Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPSB1	80176	broad.mit.edu	37	1	9416202	9416202	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:9416202G>T	uc010oae.1	+	2	591	c.252G>T	c.(250-252)ACG>ACT	p.T84T	SPSB1_uc001apv.2_Silent_p.T84T	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	84	B30.2/SPRY.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		CCCAGAGCACGGACGCTATCA	0.602			NA											35	184					5.43694e-19	9.14905e-19	0.005524	1	0
ZNF642	339559	broad.mit.edu	37	1	40961204	40961204	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:40961204G>A	uc001cfo.2	+	6	1348	c.1054G>A	c.(1054-1056)GAG>AAG	p.E352K	ZNF642_uc009vwb.2_Missense_Mutation_p.E352K|ZNF642_uc010ojk.1_Missense_Mutation_p.E353K	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			TCACACTGGGGAGAAACCCTA	0.418			NA											15	110					0	0	0.004007	0	0
CYP4X1	260293	broad.mit.edu	37	1	47489621	47489621	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:47489621C>A	uc001cqt.2	+	1	382	c.132C>A	c.(130-132)CGC>CGA	p.R44R	CYP4X1_uc001cqr.2_Intron|CYP4X1_uc001cqs.2_Intron	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	44						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						GGGACCTGCGCCCCTTCCCAG	0.488			NA											5	27					0.000602214	0.000699466	0.000602	1	0
RAB3B	5865	broad.mit.edu	37	1	52403027	52403027	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:52403027T>A	uc001cth.2	-	3	411	c.286A>T	c.(286-288)ATG>TTG	p.M96L		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	96					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						ATGAAGCCCATGGCCCCACGG	0.433			NA											15	114					0	0	0.00499	0	0
USP1	7398	broad.mit.edu	37	1	62915921	62915921	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:62915921G>A	uc001daj.1	+	9	1955	c.1627G>A	c.(1627-1629)GAT>AAT	p.D543N	USP1_uc001dak.1_Missense_Mutation_p.D543N|USP1_uc001dal.1_Missense_Mutation_p.D543N	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	543					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		CCAAAGGTTTGATTGTTATGG	0.363	Ovarian(122;1846 2315 3982 19504)		NA											7	109					0	0	0.004482	0	0
NEGR1	257194	broad.mit.edu	37	1	72400931	72400931	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:72400931C>A	uc001dfw.2	-	2	340	c.240G>T	c.(238-240)GCG>GCT	p.A80A	NEGR1_uc001dfv.2_5'UTR|NEGR1_uc010oqs.1_Silent_p.A80A	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	80	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TATCACCTCCCGCAAAAATAA	0.398			NA											15	67					4.7546e-09	6.94618e-09	0.004007	1	0
COL11A1	1301	broad.mit.edu	37	1	103428231	103428231	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:103428231G>T	uc001dul.2	-	39	3320	c.3002C>A	c.(3001-3003)GCT>GAT	p.A1001D	COL11A1_uc001duk.2_Missense_Mutation_p.A197D|COL11A1_uc001dum.2_Missense_Mutation_p.A1013D|COL11A1_uc001dun.2_Missense_Mutation_p.A962D|COL11A1_uc009weh.2_Missense_Mutation_p.A885D	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1001	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTTTCCTGCAGCACCAGGAAG	0.473			NA											19	87					6.33239e-15	1.01499e-14	0.010504	1	0
SYT6	148281	broad.mit.edu	37	1	114682455	114682455	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:114682455A>G	uc001eev.2	-	2	289	c.39T>C	c.(37-39)TCT>TCC	p.S13S		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	98	Cytoplasmic (Potential).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGGATTAGCAGAAGAGGGAC	0.597			NA											10	189					0	0	0.001368	0	0
IGSF3	3321	broad.mit.edu	37	1	117127643	117127643	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:117127643C>A	uc001egr.1	-	9	3177	c.2472G>T	c.(2470-2472)GGG>GGT	p.G824G	IGSF3_uc001egq.1_Silent_p.G844G|IGSF3_uc001egs.1_Silent_p.G497G	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	824	Ig-like C2-type 7.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CCGACAGGTTCCCCTGGGCTT	0.562			NA											10	42					3.86212e-05	4.79347e-05	0.008291	1	0
PTGFRN	5738	broad.mit.edu	37	1	117504136	117504136	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:117504136A>G	uc001egv.1	+	5	1622	c.1485A>G	c.(1483-1485)ACA>ACG	p.T495T		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	495	Extracellular (Potential).|Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		AGGAACATACAGACACGTTCA	0.493			NA											16	55					0	0	0.003163	0	0
HMGCS2	3158	broad.mit.edu	37	1	120298057	120298057	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:120298057G>C	uc001eid.2	-	6	1231	c.1180C>G	c.(1180-1182)CTG>GTG	p.L394V	HMGCS2_uc010oxj.1_Missense_Mutation_p.L352V|HMGCS2_uc001eie.2_Missense_Mutation_p.L302V	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	394					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		CACTGGGACAGAAGCGAGGCC	0.552			NA											72	278					0	0	0.00361	0	0
NBPF7	343505	broad.mit.edu	37	1	120384050	120384050	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:120384050C>G	uc010oxk.1	-	3	1133	c.512G>C	c.(511-513)GGG>GCG	p.G171A		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	171						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		CAGCCTACACCCCTCAGCCAG	0.587			NA											22	119					0	0	0.001882	0	0
GJA8	2703	broad.mit.edu	37	1	147381011	147381011	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:147381011G>T	uc001epu.1	+	2	992	c.929G>T	c.(928-930)GGG>GTG	p.G310V		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	310	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GGACCCCTGGGGGACTTGTCC	0.617	Melanoma(76;1255 1795 8195 52096)		NA											6	30					0.00116845	0.00133503	0.001168	1	0
FLG	2312	broad.mit.edu	37	1	152276020	152276020	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:152276020G>T	uc001ezu.1	-	3	11378	c.11342C>A	c.(11341-11343)TCT>TAT	p.S3781Y		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3781	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGTGTCCAGACCTATCTAC	0.577			NA							Ichthyosis				137	412					5.26942e-46	9.3549e-46	0.00361	1	0
FLG2	388698	broad.mit.edu	37	1	152325492	152325492	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:152325492G>C	uc001ezw.3	-	3	4843	c.4770C>G	c.(4768-4770)CAC>CAG	p.H1590Q	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1590							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGTGGTCTGTGTGAGCCCC	0.512			NA											46	286					0	0	0.002522	0	0
LCE2C	353140	broad.mit.edu	37	1	152648533	152648533	+	Silent	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:152648533C>G	uc001fah.2	+	2	97	c.42C>G	c.(40-42)CCC>CCG	p.P14P		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	14	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCCcctcccaagtgtcctc	0.338			NA											21	109					0	0	0.00278	0	0
SLC39A1	27173	broad.mit.edu	37	1	153932916	153932916	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:153932916G>A	uc001fdh.2	-	4	802	c.633C>T	c.(631-633)TGC>TGT	p.C211C	CRTC2_uc010ped.1_5'Flank|SLC39A1_uc001fdi.2_Silent_p.C211C|SLC39A1_uc001fdj.2_Silent_p.C211C|SLC39A1_uc001fdk.2_Silent_p.C211C|SLC39A1_uc010pee.1_Silent_p.C109C|SLC39A1_uc001fdl.2_Silent_p.C211C	NM_014437	NP_055252	Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter),	211	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		GCAAAGCCAGGCACAGCTCCA	0.662			NA											3	43					0	0	0.004672	0	0
CD5L	922	broad.mit.edu	37	1	157805847	157805847	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:157805847C>A	uc001frk.3	-	3	297	c.154G>T	c.(154-156)GGC>TGC	p.G52C		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	52	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ATGTCCCAGCCGTCATCACAC	0.617			NA											28	139					2.41591e-17	3.97456e-17	0.004656	1	0
SPTA1	6708	broad.mit.edu	37	1	158627350	158627350	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:158627350G>T	uc001fst.1	-	19	2921	c.2722C>A	c.(2722-2724)CTG>ATG	p.L908M		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	908	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCTTCATGCAGGTCAGCCAGG	0.483			NA											28	148					1.2476e-16	2.0346e-16	0.00632	1	0
SPTA1	6708	broad.mit.edu	37	1	158632506	158632506	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:158632506G>C	uc001fst.1	-	17	2649	c.2450C>G	c.(2449-2451)ACT>AGT	p.T817S		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	817	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTAGGTGGAAGTAGCTGAGGG	0.498			NA											4	69					0	0	0.009096	0	0
OR6K2	81448	broad.mit.edu	37	1	158670176	158670176	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:158670176C>T	uc001fsu.1	-	1	267	c.267G>A	c.(265-267)AGG>AGA	p.R89R		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGGAAATGCTCCTCTCACTAA	0.458			NA											15	82					0	0	0.004007	0	0
FCER1A	2205	broad.mit.edu	37	1	159275977	159275977	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:159275977G>T	uc001ftq.2	+	5	630	c.531G>T	c.(529-531)ACG>ACT	p.T177T		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	177	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	ACTACTGTACGGGCAAAGTGT	0.438			NA											32	81					2.08457e-15	3.36047e-15	0.002096	1	0
VANGL2	57216	broad.mit.edu	37	1	160388876	160388876	+	Nonsense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:160388876A>T	uc001fwb.1	+	5	576	c.277A>T	c.(277-279)AAG>TAG	p.K93*	VANGL2_uc001fwc.1_Nonsense_Mutation_p.K93*	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	93	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACGCATCGCCAAGGACATGGA	0.612			NA											6	124					0	0	0.001168	0	0
ASTN1	460	broad.mit.edu	37	1	176863929	176863929	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:176863929T>A	uc001glc.2	-	17	2921	c.2709A>T	c.(2707-2709)AGA>AGT	p.R903S	ASTN1_uc001glb.1_Missense_Mutation_p.R903S|ASTN1_uc001gld.1_Missense_Mutation_p.R903S	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	911					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CCTTGGGGTCTCTTTCCCGCT	0.522			NA											41	158					0	0	0.00361	0	0
TPR	7175	broad.mit.edu	37	1	186286693	186286693	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:186286693C>G	uc001grv.2	-	49	7158	c.6861G>C	c.(6859-6861)CAG>CAC	p.Q2287H		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	2287					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GCTCTTCTTCCTGCTGGCTAT	0.438			NA	T	NTRK1	papillary thyroid								13	59					0	0	0.00245	0	0
CFHR2	3080	broad.mit.edu	37	1	196928191	196928191	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:196928191C>A	uc001gtq.1	+	5	871	c.794C>A	c.(793-795)CCC>CAC	p.P265H	CFHR2_uc001gtr.1_Missense_Mutation_p.P141H	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	265	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						CTGGTATATCCCAGTTGTGAA	0.303			NA											10	53					3.07112e-06	4.11193e-06	0.000978	1	0
LRRN2	10446	broad.mit.edu	37	1	204588512	204588512	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:204588512G>T	uc001hbe.1	-	3	997	c.609C>A	c.(607-609)GCC>GCA	p.A203A	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Silent_p.A203A|LRRN2_uc009xbf.1_Silent_p.A203A|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	203	Extracellular (Potential).|LRR 6.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TGTCCAGGATGGCATCTACCT	0.582			NA											17	63					2.48551e-13	3.9278e-13	0.00499	1	0
MARK1	4139	broad.mit.edu	37	1	220752872	220752872	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:220752872G>T	uc001hmn.3	+	2	825	c.228G>T	c.(226-228)TTG>TTT	p.L76F	MARK1_uc001hml.2_Missense_Mutation_p.L76F|MARK1_uc009xdw.2_Missense_Mutation_p.L76F|MARK1_uc010pun.1_Missense_Mutation_p.L76F|MARK1_uc001hmm.3_Missense_Mutation_p.L76F	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	76	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		AAGTCAAATTGGCAAGACACG	0.408			NA											12	68					1.49906e-05	1.92884e-05	0.00245	1	0
OBSCN	84033	broad.mit.edu	37	1	228471364	228471364	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:228471364G>T	uc009xez.1	+	33	8942	c.8898G>T	c.(8896-8898)GAG>GAT	p.E2966D	OBSCN_uc001hsn.2_Missense_Mutation_p.E2966D|OBSCN_uc001hsp.1_Missense_Mutation_p.E665D|OBSCN_uc001hsq.1_Missense_Mutation_p.E222D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2966	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCAGCCAGGAGGGCCTGACCC	0.667			NA											20	39					8.00594e-06	1.05678e-05	0.007413	1	0
DISC1	27185	broad.mit.edu	37	1	232172460	232172460	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:232172460G>A	uc001huz.2	+	13	2501	c.2448G>A	c.(2446-2448)CAG>CAA	p.Q816Q	DISC1_uc001hva.2_Silent_p.Q794Q	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	816	Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Interaction with NDEL1.|Interaction with ATF4 and ATF5.|Interaction with PAFAH1B1.|Potential.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GGGAGCTCCAGATGGTGAAGG	0.582			NA											3	18					0	0	0.004672	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394396	233394396	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:233394396G>A	uc001hvl.2	-	5	1447	c.1212C>T	c.(1210-1212)ACC>ACT	p.T404T	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	404						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				ACTTTACACTGGTCTTCTCTG	0.527			NA											7	130					0	0	0.001984	0	0
LYST	1130	broad.mit.edu	37	1	235860531	235860531	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:235860531G>A	uc001hxj.2	-	46	10591	c.10416C>T	c.(10414-10416)TAC>TAT	p.Y3472Y	LYST_uc001hxi.2_Silent_p.Y696Y	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3472					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGGAACCCACGTATTCCCCCC	0.463			NA							Chediak-Higashsyndrome				7	49					0	0	0.001984	0	0
NID1	4811	broad.mit.edu	37	1	236201523	236201523	+	Missense_Mutation	SNP	G	G	A	rs142155830	byFrequency	TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:236201523G>A	uc001hxo.2	-	5	1268	c.1166C>T	c.(1165-1167)ACG>ATG	p.T389M	NID1_uc009xgd.2_Missense_Mutation_p.T389M	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	389	EGF-like 1.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GTTAGCACACGTCTGGCGGGA	0.552			NA											5	109					0	0	0.000602	0	0
RYR2	6262	broad.mit.edu	37	1	237551440	237551440	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:237551440T>A	uc001hyl.1	+	10	850	c.730T>A	c.(730-732)TGT>AGT	p.C244S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	244	Cytoplasmic (By similarity).|MIR 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATGGACGAGTGTCTCACTGT	0.443			NA											11	33					0	0	0.008291	0	0
GREM2	64388	broad.mit.edu	37	1	240656352	240656352	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:240656352G>T	uc001hys.2	-	2	704	c.424C>A	c.(424-426)CCA>ACA	p.P142T		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	142	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CGGAAGGGTGGGTCCAGGCCG	0.642			NA											23	81					1.33986e-20	2.30571e-20	0.004656	1	0
PLD5	200150	broad.mit.edu	37	1	242383324	242383324	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:242383324C>A	uc001hzn.1	-	5	828	c.701G>T	c.(700-702)GGC>GTC	p.G234V	PLD5_uc001hzl.3_Missense_Mutation_p.G172V|PLD5_uc001hzm.3_Missense_Mutation_p.G24V|PLD5_uc001hzo.1_Missense_Mutation_p.G142V			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	234	PLD phosphodiesterase 1.					integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			ACCGGCACTGCCGATATACAC	0.517			NA											10	56					3.86212e-05	4.79347e-05	0.008291	1	0
PLD5	200150	broad.mit.edu	37	1	242383405	242383405	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:242383405G>A	uc001hzn.1	-	5	747	c.620C>T	c.(619-621)ACG>ATG	p.T207M	PLD5_uc001hzl.3_Missense_Mutation_p.T145M|PLD5_uc001hzm.3_Translation_Start_Site|PLD5_uc001hzo.1_Missense_Mutation_p.T115M			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	207						integral to membrane	catalytic activity	p.T115M(1)		ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GTTCATGTACGTCACCTCGGC	0.557			NA											18	54					0	0	0.00499	0	0
PLD5	200150	broad.mit.edu	37	1	242428646	242428646	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:242428646T>A	uc001hzn.1	-	4	727	c.600A>T	c.(598-600)AAA>AAT	p.K200N	PLD5_uc001hzl.3_Missense_Mutation_p.K138N|PLD5_uc001hzm.3_5'UTR|PLD5_uc001hzo.1_Missense_Mutation_p.K108N			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	200						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TACCCTTTAATTTCAAGGCTT	0.333			NA											8	104					0	0	0.006214	0	0
KIF26B	55083	broad.mit.edu	37	1	245850143	245850143	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:245850143C>A	uc001ibf.1	+	12	4298	c.3858C>A	c.(3856-3858)AGC>AGA	p.S1286R	KIF26B_uc001ibg.1_Missense_Mutation_p.S904R|KIF26B_uc001ibh.1_Missense_Mutation_p.S528R	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1286					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GCGAGATGAGCGCGGGCAGTG	0.602			NA											4	23					3.59834e-05	4.51603e-05	0.001168	1	0
SCCPDH	51097	broad.mit.edu	37	1	246927551	246927551	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:246927551G>A	uc001ibr.2	+	10	1341	c.994G>A	c.(994-996)GAT>AAT	p.D332N		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	332						midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		TTCACAGATTGATGCTGCCTC	0.403			NA											12	92					0	0	0.001368	0	0
NLRP3	114548	broad.mit.edu	37	1	247588044	247588044	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:247588044C>A	uc001icr.2	+	5	1437	c.1299C>A	c.(1297-1299)GCC>GCA	p.A433A	NLRP3_uc001ics.2_Silent_p.A433A|NLRP3_uc001icu.2_Silent_p.A433A|NLRP3_uc001icw.2_Silent_p.A433A|NLRP3_uc001icv.2_Silent_p.A433A|NLRP3_uc010pyw.1_Silent_p.A431A|NLRP3_uc001ict.1_Silent_p.A431A	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	433	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGAGCCTTGCCCAGACATCCA	0.602			NA											15	34					2.32078e-09	3.44434e-09	0.003163	1	0
OR2W3	343171	broad.mit.edu	37	1	248059379	248059379	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:248059379T>A	uc001idp.1	+	3	760	c.491T>A	c.(490-492)CTG>CAG	p.L164Q	OR2W3_uc010pzb.1_Missense_Mutation_p.L164Q	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCTGTGACCCTGCGCTTACCC	0.642			NA											14	58					0	0	0.003163	0	0
OR2M4	26245	broad.mit.edu	37	1	248402653	248402653	+	Silent	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:248402653T>C	uc010pzh.1	+	1	423	c.423T>C	c.(421-423)TGT>TGC	p.C141C		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CGAAACTCTGTGTCTTCATGA	0.468			NA											18	134					0	0	0.006122	0	0
OR2T6	254879	broad.mit.edu	37	1	248550949	248550949	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:248550949C>T	uc001iei.1	+	1	40	c.40C>T	c.(40-42)CTC>TTC	p.L14F		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGCTTTACCCTCATGGGGCT	0.418			NA											50	103					0	0	0.00361	0	0
KIN	22944	broad.mit.edu	37	10	7804421	7804421	+	Silent	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:7804421T>A	uc001ijt.2	-	11	1065	c.1017A>T	c.(1015-1017)CCA>CCT	p.P339P	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Silent_p.P339P|KIN_uc010qba.1_Silent_p.P233P	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	339					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CAGATTTACCTGGTGCTGGAA	0.363			NA											12	106					0	0	0.001368	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290756	15290756	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:15290756G>T	uc001iob.2	-	5	643	c.636C>A	c.(634-636)AGC>AGA	p.S212R		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	212	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						TTCCATTACTGCTCAGCAAGT	0.572			NA											9	56					0.000274275	0.000324617	0.004482	1	0
ITGA8	8516	broad.mit.edu	37	10	15639265	15639265	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:15639265C>G	uc001ioc.1	-	21	2152	c.2152G>C	c.(2152-2154)GAA>CAA	p.E718Q	ITGA8_uc010qcb.1_Missense_Mutation_p.E703Q	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	718	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GTTACATTTTCCATCTTGTAC	0.448			NA											6	106					0	0	0.001984	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17362912	17362912	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:17362912G>C	uc001ipd.2	-	8	1162	c.1162C>G	c.(1162-1164)CTC>GTC	p.L388V	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	388	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						TGCAGTTTGAGGATTCCTTTC	0.363			NA											22	271					0	0	0.00278	0	0
NSUN6	221078	broad.mit.edu	37	10	18940128	18940128	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:18940128G>C	uc010qcp.1	-	1	423	c.5C>G	c.(4-6)TCT>TGT	p.S2C		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	2							methyltransferase activity|RNA binding			ovary(2)	2						AGGGAAAATAGACATTTTTCC	0.343			NA											9	102					0	0	0.000978	0	0
SLC18A3	6572	broad.mit.edu	37	10	50820036	50820036	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:50820036A>T	uc001jhw.2	+	1	1690	c.1250A>T	c.(1249-1251)TAT>TTT	p.Y417F	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	417	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GTCTCAGTCTATGGCAGCGTC	0.612			NA											3	21					0	0	0.004672	0	0
PCDH15	65217	broad.mit.edu	37	10	55582022	55582022	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:55582022G>C	uc001jju.1	-	33	5859	c.5464C>G	c.(5464-5466)CCT>GCT	p.P1822A	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P1819A|PCDH15_uc010qhw.1_Missense_Mutation_p.P1782A|PCDH15_uc010qhx.1_Missense_Mutation_p.P1753A|PCDH15_uc010qhy.1_Missense_Mutation_p.P1829A|PCDH15_uc010qhz.1_Missense_Mutation_p.P1824A|PCDH15_uc010qia.1_Missense_Mutation_p.P1802A|PCDH15_uc010qib.1_Missense_Mutation_p.P1799A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1822	Poly-Pro.|Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				atagaaggaggtggtggagga	0.249			NA								HNSCC(58;0.16)			4	59					0	0	0.009096	0	0
MYPN	84665	broad.mit.edu	37	10	69957180	69957180	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:69957180A>C	uc001jnm.3	+	17	3415	c.3230A>C	c.(3229-3231)CAG>CCG	p.Q1077P	MYPN_uc001jnn.3_Missense_Mutation_p.Q802P|MYPN_uc001jno.3_Missense_Mutation_p.Q1077P|MYPN_uc009xpt.2_Missense_Mutation_p.Q1077P|MYPN_uc010qit.1_Missense_Mutation_p.Q783P|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	1077	Ig-like 4.|Interaction with ACTN.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CATTTCCTGCAGGCTCCTGGG	0.488			NA											14	168					0	0	0.004007	0	0
SAR1A	56681	broad.mit.edu	37	10	71913618	71913618	+	Silent	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:71913618C>G	uc010qjh.1	-	7	659	c.456G>C	c.(454-456)GGG>GGC	p.G152G	SAR1A_uc010qji.1_Silent_p.G152G|SAR1A_uc010qjj.1_Silent_p.G109G	NM_001142648	NP_001136120	Q9NR31	SAR1A_HUMAN	SAR1a gene homolog 1	152					ER to Golgi vesicle-mediated transport|intracellular protein transport	Golgi apparatus	GTP binding|GTPase activity				0						GTCCATAAAGCCCAAATATCT	0.343			NA											16	352					0	0	0.00499	0	0
FUT11	170384	broad.mit.edu	37	10	75533453	75533453	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:75533453A>T	uc001jva.2	+	2	1257	c.1214A>T	c.(1213-1215)CAC>CTC	p.H405L	FUT11_uc001juy.1_3'UTR|FUT11_uc001juz.1_Missense_Mutation_p.H405L	NM_173540	NP_775811	Q495W5	FUT11_HUMAN	fucosyltransferase 11 (alpha (1,3)	405	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	Prostate(51;0.0112)					GAGAAAGCCCACGCGGCCTCT	0.597			NA											7	76					0	0	0.001984	0	0
HECTD2	143279	broad.mit.edu	37	10	93220264	93220264	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:93220264G>T	uc001khl.2	+	3	449	c.349G>T	c.(349-351)GCC>TCC	p.A117S	LOC100188947_uc010qnl.1_Intron|HECTD2_uc001khk.2_Missense_Mutation_p.A117S|HECTD2_uc010qnm.1_Missense_Mutation_p.A117S|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'Flank	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	117					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						CGAAATGAAGGCCCCAGTCCT	0.393	NSCLC(12;376 469 1699 39910 41417)		NA											30	125					2.4375e-19	4.13123e-19	0.007291	1	0
BTRC	8945	broad.mit.edu	37	10	103292158	103292158	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:103292158T>C	uc001kta.2	+	8	1060	c.947T>C	c.(946-948)ATA>ACA	p.I316T	BTRC_uc001ktb.2_Missense_Mutation_p.I280T|BTRC_uc001ktc.2_Missense_Mutation_p.I290T	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	316	WD 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		GATCAGAAAATAGTAAGCGGC	0.413			NA											10	112					0	0	0.000978	0	0
CCDC147	159686	broad.mit.edu	37	10	106209934	106209934	+	Missense_Mutation	SNP	G	G	T	rs138183014		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:106209934G>T	uc001kyh.2	+	17	2616	c.2482G>T	c.(2482-2484)GCT>TCT	p.A828S		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	828	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAAATACCTCGCTCAGAAACG	0.323			NA											17	80					3.45872e-05	4.40986e-05	0.004007	1	0
SORCS1	114815	broad.mit.edu	37	10	108923853	108923853	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:108923853C>G	uc001kym.2	-	1	440	c.432G>C	c.(430-432)GAG>GAC	p.E144D	SORCS1_uc001kyl.2_Missense_Mutation_p.E144D|SORCS1_uc009xxs.2_Missense_Mutation_p.E144D|SORCS1_uc001kyn.1_Missense_Mutation_p.E144D|SORCS1_uc001kyo.2_Missense_Mutation_p.E144D	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	144	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCGGGTCCCGCTCCCGAGTCC	0.662			NA											6	39					0	0	0.00308	0	0
HABP2	3026	broad.mit.edu	37	10	115334134	115334134	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:115334134C>A	uc001lai.3	+	3	296	c.193C>A	c.(193-195)CCT>ACT	p.P65T	HABP2_uc010qrz.1_RNA|HABP2_uc010qry.1_Silent_p.I53I	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	65					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		CGCTGAGAATCCTGACTGGTA	0.507			NA											18	95					1.99824e-07	2.78858e-07	0.00499	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118220524	118220524	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:118220524C>A	uc001lcl.3	+	6	713	c.612C>A	c.(610-612)GTC>GTA	p.V204V		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	204					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		CAAAGGAAGTCAGGCTAGACC	0.438			NA											12	76					4.36969e-10	6.58978e-10	0.001855	1	0
