir.2	-	5	636	c.422A>T	c.(421-423)CAG>CTG	p.Q141L	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Missense_Mutation_p.Q141L|RASGRP4_uc010xub.1_Missense_Mutation_p.Q141L|RASGRP4_uc010xuc.1_Missense_Mutation_p.Q141L|RASGRP4_uc010xud.1_Missense_Mutation_p.Q141L|RASGRP4_uc010xue.1_Missense_Mutation_p.Q141L|RASGRP4_uc010egb.2_Missense_Mutation_p.Q141L	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	141	N-terminal Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TTCTTCTAGCTGGGGATCCTG	0.587			NA											6	13					0	0	0.001168	0	0
RYR1	6261	broad.mit.edu	37	19	39009862	39009862	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:39009862C>G	uc002oit.2	+	67	10157	c.10027C>G	c.(10027-10029)CAG>GAG	p.Q3343E	RYR1_uc002oiu.2_Missense_Mutation_p.Q3343E|RYR1_uc002oiv.1_Missense_Mutation_p.Q263E|RYR1_uc010xuf.1_Missense_Mutation_p.Q263E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3343					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGTGTTCGCACAGCCCATTGT	0.642			NA											24	102					0	0	0.002299	0	0
SPTBN4	57731	broad.mit.edu	37	19	40995992	40995992	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:40995992C>A	uc002ony.2	+	4	418	c.332C>A	c.(331-333)ACG>AAG	p.T111K	SPTBN4_uc002onx.2_Missense_Mutation_p.T111K|SPTBN4_uc002onz.2_Missense_Mutation_p.T111K	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	111	CH 1.|Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCCAGGCCCACGCGCGGCCGC	0.672			NA											4	12					0.000602214	0.000754262	0.000602	1	0
TMEM145	284339	broad.mit.edu	37	19	42824590	42824590	+	Splice_Site	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:42824590G>C	uc002otk.1	+	13	1246	c.1194_splice	c.e13+1	p.L398_splice		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145							integral to membrane					0		Prostate(69;0.00682)				CGTGTTTCTGGTGAGGATGGG	0.592			NA											3	72					0	0	0.000248	0	0
PSG11	5680	broad.mit.edu	37	19	43523068	43523068	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:43523068G>T	uc002ovm.1	-	3	670	c.563C>A	c.(562-564)CCT>CAT	p.P188H	PSG11_uc002ouw.2_Missense_Mutation_p.P194H|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.P194H|PSG11_uc002ovn.1_Missense_Mutation_p.P194H|PSG11_uc002ovo.1_Missense_Mutation_p.P66H|PSG11_uc002ovp.1_Missense_Mutation_p.P66H	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	188	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				ATGAGTCATAGGGAGGCTCTG	0.478			NA											53	275					1.19403e-26	2.38807e-26	0.00361	1	0
PSG6	5675	broad.mit.edu	37	19	43528960	43528960	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:43528960C>A	uc002ovh.1	-	2	420	c.331G>T	c.(331-333)GCA>TCA	p.A111S	PSG11_uc002ouw.2_Missense_Mutation_p.A111S|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.A111S|PSG11_uc002ovm.1_Missense_Mutation_p.A105S|PSG11_uc002ovn.1_Missense_Mutation_p.A111S|PSG11_uc002ovo.1_Intron|PSG11_uc002ovp.1_Intron			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	104	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				AGCAGGGATGCATTGGAATAT	0.438			NA											30	188					2.40579e-17	4.69584e-17	0.00623	1	0
PSG2	5670	broad.mit.edu	37	19	43575948	43575948	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:43575948G>A	uc002ovr.2	-	4	961	c.868C>T	c.(868-870)CAA>TAA	p.Q290*	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Nonsense_Mutation_p.Q290*|PSG2_uc010eiq.1_Nonsense_Mutation_p.Q290*|PSG2_uc002ovs.3_Nonsense_Mutation_p.Q290*|PSG2_uc002ovt.3_Nonsense_Mutation_p.Q290*	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	290	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTAGTAATTTGGGGGATAAAC	0.458			NA											34	164					0	0	0.003755	0	0
PSG2	5670	broad.mit.edu	37	19	43579540	43579540	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:43579540G>A	uc002ovr.2	-	3	768	c.675C>T	c.(673-675)GCC>GCT	p.A225A	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.A225A|PSG2_uc010eiq.1_Silent_p.A225A|PSG2_uc002ovs.3_Silent_p.A225A|PSG2_uc002ovt.3_Silent_p.A225A	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	225	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				CACTGCGGCTGGCACTCCCTG	0.527			NA											29	263					0	0	0.001786	0	0
PSG4	5672	broad.mit.edu	37	19	43702333	43702333	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:43702333G>T	uc002ovy.2	-	3	627	c.525C>A	c.(523-525)GCC>GCA	p.A175A	PSG6_uc010xwk.1_Silent_p.A14A|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Intron|PSG4_uc002ovz.2_Silent_p.A175A	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	175	Ig-like C2-type 1.			A -> P (in Ref. 1; M32624).	defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GGTAGCTTGCGGCTGGAGTCG	0.532			NA											42	188					9.85913e-13	1.86356e-12	0.002222	1	0
IRGC	56269	broad.mit.edu	37	19	44223254	44223254	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:44223254C>T	uc002oxh.2	+	2	691	c.544C>T	c.(544-546)CCG>TCG	p.P182S		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	182						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CACCCAGCGGCCGTCGGGCTT	0.682	Colon(189;350 2037 11447 13433 38914)		NA											4	29					0	0	0.000602	0	0
ZNF225	7768	broad.mit.edu	37	19	44636290	44636290	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:44636290G>C	uc002oyj.1	+	5	1766	c.1523G>C	c.(1522-1524)GGA>GCA	p.G508A	ZNF225_uc010eje.1_Missense_Mutation_p.G425A|ZNF225_uc010ejf.1_Missense_Mutation_p.G508A	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				GTCCACAGTGGAGAAAAACCA	0.378			NA											21	50					0	0	0.002299	0	0
ZNF227	7770	broad.mit.edu	37	19	44739160	44739160	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:44739160A>C	uc002oyu.2	+	6	782	c.577A>C	c.(577-579)AAG>CAG	p.K193Q	ZNF227_uc010xwu.1_Missense_Mutation_p.K142Q|ZNF227_uc002oyv.2_Missense_Mutation_p.K193Q|ZNF227_uc010xwv.1_Missense_Mutation_p.K142Q|ZNF227_uc010xww.1_Missense_Mutation_p.K114Q|ZNF227_uc002oyw.2_Missense_Mutation_p.K165Q|ZNF227_uc010ejh.2_Missense_Mutation_p.K186Q|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				GAGTAGAGGTAAGCAAATTGA	0.358			NA											7	31					0	0	0.001984	0	0
CEACAM20	125931	broad.mit.edu	37	19	45015707	45015707	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:45015707C>T	uc010ejn.1	-	11	1615	c.1599G>A	c.(1597-1599)GAG>GAA	p.E533E	CEACAM20_uc010ejo.1_Intron|CEACAM20_uc010ejp.1_Silent_p.E440E|CEACAM20_uc010ejq.1_Intron	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	533	Cytoplasmic (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				CATAGGTCTCCTCTGGAAGGT	0.383			NA											5	12					0	0	0.000602	0	0
BCL3	602	broad.mit.edu	37	19	45262791	45262791	+	Silent	SNP	A	A	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:45262791A>C	uc010xxe.1	+	9	1354	c.1284A>C	c.(1282-1284)CCA>CCC	p.P428P		NM_005178	NP_005169	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	428	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			ovary(1)|lung(1)	2	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CCCCATCTCCACCCGCCTTCC	0.682			NA	T	IGH@	CLL 								12	162					0	0	0.007291	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45901276	45901276	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:45901276C>A	uc002pbn.2	-	3	262	c.185G>T	c.(184-186)GGA>GTA	p.G62V	PPP1R13L_uc002pbo.2_Missense_Mutation_p.G62V|PPP1R13L_uc002pbp.2_Missense_Mutation_p.G62V	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	62	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		AGAAGGGGGTCCGGCCTGCGG	0.627	Pancreas(61;1447 1663 31419 50578)		NA											6	33					0.00116845	0.00142726	0.001168	1	0
NOVA2	4858	broad.mit.edu	37	19	46443365	46443365	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:46443365G>A	uc002pdv.2	-	4	1283	c.1235C>T	c.(1234-1236)GCG>GTG	p.A412V		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	412	KH 3.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		CTCAGGCACCGCAATCTCCAC	0.488			NA											4	100					0	0	0.000602	0	0
C5AR1	728	broad.mit.edu	37	19	47823415	47823415	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:47823415G>T	uc002pgj.1	+	2	430	c.381G>T	c.(379-381)CTG>CTT	p.L127L		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	127	Helical; Name=3; (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		TCCTGCTCCTGGCCACCATCA	0.622			NA											17	66					1.99824e-07	3.27089e-07	0.00499	1	0
TRPM4	54795	broad.mit.edu	37	19	49684691	49684691	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:49684691A>T	uc002pmw.2	+	10	1308	c.1236A>T	c.(1234-1236)GAA>GAT	p.E412D	TRPM4_uc010emu.2_Missense_Mutation_p.E412D|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_Missense_Mutation_p.E238D|TRPM4_uc010emv.2_Missense_Mutation_p.E297D|TRPM4_uc010yal.1_Intron|TRPM4_uc002pmy.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	412	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CCCAGAGTGAACTCTTTCGGG	0.592			NA											4	31					0	0	0.000248	0	0
CPT1C	126129	broad.mit.edu	37	19	50216267	50216267	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:50216267G>T	uc002ppj.2	+	18	2377	c.2172G>T	c.(2170-2172)ATG>ATT	p.M724I	CPT1C_uc002ppi.2_Missense_Mutation_p.M641I|CPT1C_uc002ppk.2_Missense_Mutation_p.M713I|CPT1C_uc010eng.2_Missense_Mutation_p.M724I|CPT1C_uc010enh.2_Missense_Mutation_p.M724I|CPT1C_uc010eni.1_Missense_Mutation_p.M292I	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	724	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		ATATCTTCATGGGGGATGGCA	0.408			NA											15	188					0.006122	0.00713292	0.006122	1	0
C19orf41	126123	broad.mit.edu	37	19	50657931	50657931	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:50657931C>A	uc002prp.1	-	6	636	c.549G>T	c.(547-549)CCG>CCT	p.P183P		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	183	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		CCTGGTTCCTCGGGTATTTGC	0.622			NA											4	65					0.00024832	0.000325365	0.000248	1	0
MYBPC2	4606	broad.mit.edu	37	19	50958471	50958471	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:50958471C>A	uc002psf.2	+	19	2172	c.2121C>A	c.(2119-2121)ATC>ATA	p.I707I		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	707	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TCGAGGGCATCCTCTATGAGA	0.517			NA											5	84					2.0095e-06	3.08069e-06	0.001984	1	0
GPR32	2854	broad.mit.edu	37	19	51274753	51274753	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:51274753A>C	uc010ycf.1	+	1	896	c.896A>C	c.(895-897)CAG>CCG	p.Q299P		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	299	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTCATCCTCCAGGCTAGCTTT	0.517	Esophageal Squamous(113;152 1581 5732 15840 44398)		NA											7	65					0	0	0.006214	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51630361	51630361	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:51630361G>C	uc002pvu.2	+	4	890	c.823G>C	c.(823-825)GAT>CAT	p.D275H	SIGLEC9_uc010yct.1_Missense_Mutation_p.D275H	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	275	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTGTGCAGTTGATGCAGTTGA	0.547			NA											12	66					0	0	0.001368	0	0
CD33	945	broad.mit.edu	37	19	51738451	51738451	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:51738451T>C	uc002pwa.2	+	5	825	c.785T>C	c.(784-786)ATT>ACT	p.I262T	CD33_uc010eos.1_Missense_Mutation_p.I262T|CD33_uc010eot.1_Missense_Mutation_p.I135T|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	262	Helical; (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CATGGGGCCATTGGAGGAGCT	0.493			NA											8	39					0	0	0.004482	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51919589	51919589	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:51919589G>A	uc002pwo.2	-	4	1345	c.729C>T	c.(727-729)ATC>ATT	p.I243I	SIGLEC10_uc002pwp.2_Silent_p.I185I|SIGLEC10_uc002pwq.2_Silent_p.I185I|SIGLEC10_uc002pwr.2_Silent_p.I243I|SIGLEC10_uc010ycy.1_Silent_p.I243I|SIGLEC10_uc010ycz.1_Silent_p.I195I|SIGLEC10_uc010eow.2_Missense_Mutation_p.S8L|SIGLEC10_uc002pws.1_Silent_p.I169I	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	243	Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GTGAAATGCTGATAACAAGGT	0.527			NA											18	85					0	0	0.001523	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52132675	52132675	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:52132675G>T	uc002pxe.2	-	3	775	c.636C>A	c.(634-636)ACC>ACA	p.T212T		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	212	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TCATCTGACAGGTGAGGTTGG	0.637			NA											8	51					0.00448238	0.00529312	0.004482	1	0
ZNF616	90317	broad.mit.edu	37	19	52618394	52618394	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:52618394T>A	uc002pym.2	-	4	2306	c.2023A>T	c.(2023-2025)AAC>TAC	p.N675Y	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	675	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GCAGTGAGGTTTGAGCTCCGT	0.403			NA											11	140					0	0	0.008291	0	0
ZNF578	147660	broad.mit.edu	37	19	53015127	53015127	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:53015127T>C	uc002pzp.3	+	6	1737	c.1493T>C	c.(1492-1494)CTT>CCT	p.L498P		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	273	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		AGGTCATCTCTTCCATGCCAT	0.398			NA											13	68					0	0	0.003163	0	0
ZNF611	81856	broad.mit.edu	37	19	53208789	53208789	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:53208789C>T	uc002pzz.2	-	7	1836	c.1519G>A	c.(1519-1521)GAG>AAG	p.E507K	ZNF611_uc010eqc.2_Missense_Mutation_p.E437K|ZNF611_uc010ydo.1_Missense_Mutation_p.E437K|ZNF611_uc010ydr.1_Missense_Mutation_p.E438K|ZNF611_uc010ydp.1_Missense_Mutation_p.E507K|ZNF611_uc010ydq.1_Missense_Mutation_p.E507K|ZNF611_uc002qaa.3_Missense_Mutation_p.E437K	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TAAGGTTGCTCCCCAGTATGA	0.358			NA											36	113					0	0	0.003271	0	0
ZNF320	162967	broad.mit.edu	37	19	53383932	53383932	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:53383932G>T	uc002qag.2	-	4	1638	c.1447C>A	c.(1447-1449)CTC>ATC	p.L483I	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.L429I|ZNF320_uc002qai.2_Missense_Mutation_p.L483I	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	483	C2H2-type 12; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TCTGCAAGGAGTGACCTCAGA	0.383			NA											12	54					0.000978159	0.00121441	0.000978	1	0
NLRP12	91662	broad.mit.edu	37	19	54314539	54314539	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:54314539G>C	uc002qch.3	-	3	594	c.374C>G	c.(373-375)CCC>CGC	p.P125R	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.P125R|NLRP12_uc002qcj.3_Missense_Mutation_p.P125R|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.P125R	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	125					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GGTTTCCTGGGGATCTAGGGG	0.517			NA											9	66					0	0	0.006214	0	0
LILRB3	11025	broad.mit.edu	37	19	54721091	54721091	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:54721091G>C	uc002qef.1	-	13	1878	c.1767C>G	c.(1765-1767)GCC>GCG	p.A589A	LILRB3_uc002qee.1_Silent_p.A590A|LILRB3_uc002qeh.1_Silent_p.A589A|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Silent_p.A589A|LILRA6_uc002qek.1_Silent_p.A590A|LILRB3_uc010erh.1_Silent_p.A606A|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Silent_p.A589A|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.A590A|LILRB3_uc002qep.1_Silent_p.A590A|LILRB3_uc002qeq.1_Silent_p.A589A|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.A590A	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	589	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CATCCTGGGAGGCTTCAGATG	0.632			NA											9	26					0	0	0.004482	0	0
LILRB4	11006	broad.mit.edu	37	19	55175015	55175015	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:55175015C>A	uc002qgp.2	+	2	422	c.60C>A	c.(58-60)CAC>CAA	p.H20Q	LILRB4_uc002qgo.1_Missense_Mutation_p.H61Q|LILRB4_uc002qgq.2_Missense_Mutation_p.H20Q|LILRB4_uc010ers.1_Intron|LILRB4_uc002qgr.2_Missense_Mutation_p.H61Q|LILRB4_uc010ert.2_Missense_Mutation_p.H61Q|LILRB4_uc010eru.2_Intron	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	20						integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CCAGGACCCACATGCAGGCAG	0.607			NA											13	50					7.93312e-07	1.24304e-06	0.00245	1	0
KIR3DL1	3811	broad.mit.edu	37	19	55330026	55330026	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:55330026C>A	uc002qhk.3	+	3	390	c.327C>A	c.(325-327)CCC>CCA	p.P109P	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Silent_p.P51P|KIR3DL1_uc010esf.2_Intron|KIR3DL1_uc010yfo.1_Silent_p.P51P|KIR3DL1_uc002qhl.3_Silent_p.P109P	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	109	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GGTCGGCACCCAGCAACCCCG	0.602			NA											16	99					3.32936e-07	5.31948e-07	0.006122	1	0
BRSK1	84446	broad.mit.edu	37	19	55817713	55817713	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:55817713C>T	uc002qkg.2	+	17	2261	c.1984C>T	c.(1984-1986)CGC>TGC	p.R662C	BRSK1_uc002qkf.2_Missense_Mutation_p.R678C|BRSK1_uc002qkh.2_Missense_Mutation_p.R357C	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	662					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AAAGCCCGTCCGCTTCCAGGT	0.637			NA											13	51					0	0	0.001368	0	0
NLRP13	126204	broad.mit.edu	37	19	56436007	56436008	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:56436007_56436008CC>AA	uc010ygg.1	-	3	430_431	c.405_406GG>TT	c.(403-408)CAGGGA>CATTGA	p.135_136QG>H*		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	135_136							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCTTGGCATCCCTGGGTCTGCA	0.426			NA											9	55					0	0	0.004672	0	0
PEG3	5178	broad.mit.edu	37	19	57327572	57327572	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:57327572G>T	uc002qnu.2	-	7	2589	c.2238C>A	c.(2236-2238)GAC>GAA	p.D746E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.D717E|PEG3_uc002qnv.2_Missense_Mutation_p.D746E|PEG3_uc002qnw.2_Missense_Mutation_p.D622E|PEG3_uc002qnx.2_Missense_Mutation_p.D620E|PEG3_uc010etr.2_Missense_Mutation_p.D746E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	746					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACGCCTTTTCGTCCTCATCAC	0.408			NA											33	144					8.53417e-09	1.46891e-08	0.002836	1	0
AURKC	6795	broad.mit.edu	37	19	57743931	57743931	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:57743931G>T	uc002qoe.2	+	4	507	c.318G>T	c.(316-318)CTG>CTT	p.L106L	AURKC_uc002qoc.2_Silent_p.L87L|AURKC_uc002qod.2_Silent_p.L72L|AURKC_uc010etv.2_Silent_p.L103L	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	106	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		TCCTGCGCCTGTATAACTATT	0.483			NA											18	65					2.94398e-08	4.97673e-08	0.007413	1	0
ZNF543	125919	broad.mit.edu	37	19	57839241	57839241	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:57839241A>T	uc002qoi.1	+	4	756	c.411A>T	c.(409-411)ATA>ATT	p.I137I		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ACTTGAAAATAGGGATAGGCC	0.478			NA											6	39					0	0	0.00308	0	0
ZNF8	7554	broad.mit.edu	37	19	58806148	58806148	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:58806148G>T	uc002qry.1	+	4	1104	c.974G>T	c.(973-975)AGT>ATT	p.S325I	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	325	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		TTCTGCCATAGTACACACCTT	0.567			NA											8	45					0.000274275	0.000355681	0.004482	1	0
C2orf48	348738	broad.mit.edu	37	2	10350553	10350553	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:10350553G>A	uc002rai.1	+	4	599	c.310G>A	c.(310-312)GGG>AGG	p.G104R		NM_182626	NP_872432	Q96LS8	CB048_HUMAN	hypothetical protein LOC348738	104											0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		CTTCCAGACAGGGACACCCCT	0.567			NA											9	42					0	0	0.008291	0	0
NBAS	51594	broad.mit.edu	37	2	15358968	15358968	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:15358968C>G	uc002rcc.1	-	48	6387	c.6361G>C	c.(6361-6363)GAG>CAG	p.E2121Q	NBAS_uc002rcb.1_Intron|NBAS_uc010exl.1_Missense_Mutation_p.E1193Q|NBAS_uc002rcd.1_Intron	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	2121										ovary(2)|liver(1)|skin(1)	4						CTGTCCTCCTCAGTCAGGTGA	0.547			NA											5	58					0	0	0.000602	0	0
FKBP1B	2281	broad.mit.edu	37	2	24276809	24276809	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:24276809G>A	uc002rer.2	+	2	211	c.75G>A	c.(73-75)GTG>GTA	p.V25V	FKBP1B_uc002res.2_Silent_p.V25V|FKBP1B_uc002ret.2_RNA|FKBP1B_uc002reu.2_RNA	NM_004116	NP_004107	P68106	FKB1B_HUMAN	FK506 binding protein 1B, 12.6 kDa isoform a	25	PPIase FKBP-type.				'de novo' protein folding|negative regulation of heart rate|negative regulation of protein phosphatase type 2B activity|protein maturation by protein folding|protein refolding|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of ryanodine-sensitive calcium-release channel activity|response to redox state	calcium channel complex|sarcoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTGTGTGGTGCACTACACAG	0.567			NA											4	47					0	0	0.000248	0	0
PLB1	151056	broad.mit.edu	37	2	28755041	28755041	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:28755041C>T	uc002rmb.1	+	9	535	c.535C>T	c.(535-537)CTG>TTG	p.L179L	PLB1_uc010ezj.1_Silent_p.L179L	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	179	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CCAGTGTTACCTGTGCCCCTC	0.468			NA											19	115					0	0	0.007413	0	0
GALNT14	79623	broad.mit.edu	37	2	31165143	31165143	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:31165143G>T	uc002rnr.2	-	9	1474	c.855C>A	c.(853-855)TTC>TTA	p.F285L	GALNT14_uc002rnq.2_Missense_Mutation_p.F265L|GALNT14_uc002rns.2_Missense_Mutation_p.F290L|GALNT14_uc010ymr.1_Missense_Mutation_p.F250L|GALNT14_uc010ezo.1_Missense_Mutation_p.F252L|GALNT14_uc010ezp.1_Intron	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	285	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TGTCGATCACGAAGAGCCCTC	0.498			NA											15	40					4.14922e-12	7.76526e-12	0.004007	1	0
GALNT14	79623	broad.mit.edu	37	2	31215704	31215704	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:31215704C>A	uc002rnr.2	-	2	918	c.299G>T	c.(298-300)AGA>ATA	p.R100I	GALNT14_uc002rnq.2_Missense_Mutation_p.R80I|GALNT14_uc002rns.2_Intron|GALNT14_uc010ymr.1_Missense_Mutation_p.R65I|GALNT14_uc010ezo.1_Missense_Mutation_p.S100I|GALNT14_uc010ezp.1_Missense_Mutation_p.R71I	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	100	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GAGGAAGTACCTCAGATGGCG	0.567			NA											15	65					6.94344e-10	1.23827e-09	0.006122	1	0
EHD3	30845	broad.mit.edu	37	2	31489370	31489370	+	Nonsense_Mutation	SNP	G	G	T	rs35925176		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:31489370G>T	uc002rnu.2	+	6	2016	c.1408G>T	c.(1408-1410)GAG>TAG	p.E470*	EHD3_uc010ymt.1_3'UTR	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	470	EH.				blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					TGCCAAGAAGGAGATGGTGCG	0.572			NA											13	25					0.00010058	0.00013651	0.001368	1	0
VIT	5212	broad.mit.edu	37	2	36994405	36994405	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:36994405T>A	uc002rpl.2	+	7	877	c.656T>A	c.(655-657)GTG>GAG	p.V219E	VIT_uc010ynf.1_Intron|VIT_uc002rpm.2_Missense_Mutation_p.V212E|VIT_uc010ezv.2_Missense_Mutation_p.V212E|VIT_uc010ezw.2_Missense_Mutation_p.V212E	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	219						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CCACAATCAGTGGGCCACAGG	0.552			NA											12	16					0	0	0.000978	0	0
PRKD3	23683	broad.mit.edu	37	2	37543459	37543459	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:37543459C>A	uc002rqd.2	-	1	764	c.209G>T	c.(208-210)CGG>CTG	p.R70L	PRKD3_uc002rqf.1_Missense_Mutation_p.R70L	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	70					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AACACTCTCCCGTGTGAGGCC	0.458	Melanoma(80;621 1355 8613 11814 51767)		NA											15	76					1.02788e-11	1.90175e-11	0.00499	1	0
SLC8A1	6546	broad.mit.edu	37	2	40655842	40655842	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:40655842C>A	uc002rrx.2	-	1	1603	c.1579G>T	c.(1579-1581)GCC>TCC	p.A527S	SLC8A1_uc002rry.2_Missense_Mutation_p.A527S|SLC8A1_uc002rrz.2_Missense_Mutation_p.A527S|SLC8A1_uc002rsa.2_Missense_Mutation_p.A527S|SLC8A1_uc002rsd.3_Missense_Mutation_p.A527S|SLC8A1_uc002rsb.1_Missense_Mutation_p.A527S|SLC8A1_uc010fan.1_Missense_Mutation_p.A527S|SLC8A1_uc002rsc.1_Missense_Mutation_p.A527S	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	527	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GTTACAGTGGCAGTGGAGGGA	0.448			NA											6	54					5.9392e-07	9.42309e-07	0.001168	1	0
ABCG8	64241	broad.mit.edu	37	2	44099139	44099139	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:44099139G>A	uc002rtq.2	+	7	1079	c.989G>A	c.(988-990)CGC>CAC	p.R330H	ABCG8_uc010yoa.1_Missense_Mutation_p.R330H	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	330	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATTGACAGGCGCAGCAGAGAG	0.557			NA											11	33					0	0	0.001368	0	0
SIX3	6496	broad.mit.edu	37	2	45169936	45169936	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:45169936C>A	uc002run.1	+	1	900	c.693C>A	c.(691-693)CCC>CCA	p.P231P		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	231	Homeobox.		P -> R (in HPE2).		visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACCCCTACCCCAACCCCAGCA	0.652			NA											4	22					0.000602214	0.000754262	0.000602	1	0
SRBD1	55133	broad.mit.edu	37	2	45646961	45646961	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:45646961C>G	uc002rus.2	-	17	2198	c.2122G>C	c.(2122-2124)GTG>CTG	p.V708L	SRBD1_uc010yoc.1_Missense_Mutation_p.V227L	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	708					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TTAATATCCACTCCCACAAAG	0.398			NA											5	62					0	0	0.000602	0	0
FSHR	2492	broad.mit.edu	37	2	49247236	49247236	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:49247236T>A	uc002rww.2	-	3	362	c.288A>T	c.(286-288)AAA>AAT	p.K96N	FSHR_uc002rwx.2_Missense_Mutation_p.K96N|FSHR_uc010fbn.2_Missense_Mutation_p.K96N|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	96	LRR 2.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TTTCATGTAATTTGGGAAGGT	0.418			NA							Gonadal_Dysgenesis_46_XX				80	236					0	0	0.00361	0	0
CCDC88A	55704	broad.mit.edu	37	2	55555429	55555429	+	Splice_Site	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:55555429C>A	uc002ryv.2	-	17	3836	c.2994_splice	c.e17+1	p.T998_splice	CCDC88A_uc010yoz.1_Splice_Site_p.T999_splice|CCDC88A_uc010ypa.1_Splice_Site_p.T998_splice|CCDC88A_uc002ryu.2_Splice_Site_p.T281_splice|CCDC88A_uc002rys.2_Intron|CCDC88A_uc002ryw.2_Splice_Site_p.T282_splice|CCDC88A_uc010fby.1_Intron	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1						activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						AAATCACTTACTGTTTTAAGT	0.259			NA											4	10					0.00024832	0.000325365	0.000248	1	0
USP34	9736	broad.mit.edu	37	2	61505300	61505300	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:61505300C>G	uc002sbe.2	-	41	5455	c.5433G>C	c.(5431-5433)CAG>CAC	p.Q1811H	USP34_uc002sbf.2_5'UTR	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1811					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TAACACTTACCTGTCCTTCCC	0.284			NA											5	18					0	0	0.000602	0	0
FAM161A	84140	broad.mit.edu	37	2	62054330	62054330	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:62054330C>A	uc010ypo.1	-	5	1849	c.1747G>T	c.(1747-1749)GAT>TAT	p.D583Y	FAM161A_uc002sbm.3_Missense_Mutation_p.D639Y|FAM161A_uc002sbn.3_Missense_Mutation_p.D393Y|FAM161A_uc010fcm.1_RNA	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	583					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						ACAAACTCATCAGATATTCCT	0.348			NA											28	78					3.96558e-24	7.91723e-24	0.004656	1	0
ARHGAP25	9938	broad.mit.edu	37	2	69049695	69049695	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:69049695C>A	uc002seu.2	+	10	1785	c.1421C>A	c.(1420-1422)TCA>TAA	p.S474*	ARHGAP25_uc010fdg.2_Nonsense_Mutation_p.S475*|ARHGAP25_uc010yql.1_Nonsense_Mutation_p.S435*|ARHGAP25_uc002sew.2_Nonsense_Mutation_p.S467*|ARHGAP25_uc002sex.2_Nonsense_Mutation_p.S468*|ARHGAP25_uc002sey.2_Nonsense_Mutation_p.S201*	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	474					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TCGCCTTCCTCAGAGGCTAAG	0.493			NA											18	68					8.28177e-16	1.60274e-15	0.007413	1	0
BMP10	27302	broad.mit.edu	37	2	69098246	69098246	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:69098246G>T	uc002sez.1	-	1	404	c.245C>A	c.(244-246)CCA>CAA	p.P82Q		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	82					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						CATGTACTCTGGTGGGTCCAC	0.458			NA											9	69					0.00448238	0.00529312	0.004482	1	0
LOXL3	84695	broad.mit.edu	37	2	74763528	74763528	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:74763528C>A	uc002smp.1	-	6	1055	c.983G>T	c.(982-984)TGG>TTG	p.W328L	LOXL3_uc002smo.1_5'UTR|LOXL3_uc010ffm.1_Missense_Mutation_p.W328L|LOXL3_uc002smq.1_Missense_Mutation_p.W183L|LOXL3_uc010ffn.1_Missense_Mutation_p.W183L	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	328	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						GACTGTGCCCCATGTGCTGGC	0.642			NA											20	35					1.37657e-19	2.71019e-19	0.001882	1	0