PNLIPRP1	5407	broad.mit.edu	37	10	118360618	118360618	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:118360618C>T	uc001lco.1	+	10	986	c.968C>T	c.(967-969)CCA>CTA	p.P323L	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.P323L	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	323					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		CAAGGATGCCCACAGATGGGT	0.443			NA											5	118					0	0	0.001984	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118386413	118386414	+	Missense_Mutation	DNP	GG	GG	CA			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:118386413_118386414GG>CA	uc001lcq.2	+	7	395_396	c.372_373GG>CA	c.(370-375)GTGGAC>GTCAAC	p.D125N	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	124					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		GCATCTGTGTGGACTGGAGGCA	0.505			NA											3	18					0	0	0.004672	0	0
DMBT1	1755	broad.mit.edu	37	10	124345771	124345771	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr10:124345771G>T	uc001lgk.1	+	16	1761	c.1655G>T	c.(1654-1656)GGC>GTC	p.G552V	DMBT1_uc001lgl.1_Missense_Mutation_p.G542V|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.G552V|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	552	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTTGGTCAGGGCTCAGGACCC	0.592	Ovarian(182;93 2026 18125 22222 38972)		NA											20	187					1.37522e-17	2.28255e-17	0.007413	1	0
PSMD13	5719	broad.mit.edu	37	11	249047	249047	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:249047G>T	uc001lol.2	+	9	1006	c.764G>T	c.(763-765)TGG>TTG	p.W255L	PSMD13_uc010qvr.1_RNA|PSMD13_uc001loo.2_Missense_Mutation_p.W257L|PSMD13_uc001lon.2_Missense_Mutation_p.W190L|PSMD13_uc001lom.2_Missense_Mutation_p.W230L|PSMD13_uc001lop.2_Missense_Mutation_p.W38L	NM_002817	NP_002808	Q9UNM6	PSD13_HUMAN	proteasome 26S non-ATPase subunit 13 isoform 1	255	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			ovary(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.79e-27)|Epithelial(43;4e-26)|OV - Ovarian serous cystadenocarcinoma(40;6.02e-21)|BRCA - Breast invasive adenocarcinoma(625;3.93e-05)|Lung(200;0.112)|LUSC - Lung squamous cell carcinoma(625;0.129)		AAGACTGCCTGGGGCCAGCAG	0.438			NA											11	31					4.3838e-07	6.07238e-07	0.001855	1	0
OR51F1	256892	broad.mit.edu	37	11	4790230	4790230	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:4790230G>A	uc010qyl.1	-	1	918	c.918C>T	c.(916-918)CTC>CTT	p.L306L		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	306						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCAGCAGACTGAGCATAGCCT	0.418			NA											6	77					0	0	0.001168	0	0
OR51F2	119694	broad.mit.edu	37	11	4843470	4843470	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:4843470T>G	uc010qyn.1	+	1	855	c.855T>G	c.(853-855)TTT>TTG	p.F285L		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	285	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACCTCCATTTGTCCACATCA	0.443			NA											16	102					0	0	0.010504	0	0
OR52B2	255725	broad.mit.edu	37	11	6191076	6191076	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:6191076C>A	uc010qzy.1	-	1	481	c.481G>T	c.(481-483)GTC>TTC	p.V161F		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGAATATGACTGGGAAGATG	0.507	NSCLC(5;186 261 1778 7098 14207)		NA											10	27					1.58986e-06	2.16484e-06	0.008291	1	0
NLRP14	338323	broad.mit.edu	37	11	7070935	7070935	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:7070935G>T	uc001mfb.1	+	6	2480	c.2157G>T	c.(2155-2157)CAG>CAT	p.Q719H		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	719					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATGGTTGTCAGGATATCTCTA	0.383			NA											33	138					4.74835e-14	7.54625e-14	0.002096	1	0
KCNA4	3739	broad.mit.edu	37	11	30032822	30032822	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:30032822G>T	uc001msk.2	-	2	2556	c.1404C>A	c.(1402-1404)GGC>GGA	p.G468G		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	468						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGAGGGTGTGGCCCAGGATCT	0.537			NA											4	74					0.00909568	0.00994674	0.009096	1	0
C11orf46	120534	broad.mit.edu	37	11	30352778	30352778	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:30352778T>G	uc001mso.1	+	2	447	c.283T>G	c.(283-285)TTA>GTA	p.L95V		NM_152316	NP_689529	Q8N8R7	CK046_HUMAN	hypothetical protein LOC120534	95											0						TGTAATTGACTTAGATGATGC	0.348			NA											9	210					0	0	0.000978	0	0
WT1	7490	broad.mit.edu	37	11	32413601	32413601	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:32413601G>T	uc001mtn.1	-	9	1545	c.1349C>A	c.(1348-1350)CCA>CAA	p.P450Q	WT1_uc001mtl.1_Missense_Mutation_p.P238Q|WT1_uc001mtm.1_Missense_Mutation_p.P221Q|WT1_uc001mto.1_Missense_Mutation_p.P450Q|WT1_uc001mtp.1_Missense_Mutation_p.P433Q|WT1_uc001mtq.1_Missense_Mutation_p.P433Q|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	382					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			ACACTGGAATGGTTTCACACC	0.522			NA	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				33	194					1.36615e-20	2.34375e-20	0.002836	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136858	40136858	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:40136858G>A	uc001mxa.1	-	2	2949	c.985C>T	c.(985-987)CGG>TGG	p.R329W	LRRC4C_uc001mxc.1_Missense_Mutation_p.R325W|LRRC4C_uc001mxd.1_Missense_Mutation_p.R325W|LRRC4C_uc001mxb.1_Missense_Mutation_p.R325W	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	329	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTGTTACACCGGGCACAACAA	0.502			NA											4	44					0	0	0.009096	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137192	40137192	+	Silent	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:40137192C>G	uc001mxa.1	-	2	2615	c.651G>C	c.(649-651)CCG>CCC	p.P217P	LRRC4C_uc001mxc.1_Silent_p.P213P|LRRC4C_uc001mxd.1_Silent_p.P213P|LRRC4C_uc001mxb.1_Silent_p.P213P	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	217	LRR 6.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTTTTATGAGCGGTGTGAGGT	0.458			NA											19	93					0	0	0.008871	0	0
OR4A47	403253	broad.mit.edu	37	11	48511136	48511136	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:48511136C>T	uc010rhx.1	+	1	792	c.792C>T	c.(790-792)CCC>CCT	p.P264P		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGACCTTCCCCATTGACAAAT	0.423			NA											13	407					0	0	0.00245	0	0
TRIM48	79097	broad.mit.edu	37	11	55032690	55032690	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:55032690G>T	uc010rid.1	+	2	445	c.359G>T	c.(358-360)TGT>TTT	p.C120F		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	104	B box-type.					intracellular	zinc ion binding				0						AAGATGTTCTGTGAAGTGGAC	0.537			NA											9	60					0.00448238	0.00502923	0.004482	1	0
TRIM48	79097	broad.mit.edu	37	11	55036774	55036774	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:55036774G>A	uc010rid.1	+	5	721	c.635G>A	c.(634-636)GGG>GAG	p.G212E		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	196						intracellular	zinc ion binding				0						CTCAGGGCAGGGCCCATCACT	0.502			NA											3	53					0	0	0.009096	0	0
OR4C15	81309	broad.mit.edu	37	11	55322383	55322383	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:55322383G>A	uc010rig.1	+	1	601	c.601G>A	c.(601-603)GCC>ACC	p.A201T		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GATGGGGGTAGCCTGGACAGG	0.473			NA								HNSCC(20;0.049)			23	79					0	0	0.00278	0	0
OR4C16	219428	broad.mit.edu	37	11	55340091	55340091	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:55340091G>T	uc010rih.1	+	1	488	c.488G>T	c.(487-489)AGT>ATT	p.S163I		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				CTTGCCCTGAGTTTGCCATTC	0.468			NA											38	156					8.16277e-20	1.39613e-19	0.006999	1	0
OR5D14	219436	broad.mit.edu	37	11	55563864	55563864	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:55563864T>A	uc010rim.1	+	1	833	c.833T>A	c.(832-834)GTA>GAA	p.V278E		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				GTGGCCTCTGTATTTTACACA	0.438			NA											4	84					0	0	0.009096	0	0
OR5I1	10798	broad.mit.edu	37	11	55703071	55703071	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:55703071G>A	uc010ris.1	-	1	806	c.806C>T	c.(805-807)TCT>TTT	p.S269F		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGTGTTTGGAGAATACAGGTA	0.408			NA											7	35					0	0	0.00308	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735247	55735247	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:55735247G>A	uc010rit.1	-	1	693	c.693C>T	c.(691-693)ACC>ACT	p.T231T		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	231	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GAGATGAGCAGGTGGAGAAGG	0.403			NA											13	54					0	0	0.001368	0	0
OR5T3	390154	broad.mit.edu	37	11	56020011	56020011	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:56020011G>T	uc010rjd.1	+	1	336	c.336G>T	c.(334-336)TTG>TTT	p.L112F		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	112	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					CAAAAATGTTGGTCAATTTCC	0.358			NA											41	154					1.57019e-19	2.66933e-19	0.007835	1	0
OR9G9	504191	broad.mit.edu	37	11	56468089	56468089	+	Missense_Mutation	SNP	T	T	A	rs62619921		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:56468089T>A	uc010rjn.1	+	1	226	c.226T>A	c.(226-228)TAC>AAC	p.Y76N		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTTCTGTCTACACCCCAAA	0.478			NA											14	81					0	0	0.003163	0	0
EFEMP2	30008	broad.mit.edu	37	11	65635362	65635362	+	Silent	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:65635362A>T	uc001ofy.3	-	10	1334	c.1140T>A	c.(1138-1140)GCT>GCA	p.A380A	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Silent_p.A380A	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	380					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GCGAGTTTCCAGCACGGATCT	0.547			NA											31	84					0	0	0.003755	0	0
DPP3	10072	broad.mit.edu	37	11	66272113	66272113	+	Missense_Mutation	SNP	G	G	C	rs35493089		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:66272113G>C	uc001oig.1	+	17	1971	c.1909G>C	c.(1909-1911)GGG>CGG	p.G637R	DPP3_uc001oif.1_Missense_Mutation_p.G637R|DPP3_uc010rpe.1_Missense_Mutation_p.G626R|DPP3_uc001oih.1_Missense_Mutation_p.E4D	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	637					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TGTGGCCGGAGGGCGGGCCCT	0.607			NA											10	86					0	0	0.008291	0	0
NUDT8	254552	broad.mit.edu	37	11	67395479	67395479	+	Nonsense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:67395479T>A	uc001omo.1	-	4	668	c.649A>T	c.(649-651)AAG>TAG	p.K217*	NUDT8_uc001omn.2_3'UTR	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	217						mitochondrion	hydrolase activity|metal ion binding				0						AGGGGCTGCTTAGGGCGGGCC	0.617			NA											7	23					0	0	0.00308	0	0
TRIM49	57093	broad.mit.edu	37	11	89537473	89537473	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:89537473G>A	uc001pdb.2	-	3	494	c.165C>T	c.(163-165)TGC>TGT	p.C55C		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	55	RING-type.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTGACTTTGTGCATTCAGAGC	0.468			NA											17	92					0	0	0.00278	0	0
FAT3	120114	broad.mit.edu	37	11	92534672	92534672	+	Silent	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:92534672C>G	uc001pdj.3	+	9	8510	c.8493C>G	c.(8491-8493)ACC>ACG	p.T2831T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2831	Cadherin 26.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTGTTGGCACCAAACTCACAC	0.448			NA								TCGA Ovarian(4;0.039)			9	7					0	0	0.004482	0	0
DIXDC1	85458	broad.mit.edu	37	11	111864309	111864309	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:111864309C>A	uc001pml.2	+	14	1659	c.1362C>A	c.(1360-1362)CAC>CAA	p.H454Q	DIXDC1_uc001pmm.2_Missense_Mutation_p.H243Q|DIXDC1_uc001pmn.2_Missense_Mutation_p.H160Q|DIXDC1_uc010rwq.1_Missense_Mutation_p.H119Q	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	454					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		TCAGTTACCACCAGGTCAGAA	0.473			NA											20	73					1.00905e-13	1.59908e-13	0.008871	1	0
DSCAML1	57453	broad.mit.edu	37	11	117310107	117310107	+	Missense_Mutation	SNP	C	C	A	rs61730454	byFrequency	TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:117310107C>A	uc001prh.1	-	23	4201	c.4199G>T	c.(4198-4200)CGG>CTG	p.R1400L		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1340	Extracellular (Potential).|Ig-like C2-type 10.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTGGATGAGCCGGTGCCCATC	0.622			NA											20	46					8.34094e-07	1.14128e-06	0.008871	1	0
OR10G4	390264	broad.mit.edu	37	11	123886884	123886884	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:123886884C>T	uc010sac.1	+	1	603	c.603C>T	c.(601-603)GAC>GAT	p.D201D		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TCTTTGTGGACATTGGGATAG	0.562			NA											16	98					0	0	0.002836	0	0
OR10G4	390264	broad.mit.edu	37	11	123886904	123886904	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:123886904G>C	uc010sac.1	+	1	623	c.623G>C	c.(622-624)GGC>GCC	p.G208A		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G208G(1)		skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGGCCTCAGGCTGCTTTGTC	0.562			NA											16	88					0	0	0.002096	0	0
FGF23	8074	broad.mit.edu	37	12	4488554	4488554	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:4488554G>T	uc001qmq.1	-	1	341	c.195C>A	c.(193-195)CCC>CCA	p.P65P		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	65					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			TGGTCTGATGGGGTGCGCCAT	0.587			NA											5	115					4.096e-09	6.01533e-09	0.001168	1	0
CD163	9332	broad.mit.edu	37	12	7639558	7639558	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:7639558G>T	uc001qsz.3	-	9	2203	c.2075C>A	c.(2074-2076)TCG>TAG	p.S692*	CD163_uc001qta.3_Nonsense_Mutation_p.S692*|CD163_uc009zfw.2_Nonsense_Mutation_p.S725*	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	692	Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGAATTGCACGAGGACAGTGT	0.438			NA											11	47					3.86212e-05	4.79347e-05	0.008291	1	0
PDE3A	5139	broad.mit.edu	37	12	20803388	20803388	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:20803388G>A	uc001reh.1	+	14	2801	c.2779G>A	c.(2779-2781)GAT>AAT	p.D927N		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	927	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTAAATGATGATGTTGGAAT	0.294			NA											145	80					0	0	0.00361	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20874923	20874923	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:20874923G>T	uc001rej.3	+	9	1316	c.961G>T	c.(961-963)GAT>TAT	p.D321Y	SLCO1C1_uc010sii.1_Missense_Mutation_p.D321Y|SLCO1C1_uc010sij.1_Missense_Mutation_p.D272Y|SLCO1C1_uc009zip.2_Missense_Mutation_p.D155Y|SLCO1C1_uc001rei.2_Missense_Mutation_p.D321Y|SLCO1C1_uc010sik.1_Missense_Mutation_p.D203Y	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	321	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TATTATAGATGATCACACAGA	0.358			NA											6	105					3.59834e-05	4.51603e-05	0.001168	1	0
SLCO1A2	6579	broad.mit.edu	37	12	21428305	21428305	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:21428305G>C	uc001rer.2	-	12	1915	c.1664C>G	c.(1663-1665)ACA>AGA	p.T555R	SLCO1A2_uc001res.2_Missense_Mutation_p.T555R|SLCO1A2_uc010siq.1_Missense_Mutation_p.T423R|SLCO1A2_uc010sio.1_Missense_Mutation_p.T423R|SLCO1A2_uc010sip.1_Missense_Mutation_p.T423R|SLCO1A2_uc001ret.2_Missense_Mutation_p.T553R	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	555	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						AAATACTCTTGTGCAAAATGT	0.214			NA											5	56					0	0	0.001984	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:25398284C>G	uc001rgp.1	-	2	216	c.35G>C	c.(34-36)GGT>GCT	p.G12A	KRAS_uc001rgq.1_Missense_Mutation_p.G12A|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			22	32					0	0	0.00278	0	0
ITPR2	3709	broad.mit.edu	37	12	26493144	26493144	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:26493144G>C	uc001rhg.2	-	56	8392	c.7975C>G	c.(7975-7977)CTG>GTG	p.L2659V		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2659	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TGTTTGACCAGACTCATGGTC	0.547			NA											11	90					0	0	0.001855	0	0
PTHLH	5744	broad.mit.edu	37	12	28116578	28116578	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:28116578G>T	uc001rik.2	-	3	530	c.227C>A	c.(226-228)TCG>TAG	p.S76*	PTHLH_uc001ril.2_Nonsense_Mutation_p.S76*|PTHLH_uc001rim.2_Nonsense_Mutation_p.S76*|PTHLH_uc001rin.2_Nonsense_Mutation_p.S76*	NM_198966	NP_945317	P12272	PTHR_HUMAN	parathyroid hormone-like hormone isoform 1	76					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)	1	Lung SC(9;0.184)					GGACACCTCCGAGGTAGCTCT	0.512			NA											22	195					3.28513e-13	5.16234e-13	0.003954	1	0
OVCH1	341350	broad.mit.edu	37	12	29614829	29614829	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:29614829G>T	uc001rix.1	-	19	2238	c.2238C>A	c.(2236-2238)ATC>ATA	p.I746I		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	746	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AGCCAGCACAGATCATCTTCT	0.458			NA											7	164					2.7689e-08	3.98295e-08	0.001984	1	0
TMTC1	83857	broad.mit.edu	37	12	29669365	29669365	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:29669365G>A	uc001rjb.2	-	15	2374	c.1900C>T	c.(1900-1902)CAC>TAC	p.H634Y	TMTC1_uc001riz.2_Missense_Mutation_p.H391Y|TMTC1_uc001rja.2_Missense_Mutation_p.H478Y|TMTC1_uc001riy.2_Missense_Mutation_p.H87Y	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	742						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GACACAATGTGATTGGTCATC	0.468			NA											63	76					0	0	0.00361	0	0
CNTN1	1272	broad.mit.edu	37	12	41337491	41337492	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:41337491_41337492GG>TT	uc001rmm.1	+	13	1585_1586	c.1472_1473GG>TT	c.(1471-1473)GGG>GTT	p.G491V	CNTN1_uc009zjy.1_Missense_Mutation_p.G491V|CNTN1_uc001rmn.1_Missense_Mutation_p.G480V|CNTN1_uc001rmo.2_Missense_Mutation_p.G491V	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	491	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AATAACAGAGGGAAAGCTAATA	0.356			NA											5	63					0	0	0.004672	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826499	43826499	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:43826499C>G	uc010skx.1	-	20	2836	c.2836G>C	c.(2836-2838)GAC>CAC	p.D946H	ADAMTS20_uc001rno.1_Missense_Mutation_p.D100H|ADAMTS20_uc001rnp.1_Missense_Mutation_p.D100H	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	946	TSP type-1 3.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CAGTAGTGGTCATCAACTTGA	0.423			NA											10	80					0	0	0.006214	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43925915	43925915	+	Missense_Mutation	SNP	G	G	T	rs80268015		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:43925915G>T	uc010skx.1	-	3	537	c.537C>A	c.(535-537)CAC>CAA	p.H179Q		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	179						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTGGCTTGTTGTGACCATCTT	0.358			NA											12	61					2.35188e-11	3.60493e-11	0.006122	1	0
OR6C6	283365	broad.mit.edu	37	12	55688106	55688106	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:55688106T>C	uc010sph.1	-	1	911	c.911A>G	c.(910-912)CAA>CGA	p.Q304R		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						CAAATTCTTTTGTAATACATC	0.303			NA											9	73					0	0	0.004482	0	0
NAV3	89795	broad.mit.edu	37	12	78452876	78452876	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:78452876G>T	uc001syp.2	+	12	2790	c.2617G>T	c.(2617-2619)GTG>TTG	p.V873L	NAV3_uc001syo.2_Missense_Mutation_p.V873L|NAV3_uc010sub.1_Missense_Mutation_p.V373L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	873						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GGTTCACGATGTGACAGTGGA	0.398			NA								HNSCC(70;0.22)			8	73					1.06961e-07	1.50767e-07	0.00308	1	0
NAV3	89795	broad.mit.edu	37	12	78511934	78511934	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:78511934C>G	uc001syp.2	+	14	3070	c.2897C>G	c.(2896-2898)TCT>TGT	p.S966C	NAV3_uc001syo.2_Missense_Mutation_p.S966C|NAV3_uc010sub.1_Missense_Mutation_p.S466C|NAV3_uc009zsf.2_5'UTR	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	966						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACTGTGTCCTCTGGACTTCCT	0.542			NA								HNSCC(70;0.22)			5	126					0	0	0.001168	0	0
NAV3	89795	broad.mit.edu	37	12	78569175	78569175	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:78569175G>C	uc001syp.2	+	25	5244	c.5071G>C	c.(5071-5073)GCC>CCC	p.A1691P	NAV3_uc001syo.2_Missense_Mutation_p.A1691P|NAV3_uc010sub.1_Missense_Mutation_p.A1177P|NAV3_uc009zsf.2_Missense_Mutation_p.A522P	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1691						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TGGTAATGATGCCGACTCCAA	0.393			NA								HNSCC(70;0.22)			5	93					0	0	0.001168	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85531700	85531700	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:85531700G>A	uc001tac.2	+	19	4393	c.4282G>A	c.(4282-4284)GAT>AAT	p.D1428N		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1428										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TGAAGAATCCGATGAAGAATA	0.299			NA											7	98					0	0	0.001984	0	0
IGF1	3479	broad.mit.edu	37	12	102813420	102813420	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:102813420C>A	uc001tjp.3	-	3	488	c.269G>T	c.(268-270)GGC>GTC	p.G90V	IGF1_uc001tjn.2_Missense_Mutation_p.G74V|IGF1_uc001tjm.2_Missense_Mutation_p.G90V|IGF1_uc001tjo.2_Missense_Mutation_p.G90V	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	90	A.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						ATCCACGATGCCTGTCTGAGG	0.572			NA											6	49					0.00116845	0.00133503	0.001168	1	0
WSCD2	9671	broad.mit.edu	37	12	108600180	108600180	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:108600180G>T	uc001tms.2	+	3	1241	c.497G>T	c.(496-498)CGG>CTG	p.R166L	WSCD2_uc001tmt.2_Missense_Mutation_p.R166L	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	166	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						TGTGCTGAACGGTAGGGTCCC	0.527			NA											4	37					1.23904e-05	1.60532e-05	0.000602	1	0
CCDC63	160762	broad.mit.edu	37	12	111296569	111296569	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:111296569T>G	uc001trv.1	+	4	554	c.359T>G	c.(358-360)CTG>CGG	p.L120R	CCDC63_uc009zvt.1_Missense_Mutation_p.L35R|CCDC63_uc010sye.1_Missense_Mutation_p.L80R|CCDC63_uc001trw.1_Missense_Mutation_p.L35R	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	120	Potential.									skin(6)|ovary(1)|pancreas(1)	8						TTGGCTGAACTGGATGAGAAG	0.483			NA											8	65					0	0	0.004482	0	0
OAS1	4938	broad.mit.edu	37	12	113344990	113344990	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:113344990G>C	uc001tud.2	+	1	252	c.146G>C	c.(145-147)AGC>ACC	p.S49T	OAS1_uc010syn.1_Missense_Mutation_p.S48T|OAS1_uc010syo.1_Missense_Mutation_p.S48T|OAS1_uc001tub.2_Missense_Mutation_p.S49T|OAS1_uc001tuc.2_Missense_Mutation_p.S49T|OAS1_uc009zwf.2_Missense_Mutation_p.S48T	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	49					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						TTCCGAGGTAGCTCCTACCCT	0.512			NA											5	74					0	0	0.001168	0	0
MED13L	23389	broad.mit.edu	37	12	116410034	116410034	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:116410034A>T	uc001tvw.2	-	26	5794	c.5739T>A	c.(5737-5739)AGT>AGA	p.S1913R		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1913					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CAAGGAGGATACTCCAATCTG	0.418			NA											10	73					0	0	0.008291	0	0
MED13L	23389	broad.mit.edu	37	12	116421096	116421096	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:116421096G>A	uc001tvw.2	-	21	4836	c.4781C>T	c.(4780-4782)CCT>CTT	p.P1594L		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1594	Ser-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GCTAATACCAGGAGCAGAGGC	0.507			NA											5	36					0	0	0.001168	0	0
CIT	11113	broad.mit.edu	37	12	120214178	120214178	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:120214178T>A	uc001txi.1	-	15	1924	c.1871A>T	c.(1870-1872)TAT>TTT	p.Y624F	CIT_uc001txh.1_Missense_Mutation_p.Y158F|CIT_uc001txj.1_Missense_Mutation_p.Y624F	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	624	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CAGTTTCGCATATTCTCCCAC	0.358			NA											48	199					0	0	0.00361	0	0
LRRC43	254050	broad.mit.edu	37	12	122684775	122684775	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:122684775G>T	uc009zxm.2	+	8	1414	c.1389G>T	c.(1387-1389)GAG>GAT	p.E463D	LRRC43_uc001ubw.3_Missense_Mutation_p.E278D|LRRC43_uc009zxn.2_Missense_Mutation_p.E224D	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	463											0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		CCTGGGCTGAGGTCATCCCCT	0.652			NA											11	57					0.000978159	0.00112448	0.000978	1	0
P2RX2	22953	broad.mit.edu	37	12	133196474	133196474	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:133196474C>A	uc001ukj.1	+	4	426	c.426C>A	c.(424-426)TGC>TGA	p.C142*	P2RX2_uc001uki.1_Nonsense_Mutation_p.C142*|P2RX2_uc001ukk.1_Nonsense_Mutation_p.C142*|P2RX2_uc001ukl.1_Nonsense_Mutation_p.C118*|P2RX2_uc001ukm.1_Intron|P2RX2_uc001ukn.1_Nonsense_Mutation_p.C50*|P2RX2_uc009zyt.1_Nonsense_Mutation_p.C142*|P2RX2_uc001uko.1_Nonsense_Mutation_p.C118*	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	142	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		ACGCCGACTGCGTGGCTGGGG	0.697			NA											4	15					0.00909568	0.00994674	0.009096	1	0
TPTE2	93492	broad.mit.edu	37	13	20024286	20024286	+	Silent	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:20024286G>C	uc001umd.2	-	14	1114	c.903C>G	c.(901-903)ACC>ACG	p.T301T	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Silent_p.T190T|TPTE2_uc001ume.2_Silent_p.T224T|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	301	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TTACTTCCTTGGTGAAAACCA	0.333			NA											11	87					0	0	0.001855	0	0
HSPH1	10808	broad.mit.edu	37	13	31711466	31711466	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:31711466C>A	uc001utj.2	-	18	2964	c.2566G>T	c.(2566-2568)GAC>TAC	p.D856Y	HSPH1_uc001utk.2_Missense_Mutation_p.D812Y|HSPH1_uc010aaw.2_Missense_Mutation_p.D815Y|HSPH1_uc001utl.2_Missense_Mutation_p.D858Y|HSPH1_uc010tds.1_Missense_Mutation_p.D780Y	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	856					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TAGTCCAAGTCCATATTAACA	0.299			NA											22	128					3.5997e-14	5.73702e-14	0.002299	1	0
ENOX1	55068	broad.mit.edu	37	13	43933986	43933986	+	Splice_Site	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:43933986C>G	uc001uza.3	-	7	889	c.589_splice	c.e7+1	p.G197_splice	ENOX1_uc001uzb.3_Splice_Site_p.G197_splice|ENOX1_uc001uzc.3_Splice_Site_p.G197_splice|ENOX1_uc010tfm.1_Splice_Site_p.G10_splice	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1						electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		ATGCAAAGTACCAGAAAGGTA	0.358			NA											7	134					0	0	0.001984	0	0