DOK1	1796	broad.mit.edu	37	2	74782721	74782721	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:74782721C>T	uc002sms.2	+	3	402	c.380C>T	c.(379-381)GCG>GTG	p.A127V	LOXL3_uc010ffm.1_5'Flank|LOXL3_uc002smp.1_5'Flank|LOXL3_uc002smq.1_5'Flank|LOXL3_uc010ffn.1_5'Flank|DOK1_uc002smr.2_5'UTR|DOK1_uc010ffo.2_5'UTR|DOK1_uc002smt.2_5'UTR|DOK1_uc002smu.2_5'UTR|DOK1_uc010yrz.1_Missense_Mutation_p.A116V|DOK1_uc002smv.2_5'UTR|DOK1_uc002smw.1_5'UTR	NM_001381	NP_001372	Q99704	DOK1_HUMAN	docking protein 1	127					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding				0						TGGACTCTGGCGCCTACCGAT	0.592	Esophageal Squamous(36;520 860 12502 33616 51270)		NA											4	36					0	0	0.000248	0	0
REG1B	5968	broad.mit.edu	37	2	79314050	79314050	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:79314050T>G	uc002sny.2	-	3	183	c.71A>C	c.(70-72)GAG>GCG	p.E24A	REG1B_uc010ffv.1_Missense_Mutation_p.E24A|REG1B_uc010ffw.2_Missense_Mutation_p.E24A	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	24					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						TGTCTGGGACTCCTGGCCTGG	0.488			NA											5	66					0	0	0.000602	0	0
REG1A	5967	broad.mit.edu	37	2	79348008	79348008	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:79348008C>A	uc002snz.2	+	2	124	c.21C>A	c.(19-21)TAC>TAA	p.Y7*	REG1A_uc010ffx.1_Nonsense_Mutation_p.Y7*|REG1A_uc010ysd.1_Nonsense_Mutation_p.Y7*	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	7				SSY -> NSF (in Ref. 3; AAA60546/ AAA60545).	positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CCAGCTCATACTTCATGCTGA	0.463			NA											8	42					0.000157383	0.000211083	0.00308	1	0
LRRTM1	347730	broad.mit.edu	37	2	80529463	80529463	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:80529463C>A	uc002sok.1	-	2	1752	c.1482G>T	c.(1480-1482)CCG>CCT	p.P494P	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	494	Cytoplasmic (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CAATGTGGTTCGGTTTGTAAT	0.547			NA								HNSCC(69;0.2)			10	30					3.86212e-05	5.4165e-05	0.008291	1	0
DUSP2	1844	broad.mit.edu	37	2	96809566	96809566	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:96809566T>C	uc002svk.3	-	4	1027	c.941A>G	c.(940-942)CAC>CGC	p.H314R		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	314					endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				ACCACCTCAGTGACACAGCAC	0.632			NA											4	12					0	0	0.000248	0	0
ARID5A	10865	broad.mit.edu	37	2	97217799	97217799	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:97217799A>T	uc002swe.2	+	7	1634	c.1534A>T	c.(1534-1536)ACT>TCT	p.T512S	ARID5A_uc010yuq.1_Missense_Mutation_p.T460S|ARID5A_uc002swf.2_Missense_Mutation_p.T348S|ARID5A_uc002swg.2_Missense_Mutation_p.T460S	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	512					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						GCTGAACTTCACTGGCACCCC	0.716			NA											6	58					0	0	0.001984	0	0
MFSD9	84804	broad.mit.edu	37	2	103335231	103335231	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:103335231C>A	uc002tcb.2	-	6	1141	c.1073G>T	c.(1072-1074)AGC>ATC	p.S358I	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	358					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						GGTGAGTATGCTGGAATGCAG	0.607			NA											14	26					3.27435e-08	5.51879e-08	0.00245	1	0
RGPD3	653489	broad.mit.edu	37	2	107041516	107041516	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:107041516A>G	uc010ywi.1	-	20	2964	c.2907T>C	c.(2905-2907)ACT>ACC	p.T969T		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	969					intracellular transport		binding			ovary(1)	1						CAAATGTAAAAGTGCTACTTG	0.408			NA											19	142					0	0	0.002445	0	0
SEPT10	151011	broad.mit.edu	37	2	110325410	110325410	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:110325410C>T	uc002tew.2	-	6	1123	c.744G>A	c.(742-744)AAG>AAA	p.K248K	SEPT10_uc010ywu.1_Silent_p.K81K|SEPT10_uc002tex.2_Silent_p.K225K|SEPT10_uc002tey.2_Silent_p.K248K|SEPT10_uc010ywv.1_Silent_p.K114K|SEPT10_uc002tev.1_Silent_p.K55K|SEPT10_uc010fjo.2_RNA|SEPT10_uc002tez.1_Silent_p.K23K	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	248					cell cycle|cell division	septin complex	GTP binding				0						CAGCGTTGACCTTAGCAATAG	0.373			NA											5	53					0	0	0.000602	0	0
NPHP1	4867	broad.mit.edu	37	2	110881425	110881425	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:110881425A>T	uc002tfn.3	-	20	2236	c.2142T>A	c.(2140-2142)TTT>TTA	p.F714L	NPHP1_uc002tfm.3_Missense_Mutation_p.F659L|NPHP1_uc002tfl.3_Missense_Mutation_p.F715L|NPHP1_uc002tfo.3_Missense_Mutation_p.F596L|NPHP1_uc010ywx.1_Missense_Mutation_p.F658L	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	714					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						CTGAAAGGTCAAAAGGTTCAT	0.502			NA											6	33					0	0	0.001168	0	0
MYO7B	4648	broad.mit.edu	37	2	128351172	128351172	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:128351172C>T	uc002top.2	+	18	2250	c.2197C>T	c.(2197-2199)CGG>TGG	p.R733W		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	733						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGTGTGGCTGCGGACAGACAA	0.607			NA											5	55					0	0	0.001168	0	0
LRP1B	53353	broad.mit.edu	37	2	141245256	141245256	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:141245256T>C	uc002tvj.1	-	58	10145	c.9173A>G	c.(9172-9174)TAT>TGT	p.Y3058C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3058	Extracellular (Potential).|LDL-receptor class B 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCGATCCAATAGATGAATTC	0.308	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			13	46					0	0	0.001855	0	0
LRP1B	53353	broad.mit.edu	37	2	141607683	141607683	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:141607683C>G	uc002tvj.1	-	29	5899	c.4927G>C	c.(4927-4929)GTT>CTT	p.V1643L	LRP1B_uc010fnl.1_Missense_Mutation_p.V825L	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1643	Extracellular (Potential).|LDL-receptor class B 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTGAAATAACAGTTTCTAAC	0.299	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			3	74					0	0	0.000248	0	0
LRP1B	53353	broad.mit.edu	37	2	141625694	141625694	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:141625694C>A	uc002tvj.1	-	26	5280	c.4308G>T	c.(4306-4308)GAG>GAT	p.E1436D	LRP1B_uc010fnl.1_Missense_Mutation_p.E618D	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1436	Extracellular (Potential).|LDL-receptor class B 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTATCCTTTTCTCAAAGTGGT	0.373	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			9	56					7.48243e-07	1.17892e-06	0.006214	1	0
PABPC1P2	728773	broad.mit.edu	37	2	147346327	147346327	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:147346327A>T	uc002twf.3	+	1	1703	c.787A>T	c.(787-789)AGA>TGA	p.R263*		NR_026904				RecName: Full=Putative protein PABPC1-like; AltName: Full=Polyadenylate-binding protein pseudogene 2;												0						TCAGAGTGTCAGACCTTATCC	0.522			NA											4	22					0	0	0.000248	0	0
GPD2	2820	broad.mit.edu	37	2	157436299	157436299	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:157436299A>T	uc002tzf.3	+	16	2417	c.2057A>T	c.(2056-2058)CAG>CTG	p.Q686L	GPD2_uc010zch.1_Missense_Mutation_p.Q459L|GPD2_uc002tzd.3_Missense_Mutation_p.Q686L|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	686	EF-hand 2.				cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						GAATTTTTGCAGGTGAGTTGT	0.313			NA											6	17					0	0	0.001984	0	0
FAP	2191	broad.mit.edu	37	2	163030285	163030285	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:163030285G>A	uc002ucd.2	-	23	2190	c.1982C>T	c.(1981-1983)ACA>ATA	p.T661I	FAP_uc010fpc.2_Missense_Mutation_p.T210I|FAP_uc010zct.1_Missense_Mutation_p.T636I|FAP_uc010fpd.2_Missense_Mutation_p.T140I	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	661	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GAATCTCTCTGTGTAGACAGA	0.313			NA											17	111					0	0	0.008871	0	0
XIRP2	129446	broad.mit.edu	37	2	168102148	168102148	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:168102148G>A	uc002udx.2	+	8	4264	c.4246G>A	c.(4246-4248)GGC>AGC	p.G1416S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G1241S|XIRP2_uc010fpq.2_Missense_Mutation_p.G1194S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1241	Xin 25.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TATACAAGGTGGCAATGTAAA	0.333			NA											10	24					0	0	0.006214	0	0
XIRP2	129446	broad.mit.edu	37	2	168103039	168103039	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:168103039G>A	uc002udx.2	+	8	5155	c.5137G>A	c.(5137-5139)GTC>ATC	p.V1713I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V1538I|XIRP2_uc010fpq.2_Missense_Mutation_p.V1491I|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1538					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGTGGTGATGTCAAACGTAC	0.338			NA											3	29					0	0	0.004672	0	0
TLK1	9874	broad.mit.edu	37	2	171910294	171910294	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:171910294C>A	uc002ugn.2	-	8	1181	c.709G>T	c.(709-711)GGA>TGA	p.G237*	TLK1_uc002ugo.2_Nonsense_Mutation_p.G258*|TLK1_uc002ugp.2_Nonsense_Mutation_p.G189*|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Nonsense_Mutation_p.G141*|TLK1_uc002ugr.1_Nonsense_Mutation_p.G20*	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	237	Potential.				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TCTATACGTCCCTCCTTCTTT	0.328			NA											36	121					7.62715e-32	1.53082e-31	0.007835	1	0
OLA1	29789	broad.mit.edu	37	2	175006616	175006616	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:175006616G>A	uc002uih.2	-	5	672	c.486C>T	c.(484-486)CCC>CCT	p.P162P	OLA1_uc002uii.2_Silent_p.P4P|OLA1_uc010fqq.2_Silent_p.P162P|OLA1_uc002uij.2_Silent_p.P4P|OLA1_uc002uik.2_Silent_p.P132P|OLA1_uc010fqr.2_Silent_p.P162P	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	162					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			ovary(1)|breast(1)	2						TATCTATAATGGGCCCAATCA	0.343			NA											6	48					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179577161	179577161	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:179577161G>T	uc010zfg.1	-	92	23980	c.23756C>A	c.(23755-23757)ACT>AAT	p.T7919N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T4580N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8846							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGATTTTTCAGTCGTAGTTAT	0.413			NA											5	77					0.000602214	0.000754262	0.000602	1	0
TTN	7273	broad.mit.edu	37	2	179585355	179585355	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:179585355C>G	uc010zfg.1	-	77	19626	c.19402G>C	c.(19402-19404)GGA>CGA	p.G6468R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G3129R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7395							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAAGAGCTCCTACTGGAGAA	0.383			NA											3	11					0	0	0.000248	0	0
TTN	7273	broad.mit.edu	37	2	179616755	179616755	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:179616755C>G	uc002unb.2	-	46	10596	c.10372G>C	c.(10372-10374)GAG>CAG	p.E3458Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	3463							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTCCCCCTCAGAGAATAAT	0.323			NA											8	98					0	0	0.004482	0	0
CCDC141	285025	broad.mit.edu	37	2	179742780	179742780	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:179742780C>A	uc002unf.1	-	2	142	c.85G>T	c.(85-87)GAC>TAC	p.D29Y	CCDC141_uc002ung.2_Missense_Mutation_p.D604Y	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	29							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TCAGCCGAGTCAGAACAATGC	0.373			NA											17	42					2.23348e-06	3.41486e-06	0.004007	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801377	185801377	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:185801377C>A	uc002uph.2	+	4	1848	c.1254C>A	c.(1252-1254)TGC>TGA	p.C418*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	418						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAAATTTCTGCAAAAGACAAT	0.378			NA											9	110					0.000274275	0.000355681	0.004482	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801697	185801697	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:185801697C>A	uc002uph.2	+	4	2168	c.1574C>A	c.(1573-1575)CCT>CAT	p.P525H		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	525						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAAGTCACTCCTCTTTTGGCT	0.373			NA											21	44					8.10497e-08	1.356e-07	0.001523	1	0
ZNF804A	91752	broad.mit.edu	37	2	185802923	185802923	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:185802923C>A	uc002uph.2	+	4	3394	c.2800C>A	c.(2800-2802)CTT>ATT	p.L934I		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	934						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAATACCCTGCTTGAACACAA	0.393			NA											5	60					3.59834e-05	5.08422e-05	0.001168	1	0
ZSWIM2	151112	broad.mit.edu	37	2	187694603	187694603	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:187694603C>A	uc002upu.1	-	8	986	c.946G>T	c.(946-948)GTT>TTT	p.V316F		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	316					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GGTGTGTAAACTTGGCTGAAT	0.368			NA											8	66					0.000673444	0.000838851	0.008291	1	0
COL3A1	1281	broad.mit.edu	37	2	189870985	189870985	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:189870985G>A	uc002uqj.1	+	42	3210	c.3093G>A	c.(3091-3093)AAG>AAA	p.K1031K		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1031	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGGTGGCAAGGTATAATAAA	0.368			NA											6	58					0	0	0.001984	0	0
COL3A1	1281	broad.mit.edu	37	2	189875573	189875573	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:189875573G>A	uc002uqj.1	+	50	4328	c.4211G>A	c.(4210-4212)GGA>GAA	p.G1404E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1404	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AAGGCTGAAGGAAATAGCAAA	0.408			NA											9	65					0	0	0.006214	0	0
COL5A2	1290	broad.mit.edu	37	2	189931133	189931133	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:189931133C>A	uc002uqk.2	-	23	1821	c.1546G>T	c.(1546-1548)GGG>TGG	p.G516W	COL5A2_uc010frx.2_Missense_Mutation_p.G92W	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	516					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCACTGGCCCTGGAGGACCA	0.463			NA											50	139					6.3008e-33	1.26685e-32	0.00361	1	0
Unknown	0	broad.mit.edu	37	2	190788268	190788268	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:190788268A>G	uc002uro.2	+	1	350	c.207A>G	c.(205-207)GGA>GGG	p.G69G						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;												NA						CTGTAGCAGGAGAGGATGGCA	0.478			NA											5	52					0	0	0.000602	0	0
MYO1B	4430	broad.mit.edu	37	2	192288585	192288585	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:192288585G>T	uc010fsg.2	+	31	3565	c.3310G>T	c.(3310-3312)GAC>TAC	p.D1104Y	MYO1B_uc002usq.2_Missense_Mutation_p.D1046Y|MYO1B_uc002usr.2_Missense_Mutation_p.D1104Y|MYO1B_uc002usu.2_Missense_Mutation_p.D349Y|MYO1B_uc002usv.2_Missense_Mutation_p.D220Y	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	1104						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GTTCAGACAGGACAAAGTATG	0.358			NA											29	68					0.00631998	0.00734099	0.00632	1	0
DNAH7	56171	broad.mit.edu	37	2	196729567	196729567	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:196729567C>A	uc002utj.3	-	41	6913	c.6812G>T	c.(6811-6813)TGT>TTT	p.C2271F		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2271					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGGAAATCACAAAACATTAA	0.378			NA											16	132					1.5739e-10	2.85159e-10	0.004007	1	0
SATB2	23314	broad.mit.edu	37	2	200137222	200137222	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:200137222C>A	uc002uuy.1	-	11	2731	c.1914G>T	c.(1912-1914)CTG>CTT	p.L638L	SATB2_uc010fsq.1_Silent_p.L520L|SATB2_uc002uuz.1_Silent_p.L638L|SATB2_uc002uva.1_Silent_p.L638L	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	638	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGTCTGGGTACAGGCCTACAT	0.527	Colon(30;262 767 11040 24421 36230)		NA											3	49					0.000602214	0.000754262	0.000602	1	0
MPP4	58538	broad.mit.edu	37	2	202550695	202550695	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:202550695C>A	uc002uyk.3	-	6	647	c.439G>T	c.(439-441)GAG>TAG	p.E147*	MPP4_uc010ftj.2_Nonsense_Mutation_p.E147*|MPP4_uc010zhq.1_Nonsense_Mutation_p.E147*|MPP4_uc010zhr.1_Nonsense_Mutation_p.E147*|MPP4_uc010zhs.1_Intron|MPP4_uc002uyj.3_Intron|MPP4_uc010zht.1_Nonsense_Mutation_p.E120*|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Nonsense_Mutation_p.E147*|MPP4_uc002uym.1_Intron|MPP4_uc002uyn.2_Intron	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	147						cytoplasm	protein binding				0						TCCTCACTCTCAGGGATATTG	0.453			NA											16	63					4.7546e-09	8.30958e-09	0.004007	1	0
FZD7	8324	broad.mit.edu	37	2	202899448	202899448	+	Silent	SNP	G	G	C	rs35732430	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:202899448G>C	uc002uyw.1	+	1	139	c.78G>C	c.(76-78)CTG>CTC	p.L26L		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	26					axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						TGGGCGCACTGTCCGCGGGCG	0.741			NA											13	26					0	0	0.00245	0	0
CYP20A1	57404	broad.mit.edu	37	2	204111546	204111546	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:204111546G>T	uc002uzv.3	+	3	813	c.191G>T	c.(190-192)AGA>ATA	p.R64I	CYP20A1_uc002uzx.3_Intron|CYP20A1_uc010zif.1_Missense_Mutation_p.R64I|CYP20A1_uc002uzy.3_Intron|CYP20A1_uc002uzw.3_RNA	NM_177538	NP_803882	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A,	64						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0						TTGCATGAGAGATATGGGCCT	0.428			NA											8	168					0.000274275	0.000355681	0.004482	1	0
PARD3B	117583	broad.mit.edu	37	2	206480373	206480373	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:206480373A>T	uc002var.1	+	23	3661	c.3454A>T	c.(3454-3456)AAA>TAA	p.K1152*	PARD3B_uc002vao.1_Nonsense_Mutation_p.K1051*|PARD3B_uc002vap.1_Nonsense_Mutation_p.K1090*|PARD3B_uc002vaq.1_Nonsense_Mutation_p.K1083*|uc010fuc.1_5'Flank	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	1152					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TCCCCAGCACAAAGGACCCTT	0.637			NA											6	48					0	0	0.001984	0	0
NDUFS1	4719	broad.mit.edu	37	2	206991267	206991267	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:206991267C>A	uc002vbe.2	-	18	2215	c.2088G>T	c.(2086-2088)ATG>ATT	p.M696I	NDUFS1_uc010ziq.1_Missense_Mutation_p.M710I|NDUFS1_uc010zir.1_Missense_Mutation_p.M660I|NDUFS1_uc010zis.1_Missense_Mutation_p.M639I|NDUFS1_uc010zit.1_Missense_Mutation_p.M585I|NDUFS1_uc010ziu.1_Missense_Mutation_p.M580I	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	696					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	ACATACCTGTCATGTAGAAGT	0.368			NA											3	22					6.4e-05	8.8683e-05	0.004672	1	0
ZDBF2	57683	broad.mit.edu	37	2	207171384	207171384	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:207171384C>T	uc002vbp.2	+	5	2382	c.2132C>T	c.(2131-2133)CCG>CTG	p.P711L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	711							nucleic acid binding|zinc ion binding			ovary(3)	3						TCTGATTCTCCGGCTTCTCTT	0.408			NA											10	34					0	0	0.006214	0	0
CPS1	1373	broad.mit.edu	37	2	211438024	211438024	+	Silent	SNP	A	A	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:211438024A>C	uc002vee.3	+	2	261	c.129A>C	c.(127-129)GCA>GCC	p.A43A	CPS1_uc010fur.2_Silent_p.A49A	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	43	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCTTCAGGCACAGACAGCAC	0.383			NA											7	97					0	0	0.004482	0	0
CPS1	1373	broad.mit.edu	37	2	211525277	211525277	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:211525277C>T	uc002vee.3	+	32	3957	c.3825C>T	c.(3823-3825)TTC>TTT	p.F1275F	CPS1_uc010fur.2_Silent_p.F1281F|CPS1_uc010fus.2_Silent_p.F824F	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1275	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GGGTTGACTTCATTGATGTGG	0.413			NA											7	137					0	0	0.001984	0	0
ERBB4	2066	broad.mit.edu	37	2	212251683	212251683	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:212251683G>A	uc002veg.1	-	27	3474	c.3376C>T	c.(3376-3378)CAG>TAG	p.Q1126*	ERBB4_uc002veh.1_Nonsense_Mutation_p.Q1110*|ERBB4_uc010zji.1_Nonsense_Mutation_p.Q1116*|ERBB4_uc010zjj.1_Nonsense_Mutation_p.Q1100*	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1126	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CTGTACCTCTGGGTGCTACTG	0.557			NA								TSP Lung(8;0.080)			7	75					0	0	0.00308	0	0
BARD1	580	broad.mit.edu	37	2	215645838	215645838	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:215645838T>A	uc002veu.2	-	4	895	c.760A>T	c.(760-762)ATA>TTA	p.I254L	BARD1_uc010zjm.1_Missense_Mutation_p.I110L	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	254					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCACCATTTATCTGAGGACTG	0.398			NA							Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				17	57					0	0	0.004007	0	0
TNS1	7145	broad.mit.edu	37	2	218700935	218700935	+	Splice_Site	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:218700935C>G	uc002vgt.2	-	18	3031	c.2633_splice	c.e18-1	p.G878_splice	TNS1_uc002vgr.2_Splice_Site_p.G878_splice|TNS1_uc002vgs.2_Splice_Site_p.G878_splice|TNS1_uc010zjv.1_Splice_Site_p.G878_splice	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin							cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GCCTGTACCCCTGGGAGGAAA	0.572			NA											5	35					0	0	0.000602	0	0
SPEG	10290	broad.mit.edu	37	2	220350089	220350089	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:220350089G>T	uc010fwg.2	+	31	7631	c.7631G>T	c.(7630-7632)CGG>CTG	p.R2544L		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2544					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGCCGAAGCCGGCTCCGCTGG	0.622			NA											7	75					0.000157383	0.000211083	0.00308	1	0
SLC4A3	6508	broad.mit.edu	37	2	220505177	220505177	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:220505177G>C	uc002vmp.3	+	21	3572	c.3303G>C	c.(3301-3303)GTG>GTC	p.V1101V	SLC4A3_uc002vmo.3_Silent_p.V1128V|SLC4A3_uc010fwm.2_Silent_p.V651V	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	1101	Helical; (Potential).|Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGGGGCTGTGCTGCGTCGGA	0.607			NA											6	72					0	0	0.001984	0	0
IRS1	3667	broad.mit.edu	37	2	227661390	227661390	+	Missense_Mutation	SNP	C	C	A	rs141094678	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:227661390C>A	uc002voh.3	-	1	2117	c.2065G>T	c.(2065-2067)GTC>TTC	p.V689F		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	689					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CCGGAAGGGACGGCGTtgctg	0.552			NA									OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	50					3.62473e-10	6.49479e-10	0.001882	1	0
TRIP12	9320	broad.mit.edu	37	2	230657800	230657800	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:230657800G>A	uc002vpw.1	-	26	3914	c.3805C>T	c.(3805-3807)CAG>TAG	p.Q1269*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.Q1317*|TRIP12_uc002vpy.1_Nonsense_Mutation_p.Q999*	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1269					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CTTTGTAACTGGCATTTTAAT	0.388			NA											4	48					0	0	0.000602	0	0
CHRND	1144	broad.mit.edu	37	2	233398755	233398755	+	Nonsense_Mutation	SNP	G	G	T	rs145920855		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:233398755G>T	uc002vsw.2	+	10	1166	c.1162G>T	c.(1162-1164)GAG>TAG	p.E388*	CHRND_uc010zmg.1_Nonsense_Mutation_p.E373*|CHRND_uc010fyc.2_Nonsense_Mutation_p.E261*|CHRND_uc010zmh.1_Nonsense_Mutation_p.E194*	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	388	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CTCCAAGGCCGAGGAGTACTT	0.662			NA											9	74					1.76689e-08	3.00478e-08	0.006214	1	0
UGT1A7	54577	broad.mit.edu	37	2	234591014	234591014	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:234591014C>G	uc002vut.2	+	1	431	c.431C>G	c.(430-432)GCA>GGA	p.A144G	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Missense_Mutation_p.A144G	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	144					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TGTTTTGATGCAGTGTTTCTC	0.373			NA											14	109					0	0	0.001855	0	0
ASB18	401036	broad.mit.edu	37	2	237172946	237172946	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:237172946C>G	uc010znh.1	-	1	43	c.43G>C	c.(43-45)GAT>CAT	p.D15H		NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	15					intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		TTCACTAAATCTGAGTTGAGT	0.468			NA											5	53					0	0	0.001984	0	0
COL6A3	1293	broad.mit.edu	37	2	238253293	238253293	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:238253293C>T	uc002vwl.2	-	36	7653	c.7368G>A	c.(7366-7368)ACG>ACA	p.T2456T	COL6A3_uc002vwo.2_Silent_p.T2250T|COL6A3_uc010znj.1_Silent_p.T1849T|COL6A3_uc002vwj.2_5'Flank|COL6A3_uc002vwp.1_Silent_p.T277T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2456	VWFA 11.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACCGGATCTCCGTGGTCACCT	0.547			NA											6	64					0	0	0.001168	0	0
PER2	8864	broad.mit.edu	37	2	239161618	239161618	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr2:239161618C>T	uc002vyc.2	-	19	3283	c.3046G>A	c.(3046-3048)GCA>ACA	p.A1016T	PER2_uc010znv.1_Missense_Mutation_p.A1016T	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	1016					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		CCTACAGCTGCTGTCTCTGTG	0.637			NA											13	73					0	0	0.00245	0	0
ZNF343	79175	broad.mit.edu	37	20	2464827	2464827	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:2464827C>A	uc002wge.1	-	6	1268	c.780G>T	c.(778-780)CCG>CCT	p.P260P	ZNF343_uc010gao.1_Silent_p.P260P|ZNF343_uc002wgd.1_Silent_p.P170P	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AGAGGGTCCTCGGGTTTGTAA	0.433			NA											5	61					0.00116845	0.00142726	0.001168	1	0
RASSF2	9770	broad.mit.edu	37	20	4778672	4778672	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:4778672T>A	uc002wld.2	-	3	173	c.119A>T	c.(118-120)CAG>CTG	p.Q40L	RASSF2_uc002wlc.2_5'Flank|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.Q40L	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	40					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						GTGCCGGAGCTGTAAATTCTG	0.502	Melanoma(158;1891 3343 50738)		NA											6	25					0	0	0.001168	0	0
PROKR2	128674	broad.mit.edu	37	20	5283320	5283320	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:5283320A>T	uc010zqw.1	-	2	521	c.521T>A	c.(520-522)ATC>AAC	p.I174N	PROKR2_uc010zqx.1_Missense_Mutation_p.I174N|PROKR2_uc010zqy.1_Missense_Mutation_p.I174N	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	174	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GACCAAGGCGATCAGGAAGGA	0.488			NA								HNSCC(71;0.22)			7	94					0	0	0.00308	0	0
MCM8	84515	broad.mit.edu	37	20	5966774	5966774	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:5966774A>T	uc002wmi.2	+	16	2537	c.2160A>T	c.(2158-2160)ACA>ACT	p.T720T	MCM8_uc002wmj.2_Silent_p.T704T|MCM8_uc002wmk.2_Silent_p.T760T|MCM8_uc002wml.2_Silent_p.T720T|MCM8_uc010gbp.2_Silent_p.T673T|MCM8_uc002wmm.2_Silent_p.T258T	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	720					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						TTCGTCTGACAGAGGTTTGTT	0.408			NA											4	37					0	0	0.000248	0	0
TTLL9	164395	broad.mit.edu	37	20	30512840	30512840	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:30512840G>A	uc010gdx.1	+	9	946	c.693G>A	c.(691-693)GTG>GTA	p.V231V	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Silent_p.V118V|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	231	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GTGTCTATGTGCTGGTGATGT	0.433			NA											4	23					0	0	0.000602	0	0
PLUNC	51297	broad.mit.edu	37	20	31828099	31828099	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:31828099C>G	uc002wyv.2	+	5	559	c.489C>G	c.(487-489)ATC>ATG	p.I163M	PLUNC_uc002wyt.3_Missense_Mutation_p.I163M|PLUNC_uc002wyu.3_Missense_Mutation_p.I163M	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	163					innate immune response	extracellular region	lipid binding				0						CTGCAGAAATCTTAGCTGTGA	0.557			NA											36	132					0	0	0.004289	0	0
AHCY	191	broad.mit.edu	37	20	32873372	32873372	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:32873372C>T	uc002xai.2	-	9	1180	c.1041G>A	c.(1039-1041)CTG>CTA	p.L347L	AHCY_uc002xaj.2_Silent_p.L319L	NM_000687	NP_000678	P23526	SAHH_HUMAN	adenosylhomocysteinase isoform 1	347					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding				0						TGGCACAACCCAGGTTGACCA	0.612			NA											12	38					0	0	0.00245	0	0
DLGAP4	22839	broad.mit.edu	37	20	35061089	35061089	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:35061089C>G	uc002xff.2	+	3	1404	c.969C>G	c.(967-969)TGC>TGG	p.C323W	DLGAP4_uc010zvp.1_Missense_Mutation_p.C323W	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	323					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCAAATCCTGCCACCAGGGTC	0.612			NA											4	14					0	0	0.000248	0	0