NUDT15	55270	broad.mit.edu	37	13	48619794	48619794	+	Splice_Site	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:48619794A>T	uc001vbw.1	+	3	536	c.356_splice	c.e3-2	p.S119_splice		NM_018283	NP_060753	Q9NV35	NUD15_HUMAN	nudix-type motif 15								hydrolase activity|metal ion binding				0		all_cancers(8;3.75e-25)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|all_hematologic(8;0.000219)|Lung NSC(96;0.000226)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;4.83e-07)		TTTCTTTTCTAGGTTGGGAGT	0.343			NA											4	59					0	0	0.009096	0	0
PCDH8	5100	broad.mit.edu	37	13	53422253	53422253	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:53422253C>G	uc001vhi.2	-	1	522	c.319G>C	c.(319-321)GAT>CAT	p.D107H	PCDH8_uc001vhj.2_Missense_Mutation_p.D107H	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	107	Extracellular (Potential).|Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTGACCACATCGAAGGCCAGC	0.711	GBM(36;25 841 9273 49207)		NA											4	36					0	0	0.009096	0	0
LMO7	4008	broad.mit.edu	37	13	76379705	76379705	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:76379705A>T	uc001vjv.2	+	6	1066	c.306A>T	c.(304-306)AAA>AAT	p.K102N	LMO7_uc010thv.1_Intron|LMO7_uc001vjt.1_Intron|LMO7_uc010thw.1_Intron|LMO7_uc001vjw.1_Intron	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	387						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAGAGGAAAAAGCAAAGACAA	0.428			NA											22	172					0	0	0.010504	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453826	84453826	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:84453826G>A	uc001vlk.2	-	1	2703	c.1817C>T	c.(1816-1818)TCC>TTC	p.S606F		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	606	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GTAGGAGTTGGAGTGCGTCCC	0.587			NA											3	12					0	0	0.004672	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368638	86368638	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:86368638G>C	uc001vll.1	-	2	2465	c.2006C>G	c.(2005-2007)ACT>AGT	p.T669S	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	669	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCTTTCAGTAGTGTGATGAGT	0.443			NA											33	191					0	0	0.002836	0	0
UGGT2	55757	broad.mit.edu	37	13	96519616	96519616	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:96519616T>G	uc001vmt.2	-	30	3705	c.3535A>C	c.(3535-3537)AAA>CAA	p.K1179Q		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1179					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						ATCTTGCTTTTGAAGCTGTTT	0.289			NA											9	147					0	0	0.001368	0	0
SLC15A1	6564	broad.mit.edu	37	13	99356687	99356687	+	Silent	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:99356687T>C	uc001vno.2	-	17	1349	c.1272A>G	c.(1270-1272)ACA>ACG	p.T424T		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	424	Extracellular (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	TAAATGCATTTGTCTATAGAG	0.423			NA											14	129					0	0	0.00245	0	0
SLC15A1	6564	broad.mit.edu	37	13	99378453	99378453	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:99378453G>T	uc001vno.2	-	4	246	c.169C>A	c.(169-171)CAT>AAT	p.H57N	SLC15A1_uc001vnp.1_Missense_Mutation_p.H25N	NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	57	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	ACAAACGTATGGTAGATGGCG	0.498			NA											9	41					0.000274275	0.000324617	0.004482	1	0
GPR183	1880	broad.mit.edu	37	13	99947695	99947696	+	Missense_Mutation	DNP	TT	TT	GA			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	TT	TT	-	-	TT	TT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:99947695_99947696TT>GA	uc001vog.2	-	2	878_879	c.704_705AA>TC	c.(703-705)AAA>ATC	p.K235I	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron	NM_004951	NP_004942	P32249	GP183_HUMAN	EBV-induced G protein-coupled receptor 2	235	Cytoplasmic (Potential).				humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0						TTACACCAGATTTCTCAGTGAG	0.351			NA											12	124					0	0	0.004672	0	0
NALCN	259232	broad.mit.edu	37	13	101756709	101756709	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:101756709T>A	uc001vox.1	-	25	3015	c.2826A>T	c.(2824-2826)TTA>TTT	p.L942F		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	942	Helical; Name=S2 of repeat III; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GAGTGAAAAATAAGCCATCTG	0.363			NA											9	66					0	0	0.006214	0	0
NALCN	259232	broad.mit.edu	37	13	101756712	101756712	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr13:101756712G>A	uc001vox.1	-	25	3012	c.2823C>T	c.(2821-2823)GGC>GGT	p.G941G		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	941	Helical; Name=S2 of repeat III; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAAAAATAAGCCATCTGCCA	0.368			NA											8	66					0	0	0.006214	0	0
OR4K5	79317	broad.mit.edu	37	14	20389008	20389008	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:20389008G>T	uc010tkw.1	+	1	243	c.243G>T	c.(241-243)ATG>ATT	p.M81I		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCCCTAAAATGATTGCAGATT	0.438			NA											33	362					2.80507e-11	4.28786e-11	0.002445	1	0
RNASE2	6036	broad.mit.edu	37	14	21424014	21424014	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:21424014A>T	uc010aif.2	+	2	153	c.84A>T	c.(82-84)AAA>AAT	p.K28N	RNASE2_uc001vyl.1_Missense_Mutation_p.K28N	NM_002934	NP_002925	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver,	28					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)		TCCATGTCAAACCTCCACAGT	0.453			NA											5	56					0	0	0.000602	0	0
MYH6	4624	broad.mit.edu	37	14	23876236	23876236	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:23876236C>A	uc001wjv.2	-	3	264	c.197G>T	c.(196-198)GGG>GTG	p.G66V	MYH6_uc010akp.1_Missense_Mutation_p.G66V	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	66	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ACTCACCTTCCCATTCTCGGT	0.572			NA											21	447					3.28513e-13	5.16234e-13	0.003954	1	0
MYH7	4625	broad.mit.edu	37	14	23894495	23894495	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:23894495G>T	uc001wjx.2	-	21	2525	c.2419C>A	c.(2419-2421)CGT>AGT	p.R807S		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	807	IQ.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCTCACCTACGTTCCAGCAGC	0.552			NA											11	36					0.00010058	0.000121606	0.001368	1	0
MYH7	4625	broad.mit.edu	37	14	23898510	23898510	+	Silent	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:23898510C>G	uc001wjx.2	-	13	1291	c.1185G>C	c.(1183-1185)CTG>CTC	p.L395L		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	395	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCCCCTTGAGCAGGTCGGCTG	0.517			NA											20	71					0	0	0.008871	0	0
AKAP6	9472	broad.mit.edu	37	14	33293463	33293463	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:33293463C>A	uc001wrq.2	+	13	6614	c.6444C>A	c.(6442-6444)GAC>GAA	p.D2148E		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2148					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GCTTAGATGACAAGGAAGATA	0.463	Melanoma(49;821 1200 7288 13647 42351)		NA											4	43					0.00909568	0.00994674	0.009096	1	0
PELI2	57161	broad.mit.edu	37	14	56763705	56763705	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:56763705C>T	uc001xch.2	+	6	1370	c.1084C>T	c.(1084-1086)CCA>TCA	p.P362S		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	362					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						CGCAGGACCGCCAACTCATGC	0.557			NA											9	138					0	0	0.006214	0	0
KIAA0586	9786	broad.mit.edu	37	14	58934504	58934504	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:58934504G>A	uc001xdv.3	+	15	2351	c.2078G>A	c.(2077-2079)AGC>AAC	p.S693N	KIAA0586_uc010trr.1_Missense_Mutation_p.S810N|KIAA0586_uc001xdt.3_Missense_Mutation_p.S725N|KIAA0586_uc001xdu.3_Missense_Mutation_p.S754N|KIAA0586_uc010trs.1_Missense_Mutation_p.S684N|KIAA0586_uc010trt.1_Missense_Mutation_p.S629N|KIAA0586_uc010tru.1_Missense_Mutation_p.S629N	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	693										ovary(1)	1						GTGATTGTCAGCAAGCCACAC	0.393			NA											32	203					0	0	0.005524	0	0
DAAM1	23002	broad.mit.edu	37	14	59793303	59793303	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:59793303A>T	uc001xdz.1	+	11	1375	c.1250A>T	c.(1249-1251)GAC>GTC	p.D417V	DAAM1_uc001xea.1_Missense_Mutation_p.D417V|DAAM1_uc001xeb.1_Missense_Mutation_p.D417V	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	417	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		ATCCAGAATGACAAAGGACAG	0.373			NA											12	110					0	0	0.001855	0	0
HSPA2	3306	broad.mit.edu	37	14	65008300	65008300	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:65008300G>A	uc001xhj.2	+	2	809	c.733G>A	c.(733-735)GCG>ACG	p.A245T	HSPA2_uc001xhk.3_Missense_Mutation_p.A245T	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	245					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GAGCCACCTGGCGGAGGAGTT	0.652	Pancreas(136;1211 1835 24894 31984 38227)		NA											4	61					0	0	0.000602	0	0
MAP3K9	4293	broad.mit.edu	37	14	71209068	71209068	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:71209068C>A	uc001xmm.2	-	6	1567	c.1567G>T	c.(1567-1569)GAT>TAT	p.D523Y	MAP3K9_uc010ttk.1_Missense_Mutation_p.D260Y|MAP3K9_uc001xmk.2_Missense_Mutation_p.D217Y|MAP3K9_uc001xml.2_Missense_Mutation_p.D523Y	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	523				KLKDGNRISLPSDFQHKFTVQASPT -> AQPVLPFPHGHS RCPGGTGSSWGGQ (in Ref. 4).	activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GGCCACTGACCAGAAGGGAGG	0.607	GBM(114;411 1587 13539 28235 50070)		NA											8	115					1.12685e-05	1.47015e-05	0.004482	1	0
LTBP2	4053	broad.mit.edu	37	14	74967652	74967652	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:74967652G>T	uc001xqa.2	-	36	5788	c.5401C>A	c.(5401-5403)CGC>AGC	p.R1801S		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1801	EGF-like 20; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CAGTGGCAGCGGTAGGAGCCC	0.567			NA											9	39					7.48243e-07	1.02883e-06	0.006214	1	0
YLPM1	56252	broad.mit.edu	37	14	75264581	75264581	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:75264581G>A	uc001xqj.3	+	5	2705	c.2581G>A	c.(2581-2583)GGA>AGA	p.G861R	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	666					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ACCTCTTTCAGGAAACAAAGA	0.453			NA											8	72					0	0	0.00308	0	0
C14orf145	145508	broad.mit.edu	37	14	81244254	81244254	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:81244254T>A	uc001xux.2	-	15	2519	c.2348A>T	c.(2347-2349)CAA>CTA	p.Q783L	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	783	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		CTTCAAACATTGATATTTTAG	0.303			NA											5	86					0	0	0.000602	0	0
YY1	7528	broad.mit.edu	37	14	100743846	100743846	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:100743846G>T	uc001ygy.1	+	5	1634	c.1154G>T	c.(1153-1155)TGC>TTC	p.C385F	uc001ygz.1_5'Flank	NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	385	C2H2-type 4.|Involved in masking transactivation domain.	Zinc 4.			cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				CCCTATGTGTGCCCCTTCGAT	0.463			NA											7	68					2.7689e-08	3.98295e-08	0.001984	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102496195	102496195	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:102496195G>T	uc001yks.2	+	50	9846	c.9682G>T	c.(9682-9684)GAG>TAG	p.E3228*		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3228	Potential.|Stalk (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AAAGAGCCAAGAGCTGGAGGT	0.463			NA											12	80					0.00136819	0.00156008	0.001368	1	0
TDRD9	122402	broad.mit.edu	37	14	104462107	104462107	+	Silent	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:104462107T>A	uc001yom.3	+	12	1371	c.1341T>A	c.(1339-1341)ATT>ATA	p.I447I	TDRD9_uc001yon.3_Silent_p.I185I	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	447	Helicase C-terminal.				cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CCACCAATATTGCAGAGAGTT	0.353			NA											5	27					0	0	0.001168	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411915	105411915	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr14:105411915C>A	uc010axc.1	-	7	9993	c.9873G>T	c.(9871-9873)GAG>GAT	p.E3291D	AHNAK2_uc001ypx.2_Missense_Mutation_p.E3191D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3291						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACAGGTCCCCCTCCAGCCGTG	0.612			NA											8	208					3.09899e-07	4.31397e-07	0.004482	1	0
GABRG3	2567	broad.mit.edu	37	15	27725868	27725868	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:27725868G>T	uc001zbg.1	+	6	813	c.647G>T	c.(646-648)TGG>TTG	p.W216L	GABRG3_uc001zbf.2_Missense_Mutation_p.W216L	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	216	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CAGAAATCATGGCGGCTTTAT	0.418	NSCLC(114;800 1656 7410 37729 45293)		NA											3	22					0.00909568	0.00994674	0.009096	1	0
RYR3	6263	broad.mit.edu	37	15	33895447	33895447	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:33895447G>T	uc001zhi.2	+	18	2116	c.2046G>T	c.(2044-2046)GTG>GTT	p.V682V	RYR3_uc010bar.2_Silent_p.V682V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	682	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATCTGCGGGTGGGCTGGGCCT	0.577			NA											16	181					5.01169e-05	6.20654e-05	0.00499	1	0
RYR3	6263	broad.mit.edu	37	15	33962753	33962753	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:33962753C>T	uc001zhi.2	+	38	5926	c.5856C>T	c.(5854-5856)TGC>TGT	p.C1952C	RYR3_uc010bar.2_Silent_p.C1952C	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1952	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGAGAGATGCCCCAGTAAGT	0.438			NA											11	57					0	0	0.008291	0	0
UBR1	197131	broad.mit.edu	37	15	43281045	43281045	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:43281045G>A	uc001zqq.2	-	35	4035	c.3969C>T	c.(3967-3969)AGC>AGT	p.S1323S		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1323					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AAGCGCAGGTGCTCCAGGTCA	0.403			NA											6	163					0	0	0.001168	0	0
SLC28A2	9153	broad.mit.edu	37	15	45564558	45564558	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:45564558G>C	uc001zva.2	+	16	1779	c.1714G>C	c.(1714-1716)GCC>CCC	p.A572P		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	572	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		CTTCACAGGGGCCTGTGTATC	0.478	NSCLC(92;493 1501 26361 28917 47116)		NA											10	57					0	0	0.000978	0	0
HSP90AB4P	664618	broad.mit.edu	37	15	58985220	58985220	+	Silent	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:58985220C>G	uc002afh.1	-	1	105	c.105G>C	c.(103-105)CTG>CTC	p.L35L	ADAM10_uc002afd.1_Intron|ADAM10_uc010bgc.1_Intron|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron|ADAM10_uc002afg.2_Intron	NR_002927				RecName: Full=Putative heat shock protein HSP 90-beta 4;												0						AAGGGTCTGTCAGGCTCTCAT	0.448			NA											8	28					0	0	0.004482	0	0
DIS3L	115752	broad.mit.edu	37	15	66610849	66610849	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:66610849G>C	uc010ujm.1	+	8	1072	c.1057G>C	c.(1057-1059)GAA>CAA	p.E353Q	DIS3L_uc010ujl.1_Intron|DIS3L_uc002app.2_Missense_Mutation_p.E270Q|DIS3L_uc002apq.2_Missense_Mutation_p.E353Q|DIS3L_uc010bho.2_Missense_Mutation_p.E219Q	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	353					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						TCCGTCCAAAGAAGAGGTCCA	0.433			NA											10	87					0	0	0.008291	0	0
LRRC49	54839	broad.mit.edu	37	15	71329524	71329524	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:71329524G>T	uc002asw.2	+	15	1957	c.1710G>T	c.(1708-1710)AAG>AAT	p.K570N	LRRC49_uc002asu.2_Missense_Mutation_p.K560N|LRRC49_uc002asx.2_Missense_Mutation_p.K526N|LRRC49_uc010ukf.1_Missense_Mutation_p.K575N|LRRC49_uc002asy.2_Missense_Mutation_p.K276N|LRRC49_uc002asz.2_Missense_Mutation_p.K542N	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	570						cytoplasm|microtubule				ovary(1)	1						ACAGGAAAAAGCAATTTCGGT	0.318			NA											7	114					0.000157383	0.000188658	0.00308	1	0
ACAN	176	broad.mit.edu	37	15	89382144	89382144	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:89382144C>T	uc010upo.1	+	3	695	c.321C>T	c.(319-321)CCC>CCT	p.P107P	ACAN_uc002bmx.2_Silent_p.P107P|ACAN_uc010upp.1_Silent_p.P107P|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	107					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCTCACTGCCCAACTACCCGG	0.617			NA											7	94					0	0	0.00308	0	0
TTC23	64927	broad.mit.edu	37	15	99678233	99678233	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr15:99678233G>A	uc002bur.2	-	13	1857	c.1326C>T	c.(1324-1326)CCC>CCT	p.P442P	TTC23_uc002bus.2_Silent_p.P442P|TTC23_uc002but.2_Silent_p.P442P|TTC23_uc002buu.2_Silent_p.P442P|TTC23_uc002buv.2_Silent_p.P442P|TTC23_uc002bux.2_Silent_p.P442P|TTC23_uc002buw.2_Silent_p.P442P|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Silent_p.P442P|TTC23_uc010bor.2_Silent_p.P442P	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	442							binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			CTGTTGTGCCGGGCCGGGCCT	0.587			NA											3	41					0	0	0.000602	0	0
BAIAP3	8938	broad.mit.edu	37	16	1391159	1391159	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:1391159C>T	uc002clk.1	+	7	603	c.603C>T	c.(601-603)GTC>GTT	p.V201V	BAIAP3_uc002clj.2_Silent_p.V183V|BAIAP3_uc010uuz.1_Silent_p.V166V|BAIAP3_uc010uva.1_Silent_p.V138V|BAIAP3_uc010uvb.1_Silent_p.V218V|BAIAP3_uc010uvc.1_Silent_p.V166V	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	201	C2 1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				AAGTCTCTGTCATGCGTGCCA	0.672			NA											3	46					0	0	0.004672	0	0
A2BP1	54715	broad.mit.edu	37	16	7726787	7726787	+	Silent	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:7726787T>C	uc002cys.2	+	14	1930	c.942T>C	c.(940-942)GCT>GCC	p.A314A	A2BP1_uc002cyt.2_Silent_p.A287A|A2BP1_uc010uxz.1_Silent_p.A357A|A2BP1_uc010uya.1_Silent_p.A271A|A2BP1_uc010uyb.1_Silent_p.A314A|A2BP1_uc002cyw.2_Silent_p.A335A|A2BP1_uc002cyy.2_Silent_p.A335A|A2BP1_uc002cyx.2_Silent_p.A335A|A2BP1_uc010uyc.1_Silent_p.A308A	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	314					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		GTGGTTATGCTGCATACCGCT	0.517			NA											4	75					0	0	0.000602	0	0
C16orf62	57020	broad.mit.edu	37	16	19656206	19656206	+	Splice_Site	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:19656206A>T	uc002dgn.1	+	23	1878	c.1866_splice	c.e23-2	p.N622_splice	C16orf62_uc002dgo.1_Splice_Site_p.N555_splice|C16orf62_uc002dgp.1_Splice_Site_p.N371_splice	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020							integral to membrane				ovary(1)	1						TATTGATTTTAGTGCACTCAC	0.303			NA											5	86					0	0	0.001168	0	0
RBBP6	5930	broad.mit.edu	37	16	24580932	24580932	+	Nonsense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:24580932T>A	uc002dmh.2	+	17	3961	c.2921T>A	c.(2920-2922)TTG>TAG	p.L974*	RBBP6_uc010vcb.1_Nonsense_Mutation_p.L841*|RBBP6_uc002dmi.2_Nonsense_Mutation_p.L940*|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Nonsense_Mutation_p.L807*	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	974					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		ACAGACTCATTGTTTGTTCTC	0.388			NA											16	81					0	0	0.004007	0	0
FAM57B	83723	broad.mit.edu	37	16	30038006	30038006	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:30038006C>T	uc002dvt.2	-	3	706	c.368G>A	c.(367-369)CGT>CAT	p.R123H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|FAM57B_uc002dvu.2_Missense_Mutation_p.R73H	NM_031478	NP_113666	Q71RH2	FA57B_HUMAN	hypothetical protein LOC83723	123	TLC.					endoplasmic reticulum|integral to membrane					0						CAGGTAGCCACGCGCTATGGC	0.652			NA											5	26					0	0	0.001168	0	0
ZNF768	79724	broad.mit.edu	37	16	30536017	30536017	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:30536017C>A	uc002dyk.3	-	2	1620	c.1444G>T	c.(1444-1446)GAG>TAG	p.E482*	ZNF768_uc010vex.1_Nonsense_Mutation_p.E451*|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Nonsense_Mutation_p.E451*	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	482					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						TAGGGCCGCTCGCCCGTGTGG	0.677			NA											5	26					0.000602214	0.000699466	0.000602	1	0
HSD3B7	80270	broad.mit.edu	37	16	30998216	30998216	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:30998216G>T	uc002eaf.2	+	6	693	c.587G>T	c.(586-588)GGT>GTT	p.G196V	HSD3B7_uc010cac.2_Intron|HSD3B7_uc002eag.2_Intron|HSD3B7_uc002eah.2_Missense_Mutation_p.G196V	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	196					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						GGCATCTACGGTGAAGGCCAC	0.672			NA											16	70					1.67942e-08	2.4345e-08	0.006122	1	0
NLRC5	84166	broad.mit.edu	37	16	57054740	57054740	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:57054740C>T	uc002ekk.1	+	3	341	c.116C>T	c.(115-117)ACG>ATG	p.T39M	NLRC5_uc010ccq.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	39					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CTCCCCAACACGGACCTGGAT	0.547			NA											4	57					0	0	0.009096	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064459	78064459	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:78064459C>A	uc002ffh.3	+	3	396	c.315C>A	c.(313-315)CCC>CCA	p.P105P		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	105	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						TGGTTATCCCCAGGAACTCCG	0.473			NA											6	63					2.7689e-08	3.98295e-08	0.001984	1	0
CDH13	1012	broad.mit.edu	37	16	83378559	83378559	+	Silent	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:83378559G>C	uc002fgx.2	+	6	849	c.729G>C	c.(727-729)CCG>CCC	p.P243P	CDH13_uc010vns.1_Silent_p.P290P|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Silent_p.P204P	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	243	Cadherin 1.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		ACAACCGACCGATCTTTCGGG	0.507			NA											13	67					0	0	0.001855	0	0
TAF1C	9013	broad.mit.edu	37	16	84212613	84212613	+	Silent	SNP	G	G	T	rs138100695		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:84212613G>T	uc002fhn.2	-	14	2772	c.2544C>A	c.(2542-2544)TCC>TCA	p.S848S	TAF1C_uc002fhm.2_Silent_p.S754S|TAF1C_uc010vnx.1_Silent_p.S822S|TAF1C_uc010vny.1_Silent_p.S439S|TAF1C_uc010vnz.1_Silent_p.S516S|TAF1C_uc002fho.2_Silent_p.S371S|TAF1C_uc010voa.1_Silent_p.S516S|TAF1C_uc002fhp.1_RNA	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	848					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						TGTGCTGCTGGGAGCGAGTGG	0.652			NA											11	71					1.49906e-05	1.92884e-05	0.00245	1	0
USP10	9100	broad.mit.edu	37	16	84779061	84779061	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr16:84779061A>G	uc002fii.2	+	4	1116	c.974A>G	c.(973-975)GAC>GGC	p.D325G	USP10_uc010voe.1_Missense_Mutation_p.D329G|USP10_uc010vof.1_Intron|USP10_uc002fij.2_5'UTR	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	325					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						CCTCCTGCTGACGGCACGGGC	0.612			NA											3	19					0	0	0.004672	0	0
WSCD1	23302	broad.mit.edu	37	17	6021461	6021461	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:6021461G>C	uc010cli.2	+	8	1707	c.1328G>C	c.(1327-1329)TGT>TCT	p.C443S	WSCD1_uc002gcn.2_Missense_Mutation_p.C443S|WSCD1_uc002gco.2_Missense_Mutation_p.C443S|WSCD1_uc010clj.2_Missense_Mutation_p.C134S	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	443						integral to membrane	sulfotransferase activity				0						AACAGAAAATGTGCCGGGCAC	0.542			NA											13	24					0	0	0.004007	0	0
MYH8	4626	broad.mit.edu	37	17	10323440	10323440	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:10323440A>C	uc002gmm.2	-	3	200	c.105T>G	c.(103-105)GAT>GAG	p.D35E	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	35	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATGTTTTAGCATCAAACGGCT	0.483			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				61	200					0	0	0.00361	0	0
RICH2	9912	broad.mit.edu	37	17	12883520	12883520	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:12883520G>T	uc002gnr.3	+	19	2236	c.1909G>T	c.(1909-1911)GCA>TCA	p.A637S	RICH2_uc010vvk.1_Missense_Mutation_p.A637S|RICH2_uc010vvl.1_Missense_Mutation_p.A631S|RICH2_uc002gns.3_Missense_Mutation_p.A431S|RICH2_uc010vvm.1_Missense_Mutation_p.A631S|RICH2_uc010vvn.1_Intron	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	637					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CCAGCCGCCTGCAGACCAGAG	0.652			NA											5	25					8.12818e-05	9.89135e-05	0.001984	1	0
NOS2	4843	broad.mit.edu	37	17	26110042	26110042	+	Silent	SNP	G	G	A	rs139747007	byFrequency	TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:26110042G>A	uc002gzu.2	-	6	822	c.558C>T	c.(556-558)CTC>CTT	p.L186L	NOS2_uc010crh.1_Silent_p.L186L|NOS2_uc010wab.1_Silent_p.L186L	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	186					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TGGCGAAGATGAGCTCATCTC	0.552			NA											8	61					0	0	0.00308	0	0
TMEM132E	124842	broad.mit.edu	37	17	32961968	32961968	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:32961968C>T	uc002hif.2	+	8	1897	c.1569C>T	c.(1567-1569)GTC>GTT	p.V523V		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	523	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		ACCAGGTGGTCACCATGTTAG	0.617			NA											3	51					0	0	0.009096	0	0
TMEM132E	124842	broad.mit.edu	37	17	32961989	32961989	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:32961989G>A	uc002hif.2	+	8	1918	c.1590G>A	c.(1588-1590)TGG>TGA	p.W530*		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	530	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GCCCGGACTGGCTGGTGGAGG	0.627			NA											4	40					0	0	0.009096	0	0
AP2B1	163	broad.mit.edu	37	17	33935316	33935316	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:33935316G>T	uc002hjr.2	+	5	624	c.435G>T	c.(433-435)GTG>GTT	p.V145V	AP2B1_uc002hjq.2_Silent_p.V145V|AP2B1_uc010wci.1_Silent_p.V107V|AP2B1_uc002hjs.2_Silent_p.V88V|AP2B1_uc002hjt.2_Silent_p.V145V|AP2B1_uc010ctv.2_Silent_p.V145V	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	145					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CAGTCTGCGTGGCAAAACTCC	0.458			NA											31	103					1.30988e-24	2.28212e-24	0.002096	1	0
ADAM11	4185	broad.mit.edu	37	17	42853507	42853507	+	Missense_Mutation	SNP	G	G	T	rs138490145		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:42853507G>T	uc002ihh.2	+	18	1498	c.1498G>T	c.(1498-1500)GGT>TGT	p.G500C	ADAM11_uc010wjd.1_Missense_Mutation_p.G300C|ADAM11_uc002ihi.2_5'Flank	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	500	Extracellular (Potential).|Disintegrin.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				CGAACCACGGGGTGTGTCCTG	0.687			NA											8	103					2.52707e-12	3.91626e-12	0.006214	1	0