C20orf132	140699	broad.mit.edu	37	20	35748921	35748921	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:35748921C>G	uc010zvu.1	-	19	2336	c.2245G>C	c.(2245-2247)GGC>CGC	p.G749R	C20orf132_uc002xgk.2_Missense_Mutation_p.G371R	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)				ACAAAAAAGCCTGCAGATGTG	0.443			NA											4	12					0	0	0.001984	0	0
RPN2	6185	broad.mit.edu	37	20	35832307	35832307	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:35832307A>G	uc002xgp.2	+	5	803	c.499A>G	c.(499-501)ACA>GCA	p.T167A	RPN2_uc002xgo.3_Missense_Mutation_p.T167A|RPN2_uc010gfw.2_Missense_Mutation_p.T10A|RPN2_uc002xgq.2_Missense_Mutation_p.T135A	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	167	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GGCTCTGCAGACAGCATCCCA	0.512			NA											6	24					0	0	0.00308	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356650	37356650	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:37356650A>T	uc002xjc.2	+	2	1209	c.946A>T	c.(946-948)AGC>TGC	p.S316C		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	316	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CATCGTGTTCAGCTACACGTC	0.567			NA											4	32					0	0	0.001168	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37529274	37529274	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:37529274T>A	uc002xje.2	+	5	707	c.518T>A	c.(517-519)CTC>CAC	p.L173H	PPP1R16B_uc010ggc.2_Missense_Mutation_p.L173H	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	173					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CCATATGACCTCTGCGAGGAT	0.572			NA											5	38					0	0	0.001168	0	0
KCNK15	60598	broad.mit.edu	37	20	43379220	43379220	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:43379220G>T	uc002xmr.2	+	2	798	c.734G>T	c.(733-735)CGC>CTC	p.R245L		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	245	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				GTGGTCCTGCGCTTCCTCGTT	0.607			NA											5	48					8.12818e-05	0.000110582	0.001984	1	0
PIGT	51604	broad.mit.edu	37	20	44048032	44048032	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:44048032C>T	uc002xoh.1	+	4	664	c.591C>T	c.(589-591)TCC>TCT	p.S197S	PIGT_uc010ghb.1_Silent_p.S187S|PIGT_uc010zwt.1_RNA|PIGT_uc010ghd.1_Intron|PIGT_uc010ghc.1_Intron|PIGT_uc010ghe.1_Silent_p.S160S|PIGT_uc010ghf.1_Intron|PIGT_uc002xoj.1_Silent_p.S197S|PIGT_uc002xok.1_Intron|PIGT_uc010zwu.1_5'UTR|PIGT_uc002xoi.1_RNA|PIGT_uc010zwv.1_5'UTR|PIGT_uc010zww.1_Silent_p.S141S|PIGT_uc010zwx.1_Intron|PIGT_uc010zwy.1_Silent_p.S95S|PIGT_uc010zwz.1_Intron|PIGT_uc010zxa.1_Missense_Mutation_p.P25L|PIGT_uc002xol.1_Silent_p.S53S|PIGT_uc010zxb.1_5'Flank	NM_015937	NP_057021	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	197	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				CCTGTAGTTCCAAGGTGAGGC	0.602			NA											4	37					0	0	0.000248	0	0
SLC12A5	57468	broad.mit.edu	37	20	44663650	44663650	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:44663650A>T	uc010zxl.1	+	2	261	c.185A>T	c.(184-186)GAG>GTG	p.E62V	SLC12A5_uc002xra.2_Missense_Mutation_p.E39V|SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.E39V	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	62	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAGGGAAAGGAGTATGATGGC	0.532			NA											7	53					0	0	0.00308	0	0
ZNF334	55713	broad.mit.edu	37	20	45130108	45130108	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:45130108C>A	uc002xsc.2	-	5	2054	c.1870G>T	c.(1870-1872)GGA>TGA	p.G624*	ZNF334_uc002xsa.2_Nonsense_Mutation_p.G647*|ZNF334_uc002xsb.2_Nonsense_Mutation_p.G586*|ZNF334_uc002xsd.2_Nonsense_Mutation_p.G586*|ZNF334_uc010ghl.2_Nonsense_Mutation_p.G623*	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	624					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				GGTTTCTCTCCTGTGTGAATT	0.428			NA											13	74					1.5842e-08	2.71441e-08	0.001855	1	0
TSHZ2	128553	broad.mit.edu	37	20	51871053	51871053	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:51871053G>T	uc002xwo.2	+	2	2012	c.1056G>T	c.(1054-1056)TTG>TTT	p.L352F		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	352					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			ACGCCAACTTGCAGTTGTCCT	0.493			NA											3	91					3.59834e-05	5.08422e-05	0.001168	1	0
TSHZ2	128553	broad.mit.edu	37	20	51872417	51872417	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:51872417C>T	uc002xwo.2	+	2	3376	c.2420C>T	c.(2419-2421)ACC>ATC	p.T807I		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	807					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AAAGCCACCACCCCAAAGCCA	0.547			NA											19	50					0	0	0.006122	0	0
ZNF217	7764	broad.mit.edu	37	20	52198754	52198754	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:52198754C>A	uc002xwq.3	-	1	883	c.612G>T	c.(610-612)CAG>CAT	p.Q204H	ZNF217_uc010gij.1_Missense_Mutation_p.Q196H	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	204					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CCGCGTGCACCTGGACGACCT	0.493			NA											10	149					2.17888e-05	3.14511e-05	0.006214	1	0
CYP24A1	1591	broad.mit.edu	37	20	52782353	52782353	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:52782353A>T	uc002xwv.2	-	5	1058	c.660T>A	c.(658-660)TAT>TAA	p.Y220*	CYP24A1_uc002xwu.1_Nonsense_Mutation_p.Y78*|CYP24A1_uc002xww.2_Nonsense_Mutation_p.Y220*	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	220					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	ATCTCTTCTCATACAACACGA	0.403			NA											5	54					0	0	0.000602	0	0
MC3R	4159	broad.mit.edu	37	20	54824621	54824621	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:54824621C>T	uc002xxb.2	+	1	834	c.722C>T	c.(721-723)GCA>GTA	p.A241V		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	278	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			ATGAAGGGGGCAGTCACCATC	0.612			NA											6	60					0	0	0.001168	0	0
CTCFL	140690	broad.mit.edu	37	20	56098207	56098207	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:56098207A>T	uc010gix.1	-	2	1333	c.671T>A	c.(670-672)GTG>GAG	p.V224E	CTCFL_uc010giw.1_Missense_Mutation_p.V224E|CTCFL_uc002xym.2_Missense_Mutation_p.V224E|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Missense_Mutation_p.V224E|CTCFL_uc010gjb.1_Missense_Mutation_p.V224E|CTCFL_uc010gjc.1_Missense_Mutation_p.V224E|CTCFL_uc010gjd.1_Missense_Mutation_p.V224E|CTCFL_uc010gje.2_Missense_Mutation_p.V224E|CTCFL_uc010gjf.2_Missense_Mutation_p.V19E|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Missense_Mutation_p.V224E|CTCFL_uc010gji.1_Missense_Mutation_p.V19E|CTCFL_uc010gjj.1_Missense_Mutation_p.V224E|CTCFL_uc010gjk.1_Missense_Mutation_p.V224E|CTCFL_uc010gjl.1_Missense_Mutation_p.V224E	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	224					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			TTGTTCTTCCACATTTGAATT	0.393			NA											19	147					0	0	0.001523	0	0
PCK1	5105	broad.mit.edu	37	20	56138123	56138123	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:56138123C>A	uc002xyn.3	+	5	813	c.650C>A	c.(649-651)ACG>AAG	p.T217K	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	217					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCGGAGCTGACGCTCATCGCC	0.627			NA											9	74					1.12685e-05	1.66247e-05	0.004482	1	0
ZNF831	128611	broad.mit.edu	37	20	57766799	57766799	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:57766799C>T	uc002yan.2	+	1	725	c.725C>T	c.(724-726)TCG>TTG	p.S242L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	242						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GAAGGCGCCTCGGAGAGACCC	0.687			NA											6	67					0	0	0.001168	0	0
PHACTR3	116154	broad.mit.edu	37	20	58348388	58348388	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:58348388G>T	uc002yau.2	+	6	1273	c.806G>T	c.(805-807)CGG>CTG	p.R269L	PHACTR3_uc002yat.2_Missense_Mutation_p.R266L|PHACTR3_uc010zzw.1_Missense_Mutation_p.R228L|PHACTR3_uc002yav.2_Missense_Mutation_p.R228L|PHACTR3_uc002yaw.2_Missense_Mutation_p.R228L|PHACTR3_uc002yax.2_Missense_Mutation_p.R158L	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	269						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CCTTCCCTCCGGGGCCAGCTC	0.647			NA											4	96					0.00116845	0.00142726	0.001168	1	0
OPRL1	4987	broad.mit.edu	37	20	62724200	62724200	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:62724200G>T	uc002yic.2	+	3	529	c.127G>T	c.(127-129)GGC>TGC	p.G43C	OPRL1_uc002yid.2_Missense_Mutation_p.G43C|OPRL1_uc002yif.3_Missense_Mutation_p.G43C	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	43	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TGCCAGCCACGGCGCCTTCCT	0.637			NA											5	125					0.00116845	0.00142726	0.001168	1	0
TPTE	7179	broad.mit.edu	37	21	10933919	10933919	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr21:10933919C>A	uc002yip.1	-	17	1328	c.960G>T	c.(958-960)AAG>AAT	p.K320N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.K302N|TPTE_uc002yir.1_Missense_Mutation_p.K282N|TPTE_uc010gkv.1_Missense_Mutation_p.K182N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	320	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATTTACTTCCTTGGTGAAAA	0.338			NA											24	297					3.73988e-18	7.32501e-18	0.00632	1	0
HSPA13	6782	broad.mit.edu	37	21	15750613	15750613	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr21:15750613G>A	uc002yjt.2	-	3	556	c.487C>T	c.(487-489)CTT>TTT	p.L163F	HSPA13_uc011abx.1_Intron	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	163						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						GGCATTCCAAGATATGCCTCT	0.413			NA											6	35					0	0	0.001168	0	0
NCAM2	4685	broad.mit.edu	37	21	22656612	22656612	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr21:22656612C>G	uc002yld.1	+	3	478	c.229C>G	c.(229-231)CGG>GGG	p.R77G	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.R102G	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	77	Ig-like C2-type 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TGTTAGGTCACGGTTAACCAT	0.398			NA											3	36					0	0	0.004672	0	0
NCAM2	4685	broad.mit.edu	37	21	22841100	22841100	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr21:22841100G>A	uc002yld.1	+	14	2141	c.1892G>A	c.(1891-1893)AGA>AAA	p.R631K	NCAM2_uc011acb.1_Missense_Mutation_p.R489K	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	631	Fibronectin type-III 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GTGAAATATAGAAGTGTAAGT	0.363			NA											3	30					0	0	0.004672	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28306945	28306945	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr21:28306945C>A	uc002ymg.2	-	4	2258	c.1529G>T	c.(1528-1530)GGC>GTC	p.G510V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	510	Disintegrin.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GACATCCATGCCGGGACACAC	0.612	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											8	32					0.000157383	0.000211083	0.00308	1	0
ABCG1	9619	broad.mit.edu	37	21	43645891	43645891	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr21:43645891A>T	uc002zaq.2	+	2	259	c.153A>T	c.(151-153)GGA>GGT	p.G51G	ABCG1_uc002zan.2_Silent_p.G53G|ABCG1_uc002zam.2_Silent_p.G29G|ABCG1_uc002zao.2_Silent_p.G48G|ABCG1_uc002zap.2_Silent_p.G51G|ABCG1_uc002zar.2_Silent_p.G62G|ABCG1_uc011aev.1_Silent_p.G62G	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	51	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	TGCTGAATGGACATCTGAAAA	0.527			NA											9	64					0	0	0.004482	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072912	17072913	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:17072912_17072913TG>AT	uc002zlp.1	-	1	788_789	c.528_529CA>AT	c.(526-531)CCCATG>CCATTG	p.M177L		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	177					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AAGTGGTCCATGGGGGACAGGG	0.619			NA											13	45					0	0	0.004672	0	0
C22orf31	25770	broad.mit.edu	37	22	29456675	29456675	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:29456675G>T	uc003aej.1	-	2	287	c.160C>A	c.(160-162)CCA>ACA	p.P54T		NM_015370	NP_056185	O95567	CV031_HUMAN	hypothetical protein LOC25770	54											0						GCTGGTGCTGGGGCATTAATG	0.483			NA											9	62					1.12685e-05	1.66247e-05	0.004482	1	0
RNF215	200312	broad.mit.edu	37	22	30782716	30782716	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:30782716T>A	uc003ahp.2	-	2	318	c.318A>T	c.(316-318)CCA>CCT	p.P106P	RNF215_uc011akw.1_Silent_p.P11P	NM_001017981	NP_001017981	Q9Y6U7	RN215_HUMAN	ring finger protein 215	106	Extracellular (Potential).					integral to membrane	zinc ion binding			central_nervous_system(1)	1						AGCCTTCCACTGGTGCCTCCT	0.642			NA											9	42					0	0	0.000978	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30951023	30951023	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:30951023C>A	uc003aig.1	-	4	1329	c.1189G>T	c.(1189-1191)GAG>TAG	p.E397*	GAL3ST1_uc003aih.1_Nonsense_Mutation_p.E397*|GAL3ST1_uc003aii.1_Nonsense_Mutation_p.E397*|GAL3ST1_uc010gvz.1_Nonsense_Mutation_p.E397*	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	397	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						TACTGGATCTCGGGCGTGAGC	0.652			NA											9	44					0.00448238	0.00529312	0.004482	1	0
PATZ1	23598	broad.mit.edu	37	22	31722987	31722987	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:31722987T>A	uc003akq.2	-	5	2615	c.1954A>T	c.(1954-1956)AAC>TAC	p.N652Y	PATZ1_uc003akp.2_3'UTR|PATZ1_uc003akr.2_Missense_Mutation_p.N606Y	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	652					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						AGAGACATGTTCTGCTGAGGA	0.567			NA											6	53					0	0	0.001984	0	0
IL2RB	3560	broad.mit.edu	37	22	37524495	37524495	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:37524495T>G	uc003aqv.1	-	10	1428	c.1297A>C	c.(1297-1299)AGT>CGT	p.S433R		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	433	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	CCGAGGAGACTGGGGGAGAAG	0.657			NA											3	10					0	0	0.004672	0	0
GRAP2	9402	broad.mit.edu	37	22	40367050	40367050	+	Missense_Mutation	SNP	C	C	T	rs12759		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:40367050C>T	uc003ayh.1	+	8	1218	c.955C>T	c.(955-957)CTC>TTC	p.L319F	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Missense_Mutation_p.L293F|GRAP2_uc011aon.1_Missense_Mutation_p.L253F|GRAP2_uc010gya.1_Missense_Mutation_p.L319F|GRAP2_uc011aoo.1_Missense_Mutation_p.L247F|GRAP2_uc011aop.1_Missense_Mutation_p.L279F|GRAP2_uc011aoq.1_Missense_Mutation_p.L206F|GRAP2_uc003ayj.1_Missense_Mutation_p.L319F	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	319	SH3 2.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						CAAGCTGGGCCTCTTCCCTGC	0.587			NA											4	63					0	0	0.001168	0	0
NFAM1	150372	broad.mit.edu	37	22	42783046	42783046	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:42783046G>C	uc003bcn.3	-	5	740	c.702C>G	c.(700-702)ATC>ATG	p.I234M		NM_145912	NP_666017	Q8NET5	NFAM1_HUMAN	NFAT activation molecule 1 precursor	234	Cytoplasmic (Potential).|ITAM.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity				0						CCTCATTCTCGATGCAGGCAT	0.647			NA											8	61					0	0	0.004482	0	0
PHF21B	112885	broad.mit.edu	37	22	45312390	45312390	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:45312390C>A	uc003bfn.2	-	4	485	c.334G>T	c.(334-336)GCC>TCC	p.A112S	PHF21B_uc003bfm.2_5'UTR|PHF21B_uc011aqk.1_Missense_Mutation_p.A100S|PHF21B_uc011aql.1_Missense_Mutation_p.A112S|PHF21B_uc011aqm.1_Missense_Mutation_p.A100S	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	112							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GTGGGGAGGGCTGGGCTGGGG	0.721			NA											8	55					1.26484e-09	2.23115e-09	0.00308	1	0
FBLN1	2192	broad.mit.edu	37	22	45929024	45929024	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:45929024C>G	uc003bgj.1	+	6	773	c.626C>G	c.(625-627)TCT>TGT	p.S209C	FBLN1_uc003bgg.1_Missense_Mutation_p.S209C|FBLN1_uc003bgh.2_Missense_Mutation_p.S209C|FBLN1_uc010gzz.2_Missense_Mutation_p.S247C|FBLN1_uc003bgi.1_Missense_Mutation_p.S209C	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	209	EGF-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CAGCTGCTGTCTGATGGTGTC	0.627			NA											3	46					0	0	0.004672	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659383	50659383	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr22:50659383C>A	uc003bkb.1	-	16	3917	c.3405G>T	c.(3403-3405)GGG>GGT	p.G1135G	TUBGCP6_uc003bka.1_Silent_p.G222G|TUBGCP6_uc010har.1_Silent_p.G1127G|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1135	9 X 27 AA tandem repeats.|5.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGGACACGTGCCCGTGGGTAT	0.627			NA											23	121					2.89027e-11	5.32147e-11	0.002299	1	0
CHL1	10752	broad.mit.edu	37	3	424236	424236	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:424236C>T	uc003bou.2	+	17	2281	c.2010C>T	c.(2008-2010)ACC>ACT	p.T670T	CHL1_uc003bot.2_Silent_p.T686T|CHL1_uc003bow.1_Silent_p.T670T|CHL1_uc011asi.1_Silent_p.T686T|uc003box.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	670	Fibronectin type-III 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GAAAGAAAACCACAGTTATCT	0.458			NA											6	58					0	0	0.001168	0	0
METTL6	131965	broad.mit.edu	37	3	15457374	15457374	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:15457374C>A	uc003bzs.1	-	4	694	c.436G>T	c.(436-438)GTA>TTA	p.V146L	METTL6_uc011avp.1_Missense_Mutation_p.V101L|METTL6_uc003bzt.1_Missense_Mutation_p.V146L|METTL6_uc010hen.1_5'Flank	NM_152396	NP_689609	Q8TCB7	METL6_HUMAN	methyltransferase like 6	146							methyltransferase activity				0						TCTGGCGGTACATGATCCAGA	0.383			NA											4	61					0.00024832	0.000325365	0.000248	1	0
DLEC1	9940	broad.mit.edu	37	3	38126765	38126766	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:38126765_38126766GG>TT	uc003cho.1	+	8	1283_1284	c.1262_1263GG>TT	c.(1261-1263)GGG>GTT	p.G421V	DLEC1_uc003chp.1_Missense_Mutation_p.G421V|DLEC1_uc010hgv.1_Missense_Mutation_p.G421V|DLEC1_uc010hgw.1_Intron|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	421					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		TCATGCACAGGGATGTTCCCAG	0.535			NA											4	70					0	0	0.004672	0	0
ABHD5	51099	broad.mit.edu	37	3	43744035	43744035	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:43744035A>G	uc003cmx.2	+	3	572	c.462A>G	c.(460-462)CTA>CTG	p.L154L		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	154					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		GGCACAACCTAGGTGGATTCT	0.468			NA											4	84					0	0	0.000248	0	0
CDCP1	64866	broad.mit.edu	37	3	45153697	45153697	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:45153697C>A	uc003com.2	-	3	668	c.533G>T	c.(532-534)TGC>TTC	p.C178F	CDCP1_uc003con.2_Missense_Mutation_p.C178F	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	178	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GCCATTGCTGCAGAAGGTTCC	0.577			NA											4	83					0.00024832	0.000325365	0.000248	1	0
PLXNB1	5364	broad.mit.edu	37	3	48465380	48465380	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:48465380T>A	uc003csw.2	-	3	911	c.641A>T	c.(640-642)TAC>TTC	p.Y214F	PLXNB1_uc003csu.2_Missense_Mutation_p.Y214F|PLXNB1_uc003csx.2_Missense_Mutation_p.Y214F|PLXNB1_uc010hjx.1_RNA	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	214	Extracellular (Potential).|Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGGTGGCTGTACTCGGAGAG	0.632			NA											4	18					0	0	0.000248	0	0
COL7A1	1294	broad.mit.edu	37	3	48619147	48619147	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:48619147C>A	uc003ctz.2	-	48	4715	c.4714G>T	c.(4714-4716)GGG>TGG	p.G1572W	MIR711_hsa-mir-711|MI0012488_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1572	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACCCGTTCCCCTTGGACTCCG	0.587			NA											7	90					0.00198382	0.00238984	0.001984	1	0
UQCRC1	7384	broad.mit.edu	37	3	48637934	48637934	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:48637934G>A	uc003cub.1	-	10	1239	c.1194C>T	c.(1192-1194)GCC>GCT	p.A398A	UQCRC1_uc003cua.1_Silent_p.A283A|UQCRC1_uc003cuc.1_Silent_p.A399A|UQCRC1_uc003cud.1_Silent_p.A397A	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	398					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	GAGATACCAGGGCATTTCTGA	0.562	NSCLC(81;1112 1427 27031 32409 45529)		NA											3	37					0	0	0.000248	0	0
RBM6	10180	broad.mit.edu	37	3	50103766	50103767	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:50103766_50103767CC>TT	uc003cyc.2	+	17	2907_2908	c.2774_2775CC>TT	c.(2773-2775)CCC>CTT	p.P925L	RBM6_uc010hlc.1_3'UTR|RBM6_uc003cyd.2_Missense_Mutation_p.P403L|RBM6_uc003cye.2_Missense_Mutation_p.P403L|RBM6_uc011bdi.1_Missense_Mutation_p.P267L|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	925					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		CAGACCCCTCCCCCACAGCCCC	0.53			NA											4	27					0	0	0.004672	0	0
HYAL3	8372	broad.mit.edu	37	3	50332756	50332756	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:50332756C>A	uc003czd.1	-	2	551	c.278G>T	c.(277-279)GGG>GTG	p.G93V	HYAL3_uc003czc.1_Missense_Mutation_p.G93V|HYAL3_uc003cze.1_Intron|HYAL3_uc003czf.1_Intron|HYAL3_uc003czg.1_Missense_Mutation_p.G93V	NM_003549	NP_003540	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3 precursor	93					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGGGATGCCCCCATTGTGAGC	0.587			NA											17	82					1.67942e-08	2.87322e-08	0.006122	1	0
CNTN3	5067	broad.mit.edu	37	3	74411047	74411047	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:74411047T>A	uc003dpm.1	-	10	1438	c.1358A>T	c.(1357-1359)CAT>CTT	p.H453L		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	453	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ATACCTTTCATGCTCCTGCAC	0.458			NA											3	42					0	0	0.004672	0	0
PROS1	5627	broad.mit.edu	37	3	93611874	93611874	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:93611874G>T	uc003drb.3	-	10	1399	c.1058C>A	c.(1057-1059)GCA>GAA	p.A353E	PROS1_uc010hoo.2_Missense_Mutation_p.A222E|PROS1_uc003dqz.3_Missense_Mutation_p.A222E	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	353	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ACCACGAAGTGCAATCAGGAG	0.388			NA											8	51					3.09899e-07	4.96537e-07	0.004482	1	0
PROS1	5627	broad.mit.edu	37	3	93624698	93624698	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:93624698A>G	uc003drb.3	-	6	872	c.531T>C	c.(529-531)AAT>AAC	p.N177N	PROS1_uc010hoo.2_Silent_p.N46N|PROS1_uc003dqz.3_Silent_p.N46N	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	177	EGF-like 2; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTCCAGGTGTATTATCACAAA	0.284			NA											7	69					0	0	0.00308	0	0
GPR15	2838	broad.mit.edu	37	3	98251619	98251619	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:98251619G>A	uc011bgy.1	+	1	742	c.742G>A	c.(742-744)GCA>ACA	p.A248T		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	248	Helical; Name=6; (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TATTGTCGTGGCAGCCTTTCT	0.443			NA											12	45					0	0	0.001855	0	0
GPR128	84873	broad.mit.edu	37	3	100362478	100362478	+	Splice_Site	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:100362478G>T	uc003duc.2	+	8	1214	c.946_splice	c.e8+1	p.N316_splice	GPR128_uc011bhc.1_Intron	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						ATGACGAAAAGTAAGTCTCAA	0.333	Pancreas(87;185 1975 7223 18722)		NA											6	23					0.00116845	0.00142726	0.001168	1	0
CCDC54	84692	broad.mit.edu	37	3	107096575	107096575	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:107096575T>A	uc003dwi.1	+	1	388	c.141T>A	c.(139-141)ACT>ACA	p.T47T		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	47											0						GATATCCCACTGTGACATCTG	0.383			NA											12	72					0	0	0.001855	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376009	113376009	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:113376009T>C	uc003eam.2	-	7	4931	c.4520A>G	c.(4519-4521)CAT>CGT	p.H1507R	KIAA2018_uc003eal.2_Missense_Mutation_p.H1451R	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1507	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GTGGACATTATGGGGCTGAGA	0.448			NA											6	49					0	0	0.001984	0	0
ATP6V1A	523	broad.mit.edu	37	3	113513802	113513802	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:113513802C>A	uc003eao.2	+	9	1138	c.1072C>A	c.(1072-1074)CTT>ATT	p.L358I	ATP6V1A_uc011bik.1_Missense_Mutation_p.L325I	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	358					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						GGCTGAGGCCCTTAGAGAAAT	0.453			NA											13	86					1.36491e-13	2.60595e-13	0.001855	1	0
GAP43	2596	broad.mit.edu	37	3	115395290	115395290	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:115395290C>T	uc003ebq.2	+	2	847	c.461C>T	c.(460-462)TCC>TTC	p.S154F	GAP43_uc003ebr.2_Missense_Mutation_p.S190F	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	154					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		TCGCCGTCCTCCAAGGCTGAA	0.448			NA											5	33					0	0	0.000602	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119134119	119134119	+	Missense_Mutation	SNP	A	A	T	rs12107254		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:119134119A>T	uc003ecj.3	+	12	3875	c.3343A>T	c.(3343-3345)ATT>TTT	p.I1115F		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1115					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						TGCCATTCCCATTGCTGACCT	0.522	Pancreas(7;176 297 5394 51128 51241)		NA											4	56					0	0	0.000248	0	0
FBXO40	51725	broad.mit.edu	37	3	121341476	121341476	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:121341476C>A	uc003eeg.2	+	3	1410	c.1200C>A	c.(1198-1200)CTC>CTA	p.L400L		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	400					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		AGACCACCCTCCAGTGTGCTT	0.458			NA											7	58					8.12818e-05	0.000110582	0.001984	1	0
DTX3L	151636	broad.mit.edu	37	3	122287986	122287986	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:122287986T>A	uc003efk.2	+	3	1139	c.1050T>A	c.(1048-1050)ATT>ATA	p.I350I	DTX3L_uc010hrj.2_Intron	NM_138287	NP_612144	Q8TDB6	DTX3L_HUMAN	deltex 3-like	350					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding	p.I350N(1)		ovary(2)|lung(1)|breast(1)	4				GBM - Glioblastoma multiforme(114;0.0459)		AAGATGACATTTCAGCTGCCA	0.383			NA											17	81					0	0	0.00499	0	0
HSPBAP1	79663	broad.mit.edu	37	3	122459941	122459941	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:122459941C>A	uc003efu.1	-	7	968	c.845G>T	c.(844-846)CGG>CTG	p.R282L	HSPBAP1_uc003eft.1_5'UTR	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	282	JmjC.					cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		CTCTTCTACCCGGGCTAGGTG	0.428			NA											13	47					1.52009e-12	2.85898e-12	0.003163	1	0
MYLK	4638	broad.mit.edu	37	3	123419658	123419658	+	Missense_Mutation	SNP	G	G	C	rs140989388		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:123419658G>C	uc003ego.2	-	18	2939	c.2657C>G	c.(2656-2658)GCG>GGG	p.A886G	MYLK_uc011bjw.1_Missense_Mutation_p.A886G|MYLK_uc003egp.2_Missense_Mutation_p.A817G|MYLK_uc003egq.2_Missense_Mutation_p.A886G|MYLK_uc003egr.2_Missense_Mutation_p.A817G|MYLK_uc003egs.2_Missense_Mutation_p.A710G|MYLK_uc003egt.2_Missense_Mutation_p.A77G	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	886	5 X 28 AA approximate tandem repeats.|1-1.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CTGGCGGATCGCCTCCTCAGT	0.622			NA											5	47					0	0	0.001984	0	0
KALRN	8997	broad.mit.edu	37	3	124281868	124281868	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:124281868G>A	uc003ehg.2	+	34	5235	c.5108G>A	c.(5107-5109)AGC>AAC	p.S1703N	KALRN_uc003ehi.2_Missense_Mutation_p.S76N	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1703	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTGGTCCCCAGCAGCGCCCTG	0.652			NA											11	41					0	0	0.008291	0	0
TF	7018	broad.mit.edu	37	3	133494456	133494456	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:133494456C>A	uc003epu.1	+	20	3595	c.1867C>A	c.(1867-1869)CAG>AAG	p.Q623K	TF_uc011blt.1_Missense_Mutation_p.Q496K|TF_uc003epw.1_Missense_Mutation_p.Q62K|TF_uc003epv.1_Missense_Mutation_p.Q623K	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	623	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	ATTACGTCAACAGCAGGTATG	0.537			NA											4	47					0.00024832	0.000325365	0.000248	1	0
DZIP1L	199221	broad.mit.edu	37	3	137822353	137822353	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:137822353T>A	uc003erq.2	-	2	824	c.461A>T	c.(460-462)CAG>CTG	p.Q154L	DZIP1L_uc003err.1_Missense_Mutation_p.Q154L	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	154						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						TAGCAGCTGCTGCAGGGTGCT	0.657			NA											4	19					0	0	0.000248	0	0
TRPC1	7220	broad.mit.edu	37	3	142523341	142523341	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:142523341A>G	uc003evc.2	+	12	2159	c.2023A>G	c.(2023-2025)AAA>GAA	p.K675E	TRPC1_uc003evb.2_Missense_Mutation_p.K641E	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	675					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						CTTTGATGACAAATGTACGTT	0.348			NA											6	42					0	0	0.001984	0	0