SPAG9	9043	broad.mit.edu	37	17	49156969	49156969	+	Nonsense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:49156969T>A	uc002itc.2	-	2	609	c.400A>T	c.(400-402)AAA>TAA	p.K134*	SPAG9_uc002itb.2_Nonsense_Mutation_p.K134*|SPAG9_uc002itd.2_Nonsense_Mutation_p.K134*|SPAG9_uc002itf.2_5'UTR	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	134	Potential.				positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TTTTTCGCTTTCAGCTCAAGT	0.299			NA											31	144					0	0	0.002445	0	0
ANKFN1	162282	broad.mit.edu	37	17	54431318	54431318	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:54431318G>T	uc002iun.1	+	5	556	c.521G>T	c.(520-522)GGC>GTC	p.G174V		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	174	ANK 2.									large_intestine(1)|ovary(1)	2						AACAGCGAGGGCTTGACACCC	0.502			NA											13	48					7.05477e-17	1.15723e-16	0.00499	1	0
COIL	8161	broad.mit.edu	37	17	55038196	55038196	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:55038196T>C	uc002iuu.2	-	1	216	c.185A>G	c.(184-186)GAG>GGG	p.E62G		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	62						Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					GAGCCCCCCCTCCAGGTAGAG	0.672			NA											4	8					0	0	0.009096	0	0
GH1	2688	broad.mit.edu	37	17	61994708	61994708	+	Missense_Mutation	SNP	G	G	C	rs148474991		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:61994708G>C	uc002jdj.2	-	5	677	c.615C>G	c.(613-615)ATC>ATG	p.I205M	GH1_uc002jdi.2_Missense_Mutation_p.I190M|GH1_uc002jdk.2_Missense_Mutation_p.I165M|GH1_uc002jdl.2_Missense_Mutation_p.I110M|GH1_uc002jdm.2_3'UTR|GH1_uc002jdn.2_Missense_Mutation_p.S159W	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	205			I -> M (in short stature; idiopathic autosomal).		glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GGCACTGCACGATGCGCAGGA	0.592			NA											19	49					0	0	0.008871	0	0
SDK2	54549	broad.mit.edu	37	17	71346482	71346482	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:71346482T>A	uc010dfm.2	-	43	5932	c.5932A>T	c.(5932-5934)AGC>TGC	p.S1978C	SDK2_uc002jjt.3_Missense_Mutation_p.S1118C	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1978	Cytoplasmic (Potential).				cell adhesion	integral to membrane				ovary(2)	2						ATCATCTCGCTGTGGCCTAGG	0.567			NA											13	18					0	0	0.00245	0	0
DNAI2	64446	broad.mit.edu	37	17	72301559	72301559	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:72301559G>T	uc002jkf.2	+	9	1288	c.1189G>T	c.(1189-1191)GAA>TAA	p.E397*	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_3'UTR|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	397	WD 4.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AGACAGCCGGGAATCGTCCAT	0.612			NA							Kartagener_syndrome				4	28					0.000602214	0.000699466	0.000602	1	0
TBC1D16	125058	broad.mit.edu	37	17	77926534	77926534	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:77926534C>A	uc002jxj.2	-	4	979	c.863G>T	c.(862-864)CGG>CTG	p.R288L	TBC1D16_uc002jxh.2_5'Flank|TBC1D16_uc002jxi.2_5'Flank|TBC1D16_uc002jxk.1_5'Flank	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	288						intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GGCGCACACCCGCTGCGGCTC	0.682	Ovarian(14;397 562 4850 31922 49378)		NA											6	37					8.12818e-05	9.89135e-05	0.001984	1	0
FASN	2194	broad.mit.edu	37	17	80045689	80045689	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:80045689G>A	uc002kdu.2	-	19	3032	c.2915C>T	c.(2914-2916)CCG>CTG	p.P972L	FASN_uc002kdw.1_Missense_Mutation_p.P188L	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	972					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGGGCTTTCCGGGTGGTCGAA	0.652	Colon(59;314 1043 11189 28578 32273)		NA											9	31					0	0	0.008291	0	0
EPB41L3	23136	broad.mit.edu	37	18	5415909	5415909	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr18:5415909G>A	uc002kmt.1	-	13	2061	c.1975C>T	c.(1975-1977)CCT>TCT	p.P659S	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	659	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						AGAGCCAGAGGGAAGGAGAGA	0.572			NA											19	51					0	0	0.006122	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851954	14851954	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr18:14851954T>G	uc010dlo.2	+	36	3834	c.3654T>G	c.(3652-3654)GAT>GAG	p.D1218E	ANKRD30B_uc010xal.1_Missense_Mutation_p.D360E	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1303										ovary(1)|skin(1)	2						TGAATGTTGATGTGAGTAATA	0.368			NA											5	18					0	0	0.001984	0	0
ZNF521	25925	broad.mit.edu	37	18	22805060	22805060	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr18:22805060G>T	uc002kvk.2	-	4	3069	c.2822C>A	c.(2821-2823)TCC>TAC	p.S941Y	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S941Y|ZNF521_uc002kvl.2_Missense_Mutation_p.S721Y	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	941	C2H2-type 22.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GCCATTTTCGGAGAAGAAGGT	0.488			NA	T	PAX5	ALL								23	67					2.41591e-17	3.97456e-17	0.004656	1	0
CDH2	1000	broad.mit.edu	37	18	25565006	25565006	+	Missense_Mutation	SNP	C	C	A	rs151110746		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr18:25565006C>A	uc002kwg.2	-	13	2626	c.2167G>T	c.(2167-2169)GGT>TGT	p.G723C	CDH2_uc010xbn.1_Missense_Mutation_p.G692C	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	723	Extracellular (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						ATGATGGCACCGGTGCCAAGC	0.483			NA											10	28					0.00621372	0.006862	0.006214	1	0
KIAA1012	22878	broad.mit.edu	37	18	29437775	29437775	+	Silent	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr18:29437775G>C	uc002kxc.3	-	20	3280	c.2916C>G	c.(2914-2916)CCC>CCG	p.P972P	KIAA1012_uc002kxb.3_Silent_p.P918P|KIAA1012_uc002kxd.3_Intron	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	972					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						CAGAAGCTGAGGGACTTAGTG	0.423			NA											58	171					0	0	0.00361	0	0
ZNF532	55205	broad.mit.edu	37	18	56620993	56620993	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr18:56620993G>C	uc002lho.2	+	8	3659	c.3112G>C	c.(3112-3114)GAT>CAT	p.D1038H	ZNF532_uc002lhp.2_Missense_Mutation_p.D1036H|ZNF532_uc010xeg.1_Missense_Mutation_p.D1036H|ZNF532_uc002lhr.2_Missense_Mutation_p.D1036H|ZNF532_uc002lhs.2_Missense_Mutation_p.D1036H|ZNF532_uc010xeh.1_Missense_Mutation_p.D130H	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1038	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CATGCAGAGAGATGTGTACAT	0.408			NA											7	128					0	0	0.00308	0	0
ZNF560	147741	broad.mit.edu	37	19	9577253	9577253	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:9577253G>T	uc002mlp.1	-	10	2580	c.2370C>A	c.(2368-2370)CAC>CAA	p.H790Q	ZNF560_uc010dwr.1_Missense_Mutation_p.H684Q	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	790	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						CTTCTCTCTAGTGTGTTTTCA	0.398			NA											16	60					1.33834e-09	1.99683e-09	0.007413	1	0
CC2D1A	54862	broad.mit.edu	37	19	14040397	14040397	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:14040397G>C	uc002mxo.2	+	26	2933	c.2634G>C	c.(2632-2634)CAG>CAC	p.Q878H	CC2D1A_uc002mxp.2_Missense_Mutation_p.Q877H|CC2D1A_uc010dzh.2_Missense_Mutation_p.Q447H	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	878					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AAGTGGCCCAGCAGTACCAGG	0.657			NA											4	11					0	0	0.000602	0	0
OR7C2	26658	broad.mit.edu	37	19	15052637	15052637	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:15052637T>A	uc010xoc.1	+	1	337	c.337T>A	c.(337-339)TTG>ATG	p.L113M		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					CCTGGACAATTTGCTCCTGAC	0.483			NA											13	47					0	0	0.001855	0	0
OR10H2	26538	broad.mit.edu	37	19	15838973	15838973	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:15838973G>T	uc002nbm.2	+	1	140	c.120G>T	c.(118-120)CTG>CTT	p.L40L		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TCACGCTGCTGGGCAACCTGC	0.582			NA											6	120					0.00198382	0.00223928	0.001984	1	0
OR10H2	26538	broad.mit.edu	37	19	15839525	15839525	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:15839525C>T	uc002nbm.2	+	1	692	c.672C>T	c.(670-672)GCC>GCT	p.A224A		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TCATCGTGGCCGACATCTTGA	0.532			NA											5	90					0	0	0.000602	0	0
ZNF208	7757	broad.mit.edu	37	19	22155045	22155045	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:22155045C>G	uc002nqp.2	-	5	2640	c.2491G>C	c.(2491-2493)GTC>CTC	p.V831L	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTACTAAAGACTGACAACCAG	0.373			NA											4	30					0	0	0.009096	0	0
ZNF257	113835	broad.mit.edu	37	19	22271585	22271585	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:22271585C>T	uc010ecx.2	+	4	1202	c.1033C>T	c.(1033-1035)CAA>TAA	p.Q345*	ZNF257_uc010ecy.2_Nonsense_Mutation_p.Q313*	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	345	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAAACCCTTCCAATGTGAAGA	0.418			NA											8	32					0	0	0.004482	0	0
UQCRFS1	7386	broad.mit.edu	37	19	29698810	29698810	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:29698810G>C	uc002nsd.2	-	2	581	c.470C>G	c.(469-471)TCC>TGC	p.S157C		NM_006003	NP_005994	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske	157					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity				0	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			TGGAATATCGGATAACTTGAT	0.488			NA											5	92					0	0	0.001168	0	0
ZNF536	9745	broad.mit.edu	37	19	30935025	30935025	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:30935025G>T	uc002nsu.1	+	2	694	c.556G>T	c.(556-558)GGC>TGC	p.G186C	ZNF536_uc010edd.1_Missense_Mutation_p.G186C	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGCAACCTGGGCAAGGGGCG	0.667			NA											4	21					0.00024832	0.000296399	0.009096	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769436	31769436	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:31769436C>G	uc002nsy.3	-	2	1328	c.1263G>C	c.(1261-1263)AAG>AAC	p.K421N		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	421					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TGGGCTTCCCCTTTTTCATAG	0.582			NA											13	101					0	0	0.001368	0	0
ZNF585B	92285	broad.mit.edu	37	19	37678134	37678135	+	Missense_Mutation	DNP	CA	CA	GT			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:37678134_37678135CA>GT	uc002ofq.2	-	5	558_559	c.304_305TG>AC	c.(304-306)TGG>ACG	p.W102T	ZNF585B_uc002ofr.1_5'UTR	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTATGGTCCCATAATTTCTCT	0.332	Melanoma(93;882 1454 18863 28917 48427)		NA											13	72					0	0	0.004672	0	0
HKR1	284459	broad.mit.edu	37	19	37854259	37854259	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:37854259G>T	uc002ogb.2	+	6	1831	c.1562G>T	c.(1561-1563)GGG>GTG	p.G521V	HKR1_uc002ofx.2_Missense_Mutation_p.G237V|HKR1_uc002ofy.2_Missense_Mutation_p.G237V|HKR1_uc002oga.2_Missense_Mutation_p.G503V|HKR1_uc010xto.1_Missense_Mutation_p.G503V|HKR1_uc002ogc.2_Missense_Mutation_p.G502V|HKR1_uc010xtp.1_Missense_Mutation_p.G460V|HKR1_uc002ogd.2_Missense_Mutation_p.G460V	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	521					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACACACTCAGGGGAGAAGCCA	0.517			NA											3	35					0.004672	0.00517983	0.004672	1	0
RYR1	6261	broad.mit.edu	37	19	39008033	39008033	+	Silent	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:39008033T>C	uc002oit.2	+	66	9850	c.9720T>C	c.(9718-9720)TGT>TGC	p.C3240C	RYR1_uc002oiu.2_Silent_p.C3240C|RYR1_uc002oiv.1_Silent_p.C160C|RYR1_uc010xuf.1_Silent_p.C160C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3240					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGAGATGTGTCCCGACATCC	0.647			NA											3	40					0	0	0.009096	0	0
PSG8	440533	broad.mit.edu	37	19	43268239	43268239	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:43268239G>T	uc002ouo.2	-	2	357	c.259C>A	c.(259-261)CAA>AAA	p.Q87K	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.Q87K|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.Q87K|PSG8_uc002oum.3_Missense_Mutation_p.Q87K|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.Q87K	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	87	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				ATAATTATTTGACCGTCTACT	0.433			NA											70	282					2.60599e-31	4.59736e-31	0.00361	1	0
GPR4	2828	broad.mit.edu	37	19	46094546	46094546	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:46094546C>A	uc002pcm.2	-	2	1524	c.579G>T	c.(577-579)CCG>CCT	p.P193P	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	193	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		TGAGCGCCCACGGGAAGAGGA	0.642	Esophageal Squamous(117;181 1612 1673 14956 42937)		NA											3	43					0.004672	0.00517983	0.004672	1	0
SPACA4	171169	broad.mit.edu	37	19	49110448	49110448	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:49110448C>A	uc002pjo.2	+	1	449	c.213C>A	c.(211-213)TGC>TGA	p.C71*	FAM83E_uc002pjn.2_Intron	NM_133498	NP_598005	Q8TDM5	SACA4_HUMAN	sperm acrosomal membrane protein 14 precursor	71	UPAR/Ly6 1.				cell adhesion	acrosomal vesicle|anchored to membrane|plasma membrane				central_nervous_system(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		CCACCAGCTGCGGCCTTGAGG	0.652			NA											3	28					6.4e-05	7.85819e-05	0.004672	1	0
RASIP1	54922	broad.mit.edu	37	19	49225186	49225186	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:49225186A>C	uc002pki.2	-	11	2814	c.2617T>G	c.(2617-2619)TAT>GAT	p.Y873D	MAMSTR_uc002pkg.2_5'Flank|RASIP1_uc002pkh.2_Missense_Mutation_p.Y134D	NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	873	Dilute.				signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CCCAGCTGATAGTGGCTGAGC	0.652			NA											8	45					0	0	0.004482	0	0
KLK8	11202	broad.mit.edu	37	19	51499377	51499377	+	Missense_Mutation	SNP	C	C	T	rs56296296	byFrequency	TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:51499377C>T	uc002pur.1	-	6	900	c.721G>A	c.(721-723)GTC>ATC	p.V241I	KLK8_uc002puq.1_Missense_Mutation_p.V286I|KLK8_uc002pus.1_Missense_Mutation_p.V100I|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Missense_Mutation_p.V241I|KLK9_uc002puv.1_RNA	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	241	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		TTGGTATAGACGCCAGGTTTG	0.542			NA											15	178					0	0	0.00499	0	0
ZNF665	79788	broad.mit.edu	37	19	53667774	53667774	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr19:53667774T>A	uc010eqm.1	-	4	2069	c.1969A>T	c.(1969-1971)AAC>TAC	p.N657Y		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	592	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		CCACATTGGTTACATTTGTAA	0.363			NA											12	42					0	0	0.000978	0	0
TPO	7173	broad.mit.edu	37	2	1520666	1520666	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:1520666C>A	uc002qww.2	+	15	2621	c.2530C>A	c.(2530-2532)CTC>ATC	p.L844I	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.L787I|TPO_uc002qwr.2_Missense_Mutation_p.L844I|TPO_uc002qwx.2_Missense_Mutation_p.L787I|TPO_uc010yio.1_Missense_Mutation_p.L671I|TPO_uc010yip.1_Missense_Mutation_p.L800I|TPO_uc002qwy.1_Missense_Mutation_p.L140I|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	844	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CTCCGGGAGGCTCCCTCGGGT	0.602			NA											11	52					3.86212e-05	4.79347e-05	0.008291	1	0
GEN1	348654	broad.mit.edu	37	2	17953925	17953925	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:17953925A>G	uc002rct.2	+	8	900	c.827A>G	c.(826-828)AAT>AGT	p.N276S	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.N276S|GEN1_uc002rcu.2_Missense_Mutation_p.N276S	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	276					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding	p.R275fs*37(2)		breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CATGAACGTAATGGATGCAGA	0.353			NA						Homologous_recombination					5	81					0	0	0.000602	0	0
APOB	338	broad.mit.edu	37	2	21233331	21233331	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:21233331G>C	uc002red.2	-	26	6537	c.6409C>G	c.(6409-6411)CAT>GAT	p.H2137D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2137	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCTTGGCATGTGAAACTTGT	0.338			NA											5	38					0	0	0.000602	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121559	27121559	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:27121559C>G	uc002rhu.3	+	2	350	c.192C>G	c.(190-192)GAC>GAG	p.D64E	DPYSL5_uc002rhv.3_Missense_Mutation_p.D64E	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	64					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGGCATCGACACCAGCACCC	0.572			NA											9	41					0	0	0.004482	0	0
SLC8A1	6546	broad.mit.edu	37	2	40342547	40342547	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:40342547C>A	uc002rrx.2	-	10	2792	c.2768G>T	c.(2767-2769)GGG>GTG	p.G923V	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.G918V|SLC8A1_uc002rrz.2_Missense_Mutation_p.G910V|SLC8A1_uc002rsa.2_Missense_Mutation_p.G887V|SLC8A1_uc002rsd.3_Missense_Mutation_p.G887V	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	923	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CAGCAGCACCCCCACATTGAT	0.562			NA											12	51					9.31168e-06	1.22626e-05	0.001855	1	0
ABCG8	64241	broad.mit.edu	37	2	44079912	44079912	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:44079912C>A	uc002rtq.2	+	6	959	c.869C>A	c.(868-870)ACC>AAC	p.T290N	ABCG8_uc010yoa.1_Missense_Mutation_p.T290N	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	290	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACGTCTGGCACCCCCATCTAC	0.582			NA											7	57					2.0095e-06	2.70342e-06	0.001984	1	0
PREPL	9581	broad.mit.edu	37	2	44566424	44566424	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:44566424C>A	uc002ruf.2	-	6	866	c.831G>T	c.(829-831)GTG>GTT	p.V277V	PREPL_uc002rug.2_Silent_p.V277V|PREPL_uc002ruh.2_Silent_p.V277V|PREPL_uc010fax.2_Silent_p.V277V|PREPL_uc002rui.3_Silent_p.V188V|PREPL_uc002ruj.1_Silent_p.V188V|PREPL_uc002ruk.1_Silent_p.V277V	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	277					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTATCAACCACACTTCAGAAG	0.403			NA											8	72					0.000157383	0.000188658	0.00308	1	0
FSHR	2492	broad.mit.edu	37	2	49195971	49195971	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:49195971A>G	uc002rww.2	-	9	794	c.720T>C	c.(718-720)AAT>AAC	p.N240N	FSHR_uc002rwx.2_Intron|FSHR_uc010fbn.2_Silent_p.N214N	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	240	Extracellular (Potential).|LRR 8.				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GCTTCTTAAGATTTTCTAAGC	0.428			NA							Gonadal_Dysgenesis_46_XX				3	52					0	0	0.009096	0	0
PAPOLG	64895	broad.mit.edu	37	2	60998766	60998766	+	Splice_Site	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:60998766G>T	uc002sai.2	+	7	835	c.604_splice	c.e7+1	p.G202_splice	PAPOLG_uc002saj.2_Splice_Site|PAPOLG_uc002sak.2_Intron	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma						mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			AGCTTAAATGGTAAGCTTCTA	0.353	GBM(183;1497 2932 21839 46797)		NA											19	70					6.33239e-15	1.01499e-14	0.010504	1	0
REL	5966	broad.mit.edu	37	2	61149634	61149634	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:61149634G>C	uc002sam.1	+	11	2048	c.1824G>C	c.(1822-1824)TTG>TTC	p.L608F	REL_uc002san.1_Missense_Mutation_p.L576F	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	608					positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			ATGAGCAATTGAGTGACTCCT	0.333			NA	A		Hodgkin Lymphoma								10	65					0	0	0.008291	0	0
ALMS1	7840	broad.mit.edu	37	2	73717864	73717864	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:73717864A>T	uc002sje.1	+	12	8892	c.8781A>T	c.(8779-8781)CAA>CAT	p.Q2927H	ALMS1_uc002sjf.1_Missense_Mutation_p.Q2883H|ALMS1_uc002sjg.2_Missense_Mutation_p.Q2313H|ALMS1_uc002sjh.1_Missense_Mutation_p.Q2313H	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2925					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TTCTTGAACAACGAGAACTCT	0.453			NA											23	251					0	0	0.002299	0	0
SLC9A4	389015	broad.mit.edu	37	2	103148979	103148979	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:103148979G>T	uc002tbz.3	+	12	2686	c.2229G>T	c.(2227-2229)GTG>GTT	p.V743V		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	743	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						TAAGGAGGGTGGCCTTAAGAC	0.502			NA											11	27					3.86212e-05	4.79347e-05	0.008291	1	0
RANBP2	5903	broad.mit.edu	37	2	109380702	109380702	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:109380702G>T	uc002tem.3	+	20	3833	c.3707G>T	c.(3706-3708)CGA>CTA	p.R1236L		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1236	RanBD1 1.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CTAATGAGACGAGAGCAAGTA	0.383			NA											7	92					2.0095e-06	2.70342e-06	0.001984	1	0
RANBP2	5903	broad.mit.edu	37	2	109382540	109382540	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:109382540G>A	uc002tem.3	+	20	5671	c.5545G>A	c.(5545-5547)GCT>ACT	p.A1849T		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1849					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CTCAGAAAAAGCTTCTAAGTT	0.383			NA											13	215					0	0	0.001368	0	0
UGGT1	56886	broad.mit.edu	37	2	128941255	128941255	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:128941255A>G	uc002tps.2	+	38	4429	c.4251A>G	c.(4249-4251)CTA>CTG	p.L1417L	UGGT1_uc002tpr.2_Silent_p.L1393L	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1417	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TCAGTGCACTATATGTTGTGG	0.433			NA											11	59					0	0	0.001368	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131904333	131904333	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:131904333T>C	uc002tsg.3	+	8	1216	c.656T>C	c.(655-657)TTT>TCT	p.F219S	PLEKHB2_uc002tsh.2_Intron|PLEKHB2_uc002tsj.3_Missense_Mutation_p.F218S|PLEKHB2_uc002tsf.3_Missense_Mutation_p.F227S|PLEKHB2_uc010zao.1_Missense_Mutation_p.F169S|PLEKHB2_uc010zap.1_3'UTR|PLEKHB2_uc010zaq.1_3'UTR|PLEKHB2_uc002tsi.3_Missense_Mutation_p.F260S	NM_001100623	NP_001094093	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B	219						membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.0828)		GGGTCTCTATTTTGGGTCTTC	0.502			NA											33	219					0	0	0.002445	0	0
LOC150776	150776	broad.mit.edu	37	2	132277131	132277131	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:132277131G>T	uc002tsz.3	+	2	588	c.141G>T	c.(139-141)CAG>CAT	p.Q47H	LOC150776_uc002tsy.3_RNA					Homo sapiens cDNA FLJ41352 fis, clone BRAWH2014645.												0						AGCTTAGGCAGTTCACACTCG	0.587			NA											8	33					1.12685e-05	1.47015e-05	0.004482	1	0
THSD7B	80731	broad.mit.edu	37	2	137814464	137814464	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:137814464C>T	uc002tva.1	+	2	521	c.521C>T	c.(520-522)GCG>GTG	p.A174V	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.A64V	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGAACTCGCGCGGTCATAGCT	0.502			NA											50	205					0	0	0.00361	0	0
LRP1B	53353	broad.mit.edu	37	2	141747165	141747165	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:141747165T>A	uc002tvj.1	-	17	3678	c.2706A>T	c.(2704-2706)AGA>AGT	p.R902S	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	902	Extracellular (Potential).|LDL-receptor class A 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACAAAGCCATCTCTTGGGGA	0.413	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			22	108					0	0	0.002299	0	0
NEB	4703	broad.mit.edu	37	2	152472566	152472566	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:152472566C>G	uc010fnx.2	-	72	10701	c.10510G>C	c.(10510-10512)GAT>CAT	p.D3504H		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3504	Nebulin 96.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGAATGGCATCCAGACGCAAG	0.378			NA											3	42					0	0	0.004672	0	0
LY75	4065	broad.mit.edu	37	2	160755507	160755507	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:160755507C>A	uc002ubc.3	-	2	227	c.158G>T	c.(157-159)TGG>TTG	p.W53L	LY75_uc002ubb.3_Missense_Mutation_p.W53L|LY75_uc010fos.2_Missense_Mutation_p.W53L|LY75_uc010fot.1_Missense_Mutation_p.W53L	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	53	Extracellular (Potential).|Ricin B-type lectin.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TGCTACTATCCAGCCATACAC	0.488			NA											32	109					8.16721e-17	1.3358e-16	0.002096	1	0
ITGB6	3694	broad.mit.edu	37	2	160958301	160958301	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:160958301A>G	uc002ubh.2	-	15	2329	c.2313T>C	c.(2311-2313)AAT>AAC	p.N771N	ITGB6_uc002ubg.2_5'Flank|ITGB6_uc010fou.2_Silent_p.N771N|ITGB6_uc010zcq.1_Silent_p.N729N|ITGB6_uc010fov.1_Silent_p.N771N	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	771	Cytoplasmic (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						TATAAGTTACATTTTTAAAAG	0.308			NA											16	80					0	0	0.008871	0	0
SCN3A	6328	broad.mit.edu	37	2	165946747	165946747	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:165946747A>C	uc002ucx.2	-	28	6408	c.5916T>G	c.(5914-5916)AGT>AGG	p.S1972R	SCN3A_uc010zcy.1_Missense_Mutation_p.S455R|SCN3A_uc002ucy.2_Missense_Mutation_p.S1923R|SCN3A_uc002ucz.2_Missense_Mutation_p.S1923R	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1972						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GTTTTGTTACACTATCATAGG	0.358			NA											5	35					0	0	0.001168	0	0
XIRP2	129446	broad.mit.edu	37	2	168102059	168102059	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:168102059C>G	uc002udx.2	+	8	4175	c.4157C>G	c.(4156-4158)TCT>TGT	p.S1386C	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S1211C|XIRP2_uc010fpq.2_Missense_Mutation_p.S1164C|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1211	Xin 24.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GATGTTAGTTCTGTCAGATAC	0.343			NA											28	82					0	0	0.008361	0	0
TTN	7273	broad.mit.edu	37	2	179614245	179614245	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:179614245A>G	uc002unb.2	-	46	13106	c.12882T>C	c.(12880-12882)TTT>TTC	p.F4294F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGGGAGTAAAGGGACCAG	0.393			NA											9	110					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179632810	179632810	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:179632810C>A	uc010zfg.1	-	39	9460	c.9236G>T	c.(9235-9237)TGT>TTT	p.C3079F	TTN_uc010zfh.1_Missense_Mutation_p.C3033F|TTN_uc010zfi.1_Missense_Mutation_p.C3033F|TTN_uc010zfj.1_Missense_Mutation_p.C3033F|TTN_uc002unb.2_Missense_Mutation_p.C3079F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3079							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAACTTCACATTCAAACAT	0.393			NA											12	92					1.02788e-11	1.57984e-11	0.00499	1	0
CCDC141	285025	broad.mit.edu	37	2	179736949	179736949	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:179736949T>C	uc002unf.1	-	3	322	c.265A>G	c.(265-267)AGC>GGC	p.S89G		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	89	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CGAAGGAGGCTAAGTTCTTCC	0.453			NA											8	85					0	0	0.004482	0	0
COL3A1	1281	broad.mit.edu	37	2	189870935	189870935	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:189870935A>T	uc002uqj.1	+	42	3160	c.3043A>T	c.(3043-3045)AAC>TAC	p.N1015Y		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1015	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAATCAGGGAAACCCTGGATC	0.303			NA											12	60					0	0	0.000978	0	0
C2orf66	401027	broad.mit.edu	37	2	197674047	197674047	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:197674047G>T	uc002utv.2	-	1	954	c.65C>A	c.(64-66)CCT>CAT	p.P22H		NM_213608	NP_998773	Q6UXQ4	CB066_HUMAN	hypothetical protein LOC401027 precursor	22						extracellular region					0						TAGCAGGAGAGGTGCTCTGGT	0.507			NA											15	187					2.62699e-14	4.19869e-14	0.003163	1	0
C2orf67	151050	broad.mit.edu	37	2	210887823	210887823	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:210887823A>T	uc002vds.2	-	15	3022	c.2814T>A	c.(2812-2814)GAT>GAA	p.D938E	C2orf67_uc002vdt.2_Missense_Mutation_p.D896E	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	938										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		TTTCAACCTGATCCTTTTTTT	0.448			NA											10	69					0	0	0.006214	0	0
TRIP12	9320	broad.mit.edu	37	2	230724103	230724103	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:230724103G>A	uc002vpw.1	-	3	395	c.286C>T	c.(286-288)CAG>TAG	p.Q96*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.Q138*|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Nonsense_Mutation_p.Q96*	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	96					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TCAGTATGCTGAAGTGCTTTT	0.433			NA											7	224					0	0	0.001984	0	0
COL6A3	1293	broad.mit.edu	37	2	238249699	238249699	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:238249699C>A	uc002vwl.2	-	38	8145	c.7860G>T	c.(7858-7860)ATG>ATT	p.M2620I	COL6A3_uc002vwo.2_Missense_Mutation_p.M2414I|COL6A3_uc010znj.1_Missense_Mutation_p.M2013I|COL6A3_uc002vwj.2_Missense_Mutation_p.M1I	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2620	VWFA 12.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGATGAAAGCCATGTCGATGT	0.527			NA											48	169					1.56793e-16	2.54958e-16	0.00361	1	0
OR6B2	389090	broad.mit.edu	37	2	240969109	240969109	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:240969109G>T	uc002vyr.2	-	2	784	c.738C>A	c.(736-738)ACC>ACA	p.T246T	OR6B2_uc010zoc.1_Silent_p.T246T	NM_001005853	NP_001005853	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CGGTGACCACGGTGAGGTGAG	0.572			NA											4	52					0.00909568	0.00994674	0.009096	1	0
CAPN10	11132	broad.mit.edu	37	2	241535790	241535790	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:241535790G>A	uc002vzk.1	+	8	1517	c.1333G>A	c.(1333-1335)GGC>AGC	p.G445S	CAPN10_uc002vzl.1_Intron|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Missense_Mutation_p.G317S|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	445	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		CCCCGTGGCTGGCACCGCGTG	0.667			NA											6	69					0	0	0.001168	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242741367	242741367	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:242741367C>A	uc002wcj.1	+	3	422	c.291C>A	c.(289-291)CTC>CTA	p.L97L		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	97	Lumenal (Potential).				biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		ACCCCTGGCTCTTCCTGGCGC	0.662			NA											11	47					0.000673444	0.000778973	0.008291	1	0
C20orf54	113278	broad.mit.edu	37	20	744476	744476	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:744476A>T	uc002wed.3	-	3	1078	c.739T>A	c.(739-741)TGC>AGC	p.C247S	C20orf54_uc002wee.2_Missense_Mutation_p.C247S	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	247					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GCCTCCCAGCACCTGGGTTGA	0.617			NA											10	52					0	0	0.008291	0	0
TGM6	343641	broad.mit.edu	37	20	2384386	2384386	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:2384386A>G	uc002wfy.1	+	9	1314	c.1253A>G	c.(1252-1254)AAG>AGG	p.K418R	TGM6_uc010gal.1_Missense_Mutation_p.K418R	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	418					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	TCAAACACGAAGAAGATTGGG	0.582			NA											17	80					0	0	0.00499	0	0
C20orf103	24141	broad.mit.edu	37	20	9496977	9496977	+	Silent	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:9496977G>C	uc002wni.1	+	4	673	c.444G>C	c.(442-444)TCG>TCC	p.S148S	C20orf103_uc010zrc.1_Silent_p.S104S	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	148	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			ACGACTCCTCGGAGAAAACCC	0.572			NA											6	71					0	0	0.001984	0	0
BTBD3	22903	broad.mit.edu	37	20	11898955	11898955	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:11898955G>T	uc002wnz.2	+	1	391	c.32G>T	c.(31-33)TGT>TTT	p.C11F	BTBD3_uc002wny.2_Intron|BTBD3_uc002woa.2_Intron|BTBD3_uc010zrf.1_Intron|BTBD3_uc010zrg.1_5'Flank|BTBD3_uc010zrh.1_5'Flank	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	11										ovary(2)|central_nervous_system(1)	3						AACATGAAATGTCTCACCTTC	0.333			NA											56	246					6.75472e-32	1.19539e-31	0.00361	1	0
TMEM90B	79953	broad.mit.edu	37	20	24565510	24565510	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:24565510A>G	uc002wtw.1	+	3	1132	c.499A>G	c.(499-501)ACA>GCA	p.T167A		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	167	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						CTCAAGCGACACAGAGAGTGA	0.562			NA											19	123					0	0	0.010504	0	0
HCK	3055	broad.mit.edu	37	20	30662469	30662469	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:30662469G>T	uc002wxh.2	+	5	544	c.373G>T	c.(373-375)GAG>TAG	p.E125*	HCK_uc010gdy.2_Nonsense_Mutation_p.E104*|HCK_uc002wxi.2_Nonsense_Mutation_p.E103*	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	125	SH3.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CACCCGGAAGGAGGGCTACAT	0.537			NA											14	102					0.000422831	0.000498337	0.004007	1	0
BPIL3	128859	broad.mit.edu	37	20	31622623	31622623	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:31622623C>G	uc010zuc.1	+	4	357	c.357C>G	c.(355-357)AAC>AAG	p.N119K	BPIL3_uc010zud.1_Missense_Mutation_p.N58K	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	119						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						CAGCCACCAACCGGCTTCTGC	0.577			NA											26	69					0	0	0.00632	0	0
GDF5	8200	broad.mit.edu	37	20	34022074	34022074	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:34022074C>T	uc002xck.1	-	2	1458	c.1139G>A	c.(1138-1140)CGG>CAG	p.R380Q	GDF5_uc010gfc.1_Missense_Mutation_p.R380Q|uc002xcj.2_Missense_Mutation_p.P162L|GDF5_uc010zvc.1_Missense_Mutation_p.R380Q	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	380			R -> Q (in BDA2; reduces activity; impairs processing).		cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TGGGGCCCGCCGTTTTCGCCG	0.582			NA											52	123					0	0	0.00361	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44505598	44505598	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:44505598C>T	uc002xqd.2	+	2	604	c.401C>T	c.(400-402)ACC>ATC	p.T134I	ZSWIM3_uc010zxg.1_Missense_Mutation_p.T128I	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	134							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				CAGCCCACAACCAAAAAAGAC	0.502			NA											8	40					0	0	0.00308	0	0
ZMYND8	23613	broad.mit.edu	37	20	45905216	45905216	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:45905216C>A	uc002xta.1	-	11	1516	c.1262G>T	c.(1261-1263)GGC>GTC	p.G421V	ZMYND8_uc010ghq.1_Missense_Mutation_p.G98V|ZMYND8_uc010ghr.1_Missense_Mutation_p.G396V|ZMYND8_uc002xst.1_Missense_Mutation_p.G396V|ZMYND8_uc002xsu.1_Missense_Mutation_p.G421V|ZMYND8_uc002xsv.1_Missense_Mutation_p.G396V|ZMYND8_uc002xsw.1_Missense_Mutation_p.G173V|ZMYND8_uc002xsx.1_Missense_Mutation_p.G173V|ZMYND8_uc002xsy.1_Missense_Mutation_p.G396V|ZMYND8_uc002xsz.1_Missense_Mutation_p.G358V|ZMYND8_uc010zxy.1_Missense_Mutation_p.G448V|ZMYND8_uc002xtb.1_Missense_Mutation_p.G441V|ZMYND8_uc002xss.2_Missense_Mutation_p.G421V|ZMYND8_uc010zxz.1_Missense_Mutation_p.G416V|ZMYND8_uc002xtc.1_Missense_Mutation_p.G441V|ZMYND8_uc002xtd.1_Missense_Mutation_p.G416V|ZMYND8_uc002xte.1_Missense_Mutation_p.G421V|ZMYND8_uc010zya.1_Missense_Mutation_p.G421V|ZMYND8_uc002xtf.1_Missense_Mutation_p.G441V|ZMYND8_uc002xtg.2_Missense_Mutation_p.G415V|ZMYND8_uc010ghs.1_Missense_Mutation_p.G415V	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	421							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			AATCCGGCGGCCTGTGCCCCC	0.577			NA											9	87					0.000978159	0.00112448	0.000978	1	0
ZMYND8	23613	broad.mit.edu	37	20	45918993	45918993	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:45918993C>A	uc002xta.1	-	7	880	c.626G>T	c.(625-627)TGC>TTC	p.C209F	ZMYND8_uc010ghr.1_Missense_Mutation_p.C184F|ZMYND8_uc002xst.1_Missense_Mutation_p.C184F|ZMYND8_uc002xsu.1_Missense_Mutation_p.C209F|ZMYND8_uc002xsv.1_Missense_Mutation_p.C184F|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.C184F|ZMYND8_uc002xsz.1_Missense_Mutation_p.C146F|ZMYND8_uc010zxy.1_Missense_Mutation_p.C236F|ZMYND8_uc002xtb.1_Missense_Mutation_p.C229F|ZMYND8_uc002xss.2_Missense_Mutation_p.C209F|ZMYND8_uc010zxz.1_Missense_Mutation_p.C204F|ZMYND8_uc002xtc.1_Missense_Mutation_p.C229F|ZMYND8_uc002xtd.1_Missense_Mutation_p.C204F|ZMYND8_uc002xte.1_Missense_Mutation_p.C209F|ZMYND8_uc010zya.1_Missense_Mutation_p.C209F|ZMYND8_uc002xtf.1_Missense_Mutation_p.C229F|ZMYND8_uc002xtg.2_Missense_Mutation_p.C203F|ZMYND8_uc010ghs.1_Missense_Mutation_p.C203F	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	209	Bromo.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GGCTTCTGTGCAGCCATACAT	0.453			NA											12	83					0.00010058	0.000121606	0.001368	1	0
PREX1	57580	broad.mit.edu	37	20	47268039	47268039	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:47268039G>T	uc002xtw.1	-	22	2573	c.2550C>A	c.(2548-2550)CAC>CAA	p.H850Q	PREX1_uc002xtv.1_Missense_Mutation_p.H147Q	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	850					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CGTGTTCCAGGTGCACGTTGT	0.562			NA											22	47					9.86323e-18	1.64192e-17	0.003954	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47592674	47592674	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:47592674T>A	uc002xtx.3	+	14	2048	c.1896T>A	c.(1894-1896)GAT>GAA	p.D632E		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	632					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CTGTTCAGGATGACCCTGAGC	0.512	Esophageal Squamous(176;1738 1974 26285 33069 35354)		NA											5	31					0	0	0.000602	0	0
ZNF831	128611	broad.mit.edu	37	20	57829409	57829409	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:57829409T>A	uc002yan.2	+	5	4645	c.4645T>A	c.(4645-4647)TCT>ACT	p.S1549T		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1549						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GAGACCTTCATCTGGACAAAG	0.498			NA											11	44					0	0	0.008291	0	0
EDN3	1908	broad.mit.edu	37	20	57896227	57896227	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:57896227C>A	uc002yap.2	+	3	890	c.521C>A	c.(520-522)ACC>AAC	p.T174N	EDN3_uc002yao.1_Missense_Mutation_p.T174N|EDN3_uc002yaq.2_Missense_Mutation_p.T174N|EDN3_uc002yar.2_Missense_Mutation_p.T174N|EDN3_uc002yas.2_Missense_Mutation_p.T174N	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	174					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					CACTTTTGCACCCAAACTCTG	0.567			NA											7	121					1.12685e-05	1.47015e-05	0.004482	1	0
C20orf195	79025	broad.mit.edu	37	20	62187726	62187726	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr20:62187726C>A	uc002yfj.2	+	2	802	c.710C>A	c.(709-711)TCG>TAG	p.S237*	C20orf195_uc002yfk.2_Nonsense_Mutation_p.S237*	NM_024059	NP_076964	Q9BVV2	CT195_HUMAN	hypothetical protein LOC79025	237											0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			CCAGCCACATCGGAGCAGTAT	0.652			NA											43	136					8.20599e-20	1.39926e-19	0.002852	1	0
TPTE	7179	broad.mit.edu	37	21	10934071	10934071	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr21:10934071G>T	uc002yip.1	-	16	1274	c.906C>A	c.(904-906)ATC>ATA	p.I302I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.I284I|TPTE_uc002yir.1_Silent_p.I264I|TPTE_uc010gkv.1_Silent_p.I164I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	302	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATCAATCATGATTCTAACGA	0.313			NA											16	291					7.07596e-05	8.66728e-05	0.006122	1	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971137	31971137	+	Silent	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr21:31971137T>A	uc011adc.1	-	1	57	c.57A>T	c.(55-57)GGA>GGT	p.G19G	KRTAP22-1_uc011add.1_5'Flank	NM_181604	NP_853635	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	19						intermediate filament					0						GGCCTTCGTATCCACAGCACC	0.567			NA											9	70					0	0	0.008291	0	0
ITSN1	6453	broad.mit.edu	37	21	35229038	35229038	+	Splice_Site	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr21:35229038A>T	uc002yta.1	+	30	3930	c.3662_splice	c.e30-2	p.W1221_splice	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Splice_Site_p.W1216_splice|ITSN1_uc002ytj.2_Splice_Site_p.W1216_splice|ITSN1_uc010gmm.1_Splice_Site|ITSN1_uc002yti.1_Splice_Site	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						TGTGTTTTCCAGGGTGTTCAG	0.502			NA											18	62					0	0	0.006122	0	0
TTC3	7267	broad.mit.edu	37	21	38537963	38537963	+	Silent	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr21:38537963A>T	uc002yvz.2	+	33	3552	c.3447A>T	c.(3445-3447)GCA>GCT	p.A1149A	TTC3_uc011aee.1_Silent_p.A839A|TTC3_uc002ywa.2_Silent_p.A1149A|TTC3_uc002ywb.2_Silent_p.A1149A|TTC3_uc010gnf.2_Silent_p.A914A|TTC3_uc002ywc.2_Silent_p.A839A|TTC3_uc002ywd.1_Silent_p.A213A	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1149					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TAGAAAAAGCAGGAGGTTTAA	0.408	Ovarian(38;194 1649 35661)		NA											54	305					0	0	0.00361	0	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr21:44524456G>A	uc002zda.1	-	2	185	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTGCAACCGAGAGCACCTGTC	0.358			NA											13	37					0	0	0.00245	0	0
RRP1	8568	broad.mit.edu	37	21	45220427	45220427	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr21:45220427G>T	uc002zds.2	+	10	1014	c.921G>T	c.(919-921)CTG>CTT	p.L307L	RRP1_uc011aez.1_Silent_p.L307L|RRP1_uc010gpk.1_Silent_p.L157L|RRP1_uc010gpl.1_Silent_p.L205L|RRP1_uc010gpm.1_Silent_p.L174L	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	307					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		CTAACAGACTGTTTGAAATGG	0.557			NA											7	44					2.0095e-06	2.70342e-06	0.001984	1	0
PCNT	5116	broad.mit.edu	37	21	47801665	47801665	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr21:47801665G>T	uc002zji.3	+	16	3329	c.3222G>T	c.(3220-3222)CGG>CGT	p.R1074R	PCNT_uc002zjj.2_Silent_p.R956R	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1074	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGACACTTCGGCTTCAGAGTG	0.413			NA											9	242					1.58986e-06	2.16484e-06	0.008291	1	0
PRAME	23532	broad.mit.edu	37	22	22892596	22892596	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr22:22892596C>T	uc002zwf.2	-	4	661	c.505G>A	c.(505-507)GAG>AAG	p.E169K	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.E153K|PRAME_uc010gtr.2_Missense_Mutation_p.E169K|PRAME_uc002zwg.2_Missense_Mutation_p.E169K|PRAME_uc002zwh.2_Missense_Mutation_p.E169K|PRAME_uc002zwi.2_Missense_Mutation_p.E169K|PRAME_uc002zwj.2_Missense_Mutation_p.E169K|PRAME_uc002zwk.2_Missense_Mutation_p.E169K	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	169					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		AAGGGCTGCTCTGCCTCTGTG	0.493	Melanoma(73;1707 1838 15168 27201)		NA											8	89					0	0	0.00308	0	0
SMTN	6525	broad.mit.edu	37	22	31487707	31487707	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr22:31487707T>A	uc003ajl.1	+	11	1724	c.1506T>A	c.(1504-1506)AGT>AGA	p.S502R	SMTN_uc003ajk.1_Missense_Mutation_p.S502R|SMTN_uc003ajm.1_Missense_Mutation_p.S502R|SMTN_uc011ale.1_Missense_Mutation_p.S556R|SMTN_uc011alf.1_Missense_Mutation_p.S558R|SMTN_uc003ajn.1_Missense_Mutation_p.S494R|SMTN_uc011alg.1_Intron|SMTN_uc003ajo.1_5'Flank|SMTN_uc011alh.1_5'Flank|SMTN_uc010gwe.1_5'Flank	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	502					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						TCAGCACCAGTAGTGGGGGCA	0.647			NA											3	21					0	0	0.009096	0	0
FBLN1	2192	broad.mit.edu	37	22	45929753	45929753	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr22:45929753G>T	uc003bgj.1	+	7	906	c.759G>T	c.(757-759)GAG>GAT	p.E253D	FBLN1_uc003bgg.1_Missense_Mutation_p.E253D|FBLN1_uc003bgh.2_Missense_Mutation_p.E253D|FBLN1_uc010gzz.2_Missense_Mutation_p.E291D|FBLN1_uc003bgi.1_Missense_Mutation_p.E253D	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	253	EGF-like 2; calcium-binding (Potential).				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CTGGCTATGAGCTCACAGAGG	0.612			NA											11	141					2.80697e-09	4.14398e-09	0.000978	1	0
BRD1	23774	broad.mit.edu	37	22	50167916	50167916	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr22:50167916C>A	uc003biv.2	-	12	3629	c.3142G>T	c.(3142-3144)GGG>TGG	p.G1048W	BRD1_uc011arf.1_Missense_Mutation_p.G774W|BRD1_uc011arg.1_Missense_Mutation_p.G1097W|BRD1_uc011arh.1_Missense_Mutation_p.G1048W|BRD1_uc003biu.3_Missense_Mutation_p.G1179W	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	1048					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTCGGCTCCCCGTGGACGCGG	0.552			NA											27	168					2.79863e-10	4.23189e-10	0.004656	1	0
BTD	686	broad.mit.edu	37	3	15677046	15677046	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:15677046G>T	uc003cah.2	+	2	263	c.160G>T	c.(160-162)GAG>TAG	p.E54*	BTD_uc011avv.1_Nonsense_Mutation_p.E56*|BTD_uc011avw.1_Nonsense_Mutation_p.E56*|BTD_uc011avx.1_Nonsense_Mutation_p.E34*	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	54					central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						TGACCATCACGAGGCTGAATA	0.562			NA											14	91					3.27435e-08	4.67408e-08	0.00245	1	0
CRTAP	10491	broad.mit.edu	37	3	33174052	33174052	+	Missense_Mutation	SNP	G	G	C	rs111525897		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:33174052G>C	uc003cfl.3	+	5	1048	c.928G>C	c.(928-930)GAC>CAC	p.D310H	CRTAP_uc010hfz.2_Missense_Mutation_p.D267H|CRTAP_uc003cfm.2_Missense_Mutation_p.D131H|CRTAP_uc003cfn.2_Missense_Mutation_p.D131H	NM_006371	NP_006362	O75718	CRTAP_HUMAN	cartilage associated protein precursor	310						proteinaceous extracellular matrix	binding				0						CCTAGTGAACGACCTGAAGAA	0.453			NA											13	134					0	0	0.001855	0	0
SCN10A	6336	broad.mit.edu	37	3	38739040	38739040	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:38739040C>T	uc003ciq.2	-	27	5671	c.5671G>A	c.(5671-5673)GAT>AAT	p.D1891N		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1891					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AAACCTTCATCTGGGAGTGAT	0.498			NA											12	67					0	0	0.000978	0	0
SCN11A	11280	broad.mit.edu	37	3	38888217	38888217	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:38888217C>T	uc011ays.1	-	26	5543	c.5344G>A	c.(5344-5346)GGG>AGG	p.G1782R		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1782					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTGGCCACCCCAAAGCTAGAC	0.473			NA											8	63					0	0	0.00308	0	0
EIF1B	10289	broad.mit.edu	37	3	40352529	40352529	+	Silent	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:40352529T>A	uc003ckc.2	+	2	437	c.177T>A	c.(175-177)CTT>CTA	p.L59L	uc003ckb.2_5'Flank	NM_005875	NP_005866	O60739	EIF1B_HUMAN	translation factor sui1 homolog	59					regulation of translational initiation		protein binding|translation initiation factor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0509)|Kidney(284;0.064)		AAAAGAAACTTGTGAAAGCTT	0.398			NA											7	58					0	0	0.006214	0	0
MAP4	4134	broad.mit.edu	37	3	47956349	47956349	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:47956349G>C	uc003csb.2	-	8	2483	c.1957C>G	c.(1957-1959)CCA>GCA	p.P653A	MAP4_uc003csc.3_Missense_Mutation_p.P653A|MAP4_uc011bbf.1_Missense_Mutation_p.P630A|MAP4_uc003csf.3_Missense_Mutation_p.P670A	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	653					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CTGTTGCATGGTTTCCTTTCC	0.433			NA											22	172					0	0	0.010504	0	0
FLNB	2317	broad.mit.edu	37	3	58120479	58120479	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:58120479C>A	uc003djj.2	+	27	4816	c.4651C>A	c.(4651-4653)CTG>ATG	p.L1551M	FLNB_uc010hne.2_Missense_Mutation_p.L1582M|FLNB_uc003djk.2_Missense_Mutation_p.L1551M|FLNB_uc010hnf.2_Missense_Mutation_p.L1551M|FLNB_uc003djl.2_Missense_Mutation_p.L1382M|FLNB_uc003djm.2_Missense_Mutation_p.L1382M	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1551	Filamin 14.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CGGGGAAGGCCTGCTTGCTGT	0.483			NA											10	129					1.41608e-15	2.29601e-15	0.001855	1	0
MAGI1	9223	broad.mit.edu	37	3	65342407	65342407	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:65342407C>G	uc003dmn.2	-	23	4561	c.4035G>C	c.(4033-4035)AAG>AAC	p.K1345N	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1374					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CGTCTCGTCTCTTCTCGTGCT	0.692			NA											12	56					0	0	0.00245	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433087	73433087	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:73433087G>T	uc003dpl.1	-	10	2726	c.2630C>A	c.(2629-2631)GCC>GAC	p.A877D	PDZRN3_uc011bgh.1_Missense_Mutation_p.A534D|PDZRN3_uc010hoe.1_Missense_Mutation_p.A575D|PDZRN3_uc011bgf.1_Missense_Mutation_p.A594D|PDZRN3_uc011bgg.1_Missense_Mutation_p.A597D	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	877							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GTAGTGCTGGGCGTGCGCCGG	0.647			NA											8	69					5.18039e-06	6.90309e-06	0.00308	1	0
VGLL3	389136	broad.mit.edu	37	3	87017813	87017813	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:87017813G>A	uc003dqn.2	-	3	1228	c.864C>T	c.(862-864)ACC>ACT	p.T288T		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		AGGTAGCAGAGGTGACTGTAG	0.522			NA											8	43					0	0	0.006214	0	0
OR5H6	79295	broad.mit.edu	37	3	97983997	97983997	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:97983997A>T	uc003dsi.1	+	1	869	c.869A>T	c.(868-870)GAG>GTG	p.E290V		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						GATATGATGGAGTCTCTATTT	0.403			NA											5	66					0	0	0.001168	0	0
ZBTB20	26137	broad.mit.edu	37	3	114069321	114069321	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:114069321T>A	uc003ebi.2	-	4	1784	c.1604A>T	c.(1603-1605)CAG>CTG	p.Q535L	ZBTB20_uc003ebj.2_Missense_Mutation_p.Q462L|ZBTB20_uc010hqp.2_Missense_Mutation_p.Q462L|ZBTB20_uc003ebk.2_Missense_Mutation_p.Q462L|ZBTB20_uc003ebl.2_Missense_Mutation_p.Q462L|ZBTB20_uc003ebm.2_Missense_Mutation_p.Q462L|ZBTB20_uc003ebn.2_Missense_Mutation_p.Q462L|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CTGGGTCTGCTGGCCTGCCAG	0.652	NSCLC(69;748 1344 9802 11203 30933)		NA											16	69					0	0	0.004007	0	0
LRRC58	116064	broad.mit.edu	37	3	120053875	120053875	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:120053875C>T	uc003edr.2	-	3	837	c.741G>A	c.(739-741)TTG>TTA	p.L247L		NM_001099678	NP_001093148	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	247	LRR 9.										0				GBM - Glioblastoma multiforme(114;0.147)		AACGAACAACCAATGGATTTC	0.403			NA											5	45					0	0	0.001168	0	0
STXBP5L	9515	broad.mit.edu	37	3	121137243	121137243	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:121137243G>C	uc003eec.3	+	27	3498	c.3358G>C	c.(3358-3360)GGT>CGT	p.G1120R	STXBP5L_uc011bji.1_Missense_Mutation_p.G1096R	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	1120					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TCCTGGACCAGGTAGTATAGA	0.502			NA											3	33					0	0	0.000602	0	0
POLQ	10721	broad.mit.edu	37	3	121217437	121217437	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:121217437C>T	uc003eee.3	-	13	2169	c.2040G>A	c.(2038-2040)ATG>ATA	p.M680I		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	680					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CCACCCTTTTCATTGAAGTTG	0.423	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					9	85					0	0	0.004482	0	0
XRN1	54464	broad.mit.edu	37	3	142123810	142123810	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:142123810C>T	uc003eus.2	-	16	1889	c.1822G>A	c.(1822-1824)GAG>AAG	p.E608K	XRN1_uc010huu.2_Missense_Mutation_p.E74K|XRN1_uc003eut.2_Missense_Mutation_p.E608K|XRN1_uc003euu.2_Missense_Mutation_p.E608K|XRN1_uc003euv.1_Missense_Mutation_p.E469K	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	608					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TAGATAAACTCTGTGTCTCTA	0.413			NA											7	85					0	0	0.00308	0	0
EHHADH	1962	broad.mit.edu	37	3	184910894	184910894	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:184910894G>C	uc003fpf.2	-	7	1319	c.1292C>G	c.(1291-1293)ACC>AGC	p.T431S	EHHADH_uc011brs.1_Missense_Mutation_p.T335S	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	431	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	AAAGAAGTGGGTGCCAATGAC	0.448			NA											8	76					0	0	0.00308	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597			NA											2	5					0	0	0.004672	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23833297	23833297	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:23833297G>T	uc003gqs.2	-	3	432	c.312C>A	c.(310-312)GAC>GAA	p.D104E	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	104					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				AGGGCAATCCGTCTTCATCCA	0.512	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											62	278					6.00099e-30	1.05535e-29	0.00361	1	0