ZIC1	7545	broad.mit.edu	37	3	147128031	147128031	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:147128031G>T	uc003ewe.2	+	1	851	c.132G>T	c.(130-132)ATG>ATT	p.M44I		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	44					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCGACGGCATGGGCGCCTTCA	0.716			NA											5	41					0.00116845	0.00142726	0.001168	1	0
GPR87	53836	broad.mit.edu	37	3	151012145	151012145	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:151012145C>G	uc003eyt.2	-	3	1250	c.889G>C	c.(889-891)GAA>CAA	p.E297Q	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	297	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGTGTAATTTCTTTGCAGTAA	0.333			NA											5	73					0	0	0.001168	0	0
MED12L	116931	broad.mit.edu	37	3	151082916	151082916	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:151082916G>T	uc003eyp.2	+	20	3040	c.3002G>T	c.(3001-3003)AGT>ATT	p.S1001I	MED12L_uc011bnz.1_Missense_Mutation_p.S861I|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.S164I	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1001					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGATCCTCAGTGACAATGCG	0.483			NA											15	131					3.45872e-05	4.95473e-05	0.004007	1	0
MED12L	116931	broad.mit.edu	37	3	151101662	151101662	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:151101662C>A	uc003eyp.2	+	32	4709	c.4671C>A	c.(4669-4671)GAC>GAA	p.D1557E	MED12L_uc011bnz.1_Missense_Mutation_p.D1417E|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.D720E	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1557					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GAACTGTTGACATGCACACTA	0.438			NA											3	13					0.00024832	0.000325365	0.000248	1	0
B3GALNT1	8706	broad.mit.edu	37	3	160803765	160803765	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:160803765C>A	uc003fdv.2	-	5	1197	c.778G>T	c.(778-780)GTA>TTA	p.V260L	B3GALNT1_uc003fdw.2_Missense_Mutation_p.V260L|B3GALNT1_uc003fdx.2_Missense_Mutation_p.V260L|B3GALNT1_uc003fdy.2_Missense_Mutation_p.V260L|B3GALNT1_uc003fdz.2_Missense_Mutation_p.V260L|B3GALNT1_uc003fea.2_Missense_Mutation_p.V260L|B3GALNT1_uc011bpa.1_Intron	NM_033169	NP_149359	O75752	B3GL1_HUMAN	UDP-Gal:betaGlcNAc beta	260	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			ATGGGTTTTACGTGACCCATC	0.378			NA											6	57					3.59834e-05	5.08422e-05	0.001168	1	0
B3GALNT1	8706	broad.mit.edu	37	3	160804474	160804474	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:160804474C>A	uc003fdv.2	-	5	488	c.69G>T	c.(67-69)CTG>CTT	p.L23L	B3GALNT1_uc003fdw.2_Silent_p.L23L|B3GALNT1_uc003fdx.2_Silent_p.L23L|B3GALNT1_uc003fdy.2_Silent_p.L23L|B3GALNT1_uc003fdz.2_Silent_p.L23L|B3GALNT1_uc003fea.2_Silent_p.L23L|B3GALNT1_uc011bpa.1_Silent_p.L23L	NM_033169	NP_149359	O75752	B3GL1_HUMAN	UDP-Gal:betaGlcNAc beta	23	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			GTGACAGCAGCAGGAGGCTCC	0.532			NA											5	24					3.59834e-05	5.08422e-05	0.001168	1	0
SI	6476	broad.mit.edu	37	3	164709192	164709192	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:164709192C>A	uc003fei.2	-	44	5119	c.5057G>T	c.(5056-5058)CGT>CTT	p.R1686L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1686	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTGACCACCACGGACATGTAG	0.388			NA								HNSCC(35;0.089)			9	47					3.09899e-07	4.96537e-07	0.004482	1	0
SI	6476	broad.mit.edu	37	3	164714347	164714347	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:164714347C>A	uc003fei.2	-	40	4730	c.4668G>T	c.(4666-4668)AGG>AGT	p.R1556S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1556	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTTGTGATTCCTTGAGTATG	0.353			NA								HNSCC(35;0.089)			5	67					1.024e-07	1.70817e-07	0.000602	1	0
SKIL	6498	broad.mit.edu	37	3	170108878	170108878	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:170108878C>T	uc003fgu.2	+	6	2438	c.1726C>T	c.(1726-1728)CAG>TAG	p.Q576*	SKIL_uc011bps.1_Nonsense_Mutation_p.Q556*|SKIL_uc003fgv.2_Nonsense_Mutation_p.Q530*|SKIL_uc003fgw.2_Nonsense_Mutation_p.Q576*	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	576	Potential.				cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TGAAGAACAGCAGAATTTACA	0.313			NA											4	25					0	0	0.000248	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198682	170198682	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:170198682A>T	uc003fgz.2	-	7	1705	c.1389T>A	c.(1387-1389)GCT>GCA	p.A463A	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	463						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CAGGAGAACAAGCTTCCTTCT	0.498			NA											4	60					0	0	0.000248	0	0
FNDC3B	64778	broad.mit.edu	37	3	172028669	172028669	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:172028669G>C	uc003fhy.2	+	11	1424	c.1252G>C	c.(1252-1254)GAG>CAG	p.E418Q	FNDC3B_uc003fhz.3_Missense_Mutation_p.E418Q|FNDC3B_uc003fia.2_Missense_Mutation_p.E349Q	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	418	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AGAGTGGGATGAGGTAAGCTT	0.313			NA											14	71					0	0	0.003163	0	0
SPATA16	83893	broad.mit.edu	37	3	172835231	172835231	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:172835231C>A	uc003fin.3	-	2	449	c.291G>T	c.(289-291)CAG>CAT	p.Q97H		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	97					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TTATCTTTGCCTGTTTCTTTC	0.388			NA											18	129					3.99206e-14	7.66043e-14	0.007413	1	0
KCNMB2	10242	broad.mit.edu	37	3	178546087	178546087	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:178546087T>A	uc003fjd.2	+	4	692	c.349T>A	c.(349-351)TAC>AAC	p.Y117N	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Missense_Mutation_p.Y117N|KCNMB2_uc003fjf.2_Missense_Mutation_p.Y117N|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_Intron	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	117	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			CCTCCAGGTGTACGTTAACCT	0.473			NA											7	32					0	0	0.001984	0	0
RTP2	344892	broad.mit.edu	37	3	187416408	187416408	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:187416408G>T	uc003fro.1	-	2	985	c.556C>A	c.(556-558)CCG>ACG	p.P186T		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	186	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		TGGGCCCTCGGCTTGGAGGCT	0.597			NA											6	41					0.00116845	0.00142726	0.001168	1	0
MUC4	4585	broad.mit.edu	37	3	195497124	195497124	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr3:195497124A>G	uc011bto.1	-	7	13437	c.12977T>C	c.(12976-12978)GTC>GCC	p.V4326A	MUC4_uc003fuz.2_Intron|MUC4_uc003fva.2_5'UTR|MUC4_uc003fvb.2_5'UTR|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_5'UTR|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.V18A|MUC4_uc011bti.1_Missense_Mutation_p.V18A|MUC4_uc011btj.1_Missense_Mutation_p.V195A|MUC4_uc011btk.1_5'UTR|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Missense_Mutation_p.V218A|MUC4_uc003fvp.2_Missense_Mutation_p.V167A|MUC4_uc010hzu.1_Missense_Mutation_p.V1066A	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1211	NIDO.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGGGCATTGACCCACGTGAC	0.587			NA											3	16					0	0	0.004672	0	0
ZNF595	152687	broad.mit.edu	37	4	85778	85778	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:85778G>T	uc003fzv.1	+	4	539	c.383G>T	c.(382-384)GGA>GTA	p.G128V	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_5'UTR	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	128					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		GTGCAGAAAGGAGTTAATAAT	0.318			NA											7	21					1.12685e-05	1.66247e-05	0.004482	1	0
HAUS3	79441	broad.mit.edu	37	4	2238063	2238063	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:2238063T>A	uc003ges.1	-	4	1700	c.1470A>T	c.(1468-1470)GCA>GCT	p.A490A	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Intron|HAUS3_uc003get.1_Silent_p.A490A	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	490	Potential.				cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						GAGCAGATACTGCCAACTGAT	0.358			NA											6	50					0	0	0.001984	0	0
CRMP1	1400	broad.mit.edu	37	4	5844865	5844865	+	Missense_Mutation	SNP	C	C	T	rs146352571	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:5844865C>T	uc003gip.2	-	8	746	c.645G>A	c.(643-645)ATG>ATA	p.M215I	CRMP1_uc003gin.1_Missense_Mutation_p.M127I|CRMP1_uc003giq.2_Missense_Mutation_p.M215I|CRMP1_uc003gir.2_Missense_Mutation_p.M210I|CRMP1_uc003gis.2_Missense_Mutation_p.M329I	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	215					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CCGTGATGCCCATCTCCAGGA	0.408			NA											8	68					0	0	0.008291	0	0
GPR78	27201	broad.mit.edu	37	4	8589020	8589020	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:8589020C>T	uc003glk.2	+	3	1441	c.1022C>T	c.(1021-1023)CCG>CTG	p.P341L	CPZ_uc003gll.2_Intron	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	341	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						AAGAGAACCCCGCGCCCAGCG	0.637			NA											3	39					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	4	9241830	9241830	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:9241830C>A	uc011bwo.1	+	1	975	c.723C>A	c.(721-723)CAC>CAA	p.H241Q						RecName: Full=Ubiquitin carboxyl-terminal hydrolase 17-like protein 2;          EC=3.1.2.15; AltName: Full=Ubiquitin thioesterase 17-like protein 2; AltName: Full=Ubiquitin-specific-processing protease 17-like protein 2; AltName: Full=Deubiquitinating enzyme 17-like protein 2; AltName: Full=Deubiquitinating protein 3;          Short=DUB-3;												NA						TGCTGGTCCACGCTGAGTGGA	0.493			NA											8	51					0.00448238	0.00529312	0.004482	1	0
APBB2	323	broad.mit.edu	37	4	40895341	40895341	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:40895341T>C	uc003gvl.2	-	11	1969	c.1339A>G	c.(1339-1341)ATC>GTC	p.I447V	APBB2_uc010ifu.2_Missense_Mutation_p.I19V|APBB2_uc003gvm.2_Missense_Mutation_p.I426V|APBB2_uc003gvn.2_Missense_Mutation_p.I448V|APBB2_uc011byt.1_Missense_Mutation_p.I409V	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	447	PID 1.				cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						AGTTGCCTGATGCAGTTGTTG	0.512	Ovarian(3;20 75 16686 49997)		NA											10	111					0	0	0.001368	0	0
GABRG1	2565	broad.mit.edu	37	4	46099313	46099313	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:46099313C>T	uc003gxb.2	-	2	310	c.158G>A	c.(157-159)TGG>TAG	p.W53*		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	53	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GGCCAAGACCCAGGTTTTGTT	0.358			NA											6	106					0	0	0.001984	0	0
GABRB1	2560	broad.mit.edu	37	4	47427945	47427945	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:47427945T>A	uc003gxh.2	+	9	1709	c.1335T>A	c.(1333-1335)GAT>GAA	p.D445E	GABRB1_uc011bze.1_Missense_Mutation_p.D375E	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	445	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACTTGACTGATGTGAATTCCA	0.537			NA											23	81					0	0	0.004656	0	0
PDGFRA	5156	broad.mit.edu	37	4	55152085	55152085	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:55152085G>T	uc003han.3	+	18	2848	c.2517G>T	c.(2515-2517)CTG>CTT	p.L839L	PDGFRA_uc003haa.2_Silent_p.L599L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	839	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ACTTTGGCCTGGCCAGAGACA	0.488	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			8	96					0.000157383	0.000211083	0.00308	1	0
KDR	3791	broad.mit.edu	37	4	55981471	55981471	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:55981471T>C	uc003has.2	-	4	768	c.466A>G	c.(466-468)AAT>GAT	p.N156D	KDR_uc003hat.1_Missense_Mutation_p.N156D|KDR_uc011bzx.1_Missense_Mutation_p.N156D	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	156	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ACGTTGAGATTTGAAATGGAC	0.363			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			3	29					0	0	0.000248	0	0
CEP135	9662	broad.mit.edu	37	4	56837457	56837457	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:56837457G>C	uc003hbi.2	+	10	1366	c.1132G>C	c.(1132-1134)GAA>CAA	p.E378Q	CEP135_uc003hbj.2_Missense_Mutation_p.E84Q	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	378	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					ATGCCAGAAAGAAAAGGAGAG	0.299			NA											8	29					0	0	0.004482	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181776	57181776	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:57181776G>A	uc003hbk.2	+	8	2499	c.2108G>A	c.(2107-2109)TGT>TAT	p.C703Y	KIAA1211_uc010iha.2_Missense_Mutation_p.C696Y|KIAA1211_uc011bzz.1_Missense_Mutation_p.C613Y|KIAA1211_uc003hbm.1_Missense_Mutation_p.C589Y	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	703										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AGGGGCCGGTGTGATTCCCGC	0.587			NA											7	54					0	0	0.00308	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660267	77660267	+	Missense_Mutation	SNP	G	G	T	rs140762344	byFrequency	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:77660267G>T	uc011cbx.1	+	5	1894	c.941G>T	c.(940-942)CGG>CTG	p.R314L	SHROOM3_uc011cbz.1_Missense_Mutation_p.R138L|SHROOM3_uc003hkf.1_Missense_Mutation_p.R189L|SHROOM3_uc003hkg.2_Missense_Mutation_p.R92L	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	314					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TATGACACCCGGAGGGGAGTC	0.547			NA											9	49					1.76689e-08	3.00478e-08	0.006214	1	0
FRAS1	80144	broad.mit.edu	37	4	79460460	79460460	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:79460460C>T	uc003hlb.2	+	73	11751	c.11311C>T	c.(11311-11313)CCA>TCA	p.P3771S		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3766	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CCGCAATCAGCCAGAGGTAAC	0.443			NA											6	62					0	0	0.001168	0	0
MEPE	56955	broad.mit.edu	37	4	88766351	88766351	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:88766351G>T	uc003hqy.2	+	4	370	c.331G>T	c.(331-333)GGC>TGC	p.G111C	MEPE_uc010ikn.2_5'UTR	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	111					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TACTCACAATGGCCTGAGGAT	0.363			NA											5	35					3.59834e-05	5.08422e-05	0.001168	1	0
Unknown	0	broad.mit.edu	37	4	88813169	88813169	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:88813169C>T	uc010iko.1	+	1	175	c.175C>T	c.(175-177)CTG>TTG	p.L59L						SubName: Full=Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a; SubName: Full=cDNA, FLJ92550, Homo sapiens heat shock 90kDa protein 1, beta (HSPCB), mRNA;												NA						CTATGAGAGCCTGACAGACCC	0.463			NA											7	54					0	0	0.001984	0	0
MMRN1	22915	broad.mit.edu	37	4	90857932	90857932	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:90857932A>G	uc003hst.2	+	6	3172	c.3101A>G	c.(3100-3102)GAC>GGC	p.D1034G	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.D776G	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1034					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AGAAACACGGACAACATAATA	0.348			NA											6	27					0	0	0.001168	0	0
GRID2	2895	broad.mit.edu	37	4	94411820	94411820	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:94411820C>A	uc011cdt.1	+	12	2147	c.1889C>A	c.(1888-1890)ACC>AAC	p.T630N	GRID2_uc011cdu.1_Missense_Mutation_p.T535N	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	630	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ACTCTGGCTACCCGAATGATG	0.428			NA											7	56					0.00198382	0.00238984	0.001984	1	0
MTTP	4547	broad.mit.edu	37	4	100503247	100503247	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:100503247A>G	uc003hvc.3	+	3	503	c.247A>G	c.(247-249)ACG>GCG	p.T83A	MTTP_uc011cej.1_Missense_Mutation_p.T110A|MTTP_uc003hvb.2_Missense_Mutation_p.T83A	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	83	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GATCCAAATAACGGTGGGCAT	0.428			NA											5	39					0	0	0.000602	0	0
EGF	1950	broad.mit.edu	37	4	110909824	110909824	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:110909824G>C	uc003hzy.3	+	18	3145	c.2693G>C	c.(2692-2694)CGG>CCG	p.R898P	EGF_uc011cfu.1_Missense_Mutation_p.R856P|EGF_uc011cfv.1_Missense_Mutation_p.R898P|EGF_uc010imk.2_Intron	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	898	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TATGTCTGCCGGTGCTCAGAA	0.532			NA											10	44					0	0	0.008291	0	0
ELOVL6	79071	broad.mit.edu	37	4	110972668	110972668	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:110972668C>A	uc003hzz.2	-	5	750	c.624G>T	c.(622-624)ATG>ATT	p.M208I	ELOVL6_uc003iaa.2_Missense_Mutation_p.M208I	NM_001130721	NP_001124193	Q9H5J4	ELOV6_HUMAN	elongation of very long chain fatty acids-like	208	Helical; (Potential).				fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		CCACACAGCCCATCAGCATCT	0.517			NA											7	34					8.12818e-05	0.000110582	0.001984	1	0
ANK2	287	broad.mit.edu	37	4	114276332	114276332	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:114276332G>T	uc003ibe.3	+	38	6658	c.6558G>T	c.(6556-6558)GAG>GAT	p.E2186D	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.E2201D	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2153					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGAAAGATGAGTTCCTTCCAG	0.493			NA											8	40					3.09899e-07	4.96537e-07	0.004482	1	0
TRPC3	7222	broad.mit.edu	37	4	122833087	122833087	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:122833087C>A	uc003ieg.2	-	5	1577	c.1503G>T	c.(1501-1503)AGG>AGT	p.R501S	TRPC3_uc010inr.2_Missense_Mutation_p.R373S|TRPC3_uc003ief.2_Missense_Mutation_p.R428S|TRPC3_uc011cgl.1_Missense_Mutation_p.R165S	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	416	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TGGTTTTCACCCTGAAGATCT	0.413			NA											6	55					2.0095e-06	3.08069e-06	0.001984	1	0
FAT4	79633	broad.mit.edu	37	4	126242248	126242248	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:126242248G>A	uc003ifj.3	+	1	4682	c.4682G>A	c.(4681-4683)GGA>GAA	p.G1561E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1561	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGTGCTAATGGAGAAATAGAG	0.463			NA											10	100					0	0	0.006214	0	0
PCDH10	57575	broad.mit.edu	37	4	134073228	134073228	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:134073228C>G	uc003iha.2	+	1	2759	c.1933C>G	c.(1933-1935)CCG>GCG	p.P645A	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.P645A	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	645	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		ACGCCGAGTCCCGGCCAAGCG	0.662			NA											5	40					0	0	0.000602	0	0
PCDH18	54510	broad.mit.edu	37	4	138451556	138451556	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:138451556C>G	uc003ihe.3	-	1	2074	c.1687G>C	c.(1687-1689)GTG>CTG	p.V563L	PCDH18_uc003ihf.3_Missense_Mutation_p.V556L|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.V343L|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	563	Extracellular (Potential).|Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					ATGGTGAGCACAACTGTGGTA	0.453			NA											23	115					0	0	0.00278	0	0
POU4F2	5458	broad.mit.edu	37	4	147561855	147561855	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:147561855C>G	uc003ikv.2	+	2	1373	c.1125C>G	c.(1123-1125)ATC>ATG	p.I375M		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	375	Homeobox.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					CTGAAAAGATCGCCGCCATCG	0.577			NA											4	57					0	0	0.000248	0	0
GRIA2	2891	broad.mit.edu	37	4	158224837	158224837	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:158224837A>T	uc003ipm.3	+	3	822	c.363A>T	c.(361-363)ACA>ACT	p.T121T	GRIA2_uc011cit.1_Silent_p.T74T|GRIA2_uc003ipl.3_Silent_p.T121T|GRIA2_uc003ipk.3_Silent_p.T74T|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	121	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CAGATGGCACACATCCATTTG	0.428			NA											4	69					0	0	0.001168	0	0
SPOCK3	50859	broad.mit.edu	37	4	167663171	167663171	+	Missense_Mutation	SNP	C	C	A	rs138814470		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:167663171C>A	uc003iri.1	-	10	1121	c.980G>T	c.(979-981)CGG>CTG	p.R327L	SPOCK3_uc011cjp.1_Missense_Mutation_p.R284L|SPOCK3_uc011cjq.1_Missense_Mutation_p.R336L|SPOCK3_uc011cjr.1_Missense_Mutation_p.R207L|SPOCK3_uc003irj.1_Missense_Mutation_p.R324L|SPOCK3_uc011cjs.1_Missense_Mutation_p.R276L|SPOCK3_uc011cjt.1_Missense_Mutation_p.R235L|SPOCK3_uc011cju.1_Missense_Mutation_p.R220L|SPOCK3_uc011cjv.1_Missense_Mutation_p.R229L	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	327	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TACCCCTTGCCGCTTCTGAAT	0.378			NA											23	41					6.21321e-17	1.2086e-16	0.00278	1	0
PALLD	23022	broad.mit.edu	37	4	169611826	169611826	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:169611826C>T	uc011cjx.1	+	7	1619	c.1408C>T	c.(1408-1410)CTG>TTG	p.L470L	PALLD_uc003iru.2_Silent_p.L470L|PALLD_uc003irv.2_Silent_p.L88L	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	470	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GGCACCCCCTCTGCAGGTCCA	0.527	Esophageal Squamous(109;1482 1532 18347 40239 51172)		NA							Pancreatic_Cancer_Familial_Clustering_of				10	79					0	0	0.001368	0	0
TRIML1	339976	broad.mit.edu	37	4	189060757	189060757	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:189060757C>A	uc003izm.1	+	1	160	c.45C>A	c.(43-45)ACC>ACA	p.T15T		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	15					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGGAACTCACCTGTTTCATCT	0.507	Melanoma(31;213 1036 16579 23968 32372)		NA											9	112					3.86212e-05	5.4165e-05	0.008291	1	0
TRIML1	339976	broad.mit.edu	37	4	189068316	189068316	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr4:189068316C>A	uc003izm.1	+	6	1312	c.1197C>A	c.(1195-1197)CAC>CAA	p.H399Q	TRIML1_uc003izn.1_Missense_Mutation_p.H123Q	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	399	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AAGGTCAGCACGTCAGAGAGC	0.488	Melanoma(31;213 1036 16579 23968 32372)		NA											8	64					0.00307968	0.00367105	0.00308	1	0
PLEKHG4B	153478	broad.mit.edu	37	5	163417	163417	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:163417A>G	uc003jak.2	+	11	2212	c.2162A>G	c.(2161-2163)AAG>AGG	p.K721R		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	721					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CATCCCCAGAAGAAAATGATA	0.607			NA											13	89					0	0	0.001368	0	0
SDHA	6389	broad.mit.edu	37	5	240507	240507	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:240507G>T	uc003jao.3	+	11	1582	c.1467G>T	c.(1465-1467)GGG>GGT	p.G489G	SDHA_uc011clv.1_Silent_p.G489G|SDHA_uc011clw.1_Silent_p.G441G|SDHA_uc003jap.3_Silent_p.G489G|SDHA_uc003jaq.3_Silent_p.G264G|SDHA_uc003jar.3_Silent_p.G83G	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	489					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CAAACGCTGGGGAAGAATCTG	0.373			NA							Familial_Paragangliomas				8	30					0.000157383	0.000211083	0.00308	1	0
AHRR	57491	broad.mit.edu	37	5	434078	434078	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:434078G>T	uc003jav.2	+	12	1333	c.1289G>T	c.(1288-1290)AGT>ATT	p.S430I	AHRR_uc003jaw.2_Missense_Mutation_p.S408I|AHRR_uc010isy.2_Missense_Mutation_p.S258I|AHRR_uc010isz.2_Missense_Mutation_p.S408I|AHRR_uc003jax.2_Missense_Mutation_p.S171I|AHRR_uc003jay.2_Missense_Mutation_p.S268I|AHRR_uc003jaz.2_Missense_Mutation_p.S29I	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GGAAAGCACAGTGAGGATGGT	0.687			NA											3	34					1.23904e-05	1.80687e-05	0.000602	1	0
SLC6A19	340024	broad.mit.edu	37	5	1213663	1213663	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:1213663G>T	uc003jbw.3	+	5	805	c.749G>T	c.(748-750)GGC>GTC	p.G250V		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	250	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCCACCAATGGCATCGTCTTC	0.662			NA											7	26					0.000274275	0.000355681	0.004482	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5319161	5319161	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:5319161C>A	uc003jdl.2	+	23	3723	c.3585C>A	c.(3583-3585)CAC>CAA	p.H1195Q		NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1195	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ACTACTTCCACTGGTGCTACC	0.527			NA											4	16					2.56e-06	3.89312e-06	0.000248	1	0
DNAH5	1767	broad.mit.edu	37	5	13824389	13824389	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:13824389T>C	uc003jfd.2	-	39	6540	c.6498A>G	c.(6496-6498)GGA>GGG	p.G2166G		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2166					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTTTTGCTGCTCCCAAGGTCC	0.418			NA							Kartagener_syndrome				4	46					0	0	0.001168	0	0
DNAH5	1767	broad.mit.edu	37	5	13894882	13894882	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:13894882T>C	uc003jfd.2	-	16	2350	c.2308A>G	c.(2308-2310)ATT>GTT	p.I770V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	770	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AATTGCTCAATGGCAGCAGGT	0.413			NA							Kartagener_syndrome				11	104					0	0	0.001855	0	0
ZNF622	90441	broad.mit.edu	37	5	16458721	16458721	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:16458721T>A	uc003jfq.2	-	4	1187	c.1067A>T	c.(1066-1068)CAC>CTC	p.H356L		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	356						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						CCCTTCCTTGTGATCTGGATA	0.383			NA											3	43					0	0	0.000248	0	0
BASP1	10409	broad.mit.edu	37	5	17275906	17275906	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:17275906G>T	uc003jfx.2	+	2	760	c.581G>T	c.(580-582)AGT>ATT	p.S194I		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	194					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						GAAGCGCCTAGTTCCACACCC	0.647			NA											6	22					5.18039e-06	7.8153e-06	0.00308	1	0
CDH12	1010	broad.mit.edu	37	5	21752217	21752217	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:21752217C>G	uc010iuc.2	-	12	2472	c.2014G>C	c.(2014-2016)GCT>CCT	p.A672P	CDH12_uc011cno.1_Missense_Mutation_p.A632P|CDH12_uc003jgk.2_Missense_Mutation_p.A672P|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	672	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						ATGTCGAAAGCCTGGGTATCT	0.463			NA								HNSCC(59;0.17)			5	78					0	0	0.000602	0	0
PRDM9	56979	broad.mit.edu	37	5	23509603	23509603	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:23509603T>A	uc003jgo.2	+	3	276	c.94T>A	c.(94-96)TCC>ACC	p.S32T		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	32	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CAAAGACATTTCCATATACTT	0.413			NA								HNSCC(3;0.000094)			30	112					0	0	0.007291	0	0
CDH10	1008	broad.mit.edu	37	5	24487989	24487989	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:24487989C>A	uc003jgr.1	-	12	2482	c.2150G>T	c.(2149-2151)AGG>ATG	p.R717M	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	717	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CTCTTTTAGCCTTTCATTAAT	0.458			NA								HNSCC(23;0.051)			7	46					1.6384e-10	2.95432e-10	0.001984	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33527362	33527362	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:33527362G>C	uc003jia.1	-	24	4879	c.4716C>G	c.(4714-4716)CCC>CCG	p.P1572P	ADAMTS12_uc010iuq.1_Silent_p.P1487P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1572	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGTGTGTCTGGGGACACGAGA	0.512			NA								HNSCC(64;0.19)			22	98					0	0	0.00333	0	0
SLC45A2	51151	broad.mit.edu	37	5	33984644	33984644	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:33984644G>T	uc003jid.2	-	1	137	c.45C>A	c.(43-45)TCC>TCA	p.S15S	SLC45A2_uc003jie.2_Silent_p.S15S|SLC45A2_uc003jif.3_Silent_p.S15S|SLC45A2_uc011coe.1_Silent_p.S15S	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	15	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CATCAGCTAGGGATTTATAGA	0.582	Ovarian(31;380 859 8490 22203 49048)		NA											6	36					2.0095e-06	3.08069e-06	0.001984	1	0
SPEF2	79925	broad.mit.edu	37	5	35644577	35644577	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:35644577G>T	uc003jjo.2	+	4	646	c.535G>T	c.(535-537)GAA>TAA	p.E179*	SPEF2_uc003jjn.1_Nonsense_Mutation_p.E179*|SPEF2_uc003jjq.3_Nonsense_Mutation_p.E179*	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	179					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGAGAAACTTGAAAGATTTCA	0.308			NA											3	18					6.4e-05	8.8683e-05	0.004672	1	0
UGT3A2	167127	broad.mit.edu	37	5	36037999	36037999	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:36037999C>A	uc003jjz.1	-	6	1288	c.1195G>T	c.(1195-1197)GTC>TTC	p.V399F	UGT3A2_uc011cos.1_Missense_Mutation_p.V365F|UGT3A2_uc011cot.1_Missense_Mutation_p.V97F	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	399	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTACTCGGACCATGTTTTCA	0.478			NA											12	86					0.000219431	0.000293264	0.00245	1	0
SLC1A3	6507	broad.mit.edu	37	5	36608588	36608588	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:36608588A>T	uc003jkj.3	+	2	539	c.63A>T	c.(61-63)GGA>GGT	p.G21G	SLC1A3_uc011cox.1_5'UTR|SLC1A3_uc010iuy.2_Silent_p.G21G	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	21	Cytoplasmic (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TCCAGCAGGGAGTCCGTAAAC	0.448			NA											17	66					0	0	0.00499	0	0
FYB	2533	broad.mit.edu	37	5	39203004	39203004	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:39203004G>T	uc003jls.2	-	1	126	c.59C>A	c.(58-60)CCC>CAC	p.P20H	FYB_uc003jlt.2_Missense_Mutation_p.P20H|FYB_uc003jlu.2_Missense_Mutation_p.P20H|FYB_uc011cpl.1_Missense_Mutation_p.P30H	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	20					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			GACTCTGAAGGGTCGGCTATT	0.488			NA											11	55					3.86212e-05	5.4165e-05	0.008291	1	0
SLC38A9	153129	broad.mit.edu	37	5	54960597	54960597	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:54960597C>A	uc003jqf.2	-	8	822	c.621G>T	c.(619-621)GTG>GTT	p.V207V	SLC38A9_uc003jqd.2_Silent_p.V144V|SLC38A9_uc010ivx.2_Silent_p.V180V|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Silent_p.V78V	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	207	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				CAATGAGAGACACCAAGGAGA	0.373			NA											8	29					0.00307968	0.00367105	0.00308	1	0
MAST4	375449	broad.mit.edu	37	5	66460666	66460666	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:66460666C>T	uc003jut.1	+	28	5160	c.5092C>T	c.(5092-5094)CCA>TCA	p.P1698S	MAST4_uc003juw.2_Missense_Mutation_p.P1626S|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1890						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCAGAATTCACCAGCAGTTTC	0.542			NA											7	29					0	0	0.00308	0	0
VCAN	1462	broad.mit.edu	37	5	82815784	82815784	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:82815784A>T	uc003kii.3	+	7	2015	c.1659A>T	c.(1657-1659)GGA>GGT	p.G553G	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Silent_p.G553G|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	553	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCACCTTGGGAGAAGAGGATG	0.413			NA											7	83					0	0	0.001984	0	0
APC	324	broad.mit.edu	37	5	112111325	112111325	+	Splice_Site	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:112111325G>T	uc010jby.2	+	5	803	c.423_splice	c.e5-1	p.R141_splice	APC_uc011cvt.1_Splice_Site_p.R151_splice|APC_uc003kpz.3_Splice_Site_p.R141_splice|APC_uc003kpy.3_Splice_Site_p.R141_splice|APC_uc010jbz.2_Splice_Site	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli						canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(2)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		aaaaaaaataGGTCATTGCTT	0.313	NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			7	32					1.26484e-09	2.23115e-09	0.00308	1	0
AQPEP	206338	broad.mit.edu	37	5	115338596	115338596	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:115338596G>T	uc003kro.2	+	11	2049	c.1885G>T	c.(1885-1887)GAT>TAT	p.D629Y	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	629	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						AGTCTGGCTAGATCAAAGCAG	0.294			NA											4	30					5.9392e-07	9.42309e-07	0.001168	1	0
ZNF474	133923	broad.mit.edu	37	5	121487812	121487812	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:121487812C>A	uc003ksv.2	+	2	503	c.127C>A	c.(127-129)CCA>ACA	p.P43T		NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	43						intracellular	zinc ion binding				0		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		TAGCCTTTCCCCAGAAACAGA	0.388			NA											11	96					2.80697e-09	4.92087e-09	0.000978	1	0
MEGF10	84466	broad.mit.edu	37	5	126667014	126667014	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:126667014T>G	uc003kuh.3	+	3	376	c.14T>G	c.(13-15)TTG>TGG	p.L5W	MEGF10_uc010jdc.1_Missense_Mutation_p.L5W|MEGF10_uc010jdd.1_Missense_Mutation_p.L5W|MEGF10_uc003kui.3_Missense_Mutation_p.L5W	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	5	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		GTTATTTCTTTGAACTCATGC	0.368			NA											8	46					0	0	0.00308	0	0
HINT1	3094	broad.mit.edu	37	5	130500840	130500840	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:130500840C>T	uc003kve.3	-	1	195	c.59G>A	c.(58-60)GGG>GAG	p.G20E	HINT1_uc011cxd.1_RNA|HINT1_uc003kvf.3_RNA	NM_005340	NP_005331	P49773	HINT1_HUMAN	histidine triad nucleotide binding protein 1	20	HIT.				signal transduction	cytoplasm|cytoskeleton|nucleus	hydrolase activity|protein kinase C binding				0		all_cancers(142;0.0452)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Adenosine monophosphate(DB00131)	GATGATCTTCCCAAAGATCGT	0.597			NA											3	46					0	0	0.000248	0	0
NRG2	9542	broad.mit.edu	37	5	139231259	139231259	+	Silent	SNP	G	G	T	rs141346193		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:139231259G>T	uc003lex.1	-	9	1927	c.1702C>A	c.(1702-1704)CGG>AGG	p.R568R	NRG2_uc003lev.1_Silent_p.R576R|NRG2_uc003lew.1_Silent_p.R570R|NRG2_uc003ley.1_Silent_p.R562R	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	568	Cytoplasmic (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTGCGCCGCTCCTCCAGG	0.637			NA											11	40					3.86212e-05	5.4165e-05	0.008291	1	0
PCDHA6	56142	broad.mit.edu	37	5	140209049	140209049	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140209049C>A	uc003lho.2	+	1	1400	c.1373C>A	c.(1372-1374)CCC>CAC	p.P458H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.P458H|PCDHA6_uc011dab.1_Missense_Mutation_p.P458H	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	458	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGCGCAGCCCGAGTACACA	0.662			NA											10	45					9.70103e-10	1.72463e-09	0.008291	1	0
PCDHA9	9752	broad.mit.edu	37	5	140229634	140229634	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140229634C>A	uc003lhu.2	+	1	2278	c.1554C>A	c.(1552-1554)TAC>TAA	p.Y518*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Nonsense_Mutation_p.Y518*	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	518	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGGTGTACGCGCTGCAGC	0.687	Melanoma(55;1800 1972 14909)		NA											14	71					9.31168e-06	1.39368e-05	0.001855	1	0
PCDHA13	56136	broad.mit.edu	37	5	140263618	140263618	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140263618C>T	uc003lif.2	+	1	1765	c.1765C>T	c.(1765-1767)CAC>TAC	p.H589Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.H589Y|PCDHA13_uc003lid.2_Missense_Mutation_p.H589Y	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	589	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGCAGGCCACGTGGTGGC	0.697	Melanoma(147;1739 1852 5500 27947 37288)		NA											4	48					0	0	0.000248	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482259	140482259	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140482259G>T	uc003lio.2	+	1	2026	c.2026G>T	c.(2026-2028)GCG>TCG	p.A676S	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	676	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTCCCGGAGGCGGCACCGGC	0.667			NA											9	116					3.86212e-05	5.4165e-05	0.008291	1	0
PCDHB8	56128	broad.mit.edu	37	5	140559505	140559505	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140559505G>A	uc011dai.1	+	1	2076	c.1890G>A	c.(1888-1890)CTG>CTA	p.L630L	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	630	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGCCAGGCTGCTGAGCGAGC	0.697			NA											9	51					0	0	0.006214	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580808	140580808	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140580808C>G	uc003liy.2	+	1	1461	c.1461C>G	c.(1459-1461)AAC>AAG	p.N487K	PCDHB11_uc011daj.1_Missense_Mutation_p.N122K	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	487	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCAGGTCAACTACTCGCTAC	0.637			NA											10	77					0	0	0.006214	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581670	140581670	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140581670C>A	uc003liy.2	+	1	2323	c.2323C>A	c.(2323-2325)CAG>AAG	p.Q775K	PCDHB11_uc011daj.1_Missense_Mutation_p.Q410K	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	775	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTAATATCCAGGCAAAAGG	0.418			NA											7	47					8.12818e-05	0.000110582	0.001984	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140711649	140711649	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140711649C>T	uc003lji.1	+	1	1398	c.1398C>T	c.(1396-1398)CCC>CCT	p.P466P	PCDHGA1_uc011dan.1_Silent_p.P466P	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	466	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAACAACCCCAGAGGAGCCT	0.488			NA											5	71					0	0	0.001168	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736259	140736260	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140736259_140736260GG>CT	uc003ljq.1	+	1	1492_1493	c.1492_1493GG>CT	c.(1492-1494)GGT>CTT	p.G498L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.G498L	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	498	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCTTCCAGGGTGCACCTCTG	0.52			NA											14	89					0	0	0.004672	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744467	140744467	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140744467G>T	uc003lju.1	+	1	570	c.570G>T	c.(568-570)AAG>AAT	p.K190N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.K190N	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	190	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGACAAAAGTATCCGGAGC	0.562			NA											6	31					3.59834e-05	5.08422e-05	0.001168	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140774114	140774114	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:140774114G>T	uc003lkd.1	+	1	2632	c.1734G>T	c.(1732-1734)GCG>GCT	p.A578A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.A578A	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	578	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGCTGGCGCCCCGCTCCG	0.657			NA											17	80					2.48551e-13	4.72954e-13	0.00499	1	0
FBXO38	81545	broad.mit.edu	37	5	147806775	147806775	+	Splice_Site	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:147806775G>C	uc003lpf.1	+	15	2039	c.1919_splice	c.e15-1	p.V640_splice	FBXO38_uc003lpg.1_Splice_Site_p.V640_splice|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b							cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTATAAGCAGTAAGTGGAAA	0.423			NA											4	24					0	0	0.000248	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479626	156479626	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:156479626G>A	uc010jij.1	-	4	604	c.419C>T	c.(418-420)ACC>ATC	p.T140I	HAVCR1_uc011ddl.1_5'UTR|HAVCR1_uc003lwi.2_Missense_Mutation_p.T140I|HAVCR1_uc011ddm.1_Missense_Mutation_p.T140I	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	140	Extracellular (Potential).|11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.|1.				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTCGTGACGGTTGGAACAGT	0.473			NA											10	164					0	0	0.000978	0	0
ITK	3702	broad.mit.edu	37	5	156608057	156608057	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:156608057C>T	uc003lwo.1	+	1	151	c.69C>T	c.(67-69)CCC>CCT	p.P23P		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	23	PH.		P -> L (in a metastatic melanoma sample; somatic mutation).		cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.P23L(1)		lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAACTTCTCCCTCGAACTTTA	0.433	Esophageal Squamous(70;1378 1469 8785 19883)		NA	T	SYK	peripheral T-cell lymphoma								8	101					0	0	0.004482	0	0
ADAM19	8728	broad.mit.edu	37	5	156915444	156915444	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:156915444G>T	uc003lwz.2	-	21	2443	c.2379C>A	c.(2377-2379)CCC>CCA	p.P793P	ADAM19_uc003lww.1_Silent_p.P526P|ADAM19_uc003lwy.2_Silent_p.P392P|ADAM19_uc011ddr.1_Silent_p.P724P	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	793	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AATCTGGAGGGGGCCGGGGAG	0.602			NA											6	32					0.00198382	0.00238984	0.001984	1	0
ADAM19	8728	broad.mit.edu	37	5	156997941	156997941	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:156997941G>A	uc003lwz.2	-	2	206	c.142C>T	c.(142-144)CCT>TCT	p.P48S	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_5'UTR	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	48					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTCCACTGAGGTATGATAAGT	0.483			NA											7	38					0	0	0.00308	0	0
GABRA1	2554	broad.mit.edu	37	5	161324315	161324315	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:161324315G>T	uc010jiw.2	+	11	1726	c.1258G>T	c.(1258-1260)GAC>TAC	p.D420Y	GABRA1_uc010jix.2_Missense_Mutation_p.D420Y|GABRA1_uc010jiy.2_Missense_Mutation_p.D420Y|GABRA1_uc003lyx.3_Missense_Mutation_p.D420Y|GABRA1_uc010jiz.2_Missense_Mutation_p.D420Y|GABRA1_uc010jja.2_Missense_Mutation_p.D420Y|GABRA1_uc010jjb.2_Missense_Mutation_p.D420Y	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	420	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CAGCAAAATTGACCGACTGTC	0.443			NA											6	78					0.00198382	0.00238984	0.001984	1	0
SLIT3	6586	broad.mit.edu	37	5	168114017	168114017	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:168114017T>A	uc003mab.2	-	30	3701	c.3281A>T	c.(3280-3282)AAT>ATT	p.N1094I	SLIT3_uc010jjg.2_Missense_Mutation_p.N1101I	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1094	EGF-like 5.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTGTAGCCATTGATTGTGTC	0.632	Ovarian(29;311 847 10864 17279 24903)		NA											9	34					0	0	0.004482	0	0
SLIT3	6586	broad.mit.edu	37	5	168135007	168135007	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:168135007G>A	uc003mab.2	-	26	3238	c.2818C>T	c.(2818-2820)CGC>TGC	p.R940C	SLIT3_uc010jjg.2_Missense_Mutation_p.R947C	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	940	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGCACAGCGGTACAGCTCC	0.617	Ovarian(29;311 847 10864 17279 24903)		NA											5	26					0	0	0.00308	0	0
C5orf25	375484	broad.mit.edu	37	5	175763870	175763870	+	Silent	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:175763870C>G	uc003mds.3	+	10	2669	c.2262C>G	c.(2260-2262)CTC>CTG	p.L754L	C5orf25_uc003mdt.3_Silent_p.L339L|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Silent_p.L215L			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	754											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		CGTCACTGCTCAAGTGTCAGG	0.483			NA											6	19					0	0	0.001168	0	0
HK3	3101	broad.mit.edu	37	5	176314464	176314464	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:176314464G>T	uc003mfa.2	-	11	1680	c.1588C>A	c.(1588-1590)CCT>ACT	p.P530T	HK3_uc003mez.2_Missense_Mutation_p.P86T	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	530	Catalytic.			PD -> LT (in Ref. 4; AAC50422).	glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCCGTCAGGGGTGGCCCGG	0.672			NA											5	32					1.23904e-05	1.80687e-05	0.000602	1	0
ZNF346	23567	broad.mit.edu	37	5	176489059	176489059	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:176489059C>T	uc003mfi.2	+	6	747	c.704C>T	c.(703-705)GCT>GTT	p.A235V	ZNF346_uc011dfr.1_Missense_Mutation_p.A203V|ZNF346_uc011dfs.1_Missense_Mutation_p.A137V|ZNF346_uc003mfj.2_Missense_Mutation_p.A59V|ZNF346_uc003mfk.1_Missense_Mutation_p.A260V|ZNF346_uc011dft.1_Missense_Mutation_p.A59V	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	235						cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTGTTTCAGCTGGAAAGGGC	0.438			NA											5	100					0	0	0.001168	0	0
DDX41	51428	broad.mit.edu	37	5	176940389	176940389	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:176940389C>A	uc003mho.2	-	11	1216	c.1195G>T	c.(1195-1197)GGG>TGG	p.G399W	DOK3_uc003mhi.3_5'Flank|DOK3_uc003mhj.3_5'Flank|DDX41_uc003mhm.2_Missense_Mutation_p.G179W|DDX41_uc003mhn.2_Missense_Mutation_p.G268W|DDX41_uc003mhp.2_Missense_Mutation_p.G268W|DDX41_uc003mhq.1_Missense_Mutation_p.G179W	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	399					apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			CCAGCGCGCCCCACATTGATG	0.592			NA											22	108					3.28513e-13	6.24064e-13	0.003954	1	0
ZNF354C	30832	broad.mit.edu	37	5	178505705	178505705	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:178505705C>G	uc003mju.2	+	5	387	c.272C>G	c.(271-273)ACA>AGA	p.T91R		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TGGCTTGAAACAGAAGCATTG	0.373			NA											4	37					0	0	0.001168	0	0
DUSP22	56940	broad.mit.edu	37	6	348191	348191	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:348191G>T	uc003msx.2	+	6	791	c.352G>T	c.(352-354)GTG>TTG	p.V118L	DUSP22_uc011dhn.1_Missense_Mutation_p.V118L|DUSP22_uc003msy.1_Missense_Mutation_p.V75L	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	118	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CCTGCACACCGTGCGTGCTGG	0.597			NA											7	127					8.12818e-05	0.000110582	0.001984	1	0
GMDS	2762	broad.mit.edu	37	6	1742766	1742766	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:1742766C>A	uc003mtq.2	-	8	1016	c.826G>T	c.(826-828)GGG>TGG	p.G276W		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	276					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TGGACCTCCCCAGTAGCTATA	0.448			NA											7	36					8.12818e-05	0.000110582	0.001984	1	0
LY86	9450	broad.mit.edu	37	6	6588981	6588981	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:6588981C>A	uc003mwy.1	+	1	48	c.14C>A	c.(13-15)ACA>AAA	p.T5K	LOC285780_uc003mww.3_Intron|LOC285780_uc003mwx.2_Intron	NM_004271	NP_004262	O95711	LY86_HUMAN	MD-1, RP105-associated precursor	5					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane					0	Ovarian(93;0.0377)					AAGGGTTTCACAGCCACTCTC	0.542			NA											6	75					2.7689e-08	4.68773e-08	0.001984	1	0
ELOVL2	54898	broad.mit.edu	37	6	10989959	10989959	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:10989959G>T	uc003mzp.3	-	7	903	c.742C>A	c.(742-744)CTC>ATC	p.L248I		NM_017770	NP_060240	Q9NXB9	ELOV2_HUMAN	elongation of very long chain fatty acids-like	248	Helical; (Potential).				fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Breast(50;0.0418)|Ovarian(93;0.0919)	all_hematologic(90;0.117)	Epithelial(50;0.176)			TTTAAGAAGAGGATGACTAAC	0.378			NA											9	36					1.12685e-05	1.66247e-05	0.004482	1	0
HIVEP1	3096	broad.mit.edu	37	6	12123583	12123583	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:12123583C>T	uc003nac.2	+	4	3734	c.3555C>T	c.(3553-3555)CAC>CAT	p.H1185H	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1185					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGAAAGTCACCCTTCTCGGG	0.507			NA											6	20					0	0	0.001168	0	0
KDM1B	221656	broad.mit.edu	37	6	18208362	18208362	+	Splice_Site	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:18208362G>T	uc003nco.1	+	10	1258	c.1183_splice	c.e10-1	p.V395_splice	KDM1B_uc003ncn.1_Splice_Site_p.V366_splice	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1						multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						TTTTTGAGCAGGTGCAGTGTA	0.423			NA											12	52					1.08611e-07	1.79074e-07	0.000978	1	0
SLC17A3	10786	broad.mit.edu	37	6	25862555	25862555	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:25862555G>A	uc003nfi.3	-	3	319	c.209C>T	c.(208-210)ACA>ATA	p.T70I	SLC17A3_uc003nfk.3_Missense_Mutation_p.T70I|SLC17A3_uc011djz.1_Missense_Mutation_p.T70I|SLC17A3_uc011dka.1_Missense_Mutation_p.T70I	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	70					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						TTGAGGGCTTGTGCTGTTGAC	0.473			NA											12	46					0	0	0.000978	0	0
OR5V1	81696	broad.mit.edu	37	6	29323886	29323886	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:29323886G>T	uc011dlo.1	-	1	169	c.87C>A	c.(85-87)ACC>ACA	p.T29T		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						GAAAGAAGATGGTGAATAGTA	0.353	Ovarian(32;43 883 21137 32120 42650)		NA											9	71					0.00448238	0.00529312	0.004482	1	0
OR11A1	26531	broad.mit.edu	37	6	29395248	29395248	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:29395248G>T	uc003nmg.2	-	1	262	c.171C>A	c.(169-171)CTC>CTA	p.L57L		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGGTTTGTGGAGCCTCTGGG	0.428			NA											13	43					7.93312e-07	1.24304e-06	0.00245	1	0
RNF39	80352	broad.mit.edu	37	6	30041008	30041008	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:30041008G>A	uc003npe.2	-	3	670	c.608C>T	c.(607-609)TCC>TTC	p.S203F	RNF39_uc003npd.2_Missense_Mutation_p.S203F	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	203						cytoplasm	zinc ion binding				0						AGATGACTTGGATGTTGGGAC	0.473	NSCLC(8;188 360 1520 20207 31481)		NA											7	67					0	0	0.001984	0	0
NOTCH4	4855	broad.mit.edu	37	6	32181560	32181560	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:32181560C>G	uc003obb.2	-	14	2364	c.2225G>C	c.(2224-2226)GGC>GCC	p.G742A	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	742	EGF-like 19.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GTTGCAGGAGCCGCCATTGAG	0.562			NA											5	33					0	0	0.001168	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188027	32188027	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:32188027G>T	uc003obb.2	-	7	1333	c.1194C>A	c.(1192-1194)AGC>AGA	p.S398R	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.S398R	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	398	EGF-like 10.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GGCACGGCTGGCTCAGACACA	0.622			NA											12	33					2.27111e-07	3.68043e-07	0.001368	1	0
PSMB9	5698	broad.mit.edu	37	6	32827219	32827219	+	Silent	SNP	G	G	C	rs145965388		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:32827219G>C	uc003sga.2	+	7	609	c.534G>C	c.(532-534)GGG>GGC	p.G178G		NM_148954	NP_683756	P28065	PSB9_HUMAN	proteasome beta 9 subunit isoform 2 proprotein	190					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0						GCTCAAGCGGGGGTGTCATCT	0.502			NA											38	164					0	0	0.006999	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283189	33283189	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:33283189C>G	uc003oeb.2	-	2	1657	c.1505G>C	c.(1504-1506)CGG>CCG	p.R502P	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.R502P	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	502	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTTCACGTGCCGGTCCCGCAT	0.562			NA											12	96					0	0	0.001368	0	0
TCP11	6954	broad.mit.edu	37	6	35088395	35088395	+	Silent	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:35088395C>T	uc003okd.2	-	7	964	c.783G>A	c.(781-783)CTG>CTA	p.L261L	TCP11_uc003ojz.1_Silent_p.L186L|TCP11_uc003oka.2_Silent_p.L186L|TCP11_uc003okb.2_Silent_p.L185L|TCP11_uc003okc.2_Silent_p.L185L|TCP11_uc011dsu.1_Silent_p.L243L|TCP11_uc011dsv.1_Silent_p.L210L|TCP11_uc011dsw.1_Silent_p.L215L	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	248					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						CTGCTTGGGTCAGCCATTTGG	0.522			NA											6	22					0	0	0.001984	0	0
TREML1	340205	broad.mit.edu	37	6	41117386	41117386	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:41117386C>A	uc011duc.1	-	6	936	c.892G>T	c.(892-894)GGG>TGG	p.G298W	TREML1_uc003opx.2_3'UTR|TREML1_uc011dud.1_Missense_Mutation_p.G187W	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	298	Cytoplasmic (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGGCTGGCCCACACGAGGTC	0.542			NA											5	61					3.59834e-05	5.08422e-05	0.001168	1	0
CD2AP	23607	broad.mit.edu	37	6	47544814	47544814	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:47544814G>C	uc003oyw.2	+	8	1334	c.878G>C	c.(877-879)GGG>GCG	p.G293A		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	293	SH3 3.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TTTAAAGAGGGGGAGATAATC	0.284			NA											4	107					0	0	0.001984	0	0
TFAP2D	83741	broad.mit.edu	37	6	50718983	50718983	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:50718983C>A	uc003paf.2	+	7	1597	c.1085C>A	c.(1084-1086)TCC>TAC	p.S362Y	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	362	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					CTGGGATCCTCCAGACCCACT	0.353			NA											6	23					8.12818e-05	0.000110582	0.001984	1	0
TFAP2B	7021	broad.mit.edu	37	6	50803869	50803869	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:50803869G>T	uc003pag.2	+	4	863	c.697G>T	c.(697-699)GTC>TTC	p.V233F		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	233					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GTTTTGCTCCGTCCCAGGCCG	0.512	Pancreas(116;1373 2332 5475 10752)		NA											13	51					2.27111e-07	3.68043e-07	0.001368	1	0
C6orf142	90523	broad.mit.edu	37	6	54095697	54095697	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:54095697T>A	uc003pcg.3	+	11	1412	c.1299T>A	c.(1297-1299)AGT>AGA	p.S433R	C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Missense_Mutation_p.S968R	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	433						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CCCTCCTCAGTCACAACGCAT	0.468			NA											21	74					0	0	0.008871	0	0
FAM83B	222584	broad.mit.edu	37	6	54805949	54805949	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:54805949G>T	uc003pck.2	+	5	2296	c.2180G>T	c.(2179-2181)AGA>ATA	p.R727I		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	727										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					GTTACCAAGAGAAACTCTCCA	0.393			NA											21	48					1.28384e-07	2.10757e-07	0.001882	1	0
CD109	135228	broad.mit.edu	37	6	74497100	74497100	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:74497100G>T	uc003php.2	+	21	2906	c.2481G>T	c.(2479-2481)CTG>CTT	p.L827L	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Silent_p.L827L|CD109_uc010kba.2_Silent_p.L750L	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	827						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						CAACACATCTGGGAGAAATTC	0.448			NA											7	42					0.00307968	0.00367105	0.00308	1	0
HTR1B	3351	broad.mit.edu	37	6	78172306	78172306	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:78172306G>T	uc003pil.1	-	1	815	c.815C>A	c.(814-816)TCG>TAG	p.S272*		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	272	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GGGAACCCGCGAGTTAATAGA	0.572			NA											11	100					0.00829132	0.00961116	0.008291	1	0
EPHA7	2045	broad.mit.edu	37	6	94120573	94120574	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:94120573_94120574GG>TT	uc003poe.2	-	3	718_719	c.477_478CC>AA	c.(475-480)GACCTT>GAAATT	p.159_160DL>EI	EPHA7_uc003pof.2_Missense_Mutation_p.159_160DL>EI|EPHA7_uc011eac.1_Missense_Mutation_p.159_160DL>EI|EPHA7_uc003pog.3_Missense_Mutation_p.159_160DL>EI	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	159_160	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTTTCACCAAGGTCACCTTGGG	0.401			NA											5	80					0	0	0.004672	0	0
DDO	8528	broad.mit.edu	37	6	110714247	110714247	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:110714247C>A	uc003puc.2	-	5	845	c.841G>T	c.(841-843)GAG>TAG	p.E281*	C6orf186_uc003pub.2_Intron|DDO_uc003pud.2_Nonsense_Mutation_p.E222*	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	253					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GAAAGAATCTCTCTGCTATTT	0.547			NA											16	123					4.14922e-12	7.76526e-12	0.004007	1	0
DCBLD1	285761	broad.mit.edu	37	6	117825053	117825053	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:117825053G>T	uc003pxs.2	+	2	361	c.236G>T	c.(235-237)AGA>ATA	p.R79I	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Missense_Mutation_p.R79I	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	79	CUB.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		AAGGGGAAAAGACTGATTCTG	0.423			NA											16	58					3.41278e-10	6.12468e-10	0.00499	1	0
SAMD3	154075	broad.mit.edu	37	6	130465706	130465706	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:130465706C>A	uc003qbv.2	-	13	1848	c.1522G>T	c.(1522-1524)GAA>TAA	p.E508*	SAMD3_uc003qbx.2_Nonsense_Mutation_p.E508*|SAMD3_uc003qbw.2_Nonsense_Mutation_p.E508*	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	508										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TTTTCCTTTTCTTTCAAAGAA	0.373			NA											5	35					0.000602214	0.000754262	0.000602	1	0
CITED2	10370	broad.mit.edu	37	6	139695015	139695015	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:139695015G>A	uc003qip.1	-	2	311	c.67C>T	c.(67-69)CAC>TAC	p.H23Y		NM_006079	NP_006070	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with	23	His-rich.				adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity				0	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		TGGGCAGGGTGATGGTGCAGC	0.612	NSCLC(98;1219 1550 33720 43229 49330)		NA											30	182					0	0	0.008361	0	0
CITED2	10370	broad.mit.edu	37	6	139695043	139695043	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:139695043G>A	uc003qip.1	-	2	283	c.39C>T	c.(37-39)TTC>TTT	p.F13F		NM_006079	NP_006070	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with	13					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity				0	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		TGCCGTCGGGGAAGCGCCCGT	0.637	NSCLC(98;1219 1550 33720 43229 49330)		NA											26	161					0	0	0.004656	0	0