TMEM156	80008	broad.mit.edu	37	4	39000506	39000506	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:39000506G>C	uc003gto.2	-	2	220	c.112C>G	c.(112-114)CTG>GTG	p.L38V	TMEM156_uc010ifj.2_Missense_Mutation_p.L38V	NM_024943	NP_079219	Q8N614	TM156_HUMAN	transmembrane protein 156	38	Extracellular (Potential).					integral to membrane				skin(1)	1						CACACTTCCAGACATGATAGC	0.323			NA											13	40					0	0	0.00245	0	0
CORIN	10699	broad.mit.edu	37	4	47765481	47765481	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:47765481G>T	uc003gxm.2	-	4	625	c.532C>A	c.(532-534)CTC>ATC	p.L178I	CORIN_uc011bzf.1_Missense_Mutation_p.L39I|CORIN_uc011bzg.1_Missense_Mutation_p.L111I|CORIN_uc011bzh.1_Missense_Mutation_p.L178I|CORIN_uc011bzi.1_Missense_Mutation_p.L178I|CORIN_uc003gxn.3_Missense_Mutation_p.L178I	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	178	Extracellular (Potential).|FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						AGGCGATGGAGATATGTGAAA	0.493			NA											6	44					3.59834e-05	4.51603e-05	0.001168	1	0
NFXL1	152518	broad.mit.edu	37	4	47900034	47900034	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:47900034C>A	uc010igh.2	-	9	1331	c.1154G>T	c.(1153-1155)TGT>TTT	p.C385F	NFXL1_uc003gxp.2_Missense_Mutation_p.C385F|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Missense_Mutation_p.C385F	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	385	NF-X1-type 3.					integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						ACATTCTCCACAAGCACCAAC	0.318			NA											5	48					5.9392e-07	8.20663e-07	0.001168	1	0
SPATA18	132671	broad.mit.edu	37	4	52926965	52926965	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:52926965G>T	uc003gzl.2	+	3	489	c.211G>T	c.(211-213)GTG>TTG	p.V71L	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.V71L|SPATA18_uc003gzk.1_Missense_Mutation_p.V71L	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	71					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TAATGATGGTGTGGAAACAAT	0.308			NA											18	71					1.67942e-08	2.4345e-08	0.006122	1	0
UBA6	55236	broad.mit.edu	37	4	68504691	68504691	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:68504691T>C	uc003hdg.3	-	19	1758	c.1706A>G	c.(1705-1707)GAT>GGT	p.D569G	UBA6_uc003hdh.1_Missense_Mutation_p.D95G	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	569					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TTCCACATTATCTAATGCTGT	0.343			NA											6	97					0	0	0.001168	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68938203	68938203	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:68938203G>T	uc003hdt.1	-	5	401	c.352C>A	c.(352-354)CCA>ACA	p.P118T	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	118	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TGTTCATCTGGACTGAAGAAC	0.294			NA											11	67					5.50884e-06	7.28881e-06	0.001368	1	0
GRID2	2895	broad.mit.edu	37	4	94690466	94690466	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:94690466A>T	uc011cdt.1	+	15	2724	c.2466A>T	c.(2464-2466)AAA>AAT	p.K822N	GRID2_uc011cdu.1_Missense_Mutation_p.K727N	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	822	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CAAAGCAGAAAGGAGGCGCCC	0.522			NA											6	81					0	0	0.00308	0	0
UNC5C	8633	broad.mit.edu	37	4	96124011	96124011	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:96124011C>A	uc003htp.1	-	12	2161	c.2007G>T	c.(2005-2007)CTG>CTT	p.L669L	UNC5C_uc010ilc.1_Silent_p.L688L	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	669	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AATGTCCTACCAGGGCGTAGG	0.597			NA											16	90					3.32936e-07	4.62319e-07	0.006122	1	0
NDST4	64579	broad.mit.edu	37	4	115997569	115997569	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:115997569G>T	uc003ibu.2	-	2	1303	c.624C>A	c.(622-624)CCC>CCA	p.P208P	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	208	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCTCAACCTTGGGGGCTTTGG	0.398			NA											21	111					7.41877e-09	1.08102e-08	0.001882	1	0
INTU	27152	broad.mit.edu	37	4	128564978	128564978	+	Missense_Mutation	SNP	C	C	T	rs147508682		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:128564978C>T	uc003ifk.1	+	2	519	c.449C>T	c.(448-450)ACA>ATA	p.T150I	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	150										ovary(1)	1						AATCAGAAGACAGGAGTCATT	0.378			NA											16	101					0	0	0.00499	0	0
FGB	2244	broad.mit.edu	37	4	155489541	155489541	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr4:155489541G>A	uc003ioa.3	+	5	766	c.727G>A	c.(727-729)GAA>AAA	p.E243K	FGB_uc003iob.3_Missense_Mutation_p.E240K|FGB_uc010ipv.2_Missense_Mutation_p.E181K|FGB_uc010ipw.2_Missense_Mutation_p.E240K|FGB_uc003ioc.3_Missense_Mutation_p.E24K	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	243	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AGAATGTGAGGAAATTATCAG	0.318	NSCLC(106;1133 1613 21870 46110 52656)		NA											4	79					0	0	0.000602	0	0
DNAH5	1767	broad.mit.edu	37	5	13923425	13923425	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:13923425G>A	uc003jfd.2	-	4	444	c.402C>T	c.(400-402)GAC>GAT	p.D134D	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	134	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTTGGAAGGGTCAGTCCTGA	0.433			NA							Kartagener_syndrome				59	331					0	0	0.00361	0	0
CDH9	1007	broad.mit.edu	37	5	26881273	26881273	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:26881273T>A	uc003jgs.1	-	12	2511	c.2342A>T	c.(2341-2343)TAT>TTT	p.Y781F	CDH9_uc011cnv.1_Missense_Mutation_p.Y374F	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	781	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATCACCCCCATACATATCGGC	0.413	Melanoma(8;187 585 15745 40864 52829)		NA											41	181					0	0	0.00361	0	0
SPEF2	79925	broad.mit.edu	37	5	35776410	35776410	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:35776410T>A	uc003jjo.2	+	29	4241	c.4130T>A	c.(4129-4131)CTT>CAT	p.L1377H	SPEF2_uc003jjp.1_Missense_Mutation_p.L863H|SPEF2_uc003jjr.2_5'UTR	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1377					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCATTGGCTCTTCTTGAAGAT	0.348			NA											5	138					0	0	0.001168	0	0
C6	729	broad.mit.edu	37	5	41186174	41186174	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:41186174C>G	uc003jmk.2	-	6	934	c.724G>C	c.(724-726)GAG>CAG	p.E242Q	C6_uc003jml.1_Missense_Mutation_p.E242Q	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	242	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGTCATACCTCAAAGCCGACA	0.408			NA											8	62					0	0	0.006214	0	0
OXCT1	5019	broad.mit.edu	37	5	41870398	41870398	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:41870398C>T	uc003jmn.2	-	1	394	c.63G>A	c.(61-63)GGG>GGA	p.G21G		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	21					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	ACCAGGTTGCCCCAGATCCGC	0.642			NA											3	23					0	0	0.000602	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64468799	64468799	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:64468799T>G	uc003jtp.2	-	23	3761	c.2947A>C	c.(2947-2949)ATT>CTT	p.I983L	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	983	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CACAGAACAATCCGATGCTTG	0.443			NA											5	111					0	0	0.000602	0	0
BDP1	55814	broad.mit.edu	37	5	70806102	70806102	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:70806102G>T	uc003kbp.1	+	17	3446	c.3183G>T	c.(3181-3183)GAG>GAT	p.E1061D	BDP1_uc003kbn.1_Missense_Mutation_p.E1061D|BDP1_uc003kbo.2_Missense_Mutation_p.E1061D	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1061	5.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GTGAAATGGAGACGGATTTGA	0.433			NA											7	73					0.00198382	0.00223928	0.001984	1	0
PRR16	51334	broad.mit.edu	37	5	120021828	120021828	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:120021828C>T	uc003ksq.2	+	2	502	c.339C>T	c.(337-339)ATC>ATT	p.I113I	PRR16_uc003ksp.2_Silent_p.I90I|PRR16_uc003ksr.2_Silent_p.I43I	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	113	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CGTCTGCTATCCTCACGGTCC	0.527			NA											6	81					0	0	0.001984	0	0
FBN2	2201	broad.mit.edu	37	5	127686665	127686666	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:127686665_127686666GG>TT	uc003kuu.2	-	21	3145_3146	c.2706_2707CC>AA	c.(2704-2709)ATCCAG>ATAAAG	p.Q903K	FBN2_uc003kuv.2_Missense_Mutation_p.Q870K	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	903	TB 4.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CGGCTGTCCTGGATGTTGAGCC	0.53			NA											11	64					0	0	0.004672	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128862031	128862031	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:128862031A>T	uc003kvb.1	+	4	950	c.950A>T	c.(949-951)TAT>TTT	p.Y317F	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	317					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GGGAAACGATATTCATACAAA	0.393			NA											5	77					0	0	0.001168	0	0
TRPC7	57113	broad.mit.edu	37	5	135549258	135549258	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:135549258G>T	uc003lbn.1	-	11	2454	c.2451C>A	c.(2449-2451)AGC>AGA	p.S817R	TRPC7_uc010jef.1_Missense_Mutation_p.S754R|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.S748R|TRPC7_uc010jei.1_Missense_Mutation_p.S693R|TRPC7_uc010jej.1_Missense_Mutation_p.S369R	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	818	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CATAGCGCAGGCTGGAGATAT	0.483			NA											13	42					5.50884e-06	7.28881e-06	0.001368	1	0
PCDHA4	56144	broad.mit.edu	37	5	140186910	140186910	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:140186910C>A	uc003lhi.2	+	1	239	c.138C>A	c.(136-138)GGC>GGA	p.G46G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.G46G|PCDHA4_uc011daa.1_Silent_p.G46G	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	46	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTCGTGGGCCGCATCGCGC	0.662			NA											16	61					6.72482e-11	1.02239e-10	0.003163	1	0
PCDHA4	56144	broad.mit.edu	37	5	140189058	140189058	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:140189058G>T	uc003lhi.2	+	1	2387	c.2286G>T	c.(2284-2286)GAG>GAT	p.E762D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.E762D|PCDHA4_uc011daa.1_Missense_Mutation_p.E762D	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	762	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCTGGTGAGGGCCCACCCA	0.622			NA											21	69					2.4624e-09	3.64487e-09	0.008871	1	0
PCDHA11	56138	broad.mit.edu	37	5	140250586	140250586	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:140250586C>A	uc003lia.2	+	1	2756	c.1898C>A	c.(1897-1899)ACG>AAG	p.T633K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.T633K	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	633	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAAGCACAACGCGTGCCCTG	0.662			NA											10	44					5.50884e-06	7.28881e-06	0.001368	1	0
PCDHB10	56126	broad.mit.edu	37	5	140573083	140573083	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:140573083C>G	uc003lix.2	+	1	1132	c.958C>G	c.(958-960)CAG>GAG	p.Q320E		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	320	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATAAATATACAGGCAATGGA	0.368			NA											4	97					0	0	0.009096	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589623	140589623	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:140589623G>T	uc003liz.2	+	1	1333	c.1144G>T	c.(1144-1146)GTT>TTT	p.V382F	PCDHB12_uc011dak.1_Missense_Mutation_p.V45F	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	382	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGAAAGATGGTTTGTTCTAT	0.458			NA											10	38					1.08611e-07	1.52708e-07	0.000978	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140774087	140774087	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:140774087A>G	uc003lkd.1	+	1	2605	c.1707A>G	c.(1705-1707)ACA>ACG	p.T569T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.T569T	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	569	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCCCCACAGACGGTTCCA	0.667			NA											6	117					0	0	0.004482	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149215939	149215939	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:149215939G>T	uc003lrc.2	+	8	1963	c.1921G>T	c.(1921-1923)GGC>TGC	p.G641C	PPARGC1B_uc003lrb.1_Missense_Mutation_p.G641C|PPARGC1B_uc003lrd.2_Missense_Mutation_p.G602C|PPARGC1B_uc003lrf.2_Missense_Mutation_p.G620C|PPARGC1B_uc003lre.1_Missense_Mutation_p.G620C	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	641					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CTCCCCTGAGGGCCTCTCACT	0.592			NA											6	90					3.59834e-05	4.51603e-05	0.001168	1	0
HAVCR1	26762	broad.mit.edu	37	5	156469677	156469677	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:156469677C>A	uc010jij.1	-	6	983	c.798G>T	c.(796-798)GTG>GTT	p.V266V	HAVCR1_uc011ddl.1_Silent_p.V97V|HAVCR1_uc003lwi.2_Silent_p.V266V	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	261	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAGACTCTGTCACGGTGTCAT	0.348			NA											12	125					1.52009e-12	2.36881e-12	0.003163	1	0
FAM71B	153745	broad.mit.edu	37	5	156589905	156589905	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:156589905C>A	uc003lwn.2	-	2	1471	c.1371G>T	c.(1369-1371)GCG>GCT	p.A457A		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	457	Bipartite nuclear localization signal (Potential).					nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTGTCCCCCGCTCTCCTGC	0.483			NA											30	148					2.08457e-15	3.36047e-15	0.002096	1	0
CYFIP2	26999	broad.mit.edu	37	5	156819862	156819862	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:156819862C>T	uc003lwq.2	+	33	3754	c.3616C>T	c.(3616-3618)CGG>TGG	p.R1206W	CYFIP2_uc011ddn.1_Missense_Mutation_p.R1180W|CYFIP2_uc011ddo.1_Missense_Mutation_p.R1010W|CYFIP2_uc003lwr.2_Missense_Mutation_p.R1206W|CYFIP2_uc003lws.2_Missense_Mutation_p.R1206W|CYFIP2_uc003lwt.2_Missense_Mutation_p.R1109W|CYFIP2_uc011ddp.1_Missense_Mutation_p.R940W|CYFIP2_uc003lwv.2_Missense_Mutation_p.R161W	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1231					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATGGCCGACCGGATCAGGAA	0.498			NA											5	95					0	0	0.001168	0	0
GABRG2	2566	broad.mit.edu	37	5	161580234	161580234	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:161580234G>T	uc003lyz.3	+	9	1622	c.1264G>T	c.(1264-1266)GAA>TAA	p.E422*	GABRG2_uc010jjc.2_Nonsense_Mutation_p.E470*|GABRG2_uc003lyy.3_Nonsense_Mutation_p.E430*|GABRG2_uc011dej.1_Nonsense_Mutation_p.E327*	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	422	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CTGCTGTTTTGAAGATTGTCG	0.468			NA											27	97					3.01185e-09	4.43477e-09	0.003954	1	0
ODZ2	57451	broad.mit.edu	37	5	167642143	167642143	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:167642143C>A	uc010jjd.2	+	21	3917	c.3917C>A	c.(3916-3918)TCT>TAT	p.S1306Y	ODZ2_uc003lzr.3_Missense_Mutation_p.S1076Y|ODZ2_uc003lzt.3_Missense_Mutation_p.S679Y|ODZ2_uc010jje.2_Missense_Mutation_p.S570Y	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CGCGTCAAGTCTCTGAGTGGA	0.582			NA											10	58					7.48243e-07	1.02883e-06	0.006214	1	0
DOCK2	1794	broad.mit.edu	37	5	169446071	169446071	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:169446071A>C	uc003maf.2	+	33	3420	c.3340A>C	c.(3340-3342)ATG>CTG	p.M1114L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.M606L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1114	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTCTTCGACATGATGCTGTG	0.463			NA											47	214					0	0	0.00361	0	0
HRH2	3274	broad.mit.edu	37	5	175110816	175110816	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:175110816C>G	uc003mdd.2	+	1	2353	c.580C>G	c.(580-582)CCG>GCG	p.P194A	HRH2_uc003mdc.3_Missense_Mutation_p.P194A	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	194	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CTTCTACCTCCCGCTACTGAT	0.542			NA											4	51					0	0	0.009096	0	0
F13A1	2162	broad.mit.edu	37	6	6145961	6145961	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:6145961C>A	uc003mwv.2	-	15	2213	c.2090G>T	c.(2089-2091)CGG>CTG	p.R697L	F13A1_uc011dib.1_Missense_Mutation_p.G591C	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	697					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GACCCAGGGCCGGCACACTTC	0.542			NA											16	74					6.94344e-10	1.04152e-09	0.006122	1	0
GCNT2	2651	broad.mit.edu	37	6	10529565	10529565	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:10529565A>G	uc010joo.2	+	3	972	c.421A>G	c.(421-423)AAA>GAA	p.K141E	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Missense_Mutation_p.K140E|GCNT2_uc010jon.2_Missense_Mutation_p.K140E	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	141	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AGGTGCAGTGAAACAGTTACT	0.517			NA											13	100					0	0	0.00245	0	0
CCDC90A	63933	broad.mit.edu	37	6	13802537	13802537	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:13802537C>T	uc003nbd.2	-	3	705	c.577G>A	c.(577-579)GTC>ATC	p.V193I	CCDC90A_uc010jpf.2_RNA	NM_001031713	NP_001026883	Q96AQ8	CC90A_HUMAN	coiled-coil domain containing 90A precursor	193						integral to membrane|mitochondrion					0	Breast(50;0.0027)|Ovarian(93;0.0964)	all_hematologic(90;0.117)				AGGATCTTGACCAATGCAGAC	0.438			NA											14	106					0	0	0.003163	0	0
OR14J1	442191	broad.mit.edu	37	6	29274833	29274833	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:29274833G>T	uc011dln.1	+	1	367	c.367G>T	c.(367-369)GCA>TCA	p.A123S		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAGGTACGCAGCAATCTGTCA	0.478			NA											46	116					7.88023e-25	1.3772e-24	0.00361	1	0
OR5V1	81696	broad.mit.edu	37	6	29323943	29323943	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:29323943A>G	uc011dlo.1	-	1	112	c.30T>C	c.(28-30)ACT>ACC	p.T10T		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						TGATGAATTCAGTTATAGCTG	0.353	Ovarian(32;43 883 21137 32120 42650)		NA											40	72					0	0	0.00874	0	0
DPCR1	135656	broad.mit.edu	37	6	30920784	30920784	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:30920784C>G	uc003nsg.2	+	3	4072	c.4072C>G	c.(4072-4074)CAG>GAG	p.Q1358E		NM_080870	NP_543146	Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	482	Cytoplasmic (Potential).					integral to membrane					0						CACACTAACCCAGAACACCCA	0.522			NA											8	38					0	0	0.00308	0	0
TNXB	7148	broad.mit.edu	37	6	31977528	31977528	+	Missense_Mutation	SNP	C	C	G	rs116018894	by1000genomes	TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:31977528C>G	uc011dpc.1	-	12	2376	c.1467G>C	c.(1465-1467)TGG>TGC	p.W489C		NM_032470	NP_115859	P22105	TENX_HUMAN	tenascin XB isoform 2	4105	Fibrinogen C-terminal.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTCCATGTCCCAAAACACGT	0.667			NA											5	26					0	0	0.00308	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169207	32169207	+	Missense_Mutation	SNP	C	C	G	rs139568674		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:32169207C>G	uc003obb.2	-	22	3965	c.3826G>C	c.(3826-3828)GAG>CAG	p.E1276Q	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1276	LNR 3.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CAGCCACACTCTGCAGTGTTG	0.617			NA											5	60					0	0	0.000602	0	0
NOTCH4	4855	broad.mit.edu	37	6	32181503	32181503	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:32181503C>A	uc003obb.2	-	14	2421	c.2282G>T	c.(2281-2283)GGG>GTG	p.G761V	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	761	EGF-like 19.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCACTGGGGCCCTGTGTGGCT	0.587			NA											14	90					2.32078e-09	3.44434e-09	0.003163	1	0
HLA-DMB	3109	broad.mit.edu	37	6	32903146	32903146	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:32903146G>A	uc003ocl.1	-	5	981	c.748C>T	c.(748-750)CCT>TCT	p.P250S	HLA-DMB_uc003ocj.1_3'UTR|HLA-DMB_uc003ock.1_RNA|HLA-DMB_uc010jud.1_Intron|HLA-DMB_uc010jue.1_Missense_Mutation_p.P80S|HLA-DMB_uc010juf.1_Intron	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	250	YXXZ motif.|Cytoplasmic (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						CCAGGAAGAGGAGTGTAACCT	0.438			NA											10	126					0	0	0.000978	0	0
PKHD1	5314	broad.mit.edu	37	6	51524526	51524526	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:51524526C>T	uc003pah.1	-	61	10674	c.10398G>A	c.(10396-10398)AGG>AGA	p.R3466R		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3466	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGGTGATTTGCCTGATGGGTA	0.408			NA											12	158					0	0	0.000978	0	0
GSTA5	221357	broad.mit.edu	37	6	52701131	52701131	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:52701131C>G	uc003pba.1	-	4	245	c.175G>C	c.(175-177)GAG>CAG	p.E59Q		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	59	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	CCGTCAATCTCAACCATTGGT	0.423			NA											12	266					0	0	0.001368	0	0
FAM83B	222584	broad.mit.edu	37	6	54805963	54805963	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:54805963G>A	uc003pck.2	+	5	2310	c.2194G>A	c.(2194-2196)GGC>AGC	p.G732S		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	732										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CTCTCCAAGTGGCACTACTAC	0.408			NA											8	146					0	0	0.004482	0	0
ZNF451	26036	broad.mit.edu	37	6	56999642	56999642	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:56999642C>T	uc003pdm.1	+	7	900	c.676C>T	c.(676-678)CAA>TAA	p.Q226*	ZNF451_uc003pdl.2_Nonsense_Mutation_p.Q226*|ZNF451_uc003pdn.1_Nonsense_Mutation_p.Q226*|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Nonsense_Mutation_p.Q226*	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TACTCAACAACAATATAGAGA	0.343			NA											8	70					0	0	0.00308	0	0
COL9A1	1297	broad.mit.edu	37	6	70964868	70964868	+	Silent	SNP	C	C	A	rs145650924		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:70964868C>A	uc003pfg.3	-	23	1755	c.1596G>T	c.(1594-1596)GGG>GGT	p.G532G	COL9A1_uc003pfe.3_Silent_p.G105G|COL9A1_uc003pff.3_Silent_p.G289G	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	532	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CTCCTTTGGGCCCAGGGAGAC	0.423			NA											35	117					6.5261e-18	1.09288e-17	0.00874	1	0
CD109	135228	broad.mit.edu	37	6	74521964	74521964	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:74521964G>C	uc003php.2	+	29	4164	c.3739G>C	c.(3739-3741)GCA>CCA	p.A1247P	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.A1230P|CD109_uc010kba.2_Missense_Mutation_p.A1170P	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	1247						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TAATATTTCCGCAAATGGTTT	0.318			NA											36	74					0	0	0.007835	0	0
GPR6	2830	broad.mit.edu	37	6	110300445	110300445	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:110300445C>A	uc011eaw.1	+	2	310	c.130C>A	c.(130-132)CTA>ATA	p.L44I	GPR6_uc011eav.1_Missense_Mutation_p.L59I|GPR6_uc003ptu.2_Missense_Mutation_p.L44I	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	44	Extracellular (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		TGCGGCGGCTCTAGGAGCCGG	0.493			NA											28	56					7.01153e-11	1.0631e-10	0.007291	1	0
HS3ST5	222537	broad.mit.edu	37	6	114378649	114378649	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:114378649C>T	uc003pwg.3	-	2	845	c.813G>A	c.(811-813)AAG>AAA	p.K271K	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Silent_p.K271K	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	271	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GATTTAGGAACTTCTCCACGA	0.413			NA											11	72					0	0	0.001368	0	0
TAAR1	134864	broad.mit.edu	37	6	132966566	132966566	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:132966566G>C	uc003qdm.1	-	1	577	c.577C>G	c.(577-579)CTG>GTG	p.L193V		NM_138327	NP_612200	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	193	Helical; Name=5; (Potential).					plasma membrane					0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	ATAAAGGTCAGTACCCCAGAT	0.353			NA											17	92					0	0	0.004007	0	0
UST	10090	broad.mit.edu	37	6	149275032	149275032	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:149275032A>G	uc003qmg.2	+	4	768	c.472A>G	c.(472-474)ACT>GCT	p.T158A		NM_005715	NP_005706	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	158	Lumenal (Potential).				protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			ovary(2)	2		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		AAATATAAGTACTGCCGAACA	0.299			NA											4	35					0	0	0.001168	0	0
TULP4	56995	broad.mit.edu	37	6	158882747	158882747	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:158882747G>T	uc003qrf.2	+	6	2369	c.1012G>T	c.(1012-1014)GAC>TAC	p.D338Y	TULP4_uc011efo.1_Missense_Mutation_p.D338Y|TULP4_uc003qrg.2_Missense_Mutation_p.D338Y	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	338					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CTTCACACTGGACACTCTCGT	0.428			NA											20	56					1.9806e-07	2.77086e-07	0.002299	1	0
FNDC1	84624	broad.mit.edu	37	6	159653518	159653518	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:159653518C>A	uc010kjv.2	+	11	2174	c.1974C>A	c.(1972-1974)CAC>CAA	p.H658Q	FNDC1_uc010kjw.1_Missense_Mutation_p.H543Q	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	658						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCTCCCTCCACCCCAAGGGCG	0.677			NA											8	33					0.000274275	0.000324617	0.004482	1	0
LPA	4018	broad.mit.edu	37	6	161032655	161032655	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:161032655G>T	uc003qtl.2	-	17	2662	c.2542C>A	c.(2542-2544)CAA>AAA	p.Q848K		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3356	Kringle 30.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GACCAAGCTTGGCAGGTTCTT	0.507			NA											38	242					9.59449e-18	1.60194e-17	0.00361	1	0
PLG	5340	broad.mit.edu	37	6	161173185	161173185	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:161173185C>A	uc003qtm.3	+	18	2227	c.2164C>A	c.(2164-2166)CCT>ACT	p.P722T		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	722	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AGCCCAGCTCCCTGTGATTGA	0.473			NA											16	48					0.00316338	0.00355642	0.003163	1	0
RBAK	57786	broad.mit.edu	37	7	5104882	5104882	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:5104882G>T	uc010kss.1	+	6	2119	c.1795G>T	c.(1795-1797)GAA>TAA	p.E599*	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Nonsense_Mutation_p.E599*	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	599	C2H2-type 13.|Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TGAATGTTACGAATGTGGAAA	0.378			NA											3	60					6.4e-05	7.85819e-05	0.004672	1	0