FBXO30	84085	broad.mit.edu	37	6	146126130	146126130	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:146126130C>G	uc003qla.2	-	2	1611	c.1412G>C	c.(1411-1413)AGT>ACT	p.S471T	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	471							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		AACCATTGTACTTGTAGCTAA	0.448			NA											12	93					0	0	0.001855	0	0
GRM1	2911	broad.mit.edu	37	6	146720217	146720217	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:146720217G>T	uc010khw.1	+	8	2512	c.2042G>T	c.(2041-2043)CGT>CTT	p.R681L	GRM1_uc010khv.1_Missense_Mutation_p.R681L|GRM1_uc003qll.2_Missense_Mutation_p.R681L|GRM1_uc011edz.1_Missense_Mutation_p.R681L|GRM1_uc011eea.1_Missense_Mutation_p.R681L	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	681	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AAAACCAATCGTATTGCACGC	0.527			NA											29	123					7.38237e-10	1.31448e-09	0.00632	1	0
SYNE1	23345	broad.mit.edu	37	6	152720814	152720814	+	Missense_Mutation	SNP	C	C	A	rs146099481	by1000genomes	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:152720814C>A	uc010kiw.2	-	48	7776	c.7174G>T	c.(7174-7176)GTG>TTG	p.V2392L	SYNE1_uc003qot.3_Missense_Mutation_p.V2399L|SYNE1_uc003qou.3_Missense_Mutation_p.V2392L|SYNE1_uc010kjb.1_Missense_Mutation_p.V2375L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2392	Spectrin 3.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AACTGGCTCACGGCTTCATGT	0.498			NA								HNSCC(10;0.0054)			26	127					4.26978e-12	7.96464e-12	0.00333	1	0
PDE10A	10846	broad.mit.edu	37	6	165801923	165801923	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:165801923G>T	uc003qun.2	-	18	1887	c.1646C>A	c.(1645-1647)GCG>GAG	p.A549E	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.A479E|PDE10A_uc003quo.2_Missense_Mutation_p.A559E	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	549					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	ACACAGACACGCAATCAGCAG	0.483	Esophageal Squamous(22;308 615 5753 12038 40624)		NA											9	61					3.09899e-07	4.96537e-07	0.004482	1	0
TTLL2	83887	broad.mit.edu	37	6	167753613	167753613	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:167753613G>A	uc003qvs.1	+	3	313	c.225G>A	c.(223-225)GCG>GCA	p.A75A	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	75					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ATTTGATGGCGGAAGATGAAC	0.507			NA											11	53					0	0	0.000978	0	0
FTSJ2	29960	broad.mit.edu	37	7	2279214	2279214	+	Missense_Mutation	SNP	G	G	A	rs150856697		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:2279214G>A	uc003slm.2	-	2	166	c.137C>T	c.(136-138)GCT>GTT	p.A46V	FTSJ2_uc003slk.2_5'UTR|FTSJ2_uc003sll.2_5'UTR|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_5'UTR|NUDT1_uc003slp.1_5'Flank|NUDT1_uc003slq.1_5'Flank|NUDT1_uc003slr.1_5'Flank|NUDT1_uc003sls.1_5'Flank|NUDT1_uc003slt.1_5'Flank	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	46					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		CACCTTCGCAGCCTTCACAAA	0.597			NA											4	90					0	0	0.000602	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6089666	6089666	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:6089666C>G	uc003spp.2	-	3	434	c.288G>C	c.(286-288)CAG>CAC	p.Q96H	EIF2AK1_uc003spq.2_Missense_Mutation_p.Q96H|EIF2AK1_uc011jwm.1_Intron	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	96					negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TGATAAACGTCTGGCAAAGTA	0.318			NA											6	41					0	0	0.001984	0	0
DGKB	1607	broad.mit.edu	37	7	14613905	14613905	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:14613905T>C	uc003ssz.2	-	19	1892	c.1705A>G	c.(1705-1707)AAT>GAT	p.N569D	DGKB_uc011jxt.1_Missense_Mutation_p.N550D|DGKB_uc003sta.2_Missense_Mutation_p.N569D|DGKB_uc011jxu.1_Missense_Mutation_p.N568D	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	569					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TCTTTGTCATTAGGTATGACT	0.378			NA											25	122					0	0	0.00333	0	0
ABCB5	340273	broad.mit.edu	37	7	20738036	20738036	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:20738036C>A	uc003suw.3	+	8	1228	c.682C>A	c.(682-684)CTT>ATT	p.L228I	ABCB5_uc010kuh.2_Missense_Mutation_p.L673I	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	228	Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TTAGATAAGTCTTCCTGAAGT	0.323			NA											7	43					0.00198382	0.00238984	0.001984	1	0
ABCB5	340273	broad.mit.edu	37	7	20793064	20793064	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:20793064C>A	uc003suw.3	+	18	2722	c.2176C>A	c.(2176-2178)CTC>ATC	p.L726I	ABCB5_uc010kuh.2_Missense_Mutation_p.L1171I	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	726	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AAGGGCTCTTCTCCAAAAACC	0.408			NA											9	55					5.4927e-09	9.52628e-09	0.004482	1	0
FAM126A	84668	broad.mit.edu	37	7	22985289	22985289	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:22985289T>A	uc003svm.3	-	11	1740	c.1485A>T	c.(1483-1485)TCA>TCT	p.S495S	FAM126A_uc003svn.3_3'UTR	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	495						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						CAGTTCTTTCTGAAACGTAAA	0.418			NA											20	81					0	0	0.001523	0	0
C7orf31	136895	broad.mit.edu	37	7	25194712	25194712	+	Silent	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:25194712C>G	uc003sxn.1	-	6	1074	c.513G>C	c.(511-513)ACG>ACC	p.T171T	C7orf31_uc003sxm.1_Silent_p.T13T	NM_138811	NP_620166	Q8N865	CG031_HUMAN	hypothetical protein LOC136895	171											0						CTTTAATGCCCGTGTAGAGGT	0.527			NA											4	30					0	0	0.000602	0	0
CPVL	54504	broad.mit.edu	37	7	29070193	29070193	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:29070193C>G	uc003szv.2	-	12	1439	c.1320G>C	c.(1318-1320)CAG>CAC	p.Q440H	CPVL_uc003szw.2_Missense_Mutation_p.Q440H|CPVL_uc003szx.2_Missense_Mutation_p.Q440H	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	440					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						ATCTTCCTACCTGATGGAAGT	0.473			NA											12	129					0	0	0.00245	0	0
PDE1C	5137	broad.mit.edu	37	7	31913022	31913022	+	Splice_Site	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:31913022C>A	uc003tcm.1	-	6	962	c.493_splice	c.e6-1	p.D165_splice	PDE1C_uc003tcn.1_Splice_Site_p.D165_splice|PDE1C_uc003tco.1_Splice_Site_p.D225_splice|PDE1C_uc003tcr.2_Splice_Site_p.D165_splice|PDE1C_uc003tcs.2_Splice_Site_p.D165_splice	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C						activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TGTCCACATCCTGCAGGACAG	0.488			NA											7	25					8.12818e-05	0.000110582	0.001984	1	0
PDE1C	5137	broad.mit.edu	37	7	32209517	32209517	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:32209517C>A	uc003tco.1	-	3	782	c.188G>T	c.(187-189)GGG>GTG	p.G63V		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CTTGACATTCCCTGTGAGCCC	0.522			NA											13	77					1.61879e-10	2.9236e-10	0.001368	1	0
DPY19L2P1	554236	broad.mit.edu	37	7	35144292	35144292	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:35144292G>T	uc003teq.1	-	18	1923	c.816C>A	c.(814-816)CAC>CAA	p.H272Q	DPY19L2P1_uc003tep.1_RNA|DPY19L2P1_uc010kwz.1_RNA					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						TAACACACATGTGCAGCGTCA	0.363			NA											3	30					0.004672	0.00544907	0.004672	1	0
ANLN	54443	broad.mit.edu	37	7	36463494	36463494	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:36463494G>C	uc003tff.2	+	15	2749	c.2545G>C	c.(2545-2547)GCA>CCA	p.A849P	ANLN_uc011kaz.1_Missense_Mutation_p.A761P|ANLN_uc003tfg.2_Missense_Mutation_p.A812P|ANLN_uc010kxe.2_Missense_Mutation_p.A811P	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	849	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						CACACCATTAGCAAGTACTTC	0.333			NA											12	59					0	0	0.000978	0	0
TXNDC3	51314	broad.mit.edu	37	7	37890007	37890007	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:37890007G>A	uc003tfn.2	+	4	433	c.61G>A	c.(61-63)GAT>AAT	p.D21N		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	21	Thioredoxin.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AAGCCTGTGGGATGAGATGTT	0.493	Ovarian(108;903 1537 27096 29907 47400)		NA							Kartagener_syndrome				26	116					0	0	0.005443	0	0
AMPH	273	broad.mit.edu	37	7	38530667	38530667	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:38530667G>C	uc003tgu.2	-	5	448	c.379C>G	c.(379-381)CAA>GAA	p.Q127E	AMPH_uc003tgv.2_Missense_Mutation_p.Q127E	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	127	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TCAGGAAATTGCCCCAGGTAG	0.403			NA											22	145					0	0	0.00278	0	0
GLI3	2737	broad.mit.edu	37	7	42005086	42005086	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:42005086G>A	uc011kbh.1	-	15	3676	c.3585C>T	c.(3583-3585)AAC>AAT	p.N1195N	GLI3_uc011kbg.1_Silent_p.N1136N	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1195					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CGACCATGCCGTTGCAGAACC	0.667			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				8	104					0	0	0.004482	0	0
SPDYE1	285955	broad.mit.edu	37	7	44046939	44046939	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:44046939G>A	uc003tjf.2	+	5	841	c.705G>A	c.(703-705)AAG>AAA	p.K235K	POLR2J4_uc003tjc.2_Intron|POLR2J4_uc003tjd.2_Intron|POLR2J4_uc010kxw.2_Intron|POLR2J4_uc003tje.3_Intron|uc003tjg.1_Intron	NM_175064	NP_778234	Q8NFV5	SPDE1_HUMAN	Williams Beuren syndrome chromosome region 19	235										ovary(1)	1						TGTATGGGAAGAACCGCTCTC	0.542			NA											24	158					0	0	0.00333	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44801092	44801092	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:44801092G>T	uc003tlr.2	+	10	1408	c.1285G>T	c.(1285-1287)GAT>TAT	p.D429Y	ZMIZ2_uc003tlq.2_Missense_Mutation_p.D371Y|ZMIZ2_uc003tls.2_Missense_Mutation_p.D403Y|ZMIZ2_uc003tlt.2_Missense_Mutation_p.D52Y|ZMIZ2_uc010kyj.2_5'UTR	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	429					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CCCTGTGCGCGATGGGGTGGT	0.612	NSCLC(20;604 852 1948 16908 50522)		NA											11	38					5.16669e-11	9.4667e-11	0.000978	1	0
SUN3	256979	broad.mit.edu	37	7	48068523	48068523	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:48068523T>A	uc003tof.2	-	2	110	c.13A>T	c.(13-15)ACA>TCA	p.T5S	SUN3_uc003tog.2_Missense_Mutation_p.T5S|SUN3_uc011kcf.1_5'UTR	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	5						integral to membrane				central_nervous_system(1)	1						CTTGCCTTTGTTTTTCCACTC	0.433			NA											14	51					0	0	0.003163	0	0
UPP1	7378	broad.mit.edu	37	7	48142961	48142961	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:48142961G>T	uc003toj.2	+	7	918	c.389G>T	c.(388-390)CGG>CTG	p.R130L	UPP1_uc003tok.2_Missense_Mutation_p.R130L|UPP1_uc003tol.2_Missense_Mutation_p.R130L|UPP1_uc011kcg.1_Missense_Mutation_p.R130L|UPP1_uc011kch.1_Intron|UPP1_uc003ton.2_Intron|UPP1_uc003too.2_Intron	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	130					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						TACTATGCCCGGTGCTCCAAC	0.522			NA											12	74					0.000219431	0.000293264	0.00245	1	0
POM121L12	285877	broad.mit.edu	37	7	53103455	53103455	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:53103455G>T	uc003tpz.2	+	1	107	c.91G>T	c.(91-93)GCT>TCT	p.A31S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	31											0						CGCCCTGGCGGCTCCCATGAG	0.687			NA											5	25					0.000602214	0.000754262	0.000602	1	0
HGF	3082	broad.mit.edu	37	7	81334976	81334976	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:81334976C>A	uc003uhl.2	-	16	2016	c.1851G>T	c.(1849-1851)TGG>TGT	p.W617C	HGF_uc003uhm.2_Missense_Mutation_p.W612C	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	617	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CAGTGTAGCCCCAGCCATAAA	0.353			NA											4	56					0.00024832	0.000325365	0.000248	1	0
CACNA2D1	781	broad.mit.edu	37	7	81588610	81588610	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:81588610C>A	uc003uhr.1	-	38	3396	c.3140G>T	c.(3139-3141)TGC>TTC	p.C1047F	CACNA2D1_uc011kgy.1_Missense_Mutation_p.C259F	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	1059	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GTTATCAAAGCAGACATCAGG	0.373			NA											6	60					8.12818e-05	0.000110582	0.001984	1	0
CACNA2D1	781	broad.mit.edu	37	7	81589101	81589101	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:81589101A>G	uc003uhr.1	-	37	3267	c.3011T>C	c.(3010-3012)ATA>ACA	p.I1004T	CACNA2D1_uc011kgy.1_Missense_Mutation_p.I216T	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	1016	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTCAACCATTATGAATATTAA	0.363			NA											6	35					0	0	0.001984	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965207	88965207	+	Missense_Mutation	SNP	G	G	C	rs141578416		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:88965207G>C	uc011khi.1	+	4	3449	c.2911G>C	c.(2911-2913)GGC>CGC	p.G971R		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	971						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGCACCATCAGGCTGTAACAG	0.403			NA								HNSCC(36;0.09)			4	92					0	0	0.000248	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92838067	92838067	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:92838067A>T	uc003umm.2	-	4	861	c.838T>A	c.(838-840)TAC>AAC	p.Y280N	HEPACAM2_uc003uml.2_Missense_Mutation_p.Y268N|HEPACAM2_uc010lff.2_Missense_Mutation_p.Y268N|HEPACAM2_uc011khy.1_Missense_Mutation_p.Y303N	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	280	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						ATCCAGGAGTAGGTGTTGGGG	0.438			NA											16	47					0	0	0.003163	0	0
C7orf51	222950	broad.mit.edu	37	7	100086049	100086049	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:100086049T>C	uc003uvd.1	+	4	864	c.705T>C	c.(703-705)GCT>GCC	p.A235A	C7orf51_uc003uve.1_Silent_p.A17A	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	235										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAGGCCTGGCTGGGCCCCCTC	0.637			NA											9	29					0	0	0.008291	0	0
ZAN	7455	broad.mit.edu	37	7	100352909	100352909	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:100352909C>A	uc003uwj.2	+	15	3350	c.3185C>A	c.(3184-3186)CCC>CAC	p.P1062H	ZAN_uc003uwk.2_Missense_Mutation_p.P1062H|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1062	TIL 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCAAGAGCCCCAGGCCTAGC	0.567			NA											8	122					0.000157383	0.000211083	0.00308	1	0
MUC17	140453	broad.mit.edu	37	7	100677732	100677732	+	Missense_Mutation	SNP	C	C	A	rs150736052		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:100677732C>A	uc003uxp.1	+	3	3088	c.3035C>A	c.(3034-3036)ACT>AAT	p.T1012N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1012	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|15.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GACTCCAACACTCCTTTGACC	0.507			NA											22	259					1.87028e-06	2.89855e-06	0.001882	1	0
MUC17	140453	broad.mit.edu	37	7	100684017	100684017	+	Nonsense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:100684017T>A	uc003uxp.1	+	3	9373	c.9320T>A	c.(9319-9321)TTA>TAA	p.L3107*	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3107	Extracellular (Potential).|Ser-rich.|50.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCACTCCATTAACAGGTGTG	0.493			NA											37	237					0	0	0.00874	0	0
PLOD3	8985	broad.mit.edu	37	7	100850973	100850973	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:100850973C>A	uc003uyd.2	-	17	2277	c.1821G>T	c.(1819-1821)GTG>GTT	p.V607V	PLOD3_uc010lhs.2_Silent_p.V172V	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	607					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	CCACGGTGGGCACATTCTCGT	0.537			NA											4	31					2.56e-06	3.89312e-06	0.000248	1	0
DPY19L2P2	349152	broad.mit.edu	37	7	102825936	102825936	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:102825936G>C	uc003vbh.3	-	20	3250	c.1059C>G	c.(1057-1059)GTC>GTG	p.V353V	DPY19L2P2_uc003vbg.3_RNA|DPY19L2P2_uc010lit.2_RNA	NR_003561				RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						ATGAAGTGTAGACAGCTTGAC	0.388			NA											8	19					0	0	0.006214	0	0
RELN	5649	broad.mit.edu	37	7	103244895	103244895	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:103244895T>A	uc003vca.2	-	23	3204	c.3044A>T	c.(3043-3045)TAT>TTT	p.Y1015F	RELN_uc010liz.2_Missense_Mutation_p.Y1015F	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1015					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCTGTGTAATAGCTCTGGCT	0.493	NSCLC(146;835 1944 15585 22231 52158)		NA											7	51					0	0	0.00308	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508290	106508290	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:106508290A>T	uc003vdv.3	+	2	369	c.284A>T	c.(283-285)CAC>CTC	p.H95L	PIK3CG_uc003vdu.2_Missense_Mutation_p.H95L|PIK3CG_uc003vdw.2_Missense_Mutation_p.H95L	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	95					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GGACCGCATCACTTCCTCCTG	0.632			NA											8	32					0	0	0.004482	0	0
LAMB1	3912	broad.mit.edu	37	7	107580556	107580556	+	Silent	SNP	G	G	T	rs141885441		TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:107580556G>T	uc003vew.2	-	25	3974	c.3639C>A	c.(3637-3639)ATC>ATA	p.I1213I	LAMB1_uc003vev.2_Silent_p.I1237I	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1213	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTAAGGCCCGATCACACCAC	0.537			NA											11	85					6.40141e-05	8.8683e-05	0.000978	1	0
TFEC	22797	broad.mit.edu	37	7	115580691	115580691	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:115580691G>T	uc003vhj.1	-	8	1142	c.958C>A	c.(958-960)CCT>ACT	p.P320T	TFEC_uc003vhk.1_Missense_Mutation_p.P291T|TFEC_uc003vhl.3_3'UTR|TFEC_uc011kmw.1_3'UTR	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	320	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			GATAGCAGAGGATCTGTTCCA	0.403			NA											14	77					0.00185496	0.00226098	0.001855	1	0
ST7	7982	broad.mit.edu	37	7	116869863	116869863	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:116869863G>T	uc011knn.1	+	14	1395	c.1390G>T	c.(1390-1392)GGA>TGA	p.G464*	ST7_uc003vio.2_Silent_p.V539V|ST7_uc003viq.2_Silent_p.V516V|ST7_uc011knm.1_Silent_p.V519V|ST7_uc003vir.2_Silent_p.V482V	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TGGAGAAAGTGGAGAGCATCC	0.522			NA											41	193					3.56509e-09	6.24027e-09	0.002852	1	0
ASZ1	136991	broad.mit.edu	37	7	117067454	117067454	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:117067454C>T	uc003vjb.2	-	1	124	c.61G>A	c.(61-63)GAG>AAG	p.E21K	ASZ1_uc011kno.1_Missense_Mutation_p.E21K|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	21					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CCATCATCCTCGCTCTCGCTA	0.672			NA									OREG0003439	type=REGULATORY REGION|Gene=ASZ1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	49					0	0	0.000602	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121612652	121612652	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:121612652T>A	uc003vjy.2	+	4	757	c.362T>A	c.(361-363)TTT>TAT	p.F121Y	PTPRZ1_uc003vjz.2_Missense_Mutation_p.F121Y	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	121	Extracellular (Potential).|Alpha-carbonic anhydrase.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GAAATGGTGTTTAAAGCAAGC	0.358			NA											11	61					0	0	0.008291	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650794	121650794	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:121650794T>C	uc003vjy.2	+	12	2089	c.1694T>C	c.(1693-1695)ATA>ACA	p.I565T	PTPRZ1_uc003vjz.2_Missense_Mutation_p.I565T|PTPRZ1_uc011knt.1_Missense_Mutation_p.I15T	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	565	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACAGTTTCTATAACAGAATAT	0.418			NA											5	48					0	0	0.001168	0	0
RBM28	55131	broad.mit.edu	37	7	127970895	127970895	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:127970895T>C	uc003vmp.2	-	10	1221	c.1106A>G	c.(1105-1107)CAT>CGT	p.H369R	RBM28_uc003vmo.2_5'UTR|RBM28_uc011koj.1_Missense_Mutation_p.H228R|RBM28_uc011kok.1_Missense_Mutation_p.H316R	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	369	RRM 3.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TGTGTCTGGATGCAAGACAAT	0.468			NA											4	58					0	0	0.000248	0	0
FLNC	2318	broad.mit.edu	37	7	128492994	128492994	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:128492994G>A	uc003vnz.3	+	37	6326	c.6117G>A	c.(6115-6117)GGG>GGA	p.G2039G	FLNC_uc003voa.3_Silent_p.G2006G	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2039	Filamin 19.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CTGAGATCGGGGACGCCAGCA	0.622			NA											3	39					0	0	0.004672	0	0
CPA1	1357	broad.mit.edu	37	7	130023602	130023602	+	Silent	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:130023602C>G	uc003vpx.2	+	6	735	c.663C>G	c.(661-663)ACC>ACG	p.T221T	CPA1_uc011kpf.1_Silent_p.T133T|CPA1_uc003vpw.2_Intron	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	221					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AGATCGTCACCAACCCTGATG	0.572			NA											6	56					0	0	0.004482	0	0
CALD1	800	broad.mit.edu	37	7	134632491	134632491	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:134632491G>C	uc003vrz.2	+	8	2224	c.1765G>C	c.(1765-1767)GAG>CAG	p.E589Q	CALD1_uc003vry.2_Missense_Mutation_p.E334Q|CALD1_uc003vsa.2_Missense_Mutation_p.E360Q|CALD1_uc003vsb.2_Missense_Mutation_p.E334Q|CALD1_uc010lmm.2_Missense_Mutation_p.E360Q|CALD1_uc011kpt.1_Missense_Mutation_p.E108Q|CALD1_uc003vsc.2_Missense_Mutation_p.E354Q|CALD1_uc003vsd.2_Missense_Mutation_p.E328Q|CALD1_uc011kpu.1_Missense_Mutation_p.E339Q|CALD1_uc011kpv.1_Missense_Mutation_p.E198Q|CALD1_uc003vse.2_Missense_Mutation_p.E453Q	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	589	Tropomyosin-binding (Potential).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						gaggaagcaggaggaagCCGA	0.274			NA											5	16					0	0	0.001168	0	0
NUP205	23165	broad.mit.edu	37	7	135290944	135290944	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:135290944G>T	uc003vsw.2	+	20	2906	c.2875G>T	c.(2875-2877)GAT>TAT	p.D959Y		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	959					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GGATTGTGAAGATGCAGAAGA	0.323			NA											9	94					6.40141e-05	8.8683e-05	0.000978	1	0
CLCN1	1180	broad.mit.edu	37	7	143016969	143016969	+	Splice_Site	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:143016969G>C	uc003wcr.1	+	2	388	c.301_splice	c.e2+1	p.D101_splice	CLCN1_uc011ktc.1_Splice_Site|CLCN1_uc003wcs.1_5'Flank|CLCN1_uc010lox.1_5'Flank|CLCN1_uc010loy.1_5'Flank	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle						muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					AAATGTCAAGGTGATGGGGAC	0.488			NA											20	74					0	0	0.002299	0	0
TPK1	27010	broad.mit.edu	37	7	144245644	144245644	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:144245644G>T	uc003weq.2	-	8	656	c.553C>A	c.(553-555)CTT>ATT	p.L185I	TPK1_uc003weo.2_Missense_Mutation_p.L131I|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Missense_Mutation_p.L136I|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	185					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	ACAGGAATAAGGCCACACCAA	0.428	Ovarian(45;88 1034 2073 5829 28455)		NA											14	76					1.99824e-07	3.27089e-07	0.00499	1	0
ZNF425	155054	broad.mit.edu	37	7	148802491	148802491	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:148802491C>A	uc003wfj.2	-	4	545	c.472G>T	c.(472-474)GTC>TTC	p.V158F		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	158					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GTGATGCTGACTTTTTTATTT	0.473			NA											9	106					5.4927e-09	9.52628e-09	0.004482	1	0
GIMAP8	155038	broad.mit.edu	37	7	150167962	150167962	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:150167962G>C	uc003whj.2	+	3	1012	c.682G>C	c.(682-684)GGC>CGC	p.G228R		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	228						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAAGCCACAGGGTAAGTTGAT	0.378			NA											3	23					0	0	0.000248	0	0
ABCB8	11194	broad.mit.edu	37	7	150731593	150731593	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:150731593G>T	uc003wil.3	+	5	710	c.617G>T	c.(616-618)GGA>GTA	p.G206V	ABCB8_uc003wii.2_Missense_Mutation_p.G226V|ABCB8_uc003wij.3_Missense_Mutation_p.G189V|ABCB8_uc010lpw.1_Missense_Mutation_p.G8V|ABCB8_uc010lpx.2_Missense_Mutation_p.G189V|ABCB8_uc011kvd.1_Missense_Mutation_p.G101V|ABCB8_uc003wim.3_5'UTR|ABCB8_uc003wik.3_Missense_Mutation_p.G189V	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	206	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTTCGCAGGGACTGCTGACC	0.652			NA											13	96					1.05317e-09	1.86355e-09	0.00245	1	0
MLL3	58508	broad.mit.edu	37	7	151904477	151904477	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:151904477G>T	uc003wla.2	-	24	3968	c.3749C>A	c.(3748-3750)TCT>TAT	p.S1250Y	MLL3_uc003wkz.2_Missense_Mutation_p.S311Y	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1250					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTCAGGACTAGATTCTGATTT	0.373	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								8	56					0.000442599	0.000568128	0.006214	1	0
UBE3C	9690	broad.mit.edu	37	7	156963050	156963050	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:156963050G>C	uc010lqs.2	+	4	560	c.248G>C	c.(247-249)GGG>GCG	p.G83A	UBE3C_uc003wnf.2_Missense_Mutation_p.G40A|UBE3C_uc003wng.2_Missense_Mutation_p.G83A	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	83					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TCACAGTCCGGGGGCGCTTTT	0.408			NA											18	88					0	0	0.001523	0	0
RP1L1	94137	broad.mit.edu	37	8	10468702	10468702	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:10468702A>T	uc003wtc.2	-	4	3135	c.2906T>A	c.(2905-2907)ATA>AAA	p.I969K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	969					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGTCATGAGTATGGGCTCTTC	0.627			NA											9	80					0	0	0.004482	0	0
LPL	4023	broad.mit.edu	37	8	19805777	19805777	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:19805777G>A	uc003wzk.3	+	2	545	c.175G>A	c.(175-177)GGA>AGA	p.G59R		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	59					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	CCTCATTCCCGGAGTAGCAGA	0.483			NA											3	51					0	0	0.000248	0	0
TEX15	56154	broad.mit.edu	37	8	30702509	30702509	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:30702509A>T	uc003xil.2	-	1	4025	c.4025T>A	c.(4024-4026)GTG>GAG	p.V1342E		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1342										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ACTATCTGTCACTGCAGCGGC	0.383			NA											11	63					0	0	0.008291	0	0
TEX15	56154	broad.mit.edu	37	8	30702944	30702944	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:30702944G>T	uc003xil.2	-	1	3590	c.3590C>A	c.(3589-3591)TCT>TAT	p.S1197Y		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1197										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ACTAGTGCTAGATAAAAATGC	0.313			NA											3	21					6.4e-05	8.8683e-05	0.004672	1	0
NRG1	3084	broad.mit.edu	37	8	32621438	32621438	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:32621438G>T	uc003xiv.2	+	12	1958	c.1441G>T	c.(1441-1443)GTG>TTG	p.V481L	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiu.2_Missense_Mutation_p.V486L|NRG1_uc003xiw.2_Missense_Mutation_p.V478L|NRG1_uc003xit.2_3'UTR|NRG1_uc010lvr.2_Missense_Mutation_p.V223L|NRG1_uc010lvs.2_Missense_Mutation_p.V223L|NRG1_uc010lvp.2_Missense_Mutation_p.V435L|NRG1_uc010lvq.2_Missense_Mutation_p.V418L|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Missense_Mutation_p.V324L|NRG1_uc003xja.2_Missense_Mutation_p.V292L	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	481	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TCTACTTCTCGTGACACCACC	0.582			NA											5	28					1.23904e-05	1.80687e-05	0.000602	1	0
PROSC	11212	broad.mit.edu	37	8	37633506	37633508	+	Missense_Mutation	TNP	TGG	TGG	ATT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	TGG	TGG	-	-	TGG	TGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:37633506_37633508TGG>ATT	uc003xkh.2	+	7	745_747	c.668_670TGG>ATT	c.(667-672)ATGGGC>AATTGC	p.223_224MG>NC		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	223_224							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	GAGCTGAGCATGGGCATGTCCGC	0.562			NA											5	80					0	0	0.004672	0	0
ADAM9	8754	broad.mit.edu	37	8	38913229	38913229	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:38913229C>A	uc003xmr.2	+	14	1607	c.1529C>A	c.(1528-1530)GCC>GAC	p.A510D	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA|ADAM9_uc003xms.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	510	Cys-rich.|Extracellular (Potential).				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			AATAACAAAGCCTATTGCTAC	0.383			NA											5	58					0.00116845	0.00142726	0.001168	1	0
MYST3	7994	broad.mit.edu	37	8	41836297	41836297	+	Splice_Site	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:41836297T>A	uc010lxb.2	-	7	1452	c.908_splice	c.e7-1	p.G303_splice	MYST3_uc010lxc.2_Splice_Site_p.G303_splice|MYST3_uc003xon.3_Splice_Site_p.G303_splice|MYST3_uc010lxd.2_Splice_Site_p.G303_splice	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic						histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TCCACATGCCTATAAAAAAAT	0.303			NA											5	58					0	0	0.000602	0	0
CHRNA6	8973	broad.mit.edu	37	8	42611334	42611334	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:42611334T>A	uc003xpj.2	-	5	1054	c.1008A>T	c.(1006-1008)ACA>ACT	p.T336T	CHRNA6_uc011lcw.1_Silent_p.T321T	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	336	Cytoplasmic.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ACCTGGGCATTGTGTGCGTGG	0.547			NA											5	37					0	0	0.000602	0	0
PXDNL	137902	broad.mit.edu	37	8	52320839	52320839	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:52320839G>C	uc003xqu.3	-	17	3446	c.3345C>G	c.(3343-3345)TCC>TCG	p.S1115S	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1115					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGAGAAGGTAGGAGGGTGCCC	0.572			NA											5	74					0	0	0.000602	0	0
PXDNL	137902	broad.mit.edu	37	8	52384864	52384864	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:52384864T>C	uc003xqu.3	-	8	796	c.695A>G	c.(694-696)CAG>CGG	p.Q232R		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	232	LRRCT.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCGGGGGCTCTCTGCAACAAA	0.413			NA											3	40					0	0	0.004672	0	0
RP1	6101	broad.mit.edu	37	8	55542651	55542651	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:55542651A>G	uc003xsd.1	+	4	6357	c.6209A>G	c.(6208-6210)AAC>AGC	p.N2070S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2070					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GAGAATAACAACTTATTAAAT	0.358	Colon(91;1014 1389 7634 14542 40420)		NA											6	29					0	0	0.001984	0	0
ARMC1	55156	broad.mit.edu	37	8	66517566	66517566	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:66517566C>A	uc003xvl.2	-	6	824	c.589G>T	c.(589-591)GCA>TCA	p.A197S	ARMC1_uc011leo.1_Missense_Mutation_p.A95S	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	197					metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			ATTGCTGATGCCAAAGCCTAA	0.333			NA											11	42					7.03913e-09	1.21342e-08	0.001368	1	0
ADHFE1	137872	broad.mit.edu	37	8	67361160	67361160	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:67361160A>T	uc003xwb.3	+	8	723	c.689A>T	c.(688-690)CAC>CTC	p.H230L	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.H182L|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_RNA|ADHFE1_uc011les.1_Missense_Mutation_p.H160L|ADHFE1_uc011leq.1_RNA|ADHFE1_uc011ler.1_RNA	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	230					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			CACACCCTCCACATGCCTGCC	0.507			NA											20	135					0	0	0.002299	0	0
MSC	9242	broad.mit.edu	37	8	72754953	72754953	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:72754953C>A	uc003xyx.1	-	2	882	c.564G>T	c.(562-564)CCG>CCT	p.P188P	uc011lff.1_5'Flank|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	188					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			TGTCAGAGTCCGGTCTTCCCG	0.463			NA											25	274					3.65163e-15	7.03093e-15	0.00632	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766690	77766690	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:77766690C>A	uc003yav.2	+	10	7785	c.7398C>A	c.(7396-7398)CAC>CAA	p.H2466Q	ZFHX4_uc003yau.1_Missense_Mutation_p.H2511Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.H2466Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2466	C2H2-type 16.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GGCAGGAACACCAGCACATGC	0.483			NA								HNSCC(33;0.089)			7	110					0.000157383	0.000211083	0.00308	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766734	77766734	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:77766734C>G	uc003yav.2	+	10	7829	c.7442C>G	c.(7441-7443)TCT>TGT	p.S2481C	ZFHX4_uc003yau.1_Missense_Mutation_p.S2526C|ZFHX4_uc003yaw.1_Missense_Mutation_p.S2481C	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2481						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCCTTCACTCTCCGTTCTTG	0.498			NA								HNSCC(33;0.089)			6	105					0	0	0.001168	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767190	77767190	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:77767190C>A	uc003yav.2	+	10	8285	c.7898C>A	c.(7897-7899)CCG>CAG	p.P2633Q	ZFHX4_uc003yau.1_Missense_Mutation_p.P2678Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.P2633Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2633	C2H2-type 17.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAACGGTGTCCGTTTTGCCGA	0.542			NA								HNSCC(33;0.089)			6	32					0.00116845	0.00142726	0.001168	1	0
ZFHX4	79776	broad.mit.edu	37	8	77775744	77775744	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:77775744A>T	uc003yav.2	+	11	10046	c.9659A>T	c.(9658-9660)TAC>TTC	p.Y3220F		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3216						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCTTGCCATACTTTATCCCT	0.488			NA								HNSCC(33;0.089)			6	101					0	0	0.001984	0	0
CA3	761	broad.mit.edu	37	8	86354332	86354332	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:86354332A>T	uc003ydj.2	+	3	346	c.263A>T	c.(262-264)TAC>TTC	p.Y88F	CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	88					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						CCTGGACCCTACCGACTTCGC	0.502			NA											12	52					0	0	0.000978	0	0
CNGB3	54714	broad.mit.edu	37	8	87588160	87588161	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:87588160_87588161GG>AT	uc003ydx.2	-	18	2347_2348	c.2301_2302CC>AT	c.(2299-2304)CCCCAC>CCATAC	p.H768Y	CNGB3_uc010maj.2_Missense_Mutation_p.H625Y	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	768	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CTAACTGAGTGGGGTTCTTCCT	0.436			NA											8	81					0	0	0.004672	0	0
MMP16	4325	broad.mit.edu	37	8	89128926	89128926	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:89128926G>T	uc003yeb.3	-	6	1175	c.893C>A	c.(892-894)CCA>CAA	p.P298Q	MMP16_uc003yec.2_Missense_Mutation_p.P298Q	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	298	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TCTTGTAGGTGGAGGAATCTT	0.502			NA											11	95					2.27111e-07	3.68043e-07	0.001368	1	0
NECAB1	64168	broad.mit.edu	37	8	91963393	91963393	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:91963393T>C	uc011lgg.1	+	12	1185	c.991T>C	c.(991-993)TTG>CTG	p.L331L	NECAB1_uc003yer.2_Silent_p.L80L	NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	331					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			TGTGGATTTCTTGGAAACTCC	0.338			NA											5	36					0	0	0.001168	0	0
TMEM67	91147	broad.mit.edu	37	8	94798502	94798502	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:94798502C>T	uc011lgk.1	+	13	1411	c.1340C>T	c.(1339-1341)GCA>GTA	p.A447V	TMEM67_uc010mat.1_Missense_Mutation_p.A362V|TMEM67_uc010maw.2_Missense_Mutation_p.A153V|TMEM67_uc003yga.3_Missense_Mutation_p.A366V	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	447					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			TTAGTGGATGCAGTAAGTGGA	0.338			NA											4	97					0	0	0.000602	0	0
CDH17	1015	broad.mit.edu	37	8	95189829	95189829	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:95189829T>A	uc003ygh.2	-	4	396	c.271A>T	c.(271-273)ACT>TCT	p.T91S	CDH17_uc011lgo.1_Missense_Mutation_p.T91S|CDH17_uc011lgp.1_Missense_Mutation_p.T91S	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	91	Extracellular (Potential).|Cadherin 1.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			AGATTGTGAGTAGATCTTGTT	0.453			NA											7	111					0	0	0.001984	0	0
KIAA1429	25962	broad.mit.edu	37	8	95524282	95524282	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:95524282G>C	uc003ygo.1	-	12	2800	c.2787C>G	c.(2785-2787)GGC>GGG	p.G929G	KIAA1429_uc003ygp.2_Silent_p.G929G|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	929					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CAGTGGTAAGGCCAACTCCTT	0.388			NA											3	14					0	0	0.004672	0	0
C8orf37	157657	broad.mit.edu	37	8	96281405	96281405	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:96281405G>T	uc003yho.1	-	1	33	c.13C>A	c.(13-15)CTG>ATG	p.L5M		NM_177965	NP_808880	Q96NL8	CH037_HUMAN	hypothetical protein LOC157657	5											0	Breast(36;3.41e-05)					AGCTCGTCCAGGTCCTCCGCC	0.622			NA									OREG0018873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	184					2.17888e-05	3.14511e-05	0.006214	1	0
VPS13B	157680	broad.mit.edu	37	8	100148980	100148980	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:100148980G>C	uc003yiv.2	+	12	1762	c.1651G>C	c.(1651-1653)GGT>CGT	p.G551R	VPS13B_uc003yiw.2_Missense_Mutation_p.G551R|VPS13B_uc003yit.2_Missense_Mutation_p.G551R|VPS13B_uc003yiu.1_Missense_Mutation_p.G551R|VPS13B_uc003yix.1_Missense_Mutation_p.G22R	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	551					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TAGTGGCAAAGGTATTGGCTT	0.418	Colon(161;2205 2542 7338 31318)		NA											4	99					0	0	0.000248	0	0
VPS13B	157680	broad.mit.edu	37	8	100832257	100832257	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:100832257C>A	uc003yiv.2	+	49	9087	c.8976C>A	c.(8974-8976)ATC>ATA	p.I2992I	VPS13B_uc003yiw.2_Silent_p.I2967I	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2992					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCCTGCTTATCAATGAATCCA	0.423	Colon(161;2205 2542 7338 31318)		NA											9	154					3.09899e-07	4.96537e-07	0.004482	1	0
ATP6V1C1	528	broad.mit.edu	37	8	104066159	104066159	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:104066159A>T	uc003ykz.3	+	7	766	c.521A>T	c.(520-522)GAC>GTC	p.D174V	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.D99V|ATP6V1C1_uc003yla.2_Missense_Mutation_p.D174V|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.D99V	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	174					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			AAGAAGGATGACTTTGTTCTT	0.323			NA											8	87					0	0	0.006214	0	0
RIMS2	9699	broad.mit.edu	37	8	104987593	104987593	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:104987593G>A	uc003yls.2	+	14	2361	c.2120G>A	c.(2119-2121)GGT>GAT	p.G707D	RIMS2_uc003ylp.2_Missense_Mutation_p.G929D|RIMS2_uc003ylw.2_Missense_Mutation_p.G721D|RIMS2_uc003ylq.2_Missense_Mutation_p.G721D|RIMS2_uc003ylr.2_Missense_Mutation_p.G768D|RIMS2_uc003ylt.2_Missense_Mutation_p.G314D	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	991					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CGACATGATGGTCGAGATCTT	0.348			NA								HNSCC(12;0.0054)			4	27					0	0	0.000602	0	0
RIMS2	9699	broad.mit.edu	37	8	105263260	105263260	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:105263260G>T	uc003yls.2	+	27	3995	c.3754G>T	c.(3754-3756)GTA>TTA	p.V1252L	RIMS2_uc003ylp.2_Missense_Mutation_p.V1234L|RIMS2_uc003ylw.2_Missense_Mutation_p.V1241L|RIMS2_uc003ylq.2_Missense_Mutation_p.V1048L|RIMS2_uc003ylr.2_Missense_Mutation_p.V1073L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1296	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGCACCGTATGTAAAAGTGTA	0.398			NA								HNSCC(12;0.0054)			6	49					0.00198382	0.00238984	0.001984	1	0
RIMS2	9699	broad.mit.edu	37	8	105263899	105263899	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:105263899G>T	uc003yls.2	+	28	4196	c.3955G>T	c.(3955-3957)GAT>TAT	p.D1319Y	RIMS2_uc003ylp.2_Missense_Mutation_p.D1301Y|RIMS2_uc003ylq.2_Missense_Mutation_p.D1115Y|RIMS2_uc003ylr.2_Missense_Mutation_p.D1140Y	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1363					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GATACTTTTAGATGAACTAGA	0.448			NA								HNSCC(12;0.0054)			14	99					1.49906e-05	2.17766e-05	0.00245	1	0
LRP12	29967	broad.mit.edu	37	8	105503207	105503207	+	Silent	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:105503207T>C	uc003yma.2	-	7	2369	c.2274A>G	c.(2272-2274)AGA>AGG	p.R758R	LRP12_uc003ymb.2_Silent_p.R739R|LRP12_uc003ylz.2_Silent_p.R164R	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	758	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TATCAAGTTGTCTCAAAGGAC	0.423			NA											5	68					0	0	0.000602	0	0
OXR1	55074	broad.mit.edu	37	8	107691480	107691480	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:107691480G>A	uc011lht.1	+	3	365	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	OXR1_uc003ymf.2_Missense_Mutation_p.R88Q|OXR1_uc011lhu.1_Missense_Mutation_p.R81Q|OXR1_uc010mcg.2_Intron|OXR1_uc003ymg.1_Missense_Mutation_p.R21Q|OXR1_uc003ymi.1_5'UTR	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	89					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			GATGGAAGACGAATGTCTTTT	0.338			NA											7	43					0	0	0.004482	0	0
RSPO2	340419	broad.mit.edu	37	8	109094816	109094816	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:109094816A>T	uc003yms.2	-	2	709	c.51T>A	c.(49-51)GAT>GAA	p.D17E	RSPO2_uc003ymq.2_5'Flank|RSPO2_uc003ymr.2_Missense_Mutation_p.D17E	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	17					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			AGTGGCTGTAATCCATGCAGT	0.597			NA											8	29					0	0	0.004482	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477060	110477060	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:110477060G>T	uc003yne.2	+	49	8103	c.7999G>T	c.(7999-8001)GCC>TCC	p.A2667S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2667	Extracellular (Potential).|PbH1 3.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAATGGAGGTGCCCTTCAGTT	0.448			NA								HNSCC(38;0.096)			9	77					7.48243e-07	1.17892e-06	0.006214	1	0
CSMD3	114788	broad.mit.edu	37	8	113694713	113694713	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:113694713C>A	uc003ynu.2	-	16	2794	c.2635G>T	c.(2635-2637)GAT>TAT	p.D879Y	CSMD3_uc003yns.2_Missense_Mutation_p.D151Y|CSMD3_uc003ynt.2_Missense_Mutation_p.D839Y|CSMD3_uc011lhx.1_Missense_Mutation_p.D775Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	879	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTTTTCCATCCATAAGAATA	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	100					0.00198382	0.00238984	0.001984	1	0
TRPS1	7227	broad.mit.edu	37	8	116616676	116616676	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:116616676G>A	uc003ynz.2	-	3	1940	c.1481C>T	c.(1480-1482)ACA>ATA	p.T494I	TRPS1_uc011lhy.1_Missense_Mutation_p.T498I|TRPS1_uc003yny.2_Missense_Mutation_p.T507I|TRPS1_uc010mcy.2_Missense_Mutation_p.T494I	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	494					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTTGGTCATTGTCTCTCCTTC	0.458			NA							Langer-Giedion_syndrome				4	110					0	0	0.000248	0	0
RAD21	5885	broad.mit.edu	37	8	117868937	117868937	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:117868937C>G	uc003yod.2	-	7	1050	c.762G>C	c.(760-762)ATG>ATC	p.M254I		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	254					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					GCTCTGGCAACATCACCCCTG	0.423			NA											10	85					0	0	0.008291	0	0
COL14A1	7373	broad.mit.edu	37	8	121222052	121222052	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:121222052G>A	uc003yox.2	+	12	1644	c.1379G>A	c.(1378-1380)CGA>CAA	p.R460Q	COL14A1_uc003yoy.2_Missense_Mutation_p.R138Q|COL14A1_uc010mde.1_Missense_Mutation_p.R138Q	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	460	Fibronectin type-III 3.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AACAGCATGCGAGTCAAATGG	0.468			NA											5	90					0	0	0.001984	0	0
OC90	729330	broad.mit.edu	37	8	133053387	133053387	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:133053387G>T	uc003ytg.2	-	4	313	c.313C>A	c.(313-315)CGC>AGC	p.R105S	OC90_uc011lix.1_Missense_Mutation_p.R121S	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	121	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TAGCACCTGCGGTGCTGGAAG	0.552			NA											8	98					0.00307968	0.00367105	0.00308	1	0
PHF20L1	51105	broad.mit.edu	37	8	133807005	133807005	+	Silent	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:133807005G>C	uc003ytt.2	+	4	607	c.282G>C	c.(280-282)CTG>CTC	p.L94L	PHF20L1_uc003ytr.2_Silent_p.L94L|PHF20L1_uc010mdv.2_Silent_p.L94L|PHF20L1_uc003yts.2_Silent_p.L94L|PHF20L1_uc011lja.1_Silent_p.L94L|PHF20L1_uc003ytu.1_RNA|PHF20L1_uc003ytq.2_Silent_p.L94L	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	94	Tudor 2.						nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AAGAAGTTCTGGCTCGTTGGA	0.313			NA											6	33					0	0	0.001984	0	0
PHF20L1	51105	broad.mit.edu	37	8	133829707	133829707	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:133829707G>T	uc003ytt.2	+	12	1821	c.1496G>T	c.(1495-1497)AGG>ATG	p.R499M	PHF20L1_uc003yts.2_Missense_Mutation_p.R499M|PHF20L1_uc011lja.1_Missense_Mutation_p.R473M|PHF20L1_uc003ytu.1_RNA	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	499							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GAATGTCCCAGGGCAGAAAAA	0.463			NA											8	32					1.12685e-05	1.66247e-05	0.004482	1	0
TG	7038	broad.mit.edu	37	8	133931682	133931682	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:133931682C>A	uc003ytw.2	+	21	4481	c.4440C>A	c.(4438-4440)TTC>TTA	p.F1480L	TG_uc010mdw.2_Missense_Mutation_p.F239L|TG_uc011ljb.1_5'UTR|TG_uc003ytx.1_RNA	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1480	Type II.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTGTTGGATTCTACCAAGAAC	0.453			NA											8	51					0.00307968	0.00367105	0.00308	1	0
COL22A1	169044	broad.mit.edu	37	8	139668139	139668139	+	Splice_Site	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:139668139C>A	uc003yvd.2	-	45	3780	c.3333_splice	c.e45+1	p.K1111_splice	COL22A1_uc011ljo.1_Splice_Site_p.K391_splice	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TATGCTTTTACCTTAGCCAAG	0.358			NA								HNSCC(7;0.00092)			11	175					2.27111e-07	3.68043e-07	0.001368	1	0
DMRT1	1761	broad.mit.edu	37	9	847037	847037	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:847037G>C	uc003zgv.2	+	2	581	c.432G>C	c.(430-432)GAG>GAC	p.E144D	DMRT1_uc003zgu.1_Missense_Mutation_p.E144D	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	144					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		GTGCGGCCGAGCTGCTTGTCA	0.612			NA											5	57					0	0	0.000602	0	0
DMRT3	58524	broad.mit.edu	37	9	990523	990523	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:990523A>G	uc003zgw.1	+	2	975	c.937A>G	c.(937-939)ATC>GTC	p.I313V		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	313					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		CAATGGGCACATCTTTGAACA	0.562			NA											4	61					0	0	0.000248	0	0
RFX3	5991	broad.mit.edu	37	9	3257050	3257050	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:3257050T>A	uc003zhr.2	-	15	2067	c.1755A>T	c.(1753-1755)GAA>GAT	p.E585D	RFX3_uc010mhd.2_Missense_Mutation_p.E585D|RFX3_uc003zhs.1_Missense_Mutation_p.E585D	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	585					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		TGGGTCTTCCTTCATAGGGTT	0.458			NA											18	98					0	0	0.007413	0	0
PTPRD	5789	broad.mit.edu	37	9	8528611	8528611	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:8528611C>A	uc003zkk.2	-	14	1232	c.521G>T	c.(520-522)CGT>CTT	p.R174L	PTPRD_uc003zkp.2_Missense_Mutation_p.R174L|PTPRD_uc003zkq.2_Missense_Mutation_p.R174L|PTPRD_uc003zkr.2_Missense_Mutation_p.R174L|PTPRD_uc003zks.2_Missense_Mutation_p.R174L|PTPRD_uc003zkl.2_Missense_Mutation_p.R174L|PTPRD_uc003zkm.2_Missense_Mutation_p.R174L|PTPRD_uc003zkn.2_Missense_Mutation_p.R174L|PTPRD_uc003zko.2_Missense_Mutation_p.R174L|PTPRD_uc003zkt.1_Missense_Mutation_p.R174L	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	174	Extracellular (Potential).|Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTGCTTAATACGACCATTGTT	0.353			NA								TSP Lung(15;0.13)			9	102					0.000673444	0.000838851	0.008291	1	0
FAM154A	158297	broad.mit.edu	37	9	18928669	18928669	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:18928669C>A	uc003zni.1	-	4	1084	c.806G>T	c.(805-807)TGT>TTT	p.C269F	FAM154A_uc010mip.1_Missense_Mutation_p.C77F	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	269										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		AGTGGTGTTACAGAAAGGCAT	0.542			NA											7	42					2.0095e-06	3.08069e-06	0.001984	1	0
MLLT3	4300	broad.mit.edu	37	9	20414102	20414102	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:20414102C>T	uc003zoe.2	-	5	1001	c.742G>A	c.(742-744)GTT>ATT	p.V248I	MLLT3_uc011lne.1_Missense_Mutation_p.V216I|MLLT3_uc011lnf.1_Missense_Mutation_p.V245I|MLLT3_uc003zof.2_Missense_Mutation_p.V49I	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		ATCTTAGGAACTATTTTCTCT	0.398			NA	T	MLL	ALL								23	215					0	0	0.002299	0	0
IFNA6	3443	broad.mit.edu	37	9	21350457	21350457	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:21350457T>C	uc011lni.1	-	1	430	c.430A>G	c.(430-432)AGA>GGA	p.R144G		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	144					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AAGTATTTTCTCACAGCCAGG	0.498			NA											10	172					0	0	0.008291	0	0
TAF1L	138474	broad.mit.edu	37	9	32633177	32633178	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:32633177_32633178CC>AA	uc003zrg.1	-	1	2490_2491	c.2400_2401GG>TT	c.(2398-2403)GTGGTT>GTTTTT	p.V801F	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	801					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGCTGGCCAACCACAAAAATAT	0.421			NA											7	74					0	0	0.004672	0	0
TAF1L	138474	broad.mit.edu	37	9	32633194	32633194	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:32633194A>G	uc003zrg.1	-	1	2474	c.2384T>C	c.(2383-2385)TTA>TCA	p.L795S	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	795					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AATATCCACTAATTCCCGAAT	0.428			NA											6	73					0	0	0.00632	0	0
FANCG	2189	broad.mit.edu	37	9	35074929	35074929	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:35074929C>A	uc003zwb.1	-	12	2123	c.1631G>T	c.(1630-1632)TGC>TTC	p.C544F	VCP_uc003zvy.2_5'Flank|VCP_uc003zvz.2_5'Flank|VCP_uc010mkh.1_5'Flank|VCP_uc010mki.1_5'Flank|FANCG_uc003zwa.1_Missense_Mutation_p.C286F|FANCG_uc010mkj.1_Missense_Mutation_p.C286F	NM_004629	NP_004620	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	544	TPR 4.				cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|large_intestine(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CATACCTGGGCACATCTGCAC	0.532			NA	Mis|N|F|S			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				16	54					1.15088e-07	1.89204e-07	0.004007	1	0
PAX5	5079	broad.mit.edu	37	9	36966657	36966657	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:36966657C>A	uc003zzo.1	-	6	1117	c.669G>T	c.(667-669)CAG>CAT	p.Q223H	PAX5_uc011lpt.1_5'UTR|PAX5_uc011lpu.1_Intron|PAX5_uc011lpv.1_Intron|PAX5_uc011lpw.1_Missense_Mutation_p.Q223H|PAX5_uc011lpx.1_Missense_Mutation_p.Q157H|PAX5_uc011lpy.1_Missense_Mutation_p.Q115H|PAX5_uc010mls.1_Missense_Mutation_p.Q223H|PAX5_uc011lpz.1_Missense_Mutation_p.Q180H|PAX5_uc011lqa.1_Missense_Mutation_p.Q115H|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.Q223H|PAX5_uc010mlp.1_Missense_Mutation_p.Q223H|PAX5_uc011lqc.1_Missense_Mutation_p.Q180H|PAX5_uc010mlr.1_Missense_Mutation_p.Q223H	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	223					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(22)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CTCCCCGCATCTGCTTCCGGA	0.587			NA	T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								3	38					0.00024832	0.000325365	0.000248	1	0
ANKRD20A3	441425	broad.mit.edu	37	9	42368337	42368337	+	Translation_Start_Site	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:42368337G>T	uc004acd.2	+	1	35	c.-77G>T	c.(-79--75)GAGGG>GATGG		ANKRD20A3_uc010mmv.2_Translation_Start_Site	NM_001012419	NP_001012419	Q5VUR7	A20A3_HUMAN	ankyrin repeat domain 20 family, member A3												0						gggtcggggagggggttggTG	0.294			NA											10	9					0.000442599	0.000568128	0.006214	1	0
FAM75A6	389730	broad.mit.edu	37	9	43627193	43627193	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:43627193A>T	uc011lrb.1	-	4	1523	c.1494T>A	c.(1492-1494)CAT>CAA	p.H498Q		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	498						integral to membrane					0						AAGACTGAAGATGGGCCTGAG	0.537			NA											18	238					0	0	0.008871	0	0
RORB	6096	broad.mit.edu	37	9	77275592	77275592	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:77275592G>T	uc004aji.2	+	5	779	c.730G>T	c.(730-732)GAG>TAG	p.E244*	RORB_uc004ajh.2_Nonsense_Mutation_p.E233*	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	244	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CACCATGGAAGAGCTGCACCA	0.398			NA											7	84					0.00198382	0.00238984	0.001984	1	0
TRPM6	140803	broad.mit.edu	37	9	77397635	77397635	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:77397635G>T	uc004ajl.1	-	22	3292	c.3054C>A	c.(3052-3054)TAC>TAA	p.Y1018*	TRPM6_uc004ajk.1_Nonsense_Mutation_p.Y1013*|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Nonsense_Mutation_p.Y304*	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1018					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						ATATCATCCAGTATGGCTCAA	0.443			NA											8	52					1.12685e-05	1.66247e-05	0.004482	1	0
FLJ46321	389763	broad.mit.edu	37	9	84609145	84609145	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:84609145G>A	uc004amn.2	+	4	3807	c.3760G>A	c.(3760-3762)GTG>ATG	p.V1254M		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1254						integral to membrane					0						AACTTCCCAGGTGGTGCATGT	0.502			NA											34	96					0	0	0.002445	0	0
SECISBP2	79048	broad.mit.edu	37	9	91943769	91943769	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:91943769G>C	uc004aqj.1	+	5	849	c.769G>C	c.(769-771)GAA>CAA	p.E257Q	SECISBP2_uc010mqn.1_Missense_Mutation_p.E257Q|SECISBP2_uc004aqi.1_Missense_Mutation_p.E184Q|SECISBP2_uc011ltk.1_Missense_Mutation_p.E256Q|SECISBP2_uc004aqk.1_Missense_Mutation_p.E184Q|SECISBP2_uc010mqo.1_5'UTR|SECISBP2_uc011ltl.1_Missense_Mutation_p.E189Q	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	257					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						TCTTCTAAGAGAAGTAGTAAA	0.408			NA											4	31					0	0	0.000602	0	0
SPTLC1	10558	broad.mit.edu	37	9	94821469	94821469	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:94821469C>T	uc004arl.1	-	7	720	c.682G>A	c.(682-684)GAT>AAT	p.D228N	SPTLC1_uc011ltv.1_Missense_Mutation_p.D228N|SPTLC1_uc004arm.1_Missense_Mutation_p.D228N	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	228	Cytoplasmic (Potential).					integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACCTTTTGATCTTCGATCTCT	0.328			NA											4	19					0	0	0.000248	0	0
CENPP	401541	broad.mit.edu	37	9	95099903	95099903	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:95099903G>T	uc004arz.2	+	3	910	c.370G>T	c.(370-372)GAA>TAA	p.E124*	CENPP_uc010mqx.2_Nonsense_Mutation_p.E12*|CENPP_uc004ary.1_Nonsense_Mutation_p.E124*	NM_001012267	NP_001012267	Q6IPU0	CENPP_HUMAN	centromere protein P	124					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2						TCAGATTCTGGAAATTCAGGT	0.363			NA											17	65					0.00074312	0.000924627	0.006122	1	0
ZNF169	169841	broad.mit.edu	37	9	97062215	97062215	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:97062215A>T	uc004aum.1	+	5	480	c.375A>T	c.(373-375)GCA>GCT	p.A125A		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	125						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				GCTCATCTGCAGGAGGTGACT	0.512			NA											4	31					0	0	0.000602	0	0
ZNF189	7743	broad.mit.edu	37	9	104170866	104170866	+	Silent	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:104170866A>G	uc004bbh.1	+	3	1092	c.816A>G	c.(814-816)AAA>AAG	p.K272K	ZNF189_uc004bbg.1_Silent_p.K230K|ZNF189_uc004bbi.1_Silent_p.K258K|ZNF189_uc011lvk.1_Silent_p.K257K	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	272	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				TCAGTTGGAAATCACACCTTA	0.413			NA											19	111					0	0	0.001523	0	0
TLR4	7099	broad.mit.edu	37	9	120474985	120474985	+	Silent	SNP	A	A	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:120474985A>C	uc004bjz.2	+	3	870	c.579A>C	c.(577-579)ACA>ACC	p.T193T	TLR4_uc004bka.2_Silent_p.T153T|TLR4_uc004bkb.2_5'UTR	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	193	Extracellular (Potential).|LRR 6.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTTATTGCACAGACTTGCGGG	0.378			NA											9	51					0	0	0.008291	0	0
TLR4	7099	broad.mit.edu	37	9	120475619	120475619	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:120475619G>A	uc004bjz.2	+	3	1504	c.1213G>A	c.(1213-1215)GAT>AAT	p.D405N	TLR4_uc004bka.2_Missense_Mutation_p.D365N|TLR4_uc004bkb.2_Missense_Mutation_p.D205N	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	405	LRR 12.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AAAGTATTTAGATCTGAGCTT	0.383			NA											8	36					0	0	0.004482	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123253727	123253727	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:123253727C>G	uc004bkf.2	-	13	1521	c.1340G>C	c.(1339-1341)CGC>CCC	p.R447P	CDK5RAP2_uc004bkg.2_Missense_Mutation_p.R447P|CDK5RAP2_uc011lxw.1_5'UTR|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_5'UTR|CDK5RAP2_uc011lya.1_5'UTR|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.R447P|CDK5RAP2_uc004bki.2_Missense_Mutation_p.R246P	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	447					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CACTTCATTGCGTAATTTTTC	0.308			NA											3	35					0	0	0.000248	0	0