DGKB	1607	broad.mit.edu	37	7	14378261	14378261	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:14378261A>C	uc003ssz.2	-	22	2191	c.2004T>G	c.(2002-2004)CAT>CAG	p.H668Q	DGKB_uc011jxt.1_Missense_Mutation_p.H649Q|DGKB_uc003sta.2_Missense_Mutation_p.H668Q|DGKB_uc011jxu.1_Missense_Mutation_p.H667Q	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	668					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TGGATCCTCCATGCATGCTTG	0.403			NA											13	99					0	0	0.001368	0	0
HOXA2	3199	broad.mit.edu	37	7	27140891	27140891	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:27140891C>A	uc003syh.2	-	2	860	c.585G>T	c.(583-585)AGG>AGT	p.R195S		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	195	Homeobox.					nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TGTGCTTCATCCTCCGGTTCT	0.493			NA											17	85					6.94344e-10	1.04152e-09	0.006122	1	0
ELMO1	9844	broad.mit.edu	37	7	36917705	36917705	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:36917705G>T	uc003tfk.1	-	19	2039	c.1732C>A	c.(1732-1734)CGG>AGG	p.R578R	ELMO1_uc003tfi.1_Silent_p.R98R|ELMO1_uc003tfj.1_Silent_p.R98R|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Silent_p.R482R|ELMO1_uc010kxg.1_Silent_p.R578R	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	578	PH.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GGCGAAAGCCGACAATACCAA	0.418			NA											5	57					0.000602214	0.000699466	0.000602	1	0
POLM	27434	broad.mit.edu	37	7	44113476	44113476	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:44113476C>A	uc003tjt.2	-	9	1312	c.1220G>T	c.(1219-1221)AGG>ATG	p.R407M	POLM_uc003tjw.1_Missense_Mutation_p.R26M|POLM_uc003tju.2_Missense_Mutation_p.R370M|POLM_uc003tjx.2_Missense_Mutation_p.R327M|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Missense_Mutation_p.R57M	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	407					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						TGGGCAGGGCCTCGTGGATCC	0.612			NA						DNA_polymerases_(catalytic_subunits)					19	78					0.00152264	0.00173266	0.010504	1	0
TBRG4	9238	broad.mit.edu	37	7	45141142	45141142	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:45141142G>A	uc003tmv.2	-	9	1765	c.1639C>T	c.(1639-1641)CAG>TAG	p.Q547*	TBRG4_uc003tmu.2_Nonsense_Mutation_p.Q372*|TBRG4_uc003tmw.2_Nonsense_Mutation_p.Q437*|TBRG4_uc003tmx.2_Nonsense_Mutation_p.Q437*|TBRG4_uc011kcd.1_Nonsense_Mutation_p.Q558*	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	547					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						CCAGTTGGCTGGGCAAGGTGA	0.592			NA											5	19					0	0	0.000602	0	0
ADCY1	107	broad.mit.edu	37	7	45650023	45650023	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:45650023A>T	uc003tne.3	+	3	853	c.835A>T	c.(835-837)ATG>TTG	p.M279L	ADCY1_uc003tnd.2_Missense_Mutation_p.M54L	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	279	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGCCATGGAGATGAAGGAGGA	0.602			NA											15	146					0	0	0.006122	0	0
UPP1	7378	broad.mit.edu	37	7	48143002	48143002	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:48143002G>A	uc003toj.2	+	7	959	c.430G>A	c.(430-432)GGG>AGG	p.G144R	UPP1_uc003tok.2_Missense_Mutation_p.G144R|UPP1_uc003tol.2_Missense_Mutation_p.G144R|UPP1_uc011kcg.1_Missense_Mutation_p.G144R|UPP1_uc011kch.1_Intron|UPP1_uc003ton.2_Intron|UPP1_uc003too.2_Intron	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	144					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						CACTTCTGGTGGGATAGGTAA	0.522			NA											6	89					0	0	0.001168	0	0
POM121L12	285877	broad.mit.edu	37	7	53104146	53104146	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:53104146C>A	uc003tpz.2	+	1	798	c.782C>A	c.(781-783)CCA>CAA	p.P261Q		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	261											0						CAGCCCGCCCCATCCGCCATC	0.652			NA											9	47					5.16669e-11	7.87639e-11	0.000978	1	0
WBSCR27	155368	broad.mit.edu	37	7	73249147	73249147	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:73249147G>A	uc003tzj.2	-	6	704	c.664C>T	c.(664-666)CTG>TTG	p.L222L	RFC2_uc011kfa.1_Intron	NM_152559	NP_689772	Q8N6F8	WBS27_HUMAN	Williams-Beuren syndrome chromosome region 27	222										central_nervous_system(1)	1		Lung NSC(55;0.159)				ATCCTTGGCAGAGATGCCGGA	0.642			NA											5	51					0	0	0.001168	0	0
RFC2	5982	broad.mit.edu	37	7	73668693	73668693	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:73668693A>G	uc003uaj.2	-	1	46	c.21T>C	c.(19-21)TGT>TGC	p.C7C	RFC2_uc011kfa.1_RNA|RFC2_uc003uak.2_Silent_p.C7C|RFC2_uc010lbp.2_5'UTR|RFC2_uc003ual.2_5'UTR	NM_181471	NP_852136	P35250	RFC2_HUMAN	replication factor C 2 isoform 1	7					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			liver(1)|central_nervous_system(1)	2						CCGCGCCACCACAGACGGCCT	0.736			NA											3	8					0	0	0.004672	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73952477	73952477	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:73952477G>C	uc003uaq.2	+	12	1814	c.1421G>C	c.(1420-1422)GGC>GCC	p.G474A	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.G506A|GTF2IRD1_uc003uap.2_Missense_Mutation_p.G474A|GTF2IRD1_uc003uar.1_Missense_Mutation_p.G474A	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	474						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						TCAGACAAGGGCAGCATGTCT	0.652			NA											6	80					0	0	0.00308	0	0
CACNA2D1	781	broad.mit.edu	37	7	81624225	81624225	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:81624225C>G	uc003uhr.1	-	20	1949	c.1693G>C	c.(1693-1695)GGA>CGA	p.G565R		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	584	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GTTTTTTCTCCACTTTCCCCA	0.289			NA											7	63					0	0	0.00308	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762155	92762155	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:92762155G>T	uc003umh.1	-	5	4346	c.3130C>A	c.(3130-3132)CGC>AGC	p.R1044S	SAMD9L_uc003umj.1_Missense_Mutation_p.R1044S|SAMD9L_uc003umi.1_Missense_Mutation_p.R1044S|SAMD9L_uc010lfb.1_Missense_Mutation_p.R1044S|SAMD9L_uc003umk.1_Missense_Mutation_p.R1044S|SAMD9L_uc010lfc.1_Missense_Mutation_p.R1044S|SAMD9L_uc010lfd.1_Missense_Mutation_p.R1044S|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1044										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TACACCTTGCGCTGTCTTGTA	0.358			NA											15	109					1.49906e-05	1.92884e-05	0.00245	1	0
SERPINE1	5054	broad.mit.edu	37	7	100777155	100777155	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:100777155C>T	uc003uxt.2	+	5	1028	c.880C>T	c.(880-882)CGC>TGC	p.R294C	SERPINE1_uc011kkj.1_Missense_Mutation_p.R279C|SERPINE1_uc003uxu.1_Missense_Mutation_p.R125C	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	294					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	CAGGCTGCCCCGCCTCCTGGT	0.587			NA											3	37					0	0	0.009096	0	0
CUX1	1523	broad.mit.edu	37	7	101845330	101845330	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:101845330C>T	uc003uyx.3	+	18	2791	c.2753C>T	c.(2752-2754)CCC>CTC	p.P918L	CUX1_uc003uys.3_Missense_Mutation_p.P929L|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	918					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CCGATCGTGCCCATGTCCAAG	0.657			NA											9	62					0	0	0.000978	0	0
RELN	5649	broad.mit.edu	37	7	103163929	103163929	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:103163929G>T	uc003vca.2	-	47	7559	c.7399C>A	c.(7399-7401)CAG>AAG	p.Q2467K	RELN_uc010liz.2_Missense_Mutation_p.Q2467K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2467					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CATGTCTGCTGCTTGTCAAAA	0.468	NSCLC(146;835 1944 15585 22231 52158)		NA											22	111					1.9806e-07	2.77086e-07	0.002299	1	0
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507			NA											10	22					0	0	0.00361	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121651013	121651013	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:121651013G>A	uc003vjy.2	+	12	2308	c.1913G>A	c.(1912-1914)GGT>GAT	p.G638D	PTPRZ1_uc003vjz.2_Missense_Mutation_p.G638D|PTPRZ1_uc011knt.1_Missense_Mutation_p.G88D	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	638	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACTTCATCAGGTTCAGAAGAA	0.423			NA											14	94					0	0	0.003163	0	0
SPAM1	6677	broad.mit.edu	37	7	123594501	123594501	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:123594501G>C	uc003vld.2	+	4	1279	c.877G>C	c.(877-879)GAT>CAT	p.D293H	SPAM1_uc003vle.2_Missense_Mutation_p.D293H|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.D293H|SPAM1_uc010lku.2_Missense_Mutation_p.D293H	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	293					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	CAAAATACCTGATGCAAAAAG	0.413			NA											14	58					0	0	0.003163	0	0
DGKI	9162	broad.mit.edu	37	7	137148322	137148322	+	Missense_Mutation	SNP	C	C	A	rs78898727		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:137148322C>A	uc003vtt.2	-	28	2673	c.2672G>T	c.(2671-2673)CGC>CTC	p.R891L	DGKI_uc003vtu.2_Intron	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	891					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ACTCAGCATGCGTTTCCGCAG	0.507			NA											6	39					3.59834e-05	4.51603e-05	0.001168	1	0
BRAF	673	broad.mit.edu	37	7	140494268	140494268	+	Splice_Site	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:140494268C>A	uc003vwc.3	-	8	1042	c.981_splice	c.e8-1	p.G327_splice		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf						activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	AATTTGGGGCCTGGAAAAATG	0.363	Colon(40;35 892 2973 5743 27438)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				4	84					1.23904e-05	1.60532e-05	0.000602	1	0
EPHB6	2051	broad.mit.edu	37	7	142568118	142568118	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:142568118G>A	uc011kst.1	+	18	3546	c.2759G>A	c.(2758-2760)CGC>CAC	p.R920H	EPHB6_uc011ksu.1_Missense_Mutation_p.R920H|EPHB6_uc003wbs.2_Missense_Mutation_p.R628H|EPHB6_uc003wbt.2_Missense_Mutation_p.R394H|EPHB6_uc003wbu.2_Missense_Mutation_p.R628H|EPHB6_uc003wbv.2_Missense_Mutation_p.R304H	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	920	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					AAGATGATCCGCAAGCCAGAT	0.572			NA											27	111					0	0	0.00632	0	0
KEL	3792	broad.mit.edu	37	7	142651453	142651453	+	Missense_Mutation	SNP	G	G	A	rs61728832		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:142651453G>A	uc003wcb.2	-	8	952	c.742C>T	c.(742-744)CGG>TGG	p.R248W		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	248	Extracellular (Potential).		R -> Q (in KEL25 antigen).		proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					AGGTATTCCCGAAAGATCTGG	0.527			NA											11	74					0	0	0.001855	0	0
CLCN1	1180	broad.mit.edu	37	7	143039237	143039237	+	Splice_Site	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:143039237T>C	uc003wcr.1	+	15	1883	c.1796_splice	c.e15+2	p.S599_splice	CLCN1_uc011ktc.1_Splice_Site_p.S211_splice	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle						muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CCAGCTCAGGTCAGGGGCACT	0.512			NA											8	27					0	0	0.004482	0	0
OR2A2	442361	broad.mit.edu	37	7	143806842	143806842	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:143806842C>A	uc011ktz.1	+	1	167	c.167C>A	c.(166-168)ACA>AAA	p.T56K		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	56	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					AAGCTTCACACACCCATGTAC	0.473			NA											6	245					0.00198382	0.00223928	0.001984	1	0
OR2A7	401427	broad.mit.edu	37	7	143955988	143955988	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:143955988C>A	uc011kuc.1	-	1	734	c.734G>T	c.(733-735)TGT>TTT	p.C245F	OR2A9P_uc003wec.1_Intron|uc003wed.2_5'Flank	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					TCCAATCACACAGAGGTGGGA	0.453			NA											15	340					7.93312e-07	1.08814e-06	0.00245	1	0
NOBOX	135935	broad.mit.edu	37	7	144097292	144097292	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:144097292C>A	uc011kue.1	-	5	958	c.958G>T	c.(958-960)GGG>TGG	p.G320W		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	320	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GAGCCGGCCCCCTTTACCATG	0.587			NA											10	77					6.40141e-05	7.85819e-05	0.000978	1	0
NOS3	4846	broad.mit.edu	37	7	150704248	150704248	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:150704248G>T	uc003wif.2	+	17	2292	c.1996G>T	c.(1996-1998)GCC>TCC	p.A666S	NOS3_uc011kuy.1_Missense_Mutation_p.A460S	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	666	Flavodoxin-like.|FMN (By similarity).				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CTTTGCTCGTGCCGTGGACAC	0.697			NA											22	98					3.08376e-08	4.42453e-08	0.00333	1	0
PRSS55	203074	broad.mit.edu	37	8	10383137	10383137	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:10383137G>T	uc003wta.2	+	1	57	c.42G>T	c.(40-42)ACG>ACT	p.T14T	uc010lru.2_Intron	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	14					proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						CCCTGGTCACGGGAACTCAGC	0.677			NA											5	43					8.12818e-05	9.89135e-05	0.001984	1	0
RP1L1	94137	broad.mit.edu	37	8	10465503	10465503	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:10465503C>A	uc003wtc.2	-	4	6334	c.6105G>T	c.(6103-6105)CAG>CAT	p.Q2035H		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2035					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTTCAACCTCCTGGGCCTCTT	0.617			NA											15	160					0.00244969	0.0027596	0.00245	1	0
AMAC1L2	83650	broad.mit.edu	37	8	11189238	11189238	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:11189238T>A	uc003wtp.1	+	1	744	c.623T>A	c.(622-624)CTG>CAG	p.L208Q		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	208	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		CTGGGGCTTCTGGTCTATCGT	0.617			NA											11	83					0	0	0.008291	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20073974	20073974	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:20073974A>G	uc003wzp.2	+	11	1343	c.1129A>G	c.(1129-1131)ATC>GTC	p.I377V	ATP6V1B2_uc003wzq.1_5'Flank	NM_001693	NP_001684	P21281	VATB2_HUMAN	vacuolar H+ATPase B2	377					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		AGAGGGGCAGATCTATGTGGA	0.493	Pancreas(119;1230 1726 3901 4036 31644)		NA											4	35					0	0	0.000602	0	0
ADAM7	8756	broad.mit.edu	37	8	24326279	24326279	+	Splice_Site	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:24326279G>T	uc003xeb.2	+	7	693	c.580_splice	c.e7-1	p.G194_splice		NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TAACTTTACAGGGCATCCATG	0.308			NA											9	33					0.000442599	0.000519452	0.006214	1	0
MYST3	7994	broad.mit.edu	37	8	41792282	41792282	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:41792282C>T	uc010lxb.2	-	18	4000	c.3456G>A	c.(3454-3456)TGG>TGA	p.W1152*	MYST3_uc010lxc.2_Nonsense_Mutation_p.W1152*|MYST3_uc003xon.3_Nonsense_Mutation_p.W1152*	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1152					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TGCCTTTGGGCCATCCCTTTT	0.438			NA											31	437					0	0	0.002445	0	0
PLAT	5327	broad.mit.edu	37	8	42046462	42046462	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:42046462C>A	uc003xos.2	-	4	452	c.243G>T	c.(241-243)GTG>GTT	p.V81V	PLAT_uc010lxf.1_Intron|PLAT_uc010lxg.1_Silent_p.V81V|PLAT_uc003xot.2_Intron|PLAT_uc011lcm.1_Silent_p.V81V|PLAT_uc011lcn.1_Silent_p.V81V	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	81	Fibronectin type-I.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TTTTGACAGGCACTGAGTGGC	0.318			NA											115	232					3.79751e-50	6.76319e-50	0.00361	1	0
PREX2	80243	broad.mit.edu	37	8	68942818	68942818	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:68942818C>T	uc003xxv.1	+	6	657	c.630C>T	c.(628-630)AAC>AAT	p.N210N	PREX2_uc003xxu.1_Silent_p.N210N|PREX2_uc011lez.1_Silent_p.N145N	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	210	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TCTGTTCCAACATAAACGAGG	0.468			NA											32	73					0	0	0.003271	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618756	77618756	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:77618756G>T	uc003yav.2	+	2	2820	c.2433G>T	c.(2431-2433)TTG>TTT	p.L811F	ZFHX4_uc003yat.1_Missense_Mutation_p.L811F|ZFHX4_uc003yau.1_Missense_Mutation_p.L811F|ZFHX4_uc003yaw.1_Missense_Mutation_p.L811F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	811						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATCTGCACTTGGGCCTCGCCC	0.517			NA								HNSCC(33;0.089)			10	13					2.17888e-05	2.79075e-05	0.006214	1	0
SLC7A13	157724	broad.mit.edu	37	8	87242447	87242447	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:87242447A>T	uc003ydq.1	-	1	158	c.60T>A	c.(58-60)AGT>AGA	p.S20R	SLC7A13_uc003ydr.1_Missense_Mutation_p.S20R	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	20	Helical; Name=1; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						TAAGCAAAAAACTTGTGCCCC	0.388			NA											9	131					0	0	0.008291	0	0
MMP16	4325	broad.mit.edu	37	8	89086833	89086833	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:89086833C>G	uc003yeb.3	-	7	1504	c.1222G>C	c.(1222-1224)GGT>CGT	p.G408R	MMP16_uc003yec.2_Missense_Mutation_p.V408L	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	408	Hemopexin-like 2.|Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						ACATCCTTACCTTTAAAGAAC	0.388			NA											6	73					0	0	0.001984	0	0
SLC26A7	115111	broad.mit.edu	37	8	92307866	92307866	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:92307866T>C	uc003yex.2	+	5	690	c.412T>C	c.(412-414)TCC>CCC	p.S138P	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.S138P|SLC26A7_uc003yfa.2_Missense_Mutation_p.S138P	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	138	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GCTGGGCTTATCCGACTTTGA	0.483			NA											9	85					0	0	0.008291	0	0
RAD54B	25788	broad.mit.edu	37	8	95403926	95403926	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:95403926C>A	uc003ygk.2	-	10	1818	c.1720G>T	c.(1720-1722)GGG>TGG	p.G574W	RAD54B_uc010may.1_Missense_Mutation_p.G381W|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			TCCAACAACCCTTGAAGGCAG	0.398			NA						Direct_reversal_of_damage|Homologous_recombination					133	202					1.19401e-59	2.13324e-59	0.00361	1	0
INTS8	55656	broad.mit.edu	37	8	95877917	95877917	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:95877917C>T	uc003yhb.2	+	17	2386	c.2260C>T	c.(2260-2262)CGG>TGG	p.R754W	INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.R581W	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	754					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TATCATGTATCGGTATGTATT	0.333			NA											12	284					0	0	0.00245	0	0
SLC25A32	81034	broad.mit.edu	37	8	104415420	104415420	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:104415420T>G	uc003yll.2	-	4	827	c.524A>C	c.(523-525)AAG>ACG	p.K175T	SLC25A32_uc011lhr.1_Missense_Mutation_p.K43T	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	175	Solcar 2.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	ACCTTCATACTTATATATTTT	0.323			NA											21	36					0	0	0.010504	0	0
CSMD3	114788	broad.mit.edu	37	8	113326767	113326767	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:113326767A>T	uc003ynu.2	-	48	7599	c.7440T>A	c.(7438-7440)AAT>AAA	p.N2480K	CSMD3_uc003yns.2_Missense_Mutation_p.N1682K|CSMD3_uc003ynt.2_Missense_Mutation_p.N2440K|CSMD3_uc011lhx.1_Missense_Mutation_p.N2376K|CSMD3_uc003ynw.1_Missense_Mutation_p.N191K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2480	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACATTTGAAGATTTGGGTAAC	0.393			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	121					0	0	0.000602	0	0
CSMD3	114788	broad.mit.edu	37	8	113668537	113668537	+	Silent	SNP	T	T	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:113668537T>C	uc003ynu.2	-	18	3009	c.2850A>G	c.(2848-2850)GAA>GAG	p.E950E	CSMD3_uc003yns.2_Silent_p.E222E|CSMD3_uc003ynt.2_Silent_p.E910E|CSMD3_uc011lhx.1_Silent_p.E846E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	950	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATCATGAACTTCCAGAACAT	0.343			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	77					0	0	0.000602	0	0
TRPS1	7227	broad.mit.edu	37	8	116426404	116426404	+	Silent	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:116426404A>G	uc003ynz.2	-	6	4152	c.3693T>C	c.(3691-3693)GCT>GCC	p.A1231A	TRPS1_uc011lhy.1_Silent_p.A1235A|TRPS1_uc003yny.2_Silent_p.A1244A|TRPS1_uc010mcy.2_Silent_p.A1231A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1231	Transcriptional repressor domain (By similarity).|C2H2-type 6.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TCATATGCAAAGCATACATCA	0.413			NA							Langer-Giedion_syndrome				21	130					0	0	0.002299	0	0
CD274	29126	broad.mit.edu	37	9	5466808	5466808	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:5466808A>T	uc003zje.2	+	6	881	c.829A>T	c.(829-831)ACA>TCA	p.T277S	C9orf46_uc003zjd.2_Intron|CD274_uc010mhn.2_RNA|CD274_uc003zjf.2_Missense_Mutation_p.T163S	NM_014143	NP_054862	Q9NZQ7	PD1L1_HUMAN	CD274 molecule precursor	277	Cytoplasmic (Potential).				cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity			lung(1)|central_nervous_system(1)	2	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		CATCCAAGATACAAACTCAAA	0.348			NA	T	CIITA	PMBL|Hodgkin Lymphona|								10	73					0	0	0.000978	0	0
KIAA2026	158358	broad.mit.edu	37	9	5920563	5920563	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:5920563C>A	uc003zjq.3	-	8	5649	c.5433G>T	c.(5431-5433)TCG>TCT	p.S1811S	KIAA2026_uc010mht.2_Silent_p.S986S	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1811										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTGAAAGGGACGACAATTCAG	0.398			NA											41	527					5.44703e-19	9.14905e-19	0.009718	1	0
PTPRD	5789	broad.mit.edu	37	9	8340448	8340448	+	Silent	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:8340448A>T	uc003zkk.2	-	41	5859	c.5148T>A	c.(5146-5148)GCT>GCA	p.A1716A	PTPRD_uc003zkp.2_Silent_p.A1310A|PTPRD_uc003zkq.2_Silent_p.A1309A|PTPRD_uc003zkr.2_Silent_p.A1300A|PTPRD_uc003zks.2_Silent_p.A1309A|PTPRD_uc003zkl.2_Silent_p.A1707A|PTPRD_uc003zkm.2_Silent_p.A1703A|PTPRD_uc003zkn.2_Silent_p.A1305A|PTPRD_uc003zko.2_Silent_p.A1306A	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1716	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCCCCTGGGTAGCGATGTAGG	0.448			NA								TSP Lung(15;0.13)			4	72					0	0	0.009096	0	0
MPDZ	8777	broad.mit.edu	37	9	13119528	13119528	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:13119528G>A	uc010mia.1	-	38	5409	c.5352C>T	c.(5350-5352)ACC>ACT	p.T1784T	MPDZ_uc003zkx.3_Silent_p.T49T|MPDZ_uc003zky.3_Silent_p.T318T|MPDZ_uc010mib.2_Silent_p.T489T|MPDZ_uc010mhx.2_Silent_p.T606T|MPDZ_uc011lmm.1_Silent_p.T643T|MPDZ_uc003zkz.3_Silent_p.T477T|MPDZ_uc010mhy.2_Silent_p.T1784T|MPDZ_uc010mhz.2_Silent_p.T1751T|MPDZ_uc011lmn.1_Silent_p.T1751T|MPDZ_uc003zlb.3_Silent_p.T1784T	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1784	PDZ 11.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CCGCTTCTTGGGTGGCATTAC	0.398			NA											11	127					0	0	0.000978	0	0
MPDZ	8777	broad.mit.edu	37	9	13125264	13125264	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:13125264C>T	uc010mia.1	-	34	4815	c.4758G>A	c.(4756-4758)CAG>CAA	p.Q1586Q	MPDZ_uc003zky.3_Silent_p.Q148Q|MPDZ_uc010mib.2_Silent_p.Q291Q|MPDZ_uc010mhx.2_Silent_p.Q408Q|MPDZ_uc011lmm.1_Silent_p.Q445Q|MPDZ_uc003zkz.3_Silent_p.Q279Q|MPDZ_uc010mhy.2_Silent_p.Q1586Q|MPDZ_uc010mhz.2_Silent_p.Q1553Q|MPDZ_uc011lmn.1_Silent_p.Q1553Q|MPDZ_uc003zlb.3_Silent_p.Q1586Q	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1586					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CCATCAGAGACTGGGAGCTGT	0.517			NA											7	81					0	0	0.00308	0	0
SH3GL2	6456	broad.mit.edu	37	9	17795682	17795682	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:17795682G>T	uc003zna.2	+	9	1288	c.1000G>T	c.(1000-1002)GGC>TGC	p.G334C	SH3GL2_uc011lmy.1_Missense_Mutation_p.G287C	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	334	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GATGCTGCATGGCCATTCAGG	0.478			NA											6	38					1.06961e-07	1.50767e-07	0.00308	1	0
ANXA1	301	broad.mit.edu	37	9	75778406	75778406	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:75778406G>A	uc004ajf.1	+	8	644	c.570G>A	c.(568-570)GAG>GAA	p.E190E	ANXA1_uc004aje.1_Silent_p.E190E|ANXA1_uc004ajg.1_Silent_p.E190E	NM_000700	NP_000691	P04083	ANXA1_HUMAN	annexin I	190					alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)	2		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)	ACCGATCTGAGGACTTTGGTG	0.388			NA											16	64					0	0	0.00499	0	0
PCSK5	5125	broad.mit.edu	37	9	78789943	78789943	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:78789943G>T	uc004ajz.2	+	14	2336	c.1798G>T	c.(1798-1800)GTG>TTG	p.V600L	PCSK5_uc004ajy.2_Missense_Mutation_p.V600L|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	600	Homo B/P.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CGGCACCTCCGTGCAGCCATA	0.443			NA											9	73					0.000978159	0.00112448	0.000978	1	0
FLJ46321	389763	broad.mit.edu	37	9	84604696	84604696	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:84604696C>G	uc004amn.2	+	2	237	c.190C>G	c.(190-192)CAG>GAG	p.Q64E		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	64						integral to membrane					0						TTCTCAGCATCAGGGCAGAGC	0.398			NA											7	41					0	0	0.00308	0	0
DAPK1	1612	broad.mit.edu	37	9	90312088	90312088	+	Silent	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:90312088G>T	uc004apc.2	+	22	2718	c.2580G>T	c.(2578-2580)CTG>CTT	p.L860L	DAPK1_uc004apd.2_Silent_p.L860L|DAPK1_uc011ltg.1_Intron|DAPK1_uc011lth.1_Silent_p.L597L	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	860					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						TCAGTTTCCTGAAGTCCCTTG	0.502			NA							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				9	56					1.12685e-05	1.47015e-05	0.004482	1	0
ROR2	4920	broad.mit.edu	37	9	94486199	94486199	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:94486199G>A	uc004arj.1	-	9	2776	c.2577C>T	c.(2575-2577)CCC>CCT	p.P859P	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	859	Cytoplasmic (Potential).|Ser/Thr-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GGTGTGAGCTGGGCTTGGGGA	0.652			NA											9	68					0	0	0.006214	0	0
COL15A1	1306	broad.mit.edu	37	9	101747956	101747956	+	Silent	SNP	G	G	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:101747956G>A	uc004azb.1	+	3	416	c.210G>A	c.(208-210)GGG>GGA	p.G70G	COL15A1_uc004aza.2_Silent_p.G70G	NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	70	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				ACAGTTTCGGGCCTGGTGCCA	0.632			NA											9	30					0	0	0.008291	0	0