OR1N2	138882	broad.mit.edu	37	9	125315694	125315694	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:125315694C>A	uc011lyx.1	+	1	246	c.246C>A	c.(244-246)AAC>AAA	p.N82K		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	82	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						TTCTGGCCAACCTGTCATTAA	0.502			NA											7	87					5.68852e-11	1.04061e-10	0.004482	1	0
SPTAN1	6709	broad.mit.edu	37	9	131369914	131369914	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:131369914G>T	uc004bvl.3	+	32	4191	c.4078G>T	c.(4078-4080)GGG>TGG	p.G1360W	SPTAN1_uc004bvm.3_Missense_Mutation_p.G1360W|SPTAN1_uc004bvn.3_Missense_Mutation_p.G1340W	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1360	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGGAATACGGGGGTTGGTGTC	0.522	NSCLC(120;833 1744 2558 35612 37579)		NA											11	92					6.40141e-05	8.8683e-05	0.000978	1	0
DOLPP1	57171	broad.mit.edu	37	9	131847036	131847036	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:131847036G>T	uc004bxc.2	+	2	194	c.166G>T	c.(166-168)GAG>TAG	p.E56*	DOLPP1_uc004bxd.2_Nonsense_Mutation_p.E56*|DOLPP1_uc004bxe.2_RNA|DOLPP1_uc004bxf.2_5'Flank	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	56					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						ATTTAAGCGGGAGCTGCACAC	0.607			NA											9	187					0.000442599	0.000568128	0.006214	1	0
PPAPDC3	84814	broad.mit.edu	37	9	134165627	134165627	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:134165627C>A	uc004cal.2	+	1	547	c.243C>A	c.(241-243)GCC>GCA	p.A81A		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain	81	interaction with MTOR (By similarity).|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(1)	1	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		AGGGCATCGCCTTCAACTCCC	0.662			NA											10	75					6.42651e-13	1.21675e-12	0.000978	1	0
C9orf171	389799	broad.mit.edu	37	9	135357749	135357749	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:135357749C>A	uc004cbn.2	+	2	296	c.248C>A	c.(247-249)GCG>GAG	p.A83E	C9orf171_uc004cbo.2_Intron	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	83										ovary(4)|large_intestine(1)	5						GACTCCTCAGCGGTGCAGAAA	0.493			NA											8	46					0.000274275	0.000355681	0.004482	1	0
BARHL1	56751	broad.mit.edu	37	9	135464640	135464640	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:135464640G>A	uc004cbp.1	+	3	907	c.715G>A	c.(715-717)GTC>ATC	p.V239I		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	239						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		ACAGACGGCCGTCGGGTTGGA	0.612			NA											18	97					0	0	0.001523	0	0
SURF6	6838	broad.mit.edu	37	9	136198959	136198959	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr9:136198959C>A	uc004cdb.3	-	5	910	c.832G>T	c.(832-834)GAG>TAG	p.E278*		NM_006753	NP_006744	O75683	SURF6_HUMAN	surfeit 6	278						granular component	DNA binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		TTCACGCCCTCCGCCTTGTAG	0.682			NA											16	66					3.41278e-10	6.12468e-10	0.00499	1	0
ASMT	438	broad.mit.edu	37	X	1748721	1748721	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:1748721G>T	uc004cqd.2	+	6	596	c.451G>T	c.(451-453)GGC>TGC	p.G151C	ASMT_uc010ncy.2_Missense_Mutation_p.G151C|ASMT_uc004cqe.2_Missense_Mutation_p.G151C	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	151					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CAGGTCCGAGGGCGAGCGGCT	0.572			NA											11	77					2.27111e-07	3.68043e-07	0.001368	1	0
MXRA5	25878	broad.mit.edu	37	X	3239784	3239784	+	Silent	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:3239784T>A	uc004crg.3	-	5	4099	c.3942A>T	c.(3940-3942)CCA>CCT	p.P1314P		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1314						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TATATGTGACTGGAAGTGTCT	0.363			NA											11	41					0	0	0.001855	0	0
AMELX	265	broad.mit.edu	37	X	11316810	11316810	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:11316810C>T	uc004cut.2	+	5	355	c.287C>T	c.(286-288)CCC>CTC	p.P96L	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.P110L|AMELX_uc004cuu.2_Missense_Mutation_p.P80L	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	96					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						CCCGTGATCCCCCAGCAACCA	0.632			NA											3	53					0	0	0.000248	0	0
TLR7	51284	broad.mit.edu	37	X	12905856	12905856	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:12905856A>T	uc004cvc.2	+	3	2368	c.2229A>T	c.(2227-2229)CTA>CTT	p.L743L		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	743	LRR 25.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	AGTATTTTCTACAAGATGCCT	0.403			NA											4	33					0	0	0.000248	0	0
TLR8	51311	broad.mit.edu	37	X	12940186	12940186	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:12940186G>A	uc004cve.2	+	2	3095	c.3027G>A	c.(3025-3027)AAG>AAA	p.K1009K	TLR8_uc004cvd.2_Silent_p.K1027K	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	1009	Cytoplasmic (Potential).|TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						ACAACCCGAAGGCAGAAGGCT	0.443			NA											9	44					0	0	0.004482	0	0
EGFL6	25975	broad.mit.edu	37	X	13641992	13641992	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:13641992G>T	uc004cvi.2	+	10	1473	c.1233G>T	c.(1231-1233)TGG>TGT	p.W411C	EGFL6_uc004cvj.2_Missense_Mutation_p.W412C	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	411	MAM.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						TCTGTGACTGGAAACAGGATA	0.368			NA											4	28					0.000602214	0.000754262	0.000602	1	0
EIF1AX	1964	broad.mit.edu	37	X	20156717	20156717	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:20156717T>A	uc004czt.2	-	2	248	c.40A>T	c.(40-42)AGG>TGG	p.R14W	SCARNA9L_uc010nfp.2_5'Flank	NM_001412	NP_001403	P47813	IF1AX_HUMAN	X-linked eukaryotic translation initiation	14						cytosol	translation initiation factor activity			ovary(1)	1						TTCTTACCCCTGCGTCTGTTT	0.303			NA											8	34					0	0	0.004482	0	0
DMD	1756	broad.mit.edu	37	X	32862918	32862918	+	Silent	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:32862918C>A	uc004dda.1	-	4	490	c.246G>T	c.(244-246)CGG>CGT	p.R82R	DMD_uc004dcz.2_5'UTR|DMD_uc004dcy.1_Silent_p.R78R|DMD_uc004ddb.1_Silent_p.R74R|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Silent_p.R74R|DMD_uc010ngq.1_RNA|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	82	CH 1.|Actin-binding.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTGCAAAACCCGCAGTGCCT	0.463			NA											4	15					0.000602214	0.000754262	0.000602	1	0
FAM47C	442444	broad.mit.edu	37	X	37027104	37027104	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:37027104G>T	uc004ddl.1	+	1	635	c.621G>T	c.(619-621)GTG>GTT	p.V207V		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	207										ovary(3)	3						AGACTCCGGTGTCCAGTCTCC	0.647			NA											3	23					0.004672	0.00544907	0.004672	1	0
PRRG1	5638	broad.mit.edu	37	X	37312649	37312649	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:37312649G>T	uc004ddn.2	+	5	685	c.432G>T	c.(430-432)TTG>TTT	p.L144F	PRRG1_uc004ddo.2_Missense_Mutation_p.L144F	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	144	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2						GCAGTGGATTGTCTCCAGGCT	0.532			NA											12	23					4.3838e-07	6.98457e-07	0.001855	1	0
NYX	60506	broad.mit.edu	37	X	41333679	41333679	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:41333679G>T	uc004dfh.2	+	2	1403	c.973G>T	c.(973-975)GGC>TGC	p.G325C	NYX_uc011mku.1_Missense_Mutation_p.G320C	NM_022567	NP_072089	Q9GZU5	NYX_HUMAN	nyctalopin precursor	325					response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				lung(2)	2						CTTCCAGCCCGGCTTCTTCCT	0.677			NA											3	18					1.23904e-05	1.80687e-05	0.000602	1	0
KIAA2022	340533	broad.mit.edu	37	X	73961230	73961230	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:73961230A>T	uc004eby.2	-	3	3779	c.3162T>A	c.(3160-3162)GAT>GAA	p.D1054E		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1054					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						AGTTGGATATATCCAGGAGGT	0.498			NA											4	41					0	0	0.000248	0	0
PCDH11X	27328	broad.mit.edu	37	X	91134011	91134011	+	Silent	SNP	A	A	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:91134011A>T	uc004efk.1	+	2	3617	c.2772A>T	c.(2770-2772)ACA>ACT	p.T924T	PCDH11X_uc004efl.1_Silent_p.T924T|PCDH11X_uc004efo.1_Silent_p.T924T|PCDH11X_uc010nmv.1_Silent_p.T924T|PCDH11X_uc004efm.1_Silent_p.T924T|PCDH11X_uc004efn.1_Silent_p.T924T|PCDH11X_uc004efh.1_Silent_p.T924T|PCDH11X_uc004efj.1_Silent_p.T924T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	924	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GGGTAACTACACCTACTACTT	0.463	NSCLC(38;925 1092 2571 38200 45895)		NA											20	47					0	0	0.008871	0	0
ZMAT1	84460	broad.mit.edu	37	X	101138771	101138771	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:101138771C>A	uc004eim.2	-	2	4613	c.1115G>T	c.(1114-1116)CGA>CTA	p.R372L	ZMAT1_uc011mrl.1_Missense_Mutation_p.R543L|ZMAT1_uc004ein.2_Missense_Mutation_p.R372L|ZMAT1_uc011mrm.1_Missense_Mutation_p.R372L	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	372						nucleus	zinc ion binding			ovary(1)	1						TTCTAGGTGTCGTTTTCTCTT	0.388			NA											7	41					1.06961e-07	1.76868e-07	0.00308	1	0
TCEAL8	90843	broad.mit.edu	37	X	102508698	102508698	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:102508698C>G	uc004ejx.2	-	3	437	c.210G>C	c.(208-210)TTG>TTC	p.L70F	TCEAL8_uc004ejy.2_Missense_Mutation_p.L70F	NM_153333	NP_699164	Q8IYN2	TCAL8_HUMAN	transcription elongation factor A (SII)-like 8	70					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTTCAGGGTCCAAATGCCTAA	0.473			NA											14	56					0	0	0.001855	0	0
PLP1	5354	broad.mit.edu	37	X	103041621	103041621	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:103041621A>G	uc010nov.2	+	4	699	c.419A>G	c.(418-420)CAT>CGT	p.H140R	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Missense_Mutation_p.H140R|PLP1_uc004elj.2_Intron|PLP1_uc011msf.1_Missense_Mutation_p.H85R|PLP1_uc010now.1_Missense_Mutation_p.H144R|PLP1_uc010nox.2_Missense_Mutation_p.H94R	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	140	Cytoplasmic (Probable).		H -> Y (in SPG2).|Missing (in HLD1).	H -> T (in Ref. 7; AAA60117).	cell death|synaptic transmission	integral to membrane				ovary(1)	1						CGGGTGTGTCATTGTTTGGGA	0.557			NA											8	59					0	0	0.004482	0	0
VSIG1	340547	broad.mit.edu	37	X	107315961	107315961	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:107315961C>A	uc004eno.2	+	4	628	c.467C>A	c.(466-468)ACT>AAT	p.T156N	VSIG1_uc011msk.1_Missense_Mutation_p.T192N	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	156	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ACTGGCCACACTATTTCCCTT	0.443			NA											9	58					0.000673444	0.000838851	0.008291	1	0
GUCY2F	2986	broad.mit.edu	37	X	108631743	108631743	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:108631743G>T	uc004eod.3	-	15	3207	c.2931C>A	c.(2929-2931)GTC>GTA	p.V977V	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	977	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TTCGAATTCGGACCGGCACTT	0.448			NA											16	62					4.14922e-12	7.76526e-12	0.004007	1	0
CAPN6	827	broad.mit.edu	37	X	110494471	110494471	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:110494471G>C	uc004epc.1	-	7	1105	c.937C>G	c.(937-939)CTG>GTG	p.L313V	CAPN6_uc011msu.1_Missense_Mutation_p.L58V	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	313	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						ACAAGCCCCAGGTTCTTGCGA	0.393			NA											4	26					0	0	0.000602	0	0
TRPC5	7224	broad.mit.edu	37	X	111155830	111155830	+	Silent	SNP	G	G	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:111155830G>A	uc004epl.1	-	3	1508	c.589C>T	c.(589-591)CTG>TTG	p.L197L	TRPC5_uc004epm.1_Silent_p.L197L	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	197	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						TAGATGTTCAGTCGGGAGCGA	0.567			NA											18	50					0	0	0.00499	0	0
HTR2C	3358	broad.mit.edu	37	X	114141823	114141823	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:114141823G>T	uc004epu.1	+	6	1950	c.1222G>T	c.(1222-1224)GGG>TGG	p.G408W	HTR2C_uc010nqc.1_Missense_Mutation_p.G408W|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	408	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	TGCTTTGTCTGGGAGGGAGCT	0.453			NA											9	41					1.12685e-05	1.66247e-05	0.004482	1	0
BCORL1	63035	broad.mit.edu	37	X	129147031	129147031	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:129147031C>T	uc004evb.1	+	4	397	c.283C>T	c.(283-285)CCC>TCC	p.P95S	BCORL1_uc010nrd.1_5'UTR	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	95					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GCCTGACGATCCCCAGCCAAA	0.597			NA											4	27					0	0	0.000248	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130219600	130219600	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:130219600C>A	uc004evz.2	+	8	1339	c.994C>A	c.(994-996)CTG>ATG	p.L332M	ARHGAP36_uc004ewa.2_Missense_Mutation_p.L320M|ARHGAP36_uc004ewb.2_Missense_Mutation_p.L301M|ARHGAP36_uc004ewc.2_Missense_Mutation_p.L196M	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	332	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CCTGCAGTTGCTGGTCTACCT	0.527			NA											17	123					1.5739e-10	2.85159e-10	0.004007	1	0
SLC9A6	10479	broad.mit.edu	37	X	135098852	135098852	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:135098852A>G	uc004ezj.2	+	10	1265	c.1189A>G	c.(1189-1191)ATG>GTG	p.M397V	SLC9A6_uc004ezk.2_Missense_Mutation_p.M429V	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	397	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					CTTCTCCTACATGGGGCTGAC	0.333			NA											4	28					0	0	0.001168	0	0
GPR112	139378	broad.mit.edu	37	X	135431491	135431491	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:135431491C>T	uc004ezu.1	+	6	5917	c.5626C>T	c.(5626-5628)CAA>TAA	p.Q1876*	GPR112_uc010nsb.1_Nonsense_Mutation_p.Q1671*|GPR112_uc010nsc.1_Nonsense_Mutation_p.Q1643*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1876	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TAGTAATACCCAACCTCTGCT	0.433			NA											9	40					0	0	0.004482	0	0
MAGEC3	139081	broad.mit.edu	37	X	140983191	140983192	+	Missense_Mutation	DNP	AA	AA	TT			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	AA	AA	-	-	AA	AA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:140983191_140983192AA>TT	uc011mwp.1	+	5	1046_1047	c.1046_1047AA>TT	c.(1045-1047)CAA>CTT	p.Q349L	MAGEC3_uc004fbs.2_5'UTR|MAGEC3_uc010nsj.2_5'Flank	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	349	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GCCAATCCTCAAGGTAAGGGCC	0.579			NA											9	36					0	0	0.004672	0	0
PDZD4	57595	broad.mit.edu	37	X	153070179	153070179	+	Silent	SNP	G	G	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:153070179G>T	uc004fiz.1	-	8	1189	c.939C>A	c.(937-939)CGC>CGA	p.R313R	PDZD4_uc004fiy.1_Silent_p.R238R|PDZD4_uc004fix.2_Silent_p.R217R|PDZD4_uc004fja.1_Silent_p.R319R|PDZD4_uc011mze.1_Silent_p.R204R	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	313						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGCCAAACTTGCGCAGGCTTC	0.682			NA											5	13					1.23904e-05	1.80687e-05	0.000602	1	0
HIVEP3	59269	broad.mit.edu	37	1	42047882	42047882	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:42047882delC	uc001cgz.3	-	4	3800	c.2587delG	c.(2587-2589)GAGfs	p.E863fs	HIVEP3_uc001cha.3_Frame_Shift_Del_p.E863fs|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	863	Acidic 2.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Glu/Pro-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CGGTCAGGCTCCTCAGTTACT	0.617			NA											7	138	---	---	---	---	NA	NA	NA	NA	NA
CRTC2	200186	broad.mit.edu	37	1	153924914	153924915	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:153924914_153924915delTG	uc010ped.1	-	9	780_781	c.710_711delCA	c.(709-711)TCAfs	p.S237fs	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_5'UTR	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	237	Poly-Ser.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGGAAGAGGATGAGGATAGCTG	0.54			NA											19	92	---	---	---	---	NA	NA	NA	NA	NA
RALGPS2	55103	broad.mit.edu	37	1	178858785	178858785	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:178858785delG	uc001glz.2	+	14	1539	c.1201delG	c.(1201-1203)GATfs	p.D401fs	RALGPS2_uc010pnb.1_Frame_Shift_Del_p.D401fs	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	401					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						AGGTAGCAGCGATGGTTCTGA	0.318			NA											14	142	---	---	---	---	NA	NA	NA	NA	NA
EPRS	2058	broad.mit.edu	37	1	220195814	220195829	+	Frame_Shift_Del	DEL	GCTCCCTTTTTTCATT	GCTCCCTTTTTTCATT	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GCTCCCTTTTTTCATT	GCTCCCTTTTTTCATT	-	-	GCTCCCTTTTTTCATT	GCTCCCTTTTTTCATT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:220195814_220195829delGCTCCCTTTTTTCATT	uc001hly.1	-	9	1245_1260	c.975_990delAATGAAAAAAGGGAGC	c.(973-990)GAAATGAAAAAAGGGAGCfs	p.E325fs	EPRS_uc010puf.1_Frame_Shift_Del_p.E76fs|EPRS_uc001hlz.1_Frame_Shift_Del_p.E325fs|EPRS_uc009xdt.1_Frame_Shift_Del_p.E126fs	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	325_330	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	GACCAAACTGGCTCCCTTTTTTCATTTCTTCCCACA	0.352			NA											8	147	---	---	---	---	NA	NA	NA	NA	NA
ABCB10	23456	broad.mit.edu	37	1	229657378	229657378	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:229657378delC	uc001htp.3	-	11	1954	c.1911delG	c.(1909-1911)GGGfs	p.G637fs		NM_012089	NP_036221	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B, member 10	637	Mitochondrial intermembrane (Potential).|ABC transporter.|Mitochondrial matrix (Potential).					integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(2)	2	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				GCTGTTTCTGCCCACCTGACA	0.378			NA											13	45	---	---	---	---	NA	NA	NA	NA	NA
RYR2	6262	broad.mit.edu	37	1	237947550	237947550	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:237947550delG	uc001hyl.1	+	90	12658	c.12538delG	c.(12538-12540)GGCfs	p.G4180fs	RYR2_uc010pya.1_Frame_Shift_Del_p.G595fs	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4180					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTCAACGAAGGCGGAGAGAA	0.502			NA											11	69	---	---	---	---	NA	NA	NA	NA	NA
ZP4	57829	broad.mit.edu	37	1	238050766	238050766	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:238050766delG	uc001hym.2	-	5	649	c.649delC	c.(649-651)CTTfs	p.L217fs	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	217	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCATTCCTAAGGGCCAAGCGC	0.512	NSCLC(166;160 2029 11600 18754 19936)		NA											10	58	---	---	---	---	NA	NA	NA	NA	NA
OR2T8	343172	broad.mit.edu	37	1	248085108	248085109	+	Frame_Shift_Ins	INS	-	-	A	rs4625315	by1000genomes	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr1:248085108_248085109insA	uc010pzc.1	+	1	789_790	c.789_790insA	c.(787-792)CACAGGfs	p.H263fs		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	263_264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCAAATCCCACAGGTCCACTAA	0.49			NA											12	62	---	---	---	---	NA	NA	NA	NA	NA
CCDC147	159686	broad.mit.edu	37	10	106160471	106160471	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr10:106160471delC	uc001kyh.2	+	13	1983	c.1849delC	c.(1849-1851)CTTfs	p.L617fs		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	617										ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GGGGTCTCAGCTTGTTCGGCG	0.502			NA											11	90	---	---	---	---	NA	NA	NA	NA	NA
C11orf41	25758	broad.mit.edu	37	11	33564707	33564708	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:33564707_33564708insA	uc001mup.3	+	1	831_832	c.707_708insA	c.(706-708)GGGfs	p.G236fs	C11orf41_uc001mun.1_Frame_Shift_Ins_p.G236fs	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	236						integral to membrane				ovary(2)	2						GGCAGTGATGGGTCCCCTCCTG	0.515			NA									OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	63	---	---	---	---	NA	NA	NA	NA	NA
OR5A2	219981	broad.mit.edu	37	11	59189613	59189613	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr11:59189613delC	uc010rkt.1	-	1	814	c.814delG	c.(814-816)GACfs	p.D272fs		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCACCTTGTCCCTGTTTAGG	0.473			NA											8	55	---	---	---	---	NA	NA	NA	NA	NA
CD163	9332	broad.mit.edu	37	12	7639141	7639141	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr12:7639141delC	uc001qsz.3	-	10	2540	c.2412delG	c.(2410-2412)GGGfs	p.G804fs	CD163_uc001qta.3_Frame_Shift_Del_p.G804fs|CD163_uc009zfw.2_Frame_Shift_Del_p.G837fs	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	804	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						AATTTTGCTGCCCCCAGCCGT	0.478			NA											8	115	---	---	---	---	NA	NA	NA	NA	NA
ORAI3	93129	broad.mit.edu	37	16	30964748	30964748	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr16:30964748delG	uc002eac.2	+	2	677	c.471delG	c.(469-471)CTGfs	p.L157fs		NM_152288	NP_689501	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator	157	Helical; (Potential).					integral to membrane	protein binding				0						CCACTGCCCTGGGCACCTTTC	0.587			NA									OREG0023742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	170	---	---	---	---	NA	NA	NA	NA	NA
FBXW10	10517	broad.mit.edu	37	17	18682089	18682090	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr17:18682089_18682090delGA	uc002guk.2	+	14	2869_2870	c.2637_2638delGA	c.(2635-2640)GTGAAAfs	p.V879fs	FBXW10_uc002guj.2_Frame_Shift_Del_p.V878fs|FBXW10_uc002gul.2_Frame_Shift_Del_p.V888fs|FBXW10_uc010cqh.1_Frame_Shift_Del_p.V826fs|FAM18B_uc002gum.2_5'Flank	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	879_880										ovary(1)	1						CTATAGATGTGAAACGAACCAG	0.446			NA											13	90	---	---	---	---	NA	NA	NA	NA	NA
DDA1	79016	broad.mit.edu	37	19	17426798	17426799	+	Frame_Shift_Ins	INS	-	-	A	rs148196076	by1000genomes	TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:17426798_17426799insA	uc002ngd.2	+	4	319_320	c.192_193insA	c.(190-195)GACAAAfs	p.D64fs	DDA1_uc002nge.2_Frame_Shift_Ins_p.Q3fs	NM_024050	NP_076955	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1	64_65										ovary(1)	1						AGCAATGGGACAAAAAGGTGAG	0.347			NA											31	221	---	---	---	---	NA	NA	NA	NA	NA
ZNF99	7652	broad.mit.edu	37	19	22939803	22939804	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr19:22939803_22939804delGA	uc010xrh.1	-	6	2527_2528	c.2527_2528delTC	c.(2527-2529)TCAfs	p.S843fs		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CCTAAGGGCTGAGAAATTGCTA	0.347			NA											15	99	---	---	---	---	NA	NA	NA	NA	NA
PAK7	57144	broad.mit.edu	37	20	9561157	9561158	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:9561157_9561158insT	uc002wnl.2	-	5	1169_1170	c.624_625insA	c.(622-627)AAACCAfs	p.K208fs	PAK7_uc002wnk.2_Frame_Shift_Ins_p.K208fs|PAK7_uc002wnj.2_Frame_Shift_Ins_p.K208fs|PAK7_uc010gby.1_Frame_Shift_Ins_p.K208fs	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	208_209	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TATTCACTTGGTTTGCTCAGTG	0.47			NA											7	106	---	---	---	---	NA	NA	NA	NA	NA
ZNF831	128611	broad.mit.edu	37	20	57768672	57768672	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr20:57768672delA	uc002yan.2	+	1	2598	c.2598delA	c.(2596-2598)CCAfs	p.P866fs		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	866						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGAGGTGCCAGGGGGCTCAA	0.652			NA											10	62	---	---	---	---	NA	NA	NA	NA	NA
CDH10	1008	broad.mit.edu	37	5	24537496	24537497	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:24537496_24537497delAG	uc003jgr.1	-	3	850_851	c.518_519delCT	c.(517-519)TCTfs	p.S173fs	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	173	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S173P(1)		ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TACCTACAACAGACATTTCGGG	0.322			NA								HNSCC(23;0.051)			13	153	---	---	---	---	NA	NA	NA	NA	NA
FAT2	2196	broad.mit.edu	37	5	150925237	150925237	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr5:150925237delG	uc003lue.3	-	9	5464	c.5451delC	c.(5449-5451)CCCfs	p.P1817fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1817	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCCCATGCTGGGATCAATTT	0.423			NA											9	51	---	---	---	---	NA	NA	NA	NA	NA
ZNF184	7738	broad.mit.edu	37	6	27419414	27419415	+	Frame_Shift_Ins	INS	-	-	G			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:27419414_27419415insG	uc003njj.2	-	5	2734_2735	c.1923_1924insC	c.(1921-1926)CCCTACfs	p.P641fs	ZNF184_uc010jqv.2_Frame_Shift_Ins_p.P641fs|ZNF184_uc003nji.2_Frame_Shift_Ins_p.P641fs	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	641_642	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTACACTGGTAGGGTTTTTCTT	0.426			NA											8	95	---	---	---	---	NA	NA	NA	NA	NA
HLA-F	3134	broad.mit.edu	37	6	29694802	29694803	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr6:29694802_29694803insT	uc003nno.3	+	7	1303_1304	c.1179_1180insT	c.(1177-1182)TTGTTTfs	p.L393fs	HLA-F_uc011dlx.1_Intron|HLA-F_uc011dly.1_Intron|LOC285830_uc003nnp.2_RNA|LOC285830_uc011dlz.1_RNA	NM_001098479	NP_001091949	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	Error:Variant_position_missing_in_P30511_after_alignment					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						TGTGGATCTTGTTTTTTTTGTG	0.535			NA											8	246	---	---	---	---	NA	NA	NA	NA	NA
HDAC9	9734	broad.mit.edu	37	7	18869149	18869149	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:18869149delG	uc003suh.2	+	18	2476	c.2435delG	c.(2434-2436)AGCfs	p.S812fs	HDAC9_uc003sue.2_Frame_Shift_Del_p.S812fs|HDAC9_uc011jyd.1_Frame_Shift_Del_p.S812fs|HDAC9_uc003sui.2_Frame_Shift_Del_p.S815fs|HDAC9_uc003suj.2_Frame_Shift_Del_p.S771fs|HDAC9_uc003suk.2_Frame_Shift_Del_p.S60fs	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	812	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CTAAATATAAGCAAGATATTG	0.383			NA											7	68	---	---	---	---	NA	NA	NA	NA	NA
PCLO	27445	broad.mit.edu	37	7	82544780	82544780	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:82544780delT	uc003uhx.2	-	7	12811	c.12522delA	c.(12520-12522)CAAfs	p.Q4174fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.Q4174fs|PCLO_uc010lec.2_Frame_Shift_Del_p.Q1139fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4105					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTTTTGCTGCTTGTTTTTCAA	0.363			NA											14	87	---	---	---	---	NA	NA	NA	NA	NA
OR2F2	135948	broad.mit.edu	37	7	143632642	143632642	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:143632642delC	uc011ktv.1	+	1	317	c.317delC	c.(316-318)GCCfs	p.A106fs		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TTCTCCCTGGCCTTGGGTGGG	0.547			NA											17	98	---	---	---	---	NA	NA	NA	NA	NA
GIMAP5	55340	broad.mit.edu	37	7	150440086	150440087	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr7:150440086_150440087insA	uc003whr.1	+	3	1211_1212	c.859_860insA	c.(859-861)GTTfs	p.V287fs	GIMAP5_uc010lpu.2_Frame_Shift_Ins_p.V145fs	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	287	Helical; Anchor for type IV membrane protein; (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGAGATTTTTGTTTTTCTATTG	0.396			NA											7	58	---	---	---	---	NA	NA	NA	NA	NA
TRPA1	8989	broad.mit.edu	37	8	72951251	72951251	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:72951251delC	uc003xza.2	-	19	2319	c.2144delG	c.(2143-2145)GGAfs	p.G715fs	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	715	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AGCTCTAAATCCATAAGCCAA	0.333			NA											12	118	---	---	---	---	NA	NA	NA	NA	NA
FER1L6	654463	broad.mit.edu	37	8	125022845	125022846	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:125022845_125022846insT	uc003yqw.2	+	14	1918_1919	c.1712_1713insT	c.(1711-1713)TATfs	p.Y571fs	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	571	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AATTACAACTATTTGCCATTTG	0.455			NA											39	126	---	---	---	---	NA	NA	NA	NA	NA
ZNF572	137209	broad.mit.edu	37	8	125989900	125989900	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chr8:125989900delG	uc003yrr.2	+	3	1545	c.1390delG	c.(1390-1392)GGGfs	p.G464fs		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GACCCACATAGGGGAAAAACC	0.448			NA								HNSCC(60;0.17)			7	215	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	X	80185567	80185567	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5049-01A-01D-1625-08	TCGA-50-5049-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	96358297-0735-4eab-a01c-a6be5d86a3de	b648ea4e-b769-4d06-a274-5cf980b6e7bd	g.chrX:80185567delG	uc004eec.1	+	1	640	c.466delG	c.(466-468)GGCfs	p.G156fs						SubName: Full=cDNA FLJ16670 fis, clone THYMU3001133, highly similar to Voltage-dependent anion-selective channel protein 1; SubName: Full=Voltage-dependent anion channel 1, isoform CRA_a;												NA						GACAGAGTTTGGCGGCTCCAT	0.478			NA											9	25	---	---	---	---	NA	NA	NA	NA	NA