OR13F1	138805	broad.mit.edu	37	9	107267232	107267232	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:107267232C>A	uc011lvm.1	+	1	689	c.689C>A	c.(688-690)TCA>TAA	p.S230*		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						AGAATCAGCTCAGTGGAAGGT	0.478			NA											38	144					4.92203e-23	8.54878e-23	0.00623	1	0
ACTL7B	10880	broad.mit.edu	37	9	111617373	111617373	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:111617373C>A	uc004bdi.2	-	1	903	c.838G>T	c.(838-840)GAC>TAC	p.D280Y		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	280						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						AGCTCGTAGTCCACGCGCAGC	0.627			NA											14	52					3.27435e-08	4.67408e-08	0.00245	1	0
SUSD1	64420	broad.mit.edu	37	9	114904686	114904686	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:114904686C>G	uc004bfu.2	-	5	661	c.620G>C	c.(619-621)AGA>ACA	p.R207T	SUSD1_uc010mui.2_Missense_Mutation_p.R207T|SUSD1_uc010muj.2_Missense_Mutation_p.R207T	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	207	Sushi 1.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						GAATCCTTCTCTGCAAGCATA	0.453			NA											15	204					0	0	0.00245	0	0
OR1L8	138881	broad.mit.edu	37	9	125329898	125329898	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:125329898G>T	uc004bmp.1	-	1	859	c.859C>A	c.(859-861)CCT>ACT	p.P287T		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						TAGATAAAAGGATTGAGCATG	0.458			NA											15	123					4.7546e-09	6.94618e-09	0.004007	1	0
LAMC3	10319	broad.mit.edu	37	9	133932433	133932433	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:133932433C>G	uc004caa.1	+	12	2155	c.2057C>G	c.(2056-2058)TCC>TGC	p.S686C		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	686	Laminin EGF-like 5; second part.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TTCTGTGAATCCTGTGCTCCG	0.622			NA											13	100					0	0	0.00245	0	0
TSC1	7248	broad.mit.edu	37	9	135781380	135781381	+	Missense_Mutation	DNP	CG	CG	AA	rs149439187		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr9:135781380_135781381CG>AA	uc004cca.2	-	15	1818_1819	c.1584_1585CG>TT	c.(1582-1587)GGCGCC>GGTTCC	p.A529S	TSC1_uc004ccb.3_Missense_Mutation_p.A528S|TSC1_uc011mcq.1_Missense_Mutation_p.A478S|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	529					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TTCACGCTGGCGCCCTGAGAAC	0.594			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				5	28					0	0	0.004672	0	0
MSL3	10943	broad.mit.edu	37	X	11790301	11790301	+	Silent	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:11790301C>T	uc004cuw.2	+	11	1413	c.1308C>T	c.(1306-1308)GAC>GAT	p.D436D	MSL3_uc004cux.2_Silent_p.D377D|MSL3_uc011mig.1_Silent_p.D287D|MSL3_uc011mih.1_Silent_p.D424D|MSL3_uc004cuy.2_Silent_p.D270D	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	436					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTGTGCCTGACAATTACCCCC	0.463			NA											8	178					0	0	0.006214	0	0
DMD	1756	broad.mit.edu	37	X	32380907	32380907	+	Nonsense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:32380907T>A	uc004dda.1	-	37	5567	c.5323A>T	c.(5323-5325)AAG>TAG	p.K1775*	DMD_uc004dcw.2_Nonsense_Mutation_p.K431*|DMD_uc004dcx.2_Nonsense_Mutation_p.K434*|DMD_uc004dcz.2_Nonsense_Mutation_p.K1652*|DMD_uc004dcy.1_Nonsense_Mutation_p.K1771*|DMD_uc004ddb.1_Nonsense_Mutation_p.K1767*|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1775	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTTCCTACCTTTCCAGTCTTA	0.488			NA											12	80					0	0	0.000978	0	0
RPGR	6103	broad.mit.edu	37	X	38144877	38144877	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:38144877C>A	uc004ded.1	-	15	3543	c.3375G>T	c.(3373-3375)CAG>CAT	p.Q1125H	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GTCGTTTTGACTGGACTGGCA	0.358			NA											34	231					5.43694e-19	9.14905e-19	0.005524	1	0
OTUD5	55593	broad.mit.edu	37	X	48781242	48781242	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:48781242G>C	uc004dlu.2	-	7	1427	c.1366C>G	c.(1366-1368)CGG>GGG	p.R456G	OTUD5_uc004dlt.3_Missense_Mutation_p.R451G|OTUD5_uc004dlv.2_Missense_Mutation_p.R451G|OTUD5_uc011mmp.1_Missense_Mutation_p.R234G	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	456					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						GCTGAACTCCGCTGCCGCGGG	0.637			NA											4	14					0	0	0.009096	0	0
PAGE2	203569	broad.mit.edu	37	X	55116444	55116444	+	Splice_Site	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:55116444A>T	uc004duf.1	+	2	47	c.-7_splice	c.e2-2			NM_207339	NP_997222	Q7Z2X7	GGEE2_HUMAN	P antigen family, member 2											ovary(2)	2						TTCTGTTTGCAGTGGGAAATA	0.368			NA											3	46					0	0	0.004672	0	0
OGT	8473	broad.mit.edu	37	X	70783033	70783033	+	Silent	SNP	A	A	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:70783033A>T	uc004eaa.1	+	17	2419	c.2202A>T	c.(2200-2202)ATA>ATT	p.I734I	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.I724I|OGT_uc004eac.2_Silent_p.I595I|OGT_uc004ead.2_Silent_p.I353I	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	734					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					ACAATCGGATAGTTCTGAATG	0.343			NA											5	153					0	0	0.000602	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177403	89177403	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:89177403C>G	uc004efe.2	+	2	368	c.319C>G	c.(319-321)CGC>GGC	p.R107G		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	107	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TGCTCGCAGACGCATTCTCCC	0.493			NA											16	150					0	0	0.010504	0	0
COL4A5	1287	broad.mit.edu	37	X	107807111	107807111	+	Splice_Site	SNP	G	G	T	rs104886350		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:107807111G>T	uc004enz.1	+	4	434	c.232_splice	c.e4-1	p.G78_splice	COL4A5_uc011mso.1_Splice_Site_p.G78_splice	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor						axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GCATTTTTCAGGGTGATGATG	0.333			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				14	45					0.000422831	0.000498337	0.004007	1	0
COL4A5	1287	broad.mit.edu	37	X	107898561	107898561	+	Missense_Mutation	SNP	G	G	T	rs104886223		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:107898561G>T	uc004enz.1	+	37	3449	c.3247G>T	c.(3247-3249)GGT>TGT	p.G1083C	COL4A5_uc011mso.1_Missense_Mutation_p.G1083C	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1083	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GTGTTTTCAGGGTGAGCCTGG	0.388			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				18	54					4.96729e-08	7.07271e-08	0.008871	1	0
IRS4	8471	broad.mit.edu	37	X	107977781	107977781	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:107977781T>A	uc004eoc.2	-	1	1827	c.1794A>T	c.(1792-1794)AAA>AAT	p.K598N		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	598						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CATCGGATCCTTTCCCACTTC	0.537			NA											77	174					0	0	0.00361	0	0
TMEM164	84187	broad.mit.edu	37	X	109388104	109388104	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:109388104G>T	uc004eom.2	+	5	905	c.586G>T	c.(586-588)GGT>TGT	p.G196C	TMEM164_uc004eol.2_Missense_Mutation_p.G47C|TMEM164_uc010npq.2_Missense_Mutation_p.G157C	NM_032227	NP_115603	Q5U3C3	TM164_HUMAN	transmembrane protein 164 isoform b	196						integral to membrane				large_intestine(1)|lung(1)|skin(1)	3						TTGGAAAGGAGGTAAGGCCAG	0.493			NA											5	95					3.59834e-05	4.51603e-05	0.001168	1	0
KIAA1210	57481	broad.mit.edu	37	X	118223471	118223471	+	Silent	SNP	A	A	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:118223471A>C	uc004era.3	-	11	1722	c.1722T>G	c.(1720-1722)CCT>CCG	p.P574P		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	574										ovary(4)|skin(1)	5						TCTTATTGGTAGGTGAAGACC	0.488			NA											42	90					0	0	0.00874	0	0
KIAA1210	57481	broad.mit.edu	37	X	118284525	118284525	+	Silent	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:118284525C>A	uc004era.3	-	1	18	c.18G>T	c.(16-18)ACG>ACT	p.T6T		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	6										ovary(4)|skin(1)	5						AGCCTCGAGGCGTCCAGCCGG	0.652			NA											8	70					2.17888e-05	2.79075e-05	0.006214	1	0
ODZ1	10178	broad.mit.edu	37	X	123519722	123519722	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:123519722C>A	uc004euj.2	-	28	5924	c.5860G>T	c.(5860-5862)GGC>TGC	p.G1954C	ODZ1_uc011muj.1_Missense_Mutation_p.G1960C|ODZ1_uc010nqy.2_Missense_Mutation_p.G1961C	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1954	YD 11.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AGCAATCGGCCATCTCGACTA	0.498			NA											8	159					0.000274275	0.000324617	0.004482	1	0
HTATSF1	27336	broad.mit.edu	37	X	135593508	135593508	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:135593508C>T	uc004ezw.2	+	10	2026	c.1604C>T	c.(1603-1605)CCC>CTC	p.P535L	HTATSF1_uc004ezx.2_Missense_Mutation_p.P535L	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	535	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GAGGTTGGCCCCACAAAAGAG	0.418			NA											22	50					0	0	0.010504	0	0
MAGEC3	139081	broad.mit.edu	37	X	140985169	140985169	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:140985169G>C	uc011mwp.1	+	7	1625	c.1625G>C	c.(1624-1626)GGC>GCC	p.G542A	MAGEC3_uc004fbs.2_Missense_Mutation_p.G244A|MAGEC3_uc010nsj.2_Missense_Mutation_p.G244A	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	542	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GATGACCAGGGCATGCCCAAG	0.478			NA											15	167					0	0	0.004007	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995914	140995915	+	Missense_Mutation	DNP	GG	GG	TA			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:140995914_140995915GG>TA	uc004fbt.2	+	4	3010_3011	c.2724_2725GG>TA	c.(2722-2727)CTGGAT>CTTAAT	p.D909N	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	909	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTTATACACTGGATGAAAAGGT	0.46			NA								HNSCC(15;0.026)			33	341					0	0	0.004672	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718545	142718545	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:142718545A>G	uc004fbx.2	-	2	756	c.380T>C	c.(379-381)TTC>TCC	p.F127S	SLITRK4_uc004fby.2_Missense_Mutation_p.F127S	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	127	Extracellular (Potential).|LRR 3.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TATGCCAAGGAAAGTGTCAGC	0.418			NA											11	184					0	0	0.008291	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904874	144904874	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:144904874C>G	uc004fcd.2	+	5	1921	c.931C>G	c.(931-933)CCA>GCA	p.P311A	SLITRK2_uc010nsp.2_Missense_Mutation_p.P311A|SLITRK2_uc010nso.2_Missense_Mutation_p.P311A|SLITRK2_uc011mwq.1_Missense_Mutation_p.P311A|SLITRK2_uc011mwr.1_Missense_Mutation_p.P311A|SLITRK2_uc011mws.1_Missense_Mutation_p.P311A|SLITRK2_uc004fcg.2_Missense_Mutation_p.P311A|SLITRK2_uc011mwt.1_Missense_Mutation_p.P311A	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	311	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GAGAAATCGTCCAACTCCTCG	0.552			NA											5	78					0	0	0.000602	0	0
AFF2	2334	broad.mit.edu	37	X	147743813	147743813	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:147743813T>G	uc004fcp.2	+	3	1044	c.565T>G	c.(565-567)TCT>GCT	p.S189A	AFF2_uc004fco.2_Missense_Mutation_p.S185A|AFF2_uc004fcq.2_Missense_Mutation_p.S185A|AFF2_uc004fcr.2_Missense_Mutation_p.S185A|AFF2_uc011mxb.1_Missense_Mutation_p.S189A|AFF2_uc004fcs.2_Missense_Mutation_p.S185A	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	189					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGGACCAGTCTCAAGCCAA	0.493			NA											14	223					0	0	0.001855	0	0
AFF2	2334	broad.mit.edu	37	X	148037217	148037217	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:148037217C>A	uc004fcp.2	+	11	2121	c.1642C>A	c.(1642-1644)CAA>AAA	p.Q548K	AFF2_uc004fcq.2_Missense_Mutation_p.Q538K|AFF2_uc004fcr.2_Missense_Mutation_p.Q509K|AFF2_uc011mxb.1_Missense_Mutation_p.Q513K|AFF2_uc004fcs.2_Missense_Mutation_p.Q515K|AFF2_uc011mxc.1_Missense_Mutation_p.Q189K	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	548				Q -> P (in Ref. 1; AAC82513, 2; AAA99416 and 4; AAB71534).	brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TATTTGTGGCCAAAATGAAAC	0.463			NA											33	401					2.09667e-21	3.63034e-21	0.003755	1	0
MAGEA10	4109	broad.mit.edu	37	X	151303295	151303295	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:151303295C>A	uc004ffk.2	-	5	1206	c.798G>T	c.(796-798)GAG>GAT	p.E266D	MAGEA10_uc004ffl.2_Missense_Mutation_p.E266D	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	266	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GCTTCCTGGGCTCCCCATAAA	0.547			NA											12	114					0.00010058	0.000121606	0.001368	1	0
Unknown	0	broad.mit.edu	37	X	153626712	153626712	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrX:153626712G>T	uc010nuv.1	-	1	467	c.151C>A	c.(151-153)CCT>ACT	p.P51T	RPL10_uc004fkm.2_5'UTR|RPL10_uc004fko.2_5'UTR|RPL10_uc004fkn.1_5'Flank|RPL10_uc004fkp.1_5'Flank|RPL10_uc004fkq.1_5'Flank|RPL10_uc004fkr.1_5'Flank|SNORA70_uc010nux.1_5'Flank					Homo sapiens cDNA, FLJ97181.												NA						GCAGGCGGAGGAGCGCCTCTT	0.567			NA									OREG0003599	type=REGULATORY REGION|Gene=RPL10|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	81					0.00198382	0.00223928	0.001984	1	0
NLGN4Y	22829	broad.mit.edu	37	Y	16952497	16952497	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chrY:16952497G>T	uc004ftg.2	+	6	2058	c.1806G>T	c.(1804-1806)GAG>GAT	p.E602D	NLGN4Y_uc004fte.2_Missense_Mutation_p.E434D|NLGN4Y_uc011nas.1_Missense_Mutation_p.E622D|NLGN4Y_uc004ftf.2_Missense_Mutation_p.E295D|NLGN4Y_uc004fth.2_Missense_Mutation_p.E602D	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	602	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						ACTTGAACGAGATATTCCAGT	0.478			NA											7	37					5.18039e-06	6.90309e-06	0.00308	1	0
SYCP1	6847	broad.mit.edu	37	1	115527385	115527386	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:115527385_115527386insA	uc001efr.2	+	30	2808_2809	c.2599_2600insA	c.(2599-2601)CAAfs	p.Q867fs	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Frame_Shift_Ins_p.Q867fs|SYCP1_uc009wgw.2_Frame_Shift_Ins_p.Q842fs	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	867					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAACTACAGCAAAGAGAAAAC	0.267			NA											9	153	---	---	---	---	NA	NA	NA	NA	NA
FLG	2312	broad.mit.edu	37	1	152280635	152280635	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:152280635delC	uc001ezu.1	-	3	6763	c.6727delG	c.(6727-6729)GTTfs	p.V2243fs		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2243	Ser-rich.|Filaggrin 13.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGGCTAACACTGGATCCC	0.572			NA							Ichthyosis				22	357	---	---	---	---	NA	NA	NA	NA	NA
FMO1	2326	broad.mit.edu	37	1	171250038	171250038	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:171250038delC	uc009wvz.2	+	6	877	c.741delC	c.(739-741)CTCfs	p.L247fs	FMO1_uc010pme.1_Frame_Shift_Del_p.L184fs|FMO1_uc001ghl.2_Frame_Shift_Del_p.L247fs|FMO1_uc001ghm.2_Frame_Shift_Del_p.L247fs|FMO1_uc001ghn.2_Frame_Shift_Del_p.L247fs	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	247					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAAATTCCCTCCCAACCCCAA	0.468			NA											16	126	---	---	---	---	NA	NA	NA	NA	NA
SMG7	9887	broad.mit.edu	37	1	183511555	183511557	+	In_Frame_Del	DEL	ACA	ACA	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	ACA	ACA	-	-	ACA	ACA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr1:183511555_183511557delACA	uc001gqg.2	+	14	1882_1884	c.1760_1762delACA	c.(1759-1764)GACAAC>GAC	p.N589del	SMG7_uc010pob.1_Intron|SMG7_uc001gqf.2_Intron|SMG7_uc001gqh.2_Intron|SMG7_uc001gqi.2_Intron|SMG7_uc010poc.1_In_Frame_Del_p.N547del	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	589					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GGAAAGAAGGACAACAACAAGAG	0.404			NA											19	90	---	---	---	---	NA	NA	NA	NA	NA
NELL1	4745	broad.mit.edu	37	11	21594744	21594745	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr11:21594744_21594745insT	uc001mqe.2	+	19	2324_2325	c.2171_2172insT	c.(2170-2172)GATfs	p.D724fs	NELL1_uc001mqf.2_Frame_Shift_Ins_p.D677fs|NELL1_uc009yid.2_Frame_Shift_Ins_p.D752fs|NELL1_uc010rdo.1_Frame_Shift_Ins_p.D667fs|NELL1_uc010rdp.1_Frame_Shift_Ins_p.D437fs|NELL1_uc001mqh.2_Frame_Shift_Ins_p.D269fs	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	724	VWFC 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GGAGAGGTAGATTGCTGGCCAC	0.45			NA											13	68	---	---	---	---	NA	NA	NA	NA	NA
FGD4	121512	broad.mit.edu	37	12	32735271	32735271	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:32735271delG	uc001rkz.2	+	4	947	c.470delG	c.(469-471)AGGfs	p.R157fs	FGD4_uc001rlc.2_Frame_Shift_Del_p.R242fs|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Frame_Shift_Del_p.R269fs|FGD4_uc001rlb.1_RNA|FGD4_uc001rkx.3_Frame_Shift_Del_p.R157fs	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	157					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					AGTAGCTACAGGACTCCAGGC	0.507			NA											49	92	---	---	---	---	NA	NA	NA	NA	NA
MAP3K12	7786	broad.mit.edu	37	12	53877180	53877180	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:53877180delA	uc001sdm.1	-	11	1565	c.1467delT	c.(1465-1467)CTTfs	p.L489fs	MAP3K12_uc001sdn.1_Frame_Shift_Del_p.L522fs	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	489					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						TCTTCTTGATAAGCTTCTCCA	0.532			NA											23	153	---	---	---	---	NA	NA	NA	NA	NA
MON2	23041	broad.mit.edu	37	12	62954583	62954583	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr12:62954583delG	uc001sre.2	+	26	4113	c.3722delG	c.(3721-3723)TGGfs	p.W1241fs	MON2_uc009zqj.2_Frame_Shift_Del_p.W1241fs|MON2_uc010ssl.1_Frame_Shift_Del_p.W1169fs|MON2_uc010ssm.1_Frame_Shift_Del_p.W1218fs|MON2_uc010ssn.1_Frame_Shift_Del_p.W1241fs|MON2_uc001srf.2_Frame_Shift_Del_p.W1004fs|MON2_uc001srg.2_Frame_Shift_Del_p.W116fs	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1242					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		AATCTATGGTGGGCTGCGTGG	0.383			NA											14	94	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579471	7579471	+	Frame_Shift_Del	DEL	G	G	-	rs56275308		TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:7579471delG	uc002gim.2	-	4	410	c.216delC	c.(214-216)CCCfs	p.P72fs	TP53_uc002gig.1_Frame_Shift_Del_p.P72fs|TP53_uc002gih.2_Frame_Shift_Del_p.P72fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P72fs|TP53_uc010cni.1_Frame_Shift_Del_p.P72fs|TP53_uc002gij.2_Frame_Shift_Del_p.P72fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P33fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P87fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	72	Interaction with WWOX.|Interaction with HRMT1L2.		P -> C (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> L (in a sporadic cancer; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> G (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.R72fs*51(6)|p.G59fs*23(3)|p.R72C(2)|p.V73fs*76(2)|p.R72H(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.V73fs*50(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGCCACGGGGGGAGCAG	0.602	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	138	---	---	---	---	NA	NA	NA	NA	NA
DDX5	1655	broad.mit.edu	37	17	62499955	62499958	+	Frame_Shift_Del	DEL	TGAT	TGAT	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	TGAT	TGAT	-	-	TGAT	TGAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr17:62499955_62499958delTGAT	uc002jek.2	-	5	717_720	c.470_473delATCA	c.(469-474)AATCATfs	p.N157fs	DDX5_uc010deh.2_Frame_Shift_Del_p.N157fs|DDX5_uc002jej.2_Frame_Shift_Del_p.N52fs|DDX5_uc010wqa.1_Intron|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	157_158	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			GAATGGCTGATGATTGATGTGGAC	0.328	NSCLC(22;406 813 4871 19580 40307)		NA	T	ETV4	prostate								16	118	---	---	---	---	NA	NA	NA	NA	NA
REG3A	5068	broad.mit.edu	37	2	79385513	79385513	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:79385513delA	uc002sod.1	-	3	527	c.272delT	c.(271-273)CTGfs	p.L91fs	REG3A_uc002soe.1_Frame_Shift_Del_p.L91fs|REG3A_uc002sof.1_Frame_Shift_Del_p.L91fs	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	91	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GCTCTTCACCAGGGAGGACAC	0.552			NA											11	58	---	---	---	---	NA	NA	NA	NA	NA
FAM168B	130074	broad.mit.edu	37	2	131813266	131813266	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:131813266delA	uc002tsd.2	-	4	386	c.157delT	c.(157-159)TACfs	p.Y53fs		NM_001009993	NP_001009993	A1KXE4	F168B_HUMAN	hypothetical protein LOC130074	53											0						CCAGGAGTGTAACCTGGAACA	0.622			NA											10	28	---	---	---	---	NA	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	140997093	140997094	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:140997093_140997094insA	uc002tvj.1	-	88	14304_14305	c.13332_13333insT	c.(13330-13335)ATTGCCfs	p.I4444fs		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4444_4445	Helical; (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAATGATGGCAATGCTTCCTG	0.287	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			13	46	---	---	---	---	NA	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	141806572	141806573	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:141806572_141806573delTC	uc002tvj.1	-	11	2743_2744	c.1771_1772delGA	c.(1771-1773)GAAfs	p.E591fs	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	591	Extracellular (Potential).|LDL-receptor class B 5.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGGATGGTTTCTCTCTCTGTG	0.436	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			14	151	---	---	---	---	NA	NA	NA	NA	NA
ZEB2	9839	broad.mit.edu	37	2	145156965	145156966	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:145156965_145156966insA	uc002tvu.2	-	8	2268_2269	c.1788_1789insT	c.(1786-1791)TTGCATfs	p.L596fs	ZEB2_uc002tvv.2_Frame_Shift_Ins_p.L590fs|ZEB2_uc010zbm.1_Frame_Shift_Ins_p.L567fs|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Frame_Shift_Ins_p.L625fs	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	596_597						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCATGCTGATGCAAAGGGATGG	0.426	Melanoma(33;1235 1264 5755 16332)		NA											7	158	---	---	---	---	NA	NA	NA	NA	NA
GALNT13	114805	broad.mit.edu	37	2	154801049	154801049	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:154801049delT	uc002tyr.3	+	3	606	c.39delT	c.(37-39)ACTfs	p.T13fs	GALNT13_uc002tyt.3_Frame_Shift_Del_p.T13fs	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	13	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TTCTAGCCACTTCGCTGATGT	0.408			NA											26	263	---	---	---	---	NA	NA	NA	NA	NA
CPS1	1373	broad.mit.edu	37	2	211466964	211466964	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr2:211466964delC	uc002vee.3	+	16	1878	c.1746delC	c.(1744-1746)TACfs	p.Y582fs	CPS1_uc010fur.2_Frame_Shift_Del_p.Y588fs|CPS1_uc010fus.2_Frame_Shift_Del_p.Y131fs	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	582	ATP-grasp 1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCATTGGCTACCCAGTGATGA	0.488			NA											9	77	---	---	---	---	NA	NA	NA	NA	NA
SETD2	29072	broad.mit.edu	37	3	47164413	47164414	+	Frame_Shift_Ins	INS	-	-	C			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr3:47164413_47164414insC	uc003cqs.2	-	3	1765_1766	c.1712_1713insG	c.(1711-1713)AATfs	p.N571fs	SETD2_uc003cqv.2_Frame_Shift_Ins_p.N560fs	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AACAGAAAGAATTTTTAAATTT	0.327			NA	N|F|S|Mis		clear cell renal carcinoma								21	153	---	---	---	---	NA	NA	NA	NA	NA
SGTB	54557	broad.mit.edu	37	5	65008852	65008852	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr5:65008852delG	uc003jud.2	-	3	360	c.140delC	c.(139-141)CCAfs	p.P47fs		NM_019072	NP_061945	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat	47	TPR 1.						binding				0		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		TGTATCTTCTGGGCTGATCTT	0.299			NA											22	153	---	---	---	---	NA	NA	NA	NA	NA
KDM1B	221656	broad.mit.edu	37	6	18222173	18222173	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr6:18222173delG	uc003nco.1	+	15	1885	c.1810delG	c.(1810-1812)GGGfs	p.G604fs	KDM1B_uc003ncn.1_Frame_Shift_Del_p.G575fs|KDM1B_uc003ncp.1_Frame_Shift_Del_p.G160fs|KDM1B_uc003ncq.1_Frame_Shift_Del_p.R158fs	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	807					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						AACTGTTACAGGGGCATATTT	0.393			NA											28	218	---	---	---	---	NA	NA	NA	NA	NA
HIP1	3092	broad.mit.edu	37	7	75228558	75228559	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:75228558_75228559insT	uc003uds.1	-	2	168_169	c.127_128insA	c.(127-129)AGCfs	p.S43fs		NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	43	ENTH.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CTTATTGATGCTGACAGTCTGA	0.505			NA	T	PDGFRB	CMML								7	141	---	---	---	---	NA	NA	NA	NA	NA
SAMD9	54809	broad.mit.edu	37	7	92731758	92731759	+	Frame_Shift_Ins	INS	-	-	G			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:92731758_92731759insG	uc003umf.2	-	3	3908_3909	c.3652_3653insC	c.(3652-3654)GATfs	p.D1218fs	SAMD9_uc003umg.2_Frame_Shift_Ins_p.D1218fs	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1218						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ATTTTTATTATCAAAAAAAGGA	0.337			NA											16	138	---	---	---	---	NA	NA	NA	NA	NA
NUB1	51667	broad.mit.edu	37	7	151064199	151064199	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr7:151064199delG	uc003wjx.2	+	9	1052	c.1047delG	c.(1045-1047)CTGfs	p.L349fs	NUB1_uc003wjw.2_Frame_Shift_Del_p.L325fs|NUB1_uc010lqc.2_RNA|uc003wjz.1_RNA	NM_016118	NP_057202	Q9Y5A7	NUB1_HUMAN	NEDD8 ultimate buster-1	325					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		ATCAGAGACTGGTCCACATAA	0.378			NA											7	74	---	---	---	---	NA	NA	NA	NA	NA
PKHD1L1	93035	broad.mit.edu	37	8	110445422	110445424	+	In_Frame_Del	DEL	GTT	GTT	-			TCGA-50-5941-01A-11D-1753-08	TCGA-50-5941-10A-01D-1753-08	GTT	GTT	-	-	GTT	GTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	86ef12c0-d5fc-4852-9960-593366e717b4	9054c3ce-7029-46bc-933e-18046c1bba73	g.chr8:110445422_110445424delGTT	uc003yne.2	+	28	3421_3423	c.3317_3319delGTT	c.(3316-3321)GGTTGT>GGT	p.C1107del		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1107	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGACCAGTAGGTTGTTCTCTTCT	0.369			NA								HNSCC(38;0.096)			22	417	---	---	---	---	NA	NA	NA	NA	NA
